lactic acid has been researched along with B16 Melanoma in 30 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Among the types of vehicles for cancer vaccines, nanoparticles (NPs) are easier to produce with better scalability." | 1.46 | Nanotechnology-Based Cancer Vaccine. ( Alshamsan, A, 2017) |
| "Melanoma is a largely incurable skin malignancy owing to the underlying molecular and metabolic heterogeneity confounded by the development of resistance." | 1.42 | Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression. ( Bhat, MK; Chaube, B; Malvi, P; Meena, AS; Mohammad, N; Singh, SV, 2015) |
| "In mice injected with B16 melanoma cells, the sustained IL-1Ra delivery from biodegradable microspheres inhibited tumor growth and significantly prolonged mice survival." | 1.34 | Sustained delivery of IL-1 Ra from biodegradable microspheres reduces the number of murine B16 melanoma lung metastases. ( Apte, RN; Cohen, S; Dinarello, CA; Lavi, G; Voronov, E, 2007) |
| "C57BL6 mice with established B16 melanomas underwent a single intralesional injection of IL-12, TNF-alpha or GM-CSF PLAM, alone or in combination." | 1.33 | Neoadjuvant intratumoral cytokine-loaded microspheres are superior to postoperative autologous cellular vaccines in generating systemic anti-tumor immunity. ( Arora, A; Chang, AE; Mathiowitz, E; Reineke, J; Sabel, MS; Su, G, 2006) |
| "Treatment with lactic acid, a known inhibitor of tyrosinase gene expression, also led to the down-regulation of gamma-GT mRNA and activity." | 1.31 | Type I gamma-GT mRNA is expressed in B16 melanoma and levels correlate with pigmentation. ( Chaubal, VA; Mojamdar, MV; Nair, SS, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.67) | 18.2507 |
| 2000's | 8 (26.67) | 29.6817 |
| 2010's | 18 (60.00) | 24.3611 |
| 2020's | 2 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Wagner, M | 1 |
| Ealey, KN | 1 |
| Tetsu, H | 1 |
| Kiniwa, T | 1 |
| Motomura, Y | 1 |
| Moro, K | 1 |
| Koyasu, S | 1 |
| Wang, Z | 1 |
| Xu, F | 1 |
| Hu, J | 1 |
| Zhang, H | 2 |
| Cui, L | 1 |
| Lu, W | 1 |
| He, W | 1 |
| Wang, X | 1 |
| Li, M | 1 |
| Xiong, W | 1 |
| Xie, C | 1 |
| Liu, Y | 1 |
| Zhou, P | 1 |
| Liu, J | 1 |
| Huang, P | 1 |
| Qin, XF | 1 |
| Xia, X | 1 |
| Gaonkar, RH | 1 |
| Ganguly, S | 3 |
| Dewanjee, S | 1 |
| Sinha, S | 2 |
| Gupta, A | 2 |
| Chattopadhyay, D | 1 |
| Chatterjee Debnath, M | 1 |
| Matsuo, T | 2 |
| Sadzuka, Y | 2 |
| Farias, CLA | 1 |
| Martinez, GR | 1 |
| Cadena, SMSC | 1 |
| Mercê, ALR | 1 |
| de Oliveira Petkowicz, CL | 1 |
| Noleto, GR | 1 |
| Daishaku, S | 1 |
| Shinto, H | 1 |
| Hirata, T | 1 |
| Fukasawa, T | 1 |
| Fujii, S | 1 |
| Maeda, H | 1 |
| Okada, M | 1 |
| Nakamura, Y | 1 |
| Furuzono, T | 1 |
| Colegio, OR | 1 |
| Chu, NQ | 1 |
| Szabo, AL | 1 |
| Chu, T | 1 |
| Rhebergen, AM | 1 |
| Jairam, V | 1 |
| Cyrus, N | 1 |
| Brokowski, CE | 1 |
| Eisenbarth, SC | 1 |
| Phillips, GM | 1 |
| Cline, GW | 1 |
| Phillips, AJ | 1 |
| Medzhitov, R | 1 |
| Mariano, RN | 1 |
| Alberti, D | 1 |
| Cutrin, JC | 1 |
| Geninatti Crich, S | 1 |
| Aime, S | 1 |
| Feng, T | 1 |
| Tian, H | 1 |
| Xu, C | 1 |
| Lin, L | 1 |
| Xie, Z | 1 |
| Lam, MH | 1 |
| Liang, H | 1 |
| Chen, X | 1 |
| Büll, C | 1 |
| Boltje, TJ | 1 |
| van Dinther, EA | 1 |
| Peters, T | 1 |
| de Graaf, AM | 1 |
| Leusen, JH | 1 |
| Kreutz, M | 1 |
| Figdor, CG | 1 |
| den Brok, MH | 1 |
| Adema, GJ | 1 |
| Bruno, C | 1 |
| Waeckerle-Men, Y | 1 |
| Håkerud, M | 1 |
| Kündig, TM | 1 |
| Gander, B | 1 |
| Johansen, P | 1 |
| Heo, MB | 1 |
| Kim, SY | 1 |
| Yun, WS | 1 |
| Lim, YT | 1 |
| Chaube, B | 1 |
| Malvi, P | 1 |
| Singh, SV | 1 |
| Mohammad, N | 1 |
| Meena, AS | 1 |
| Bhat, MK | 1 |
| Baishya, R | 1 |
| Nayak, DK | 1 |
| Kumar, D | 1 |
| Debnath, MC | 1 |
| Alshamsan, A | 3 |
| Zhao, Y | 1 |
| Tang, S | 1 |
| Guo, J | 1 |
| Alahdal, M | 1 |
| Cao, S | 1 |
| Yang, Z | 1 |
| Zhang, F | 1 |
| Shen, Y | 1 |
| Sun, M | 1 |
| Mo, R | 1 |
| Zong, L | 1 |
| Jin, L | 1 |
| Hamdy, S | 4 |
| Molavi, O | 3 |
| Ma, Z | 2 |
| Haddadi, A | 2 |
| Gobti, Z | 1 |
| Elhasi, S | 1 |
| Samuel, J | 4 |
| Lavasanifar, A | 4 |
| Goforth, R | 1 |
| Salem, AK | 1 |
| Zhu, X | 1 |
| Miles, S | 1 |
| Zhang, XQ | 1 |
| Lee, JH | 1 |
| Sandler, AD | 1 |
| Mahmud, A | 1 |
| Hung, RW | 1 |
| Lai, R | 1 |
| El-Kadi, AO | 1 |
| Uludağ, H | 1 |
| Renette, T | 1 |
| Librizzi, D | 1 |
| Endres, T | 1 |
| Merkel, O | 1 |
| Beck-Broichsitter, M | 1 |
| Bege, N | 1 |
| Petersen, H | 1 |
| Curdy, C | 1 |
| Kissel, T | 1 |
| Chaubal, VA | 1 |
| Nair, SS | 1 |
| Mojamdar, MV | 1 |
| Takenaga, M | 1 |
| Tamamura, H | 1 |
| Hiramatsu, K | 1 |
| Nakamura, N | 1 |
| Yamaguchi, Y | 1 |
| Kitagawa, A | 1 |
| Kawai, S | 1 |
| Nakashima, H | 1 |
| Fujii, N | 1 |
| Igarashi, R | 1 |
| Arora, A | 1 |
| Su, G | 1 |
| Mathiowitz, E | 1 |
| Reineke, J | 1 |
| Chang, AE | 1 |
| Sabel, MS | 1 |
| Lavi, G | 1 |
| Voronov, E | 1 |
| Dinarello, CA | 1 |
| Apte, RN | 1 |
| Cohen, S | 1 |
| Shime, H | 1 |
| Yabu, M | 1 |
| Akazawa, T | 1 |
| Kodama, K | 1 |
| Matsumoto, M | 1 |
| Seya, T | 1 |
| Inoue, N | 1 |
| Kroeger, M | 1 |
| Walenta, S | 1 |
| Rofstad, EK | 1 |
| Mueller-Klieser, W | 1 |
| Hagiwara, A | 1 |
| Sakakura, C | 1 |
| Shirasu, M | 1 |
| Yamasaki, J | 1 |
| Togawa, T | 1 |
| Takahashi, T | 1 |
| Muranishi, S | 1 |
| Hyon, S | 1 |
| Ikada, Y | 1 |
30 other studies available for lactic acid and B16 Melanoma
| Article | Year |
|---|---|
Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s.
Topics: Animals; Cell Proliferation; Cell Survival; Eosinophils; Female; Humans; Immunity, Innate; Interleuk | 2020 |
Modulation of lactate-lysosome axis in dendritic cells by clotrimazole potentiates antitumor immunity.
Topics: Animals; Antineoplastic Agents; Basic-Leucine Zipper Transcription Factors; Cell Line, Tumor; Clotri | 2021 |
Garcinol loaded vitamin E TPGS emulsified PLGA nanoparticles: preparation, physicochemical characterization, in vitro and in vivo studies.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Chemical Phenomena; Drug | 2017 |
Extracellular acidification by lactic acid suppresses glucose deprivation-induced cell death and autophagy in B16 melanoma cells.
Topics: Animals; Apoptosis; Autophagy; Cell Line, Tumor; Extracellular Fluid; Glucose; Hydrogen-Ion Concentr | 2018 |
Cytotoxicity of xyloglucan from Copaifera langsdorffii and its complex with oxovanadium (IV/V) on B16F10 cells.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Fabaceae; Glucans; Lactic Acid; M | 2019 |
Lactic Acid Promotes Cell Survival by Blocking Autophagy of B16F10 Mouse Melanoma Cells under Glucose Deprivation and Hypoxic Conditions.
Topics: Animals; Autophagy; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Glucose; Lactic Acid; Melanoma, E | 2019 |
Effect of interfacial serum proteins on melanoma cell adhesion to biodegradable poly(l-lactic acid) microspheres coated with hydroxyapatite.
Topics: Animals; Blood Proteins; Cattle; Cell Adhesion; Cell Line, Tumor; Colloids; Durapatite; Lactic Acid; | 2013 |
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.
Topics: Animals; Arginase; Carcinoma, Lewis Lung; Cell Communication; Cell Division; Culture Media, Conditio | 2014 |
Design of PLGA based nanoparticles for imaging guided applications.
Topics: Animals; Biocompatible Materials; Contrast Media; Drug Carriers; Drug Design; Lactic Acid; Magnetic | 2014 |
Synergistic co-delivery of doxorubicin and paclitaxel by porous PLGA microspheres for pulmonary inhalation treatment.
Topics: Administration, Inhalation; Animals; Antineoplastic Agents; Doxorubicin; Drug Carriers; Drug Deliver | 2014 |
Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread.
Topics: Animals; Antibodies; Biomimetic Materials; Drug Carriers; Female; Lactic Acid; Lung Neoplasms; Melan | 2015 |
Photosensitizer and Light Pave the Way for Cytosolic Targeting and Generation of Cytosolic CD8 T Cells Using PLGA Vaccine Particles.
Topics: Animals; Antibodies, Neoplasm; Antigens, Neoplasm; Cancer Vaccines; Cytosol; Dendritic Cells; Drug C | 2015 |
Sequential delivery of an anticancer drug and combined immunomodulatory nanoparticles for efficient chemoimmunotherapy.
Topics: Animals; Antigens, Neoplasm; Antineoplastic Agents; Bone Marrow Cells; Combined Modality Therapy; Cy | 2015 |
Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Lin | 2015 |
Ursolic Acid Loaded PLGA Nanoparticles: in vitro and in vivo Evaluation to Explore Tumor Targeting Ability on B16F10 Melanoma Cell Lines.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Drug Car | 2016 |
Nanotechnology-Based Cancer Vaccine.
Topics: Animals; Cancer Vaccines; Dendritic Cells; Disease Models, Animal; Humans; Immunotherapy; Lactic Aci | 2017 |
Targeted delivery of doxorubicin by nano-loaded mesenchymal stem cells for lung melanoma metastases therapy.
Topics: Animals; Antineoplastic Agents; Cell Death; Cell Survival; Doxorubicin; Drug Delivery Systems; Lacti | 2017 |
Co-delivery of cancer-associated antigen and Toll-like receptor 4 ligand in PLGA nanoparticles induces potent CD8+ T cell-mediated anti-tumor immunity.
Topics: Animals; Antigens, Neoplasm; Cancer Vaccines; CD8-Positive T-Lymphocytes; Cells, Cultured; Cytotoxic | 2008 |
Immune stimulatory antigen loaded particles combined with depletion of regulatory T-cells induce potent tumor specific immunity in a mouse model of melanoma.
Topics: Animals; Antigen Presentation; Antigen-Presenting Cells; Antigens, Neoplasm; Cancer Vaccines; Enzyme | 2009 |
Immunomodulatory and anticancer effects of intra-tumoral co-delivery of synthetic lipid A adjuvant and STAT3 inhibitor, JSI-124.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Combined Chemotherapy Protocols; Dendritic Cells; Dr | 2009 |
Development of a poly(d,l-lactic-co-glycolic acid) nanoparticle formulation of STAT3 inhibitor JSI-124: implication for cancer immunotherapy.
Topics: Animals; Cell Line, Tumor; Cells, Cultured; Dendritic Cells; Flow Cytometry; Immunotherapy; Lactic A | 2010 |
STAT3 silencing in dendritic cells by siRNA polyplexes encapsulated in PLGA nanoparticles for the modulation of anticancer immune response.
Topics: Animals; Base Sequence; Biological Transport, Active; Cell Line, Tumor; Cells, Cultured; Dendritic C | 2010 |
Poly(ethylene carbonate) nanoparticles as carrier system for chemotherapy showing prolonged in vivo circulation and anti-tumor efficacy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carbon Radioisotopes; Drug Carriers; Drug Compounding; D | 2012 |
Type I gamma-GT mRNA is expressed in B16 melanoma and levels correlate with pigmentation.
Topics: Animals; Antigens, Neoplasm; Base Sequence; gamma-Glutamyltransferase; Gene Expression Regulation, E | 2002 |
A single treatment with microcapsules containing a CXCR4 antagonist suppresses pulmonary metastasis of murine melanoma.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Delayed-Action Preparations; Dose-R | 2004 |
Neoadjuvant intratumoral cytokine-loaded microspheres are superior to postoperative autologous cellular vaccines in generating systemic anti-tumor immunity.
Topics: Animals; Cancer Vaccines; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Immunotherapy, A | 2006 |
Sustained delivery of IL-1 Ra from biodegradable microspheres reduces the number of murine B16 melanoma lung metastases.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmaceutical; Del | 2007 |
Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway.
Topics: Animals; Cell Line, Tumor; Culture Media, Conditioned; Gene Expression Regulation, Neoplastic; Granu | 2008 |
Growth rates or radiobiological hypoxia are not correlated with local metabolite content in human melanoma xenografts with similar vascular network.
Topics: Adenosine Triphosphate; Animals; Cell Hypoxia; Female; Glucose; Humans; Lactates; Lactic Acid; Melan | 1995 |
Therapeutic effects of 5-fluorouracil microspheres on peritoneal carcinomatosis induced by Colon 26 or B-16 melanoma in mice.
Topics: Animals; Biocompatible Materials; Colonic Neoplasms; Fluorouracil; Injections, Intraperitoneal; Lact | 1998 |