lactic acid and Asystole studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Research Excerpts

Excerpt	Relevance	Reference
"When compared to cocaine exposure alone, CE exposure in ED patients with acute drug overdose was significantly associated with higher occurrence of cardiac arrest, higher mean lactate concentrations, and lower occurrence of myocardial injury."	8.31	Cocaethylene cardiotoxicity in emergency department patients with acute drug overdose. ( Manini, AF; Manoochehri, O; Richardson, LD; Shastry, S, 2023)
"The results of our study showed that rats that had been administered oral carvedilol for several days were more resistant to CA induced by airway obstruction, and when CA did occur, were more likely to be resuscitated."	7.76	The effects of carvedilol administration on cardiopulmonary resuscitation in a rat model of cardiac arrest induced by airway obstruction. ( Kurita, A; Taniguchi, T; Yamamoto, K, 2010)
"We report 4 cases of lactic acidosis in diabetic patients usually treated with metformin."	7.72	[Metformin-associated lactic acidosis remains a serious complication of metformin therapy]. ( Giunti, C; Grimaud, D; Ichai, C; Levraut, J; Orban, JC, 2003)
"Lactic acidosis is seen frequently after severe anoxia and circulatory failure."	7.67	Effect of dichloroacetate in the treatment of anoxic lactic acidosis in dogs. ( Caputo, G; Delgado Paredes, C; Egler, J; Fleisher, G; Schaible, D; Sheikh, A; Swedlow, D, 1986)
"Levels of brain creatine phosphokinase (CPK), glutamic oxalic transaminase, lactate dehydrogenase, and lactate in lumbar cerebrospinal fluid (CSF) were analyzed as an adjunctive study in a randomized clinical trial evaluating the effects of thiopental loading intravenously in comatose survivors of cardiac arrest."	5.07	The use of cytosolic enzyme increase in cerebrospinal fluid of patients resuscitated after cardiac arrest. Brain Resuscitation Clinical Trial I Study Group. ( Abramson, N; Fodstad, DT; Mullie, A; Safar, P; Vaagenes, P, 1994)
"When compared to cocaine exposure alone, CE exposure in ED patients with acute drug overdose was significantly associated with higher occurrence of cardiac arrest, higher mean lactate concentrations, and lower occurrence of myocardial injury."	4.31	Cocaethylene cardiotoxicity in emergency department patients with acute drug overdose. ( Manini, AF; Manoochehri, O; Richardson, LD; Shastry, S, 2023)
" As for patients, inclusion criteria were: 1) age ≥18 years; 2) non-traumatic out-of-hospital cardiac arrest with return of spontaneous circulation; 3) lactic acid measured within one hour of return of circulation."	3.77	The association of lactate and vasopressor need for mortality prediction in survivors of cardiac arrest. ( Carney, E; Cocchi, MN; Donnino, MW; Farris, S; Howell, MD; Hunziker, S; Joyce, N; Miller, J; Salciccioli, J; Zimetbaum, P, 2011)
"The results of our study showed that rats that had been administered oral carvedilol for several days were more resistant to CA induced by airway obstruction, and when CA did occur, were more likely to be resuscitated."	3.76	The effects of carvedilol administration on cardiopulmonary resuscitation in a rat model of cardiac arrest induced by airway obstruction. ( Kurita, A; Taniguchi, T; Yamamoto, K, 2010)
"We report 4 cases of lactic acidosis in diabetic patients usually treated with metformin."	3.72	[Metformin-associated lactic acidosis remains a serious complication of metformin therapy]. ( Giunti, C; Grimaud, D; Ichai, C; Levraut, J; Orban, JC, 2003)
"Lactic acidosis is seen frequently after severe anoxia and circulatory failure."	3.67	Effect of dichloroacetate in the treatment of anoxic lactic acidosis in dogs. ( Caputo, G; Delgado Paredes, C; Egler, J; Fleisher, G; Schaible, D; Sheikh, A; Swedlow, D, 1986)
"Patients experienced in-hospital cardiac arrest between 2012 and 2015 were included in the predefined post hoc analyses."	3.11	Effect of Shenfu Injection () on Lactate and Lactate Clearance in Patients with Post-cardiac Arrest Syndrome: A Post Hoc Analysis of a Multicenter Randomized Controlled Trial. ( He, Y; Li, C; Wang, GX; Wang, YX; Zhang, Q, 2022)
"In total, 15 patients who experienced cardiac arrest outside the hospital setting and who could be reanimated were enrolled in this study."	2.90	Plasma Adenylate Levels are Elevated in Cardiopulmonary Arrest Patients and May Predict Mortality. ( Inoue, Y; Junger, WG; Kondo, Y; Ledderose, C; Li, L; Okamoto, K; Sueyoshi, K; Sumi, Y; Tanaka, H, 2019)
"Asystole as the initial arrest rhythm, administration of >4 adrenaline doses, and higher post-arrest blood lactate concentration were independently associated with lower 12-month survival; an adrenaline dosing interval of 3-<5 min and open chest compressions were independently associated with greater 12-month survival."	2.87	Paediatric in-hospital cardiac arrest: Factors associated with survival and neurobehavioural outcome one year later. ( Berger, J; Christensen, JR; Dean, JM; Holubkov, R; Meert, K; Moler, FW; Newth, CJL; Ofori-Amanfo, G; Slomine, BS; Telford, R, 2018)
"23 studies involving 6720 cardiac arrest (CA) patients were included."	2.58	Blood Lactate or Lactate Clearance: Which Is Robust to Predict the Neurological Outcomes after Cardiac Arrest? A Systematic Review and Meta-Analysis. ( Liu, CF; Liu, LJ; Zhang, Z; Zhou, BC; Zhu, JJ, 2018)
"In the multivariate Cox model analysis, cardiac arrest prior to ECMO initiation (adjusted HR 2."	1.91	Clinical outcome and risk factors for acute fulminant myocarditis supported by venoarterial extracorporeal membrane oxygenation: An analysis of nationwide CSECLS database in China. ( Chen, C; Du, Z; Guo, F; Hao, T; Hou, X; Huang, Y; Jiang, Y; Li, C; Liu, L; Liu, S; Pan, C; Qiu, H; Wu, C; Xie, H; Xie, J; Yang, Y, 2023)
"During pediatric cardiac arrest, contemporary guidelines recommend dosing epinephrine at regular intervals, including in patients requiring extracorporeal membrane oxygenation (ECMO)."	1.91	Epinephrine Dosing Use During Extracorporeal Cardiopulmonary Resuscitation: Single-Center Retrospective Cohort. ( Floh, AA; Goco, G; Guerguerian, AM; Haller, C; Honjo, O; Kucher, NM; Marquez, AM; Moga, MA; Todd, M; Vargas-Gutierrez, M, 2023)
"In a mouse model of cardiac arrest, 100 mg/kg NAM administered IV immediately after cardiopulmonary resuscitation resulted in 100% survival at 4 h as compared to 50% in the saline group."	1.91	Nicotinamide restores tissue NAD+ and improves survival in rodent models of cardiac arrest. ( Gasior, FM; Justice, CN; Lee, C; Li, J; Lin, S; O'Donnell, JM; Vanden Hoek, TL; Wang, H; Zhu, X, 2023)
"In a proof-of-concept porcine model of cardiac arrest, the integrated analysis system proved reliable in a challenging environment resembling a clinical setting; noise levels were found to be comparable with those seen in the lab and were not affected by major clinical interventions such as defibrillation of the heart."	1.56	Real-time neurochemical measurement of dynamic metabolic events during cardiac arrest and resuscitation in a porcine model. ( Boutelle, MG; Gowers, SAN; Jeyaprakash, S; Karlsson, M; Murray, DRK; Møller, K; Olsen, MH; Rogers, ML; Samper, IC; Smith, GK, 2020)
"Notably, despite the 5 min of cardiac arrest in the treated group, both the lactate and bicarbonate levels were maintained without significant variation."	1.56	Interventionist videothermometry: a new model of cardiac ischemia evaluation. ( Antunes, F; Cabral, PGA; Cadena, SMR; da Mota Costa, MR; da Silva, TOB; de Abreu Oliveira, AL; de Moura Vidal, LW; Dos Santos Junior, MB, 2020)
"Lactic acid levels were high immediately after ROSC in both groups, but were significantly lower in the 20 rpm group at 30 (3."	1.56	Effect of ventilation rate on recovery after cardiac arrest in a pediatric animal model. ( Arias, P; Domenech, B; Fernández, SN; Horcajo, D; López, J; López-Herce, J; Nocete, JP; Zamora, L, 2020)
"In 72 patients with cardiac arrest before venoarterial extracorporeal membrane oxygenation initiation, nonshockable rhythm, arterial lactate, and ischemic heart disease were identified as independent pre-venoarterial extracorporeal membrane oxygenation risk factors of 90-day mortality."	1.51	Cardiac Arrest Prior to Venoarterial Extracorporeal Membrane Oxygenation: Risk Factors for Mortality. ( Corbascio, M; Fux, T; Holm, M; van der Linden, J, 2019)
"For better care of postcardiac arrest patients, objective serial assessments of brain injury severity are needed."	1.48	Monitoring of Cerebral Metabolism in Postcardiac Arrest Patients: A Pilot Study. ( Chae, MK; Kang, SY; Lee, SE; Sim, MS, 2018)
"The number of cardiac arrests (CA) in the group of very elderly patients (≥ 90 years) is expected to increase markedly due to the world`s rapidly ageing population."	1.48	Long-term neurological outcomes in patients aged over 90 years who are admitted to the intensive care unit following cardiac arrest. ( Becker, S; Fuhrmann, V; Jarczak, D; Kluge, S; Müller, J; Roedl, K, 2018)
"We included consecutive adult cardiac arrest survivors treated with TTM between 2012 and 2015."	1.46	Neuromuscular blockade requirement is associated with good neurologic outcome in cardiac arrest survivors treated with targeted temperature management. ( Cho, YS; Jeung, KW; Jung, YH; Lee, BK; Lee, DH; Min, YI; Youn, CS, 2017)
"The rats underwent 5 min of untreated asphyxial cardiac arrest and were resuscitated by ECLS for 30 min."	1.46	Investigation of the pathophysiology of cardiopulmonary bypass using rodent extracorporeal life support model. ( Chang, RW; Chen, YS; Luo, CM; Wang, CH; Yu, HY, 2017)
"We utilized a porcine cardiac arrest model to compare early sequential hypothermia (ESH) with delayed hypothermia (DH) and no hypothermia (NH) to investigate the different effects on cerebral function after resuscitation."	1.46	Comparison of early sequential hypothermia and delayed hypothermia on neurological function after resuscitation in a swine model. ( Li, CS; Li, J; Li, JB; Li, ZH; Wu, JY; Yuan, W; Zhao, YZ, 2017)
"Using the adverse outcomes of cardiac arrest, ICU mortality, and ICU readmissions, a retrospective case-control study was performed using three demographic items (age, diabetes, and morbid obesity) and 24 EWD measured items, including vital signs, laboratory values, ventilator information, and other clinical information, to validate the EWD."	1.46	Validation of the Intensive Care Unit Early Warning Dashboard: Quality Improvement Utilizing a Retrospective Case-Control Evaluation. ( Davis, KL; Kavanaugh, MJ; Park, PJ; So, JD, 2017)
"Cardiac arrest is the major cause of sudden death in developed countries."	1.43	Outcome predictors in cardiopulmonary resuscitation facilitated by extracorporeal membrane oxygenation. ( Figulla, HR; Fritzenwanger, M; Fuernau, G; Janssen, K; Jung, C; Kaluza, M; Pfeifer, R; Poerner, TC; Thiele, H, 2016)
"Cerebral metabolic alterations during cardiac arrest, cardiopulmonary resuscitation (CPR) and extracorporeal cardiopulmonary life support (ECLS) are poorly explored."	1.43	Microdialysis Assessment of Cerebral Perfusion during Cardiac Arrest, Extracorporeal Life Support and Cardiopulmonary Resuscitation in Rats - A Pilot Trial. ( Ettl, F; Herkner, H; Högler, S; Hosmann, A; Janata, A; Laggner, AN; Magnet, IA; Scherer, T; Schober, A; Sterz, F; Testori, C; Warenits, AM; Weihs, W; Zeitlinger, M, 2016)
"Histological features of ischaemia and reperfusion injury were assessed."	1.40	Comparison of energy metabolism in liver grafts from donors after circulatory death and donors after brain death during cold storage and reperfusion. ( Ahmed, N; Mirza, DF; Murphy, N; Neil, DA; Perera, MT; Richards, DA; Silva, MA, 2014)
"Survival of children having cardiac arrest refractory to conventional cardiopulmonary resuscitation (CPR) is very poor."	1.40	Results of rapid-response extracorporeal cardiopulmonary resuscitation in children with refractory cardiac arrest following cardiac surgery. ( Al-Ahmadi, M; Al-Halees, Z; Alsoufi, B; Awan, A; Guechef, A; Kalloghlian, A; Manlhiot, C; McCrindle, BW, 2014)
" Catecholamine dosage was significantly reduced after ECMO implantation."	1.39	Single-center experience with extracorporeal life support in 103 nonpostcardiotomy patients. ( Arlt, M; Camboni, D; Hilker, M; Keyser, A; Lubnow, M; Lunz, D; Philipp, A; Rupprecht, L; Schmid, C; Schopka, S; Zacher, R; Zimmermann, M, 2013)
"We utilized a global cerebral ischemia model induced by arresting the heart with a combination of hypovolemia and intracardiac injections of a cold potassium chloride solution in order to study the potential therapeutic benefits of human mesenchymal stem cells (hMSCs) on global cerebral ischemia."	1.36	Therapeutic benefits of human mesenchymal stem cells derived from bone marrow after global cerebral ischemia. ( Hamada, H; Harada, K; Honmou, O; Houkin, K; Kocsis, JD; Liu, H; Miyata, K; Suzuki, J; Zheng, W, 2010)
"Acute cardiogenic shock or cardiac arrest (CS/CA) before cardiopulmonary bypass (CPB) installation are life-threatening events in acute coronary syndromes."	1.35	Continuous coronary sinus perfusion reverses ongoing myocardial damage in acute ischemia. ( Costanzo, FS; Cristodoro, L; Onorati, F; Renzulli, A; Santarpino, G; Scalas, C, 2009)
"Ventricular fibrillation was induced by angioplasty-balloon occlusion of the left coronary artery."	1.35	Percutaneous left ventricular assist device can prevent acute cerebral ischaemia during ventricular fibrillation. ( Epstein, A; Farstad, M; Grong, K; Husby, P; Nordrehaug, JE; Pettersen, RJ; Rotevatn, S; Tuseth, V; Wentzel-Larsen, T, 2009)
"After induction (t0) of cardiac arrest of 4 min, cardiopulmonary resuscitation was performed for 1 min, and the induced ventricular fibrillation was terminated by electrical defibrillation."	1.33	Xenon attenuates cerebral damage after ischemia in pigs. ( Glöggl, E; Marx, T; Reinelt, H; Schirmer, U; Schmidt, M, 2005)
"Metabolic acidosis is common in patients with cardiac arrest and is conventionally considered to be essentially due to hyperlactatemia."	1.33	A quantitative analysis of the acidosis of cardiac arrest: a prospective observational study. ( Bellomo, R; Makino, J; Morimatsu, H; Uchino, S, 2005)
"Echocardiography demonstrated that right ventricular dysfunction occurred in the absence of recruitment."	1.32	Atelectasis causes vascular leak and lethal right ventricular failure in uninjured rat lungs. ( Ackerley, C; Duggan, M; Engelberts, D; Kavanagh, BP; McCaul, CL; McNamara, PJ, 2003)
"After 4 min of cardiac arrest, followed by 3 min of basic life support CPR, 17 animals were randomly assigned to receive, every 5 min, either a combination of vasopressin and epinephrine (vasopressin [IU/kg]/epinephrine [ micro g/kg]: 0."	1.32	Survival with full neurologic recovery after prolonged cardiopulmonary resuscitation with a combination of vasopressin and epinephrine in pigs. ( Klima, GCDN; Krismer, AC; Lindner, KH; Mayr, VD; Pechlaner, S; Rheinberger, K; Stadlbauer, KH; Voelckel, WG; Wagner-Berger, HG; Wenzel, V, 2003)
"In contrast, cardiac arrest induced a rapid but variable decrease of interstitial glucose levels in all monitored organs; this decrease was followed by an increase over baseline during reperfusion."	1.32	Intestinal ischaemia during cardiac arrest and resuscitation: comparative analysis of extracellular metabolites by microdialysis. ( Bertsch, T; Denz, C; Ellinger, K; Henn, C; Janke, C; Klein, J; Korth, U; Krieter, H, 2003)
"After cardiac resuscitation, hypoxic encephalopathy often is the limiting factor regarding outcome due to the oxygen sensitivity of the brain."	1.32	Neurochemical monitoring using intracerebral microdialysis during cardiac resuscitation. ( Barbach, J; Bauer, R; Gabl, M; Galiano, K; Mohsenipour, I; Obwegeser, A, 2004)
"Lactate at 48 hours after cardiac arrest is an independent predictor of mortality and unfavorable neurologic outcome."	1.32	Serial lactate determinations for prediction of outcome after cardiac arrest. ( Havel, C; Holzer, M; Kliegel, A; Laggner, AN; Losert, H; Sterz, F; Zeiner, A, 2004)
"The mean occlusion time until cardiac arrest was 14."	1.31	Reduced postnatal cerebral glucose metabolism measured by PET after asphyxia in near term fetal lambs. ( Hellström-Westas, L; Hernandez-Andrade, E; Ley, D; Lingman, G; Marsal, K; Ohlsson, T; Oskarsson, G; Pesonen, E; Sandell, A; Strand, SE; Thorngren-Jerneck, K; Werner, O, 2001)
"The aim of the current study was to assess the effects of epinephrine in a pig model of hypothermic cardiac arrest followed by closed-chest cardiopulmonary resuscitation combined with active rewarming, simulating the clinical management of an arrested hypothermic patient in a hospital without cardiopulmonary bypass facilities."	1.31	Effects of epinephrine in a pig model of hypothermic cardiac arrest and closed-chest cardiopulmonary resuscitation combined with active rewarming. ( Kornberger, E; Krismer, AC; Lindner, KH; Mair, P; Mayr, VD; Rackwitz, KS; Schwarz, B; Wenzel, V, 2001)
"After cardiac arrest, the density of beta 2-adrenergic receptors (1858 +/- 188 sites/cell [p < ."	1.30	Regulation of beta 2-adrenergic receptors on mononuclear leukocytes in patients with acute ischemic heart disease. ( Anhäupl, T; Georgieff, M; Lindner, KH; Lurie, KG; Prengel, AW; Trunk, E, 1997)
"Cerebral blood flow after cardiac arrest is reduced during the delayed hypoperfusion phase, while cerebral metabolic rate of oxygen returns to baseline values."	1.30	Cerebrovascular reactivity in comatose patients resuscitated from a cardiac arrest. ( Buunk, G; Meinders, AE; van der Hoeven, JG, 1997)
"Ninety children were included in the study; 12 had major adverse events and there were 4 deaths."	1.30	Early markers of major adverse events in children after cardiac operations. ( Butt, W; Duke, T; Karl, TR; South, M, 1997)
"32 patients with out-of-hospital cardiac arrest; 14 of the patients had a return of spontaneous circulation (ROSC) and 18 of the patients died."	1.30	Ionized hypocalcemia during out-of-hospital cardiac arrest and cardiopulmonary resuscitation is not due to binding by lactate. ( Gando, S; Igarashi, M; Kameue, T; Nanzaki, S, 1997)
"To observe the influence of prolonged cardiac arrest times on neurologic outcome and heart resuscitability, using a resuscitation model with cardiopulmonary bypass in the rabbit, and to determine whether the changes in the plasma concentrations of lactate and lipoperoxide correlate with the severity of global brain ischemia."	1.29	Neurologic outcome and heart resuscitability with closed-chest cardiopulmonary bypass after prolonged cardiac arrest times in rabbits. ( Ogata, H; Xu, X, 1994)
"By inducing cardiopulmonary arrest (2-7 min) in 28 Wistar rats, ETCO2 and serum lactate levels were studied after and just before CPR, respectively."	1.29	End-tidal CO2 and plasma lactate level: a comparison of their use as parameters for evaluating successful CPR. ( Kimura, T; Naganuma, T; Okubo, N; Sato, S; Tanaka, M, 1993)
"Before cardiac arrest, the blood plasma glucose concentration in seven newborn (113 d postconception; normal gestation, 115 d) and seven 1-mo-old (144 d postconception) piglets was adjusted to a specific value (range, 1 to 64 mM), and then inspired ventilation gases were changed to 10:50:40 CO2:O2:N2 for 20 min."	1.29	The effect of hypercarbia on age-related changes in cerebral glucose transport and glucose-modulated agonal glycolytic rates. ( Corbett, RJ; Garcia, D; Laptook, AR; Sterett, R; Tollefsbol, G, 1993)
"The duration of cardiac arrest (DCA) in minutes and amount of epinephrine (milligrams) administered during ACLS was recorded."	1.28	Venous hyperoxia after cardiac arrest. Characterization of a defect in systemic oxygen utilization. ( Alexander, ME; Fenn, NM; Martin, GB; Nowak, RM; Rady, MY; Rivers, EP; Smithline, HA, 1992)
"Following prolonged cardiac arrest, reperfusion of the brain is endangered by the low blood perfusion pressure during the early resuscitation phase."	1.28	Two-stage resuscitation of the cat brain after prolonged cardiac arrest. ( Hossmann, KA; Ishimaru, S; Seo, K, 1991)
"Published results of dose-response effects of adrenergic drugs (epinephrine [E]) vary so much between studies because of differences in animal models and duration of ischemia before drug administration."	1.28	Comparison of different doses of epinephrine on myocardial perfusion and resuscitation success during cardiopulmonary resuscitation in a pig model. ( Ahnefeld, FW; Bowdler, IM; Lindner, KH, 1991)
"The average time from witnessed cardiac arrest to DMVA application was 81 +/- 9 minutes."	1.28	Direct mechanical ventricular actuation for cardiac arrest in humans. A clinical feasibility trial. ( Anstadt, GL; Anstadt, MP; Bartlett, RL; Brown, GR; Malone, JP; Martin, S; Nolan, DJ; Oberheu, KH, 1991)
"Neurologic outcome of hypoxic ischemic coma after cardiac arrest was studied in 32 patients."	1.27	Prediction of outcome after cardiac arrest. ( Edgren, E; Hedstrand, U; Nordin, M; Ronquist, G; Rydin, E, 1987)
"Rabbit hearts were subjected to cardiac arrest induced by injecting 3 isotonic cardioplegic solutions each of which contained in combination with procaine-HCl one of 3 different magnesium compounds."	1.26	Reperfusion effects on the magnesium-procaine arrested rabbit heart. ( Hölscher, B, 1981)

Research

Studies (148)

Authors

Clinical Trials (8)

Trial Overview

Trial Outcomes

Computed Cardiac Index

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (9.46)	18.7374
1990's	31 (20.95)	18.2507
2000's	29 (19.59)	29.6817
2010's	54 (36.49)	24.3611
2020's	20 (13.51)	2.80

Authors	Studies
He, Y	1
Wang, GX	1
Li, C	4
Wang, YX	1
Zhang, Q	2
Shastry, S	1
Manoochehri, O	1
Richardson, LD	1
Manini, AF	1
Hao, T	1
Jiang, Y	1
Wu, C	1
Chen, C	1
Xie, J	1
Pan, C	1
Guo, F	1
Huang, Y	1
Liu, L	1
Xie, H	1
Du, Z	1
Hou, X	1
Liu, S	1
Yang, Y	1
Qiu, H	1
Hashem, A	1
Mohamed, MS	1
Alabdullah, K	1
Elkhapery, A	1
Khalouf, A	1
Saadi, S	1
Nayfeh, T	1
Rai, D	1
Alali, O	1
Kinzelman-Vesely, EA	1
Parikh, V	1
Feitell, SC	1
Brux, H	1
Vom Dahl, J	2
Haake, H	2
Lundin, A	1
Annborn, M	2
Borgquist, O	1
Düring, J	1
Undén, J	1
Rylander, C	1
Kucher, NM	1
Marquez, AM	1
Guerguerian, AM	1
Moga, MA	1
Vargas-Gutierrez, M	1
Todd, M	1
Honjo, O	1
Haller, C	1
Goco, G	1
Floh, AA	1
Zhu, X	1
Li, J	3
Wang, H	1
Gasior, FM	1
Lee, C	1
Lin, S	1
Justice, CN	1
O'Donnell, JM	1
Vanden Hoek, TL	1
Gowers, SAN	1
Samper, IC	1
Murray, DRK	1
Smith, GK	1
Jeyaprakash, S	1
Rogers, ML	1
Karlsson, M	1
Olsen, MH	1
Møller, K	1
Boutelle, MG	1
da Silva, TOB	1
de Moura Vidal, LW	1
Cabral, PGA	1
da Mota Costa, MR	1
Cadena, SMR	1
Dos Santos Junior, MB	1
Antunes, F	1
de Abreu Oliveira, AL	1
Burstein, B	1
Vallabhajosyula, S	1
Ternus, B	1
Barsness, GW	1
Kashani, K	1
Jentzer, JC	1
López, J	1
Arias, P	1
Domenech, B	1
Horcajo, D	1
Nocete, JP	1
Zamora, L	1
Fernández, SN	1
López-Herce, J	2
Djarv, T	1
Issa, MS	1
Berg, KM	2
Donnino, MW	4
Abdullah, KQA	1
Roedler, JV	1
Szendey, I	1
Eckardt, L	1
Topf, A	1
Ohnewein, B	1
Jirak, P	1
Motloch, LJ	1
Wernly, B	2
Larbig, R	1
Santore, LA	1
Schurr, JW	1
Noubani, M	1
Rabenstein, A	1
Dhundale, K	1
Bilfinger, TV	1
McLarty, AJ	1
Seifert, FC	1
Sun, F	1
Mei, Y	1
Lv, J	1
Li, W	1
Hu, D	1
Zhang, G	1
Zhang, H	1
Zhang, J	1
Chen, X	1
Annoni, F	1
Peluso, L	1
Gouvêa Bogossian, E	1
Creteur, J	1
Zanier, ER	1
Taccone, FS	2
Lee, DH	1
Lee, BK	1
Jeung, KW	1
Jung, YH	1
Cho, YS	1
Youn, CS	1
Min, YI	1
Chang, RW	1
Luo, CM	1
Yu, HY	1
Chen, YS	1
Wang, CH	2
Yuan, W	1
Wu, JY	1
Zhao, YZ	1
Li, JB	1
Li, ZH	1
Li, CS	3
Hackmann, T	1
Skidmore, DL	1
MacManus, B	1
Koyama, Y	1
Mizutani, T	1
Marushima, A	1
Sonobe, A	1
Shimojo, N	1
Kawano, S	1
D'Arrigo, S	1
Cacciola, S	1
Dennis, M	1
Jung, C	3
Kagawa, E	1
Antonelli, M	1
Sandroni, C	1
Andersson, P	1
Frigyesi, A	1
Meert, K	1
Telford, R	1
Holubkov, R	1
Slomine, BS	1
Christensen, JR	1
Berger, J	1
Ofori-Amanfo, G	1
Newth, CJL	1
Dean, JM	1
Moler, FW	1
Zhang, Y	1
Yuan, XL	1
Ling, JY	1
Liang, Y	1
Liu, B	1
Zhao, LX	1
Sarıtaş, A	1
Çinleti, BA	1
Zincircioğlu, Ç	1
Uzun, U	1
Köse, I	1
Şenoğlu, N	1
Sumi, Y	1
Ledderose, C	1
Li, L	2
Inoue, Y	1
Okamoto, K	1
Kondo, Y	1
Sueyoshi, K	1
Junger, WG	1
Tanaka, H	1
Chae, MK	1
Lee, SE	1
Kang, SY	1
Sim, MS	1
Roedl, K	1
Jarczak, D	1
Becker, S	1
Fuhrmann, V	1
Kluge, S	1
Müller, J	1
Zhou, BC	1
Zhang, Z	1
Zhu, JJ	1
Liu, LJ	1
Liu, CF	1
Xu, W	1
Fu, Y	1
Jiang, L	2
Yang, Z	1
Wang, Y	1
Tang, W	2
Fang, X	1
Masyuk, M	1
Abel, P	1
Hug, M	1
Haneya, A	1
Sack, S	1
Sideris, K	1
Langwieser, N	1
Graf, T	1
Fuernau, G	2
Franz, M	1
Westenfeld, R	1
Kelm, M	1
Felix, SB	1
Fux, T	1
Holm, M	1
Corbascio, M	1
van der Linden, J	1
Rohm, CL	1
Gadidov, B	1
Leitson, M	1
Ray, HE	1
Prasad, R	1
Starodub, R	1
Abella, BS	2
Grossestreuer, AV	2
Shofer, FS	1
Perman, SM	1
Leary, M	1
Gaieski, DF	2
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Trial	Phase	Enrollment	Study Type	Start Date	Status
The Effect of Intra Aortic Balloon Pump Early Insertion on Mortality in Post Cardiac Arrest Patients With Acute Coronary Syndrome[NCT03638609]		102 participants (Anticipated)	Interventional	2017-10-23	Recruiting
The Relationship of Anesthesia Method With Serum Lactate Level in Craniotomies[NCT05145049]		110 participants (Actual)	Observational [Patient Registry]	2021-11-01	Completed
Evaluation of the Heart's Respiratory Quotient as Predictive Value After Extra-hospital[NCT04211207]		40 participants (Actual)	Observational	2020-01-27	Completed
Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study)[NCT02184169]		27 participants (Actual)	Interventional	2012-12-31	Completed
Emergency Resuscitative Endovascular Balloon Occlusion of the Aorta in Out of Hospital Cardiac Arrest[NCT06071910]		20 participants (Anticipated)	Interventional	2024-01-01	Not yet recruiting
Digestive ENdoscopy afTeR Out-of-hospitAl Cardiac arresT[NCT02349074]		221 participants (Actual)	Interventional	2014-11-12	Completed
The Thiamine Administration After Cardiac Surgery Trial[NCT04641104]	Phase 4	200 participants (Actual)	Interventional	2020-11-20	Completed
Evaluation of Prognosis Factors of Neurological Evolution in Cardiac Arrest : Prospective Study of Routine Care[NCT02849561]		82 participants (Actual)	Interventional	2014-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

A calculated estimate of cardiac index/systemic blood flow based on the Fick principle. (NCT02184169)
Timeframe: While mechanically ventilated, up to 14 days

Oxygen Consumption

Intervention	L/min/m2 (Mean)
Hypoplastic Left Heart Syndrome	1.3
Transposition of the Great Arteries	2.2

Oxygen consumption is the mass of oxygen gas consumed per minute, measured as the difference between oxygen mass inspired versus exhaled per minute. (NCT02184169)
Timeframe: While mechanically ventilated, up to 14 days

Article	Year
Predictors of Mortality in Patients With Refractory Cardiac Arrest Supported With VA-ECMO: A Systematic Review and a Meta-Analysis. Current problems in cardiology, 2023, Volume: 48, Issue:6 Topics: Aged; Cardiopulmonary Resuscitation; Extracorporeal Membrane Oxygenation; Female; Heart Arrest; Hosp	2023
Brain Protection after Anoxic Brain Injury: Is Lactate Supplementation Helpful? Cells, 2021, 07-06, Volume: 10, Issue:7 Topics: Acidosis; Animals; Brain Injuries, Traumatic; Cell Death; Cerebrovascular Circulation; Energy Metabo	2021
Predictors of favourable outcome after in-hospital cardiac arrest treated with extracorporeal cardiopulmonary resuscitation: A systematic review and meta-analysis. Resuscitation, 2017, Volume: 121 Topics: Adult; Age Factors; Biomarkers; Cardiopulmonary Resuscitation; Creatinine; Extracorporeal Membrane O	2017
Association of serum biomarkers with outcomes of cardiac arrest patients undergoing ECMO. The American journal of emergency medicine, 2018, Volume: 36, Issue:11 Topics: Adolescent; Adult; Biomarkers; Child; Child, Preschool; Creatinine; Extracorporeal Membrane Oxygenat	2018
Blood Lactate or Lactate Clearance: Which Is Robust to Predict the Neurological Outcomes after Cardiac Arrest? A Systematic Review and Meta-Analysis. BioMed research international, 2018, Volume: 2018 Topics: Biomarkers; Heart Arrest; Humans; Lactic Acid; Metabolic Clearance Rate; Nervous System Diseases	2018
Etiology and therapeutic approach to elevated lactate levels. Mayo Clinic proceedings, 2013, Volume: 88, Issue:10 Topics: Biomarkers; Drug-Related Side Effects and Adverse Reactions; Heart Arrest; Humans; Lactic Acid; PubM	2013
Etiology and therapeutic approach to elevated lactate levels. Mayo Clinic proceedings, 2013, Volume: 88, Issue:10 Topics: Biomarkers; Drug-Related Side Effects and Adverse Reactions; Heart Arrest; Humans; Lactic Acid; PubM	2013
Etiology and therapeutic approach to elevated lactate levels. Mayo Clinic proceedings, 2013, Volume: 88, Issue:10 Topics: Biomarkers; Drug-Related Side Effects and Adverse Reactions; Heart Arrest; Humans; Lactic Acid; PubM	2013
Etiology and therapeutic approach to elevated lactate levels. Mayo Clinic proceedings, 2013, Volume: 88, Issue:10 Topics: Biomarkers; Drug-Related Side Effects and Adverse Reactions; Heart Arrest; Humans; Lactic Acid; PubM	2013
Monitoring of the adult patient on venoarterial extracorporeal membrane oxygenation. TheScientificWorldJournal, 2014, Volume: 2014 Topics: Blood Gas Analysis; Extracorporeal Membrane Oxygenation; Heart Arrest; Heart Function Tests; Humans;	2014
Metabolic and electrolyte disturbance after cardiac arrest: How to deal with it. Best practice & research. Clinical anaesthesiology, 2015, Volume: 29, Issue:4 Topics: Blood Glucose; Electrolytes; Heart Arrest; Humans; Hyperglycemia; Lactic Acid; Metabolic Diseases; W	2015
Neuroimaging and serologic markers of neurologic injury after cardiac arrest. Neurologic clinics, 2006, Volume: 24, Issue:1 Topics: Blood Glucose; Brain; Brain Ischemia; Creatine Kinase; Heart Arrest; Humans; Lactic Acid; Magnetic R	2006
Prognostic value of blood lactate in critically ill patients. Resuscitation, 1984, Volume: 11, Issue:3-4 Topics: Acidosis; Acute Disease; Heart Arrest; Humans; Hypnotics and Sedatives; Intensive Care Units; Lactat	1984

Article	Year
Effect of Shenfu Injection () on Lactate and Lactate Clearance in Patients with Post-cardiac Arrest Syndrome: A Post Hoc Analysis of a Multicenter Randomized Controlled Trial. Chinese journal of integrative medicine, 2022, Volume: 28, Issue:10 Topics: Blood Glucose; Drugs, Chinese Herbal; Heart Arrest; Humans; Lactic Acid; Post-Cardiac Arrest Syndrom	2022
Paediatric in-hospital cardiac arrest: Factors associated with survival and neurobehavioural outcome one year later. Resuscitation, 2018, Volume: 124 Topics: Adolescent; Cardiopulmonary Resuscitation; Child; Child, Preschool; Cognitive Dysfunction; Coma; Epi	2018
Plasma Adenylate Levels are Elevated in Cardiopulmonary Arrest Patients and May Predict Mortality. Shock (Augusta, Ga.), 2019, Volume: 51, Issue:6 Topics: Adenosine Triphosphate; Adult; Aged; Aged, 80 and over; Disease-Free Survival; Female; Heart Arrest;	2019
Patterns of lactate values after congenital heart surgery and timing of cardiopulmonary support. The Annals of thoracic surgery, 2005, Volume: 80, Issue:4 Topics: Cardiopulmonary Resuscitation; Heart Arrest; Heart Defects, Congenital; Humans; Lactic Acid; Postope	2005
The use of cytosolic enzyme increase in cerebrospinal fluid of patients resuscitated after cardiac arrest. Brain Resuscitation Clinical Trial I Study Group. The American journal of emergency medicine, 1994, Volume: 12, Issue:6 Topics: Aspartate Aminotransferases; Brain Chemistry; Coma; Creatine Kinase; Heart Arrest; Humans; Injection	1994
Active compression-decompression cardiopulmonary resuscitation in standing position over the patient: pros and cons of a new method. Resuscitation, 1997, Volume: 34, Issue:1 Topics: Adult; Allied Health Personnel; Cardiopulmonary Resuscitation; Compressive Strength; Cross-Over Stud	1997

Article	Year
Cocaethylene cardiotoxicity in emergency department patients with acute drug overdose. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2023, Volume: 30, Issue:2 Topics: Adult; Cardiotoxicity; Cocaine; Drug Overdose; Emergency Service, Hospital; Ethanol; Heart Arrest; H	2023
Clinical outcome and risk factors for acute fulminant myocarditis supported by venoarterial extracorporeal membrane oxygenation: An analysis of nationwide CSECLS database in China. International journal of cardiology, 2023, Jan-15, Volume: 371 Topics: Adult; Extracorporeal Membrane Oxygenation; Heart Arrest; Humans; Lactic Acid; Male; Myocarditis; Re	2023
Lactate Level and Clearance as Predictors of Neurologic Outcome After Cardiopulmonary Resuscitation. American journal of critical care : an official publication, American Association of Critical-Care Nurses, 2023, 03-01, Volume: 32, Issue:2 Topics: Biomarkers; Cardiopulmonary Resuscitation; Heart Arrest; Humans; Lactic Acid; Retrospective Studies	2023
Veno-arterial CO Acta anaesthesiologica Scandinavica, 2023, Volume: 67, Issue:5 Topics: Carbon Dioxide; Heart Arrest; Humans; Lactic Acid; Prognosis; Shock	2023
Epinephrine Dosing Use During Extracorporeal Cardiopulmonary Resuscitation: Single-Center Retrospective Cohort. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2023, 11-01, Volume: 24, Issue:11 Topics: Adolescent; Cardiopulmonary Resuscitation; Child; Child, Preschool; Epinephrine; Heart Arrest; Human	2023
Nicotinamide restores tissue NAD+ and improves survival in rodent models of cardiac arrest. PloS one, 2023, Volume: 18, Issue:9 Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Heart Arrest; Lactic Acid; Mice; Myocytes,	2023
Real-time neurochemical measurement of dynamic metabolic events during cardiac arrest and resuscitation in a porcine model. The Analyst, 2020, Mar-07, Volume: 145, Issue:5 Topics: Aerococcus; Animals; Aspergillus niger; Biomarkers; Biosensing Techniques; Brain; Brain Ischemia; Ca	2020
Interventionist videothermometry: a new model of cardiac ischemia evaluation. BMC veterinary research, 2020, May-19, Volume: 16, Issue:1 Topics: Animals; Bicarbonates; Female; Heart; Heart Arrest; Lactic Acid; Myocardial Ischemia; Myocardium; Ra	2020
The Prognostic Value of Lactate in Cardiac Intensive Care Unit Patients With Cardiac Arrest and Shock. Shock (Augusta, Ga.), 2021, 05-01, Volume: 55, Issue:5 Topics: Aged; Aged, 80 and over; Biomarkers; Female; Heart Arrest; Hospital Mortality; Humans; Intensive Car	2021
Effect of ventilation rate on recovery after cardiac arrest in a pediatric animal model. PloS one, 2020, Volume: 15, Issue:8 Topics: Animals; Arterial Pressure; Asphyxia; Carbon Dioxide; Disease Models, Animal; Heart Arrest; Lactic A	2020
High lactate is common, not alone a reason to stop resuscitation in IHCA. Resuscitation, 2021, Volume: 160 Topics: Cardiopulmonary Resuscitation; Heart Arrest; Hospitals; Humans; Hypotension; Lactic Acid	2021
Reply to: High lactate is common, not alone a reason to stop resuscitation in IHCA. Resuscitation, 2021, Volume: 160 Topics: Cardiopulmonary Resuscitation; Heart Arrest; Hospitals; Humans; Hypotension; Lactic Acid	2021
Impella use in real-world cardiogenic shock patients: Sobering outcomes. PloS one, 2021, Volume: 16, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Critical Care; Critical Illness; Female; Heart Arrest; Heart-Assist	2021
SAVE score with lactate modification predicts in-hospital mortality in patients with ongoing cardiac arrest during VA-ECMO cannulation. The International journal of artificial organs, 2021, Volume: 44, Issue:10 Topics: Catheterization; Extracorporeal Membrane Oxygenation; Heart Arrest; Hospital Mortality; Humans; Lact	2021
Average mean arterial pressure in the first 6 hours of extracorporeal cardiopulmonary resuscitation in the prediction of the prognosis of neurological outcome: a single-center retrospective study. Perfusion, 2022, Volume: 37, Issue:8 Topics: Adult; Arterial Pressure; Cardiopulmonary Resuscitation; Heart Arrest; Humans; Lactic Acid; Prognosi	2022
Neuromuscular blockade requirement is associated with good neurologic outcome in cardiac arrest survivors treated with targeted temperature management. Journal of critical care, 2017, Volume: 40 Topics: Adult; Aged; Female; Heart Arrest; Hospital Mortality; Humans; Hypothermia, Induced; Lactic Acid; Mi	2017
Investigation of the pathophysiology of cardiopulmonary bypass using rodent extracorporeal life support model. BMC cardiovascular disorders, 2017, 05-15, Volume: 17, Issue:1 Topics: Animals; Asphyxia; Biomarkers; Cardiopulmonary Bypass; Carrier Proteins; Disease Models, Animal; Ext	2017
Comparison of early sequential hypothermia and delayed hypothermia on neurological function after resuscitation in a swine model. The American journal of emergency medicine, 2017, Volume: 35, Issue:11 Topics: Animals; Brain; Cardiopulmonary Resuscitation; Disease Models, Animal; Dopamine; Frontal Lobe; Gluco	2017
Case Report of Cardiac Arrest After Succinylcholine in a Child With Muscle-Eye-Brain Disease. A & A case reports, 2017, Oct-15, Volume: 9, Issue:8 Topics: Creatine Kinase; Female; Heart Arrest; Humans; Infant; Intraoperative Complications; Lactic Acid; Ne	2017
Cerebral Tissue Oxygenation Index Using Near-infrared Spectroscopy during Extracorporeal Cardio-pulmonary Resuscitation Predicted Good Neurological Recovery in a Patient with Acute Severe Anemia. Internal medicine (Tokyo, Japan), 2017, Sep-15, Volume: 56, Issue:18 Topics: Aged; Anemia; Blood Gas Analysis; Brain; Cardiopulmonary Resuscitation; Extracorporeal Membrane Oxyg	2017
Lactate improves SAPS 3 prognostication. Acta anaesthesiologica Scandinavica, 2018, Volume: 62, Issue:2 Topics: Adult; Aged; Critical Care; Female; Heart Arrest; Hospital Mortality; Humans; Lactic Acid; Male; Mid	2018
Effect of regional cerebral oximetry to estimate neurologic prognostic outcomes in patients administered targeted temperature management. The American journal of emergency medicine, 2018, Volume: 36, Issue:12 Topics: Adult; Aged; Brain; Cardiopulmonary Resuscitation; Female; Heart Arrest; Humans; Hypothermia, Induce	2018
Monitoring of Cerebral Metabolism in Postcardiac Arrest Patients: A Pilot Study. Therapeutic hypothermia and temperature management, 2018, Volume: 8, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Brain Injuries; Cerebrum; Female; Heart Arrest; Humans; Lactic Acid;	2018
Long-term neurological outcomes in patients aged over 90 years who are admitted to the intensive care unit following cardiac arrest. Resuscitation, 2018, Volume: 132 Topics: Aged, 80 and over; Cardiopulmonary Resuscitation; Case-Control Studies; Comorbidity; Female; Heart A	2018
Cardiopulmonary resuscitation ameliorates myocardial mitochondrial dysfunction in a cardiac arrest rat model. The American journal of emergency medicine, 2020, Volume: 38, Issue:1 Topics: Animals; Cardiopulmonary Resuscitation; Disease Models, Animal; Electrocardiography; Energy Metaboli	2020
Real-world clinical experience with the percutaneous extracorporeal life support system: Results from the German Lifebridge Clinical research in cardiology : official journal of the German Cardiac Society, 2020, Volume: 109, Issue:1 Topics: Aged; Cardiopulmonary Resuscitation; Cohort Studies; Critical Illness; Extracorporeal Membrane Oxyge	2020
Cardiac Arrest Prior to Venoarterial Extracorporeal Membrane Oxygenation: Risk Factors for Mortality. Critical care medicine, 2019, Volume: 47, Issue:7 Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Cardiopulmonary Resuscitation; Child; Comorbidity; Ex	2019
Predictors of Mortality and Outcomes of Acute Severe Cardiogenic Shock Treated with the Impella Device. The American journal of cardiology, 2019, 08-15, Volume: 124, Issue:4 Topics: Aged; Assisted Circulation; Carbon Dioxide; Cardiotonic Agents; Female; Heart Arrest; Heart-Assist D	2019
Association of serum lactate and survival outcomes in patients undergoing therapeutic hypothermia after cardiac arrest. Resuscitation, 2013, Volume: 84, Issue:8 Topics: Adult; Aged; Biomarkers; Cardiopulmonary Resuscitation; Female; Heart Arrest; Humans; Hypothermia, I	2013
Association of serum lactate and survival outcomes after cardiac arrest. Resuscitation, 2013, Volume: 84, Issue:8 Topics: Cardiopulmonary Resuscitation; Female; Heart Arrest; Humans; Hypothermia, Induced; Lactic Acid; Male	2013
Reply to letter: association of serum lactate and survival outcomes after cardiac arrest. Resuscitation, 2013, Volume: 84, Issue:8 Topics: Cardiopulmonary Resuscitation; Female; Heart Arrest; Humans; Hypothermia, Induced; Lactic Acid; Male	2013
Results of rapid-response extracorporeal cardiopulmonary resuscitation in children with refractory cardiac arrest following cardiac surgery. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2014, Volume: 45, Issue:2 Topics: Cardiac Surgical Procedures; Cardiopulmonary Resuscitation; Child; Child, Preschool; Extracorporeal	2014
Dynamic behavior of lactate values in venous-arterial extracorporeal membrane oxygenation for refractory cardiac arrest. Resuscitation, 2013, Volume: 84, Issue:12 Topics: Arteries; Extracorporeal Membrane Oxygenation; Female; Heart Arrest; Humans; Lactic Acid; Male; Midd	2013
Enhanced external counterpulsation improves cerebral blood flow following cardiopulmonary resuscitation. The American journal of emergency medicine, 2013, Volume: 31, Issue:12 Topics: Animals; Cardiopulmonary Resuscitation; Carotid Artery, Common; Case-Control Studies; Cerebral Corte	2013
Dynamic behaviour of lactate values during mild hypothermia in patients with cardiac arrest. European heart journal. Acute cardiovascular care, 2014, Volume: 3, Issue:2 Topics: Aged; Cohort Studies; Critical Care; Female; Heart Arrest; Hemodynamics; Humans; Hypothermia, Induce	2014
The noninvasive carbon dioxide gradient (NICO2G) during hemorrhagic shock. Shock (Augusta, Ga.), 2014, Volume: 42, Issue:1 Topics: Animals; Biomarkers; Blood Gas Monitoring, Transcutaneous; Breath Tests; Capnography; Carbon Dioxide	2014
Comparison of energy metabolism in liver grafts from donors after circulatory death and donors after brain death during cold storage and reperfusion. The British journal of surgery, 2014, Volume: 101, Issue:7 Topics: Adult; Aged; Brain Death; Cryopreservation; Energy Metabolism; Glycerol; Graft Survival; Heart Arres	2014
Arterial lactate levels in an emergency department are associated with mortality: a prospective observational cohort study. Emergency medicine journal : EMJ, 2015, Volume: 32, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Emergency Service, Hospital; Female; Heart Arrest; H	2015
Post return of spontaneous circulation factors associated with mortality in pediatric in-hospital cardiac arrest: a prospective multicenter multinational observational study. Critical care (London, England), 2014, Nov-03, Volume: 18, Issue:6 Topics: Adolescent; Carbon Dioxide; Child; Child, Preschool; Heart Arrest; Hospital Mortality; Humans; Hydro	2014
Comparison of Shenfu Injection () and epinephrine on catecholamine levels in a porcine model of prolonged cardiac arrest. Chinese journal of integrative medicine, 2016, Volume: 22, Issue:5 Topics: Animals; Cardiac Output; Cardiopulmonary Resuscitation; Catecholamines; Disease Models, Animal; Drug	2016
Predictors of neurological outcomes after successful extracorporeal cardiopulmonary resuscitation. BMC anesthesiology, 2015, Volume: 15 Topics: Aged; Brain; Brain Death; Cardiopulmonary Resuscitation; Extracorporeal Membrane Oxygenation; Female	2015
Evaluation of Serum Lactate, Central Venous Saturation, and Venous-Arterial Carbon Dioxide Difference in the Prediction of Mortality in Postcardiac Arrest Syndrome. Journal of intensive care medicine, 2016, Volume: 31, Issue:8 Topics: Aged; Blood Gas Analysis; Carbon Dioxide; Cardiac Output; Female; Heart Arrest; Humans; Lactic Acid;	2016
[Analysis of early lactate clearance rate in prognosis of neural function of patients with cardiac arrest]. Zhonghua yi xue za zhi, 2015, May-19, Volume: 95, Issue:19 Topics: Heart Arrest; Humans; Lactic Acid; Metabolic Clearance Rate; Prognosis; Resuscitation	2015
Outcome predictors in cardiopulmonary resuscitation facilitated by extracorporeal membrane oxygenation. Clinical research in cardiology : official journal of the German Cardiac Society, 2016, Volume: 105, Issue:3 Topics: Aged; Aged, 80 and over; Biomarkers; Cardiopulmonary Resuscitation; Extracorporeal Membrane Oxygenat	2016
Monitoring of serum lactate level during cardiopulmonary resuscitation in adult in-hospital cardiac arrest. Critical care (London, England), 2015, Sep-21, Volume: 19 Topics: Aged; Aged, 80 and over; Cardiopulmonary Resuscitation; Female; Heart Arrest; Hospitalization; Human	2015
Intestinal Conditioning After Cardiac Arrest: The Use of Normothermic Extracorporeal Membrane Oxygenation in the Non-Heart-Beating Animal Model. Artificial organs, 2016, Volume: 40, Issue:8 Topics: Adenosine Triphosphate; Animals; Apoptosis; Body Temperature; Disease Models, Animal; Energy Metabol	2016
Microdialysis Assessment of Cerebral Perfusion during Cardiac Arrest, Extracorporeal Life Support and Cardiopulmonary Resuscitation in Rats - A Pilot Trial. PloS one, 2016, Volume: 11, Issue:5 Topics: Animals; Biomarkers; Blood Pressure; CA1 Region, Hippocampal; Cardiopulmonary Resuscitation; Cerebra	2016
Validation of the Intensive Care Unit Early Warning Dashboard: Quality Improvement Utilizing a Retrospective Case-Control Evaluation. Telemedicine journal and e-health : the official journal of the American Telemedicine Association, 2017, Volume: 23, Issue:2 Topics: Age Factors; Aged; Algorithms; Case-Control Studies; Decision Support Systems, Clinical; Diabetes Me	2017
Phosphodiesterase Inhibitor-Based Vasodilation Improves Oxygen Delivery and Clinical Outcomes Following Stage 1 Palliation. Journal of the American Heart Association, 2016, 11-02, Volume: 5, Issue:11 Topics: Blalock-Taussig Procedure; Cardiopulmonary Resuscitation; Extracorporeal Membrane Oxygenation; Femal	2016
Strong ion gap and outcome after cardiac arrest: another nail in the coffin of traditional acid-base quantification. Intensive care medicine, 2009, Volume: 35, Issue:2 Topics: Acid-Base Equilibrium; Acid-Base Imbalance; Acidosis; Analysis of Variance; Biomechanical Phenomena;	2009
Cerebral energy failure following experimental cardiac arrest Hypothermia treatment reduces secondary lactate/pyruvate-ratio increase. Resuscitation, 2009, Volume: 80, Issue:5 Topics: Animals; Brain; Brain Ischemia; Cardiopulmonary Resuscitation; Cerebrovascular Circulation; Disease	2009
Percutaneous left ventricular assist device can prevent acute cerebral ischaemia during ventricular fibrillation. Resuscitation, 2009, Volume: 80, Issue:10 Topics: Acute Disease; Animals; Blood Flow Velocity; Brain Ischemia; Cardiac Catheterization; Cerebrovascula	2009
Outcomes after extracorporeal cardiopulmonary resuscitation (ECPR) following refractory pediatric cardiac arrest in the intensive care unit. Resuscitation, 2009, Volume: 80, Issue:10 Topics: Adolescent; Alanine Transaminase; Cardiopulmonary Resuscitation; Child; Child, Preschool; Extracorpo	2009
Bupivacaine-induced cardiac arrest: fat is good-is epinephrine really bad? Anesthesiology, 2009, Volume: 111, Issue:3 Topics: Anesthetics, Local; Bupivacaine; Epinephrine; Fat Emulsions, Intravenous; Heart Arrest; Hemodynamics	2009
Combination pharmacotherapy in the treatment of experimental cardiac arrest. The American journal of emergency medicine, 2009, Volume: 27, Issue:6 Topics: Adrenergic beta-Agonists; Animals; Atenolol; Cardiotonic Agents; Disease Models, Animal; Drug Therap	2009
Haemodynamic consequences of mild therapeutic hypothermia after cardiac arrest. European journal of anaesthesiology, 2010, Volume: 27, Issue:4 Topics: Aged; Blood Pressure; Cardiac Output; Clinical Protocols; Diuresis; Emergency Medical Services; Fema	2010
Therapeutic benefits of human mesenchymal stem cells derived from bone marrow after global cerebral ischemia. Brain research, 2010, Jan-15, Volume: 1310 Topics: Analysis of Variance; Animals; Bone Marrow Cells; Brain Ischemia; Brain-Derived Neurotrophic Factor;	2010
Continuous coronary sinus perfusion reverses ongoing myocardial damage in acute ischemia. Artificial organs, 2009, Volume: 33, Issue:10 Topics: Acute Coronary Syndrome; Aged; Biomarkers; Cardiopulmonary Bypass; Cardiotonic Agents; Coronary Arte	2009
Resuscitation of severely asphyctic newborn pigs with cardiac arrest by using 21% or 100% oxygen. Neonatology, 2010, Volume: 98, Issue:1 Topics: Animals; Animals, Newborn; Asphyxia; Blood Pressure; Carbon Dioxide; Cardiopulmonary Resuscitation;	2010
Fetal cerebral energy metabolism and electrocardiogram during experimental umbilical cord occlusion and resuscitation. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2010, Volume: 23, Issue:2 Topics: Animals; Brain; Brain Chemistry; Cardiopulmonary Resuscitation; Disease Models, Animal; Electrocardi	2010
Evaluation of cerebral metabolism by ¹H-magnetic resonance spectroscopy for 4°C saline-induced therapeutic hypothermia in pig model of cardiac arrest. The American journal of emergency medicine, 2011, Volume: 29, Issue:8 Topics: Animals; Brain; Cardiac Output; Disease Models, Animal; Female; Heart Arrest; Heart Rate; Hemodynami	2011
The effects of carvedilol administration on cardiopulmonary resuscitation in a rat model of cardiac arrest induced by airway obstruction. Anesthesia and analgesia, 2010, Volume: 111, Issue:5 Topics: Administration, Oral; Adrenergic Antagonists; Airway Obstruction; Animals; Biomarkers; Blood Glucose	2010
Post-cardiotomy extracorporeal cardiopulmonary resuscitation in neonates with complex single ventricle: analysis of outcomes. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2011, Volume: 40, Issue:6 Topics: Cardiopulmonary Resuscitation; Epidemiologic Methods; Extracorporeal Membrane Oxygenation; Female; H	2011
The association of lactate and vasopressor need for mortality prediction in survivors of cardiac arrest. Minerva anestesiologica, 2011, Volume: 77, Issue:11 Topics: Aged; Area Under Curve; Calibration; Cohort Studies; Female; Heart Arrest; Humans; Lactic Acid; Logi	2011
The association of lactate and vasopressor need for mortality prediction in survivors of cardiac arrest. Minerva anestesiologica, 2011, Volume: 77, Issue:11 Topics: Aged; Area Under Curve; Calibration; Cohort Studies; Female; Heart Arrest; Humans; Lactic Acid; Logi	2011
The association of lactate and vasopressor need for mortality prediction in survivors of cardiac arrest. Minerva anestesiologica, 2011, Volume: 77, Issue:11 Topics: Aged; Area Under Curve; Calibration; Cohort Studies; Female; Heart Arrest; Humans; Lactic Acid; Logi	2011
The association of lactate and vasopressor need for mortality prediction in survivors of cardiac arrest. Minerva anestesiologica, 2011, Volume: 77, Issue:11 Topics: Aged; Area Under Curve; Calibration; Cohort Studies; Female; Heart Arrest; Humans; Lactic Acid; Logi	2011
Can lactate levels and vasopressors use predict outcome in out-of-hospital cardiac arrest survivors? Minerva anestesiologica, 2011, Volume: 77, Issue:11 Topics: Female; Heart Arrest; Humans; Lactic Acid; Male; Vasoconstrictor Agents	2011
Cerebrospinal fluid biochemistry reflects effects of therapeutic hypothermia after cardiac arrest in a porcine model. The American journal of emergency medicine, 2012, Volume: 30, Issue:8 Topics: Animals; Body Temperature; Disease Models, Animal; Glucose; Glutamic Acid; Glycerol; Heart Arrest; H	2012
Factors predicting outcome of cardiopulmonary resuscitation among elderly Malaysians: a retrospective study. The Medical journal of Malaysia, 2012, Volume: 67, Issue:3 Topics: Age Factors; Aged; Cardiopulmonary Resuscitation; Female; Heart Arrest; Humans; Lactic Acid; Malaysi	2012
Determination of glyphosate and AMPA in blood and urine from humans: about 13 cases of acute intoxication. Forensic science international, 2013, Mar-10, Volume: 226, Issue:1-3 Topics: Accidents; Acidosis; Adult; Aged; Arrhythmias, Cardiac; Chemical and Drug Induced Liver Injury; Chro	2013
Heparin-binding protein: an early indicator of critical illness and predictor of outcome in cardiac arrest. Resuscitation, 2013, Volume: 84, Issue:7 Topics: Aged; Antimicrobial Cationic Peptides; APACHE; Biomarkers; Blood Proteins; Carrier Proteins; Female;	2013
Single-center experience with extracorporeal life support in 103 nonpostcardiotomy patients. Artificial organs, 2013, Volume: 37, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arterial Pressure; Biomarkers; Cardiovascular Agents; Ca	2013
Effect of intra-aortic occlusion balloon in external thoracic compressions during CPR in pigs. The American journal of emergency medicine, 2002, Volume: 20, Issue:5 Topics: Animals; Blood Gas Analysis; Breath Tests; Capnography; Carbon Dioxide; Cardiac Output; Cardiopulmon	2002
Hypertonic saline improves myocardial blood flow during CPR, but is not enhanced further by the addition of hydroxy ethyl starch. Resuscitation, 2003, Volume: 56, Issue:3 Topics: Animals; Blood Pressure; Cardiac Output; Cardiopulmonary Resuscitation; Coronary Circulation; Fluid	2003
Atelectasis causes vascular leak and lethal right ventricular failure in uninjured rat lungs. American journal of respiratory and critical care medicine, 2003, Jun-15, Volume: 167, Issue:12 Topics: Animals; Blood Gas Analysis; Capillary Leak Syndrome; Disease Models, Animal; Echocardiography; Func	2003
Survival with full neurologic recovery after prolonged cardiopulmonary resuscitation with a combination of vasopressin and epinephrine in pigs. Anesthesia and analgesia, 2003, Volume: 96, Issue:6 Topics: Animals; Blood Gas Analysis; Blood Pressure; Body Weight; Cardiopulmonary Resuscitation; Drug Combin	2003
[Metformin-associated lactic acidosis remains a serious complication of metformin therapy]. Annales francaises d'anesthesie et de reanimation, 2003, Volume: 22, Issue:5 Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Aged; Diabetes Complications; Diabetes Mellitus, Type	2003
Intestinal ischaemia during cardiac arrest and resuscitation: comparative analysis of extracellular metabolites by microdialysis. Resuscitation, 2003, Volume: 58, Issue:2 Topics: Animals; Brain; Cardiopulmonary Resuscitation; Choline; Extracellular Space; Glucose; Glutamic Acid;	2003
Elective cardiac arrest: lactic acid production in the arrested heart. The Journal of physiology, 1957, Feb-15, Volume: 135, Issue:2 Topics: Heart Arrest; Lactic Acid	1957
Molar sodium lactate compared with electrical stimulation in cardiac arrest. Journal of the American Medical Association, 1957, Jul-13, Volume: 164, Issue:11 Topics: Electric Stimulation; Enzyme Inhibitors; Heart Arrest; Humans; Lactic Acid; Molar; Sodium Lactate	1957
[The behavior of phosphocreatinine, adenosine nucleotides, orthophosphate, glycogen and lactic acid in the myocardium in different forms of heart arrest]. Thoraxchirurgie, 1961, Volume: 9 Topics: Adenosine; Coenzymes; Glycogen; Heart Arrest; Lactates; Lactic Acid; Myocardium; Nucleotides; Phosph	1961
[Phosphorus compounds and lactic acid in the tissues of the brain and heart in hypothermic animals during cardiac arrest and during restoration of systemic circulation by combined medical procedures]. Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1959, Volume: 45 Topics: Animals; Brain; Brain Chemistry; Heart; Heart Arrest; Hypothermia; Hypothermia, Induced; Lactates; L	1959
Neurochemical monitoring using intracerebral microdialysis during cardiac resuscitation. Intensive care medicine, 2004, Volume: 30, Issue:1 Topics: Adult; Biomarkers; Brain Chemistry; Cause of Death; Cerebral Infarction; Energy Metabolism; Fatal Ou	2004
Is magnetic resonance spectroscopy superior to conventional diagnostic tools in hypoxic-ischemic encephalopathy? Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2004, Volume: 14, Issue:2 Topics: Aspartic Acid; Brain; Brain Death; Cell Death; Choline; Coma; Creatine; Diffusion Magnetic Resonance	2004
Serial lactate determinations for prediction of outcome after cardiac arrest. Medicine, 2004, Volume: 83, Issue:5 Topics: Age Factors; Aged; Biomarkers; Electrocardiography; Emergency Medical Services; Female; Follow-Up St	2004
Xenon attenuates cerebral damage after ischemia in pigs. Anesthesiology, 2005, Volume: 102, Issue:5 Topics: Anesthesia, Intravenous; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Body Temperature; Bra	2005
A quantitative analysis of the acidosis of cardiac arrest: a prospective observational study. Critical care (London, England), 2005, Volume: 9, Issue:4 Topics: Acidosis; Adult; Chlorides; Comorbidity; Female; Heart Arrest; Humans; Lactic Acid; Male; Middle Age	2005
Survival after marked hyperlactaemia. Anaesthesia, 2006, Volume: 61, Issue:5 Topics: Acetaminophen; Adult; Alcohol Drinking; Analgesics, Non-Narcotic; Critical Care; Dextropropoxyphene;	2006
Arterial minus end-tidal CO2 as a prognostic factor of hospital survival in patients resuscitated from cardiac arrest. Resuscitation, 2007, Volume: 72, Issue:2 Topics: Algorithms; Blood Gas Analysis; Carbon Dioxide; Cardiopulmonary Resuscitation; Emergency Service, Ho	2007
Effective lactate clearance is associated with improved outcome in post-cardiac arrest patients. Resuscitation, 2007, Volume: 75, Issue:2 Topics: Biomarkers; Cardiopulmonary Resuscitation; Female; Follow-Up Studies; Heart Arrest; Humans; Lactic A	2007
Effective lactate clearance is associated with improved outcome in post-cardiac arrest patients. Resuscitation, 2007, Volume: 75, Issue:2 Topics: Biomarkers; Cardiopulmonary Resuscitation; Female; Follow-Up Studies; Heart Arrest; Humans; Lactic A	2007
Effective lactate clearance is associated with improved outcome in post-cardiac arrest patients. Resuscitation, 2007, Volume: 75, Issue:2 Topics: Biomarkers; Cardiopulmonary Resuscitation; Female; Follow-Up Studies; Heart Arrest; Humans; Lactic A	2007
Effective lactate clearance is associated with improved outcome in post-cardiac arrest patients. Resuscitation, 2007, Volume: 75, Issue:2 Topics: Biomarkers; Cardiopulmonary Resuscitation; Female; Follow-Up Studies; Heart Arrest; Humans; Lactic A	2007
The effect of ischaemia on the activity of pyruvate dehydrogenase complex in rat heart. Journal of molecular and cellular cardiology, 1984, Volume: 16, Issue:8 Topics: Adenosine Triphosphate; Animals; Coronary Disease; Diabetes Mellitus, Experimental; Dietary Fats; He	1984
Reperfusion effects on the magnesium-procaine arrested rabbit heart. Arzneimittel-Forschung, 1981, Volume: 31, Issue:11 Topics: Animals; Electrocardiography; Glycogen; Heart Arrest; Lactates; Lactic Acid; Magnesium; Mitochondria	1981
Residual metabolism of the hypothermic-arrested pig heart. The Journal of surgical research, 1981, Volume: 31, Issue:4 Topics: Adenine Nucleotides; Animals; Heart Arrest; Heart Arrest, Induced; Hydrogen-Ion Concentration; Hypot	1981
Effect of extracorporeal life support on cerebral blood flow, metabolism and electrophysiology in normothermic cats. Intensive care medicine, 1995, Volume: 21, Issue:1 Topics: Animals; Brain; Brain Chemistry; Cats; Cerebrovascular Circulation; Electrophysiology; Evaluation St	1995
Rapid recovery of rat brain intracellular pH after cardiac arrest and resuscitation. Brain research, 1995, Jul-31, Volume: 687, Issue:1-2 Topics: Acidosis; Adenosine Triphosphate; Animals; Body Temperature; Brain Chemistry; Cardiopulmonary Resusc	1995
Mechanisms of myocardial hypercarbic acidosis during cardiac arrest. Journal of applied physiology (Bethesda, Md. : 1985), 1995, Volume: 78, Issue:4 Topics: Acidosis; Animals; Blood Flow Velocity; Carbon Dioxide; Coronary Circulation; Disease Models, Animal	1995
Early determination of neurological outcome after prehospital cardiopulmonary resuscitation. Stroke, 1995, Volume: 26, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Cardiopulmonary Resuscitation; Ele	1995
Acidemia and brain pH during prolonged cardiopulmonary resuscitation in dogs. Stroke, 1995, Volume: 26, Issue:6 Topics: Acidosis; Adenosine Triphosphate; Analysis of Variance; Animals; Brain; Brain Stem; Cardiopulmonary	1995
Preconditioning with a single short episode of global ischemia in the isolated working rat heart: effect on structure, mechanical function, and energy metabolism for various durations of sustained global ischemia. Cardiovascular drugs and therapy, 1995, Volume: 9, Issue:1 Topics: Animals; Chromatography, High Pressure Liquid; Energy Metabolism; Glycogen; Heart; Heart Arrest; In	1995
Neurologic outcome and heart resuscitability with closed-chest cardiopulmonary bypass after prolonged cardiac arrest times in rabbits. Critical care medicine, 1994, Volume: 22, Issue:12 Topics: Analysis of Variance; Animals; Brain Ischemia; Cardiopulmonary Bypass; Disease Models, Animal; Femal	1994
The effect of hypercarbia on age-related changes in cerebral glucose transport and glucose-modulated agonal glycolytic rates. Pediatric research, 1993, Volume: 34, Issue:3 Topics: Acidosis, Lactic; Age Factors; Animals; Animals, Newborn; Animals, Suckling; Biological Transport; B	1993
Establishing a resuscitation model in rabbits with closed-thoracic cardiopulmonary by-pass. Resuscitation, 1994, Volume: 27, Issue:1 Topics: Animals; Cardiopulmonary Bypass; Disease Models, Animal; Electroencephalography; Female; Heart Arres	1994
End-tidal CO2 and plasma lactate level: a comparison of their use as parameters for evaluating successful CPR. Resuscitation, 1993, Volume: 26, Issue:2 Topics: Animals; Carbon Dioxide; Cardiopulmonary Resuscitation; Heart Arrest; Lactates; Lactic Acid; Rats; R	1993
Intramyocardial hypercarbic acidosis during cardiac arrest and resuscitation. Critical care medicine, 1993, Volume: 21, Issue:6 Topics: Acidosis, Respiratory; Animals; Carbon Dioxide; Disease Models, Animal; Heart Arrest; Hemodynamics;	1993
Regulation of beta 2-adrenergic receptors on mononuclear leukocytes in patients with acute ischemic heart disease. Critical care medicine, 1997, Volume: 25, Issue:4 Topics: Acute Disease; Aged; Angina Pectoris; Blood Glucose; Cardiopulmonary Resuscitation; Catecholamines;	1997
Cerebrovascular reactivity in comatose patients resuscitated from a cardiac arrest. Stroke, 1997, Volume: 28, Issue:8 Topics: Adult; Aged; Aged, 80 and over; Blood Flow Velocity; Cerebral Arteries; Cerebrovascular Circulation;	1997
Early markers of major adverse events in children after cardiac operations. The Journal of thoracic and cardiovascular surgery, 1997, Volume: 114, Issue:6 Topics: Blood Pressure; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cohort Studies; Heart Arrest; H	1997
Ionized hypocalcemia during out-of-hospital cardiac arrest and cardiopulmonary resuscitation is not due to binding by lactate. Intensive care medicine, 1997, Volume: 23, Issue:12 Topics: Aged; Calcium; Cardiopulmonary Resuscitation; Female; Heart Arrest; Humans; Hypocalcemia; Lactic Aci	1997
[Mechanisms of actovegin effect on the central nervous system during postischemic period]. Biulleten' eksperimental'noi biologii i meditsiny, 1998, Volume: 126, Issue:10 Topics: Animals; Brain; Carotid Arteries; Glucose; Heart Arrest; Heme; Hemodynamics; Hemorrhage; Injections,	1998
Effects of hematocrit on cerebral microcirculation and tissue oxygenation during deep hypothermic bypass. Circulation, 2001, Sep-18, Volume: 104, Issue:12 Suppl 1 Topics: Animals; Body Temperature; Cardiopulmonary Bypass; Cell Adhesion; Cell Count; Cerebrovascular Circul	2001
Effects of epinephrine in a pig model of hypothermic cardiac arrest and closed-chest cardiopulmonary resuscitation combined with active rewarming. Resuscitation, 2001, Volume: 50, Issue:3 Topics: Analysis of Variance; Animals; Blood Gas Analysis; Body Temperature; Cardiopulmonary Resuscitation;	2001
Comparison of lactate or BE during out-of-hospital cardiac arrest to determine metabolic acidosis. Resuscitation, 2001, Volume: 51, Issue:3 Topics: Acidosis; Aged; Blood Gas Analysis; Cardiopulmonary Resuscitation; Female; Heart Arrest; Humans; Lac	2001
Reduced postnatal cerebral glucose metabolism measured by PET after asphyxia in near term fetal lambs. Journal of neuroscience research, 2001, Dec-01, Volume: 66, Issue:5 Topics: Acidosis; Animals; Animals, Newborn; Asphyxia Neonatorum; Blood Pressure; Cerebral Cortex; Cerebrova	2001
Advantages of Celsior solution in graft preservation from non-heart-beating donors in a canine liver transplantation model. The Journal of surgical research, 2002, Volume: 102, Issue:2 Topics: Adenosine; Alanine Transaminase; Allopurinol; Animals; Aspartate Aminotransferases; Disaccharides; D	2002
Neurological outcome after experimental cardiopulmonary resuscitation: a result of delayed and potentially treatable neuronal injury? Acta anaesthesiologica Scandinavica, 2002, Volume: 46, Issue:5 Topics: Angioplasty, Balloon, Coronary; Animals; Cardiopulmonary Resuscitation; Cerebrovascular Circulation;	2002
Proton magnetic resonance spectroscopy of brain after cardiac resuscitation. Lancet (London, England), 1992, Oct-10, Volume: 340, Issue:8824 Topics: Brain; Cardiopulmonary Resuscitation; Female; Heart Arrest; Humans; Lactates; Lactic Acid; Magnetic	1992
Venous hyperoxia after cardiac arrest. Characterization of a defect in systemic oxygen utilization. Chest, 1992, Volume: 102, Issue:6 Topics: Aged; Epinephrine; Female; Heart Arrest; Humans; Lactates; Lactic Acid; Male; Middle Aged; Oxygen; O	1992
Prevention of postischemic canine neurological injury through potentiation of brain energy metabolism by acetyl-L-carnitine. Stroke, 1992, Volume: 23, Issue:9 Topics: Acetylcarnitine; Animals; Brain; Brain Ischemia; Dogs; Energy Metabolism; Female; Heart Arrest; Lact	1992
Two-stage resuscitation of the cat brain after prolonged cardiac arrest. Intensive care medicine, 1991, Volume: 17, Issue:7 Topics: Adenosine Triphosphate; Animals; Brain Chemistry; Cardiopulmonary Resuscitation; Cats; Cerebrovascul	1991
Regional changes in intracellular pH determined by neutral red histophotometry and high energy metabolites during cardiac arrest and following resuscitation in the rat. Metabolic brain disease, 1991, Volume: 6, Issue:3 Topics: Adenosine Triphosphate; Animals; Brain; Glucose; Heart Arrest; Hippocampus; Hydrogen-Ion Concentrati	1991
Metabolic and functional cardiac impairment after reperfusion with persantine. The Journal of surgical research, 1991, Volume: 51, Issue:2 Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Dipyridamole; Heart; Heart Arrest; Hemodynami	1991
Comparison of different doses of epinephrine on myocardial perfusion and resuscitation success during cardiopulmonary resuscitation in a pig model. The American journal of emergency medicine, 1991, Volume: 9, Issue:1 Topics: Animals; Carbon Dioxide; Cerebrovascular Circulation; Coronary Circulation; Dose-Response Relationsh	1991
Direct mechanical ventricular actuation for cardiac arrest in humans. A clinical feasibility trial. Chest, 1991, Volume: 100, Issue:1 Topics: Blood Pressure; Carbon Dioxide; Cardiac Output; Electrocardiography; Heart Arrest; Heart Massage; He	1991
Ionized hypocalcemia during prolonged cardiac arrest and closed-chest CPR in a canine model. Annals of emergency medicine, 1991, Volume: 20, Issue:11 Topics: Animals; Arteries; Blood Pressure; Calcium; Carbon Dioxide; Cardiopulmonary Resuscitation; Dogs; Fem	1991
Cerebral lactate uptake during cardiopulmonary resuscitation in humans. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1991, Volume: 11, Issue:3 Topics: Aged; Aged, 80 and over; Aorta; Arteries; Brain; Heart Arrest; Humans; Jugular Veins; Lactates; Lact	1991
Increases in coronary vein CO2 during cardiac resuscitation. Journal of applied physiology (Bethesda, Md. : 1985), 1990, Volume: 68, Issue:4 Topics: Animals; Aorta; Blood; Carbon Dioxide; Coronary Vessels; Female; Heart Arrest; Hydrogen-Ion Concentr	1990
Buffer agents do not reverse intramyocardial acidosis during cardiac resuscitation. Circulation, 1990, Volume: 81, Issue:5 Topics: Acidosis; Animals; Bicarbonates; Blood; Buffers; Carbon Dioxide; Carbonates; Disease Models, Animal;	1990
Physiology of blood flow and oxygen utilization by peripheral tissue in circulatory shock. Clinical chemistry, 1990, Volume: 36, Issue:8 Pt 2 Topics: Blood Flow Velocity; Heart Arrest; Hemodynamics; Humans; Lactates; Lactic Acid; Oxygen Consumption;	1990
The effect of cardiopulmonary bypass resuscitation on cardiac arrest induced lactic acidosis in dogs. Resuscitation, 1989, Volume: 17, Issue:2 Topics: Acidosis, Lactic; Animals; Cardiopulmonary Bypass; Dogs; Heart Arrest; Lactates; Lactic Acid; Oxygen	1989
Carbon-13 and phosphorus-31 nuclear magnetic resonance studies of myocardial metabolism in live guinea pigs. Advances in myocardiology, 1985, Volume: 6 Topics: Adenosine Triphosphate; Animals; Carbon Isotopes; Coronary Disease; Energy Metabolism; Female; Gluco	1985
Role of myocardial ischemia during programmed stimulation in survivors of cardiac arrest with coronary artery disease. Journal of the American College of Cardiology, 1987, Volume: 9, Issue:5 Topics: Angioplasty, Balloon; Cardiac Pacing, Artificial; Coronary Artery Bypass; Coronary Disease; Follow-U	1987
Effect of dichloroacetate in the treatment of anoxic lactic acidosis in dogs. Critical care medicine, 1986, Volume: 14, Issue:11 Topics: Acetates; Acidosis, Lactic; Animals; Bicarbonates; Carbon Dioxide; Dichloroacetic Acid; Dogs; Heart	1986
Serum lactate: prognostic marker for recurrent cardiac arrest? American heart journal, 1987, Volume: 113, Issue:6 Topics: Blood Pressure; Echocardiography; Heart Arrest; Heart Rate; Humans; Lactates; Lactic Acid; Osmolar C	1987
Prediction of outcome after cardiac arrest. Critical care medicine, 1987, Volume: 15, Issue:9 Topics: Adenylate Kinase; Adult; Aged; Brain Damage, Chronic; Coma; Electroencephalography; Female; Glutathi	1987

lactic acid and Asystole