lactic acid has been researched along with Arthritis, Rheumatoid in 38 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Self-reinforcing polylevolactic acid (SR-PLLA) implants have been used in arthrodeses of patients with rheumatoid arthritis." | 7.71 | Long-term results of ankle and triple arthrodeses fixed with self-reinforced polylevolactic acid implants in patients with rheumatoid arthritis. ( Juutilainen, T; Partio, EK; Pätiälä, H; Rokkanen, P; Voutilainen, N, 2001) |
| "Methotrexate (MTX), as a disease modifying antirheumatic drug (DMARD), was first line drug to treat rheumatoid arthritis." | 3.88 | Dual-functional lipid polymeric hybrid pH-responsive nanoparticles decorated with cell penetrating peptide and folate for therapy against rheumatoid arthritis. ( Lee, RJ; Li, Y; Sun, F; Sun, X; Teng, L; Yu, C; Zhang, X; Zhao, J; Zhao, M; Zhou, Y, 2018) |
| "Self-reinforcing polylevolactic acid (SR-PLLA) implants have been used in arthrodeses of patients with rheumatoid arthritis." | 3.71 | Long-term results of ankle and triple arthrodeses fixed with self-reinforced polylevolactic acid implants in patients with rheumatoid arthritis. ( Juutilainen, T; Partio, EK; Pätiälä, H; Rokkanen, P; Voutilainen, N, 2001) |
| "Inflammation is involved in many disease processes." | 1.56 | Lactate Production Precedes Inflammatory Cell Recruitment in Arthritic Ankles: an Imaging Study. ( Beziere, N; Bouzin, C; Comment, A; Daniels, R; Fuchs, K; Kneilling, M; Neveu, MA; Pichler, BJ; Schmid, AM; Schwenck, J, 2020) |
| " In addition, proper siRNA dosing seems to be important for a positive therapeutic outcome in vivo." | 1.38 | MRI-assessed therapeutic effects of locally administered PLGA nanoparticles loaded with anti-inflammatory siRNA in a murine arthritis model. ( Colombo, S; Foged, C; Jensen, LB; Lammers, T; Nicolay, K; Nielsen, HM; Schiffelers, RM; Storm, G; Strijkers, GJ; te Boekhorst, BC; Varkouhi, AK, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (13.16) | 18.7374 |
| 1990's | 4 (10.53) | 18.2507 |
| 2000's | 6 (15.79) | 29.6817 |
| 2010's | 16 (42.11) | 24.3611 |
| 2020's | 7 (18.42) | 2.80 |
| Authors | Studies |
|---|---|
| Yi, O | 1 |
| Lin, Y | 1 |
| Hu, M | 1 |
| Hu, S | 1 |
| Su, Z | 1 |
| Liao, J | 1 |
| Liu, B | 1 |
| Liu, L | 1 |
| Cai, X | 1 |
| Wang, Q | 1 |
| Asenso, J | 1 |
| Xiao, N | 1 |
| Gao, J | 1 |
| Xiao, F | 1 |
| Kuai, J | 1 |
| Wei, W | 1 |
| Wang, C | 1 |
| Pucino, V | 2 |
| Nefla, M | 1 |
| Gauthier, V | 1 |
| Alsaleh, G | 1 |
| Clayton, SA | 1 |
| Marshall, J | 1 |
| Filer, A | 1 |
| Clark, AR | 1 |
| Raza, K | 1 |
| Buckley, CD | 1 |
| Rodríguez-Muguruza, S | 1 |
| Altuna-Coy, A | 1 |
| Arreaza-Gil, V | 1 |
| Mendieta-Homs, M | 1 |
| Castro-Oreiro, S | 1 |
| Poveda-Elices, MJ | 1 |
| Del Castillo-Piñol, N | 1 |
| Fontova-Garrofé, R | 1 |
| Chacón, MR | 1 |
| Mueller, C | 1 |
| Lin, JC | 1 |
| Thannickal, HH | 1 |
| Daredia, A | 1 |
| Denney, TS | 1 |
| Beyers, R | 1 |
| Younger, JW | 1 |
| Souto-Carneiro, M | 1 |
| Tóth, L | 1 |
| Behnisch, R | 1 |
| Urbach, K | 1 |
| Klika, KD | 1 |
| Carvalho, RA | 1 |
| Lorenz, HM | 1 |
| Neveu, MA | 1 |
| Beziere, N | 1 |
| Daniels, R | 1 |
| Bouzin, C | 1 |
| Comment, A | 1 |
| Schwenck, J | 1 |
| Fuchs, K | 1 |
| Kneilling, M | 1 |
| Pichler, BJ | 1 |
| Schmid, AM | 1 |
| Zhao, J | 1 |
| Zhang, X | 2 |
| Sun, X | 1 |
| Zhao, M | 1 |
| Yu, C | 1 |
| Lee, RJ | 1 |
| Sun, F | 1 |
| Zhou, Y | 1 |
| Li, Y | 1 |
| Teng, L | 1 |
| Yang, Z | 1 |
| Matteson, EL | 1 |
| Goronzy, JJ | 1 |
| Weyand, CM | 1 |
| Yang, XY | 1 |
| Zheng, KD | 1 |
| Lin, K | 1 |
| Zheng, G | 1 |
| Zou, H | 1 |
| Wang, JM | 1 |
| Lin, YY | 1 |
| Chuka, CM | 1 |
| Ge, RS | 1 |
| Zhai, W | 1 |
| Wang, JG | 1 |
| Haas, R | 1 |
| Smith, J | 1 |
| Rocher-Ros, V | 1 |
| Nadkarni, S | 1 |
| Montero-Melendez, T | 1 |
| D'Acquisto, F | 1 |
| Bland, EJ | 1 |
| Bombardieri, M | 2 |
| Pitzalis, C | 2 |
| Perretti, M | 1 |
| Marelli-Berg, FM | 1 |
| Mauro, C | 2 |
| He, J | 1 |
| Li, H | 1 |
| Liu, C | 1 |
| Wang, G | 1 |
| Ge, L | 1 |
| Ma, S | 1 |
| Huang, L | 1 |
| Yan, S | 1 |
| Xu, X | 1 |
| Fujii, W | 1 |
| Kawahito, Y | 1 |
| Nagahara, H | 1 |
| Kukida, Y | 1 |
| Seno, T | 1 |
| Yamamoto, A | 1 |
| Kohno, M | 1 |
| Oda, R | 1 |
| Taniguchi, D | 1 |
| Fujiwara, H | 1 |
| Ejima, A | 1 |
| Kishida, T | 1 |
| Mazda, O | 1 |
| Ashihara, E | 1 |
| Biniecka, M | 1 |
| Canavan, M | 1 |
| McGarry, T | 1 |
| Gao, W | 1 |
| McCormick, J | 1 |
| Cregan, S | 1 |
| Gallagher, L | 1 |
| Smith, T | 1 |
| Phelan, JJ | 1 |
| Ryan, J | 1 |
| O'Sullivan, J | 1 |
| Ng, CT | 1 |
| Veale, DJ | 1 |
| Fearon, U | 1 |
| Sonomoto, K | 1 |
| Yamaoka, K | 1 |
| Kaneko, H | 1 |
| Yamagata, K | 1 |
| Sakata, K | 1 |
| Kondo, M | 1 |
| Zenke, Y | 1 |
| Sabanai, K | 1 |
| Nakayamada, S | 1 |
| Sakai, A | 1 |
| Tanaka, Y | 1 |
| Tang, Q | 1 |
| Cui, J | 1 |
| Tian, Z | 1 |
| Sun, J | 1 |
| Wang, Z | 1 |
| Chang, S | 1 |
| Zhu, S | 1 |
| Belova, SV | 1 |
| Kariakina, EV | 1 |
| Hitchon, CA | 1 |
| El-Gabalawy, HS | 1 |
| Bezabeh, T | 1 |
| Chang, X | 1 |
| Wei, C | 1 |
| Scheinman, RI | 1 |
| Trivedi, R | 1 |
| Vermillion, S | 1 |
| Kompella, UB | 1 |
| Tiihonen, RP | 1 |
| Skyttä, ET | 2 |
| Kaarela, K | 1 |
| Ikävalko, M | 2 |
| Belt, EA | 2 |
| te Boekhorst, BC | 1 |
| Jensen, LB | 1 |
| Colombo, S | 1 |
| Varkouhi, AK | 1 |
| Schiffelers, RM | 1 |
| Lammers, T | 1 |
| Storm, G | 1 |
| Nielsen, HM | 1 |
| Strijkers, GJ | 1 |
| Foged, C | 1 |
| Nicolay, K | 1 |
| Park, JS | 2 |
| Yang, HN | 1 |
| Jeon, SY | 1 |
| Woo, DG | 1 |
| Kim, MS | 1 |
| Park, KH | 1 |
| Présumey, J | 1 |
| Salzano, G | 1 |
| Courties, G | 1 |
| Shires, M | 1 |
| Ponchel, F | 1 |
| Jorgensen, C | 1 |
| Apparailly, F | 1 |
| De Rosa, G | 1 |
| KALLIOMAKI, JL | 1 |
| PULKKINEN, M | 1 |
| SAVOLA, P | 1 |
| Mavridis, AK | 1 |
| Drosos, AA | 1 |
| Tsolas, O | 1 |
| Moutsopoulos, HM | 1 |
| Gobelet, C | 1 |
| Gerster, JC | 1 |
| Brothers, GB | 1 |
| Hadler, NM | 1 |
| Naughton, D | 1 |
| Whelan, M | 1 |
| Smith, EC | 1 |
| Williams, R | 1 |
| Blake, DR | 1 |
| Grootveld, M | 1 |
| Voche, P | 1 |
| Merle, M | 1 |
| Membre, H | 1 |
| Fockens, W | 1 |
| D'Souza, M | 1 |
| DeSouza, P | 1 |
| Meshitsuka, S | 1 |
| Yamazaki, E | 1 |
| Inoue, M | 1 |
| Hagino, H | 1 |
| Teshima, R | 1 |
| Yamamoto, K | 1 |
| Voutilainen, N | 1 |
| Pätiälä, H | 1 |
| Juutilainen, T | 1 |
| Partio, EK | 1 |
| Rokkanen, P | 1 |
| Adcocks, C | 1 |
| Collin, P | 1 |
| Buttle, DJ | 1 |
| Kim, WU | 1 |
| Lee, WK | 1 |
| Ryoo, JW | 1 |
| Kim, SH | 1 |
| Kim, J | 1 |
| Youn, J | 1 |
| Min, SY | 1 |
| Bae, EY | 1 |
| Hwang, SY | 1 |
| Park, SH | 1 |
| Cho, CS | 1 |
| Kim, HY | 1 |
| Evanchick, CE | 1 |
| Davis, DE | 1 |
| Harrington, TM | 1 |
5 reviews available for lactic acid and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Lactate metabolism in rheumatoid arthritis: Pathogenic mechanisms and therapeutic intervention with natural compounds.
Topics: Arthritis, Rheumatoid; Fibroblasts; Humans; Inflammation; Lactic Acid; Synovial Membrane | 2022 |
Lactic Acid Regulation: A Potential Therapeutic Option in Rheumatoid Arthritis.
Topics: Animals; Arthritis, Rheumatoid; Interleukins; Joints; Lactic Acid; Synoviocytes | 2022 |
T-cell metabolism in autoimmune disease.
Topics: Adenosine Triphosphate; Arthritis, Rheumatoid; Autoimmune Diseases; Humans; Lactic Acid; Lupus Eryth | 2015 |
Lactate at the crossroads of metabolism, inflammation, and autoimmunity.
Topics: Animals; Arthritis, Rheumatoid; Autoimmune Diseases; Autoimmunity; Energy Metabolism; Humans; Immune | 2017 |
Glycolysis and rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Autoantigens; Cell Differentiation; Cell Proliferation; Fructose-Bisphosphate | 2011 |
1 trial available for lactic acid and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Reconstruction of the trapeziometacarpal joint in inflammatory joint disease using interposition of autologous tendon or poly-L-D-lactic acid implants: a prospective clinical trial.
Topics: Absorbable Implants; Adult; Aged; Arthritis, Rheumatoid; Arthroplasty; Bioprosthesis; Carpometacarpa | 2012 |
32 other studies available for lactic acid and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Differential effect of lactate on synovial fibroblast and macrophage effector functions.
Topics: Arthritis, Rheumatoid; Fibroblasts; Humans; Inflammation; Interleukin-6; Lactic Acid | 2023 |
A serum metabolic biomarker panel for early rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Biomarkers; Glyceric Acids; Humans; Lactic Acid | 2023 |
No evidence of abnormal metabolic or inflammatory activity in the brains of patients with rheumatoid arthritis: results from a preliminary study using whole-brain magnetic resonance spectroscopic imaging (MRSI).
Topics: Adult; Arthritis, Rheumatoid; Brain; Case-Control Studies; Choline; Female; Humans; Inositol; Lactic | 2020 |
Differences in the serum metabolome and lipidome identify potential biomarkers for seronegative rheumatoid arthritis versus psoriatic arthritis.
Topics: Acetates; Adult; Aged; Aged, 80 and over; Alanine; Amino Acids; Arthritis, Psoriatic; Arthritis, Rhe | 2020 |
Lactate Production Precedes Inflammatory Cell Recruitment in Arthritic Ankles: an Imaging Study.
Topics: Animals; Ankle; Arthritis, Rheumatoid; Carbon Isotopes; Female; Fluorine; Inflammation; Joints; Lact | 2020 |
Dual-functional lipid polymeric hybrid pH-responsive nanoparticles decorated with cell penetrating peptide and folate for therapy against rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arginine; Arthritis, Experimental; Arthritis, Rheumatoid; Cell-Penetr | 2018 |
Energy Metabolism Disorder as a Contributing Factor of Rheumatoid Arthritis: A Comparative Proteomic and Metabolomic Study.
Topics: Adult; Arthritis, Rheumatoid; Biomarkers; Energy Metabolism; Female; Glucose; Humans; Knee Joint; La | 2015 |
Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions.
Topics: Animals; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; Cell Movement; Chemokines; Female; Glyco | 2015 |
Formulation and evaluation of poly(lactic-co-glycolic acid) microspheres loaded with an altered collagen type II peptide for the treatment of rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Collagen Type II; Drug Deliver | 2015 |
Monocarboxylate transporter 4, associated with the acidification of synovial fluid, is a novel therapeutic target for inflammatory arthritis.
Topics: Aged; Animals; Apoptosis; Arthritis, Experimental; Arthritis, Rheumatoid; Cartilage, Articular; Fema | 2015 |
Dysregulated bioenergetics: a key regulator of joint inflammation.
Topics: Amino Acids, Dicarboxylic; Arthritis, Rheumatoid; Cell Movement; Cells, Cultured; Cytokines; DNA, Mi | 2016 |
Spontaneous Differentiation of Human Mesenchymal Stem Cells on Poly-Lactic-Co-Glycolic Acid Nano-Fiber Scaffold.
Topics: Arthritis, Rheumatoid; Biocompatible Materials; Blotting, Western; Case-Control Studies; Cell Differ | 2016 |
Oxygen and indocyanine green loaded phase-transition nanoparticle-mediated photo-sonodynamic cytotoxic effects on rheumatoid arthritis fibroblast-like synoviocytes.
Topics: Apoptosis; Arthritis, Rheumatoid; Biocompatible Materials; Cell Survival; Drug Delivery Systems; Fib | 2017 |
[Condition of oxidation homeostasis and possibility of its correction in experimental rheumatoid arthritis].
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Ceruloplasmin; Homeostasis; Hydrogen Peroxi | 2008 |
Characterization of synovial tissue from arthritis patients: a proton magnetic resonance spectroscopic investigation.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Case-Control Studies; Choline; Creatine; Fuco | 2009 |
Functionalized STAT1 siRNA nanoparticles regress rheumatoid arthritis in a mouse model.
Topics: Animals; Arthritis, Rheumatoid; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Drug S | 2011 |
MRI-assessed therapeutic effects of locally administered PLGA nanoparticles loaded with anti-inflammatory siRNA in a murine arthritis model.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Bone Marrow; Cell Line; Drug Carriers; Fatt | 2012 |
The use of anti-COX2 siRNA coated onto PLGA nanoparticles loading dexamethasone in the treatment of rheumatoid arthritis.
Topics: Apoptosis; Arthritis, Rheumatoid; Caspase 3; Cell Line; Cell Survival; Cyclooxygenase 2; Dexamethaso | 2012 |
PLGA microspheres encapsulating siRNA anti-TNFalpha: efficient RNAi-mediated treatment of arthritic joints.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Line; Drug Design; Lactic Acid; Mice; | 2012 |
Lactic acid response to muscular exercise in rheumatoid arthritis.
Topics: Arthritis; Arthritis, Rheumatoid; Exercise; Humans; Lactic Acid; Muscles | 1957 |
One-year results of use of poly-L/D-lactic acid joint scaffolds and bone packing in revision metacarpophalangeal arthroplasty.
Topics: Absorbable Implants; Adult; Aged; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; | 2007 |
Lactate levels in Brucella arthritis.
Topics: Arthritis; Arthritis, Infectious; Arthritis, Rheumatoid; Brucellosis; Gout; Humans; Lactates; Lactic | 1984 |
Synovial fluid lactate levels in septic and non-septic arthritides.
Topics: Arthritis; Arthritis, Infectious; Arthritis, Reactive; Arthritis, Rheumatoid; Gonorrhea; Hemarthrosi | 1984 |
Diurnal variations in rheumatoid synovial effusions.
Topics: Adult; Arthritis, Rheumatoid; Circadian Rhythm; Female; Glucose; Humans; Hydrogen-Ion Concentration; | 1983 |
An investigation of the abnormal metabolic status of synovial fluid from patients with rheumatoid arthritis by high field proton nuclear magnetic resonance spectroscopy.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Arthritis, Rheumatoid; Blood Glucose; Chylomicrons; Glucose; Hum | 1993 |
Bioabsorbable rods and pins for fixation of metacarpophalangeal arthrodesis of the thumb.
Topics: Adolescent; Adult; Aged; Animals; Arthritis, Rheumatoid; Arthrodesis; Female; Femur; Follow-Up Studi | 1995 |
Preparation and testing of cyclosporine microsphere and solution formulations in the treatment of polyarthritis in rats.
Topics: Animals; Arthritis, Rheumatoid; Cell Division; Cells, Cultured; Chemistry, Pharmaceutical; Cyclospor | 1998 |
Nuclear magnetic resonance studies of synovial fluids from patients with rheumatoid arthritis and osteoarthritis.
Topics: Alanine; Arthritis, Rheumatoid; Biomarkers; Diagnosis, Differential; Female; Humans; Lactic Acid; Ma | 1999 |
Long-term results of ankle and triple arthrodeses fixed with self-reinforced polylevolactic acid implants in patients with rheumatoid arthritis.
Topics: Absorbable Implants; Adult; Aged; Ankle Joint; Arthritis, Rheumatoid; Arthrodesis; Biocompatible Mat | 2001 |
Catechins from green tea (Camellia sinensis) inhibit bovine and human cartilage proteoglycan and type II collagen degradation in vitro.
Topics: Animals; Arthritis, Rheumatoid; Cartilage; Cartilage, Articular; Catechin; Cattle; Collagen Type II; | 2002 |
Suppression of collagen-induced arthritis by single administration of poly(lactic-co-glycolic acid) nanoparticles entrapping type II collagen: a novel treatment strategy for induction of oral tolerance.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoimmunity; Biocompatible Materials; Catt | 2002 |
Septic arthritis. Clinical approach to the 'hot joint'.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Arthritis, Infectious; Arthritis, Rheumatoid; Child; Diagn | 1986 |