Page last updated: 2024-10-17

lactic acid and Asphyxia

lactic acid has been researched along with Asphyxia in 34 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Asphyxia: A pathological condition caused by lack of oxygen, manifested in impending or actual cessation of life.

Research Excerpts

ExcerptRelevanceReference
" Our aim was to use magnetic resonance spectroscopy (MRS) biomarkers and immunohistochemistry to investigate the cerebral effects of the NHE inhibitor, methyl isobutyl amiloride (MIA) given after severe perinatal asphyxia in the piglet."7.79Methyl-isobutyl amiloride reduces brain Lac/NAA, cell death and microglial activation in a perinatal asphyxia model. ( Bainbridge, A; Cady, E; Chandrasekaran, M; Cheong, J; Faulkner, S; Hristova, M; Iwata, O; Iwata, S; Kapetanakis, A; Kato, T; Raivich, G; Robertson, NJ, 2013)
"SIDS was further divided into SIDS without additional findings and SIDS with secondary findings which contributed to death."5.27Lactic acid concentrations in vitreous humor: their use in asphyxial deaths in children. ( Sturner, WQ; Sullivan, A; Suzuki, K, 1983)
" Our aim was to use magnetic resonance spectroscopy (MRS) biomarkers and immunohistochemistry to investigate the cerebral effects of the NHE inhibitor, methyl isobutyl amiloride (MIA) given after severe perinatal asphyxia in the piglet."3.79Methyl-isobutyl amiloride reduces brain Lac/NAA, cell death and microglial activation in a perinatal asphyxia model. ( Bainbridge, A; Cady, E; Chandrasekaran, M; Cheong, J; Faulkner, S; Hristova, M; Iwata, O; Iwata, S; Kapetanakis, A; Kato, T; Raivich, G; Robertson, NJ, 2013)
" An increased lactate level was found in asphyctic infants and a clear correlation between lactic acidosis and foetal distress was documented."3.74Prevention of cerebral palsy during labour: role of foetal lactate. ( Borruto, F; Comparetto, C; Treisser, A, 2008)
"Lactic acid levels were high immediately after ROSC in both groups, but were significantly lower in the 20 rpm group at 30 (3."1.56Effect of ventilation rate on recovery after cardiac arrest in a pediatric animal model. ( Arias, P; Domenech, B; Fernández, SN; Horcajo, D; López, J; López-Herce, J; Nocete, JP; Zamora, L, 2020)
"The rats underwent 5 min of untreated asphyxial cardiac arrest and were resuscitated by ECLS for 30 min."1.46Investigation of the pathophysiology of cardiopulmonary bypass using rodent extracorporeal life support model. ( Chang, RW; Chen, YS; Luo, CM; Wang, CH; Yu, HY, 2017)
"Fetal asphyxia was induced by occlusion of the umbilical cord for 25 min (n = 10)."1.33White matter injury following prolonged free radical formation in the 0.65 gestation fetal sheep brain. ( Arvidsson, P; Kjellmer, I; Lindblom, A; Mallard, C; Nilsson, UA; Sandberg, M; Welin, AK, 2005)
"During seizures SMABF fell significantly (8."1.32The role of the sympathetic nervous system in postasphyxial intestinal hypoperfusion in the pre-term sheep fetus. ( Bennet, L; Gunn, AJ; Heineman, E; Quaedackers, JS; Roelfsema, V, 2004)
"SIDS was further divided into SIDS without additional findings and SIDS with secondary findings which contributed to death."1.27Lactic acid concentrations in vitreous humor: their use in asphyxial deaths in children. ( Sturner, WQ; Sullivan, A; Suzuki, K, 1983)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19905 (14.71)18.7374
1990's2 (5.88)18.2507
2000's16 (47.06)29.6817
2010's10 (29.41)24.3611
2020's1 (2.94)2.80

Authors

AuthorsStudies
López, J1
Arias, P1
Domenech, B1
Horcajo, D1
Nocete, JP1
Zamora, L1
Fernández, SN1
López-Herce, J1
Chang, RW1
Luo, CM1
Yu, HY1
Chen, YS1
Wang, CH1
Cheung, PY2
Miedzyblocki, M1
Lee, TF1
Bigam, DL1
Karabayir, N1
Demirel, A1
Bayramoglu, E1
Fert-Bober, J1
Sawicki, G1
Lopaschuk, GD1
Yan, EB1
Baburamani, AA1
Walker, AM1
Walker, DW1
Solevåg, AL1
Dannevig, I1
Nakstad, B1
Saugstad, OD2
Frizzo, JK1
Cardoso, MP1
de Assis, AM1
Perry, ML1
Volonté, C1
Frizzo, ME2
Pfeil, A2
Pfeifer, R1
Böttcher, J1
Neumann, R1
Axer, H1
Schmidt, P1
Herzog, A1
Kaiser, WA1
Wolf, G1
Hansch, A1
Faulkner, S2
Bainbridge, A2
Kato, T2
Chandrasekaran, M2
Kapetanakis, AB1
Hristova, M2
Liu, M1
Evans, S1
De Vita, E1
Kelen, D1
Sanders, RD1
Edwards, AD1
Maze, M1
Cady, EB1
Raivich, G2
Robertson, NJ2
Castagnetti, C1
Mariella, J1
Pirrone, A1
Cinotti, S1
Mari, G1
Peli, A1
Iwata, O1
Kapetanakis, A1
Cheong, J1
Iwata, S1
Cady, E1
Souza, SK1
Martins, TL1
Ferreira, GD1
Vinagre, AS1
Silva, RS1
Hunter, CJ1
Bennet, L4
Power, GG1
Roelfsema, V3
Blood, AB1
Quaedackers, JS4
George, S1
Guan, J1
Gunn, AJ4
DANIEL, SS1
MORISHIMA, HO1
JAMES, LS1
ADAMSONS, K1
Heineman, E1
Solas, AB1
Munkeby, BH1
Godfried, MH1
Boer, K1
Beuger, S1
Scherpbier, HJ1
Kuijpers, TW1
Ahmad, R1
Hasnain, AU1
Fraser, M1
Van Heeswijk, JC1
Van Pelt, J1
Van den Thillart, GE1
Welin, AK1
Sandberg, M1
Lindblom, A1
Arvidsson, P1
Nilsson, UA1
Kjellmer, I2
Mallard, C1
Booth, LC1
Ahmed-Nasef, N1
Dean, JM1
Davidson, J1
Juul, SE1
Aylward, E1
Richards, T1
McPherson, RJ1
Kuratani, J1
Burbacher, TM1
Borruto, F1
Comparetto, C1
Treisser, A1
Hendrickx, HH1
Safar, P1
Baer, BP1
Basford, RE1
Sturner, WQ1
Sullivan, A1
Suzuki, K1
Thiringer, K1
Blomstrand, S1
Hrbek, A1
Karlsson, K1
de Haan, HH1
Ijzermans, AC1
de Haan, J1
Van Belle, H1
Hasaart, TH1
Chateil, JF1
Quesson, B1
Brun, M1
Thiaudière, E1
Sarlangue, J1
Delalande, C1
Billeaud, C1
Canioni, P1
Diard, F1
Ikeda, T1
Murata, Y1
Quilligan, EJ1
Parer, JT1
Murayama, T1
Koono, M1
Seidl, R1
Stöckler-Ipsiroglu, S1
Rolinski, B1
Kohlhauser, C1
Herkner, KR1
Lubec, B1
Lubec, G1
Davies, DR1
Davies, DD1
Kita, T1
Furuya, Y1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Standardizing the Definition and Approach to a Clinically Significant Cardiopulmonary Event in Infants Less Than 30 Weeks on Length of Stay[NCT03414671]160 participants (Actual)Observational2018-06-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

34 other studies available for lactic acid and Asphyxia

ArticleYear
Effect of ventilation rate on recovery after cardiac arrest in a pediatric animal model.
    PloS one, 2020, Volume: 15, Issue:8

    Topics: Animals; Arterial Pressure; Asphyxia; Carbon Dioxide; Disease Models, Animal; Heart Arrest; Lactic A

2020
Investigation of the pathophysiology of cardiopulmonary bypass using rodent extracorporeal life support model.
    BMC cardiovascular disorders, 2017, 05-15, Volume: 17, Issue:1

    Topics: Animals; Asphyxia; Biomarkers; Cardiopulmonary Bypass; Carrier Proteins; Disease Models, Animal; Ext

2017
Effects of post-resuscitation administration with sodium hydrosulfide on cardiac recovery in hypoxia-reoxygenated newborn piglets.
    European journal of pharmacology, 2013, Oct-15, Volume: 718, Issue:1-3

    Topics: Animals; Animals, Newborn; Asphyxia; Biological Transport; Blood Gas Analysis; Female; Glutathione;

2013
Blood lactate level and meconium aspiration syndrome.
    Archives of gynecology and obstetrics, 2015, Volume: 291, Issue:4

    Topics: Apgar Score; Asphyxia; Delivery, Obstetric; Female; Fetal Distress; Gestational Age; Humans; Infant;

2015
Proteomic analysis of cardiac metabolic enzymes in asphyxiated newborn piglets.
    Molecular and cellular biochemistry, 2008, Volume: 318, Issue:1-2

    Topics: Animals; Animals, Newborn; Asphyxia; Electrophoresis, Gel, Two-Dimensional; Heart Function Tests; He

2008
Changes in cerebral blood flow, cerebral metabolites, and breathing movements in the sheep fetus following asphyxia produced by occlusion of the umbilical cord.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 297, Issue:1

    Topics: Animals; Asphyxia; Biomarkers; Blood Flow Velocity; Blood Pressure; Brain; Carbon Dioxide; Cerebrova

2009
Resuscitation of severely asphyctic newborn pigs with cardiac arrest by using 21% or 100% oxygen.
    Neonatology, 2010, Volume: 98, Issue:1

    Topics: Animals; Animals, Newborn; Asphyxia; Blood Pressure; Carbon Dioxide; Cardiopulmonary Resuscitation;

2010
Effects of acute perinatal asphyxia in the rat hippocampus.
    Cellular and molecular neurobiology, 2010, Volume: 30, Issue:5

    Topics: Acute Disease; Animals; Animals, Newborn; Asphyxia; Biological Transport; Cell Survival; Female; Glu

2010
[Cerebral hypoxia or cyanide intoxication?].
    MMW Fortschritte der Medizin, 2010, Oct-28, Volume: 152, Issue:43

    Topics: Adult; Air Pollutants, Occupational; Asphyxia; Diagnosis, Differential; Female; Humans; Hydrogen Cya

2010
Xenon augmented hypothermia reduces early lactate/N-acetylaspartate and cell death in perinatal asphyxia.
    Annals of neurology, 2011, Volume: 70, Issue:1

    Topics: Administration, Inhalation; Animals; Animals, Newborn; Aspartic Acid; Asphyxia; Cell Death; Hypother

2011
Expression of interleukin-1β, interleukin-8, and interferon-γ in blood samples obtained from healthy and sick neonatal foals.
    American journal of veterinary research, 2012, Volume: 73, Issue:9

    Topics: Animals; Animals, Newborn; Asphyxia; Fibrinogen; Horse Diseases; Horses; Interferon-gamma; Interleuk

2012
Methyl-isobutyl amiloride reduces brain Lac/NAA, cell death and microglial activation in a perinatal asphyxia model.
    Journal of neurochemistry, 2013, Volume: 124, Issue:5

    Topics: Amiloride; Animals; Aspartic Acid; Asphyxia; Brain; Cell Death; Disease Models, Animal; Hypoxia-Isch

2013
Metabolic effects of perinatal asphyxia in the rat cerebral cortex.
    Metabolic brain disease, 2013, Volume: 28, Issue:1

    Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Animals; Animals, Newborn; Asphyxia; Blood Glucose; C

2013
Key neuroprotective role for endogenous adenosine A1 receptor activation during asphyxia in the fetal sheep.
    Stroke, 2003, Volume: 34, Issue:9

    Topics: Animals; Asphyxia; Blood Gas Analysis; Body Temperature; Brain; Calorimetry; Cell Count; Cerebrovasc

2003
LACTATE AND PYRUVATE GRADIENTS BETWEEN RED BLOOD CELLS AND PLASMA DURING ACUTE ASPHYXIA.
    Journal of applied physiology, 1964, Volume: 19

    Topics: Asphyxia; Biological Transport; Blood; Cell Membrane Permeability; Erythrocytes; Glucose; Guinea Pig

1964
The role of the sympathetic nervous system in postasphyxial intestinal hypoperfusion in the pre-term sheep fetus.
    The Journal of physiology, 2004, Jun-15, Volume: 557, Issue:Pt 3

    Topics: Animals; Asphyxia; Blood Gas Analysis; Blood Glucose; Blood Pressure; Electroencephalography; Electr

2004
Comparison of short- and long-duration oxygen treatment after cerebral asphyxia in newborn piglets.
    Pediatric research, 2004, Volume: 56, Issue:1

    Topics: Animals; Animals, Newborn; Asphyxia; Blood Pressure; Carbon Dioxide; Cerebral Cortex; Cerebrovascula

2004
A neonate with macrosomia, cardiomyopathy and hepatomegaly born to an HIV-infected mother.
    European journal of pediatrics, 2005, Volume: 164, Issue:3

    Topics: Adipose Tissue; Antiretroviral Therapy, Highly Active; Arginine; Asphyxia; Brain; Cardiomegaly; Card

2005
Ontogenetic changes and developmental adjustments in lactate dehydrogenase isozymes of an obligate air-breathing fish Channa punctatus during deprivation of air access.
    Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 2005, Volume: 140, Issue:2

    Topics: Adaptation, Physiological; Air; Animals; Asphyxia; Fishes; Hypoxia; Isoenzymes; Kinetics; L-Lactate

2005
Cortisol and ACTH responses to severe asphyxia in preterm fetal sheep.
    Experimental physiology, 2005, Volume: 90, Issue:4

    Topics: Adrenocorticotropic Hormone; Animals; Asphyxia; Blood Gas Analysis; Blood Glucose; Female; Fetal Blo

2005
Free fatty acid metabolism in the air-breathing African catfish (Clarias gariepinus) during asphyxia.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2005, Volume: 141, Issue:1

    Topics: Africa; Animals; Asphyxia; Catfishes; Fatty Acids, Nonesterified; Hematocrit; Hemoglobins; Lactic Ac

2005
White matter injury following prolonged free radical formation in the 0.65 gestation fetal sheep brain.
    Pediatric research, 2005, Volume: 58, Issue:1

    Topics: Animals; Antioxidants; Ascorbic Acid; Asphyxia; Brain; Dehydroascorbic Acid; Electron Spin Resonance

2005
Male disadvantage? Fetal sex and cardiovascular responses to asphyxia in preterm fetal sheep.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2007, Volume: 293, Issue:3

    Topics: Animals; Animals, Newborn; Asphyxia; Blood Gas Analysis; Blood Glucose; Blood Pressure; Carotid Arte

2007
Prenatal cord clamping in newborn Macaca nemestrina: a model of perinatal asphyxia.
    Developmental neuroscience, 2007, Volume: 29, Issue:4-5

    Topics: Animals; Animals, Newborn; Asphyxia; Brain; Disease Models, Animal; Electroencephalography; Erythrop

2007
Prevention of cerebral palsy during labour: role of foetal lactate.
    Archives of gynecology and obstetrics, 2008, Volume: 278, Issue:1

    Topics: Acidosis, Lactic; Apgar Score; Asphyxia; Cerebral Palsy; Extraction, Obstetrical; Female; Fetal Bloo

2008
Brain lactate and alanine-glutamate ratios during and after asphyxia in rats.
    Resuscitation, 1984, Volume: 12, Issue:2

    Topics: Alanine; Animals; Asphyxia; Brain; Cerebrovascular Circulation; Glutamates; Glutamic Acid; Lactates;

1984
Lactic acid concentrations in vitreous humor: their use in asphyxial deaths in children.
    Journal of forensic sciences, 1983, Volume: 28, Issue:1

    Topics: Asphyxia; Blood Glucose; Child, Preschool; Forensic Medicine; Humans; Infant; Infant, Newborn; Lacta

1983
Cerebral arterio-venous difference for hypoxanthine and lactate during graded asphyxia in the fetal lamb.
    Brain research, 1982, May-06, Volume: 239, Issue:1

    Topics: Animals; Asphyxia; Blood Pressure; Cerebral Arteries; Cerebrovascular Circulation; Evoked Potentials

1982
Effects of surgery and asphyxia on levels of nucleosides, purine bases, and lactate in cerebrospinal fluid of fetal lambs.
    Pediatric research, 1994, Volume: 36, Issue:5

    Topics: Adenosine Triphosphate; Animals; Asphyxia; Female; Fetal Hypoxia; Fetus; Lactates; Lactic Acid; Nucl

1994
Localised proton magnetic resonance spectroscopy of the brain after perinatal hypoxia: a preliminary report.
    Pediatric radiology, 1999, Volume: 29, Issue:3

    Topics: Aspartic Acid; Asphyxia; Brain; Choline; Creatine; Follow-Up Studies; Humans; Hypoxia; Infant, Newbo

1999
Histologic and biochemical study of the brain, heart, kidney, and liver in asphyxia caused by occlusion of the umbilical cord in near-term fetal lambs.
    American journal of obstetrics and gynecology, 2000, Volume: 182, Issue:2

    Topics: Animals; Asphyxia; Blood Gas Analysis; Brain; Female; Fetus; Glutathione; Kidney; Lactic Acid; Liver

2000
Energy metabolism in graded perinatal asphyxia of the rat.
    Life sciences, 2000, Jun-16, Volume: 67, Issue:4

    Topics: Adenine Nucleotides; Animals; Animals, Newborn; Asphyxia; Blood Gas Analysis; Brain; Chromatography,

2000
D-lactate and the false suffocation alarm.
    Archives of general psychiatry, 2002, Volume: 59, Issue:3

    Topics: Arousal; Asphyxia; Humans; Lactic Acid; Panic; Panic Disorder; Stereoisomerism

2002
[Mechanisms of the pulmonary congestion in ligature strangulation (IV)].
    Igaku kenkyu. Acta medica, 1989, Volume: 59, Issue:1

    Topics: Animals; Asphyxia; Bradykinin; Ferritins; Fibrinolysin; Guinea Pigs; Lactates; Lactic Acid; Ligation

1989