lactic acid has been researched along with Ataxia in 14 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyruvate dehydrogenase complex (PDHC) activity was measured in cultured fibroblasts from 12 patients with Friedreich's ataxia (FA), and in 1 patient with lactic acidosis and ataxia." | 7.66 | Pyruvate-dehydrogenase complex in ataxic patients: enzyme deficiency in ataxic encephalopathy plus lactic acidosis and normal activity in Friedreich ataxia. ( Bottacchi, E; Cardace, G; Di Donato, S; Giovanardi-Rossi, P; Moschen, G; Uziel, G, 1982) |
| " One in particular, D-lactic acidosis, causes a neurologic syndrome characterized by altered mental status, slurred speech, and ataxia, typically after a large carbohydrate meal." | 3.81 | A 3-year-old boy with ataxia. ( Fichadia, U; Park, B; Shah, A, 2015) |
| "Lactic acidosis (DAC) occurs as a complication of short-bowel syndrome in humans and in a variety of other gastrointestinal disorders in monogastrics and ruminants." | 3.74 | D-Lactic acid-induced neurotoxicity in a calf model. ( Abeysekara, S; Isak, U; Naylor, JM; Wassef, AW; Zello, GA, 2007) |
| "Pyruvate dehydrogenase complex (PDHC) activity was measured in cultured fibroblasts from 12 patients with Friedreich's ataxia (FA), and in 1 patient with lactic acidosis and ataxia." | 3.66 | Pyruvate-dehydrogenase complex in ataxic patients: enzyme deficiency in ataxic encephalopathy plus lactic acidosis and normal activity in Friedreich ataxia. ( Bottacchi, E; Cardace, G; Di Donato, S; Giovanardi-Rossi, P; Moschen, G; Uziel, G, 1982) |
| "Inherited ataxias are a group of heterogeneous disorders in children or adults but their genetic definition remains still undetermined in almost half of the patients." | 1.43 | Cerebellar ataxia and severe muscle CoQ10 deficiency in a patient with a novel mutation in ADCK3. ( Barca, E; DiMauro, S; Granata, F; Marino, S; Montagnese, F; Musumeci, O; Nunnari, D; Peverelli, L; Quinzii, CM; Toscano, A, 2016) |
| "Both patients had PDH deficiency caused by a new mutation (G585C) in the PDHA1 gene, which is predicted to replace a highly conserved glycine at codon 195 by alanine." | 1.35 | Pyruvate dehydrogenase deficiency presenting as intermittent isolated acute ataxia. ( Debray, FG; Gagne, R; Laframboise, R; Lambert, M; MacKay, N; Maranda, B; Mitchell, GA; Robinson, BH, 2008) |
| " Therefore, dosing can be changed from the conventional twice a day to once every 2 weeks." | 1.32 | Microspheres containing insulin-like growth factor I for treatment of chronic neurodegeneration. ( Carrascosa, C; Carro, E; Espejo, L; Lopez-Lopez, C; Torrado, JJ; Torrado, S; Torres-Aleman, I, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (21.43) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Wongkittichote, P | 1 |
| Magistrati, M | 1 |
| Shimony, JS | 1 |
| Smyser, CD | 1 |
| Fatemi, SA | 1 |
| Fine, AS | 1 |
| Bellacchio, E | 1 |
| Dallabona, C | 1 |
| Shinawi, M | 1 |
| Park, B | 1 |
| Fichadia, U | 1 |
| Shah, A | 1 |
| Barca, E | 1 |
| Musumeci, O | 1 |
| Montagnese, F | 1 |
| Marino, S | 1 |
| Granata, F | 1 |
| Nunnari, D | 1 |
| Peverelli, L | 1 |
| DiMauro, S | 2 |
| Quinzii, CM | 1 |
| Toscano, A | 1 |
| James, PD | 1 |
| Black, D | 1 |
| Kuper, A | 1 |
| Saibil, F | 1 |
| Szklarczyk, R | 1 |
| Wanschers, BF | 1 |
| Nijtmans, LG | 1 |
| Rodenburg, RJ | 1 |
| Zschocke, J | 1 |
| Dikow, N | 1 |
| van den Brand, MA | 1 |
| Hendriks-Franssen, MG | 1 |
| Gilissen, C | 1 |
| Veltman, JA | 1 |
| Nooteboom, M | 1 |
| Koopman, WJ | 1 |
| Willems, PH | 1 |
| Smeitink, JA | 1 |
| Huynen, MA | 1 |
| van den Heuvel, LP | 1 |
| Overweg-Plandsoen, WC | 1 |
| Groener, JE | 1 |
| Wang, D | 1 |
| Onkenhout, W | 1 |
| Brouwer, OF | 1 |
| Bakker, HD | 1 |
| De Vivo, DC | 1 |
| Carrascosa, C | 1 |
| Torres-Aleman, I | 1 |
| Lopez-Lopez, C | 1 |
| Carro, E | 1 |
| Espejo, L | 1 |
| Torrado, S | 1 |
| Torrado, JJ | 1 |
| Abeysekara, S | 1 |
| Naylor, JM | 1 |
| Wassef, AW | 1 |
| Isak, U | 1 |
| Zello, GA | 1 |
| Ferraris, S | 1 |
| Clark, S | 1 |
| Garelli, E | 1 |
| Davidzon, G | 1 |
| Moore, SA | 1 |
| Kardon, RH | 1 |
| Bienstock, RJ | 1 |
| Longley, MJ | 1 |
| Mancuso, M | 1 |
| Gutiérrez Ríos, P | 1 |
| Hirano, M | 1 |
| Copeland, WC | 1 |
| Debray, FG | 1 |
| Lambert, M | 1 |
| Gagne, R | 1 |
| Maranda, B | 1 |
| Laframboise, R | 1 |
| MacKay, N | 1 |
| Robinson, BH | 1 |
| Mitchell, GA | 1 |
| Livingstone, IR | 1 |
| Gardner-Medwin, D | 1 |
| Pennington, RJ | 1 |
| Uziel, G | 1 |
| Bottacchi, E | 1 |
| Moschen, G | 1 |
| Giovanardi-Rossi, P | 1 |
| Cardace, G | 1 |
| Di Donato, S | 1 |
| Tedeschi, G | 1 |
| Schiffmann, R | 1 |
| Barton, NW | 1 |
| Shih, HH | 1 |
| Gospe, SM | 1 |
| Brady, RO | 1 |
| Alger, JR | 1 |
| Di Chiro, G | 1 |
| Al-Mateen, M | 1 |
| Philippart, M | 1 |
| Shields, WD | 1 |
14 other studies available for lactic acid and Ataxia
| Article | Year |
|---|---|
Functional analysis of missense DARS2 variants in siblings with leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation.
Topics: Adolescent; Adult; Aspartate-tRNA Ligase; Ataxia; Brain Stem; Disease Progression; Humans; Lactic Ac | 2022 |
A 3-year-old boy with ataxia.
Topics: Acidosis, Lactic; Ataxia; Child, Preschool; Diagnosis, Differential; Humans; Lactic Acid; Male; Shor | 2015 |
Cerebellar ataxia and severe muscle CoQ10 deficiency in a patient with a novel mutation in ADCK3.
Topics: Ataxia; Cerebellar Ataxia; Codon, Nonsense; Delayed Diagnosis; Electron Transport Chain Complex Prot | 2016 |
D-lactic acidosis and ataxia in a man with Crohn disease.
Topics: Acidosis, Lactic; Anti-Inflammatory Agents; Antidiarrheals; Ataxia; Crohn Disease; Diagnosis, Differ | 2010 |
A mutation in the FAM36A gene, the human ortholog of COX20, impairs cytochrome c oxidase assembly and is associated with ataxia and muscle hypotonia.
Topics: Abnormalities, Multiple; Amino Acid Sequence; Animals; Ataxia; Base Sequence; Cells, Cultured; Child | 2013 |
GLUT-1 deficiency without epilepsy--an exceptional case.
Topics: Ataxia; Blood Glucose; Carbohydrate Metabolism, Inborn Errors; Child; DNA; DNA Mutational Analysis; | 2003 |
Microspheres containing insulin-like growth factor I for treatment of chronic neurodegeneration.
Topics: Animals; Ataxia; Coated Materials, Biocompatible; Delayed-Action Preparations; Female; Insulin-Like | 2004 |
D-Lactic acid-induced neurotoxicity in a calf model.
Topics: Acidosis, Lactic; Animals; Ataxia; Cattle; Hydrochloric Acid; Lactic Acid; Models, Animal; Nervous S | 2007 |
Progressive external ophthalmoplegia and vision and hearing loss in a patient with mutations in POLG2 and OPA1.
Topics: Adult; Anemia, Macrocytic; Ataxia; Biopsy; Blotting, Southern; Cytochromes c; DNA Polymerase gamma; | 2008 |
Pyruvate dehydrogenase deficiency presenting as intermittent isolated acute ataxia.
Topics: Ataxia; Basal Ganglia Diseases; Binding Sites; Brain Diseases, Metabolic; Child; Child, Preschool; D | 2008 |
Familial intermittent ataxia with possible X-linked recessive inheritance. Two patients with abnormal pyruvate metabolism and a response to acetazolamide.
Topics: Acetazolamide; Adolescent; Adult; Ataxia; Female; Genes, Recessive; Humans; Lactates; Lactic Acid; M | 1984 |
Pyruvate-dehydrogenase complex in ataxic patients: enzyme deficiency in ataxic encephalopathy plus lactic acidosis and normal activity in Friedreich ataxia.
Topics: Acidosis; Adolescent; Ataxia; Brain Diseases; Fibroblasts; Friedreich Ataxia; Humans; Lactates; Lact | 1982 |
Proton magnetic resonance spectroscopic imaging in childhood ataxia with diffuse central nervous system hypomyelination.
Topics: Aspartic Acid; Ataxia; Brain; Brain Diseases; Child, Preschool; Choline; Creatine; Female; Gaucher D | 1995 |
Rett syndrome. A commonly overlooked progressive encephalopathy in girls.
Topics: Adolescent; Adult; Ataxia; Basal Ganglia Diseases; Brain Diseases; Child; Child, Preschool; Dementia | 1986 |