lactic acid has been researched along with Brain Damage, Chronic in 27 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Brain Damage, Chronic: A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Endovascular treatment of intracranial aneurysms by using Matrix detachable coils is feasible and demonstrated initial angiographic results and overall morbidity and mortality rates that are within the ranges found in the literature in the use of bare platinum coils." | 5.12 | Endovascular treatment of intracranial aneurysms with matrix detachable coils: immediate posttreatment results from a prospective multicenter registry. ( Bonafé, A; Bracard, S; Leclerc, X; Pierot, L, 2006) |
| "When biochemical signs of cerebral ischemia progressed, i." | 1.37 | Prostacyclin infusion may prevent secondary damage in pericontusional brain tissue. ( Nordström, CH; Reinstrup, P, 2011) |
| "Transorbital 2 hour middle cerebral artery occlusion (MCAO) was performed in eight monkeys, which were studied with continuous microdialysis for 24 hours." | 1.31 | Increase of interstitial glycerol reflects the degree of ischaemic brain damage: a PET and microdialysis study in a middle cerebral artery occlusion-reperfusion primate model. ( Enblad, P; Frykholm, P; Hillered, L; Långström, B; Persson, L; Valtysson, J; Watanabe, Y, 2001) |
| "The majority of patients with PDHC deficiency have abnormalities in the major catalytic and regulatory subunit, E1 alpha, which is encoded on the X chromosome." | 1.29 | Cerebral dysgenesis and lactic acidemia: an MRI/MRS phenotype associated with pyruvate dehydrogenase deficiency. ( Arnold, DL; Brown, GK; Brown, RM; Legris, M; Matthews, PM; Otero, LJ; Scriver, CR; Shevell, MI, 1994) |
| "Neurologic outcome of hypoxic ischemic coma after cardiac arrest was studied in 32 patients." | 1.27 | Prediction of outcome after cardiac arrest. ( Edgren, E; Hedstrand, U; Nordin, M; Ronquist, G; Rydin, E, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (18.52) | 18.7374 |
| 1990's | 13 (48.15) | 18.2507 |
| 2000's | 7 (25.93) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Clausen, F | 1 |
| Hillered, L | 2 |
| Gustafsson, J | 1 |
| Reinstrup, P | 1 |
| Nordström, CH | 1 |
| Schurr, A | 1 |
| Chou, YT | 1 |
| Lai, ST | 1 |
| Lee, CC | 1 |
| Lin, MT | 1 |
| Abe, K | 1 |
| Pierot, L | 1 |
| Bonafé, A | 1 |
| Bracard, S | 1 |
| Leclerc, X | 1 |
| Hoberg, B | 1 |
| Delank, HW | 1 |
| Shevell, MI | 1 |
| Matthews, PM | 1 |
| Scriver, CR | 1 |
| Brown, RM | 1 |
| Otero, LJ | 1 |
| Legris, M | 1 |
| Brown, GK | 1 |
| Arnold, DL | 1 |
| Sahuquillo, J | 1 |
| Poca, MA | 1 |
| Garnacho, A | 1 |
| Robles, A | 1 |
| Coello, F | 1 |
| Godet, C | 1 |
| Triginer, C | 1 |
| Rubio, E | 1 |
| Marmarou, A | 1 |
| Holdaway, R | 1 |
| Ward, JD | 1 |
| Yoshida, K | 1 |
| Choi, SC | 1 |
| Muizelaar, JP | 1 |
| Young, HF | 1 |
| Behar, KL | 1 |
| Fitzpatrick, SM | 1 |
| Hetherington, HP | 1 |
| Shulman, RG | 1 |
| Staub, F | 1 |
| Winkler, A | 1 |
| Haberstok, J | 1 |
| Plesnila, N | 2 |
| Peters, J | 1 |
| Chang, RC | 1 |
| Kempski, O | 1 |
| Baethmann, A | 2 |
| Leth, H | 1 |
| Toft, PB | 1 |
| Peitersen, B | 1 |
| Lou, HC | 1 |
| Henriksen, O | 1 |
| Sibbitt, WL | 1 |
| Haseler, LJ | 1 |
| Griffey, RR | 1 |
| Friedman, SD | 1 |
| Brooks, WM | 1 |
| Sperl, W | 1 |
| Felber, S | 1 |
| Skladal, D | 1 |
| Wermuth, B | 1 |
| Sakamoto, K | 1 |
| Murata, T | 1 |
| Omori, M | 1 |
| Kimura, H | 1 |
| Nishio, M | 1 |
| Murata, I | 1 |
| Koshino, Y | 1 |
| Itoh, S | 1 |
| Ishii, Y | 1 |
| Isaki, K | 1 |
| Hanrahan, JD | 1 |
| Cox, IJ | 1 |
| Azzopardi, D | 1 |
| Cowan, FM | 1 |
| Sargentoni, J | 1 |
| Bell, JD | 1 |
| Bryant, DJ | 1 |
| Edwards, AD | 1 |
| Barkovich, AJ | 1 |
| Baranski, K | 1 |
| Vigneron, D | 1 |
| Partridge, JC | 1 |
| Hallam, DK | 1 |
| Hajnal, BL | 1 |
| Ferriero, DM | 1 |
| Delmas, F | 1 |
| Beloeil, JC | 1 |
| van der Sanden, BP | 1 |
| Nicolay, K | 1 |
| Gillet, B | 1 |
| Eriskat, J | 1 |
| Stoffel, M | 1 |
| Rinecker, M | 1 |
| Frykholm, P | 1 |
| Långström, B | 1 |
| Persson, L | 1 |
| Valtysson, J | 1 |
| Watanabe, Y | 1 |
| Enblad, P | 1 |
| Vannucci, RC | 1 |
| Mujsce, DJ | 1 |
| Caron, MJ | 1 |
| Hovda, DA | 1 |
| Becker, DP | 1 |
| Siesjö, BK | 1 |
| Ingvar, M | 1 |
| Wieloch, T | 1 |
| Yao, H | 1 |
| Sadoshima, S | 1 |
| Nishimura, Y | 1 |
| Fujii, K | 1 |
| Oshima, M | 1 |
| Ishitsuka, T | 1 |
| Fujishima, M | 1 |
| Dauberschmidt, R | 1 |
| Förster, I | 1 |
| Griess, B | 1 |
| Mrochen, H | 1 |
| Schreiber, G | 1 |
| Klages, G | 1 |
| Kynast, J | 1 |
| Dressler, C | 1 |
| Schönbeck, S | 1 |
| Lun, A | 1 |
| Edgren, E | 1 |
| Hedstrand, U | 1 |
| Nordin, M | 1 |
| Rydin, E | 1 |
| Ronquist, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus[NCT00858884] | 68 participants (Actual) | Interventional | 2006-08-31 | Completed | |||
| Evaluation of Prognosis Factors of Neurological Evolution in Cardiac Arrest : Prospective Study of Routine Care[NCT02849561] | 82 participants (Actual) | Interventional | 2014-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for lactic acid and Brain Damage, Chronic
| Article | Year |
|---|---|
Lactate, glucose and energy metabolism in the ischemic brain (Review).
Topics: Acidosis, Lactic; Anaerobiosis; Animals; Brain; Brain Damage, Chronic; Brain Ischemia; Corticosteron | 2002 |
Cerebral metabolic studies in vivo by combined 1H/31P and 1H/13C NMR spectroscopic methods.
Topics: Acid-Base Equilibrium; Amino Acids; Ammonia; Animals; Brain; Brain Damage, Chronic; Brain Ischemia; | 1993 |
Effect of glucose on perinatal hypoxic-ischemic brain damage.
Topics: Aging; Animals; Animals, Newborn; Brain; Brain Damage, Chronic; Brain Ischemia; Glucose; Humans; Hyp | 1992 |
Changes in the treatment of head injury.
Topics: Amino Acids; Animals; Brain Damage, Chronic; Brain Injuries; Critical Care; Free Radicals; Humans; I | 1991 |
Cellular and molecular events underlying epileptic brain damage.
Topics: Acidosis; Animals; Brain; Brain Damage, Chronic; Calcium; Cell Survival; Cerebral Infarction; Electr | 1986 |
2 trials available for lactic acid and Brain Damage, Chronic
| Article | Year |
|---|---|
Endovascular treatment of intracranial aneurysms with matrix detachable coils: immediate posttreatment results from a prospective multicenter registry.
Topics: Adolescent; Adult; Aged; Aneurysm, Ruptured; Brain Damage, Chronic; Cerebral Angiography; Coated Mat | 2006 |
Traumatic brain tissue acidosis: experimental and clinical studies.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Blood-Brain Barrier; Brain Damage, Chronic; Head Injuries, | 1993 |
20 other studies available for lactic acid and Brain Damage, Chronic
| Article | Year |
|---|---|
Cerebral glucose metabolism after traumatic brain injury in the rat studied by 13C-glucose and microdialysis.
Topics: Anaerobiosis; Animals; Blood Glucose; Brain Damage, Chronic; Brain Injuries; Carbon Radioisotopes; E | 2011 |
Prostacyclin infusion may prevent secondary damage in pericontusional brain tissue.
Topics: Blood Glucose; Brain Concussion; Brain Damage, Chronic; Brain Edema; Brain Ischemia; Epoprostenol; F | 2011 |
Hypothermia attenuates circulatory shock and cerebral ischemia in experimental heatstroke.
Topics: Animals; Brain Chemistry; Brain Damage, Chronic; Brain Ischemia; Cerebrovascular Circulation; Corpus | 2003 |
Cerebral lactic acidosis correlates with neurological impairment in MELAS.
Topics: Acidosis, Lactic; Astrocytes; Biological Transport; Brain Damage, Chronic; Cerebral Ventricles; Huma | 2004 |
[Cerebrospinal fluid findings in brain atrophies detected by computer tomography].
Topics: Alcoholism; Atrophy; Brain; Brain Damage, Chronic; Brain Ischemia; Cerebrospinal Fluid Proteins; Enc | 1984 |
Cerebral dysgenesis and lactic acidemia: an MRI/MRS phenotype associated with pyruvate dehydrogenase deficiency.
Topics: Acidosis, Lactic; Agenesis of Corpus Callosum; Brain; Brain Damage, Chronic; Brain Diseases, Metabol | 1994 |
Early ischaemia after severe head injury. Preliminary results in patients with diffuse brain injuries.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Flow Velocity; Brain; Brain Concussion; Brain Dama | 1993 |
Swelling, intracellular acidosis, and damage of glial cells.
Topics: Acid-Base Equilibrium; Animals; Arachidonic Acid; Brain Damage, Chronic; Brain Edema; Brain Ischemia | 1996 |
Use of brain lactate levels to predict outcome after perinatal asphyxia.
Topics: Asphyxia Neonatorum; Brain Chemistry; Brain Damage, Chronic; Cerebral Palsy; Cerebrovascular Circula | 1996 |
Neurometabolism of active neuropsychiatric lupus determined with proton MR spectroscopy.
Topics: Adult; Aspartic Acid; Brain; Brain Damage, Chronic; Brain Ischemia; Brain Mapping; Choline; Creatine | 1997 |
Metabolic stroke in carbamyl phosphate synthetase deficiency.
Topics: Ammonia; Brain Damage, Chronic; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cerebrovascula | 1997 |
Clinical studies on three cases of the interval form of carbon monoxide poisoning: serial proton magnetic resonance spectroscopy as a prognostic predictor.
Topics: Adult; Akinetic Mutism; Aspartic Acid; Brain; Brain Damage, Chronic; Brain Mapping; Carbon Monoxide | 1998 |
Relation between proton magnetic resonance spectroscopy within 18 hours of birth asphyxia and neurodevelopment at 1 year of age.
Topics: Asphyxia Neonatorum; Brain; Brain Damage, Chronic; Creatine; Female; Humans; Image Processing, Compu | 1999 |
Proton MR spectroscopy for the evaluation of brain injury in asphyxiated, term neonates.
Topics: Aspartic Acid; Asphyxia Neonatorum; Brain; Brain Damage, Chronic; Choline; Creatine; Developmental D | 1999 |
Two-voxel localization sequence for in vivo two-dimensional homonuclear correlation spectroscopy.
Topics: Animals; Brain; Brain Damage, Chronic; Brain Ischemia; Dominance, Cerebral; Energy Metabolism; Image | 2001 |
Interstitial lactate in the peritraumatic penumbra of rat brain.
Topics: Animals; Brain Damage, Chronic; Brain Edema; Brain Injuries; Cerebral Cortex; Lactic Acid; Male; Nec | 2000 |
Increase of interstitial glycerol reflects the degree of ischaemic brain damage: a PET and microdialysis study in a middle cerebral artery occlusion-reperfusion primate model.
Topics: Animals; Brain Damage, Chronic; Extracellular Space; Glutamic Acid; Glycerol; Infarction, Middle Cer | 2001 |
Cerebrospinal fluid lactate in patients with diabetes mellitus and hypoglycaemic coma.
Topics: Brain Damage, Chronic; Diabetes Mellitus; Diabetic Coma; Diabetic Neuropathies; Female; Humans; Hypo | 1989 |
[Value of clinico-chemical studies of ventricular cerebrospinal fluid in patients with severe craniocerebral trauma].
Topics: Brain Damage, Chronic; Brain Injuries; Humans; Lactates; Lactic Acid; Prognosis | 1987 |
Prediction of outcome after cardiac arrest.
Topics: Adenylate Kinase; Adult; Aged; Brain Damage, Chronic; Coma; Electroencephalography; Female; Glutathi | 1987 |