lactic acid has been researched along with Bone Loss, Osteoclastic in 33 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here we show that bone resorption of differentiated osteoclasts heavily relies on increased aerobic glycolysis and glycolysis-derived lactate production." | 1.56 | Metabolic reprogramming of osteoclasts represents a therapeutic target during the treatment of osteoporosis. ( Adam, S; Böhm, C; Böttcher, M; Faas, M; Hofmann, J; Krishnacoumar, B; Krönke, G; Mougiakakos, D; Müller, DIH; Schett, G; Scholtysek, C; Sonnewald, U; Stoll, C; Taubmann, J, 2020) |
| "Osthole can inhibit bone resorption and raise the level of nutrition metabolism of femurs tissue." | 1.42 | [Inhibition of osthole for resorption of rats femur tissue in vitro]. ( Chen, KM; Gao, YH; Ma, XN; Ren, XM; Shi, WG; Yan, LJ; Zhou, J, 2015) |
| "PLGA/TiO2 scaffolds exhibited the least bone resorption (4." | 1.40 | In vivo comparative model of oxygen plasma and nanocomposite particles on PLGA membranes for guided bone regeneration processes to be applied in pre-prosthetic surgery: a pilot study. ( Barouk, B; Barranco, A; Batista, A; Cabezas-Talavero, J; Castillo-Dalí, G; Castillo-Oyagüe, R; Cayón, RV; Gutiérrez-Pérez, JL; Llorens, A; Lynch, CD; Saffar, JL; Sloan, AJ; Terriza, A; Torres-Lagares, D, 2014) |
| "Alveolar bone turnover has two phases: bone resorption and formation." | 1.28 | The lactic acid and citric acid content in the gingival fluid of orthodontic patients. ( Iizuka, T; Iwata, T; Miyajima, K; Ohno, Y; Tanida, K, 1991) |
| "Lactic acid release was increased during the 96 hr of incubation in proportion to the calcium release in the media." | 1.27 | Forskolin-induced bone resorption in neonatal mouse calvaria in vitro. ( Gunasekaran, S; Hall, GE; Kenny, AD, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (18.18) | 18.7374 |
| 1990's | 8 (24.24) | 18.2507 |
| 2000's | 10 (30.30) | 29.6817 |
| 2010's | 7 (21.21) | 24.3611 |
| 2020's | 2 (6.06) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, Z | 1 |
| Chen, Y | 1 |
| Zou, J | 1 |
| Gao, S | 1 |
| Wu, D | 1 |
| Li, X | 1 |
| Hu, N | 1 |
| Zhao, J | 1 |
| Huang, W | 1 |
| Chen, H | 1 |
| Taubmann, J | 1 |
| Krishnacoumar, B | 1 |
| Böhm, C | 1 |
| Faas, M | 1 |
| Müller, DIH | 1 |
| Adam, S | 1 |
| Stoll, C | 1 |
| Böttcher, M | 1 |
| Mougiakakos, D | 1 |
| Sonnewald, U | 1 |
| Hofmann, J | 1 |
| Schett, G | 1 |
| Krönke, G | 1 |
| Scholtysek, C | 1 |
| Castillo-Dalí, G | 1 |
| Castillo-Oyagüe, R | 1 |
| Terriza, A | 1 |
| Saffar, JL | 1 |
| Batista, A | 1 |
| Barranco, A | 1 |
| Cabezas-Talavero, J | 1 |
| Lynch, CD | 1 |
| Barouk, B | 1 |
| Llorens, A | 1 |
| Sloan, AJ | 1 |
| Cayón, RV | 1 |
| Gutiérrez-Pérez, JL | 1 |
| Torres-Lagares, D | 1 |
| Tsuchiya, Y | 1 |
| Sakuraba, K | 1 |
| Ochi, E | 1 |
| Zhou, J | 2 |
| Ma, XN | 2 |
| Gao, YH | 2 |
| Yan, JL | 1 |
| Shi, WG | 2 |
| Xian, CJ | 1 |
| Chen, KM | 2 |
| Yoneda, T | 1 |
| Hiasa, M | 1 |
| Nagata, Y | 1 |
| Okui, T | 1 |
| White, F | 1 |
| Ren, XM | 1 |
| Yan, LJ | 1 |
| Kishimoto, TK | 1 |
| Ferrari, JD | 1 |
| LaMothe, RA | 1 |
| Kolte, PN | 1 |
| Griset, AP | 1 |
| O'Neil, C | 1 |
| Chan, V | 1 |
| Browning, E | 1 |
| Chalishazar, A | 1 |
| Kuhlman, W | 1 |
| Fu, FN | 1 |
| Viseux, N | 1 |
| Altreuter, DH | 1 |
| Johnston, L | 1 |
| Maldonado, RA | 1 |
| Morten, KJ | 1 |
| Badder, L | 1 |
| Knowles, HJ | 1 |
| Yamaguchi, M | 6 |
| Uchiyama, S | 2 |
| Tsukamoto, Y | 1 |
| Dani, BA | 1 |
| Raiche, AT | 1 |
| Puleo, DA | 1 |
| DeLuca, PP | 1 |
| Mackool, R | 1 |
| Yim, J | 1 |
| McCarthy, JG | 1 |
| Lai, YL | 1 |
| Zizelmann, C | 1 |
| Schoen, R | 1 |
| Metzger, MC | 1 |
| Schmelzeisen, R | 1 |
| Schramm, A | 1 |
| Dott, B | 1 |
| Bormann, KH | 1 |
| Gellrich, NC | 1 |
| Polimeni, G | 1 |
| Koo, KT | 1 |
| Pringle, GA | 1 |
| Agelan, A | 1 |
| Safadi, FF | 1 |
| Wikesjö, UM | 1 |
| Shinoda, H | 1 |
| Adamek, G | 1 |
| Felix, R | 2 |
| Fleisch, H | 3 |
| Schenk, R | 2 |
| Hagan, P | 1 |
| Malone, JD | 1 |
| Kahn, AJ | 1 |
| Teitelbaum, SL | 1 |
| Schliephake, H | 1 |
| Neukam, FW | 1 |
| Hutmacher, D | 1 |
| Wüstenfeld, H | 1 |
| Hashizume, M | 1 |
| Gatti, A | 1 |
| Monari, E | 1 |
| Tanza, D | 1 |
| Betti, V | 1 |
| Lewandrowski, KU | 1 |
| Bondre, SP | 1 |
| Gresser, JD | 1 |
| Wise, DL | 1 |
| Tomford, WW | 1 |
| Trantolo, DJ | 1 |
| Ma, ZJ | 1 |
| Fushimi, T | 1 |
| Crump, TB | 1 |
| Wimmer, KL | 1 |
| Reinhardt, AL | 1 |
| Schmid, MJ | 1 |
| Meyer, CR | 1 |
| Robinson, DH | 1 |
| Marx, DB | 1 |
| Bhattacharyya, I | 1 |
| Reinhardt, RA | 1 |
| Segawa, Y | 1 |
| Shimokawa, N | 1 |
| Tsuzuike, N | 1 |
| Tagashira, E | 1 |
| Miyajima, K | 1 |
| Ohno, Y | 1 |
| Iwata, T | 1 |
| Tanida, K | 1 |
| Iizuka, T | 1 |
| Moore, JW | 1 |
| Brekke, JH | 1 |
| Magnusson, I | 1 |
| Stenberg, WV | 1 |
| Batich, C | 1 |
| Egelberg, J | 1 |
| Gunasekaran, S | 1 |
| Hall, GE | 1 |
| Kenny, AD | 1 |
| Lafeber, FP | 1 |
| Schaefer, HI | 1 |
| Herrmann-Erlee, MP | 1 |
| Wendelaar Bonga, SE | 1 |
| Yamada, S | 1 |
| Guenther, HL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I Pilot Trial to Study the Safety and Efficacy of Concomitant Radiotherapy and Zoledronic Acid for the Palliation of Bone Metastases From Breast Cancer, Prostate Cancer and Lung Cancer[NCT00264420] | Phase 1 | 4 participants (Actual) | Interventional | 2005-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for lactic acid and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Contribution of acidic extracellular microenvironment of cancer-colonized bone to bone pain.
Topics: Acid Sensing Ion Channels; Analgesics; Bone and Bones; Bone Neoplasms; Bone Resorption; Gene Express | 2015 |
1 trial available for lactic acid and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
[Evaluation of the biocompatibility of grafts for bone defects].
Topics: Alveolar Ridge Augmentation; Alveolectomy; Alveoloplasty; Animals; Biocompatible Materials; Bone Res | 1999 |
31 other studies available for lactic acid and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Lactate Mediates the Bone Anabolic Effect of High-Intensity Interval Training by Inducing Osteoblast Differentiation.
Topics: Anabolic Agents; Animals; Bone Density; Bone Resorption; Cell Differentiation; Female; High-Intensit | 2023 |
Metabolic reprogramming of osteoclasts represents a therapeutic target during the treatment of osteoporosis.
Topics: Animals; Antimetabolites; Bone Resorption; Cells, Cultured; Deoxyglucose; Female; Glycolysis; Lactic | 2020 |
In vivo comparative model of oxygen plasma and nanocomposite particles on PLGA membranes for guided bone regeneration processes to be applied in pre-prosthetic surgery: a pilot study.
Topics: Animals; Bone Diseases; Bone Regeneration; Bone Resorption; Calcification, Physiologic; Coated Mater | 2014 |
Effect of eccentric contractions of elbow flexor on bone formation and resorption markers.
Topics: Acid Phosphatase; Adult; Biomarkers; Bone Resorption; Elbow Joint; Humans; Insulin-Like Growth Facto | 2014 |
Sinusoidal electromagnetic fields promote bone formation and inhibit bone resorption in rat femoral tissues in vitro.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Bone Resorption; Electromagnetic Fields; Femur; Gen | 2016 |
[Inhibition of osthole for resorption of rats femur tissue in vitro].
Topics: Acid Phosphatase; Animals; Bone Resorption; Coumarins; Estradiol; Femur; Glucose; Lactic Acid; Male; | 2015 |
Improving the efficacy and safety of biologic drugs with tolerogenic nanoparticles.
Topics: Adalimumab; Anaphylaxis; Animals; Arthritis, Experimental; Bone Resorption; Drug Delivery Systems; F | 2016 |
Differential regulation of HIF-mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts.
Topics: Adaptation, Physiological; Adenosine Triphosphate; Basic Helix-Loop-Helix Transcription Factors; Bon | 2013 |
Inhibitory effect of menaquinone-7 (vitamin K2) on the bone-resorbing factors-induced bone resorption in elderly female rat femoral tissues in vitro.
Topics: Aging; Animals; Bone and Bones; Bone Resorption; Calcium; Cells, Cultured; Culture Media; Dinoprosto | 2003 |
A study of the antiresorptive activity of salmon calcitonin microspheres using cultured osteoclastic cells.
Topics: Animals; Bone and Bones; Bone Marrow Cells; Bone Resorption; Calcitonin; Cattle; Cell Division; Cell | 2002 |
beta-Cryptoxanthin stimulates bone formation and inhibits bone resorption in tissue culture in vitro.
Topics: Alkaline Phosphatase; Animals; Anticarcinogenic Agents; beta Carotene; Bone Resorption; Calcium; Cry | 2004 |
Delayed degradation in a resorbable plating system.
Topics: Absorbable Implants; Acrocephalosyndactylia; Bone Plates; Bone Resorption; Bone Screws; Craniosynost | 2006 |
Phytocomponent p-hydroxycinnamic acid stimulates bone formation and inhibits bone resorption in rat femoral tissues in vitro.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Bone Resorption; Calcium; Cholecalciferol; Coumaric | 2006 |
Bone formation after sinus augmentation with engineered bone.
Topics: Alveolar Ridge Augmentation; Biocompatible Materials; Bone Density; Bone Resorption; Bone Transplant | 2007 |
Histopathological observations of a polylactic acid-based device intended for guided bone/tissue regeneration.
Topics: Absorbable Implants; Animals; Bone Resorption; Foreign-Body Reaction; Guided Tissue Regeneration; La | 2008 |
Structure-activity relationships of various bisphosphonates.
Topics: Alkaline Phosphatase; Animals; Bone and Bones; Bone Resorption; Calcification, Physiologic; Calcium | 1983 |
Dissociation of organic acid secretion from macrophage mediated bone resorption.
Topics: Animals; Bone Resorption; Cells, Cultured; Citrates; Citric Acid; Lactates; Lactic Acid; Macrophages | 1982 |
Experimental transplantation of hydroxylapatite-bone composite grafts.
Topics: Angiography; Animals; Anthraquinones; Bone Regeneration; Bone Resorption; Bone Transplantation; Dent | 1995 |
Effect of parathyroid hormone and interleukin-1 alpha in osteoblastic MC3T3-E1 cells: interaction with beta-alanyl-L-histidinato zinc.
Topics: Alkaline Phosphatase; Bone Resorption; Carnosine; Cell Line; Dinoprostone; Dipeptides; Glucose; Inte | 1994 |
Improved osteoconduction of cortical bone grafts by biodegradable foam coating.
Topics: Absorbable Implants; Animals; Bone and Bones; Bone Cements; Bone Regeneration; Bone Remodeling; Bone | 1999 |
Bone damage--more than just nukes involved.
Topics: Acidosis, Lactic; Anti-HIV Agents; Bone Resorption; HIV Infections; Humans; Lactic Acid; Life Style; | 2001 |
Anabolic effect of phosphogenistein and phosphodaidzein on bone components in rat femoral-metaphyseal tissues in vitro.
Topics: Alkaline Phosphatase; Animals; Bone Resorption; Calcium; Culture Techniques; Cycloheximide; Dinopros | 2002 |
Effects of locally-delivered human macrophage products and estrogen on murine inflammatory bone resorption.
Topics: Analysis of Variance; Animals; Bone Resorption; Cell Count; Disease Models, Animal; Down-Regulation; | 2002 |
Inhibitory effect of beta-alanyl-L-histidinato zinc on bone resorption in tissue culture.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Anti-Ulcer Agents; Bone and Bones; Bone Resorption; | 1992 |
The lactic acid and citric acid content in the gingival fluid of orthodontic patients.
Topics: Adolescent; Bone Remodeling; Bone Resorption; Citrates; Citric Acid; Female; Gingival Crevicular Flu | 1991 |
Foreign body giant cell reaction related to placement of tetracycline-treated polylactic acid: report of 18 cases.
Topics: Bone Resorption; Dry Socket; Foreign-Body Reaction; Giant Cells; Humans; Lactates; Lactic Acid; Poly | 1990 |
Connective tissue repair in circumferential periodontal defects in dogs following use of a biodegradable membrane.
Topics: Alveolar Process; Animals; Bicuspid; Biocompatible Materials; Biodegradation, Environmental; Bone Re | 1990 |
Forskolin-induced bone resorption in neonatal mouse calvaria in vitro.
Topics: Acetazolamide; Acid Phosphatase; Alkaline Phosphatase; Animals; Animals, Newborn; Bone Resorption; C | 1986 |
Parathyroid hormone-like effects of rainbow trout Stannius products on bone resorption of embryonic mouse calvaria in vitro.
Topics: Animals; Bone and Bones; Bone Resorption; Calcium; Dose-Response Relationship, Drug; Endocrine Gland | 1986 |
Effect of halogenmethylenebisphosphonates on bone cells in culture and on bone resorption in vivo.
Topics: Alkaline Phosphatase; Animals; Bone and Bones; Bone Resorption; Cells, Cultured; Diphosphonates; Fat | 1986 |
The effect of pulsed electromagnetic fields on bone cell metabolism and calvaria resorption in vitro, and on calcium metabolism in the live rat.
Topics: Alkaline Phosphatase; Animals; Bone and Bones; Bone Development; Bone Resorption; Calcium; Cell Divi | 1985 |