lactic acid has been researched along with Bipolar Disorder in 17 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prior work reported elevated gray matter (GM) lactate and Glx (glutamate + glutamine + GABA) concentrations in unmedicated patients with bipolar disorder (BP) compared with healthy controls (HC)." | 9.11 | Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder. ( Dager, SR; Demopulos, C; Dunner, DL; Friedman, SD; Hirashima, F; Lyoo, IK; Parow, A; Renshaw, PF; Stoll, AL, 2004) |
| "Prior work reported elevated gray matter (GM) lactate and Glx (glutamate + glutamine + GABA) concentrations in unmedicated patients with bipolar disorder (BP) compared with healthy controls (HC)." | 5.11 | Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder. ( Dager, SR; Demopulos, C; Dunner, DL; Friedman, SD; Hirashima, F; Lyoo, IK; Parow, A; Renshaw, PF; Stoll, AL, 2004) |
| " Chronic administration of lithium was found to prevent the development of hyperreactivity to mild footshock, while chronic electroconvulsive shock effected a return toward normal behavior." | 1.26 | A pharmacologically pertinent animal model of mania. ( Petty, F; Sherman, AD, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (29.41) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 8 (47.06) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dogan, AE | 1 |
| Yuksel, C | 1 |
| Du, F | 1 |
| Chouinard, VA | 1 |
| Öngür, D | 2 |
| Kuang, H | 1 |
| Duong, A | 1 |
| Jeong, H | 1 |
| Zachos, K | 1 |
| Andreazza, AC | 1 |
| Li, C | 1 |
| Wang, A | 1 |
| Wang, C | 1 |
| Ramamurthy, J | 1 |
| Zhang, E | 1 |
| Guadagno, E | 1 |
| Trakadis, Y | 1 |
| Chu, WJ | 1 |
| Delbello, MP | 1 |
| Jarvis, KB | 1 |
| Norris, MM | 1 |
| Kim, MJ | 1 |
| Weber, W | 1 |
| Lee, JH | 1 |
| Strakowski, SM | 1 |
| Adler, CM | 1 |
| Xu, J | 1 |
| Dydak, U | 1 |
| Harezlak, J | 1 |
| Nixon, J | 1 |
| Dzemidzic, M | 1 |
| Gunn, AD | 1 |
| Karne, HS | 1 |
| Anand, A | 1 |
| Elmorsy, E | 1 |
| Shahda, M | 1 |
| Mahmoud, el-HM | 1 |
| Rakha, SA | 1 |
| Shoaib, M | 1 |
| Soeiro-de-Souza, MG | 1 |
| Pastorello, BF | 1 |
| Leite, Cda C | 1 |
| Henning, A | 1 |
| Moreno, RA | 1 |
| Garcia Otaduy, MC | 1 |
| Regenold, WT | 1 |
| Phatak, P | 1 |
| Marano, CM | 1 |
| Sassan, A | 1 |
| Conley, RR | 1 |
| Kling, MA | 1 |
| LOWENBACH, H | 1 |
| GREENHILL, MH | 1 |
| Brady, RO | 1 |
| Cooper, A | 1 |
| Jensen, JE | 1 |
| Tandon, N | 1 |
| Cohen, B | 1 |
| Renshaw, P | 1 |
| Keshavan, M | 1 |
| ALTSCHULE, MD | 2 |
| HENNEMAN, DH | 1 |
| HOLLIDAY, P | 1 |
| GONCZ, RM | 1 |
| PERRIN, GM | 1 |
| HOLLIDAY, PD | 1 |
| Friedman, SD | 1 |
| Dager, SR | 1 |
| Parow, A | 1 |
| Hirashima, F | 1 |
| Demopulos, C | 1 |
| Stoll, AL | 1 |
| Lyoo, IK | 2 |
| Dunner, DL | 1 |
| Renshaw, PF | 2 |
| Fonseca, CP | 1 |
| Jones, JG | 1 |
| Carvalho, RA | 1 |
| Jeffrey, FM | 1 |
| Montezinho, LP | 1 |
| Geraldes, CF | 1 |
| Castro, MM | 1 |
| Kim, DJ | 1 |
| Yoon, SJ | 1 |
| Choi, T | 1 |
| Lee, B | 1 |
| Kim, JE | 1 |
| Lee, JS | 1 |
| Petty, F | 1 |
| Sherman, AD | 1 |
| Domino, EF | 1 |
| Sharp, RR | 1 |
| Lipper, S | 1 |
| Ballast, CL | 1 |
| Delidow, B | 1 |
| Bronzo, MR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Genetic Association Study Between GAD1 and Reelin Polymorphisms and GABA/Glutamate MRS in Bipolar Disorder Type 1 and Healthy Controls: SPECGENE PROJECT[NCT01237158] | 140 participants (Anticipated) | Observational | 2010-10-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for lactic acid and Bipolar Disorder
| Article | Year |
|---|---|
Brain lactate and pH in schizophrenia and bipolar disorder: a systematic review of findings from magnetic resonance studies.
Topics: Bipolar Disorder; Brain; Humans; Hydrogen-Ion Concentration; Lactic Acid; Schizophrenia | 2018 |
Lactate in bipolar disorder: A systematic review and meta-analysis.
Topics: Bipolar Disorder; Brain; Humans; Lactic Acid; Mitochondrial Diseases | 2018 |
Metabolomics in patients with psychosis: A systematic review.
Topics: 3-Hydroxybutyric Acid; Aspartic Acid; Biomarkers; Bipolar Disorder; Creatine; Female; Glutamic Acid; | 2018 |
1 trial available for lactic acid and Bipolar Disorder
| Article | Year |
|---|---|
Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder.
Topics: Adult; Analysis of Variance; Antimanic Agents; Bipolar Disorder; Brain; Brain Chemistry; Brain Mappi | 2004 |
13 other studies available for lactic acid and Bipolar Disorder
| Article | Year |
|---|---|
Magnetic resonance spectroscopy imaging of lactate in patients with bipolar disorder.
Topics: Adolescent; Adult; Analysis of Variance; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Female; | 2013 |
Neurochemical abnormalities in unmedicated bipolar depression and mania: a 2D 1H MRS investigation.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Brain; Creatine; Female; Glutamic Acid; Humans; Image Proces | 2013 |
Blood lactate levels as a biomarker of antipsychotic side effects in patients with schizophrenia.
Topics: Adult; Antipsychotic Agents; Biomarkers; Bipolar Disorder; Case-Control Studies; Dyskinesia, Drug-In | 2016 |
Dorsal Anterior Cingulate Lactate and Glutathione Levels in Euthymic Bipolar I Disorder: 1H-MRS Study.
Topics: Adolescent; Adult; Bipolar Disorder; Case-Control Studies; Female; Glutathione; Gyrus Cinguli; Human | 2016 |
Elevated cerebrospinal fluid lactate concentrations in patients with bipolar disorder and schizophrenia: implications for the mitochondrial dysfunction hypothesis.
Topics: Adult; Biomarkers; Bipolar Disorder; Blood Glucose; Case-Control Studies; Female; Glucose; Humans; L | 2009 |
The effect of oral administration of lactic acid upon the clinical course of depressive states.
Topics: Administration, Oral; Bipolar Disorder; Depression; Depressive Disorder; Humans; Lactic Acid; Mental | 1947 |
A longitudinal pilot proton MRS investigation of the manic and euthymic states of bipolar disorder.
Topics: Adult; Affect; Bipolar Disorder; Brain; Energy Metabolism; Female; Gyrus Cinguli; Humans; Image Proc | 2012 |
Carbohydrate metabolism in brain disease. VI. Lactate metabolism after infusion of sodium d-lactate in manic-depressive and schizophrenic psychoses.
Topics: Bipolar Disorder; Brain Diseases; Carbohydrate Metabolism; Humans; Lactic Acid; Mental Disorders; Ps | 1956 |
Carbohydrate metabolism in brain disease. XIII. Effect of lactate infusion on blood keto-acid concentrations in schizophremic and manic-depressive psychoses.
Topics: Bipolar Disorder; Brain Diseases; Carbohydrate Metabolism; Humans; Keto Acids; Lactates; Lactic Acid | 1960 |
Tricarboxylic acid cycle inhibition by Li+ in the human neuroblastoma SH-SY5Y cell line: a 13C NMR isotopomer analysis.
Topics: Acetyl Coenzyme A; Antimanic Agents; Bipolar Disorder; Brain; Brain Chemistry; Carbon Isotopes; Cell | 2005 |
Clinical response of quetiapine in rapid cycling manic bipolar patients and lactate level changes in proton magnetic resonance spectroscopy.
Topics: Adult; Analysis of Variance; Antipsychotic Agents; Bipolar Disorder; Dibenzothiazepines; Female; Hum | 2007 |
A pharmacologically pertinent animal model of mania.
Topics: Affective Disorders, Psychotic; Animals; Bipolar Disorder; Disease Models, Animal; Electroshock; Hum | 1981 |
NMR chemistry analysis of red blood cell constituents in normal subjects and lithium-treated psychiatric patients.
Topics: Bipolar Disorder; Choline; Erythrocytes; Female; Glycine; Humans; Lactates; Lactic Acid; Lithium; Ma | 1985 |