lactic acid has been researched along with Bladder Cancer in 19 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bladder cancer 5637 cell lines were treated with the different concentrations of Cinnamaldehyde." | 8.12 | Anticancer Effects of Cinnamaldehyde Through Inhibition of ErbB2/HSF1/LDHA Pathway in 5637 Cell Line of Bladder Cancer. ( Abbasalipourkabir, R; Aminzadeh, Z; Ziamajidi, N, 2022) |
| " In contrast, oral treatment at a dose of 800mg/kg/d exhibited little efficacy whereas severe toxicity existed if the dosage is higher." | 5.43 | High efficacy of intravesical treatment of metformin on bladder cancer in preclinical model. ( Chen, AF; Cheng, Y; Guo, P; Huang, Y; Li, L; Li, X; Liu, Z; Lv, H; Peng, M; Su, Q; Tao, T; Tao, X; Xue, L; Yang, X; Zeng, Q, 2016) |
| "Bladder cancer 5637 cell lines were treated with the different concentrations of Cinnamaldehyde." | 4.12 | Anticancer Effects of Cinnamaldehyde Through Inhibition of ErbB2/HSF1/LDHA Pathway in 5637 Cell Line of Bladder Cancer. ( Abbasalipourkabir, R; Aminzadeh, Z; Ziamajidi, N, 2022) |
| "CircXRN2 is aberrantly downregulated in bladder cancer tissues and cell lines." | 1.91 | CircXRN2 suppresses tumor progression driven by histone lactylation through activating the Hippo pathway in human bladder cancer. ( Chen, X; Fan, M; He, N; Hu, Z; Lin, J; Wang, F; Xiang, J; Xie, B; Zhang, Y; Zhou, X, 2023) |
| "For muscle-invasive bladder cancer (MIBC), treatment includes radical cystectomy, radiotherapy, and chemotherapy; however, the outcome is generally poor." | 1.62 | The Warburg effect as a therapeutic target for bladder cancers and intratumoral heterogeneity in associated molecular targets. ( Allison, SJ; Burns, JE; Hurst, CD; Knowles, MA; Phillips, RM, 2021) |
| "Newly diagnosed bladder cancer patients were recruited." | 1.56 | Gut microbial composition changes in bladder cancer patients: A case-control study in Harbin, China. ( Bao, Y; He, C; Huang, L; Li, B; Ren, M; Shan, Y; Teng, C, 2020) |
| " In contrast, oral treatment at a dose of 800mg/kg/d exhibited little efficacy whereas severe toxicity existed if the dosage is higher." | 1.43 | High efficacy of intravesical treatment of metformin on bladder cancer in preclinical model. ( Chen, AF; Cheng, Y; Guo, P; Huang, Y; Li, L; Li, X; Liu, Z; Lv, H; Peng, M; Su, Q; Tao, T; Tao, X; Xue, L; Yang, X; Zeng, Q, 2016) |
| "Therefore, three bladder cancer cell lines with distinct genetic and molecular backgrounds (T24, 5637 and HT1376) were submitted to hypoxia." | 1.43 | Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation extension. ( Amaro, T; Azevedo, R; Cotton, S; Fernandes, E; Ferreira, JA; Gaiteiro, C; Lima, L; Neves, M; Oliveira, MJ; Palmeira, C; Parreira, B; Peixoto, A; Rangel, M; Reis, CA; Santos, LL; Silva, AM; Soares, J; Tavares, A; Teixeira, F, 2016) |
| "We hypothesized that the progression of bladder cancer could be accompanied by changes in cells glycolytic profile." | 1.42 | The progression from a lower to a higher invasive stage of bladder cancer is associated with severe alterations in glucose and pyruvate metabolism. ( Alves, MG; Conde, VR; Nunes, AR; Oliveira, PF; Pereira, JA; Ramalhosa, E; Rocha, CS; Silva, BM, 2015) |
| "In studies using orthotopic mouse bladder cancer, the tumor loads in R-837-treated mice were significantly lower than those in vehicle-treated or non-treated mice." | 1.36 | Intravesical Toll-like receptor 7 agonist R-837: optimization of its formulation in an orthotopic mouse model of bladder cancer. ( Barberis, A; Carson, DA; Chan, M; Corr, M; Cottam, HB; Crain, B; Hayashi, T; Leoni, L; Maj, R, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 13 (68.42) | 24.3611 |
| 2020's | 4 (21.05) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, B | 1 |
| Lin, J | 1 |
| Chen, X | 1 |
| Zhou, X | 2 |
| Zhang, Y | 1 |
| Fan, M | 1 |
| Xiang, J | 1 |
| He, N | 1 |
| Hu, Z | 1 |
| Wang, F | 1 |
| He, C | 1 |
| Li, B | 1 |
| Huang, L | 1 |
| Teng, C | 1 |
| Bao, Y | 1 |
| Ren, M | 1 |
| Shan, Y | 1 |
| Burns, JE | 1 |
| Hurst, CD | 1 |
| Knowles, MA | 1 |
| Phillips, RM | 1 |
| Allison, SJ | 1 |
| Aminzadeh, Z | 1 |
| Ziamajidi, N | 1 |
| Abbasalipourkabir, R | 1 |
| Todenhöfer, T | 1 |
| Seiler, R | 1 |
| Stewart, C | 1 |
| Moskalev, I | 1 |
| Gao, J | 1 |
| Ladhar, S | 1 |
| Kamjabi, A | 1 |
| Al Nakouzi, N | 1 |
| Hayashi, T | 2 |
| Choi, S | 1 |
| Wang, Y | 3 |
| Frees, S | 1 |
| Daugaard, M | 1 |
| Oo, HZ | 1 |
| Fisel, P | 1 |
| Schwab, M | 1 |
| Schaeffeler, E | 1 |
| Douglas, J | 1 |
| Hennenlotter, J | 1 |
| Bedke, J | 1 |
| Gibb, EA | 1 |
| Fazli, L | 1 |
| Stenzl, A | 1 |
| Black, PC | 1 |
| Li, Y | 1 |
| Zhang, X | 2 |
| Neutsch, L | 2 |
| Wirth, EM | 2 |
| Spijker, S | 2 |
| Pichl, C | 1 |
| Kählig, H | 2 |
| Gabor, F | 2 |
| Wirth, M | 2 |
| Padrão, AI | 1 |
| Oliveira, P | 1 |
| Vitorino, R | 1 |
| Colaço, B | 1 |
| Pires, MJ | 1 |
| Márquez, M | 1 |
| Castellanos, E | 1 |
| Neuparth, MJ | 1 |
| Teixeira, C | 1 |
| Costa, C | 1 |
| Moreira-Gonçalves, D | 1 |
| Cabral, S | 1 |
| Duarte, JA | 1 |
| Santos, LL | 2 |
| Amado, F | 1 |
| Ferreira, R | 1 |
| Wambacher, M | 1 |
| Wu, M | 1 |
| Seto, E | 1 |
| Zhang, J | 1 |
| Conde, VR | 1 |
| Oliveira, PF | 1 |
| Nunes, AR | 1 |
| Rocha, CS | 1 |
| Ramalhosa, E | 1 |
| Pereira, JA | 1 |
| Alves, MG | 1 |
| Silva, BM | 1 |
| Shi, H | 1 |
| Jiang, H | 1 |
| Wang, L | 1 |
| Cao, Y | 2 |
| Liu, P | 2 |
| Xu, X | 2 |
| Sun, L | 1 |
| Niu, H | 2 |
| Zhao, Y | 1 |
| Wang, D | 1 |
| Xu, T | 1 |
| Yang, X | 2 |
| Wang, X | 1 |
| Peng, M | 1 |
| Su, Q | 1 |
| Zeng, Q | 1 |
| Li, L | 1 |
| Liu, Z | 1 |
| Xue, L | 1 |
| Cheng, Y | 1 |
| Huang, Y | 1 |
| Tao, T | 1 |
| Lv, H | 1 |
| Li, X | 1 |
| Tao, X | 1 |
| Guo, P | 1 |
| Chen, AF | 1 |
| Peixoto, A | 1 |
| Fernandes, E | 1 |
| Gaiteiro, C | 1 |
| Lima, L | 1 |
| Azevedo, R | 1 |
| Soares, J | 1 |
| Cotton, S | 1 |
| Parreira, B | 1 |
| Neves, M | 1 |
| Amaro, T | 1 |
| Tavares, A | 1 |
| Teixeira, F | 1 |
| Palmeira, C | 1 |
| Rangel, M | 1 |
| Silva, AM | 1 |
| Reis, CA | 1 |
| Oliveira, MJ | 1 |
| Ferreira, JA | 1 |
| Sudha, T | 1 |
| Bharali, DJ | 1 |
| Yalcin, M | 1 |
| Darwish, NH | 1 |
| Coskun, MD | 1 |
| Keating, KA | 1 |
| Lin, HY | 1 |
| Davis, PJ | 1 |
| Mousa, SA | 1 |
| Crain, B | 1 |
| Corr, M | 1 |
| Chan, M | 1 |
| Cottam, HB | 1 |
| Maj, R | 1 |
| Barberis, A | 1 |
| Leoni, L | 1 |
| Carson, DA | 1 |
| RAMKISSOON, RA | 1 |
| CHAMBERLAIN, NO | 1 |
| BAKER, EL | 1 |
| JENNINGS, ER | 1 |
| Hasuda, K | 1 |
| Kobayashi, H | 1 |
| Taniguchi, S | 1 |
| Baba, T | 1 |
19 other studies available for lactic acid and Bladder Cancer
| Article | Year |
|---|---|
CircXRN2 suppresses tumor progression driven by histone lactylation through activating the Hippo pathway in human bladder cancer.
Topics: Chromatin Immunoprecipitation; Hippo Signaling Pathway; Histones; Humans; Lactic Acid; Nuclear Prote | 2023 |
Gut microbial composition changes in bladder cancer patients: A case-control study in Harbin, China.
Topics: Case-Control Studies; China; Diet; Enzyme-Linked Immunosorbent Assay; Feces; Female; Fruit; Gastroin | 2020 |
The Warburg effect as a therapeutic target for bladder cancers and intratumoral heterogeneity in associated molecular targets.
Topics: Apoptosis; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Gene Knockdown Techniques; Humans; I | 2021 |
Anticancer Effects of Cinnamaldehyde Through Inhibition of ErbB2/HSF1/LDHA Pathway in 5637 Cell Line of Bladder Cancer.
Topics: Acrolein; Cell Line, Tumor; Cell Proliferation; Glucose; Glycolysis; Humans; L-Lactate Dehydrogenase | 2022 |
Selective Inhibition of the Lactate Transporter MCT4 Reduces Growth of Invasive Bladder Cancer.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; DNA Methylation; Gene Expression Regulatio | 2018 |
LHPP suppresses bladder cancer cell proliferation and growth via inactivating AKT/p65 signaling pathway.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin D1; Female; Gene Expression Regulation, | 2019 |
Synergistic targeting/prodrug strategies for intravesical drug delivery--lectin-modified PLGA microparticles enhance cytotoxicity of stearoyl gemcitabine by contact-dependent transfer.
Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Survival; Deoxycytidine; Drug Carriers; Drug | 2013 |
Bladder cancer-induced skeletal muscle wasting: disclosing the role of mitochondria plasticity.
Topics: 1-Naphthylamine; Animals; Apoptosis Regulatory Proteins; Boronic Acids; C-Reactive Protein; Cytokine | 2013 |
UPEC biomimickry at the urothelial barrier: lectin-functionalized PLGA microparticles for improved intravesical chemotherapy.
Topics: Administration, Intravesical; Antineoplastic Agents; Biomimetic Materials; Cell Adhesion; Cell Line, | 2013 |
E2F1 enhances glycolysis through suppressing Sirt6 transcription in cancer cells.
Topics: Binding Sites; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; E2F1 Transcription Factor; Gene E | 2015 |
The progression from a lower to a higher invasive stage of bladder cancer is associated with severe alterations in glucose and pyruvate metabolism.
Topics: Alanine; Alanine Transaminase; Cell Line, Tumor; Disease Progression; Glucose; Glucose Transporter T | 2015 |
Overexpression of monocarboxylate anion transporter 1 and 4 in T24-induced cancer-associated fibroblasts regulates the progression of bladder cancer cells in a 3D microfluidic device.
Topics: Cell Line, Tumor; Coculture Techniques; Fibroblasts; Glycolysis; Humans; Lab-On-A-Chip Devices; Lact | 2015 |
Bladder cancer cells re-educate TAMs through lactate shuttling in the microfluidic cancer microenvironment.
Topics: Animals; Carcinoma, Transitional Cell; Cell Polarity; Coculture Techniques; Humans; Lab-On-A-Chip De | 2015 |
High efficacy of intravesical treatment of metformin on bladder cancer in preclinical model.
Topics: Administration, Intravesical; AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Biomark | 2016 |
Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation extension.
Topics: Adult; Aged; Aged, 80 and over; Antigens, CD; Antigens, Neoplasm; Carbonic Anhydrase IX; Cell Hypoxi | 2016 |
Targeted delivery of cisplatin to tumor xenografts via the nanoparticle component of nano-diamino-tetrac.
Topics: Animals; Antineoplastic Agents; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Cisplatin; | 2017 |
Intravesical Toll-like receptor 7 agonist R-837: optimization of its formulation in an orthotopic mouse model of bladder cancer.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Adjuvants, Immunologic; Administration, Intravesical; Aminoquinol | 2010 |
DIAGNOSTIC SIGNIFICANCE OF URINARY LACTIC ACID DEHYDROGENASE.
Topics: Adenocarcinoma; Albuminuria; Carcinoma, Papillary; Carcinoma, Transitional Cell; Clinical Enzyme Tes | 1964 |
Increased therapeutic efficacy of intra-arterial carboquone chemotherapy on a limb tumor in rats, by using an acidic vehicle adjusted with lactate.
Topics: Animals; Body Weight; Buffers; Carbazilquinone; Carcinoma, Transitional Cell; Extremities; Female; H | 1990 |