lactic acid has been researched along with BH4 Deficiency in 6 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It has been suggested that the hyperphenylalaninaemia in patients with PKU reduces complex I (NADH:ubiquinone reductase) activity of the mitochondrial respiratory chain (MRC) and/or biosynthesis of coenzyme Q(10) (CoQ(10)), which acts as an electron carrier in the MRC, leading to impaired energy metabolism in the brain of patients with PKU and hence the neurological pathology." | 1.35 | Assessment of mitochondrial respiratory chain function in hyperphenylalaninaemia. ( Hargreaves, I; Kyprianou, N; Lee, P; Murphy, E, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kyprianou, N | 1 |
| Murphy, E | 1 |
| Lee, P | 1 |
| Hargreaves, I | 1 |
| Zhang, D | 1 |
| Li, W | 1 |
| Zhang, J | 1 |
| Tang, W | 1 |
| Qian, C | 1 |
| Feng, M | 1 |
| Chu, Q | 1 |
| Ye, J | 1 |
| PRESCOTT, BA | 1 |
| BOREK, E | 1 |
| Bal, D | 1 |
| Kraska-Dziadecka, A | 1 |
| Gradowska, W | 1 |
| Gryff-Keller, A | 1 |
| Mönch, E | 1 |
| Herrmann, ME | 1 |
| Brösicke, H | 1 |
| Schöffer, A | 1 |
| Keller, M | 1 |
| Kolodny, EH | 1 |
| Yatziv, S | 1 |
6 other studies available for lactic acid and BH4 Deficiency
| Article | Year |
|---|---|
Assessment of mitochondrial respiratory chain function in hyperphenylalaninaemia.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Cell Line, Tumor; Cells, Cultured; Culture Media; Elect | 2009 |
Study on urinary metabolic profile of phenylketonuria by micellar electrokinetic capillary chromatography with dual electrochemical detection--potential clinical application in fast diagnosis of phenylketonuria.
Topics: Chromatography, Micellar Electrokinetic Capillary; Electrochemical Techniques; Humans; Hydrogen-Ion | 2011 |
Studies on oligophrenia phenylpyruvica; microbiological determination of L- and D-phenylalanine and of phenyl lactic acid.
Topics: Acids; Body Fluids; Intellectual Disability; Lactic Acid; Phenylalanine; Phenylketonurias; Urine | 1949 |
Investigation of a wide spectrum of inherited metabolic disorders by 13C NMR spectroscopy.
Topics: Biomarkers; Canavan Disease; Glutarates; Hemiterpenes; Humans; Lactic Acid; Magnetic Resonance Spect | 2008 |
Utilisation of amino acid mixtures in adolescents with phenylketonuria.
Topics: Adolescent; Adult; Amino Acids; Arginine; Blood Glucose; Diet, Protein-Restricted; Dietary Proteins; | 1996 |
Laboratory approaches for inherited neurometabolic diseases.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Galactosemias; Homocystinuria; Humans; Lactates; Lact | 1985 |