lactic acid has been researched along with Blunt Injuries in 23 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hyperglycemia is associated with mortality after trauma; however, few studies have simultaneously investigated the association of depth of shock and acute hyperglycemia." | 1.62 | The Bitter and the Sweet: Relationship of Lactate, Glucose, and Mortality After Severe Blunt Trauma. ( Galvagno, SM; Massey, MS; Mazzeffi, MA; Richards, JE; Rock, P; Scalea, TM, 2021) |
| "Early hyperglycemia is associated with multiple organ failure (MOF) after traumatic injury; however, few studies have considered the contribution of depth of clinical shock." | 1.48 | Does Lactate Affect the Association of Early Hyperglycemia and Multiple Organ Failure in Severely Injured Blunt Trauma Patients? ( Galvagno, SM; Mazzeffi, MA; Richards, JE; Rock, P; Scalea, TM, 2018) |
| "42." | 1.42 | Severe blunt thoracic trauma: differences between adults and children in a level I trauma centre. ( den Hollander, D; Laing, GL; Muckart, DJ; Rodseth, RN; Skinner, DL, 2015) |
| "No lactic acidosis was induced by the intravenous infusion of 280 mM L-lactate." | 1.34 | Effect of lactate therapy upon cognitive deficits after traumatic brain injury in the rat. ( Bullock, MR; Hamm, RJ; Harvey, HB; Holloway, R; Levasseur, JE; Rice, AC; Sun, D; Zhou, Z, 2007) |
| "Prospective, observational study of trauma patients in a Level 1 trauma center." | 1.32 | Ethanol and illicit drugs do not affect the diagnostic utility of base deficit and lactate in differentiating minor from major injury in trauma patients. ( Baron, BJ; Lucchesi, M; Sinert, R; Yadav, K; Zehtabchi, S, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 7 (30.43) | 29.6817 |
| 2010's | 11 (47.83) | 24.3611 |
| 2020's | 3 (13.04) | 2.80 |
| Authors | Studies |
|---|---|
| Özakın, E | 1 |
| Özcan Yazlamaz, N | 1 |
| Baloğlu Kaya, F | 1 |
| Çanakçı, ME | 1 |
| Bilgin, M | 1 |
| Poirier, M | 1 |
| Stillion, JR | 1 |
| Boysen, SR | 1 |
| Richards, JE | 2 |
| Mazzeffi, MA | 2 |
| Massey, MS | 1 |
| Rock, P | 2 |
| Galvagno, SM | 2 |
| Scalea, TM | 3 |
| Bellomy, ML | 1 |
| Freundlich, RE | 1 |
| Hamada, SR | 1 |
| Rosa, A | 1 |
| Gauss, T | 1 |
| Desclefs, JP | 1 |
| Raux, M | 1 |
| Harrois, A | 1 |
| Follin, A | 1 |
| Cook, F | 1 |
| Boutonnet, M | 2 |
| Attias, A | 1 |
| Ausset, S | 1 |
| Dhonneur, G | 1 |
| Duranteau, J | 2 |
| Langeron, O | 1 |
| Paugam-Burtz, C | 1 |
| Pirracchio, R | 1 |
| de St Maurice, G | 1 |
| Vigué, B | 1 |
| Rouquette, A | 1 |
| Bekker, W | 1 |
| Hernandez, MC | 1 |
| Zielinski, MD | 1 |
| Kong, VY | 1 |
| Laing, GL | 3 |
| Bruce, JL | 1 |
| Manchev, V | 1 |
| Smith, MTD | 1 |
| Clarke, DL | 1 |
| Bar-Or, D | 1 |
| Salottolo, KM | 1 |
| Orlando, A | 1 |
| Mains, CW | 1 |
| Bourg, P | 1 |
| Offner, PJ | 1 |
| Harris, DG | 1 |
| Rabin, J | 1 |
| Kufera, JA | 1 |
| Taylor, BS | 1 |
| Sarkar, R | 1 |
| O'Connor, JV | 1 |
| Crawford, RS | 1 |
| Skinner, DL | 2 |
| Rodseth, RN | 2 |
| Ryan, L | 1 |
| Hardcastle, TC | 1 |
| Muckart, DJ | 2 |
| den Hollander, D | 1 |
| Gale, SC | 1 |
| Kocik, JF | 1 |
| Creath, R | 1 |
| Crystal, JS | 1 |
| Dombrovskiy, VY | 1 |
| Callaway, DW | 1 |
| Shapiro, NI | 1 |
| Donnino, MW | 1 |
| Baker, C | 1 |
| Rosen, CL | 1 |
| Gryth, D | 1 |
| Rocksén, D | 1 |
| Drobin, D | 1 |
| Druid, H | 1 |
| Weitzberg, E | 1 |
| Bursell, J | 1 |
| Olsson, LG | 1 |
| Arborelius, UP | 1 |
| Ouellet, JF | 1 |
| Roberts, DJ | 1 |
| Tiruta, C | 1 |
| Kirkpatrick, AW | 1 |
| Mercado, M | 1 |
| Trottier, V | 1 |
| Dixon, E | 1 |
| Feliciano, DV | 1 |
| Ball, CG | 1 |
| Schulman, AM | 1 |
| Claridge, JA | 1 |
| Young, JS | 1 |
| Zehtabchi, S | 2 |
| Baron, BJ | 1 |
| Sinert, R | 2 |
| Yadav, K | 1 |
| Lucchesi, M | 1 |
| Goldman, M | 1 |
| Kapitanyan, R | 1 |
| Ballas, J | 1 |
| Bartnik, BL | 1 |
| Lee, SM | 1 |
| Hovda, DA | 1 |
| Sutton, RL | 1 |
| Holloway, R | 1 |
| Zhou, Z | 1 |
| Harvey, HB | 1 |
| Levasseur, JE | 1 |
| Rice, AC | 1 |
| Sun, D | 1 |
| Hamm, RJ | 1 |
| Bullock, MR | 1 |
| Cipolle, MD | 1 |
| Pasquale, MD | 1 |
| Shearer, J | 1 |
| Caldwell, M | 1 |
| Cerra, F | 1 |
| Dunham, CM | 1 |
| Watson, LA | 1 |
| Cooper, C | 1 |
| Hiraide, A | 1 |
| Katayama, M | 1 |
| Sugimoto, H | 1 |
| Yoshioka, T | 1 |
| Sugimoto, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| "External Validation of the Clinical Pre-hospital Red- Flag Alert for Activation of Intra-hospital Hemorrhage Control Response in Blunt Trauma. A Prospective Multicentric Study"[NCT05820217] | 630 participants (Anticipated) | Observational | 2023-05-10 | Not yet recruiting | |||
| Evaluation of a Transfusion Therapy Using Whole Blood Versus Fractionated Blood Products in the Management of Coagulopathy in Patients Admitted to Hospital for Acute Traumatic Hemorrhage[NCT04431999] | Phase 3 | 200 participants (Anticipated) | Interventional | 2021-12-04 | Recruiting | ||
| Fluid Resuscitation Optimization in Surgical Trauma Patients (FROST)[NCT02742974] | 196 participants (Anticipated) | Interventional | 2015-12-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for lactic acid and Blunt Injuries
| Article | Year |
|---|---|
Effect of 3-hydroxybutyrate on posttraumatic metabolism in man.
Topics: 3-Hydroxybutyric Acid; Accidents, Traffic; Adult; Amino Acids; Fatty Acids, Nonesterified; Humans; H | 1991 |
22 other studies available for lactic acid and Blunt Injuries
| Article | Year |
|---|---|
Lactate and base deficit combination score for predicting blood transfusion need in blunt multi-trauma patients.
Topics: Adult; Blood Transfusion; Female; Glasgow Coma Scale; Humans; Lactic Acid; Male; Multiple Trauma; Sh | 2022 |
Markers of tissue perfusion and their relation to mortality in dogs with blunt trauma.
Topics: Animals; Dog Diseases; Dogs; Electrolytes; Lactic Acid; Prospective Studies; Retrospective Studies; | 2023 |
The Bitter and the Sweet: Relationship of Lactate, Glucose, and Mortality After Severe Blunt Trauma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Blood Glucose; Female; Hospital Mortality; H | 2021 |
Does Lactate Affect the Association of Early Hyperglycemia and Multiple Organ Failure in Severely Injured Blunt Trauma Patients?
Topics: Adult; Biomarkers; Blood Glucose; Cohort Studies; Female; Humans; Hyperglycemia; Injury Severity Sco | 2018 |
Hyperglycemia and Elevated Lactate in Trauma: Where Do We Go From Here?
Topics: Humans; Hyperglycemia; Lactic Acid; Multiple Organ Failure; Wounds, Nonpenetrating | 2018 |
Development and validation of a pre-hospital "Red Flag" alert for activation of intra-hospital haemorrhage control response in blunt trauma.
Topics: Adult; Blood Transfusion; Chi-Square Distribution; Cohort Studies; Emergency Medical Services; Femal | 2018 |
Development and validation of a pre-hospital "Red Flag" alert for activation of intra-hospital haemorrhage control response in blunt trauma.
Topics: Adult; Blood Transfusion; Chi-Square Distribution; Cohort Studies; Emergency Medical Services; Femal | 2018 |
Development and validation of a pre-hospital "Red Flag" alert for activation of intra-hospital haemorrhage control response in blunt trauma.
Topics: Adult; Blood Transfusion; Chi-Square Distribution; Cohort Studies; Emergency Medical Services; Femal | 2018 |
Development and validation of a pre-hospital "Red Flag" alert for activation of intra-hospital haemorrhage control response in blunt trauma.
Topics: Adult; Blood Transfusion; Chi-Square Distribution; Cohort Studies; Emergency Medical Services; Femal | 2018 |
Defining an intra-operative blunt mesenteric injury grading system and its use as a tool for surgical-decision making.
Topics: Abdominal Injuries; Adult; Female; Hemoglobins; Humans; Injury Severity Score; International Normali | 2019 |
Association between a geriatric trauma resuscitation protocol using venous lactate measurements and early trauma surgeon involvement and mortality risk.
Topics: Aged, 80 and over; Colorado; Cooperative Behavior; Early Medical Intervention; Female; Geriatric Ass | 2013 |
A new aortic injury score predicts early rupture more accurately than clinical assessment.
Topics: Adult; Aged; Aorta, Thoracic; Aortic Rupture; Aortography; Area Under Curve; Biomarkers; Decision Su | 2015 |
Blunt cardiac injury in critically ill trauma patients: a single centre experience.
Topics: Adult; Biomarkers; Critical Care; Critical Illness; Electrocardiography; Female; Heart Injuries; Hos | 2015 |
Severe blunt thoracic trauma: differences between adults and children in a level I trauma centre.
Topics: Accidents, Traffic; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Child; Child, Preschool | 2015 |
A comparison of initial lactate and initial base deficit as predictors of mortality after severe blunt trauma.
Topics: Acidosis; Adult; Aged; Biomarkers; Female; Hospital Mortality; Humans; Lactic Acid; Logistic Models; | 2016 |
Serum lactate and base deficit as predictors of mortality in normotensive elderly blunt trauma patients.
Topics: Acid-Base Imbalance; Aged; Aged, 80 and over; Area Under Curve; Comorbidity; Female; Hospital Mortal | 2009 |
Effects of fluid resuscitation with hypertonic saline dextrane or Ringer's acetate after nonhemorrhagic shock caused by pulmonary contusion.
Topics: Acute Lung Injury; Animals; Blood Pressure; Contusions; Dextrans; Disease Models, Animal; Extravascu | 2010 |
Admission base deficit and lactate levels in Canadian patients with blunt trauma: are they useful markers of mortality?
Topics: Acid-Base Imbalance; Adult; Aged; Alberta; Analysis of Variance; Biomarkers; Blood Gas Analysis; Coh | 2012 |
Young versus old: factors affecting mortality after blunt traumatic injury.
Topics: Adolescent; Adult; Age Factors; Aged; Female; Humans; Injury Severity Score; Lactic Acid; Male; Midd | 2002 |
Ethanol and illicit drugs do not affect the diagnostic utility of base deficit and lactate in differentiating minor from major injury in trauma patients.
Topics: Acid-Base Imbalance; Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Emergency Medicin | 2004 |
Diagnostic performance of serial haematocrit measurements in identifying major injury in adult trauma patients.
Topics: Adult; Female; Hematocrit; Hemorrhage; Humans; Infusions, Intravenous; Injury Severity Score; Lactic | 2006 |
The fate of glucose during the period of decreased metabolism after fluid percussion injury: a 13C NMR study.
Topics: Animals; Brain Injuries; Carbon Isotopes; Cerebral Cortex; Down-Regulation; Free Radicals; Glucose; | 2007 |
Effect of lactate therapy upon cognitive deficits after traumatic brain injury in the rat.
Topics: Adenosine Triphosphate; Animals; Brain Injuries; Cerebral Cortex; Cognition; Cognition Disorders; In | 2007 |
Blunt injury augments interleukin-6 but not tumor necrosis factor in isolated, perfused rat hindlimbs.
Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Animals; Hindlimb; In Vitro Techniques; Inflamma | 1994 |
Base deficit level indicating major injury is increased with ethanol.
Topics: Abdominal Injuries; Acid-Base Imbalance; Alcohol Drinking; Cohort Studies; Comorbidity; Ethanol; Eva | 2000 |