lactic acid has been researched along with Astrocytoma in 21 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The choline/NAA ratio was 3." | 2.40 | Proton MR spectroscopic characteristics of pediatric pilocytic astrocytomas. ( Ball, WS; Ballard, E; Dunn, RS; Egnaczyk, GF; Holland, SK; Hwang, JH, 1998) |
| "Proton MRS of pediatric posterior fossa tumors seems to be helpful in prediction of tumor grading and histology." | 1.31 | [Clinical application of proton magnetic resonance spectroscopy for differential diagnosis of pediatric posterior fossa tumors]. ( Biegański, T; Kreisel, J; Liberski, PP; Nowosławska, E; Polis, L; Zakrzewski, K, 2001) |
| "Eleven primitive neuroectodermal tumors (patient age, 2 to 12 years; mean, 7 years), 11 low-grade astrocytomas (age, 2 to 16 years; mean, 9 years), 4 ependymomas (age, 1 to 6 years; mean, 4 years), 1 mixed glioma ependymo-astrocytoma (age, 11 years), 1 anaplastic ependymoma (age, 7 years), 1 ganglioglioma (age, 14 years), and 1 malignant teratoma (age, 6 days) were studied." | 1.29 | Proton MR spectroscopy of pediatric cerebellar tumors. ( Bilaniuk, LT; Cnaan, A; Haselgrove, JC; Rorke, LB; Sutton, LN; Wang, Z; Zhao, H; Zimmerman, RA, 1995) |
| "Lonidamine (LND) has been shown to inhibit tumor aerobic glycolysis." | 1.27 | Effect of lonidamine on human malignant gliomas: biochemical studies. ( Caputo, A; Carapella, CM; Del Carlo, C; Fanciulli, M; Floridi, A; Giorno, S; Paggi, MG; Silvestrini, B; Zupi, G, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.76) | 18.7374 |
| 1990's | 7 (33.33) | 18.2507 |
| 2000's | 12 (57.14) | 29.6817 |
| 2010's | 1 (4.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McLean, MA | 2 |
| Sun, A | 1 |
| Bradstreet, TE | 1 |
| Schaeffer, AK | 1 |
| Liu, H | 2 |
| Iannone, R | 1 |
| Herman, G | 1 |
| Railkar, RA | 1 |
| Joubert, I | 1 |
| Gillard, JH | 1 |
| Price, SJ | 1 |
| Griffiths, JR | 2 |
| Howe, FA | 1 |
| Barton, SJ | 1 |
| Cudlip, SA | 1 |
| Stubbs, M | 1 |
| Saunders, DE | 1 |
| Murphy, M | 1 |
| Wilkins, P | 1 |
| Opstad, KS | 1 |
| Doyle, VL | 1 |
| Bell, BA | 1 |
| Bulakbasi, N | 1 |
| Kocaoglu, M | 1 |
| Ors, F | 1 |
| Tayfun, C | 1 |
| Uçöz, T | 1 |
| Yang, Y | 1 |
| Basu, S | 1 |
| Tomasko, DL | 1 |
| Lee, LJ | 1 |
| Yang, ST | 1 |
| Jenkinson, MD | 1 |
| Smith, TS | 1 |
| Joyce, K | 1 |
| Fildes, D | 1 |
| du Plessis, DG | 1 |
| Warnke, PC | 1 |
| Walker, C | 1 |
| Beckner, ME | 1 |
| Gobbel, GT | 1 |
| Abounader, R | 1 |
| Burovic, F | 1 |
| Agostino, NR | 1 |
| Laterra, J | 1 |
| Pollack, IF | 1 |
| Pulkkinen, J | 1 |
| Häkkinen, AM | 1 |
| Lundbom, N | 1 |
| Paetau, A | 1 |
| Kauppinen, RA | 1 |
| Hiltunen, Y | 1 |
| Lemire, J | 1 |
| Mailloux, RJ | 1 |
| Appanna, VD | 1 |
| Preul, MC | 1 |
| Caramanos, Z | 1 |
| Collins, DL | 1 |
| Villemure, JG | 1 |
| Leblanc, R | 1 |
| Olivier, A | 1 |
| Pokrupa, R | 1 |
| Arnold, DL | 1 |
| Wang, Z | 1 |
| Sutton, LN | 1 |
| Cnaan, A | 1 |
| Haselgrove, JC | 1 |
| Rorke, LB | 1 |
| Zhao, H | 1 |
| Bilaniuk, LT | 1 |
| Zimmerman, RA | 1 |
| Siderowf, AD | 1 |
| Balcer, LJ | 1 |
| Kenyon, LC | 1 |
| Nei, M | 1 |
| Raps, EC | 1 |
| Galetta, SL | 1 |
| Hwang, JH | 1 |
| Egnaczyk, GF | 1 |
| Ballard, E | 1 |
| Dunn, RS | 1 |
| Holland, SK | 1 |
| Ball, WS | 1 |
| Meyerand, ME | 1 |
| Pipas, JM | 1 |
| Mamourian, A | 1 |
| Tosteson, TD | 1 |
| Dunn, JF | 1 |
| Dezortová, M | 1 |
| Hájek, M | 1 |
| Cáp, F | 1 |
| Babis, M | 1 |
| Tichý, M | 1 |
| Vymazal, J | 1 |
| Graves, EE | 1 |
| Nelson, SJ | 1 |
| Vigneron, DB | 1 |
| Chin, C | 1 |
| Verhey, L | 1 |
| McDermott, M | 1 |
| Larson, D | 1 |
| Sneed, PK | 1 |
| Chang, S | 1 |
| Prados, MD | 1 |
| Lamborn, K | 1 |
| Dillon, WP | 1 |
| Ricci, PE | 1 |
| Pitt, A | 1 |
| Keller, PJ | 1 |
| Coons, SW | 1 |
| Heiserman, JE | 1 |
| Hall, WA | 1 |
| Martin, AJ | 1 |
| Truwit, CL | 1 |
| Ishimaru, H | 1 |
| Morikawa, M | 1 |
| Iwanaga, S | 1 |
| Kaminogo, M | 1 |
| Ochi, M | 1 |
| Hayashi, K | 1 |
| Zakrzewski, K | 1 |
| Kreisel, J | 1 |
| Polis, L | 1 |
| Nowosławska, E | 1 |
| Liberski, PP | 1 |
| Biegański, T | 1 |
| Henriksen, O | 1 |
| Wieslander, S | 1 |
| Gjerris, F | 1 |
| Jensen, KM | 1 |
| Paggi, MG | 1 |
| Carapella, CM | 1 |
| Fanciulli, M | 1 |
| Del Carlo, C | 1 |
| Giorno, S | 1 |
| Zupi, G | 1 |
| Silvestrini, B | 1 |
| Caputo, A | 1 |
| Floridi, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Development of Magnetic Resonance Spectroscopy (MRS) Biomarkers of Tumor Metabolism[NCT01138813] | 8 participants (Actual) | Observational | 2009-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for lactic acid and Astrocytoma
| Article | Year |
|---|---|
Proton MR spectroscopic characteristics of pediatric pilocytic astrocytomas.
Topics: Aspartic Acid; Astrocytoma; Brain Neoplasms; Child; Child, Preschool; Choline; Humans; Infant; Lacti | 1998 |
20 other studies available for lactic acid and Astrocytoma
| Article | Year |
|---|---|
Repeatability of edited lactate and other metabolites in astrocytoma at 3T.
Topics: Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Female; Humans; Lactic Acid; Magnetic Resonance Spe | 2012 |
Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy.
Topics: Alanine; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatine; Glioblastoma; Humans; Inosi | 2003 |
Combination of single-voxel proton MR spectroscopy and apparent diffusion coefficient calculation in the evaluation of common brain tumors.
Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creat | 2003 |
Fabrication of well-defined PLGA scaffolds using novel microembossing and carbon dioxide bonding.
Topics: Animals; Astrocytoma; Biocompatible Materials; Carbon Dioxide; Cell Adhesion; Cell Culture Technique | 2005 |
MRS of oligodendroglial tumors: correlation with histopathology and genetic subtypes.
Topics: Adult; Aged; Allelic Imbalance; Astrocytoma; Brain Neoplasms; Choline; Chromosomes, Human, Pair 1; C | 2005 |
Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis.
Topics: Astrocytoma; Cell Adhesion; Cell Line, Tumor; Cell Movement; Collagen; Drug Combinations; Enzyme Inh | 2005 |
Independent component analysis to proton spectroscopic imaging data of human brain tumours.
Topics: Algorithms; Aspartic Acid; Astrocytoma; Brain Neoplasms; Cell Proliferation; Choline; Creatine; Glio | 2005 |
Mitochondrial lactate dehydrogenase is involved in oxidative-energy metabolism in human astrocytoma cells (CCF-STTG1).
Topics: Adenosine Triphosphate; Astrocytoma; Cell Line, Tumor; Cell Respiration; Energy Metabolism; Humans; | 2008 |
Accurate, noninvasive diagnosis of human brain tumors by using proton magnetic resonance spectroscopy.
Topics: Adult; Alanine; Aspartic Acid; Astrocytoma; Biomarkers; Brain; Brain Neoplasms; Choline; Creatine; D | 1996 |
Proton MR spectroscopy of pediatric cerebellar tumors.
Topics: Adolescent; Aspartic Acid; Astrocytoma; Brain Chemistry; Cerebellar Neoplasms; Child; Child, Prescho | 1995 |
Central neurogenic hyperventilation in an awake patient with a pontine glioma.
Topics: Astrocytoma; Brain Neoplasms; Cerebrospinal Fluid; Humans; Hydrogen-Ion Concentration; Hyperventilat | 1996 |
Classification of biopsy-confirmed brain tumors using single-voxel MR spectroscopy.
Topics: Adult; Aged; Analysis of Variance; Aspartic Acid; Astrocytoma; Biopsy; Body Water; Brain Neoplasms; | 1999 |
Comparison of MR spectroscopy and MR imaging with contrast agent in children with cerebral astrocytomas.
Topics: Adolescent; Astrocytoma; Brain; Brain Neoplasms; Child; Child, Preschool; Contrast Media; Gadolinium | 1999 |
A preliminary study of the prognostic value of proton magnetic resonance spectroscopic imaging in gamma knife radiosurgery of recurrent malignant gliomas.
Topics: Adult; Aged; Aspartic Acid; Astrocytoma; Choline; Creatine; Female; Glioblastoma; Humans; Lactic Aci | 2000 |
Effect of voxel position on single-voxel MR spectroscopy findings.
Topics: Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Glio | 2000 |
An efficient chemical shift imaging scheme for magnetic resonance-guided neurosurgery.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Biopsy; Brain; Brain Mapping; Brain Neop | 2001 |
Differentiation between high-grade glioma and metastatic brain tumor using single-voxel proton MR spectroscopy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Chil | 2001 |
[Clinical application of proton magnetic resonance spectroscopy for differential diagnosis of pediatric posterior fossa tumors].
Topics: Adolescent; Aspartic Acid; Astrocytoma; Child; Child, Preschool; Choline; Creatine; Diagnosis, Diffe | 2001 |
In vivo 1H-spectroscopy of human intracranial tumors at 1.5 tesla. Preliminary experience at a clinical installation.
Topics: Adult; Aged; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatine; Female; Humans; Lactate | 1991 |
Effect of lonidamine on human malignant gliomas: biochemical studies.
Topics: Astrocytoma; Deoxy Sugars; Deoxyglucose; Glycolysis; Hexokinase; Humans; Indazoles; Lactates; Lactic | 1988 |