lactic acid has been researched along with Arthritis, Degenerative in 40 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In previous work, we reported on the design of biodegradable rhein-loaded PLGA microparticles for the treatment of osteoarthritis." | 8.31 | Evaluation of the Effects of Gamma Radiation Sterilization on Rhein-Loaded Biodegradable Microparticles for the Treatment of Osteoarthritis. ( Avendaño-Godoy, J; Gómez-Gaete, C; Poblete, MG; Ramos, RG, 2023) |
| "Sulforaphane (SFN) is a member of the isothiocyanate family that has anti-inflammatory action as well as anti-carcinogenic properties." | 5.39 | Sulforaphane-PLGA microspheres for the intra-articular treatment of osteoarthritis. ( Choi, YJ; Im, GI; Jeong, GJ; Ko, JY, 2013) |
| "In previous work, we reported on the design of biodegradable rhein-loaded PLGA microparticles for the treatment of osteoarthritis." | 4.31 | Evaluation of the Effects of Gamma Radiation Sterilization on Rhein-Loaded Biodegradable Microparticles for the Treatment of Osteoarthritis. ( Avendaño-Godoy, J; Gómez-Gaete, C; Poblete, MG; Ramos, RG, 2023) |
| "In 2011, we reported good results after a mean follow-up of 14 months for a series of 25 patients who underwent thumb carpometacarpal osteoarthritis surgery in which a poly-L-lactic acid implant was interposed arthroscopically." | 3.81 | Arthroscopic interposition in thumb carpometacarpal osteoarthritis: A series of 26 cases. ( Facca, S; Gouzou, S; Hendriks, S; Ichihara, S; Liverneaux, P; Pereira, A, 2015) |
| ": To examine whether lidocaine cytotoxicity to chondrocytes has been implicated in the development of osteoarthritis of the zygapophysial joints." | 3.75 | Lidocaine cytotoxicity to the zygapophysial joints in rabbits: changes in cell viability and proteoglycan metabolism in vitro. ( Baba, H; Kobayashi, S; Kubota, M; Meir, A; Miyazaki, T; Shimada, S; Takeno, K; Urban, J, 2009) |
| "Osteoarthritis is a severe and debilitating joint disease, which is characterized as results from damage and degeneration of the articular cartilage of the joint surfaces." | 1.48 | Development of Targeted Nanoscale Drug Delivery System for Osteoarthritic Cartilage Tissue. ( Carbone, EJ; Jiang, T; Kan, HM; Li, Y; Lo, KW; Rajpura, K, 2018) |
| "Lactic acid is a widely used substrate for polymers synthesis, PLGA and PLLA in particular." | 1.43 | The effects of lactate and acid on articular chondrocytes function: Implications for polymeric cartilage scaffold design. ( Chen, Y; Coen, ND; Dai, J; Heng, BC; Ouyang, H; Pan, Z; Sun, H; Tian, N; Wang, J; Wu, Y; Xu, H; Yu, D; Zhang, X; Zhu, S, 2016) |
| "Sulforaphane (SFN) is a member of the isothiocyanate family that has anti-inflammatory action as well as anti-carcinogenic properties." | 1.39 | Sulforaphane-PLGA microspheres for the intra-articular treatment of osteoarthritis. ( Choi, YJ; Im, GI; Jeong, GJ; Ko, JY, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (20.00) | 18.7374 |
| 1990's | 4 (10.00) | 18.2507 |
| 2000's | 7 (17.50) | 29.6817 |
| 2010's | 16 (40.00) | 24.3611 |
| 2020's | 5 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Avendaño-Godoy, J | 1 |
| Poblete, MG | 1 |
| Ramos, RG | 1 |
| Gómez-Gaete, C | 1 |
| Huang, YF | 1 |
| Wang, G | 1 |
| Ding, L | 1 |
| Bai, ZR | 1 |
| Leng, Y | 1 |
| Tian, JW | 1 |
| Zhang, JZ | 1 |
| Li, YQ | 1 |
| Qin, YH | 1 |
| Li, X | 1 |
| Qi, X | 1 |
| Marcuzzi, A | 1 |
| Colzani, G | 1 |
| Acciaro, AL | 1 |
| Rosa, ND | 1 |
| Landi, A | 1 |
| Salgado, C | 1 |
| Guénée, L | 1 |
| Černý, R | 1 |
| Allémann, E | 1 |
| Jordan, O | 1 |
| de Bakker, E | 1 |
| Broeckx, B | 1 |
| Demeyere, K | 1 |
| Stroobants, V | 1 |
| Van Ryssen, B | 1 |
| Meyer, E | 1 |
| Jiang, T | 2 |
| Kan, HM | 1 |
| Rajpura, K | 1 |
| Carbone, EJ | 1 |
| Li, Y | 1 |
| Lo, KW | 1 |
| Bulysheva, AA | 1 |
| Sori, N | 1 |
| Francis, MP | 1 |
| Ko, JY | 1 |
| Choi, YJ | 1 |
| Jeong, GJ | 1 |
| Im, GI | 1 |
| Guinet, V | 1 |
| Mure, JP | 1 |
| Vimont, E | 1 |
| Semere, A | 1 |
| Forli, A | 1 |
| Corcella, D | 1 |
| Mesquida, V | 1 |
| Loret, MG | 1 |
| Moutet, F | 1 |
| de Andrés, MC | 1 |
| Maneiro, E | 1 |
| Martín, MA | 1 |
| Arenas, J | 1 |
| Blanco, FJ | 2 |
| Magalhães, J | 1 |
| Lebourg, M | 1 |
| Deplaine, H | 1 |
| Gómez Ribelles, JL | 1 |
| Proot, JL | 1 |
| de Vicente, F | 1 |
| Sheahan, DE | 1 |
| Riffault, M | 1 |
| Six, JL | 1 |
| Netter, P | 1 |
| Gillet, P | 1 |
| Grossin, L | 1 |
| Pereira, A | 1 |
| Ichihara, S | 1 |
| Facca, S | 1 |
| Hendriks, S | 1 |
| Gouzou, S | 1 |
| Liverneaux, P | 1 |
| Morille, M | 1 |
| Toupet, K | 1 |
| Montero-Menei, CN | 1 |
| Jorgensen, C | 1 |
| Noël, D | 1 |
| Sonomoto, K | 1 |
| Yamaoka, K | 1 |
| Kaneko, H | 1 |
| Yamagata, K | 1 |
| Sakata, K | 1 |
| Zhang, X | 2 |
| Kondo, M | 1 |
| Zenke, Y | 1 |
| Sabanai, K | 1 |
| Nakayamada, S | 1 |
| Sakai, A | 1 |
| Tanaka, Y | 1 |
| Wu, Y | 1 |
| Pan, Z | 1 |
| Sun, H | 1 |
| Wang, J | 1 |
| Yu, D | 1 |
| Zhu, S | 1 |
| Dai, J | 1 |
| Chen, Y | 1 |
| Tian, N | 1 |
| Heng, BC | 1 |
| Coen, ND | 1 |
| Xu, H | 1 |
| Ouyang, H | 1 |
| Goto, N | 1 |
| Okazaki, K | 1 |
| Akasaki, Y | 1 |
| Ishihara, K | 1 |
| Murakami, K | 1 |
| Koyano, K | 1 |
| Ayukawa, Y | 1 |
| Yasunami, N | 1 |
| Masuzaki, T | 1 |
| Nakashima, Y | 1 |
| NICHOLSON, DP | 1 |
| Zainal, Z | 1 |
| Longman, AJ | 1 |
| Hurst, S | 1 |
| Duggan, K | 1 |
| Caterson, B | 1 |
| Hughes, CE | 1 |
| Harwood, JL | 1 |
| Takeno, K | 1 |
| Kobayashi, S | 1 |
| Miyazaki, T | 1 |
| Shimada, S | 1 |
| Kubota, M | 1 |
| Meir, A | 1 |
| Urban, J | 1 |
| Baba, H | 1 |
| Ramakrishnan, P | 1 |
| Hecht, BA | 1 |
| Pedersen, DR | 2 |
| Lavery, MR | 1 |
| Maynard, J | 1 |
| Buckwalter, JA | 2 |
| Martin, JA | 2 |
| MAWSON, R | 1 |
| Petersen, RR | 1 |
| Call, G | 1 |
| Ofek, G | 1 |
| Gao, J | 1 |
| Yao, JQ | 1 |
| Sherwood, JK | 1 |
| Riley, SL | 1 |
| Palazzolo, R | 1 |
| Brown, SC | 1 |
| Monkhouse, DC | 1 |
| Coates, M | 1 |
| Griffith, LG | 1 |
| Landeen, LK | 1 |
| Ratcliffe, A | 1 |
| LAWRENCE, JS | 1 |
| WAUGH, WG | 1 |
| De Mattei, M | 1 |
| Pasello, M | 1 |
| Pellati, A | 1 |
| Stabellini, G | 1 |
| Massari, L | 1 |
| Gemmati, D | 1 |
| Caruso, A | 1 |
| SØNDER, P | 1 |
| Beecher, BR | 1 |
| Heiner, AD | 1 |
| Mavridis, AK | 1 |
| Drosos, AA | 1 |
| Tsolas, O | 1 |
| Moutsopoulos, HM | 1 |
| Gobelet, C | 1 |
| Gerster, JC | 1 |
| Voche, P | 1 |
| Merle, M | 1 |
| Membre, H | 1 |
| Fockens, W | 1 |
| Mainil-Varlet, P | 1 |
| Cordey, J | 1 |
| Landolt, M | 1 |
| Gogolewski, S | 1 |
| Böstman, OM | 1 |
| Meshitsuka, S | 1 |
| Yamazaki, E | 1 |
| Inoue, M | 1 |
| Hagino, H | 1 |
| Teshima, R | 1 |
| Yamamoto, K | 1 |
| Borderie, D | 1 |
| Le Marechal, H | 1 |
| Ekindjian, OG | 1 |
| Hernvann, A | 1 |
| Adcocks, C | 1 |
| Collin, P | 1 |
| Buttle, DJ | 1 |
| Ahrengart, L | 1 |
| Sahlin, K | 1 |
| Lindgren, U | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PEMFS in Patients With CRPS-I of the Foot and Ankle: a Randomized Controlled Trial[NCT05922618] | 28 participants (Anticipated) | Interventional | 2023-08-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
40 other studies available for lactic acid and Arthritis, Degenerative
| Article | Year |
|---|---|
Evaluation of the Effects of Gamma Radiation Sterilization on Rhein-Loaded Biodegradable Microparticles for the Treatment of Osteoarthritis.
Topics: Gamma Rays; Humans; Lactic Acid; Microspheres; Osteoarthritis; Particle Size; Polyglycolic Acid; Pol | 2023 |
Lactate-upregulated NADPH-dependent NOX4 expression via HCAR1/PI3K pathway contributes to ROS-induced osteoarthritis chondrocyte damage.
Topics: Animals; Cells, Cultured; Chondrocytes; Humans; Lactic Acid; NADP; NADPH Oxidase 4; Osteoarthritis; | 2023 |
Retrospective Review of Long-term Outcomes of Patients Undergoing CMC Arthroplasty With Interposition Scaffold.
Topics: Arthroplasty; Carpometacarpal Joints; Humans; Lactic Acid; Osteoarthritis; Retrospective Studies; Tr | 2022 |
Nano wet milled celecoxib extended release microparticles for local management of chronic inflammation.
Topics: Celecoxib; Drug Liberation; Humans; Inflammation; Lactic Acid; Osteoarthritis; Particle Size | 2020 |
Detection of osteoarthritis in dogs by metabolic, pro-inflammatory and degenerative synovial fluid biomarkers and traditional radiographic screening: A pilot study.
Topics: Animals; Biomarkers; Dog Diseases; Dogs; Female; Glucose; Hydrogen-Ion Concentration; Immunoassay; I | 2021 |
Development of Targeted Nanoscale Drug Delivery System for Osteoarthritic Cartilage Tissue.
Topics: Cartilage; Drug Carriers; Drug Delivery Systems; Humans; Lactic Acid; Nanoparticles; Osteoarthritis; | 2018 |
Direct crystal formation from micronized bone and lactic acid: The writing on the wall for calcium-containing crystal pathogenesis in osteoarthritis?
Topics: Aged; Aged, 80 and over; Bone and Bones; Calcium; Calcium Oxalate; Calcium Pyrophosphate; Crystalliz | 2018 |
Sulforaphane-PLGA microspheres for the intra-articular treatment of osteoarthritis.
Topics: Aged; Animals; Cartilage, Articular; Chondrocytes; Cytoprotection; Dose-Response Relationship, Drug; | 2013 |
[Clinical and radiologic evaluation of a polylactic acid interposition arthroplasty after trapezectomy].
Topics: Aged; Aged, 80 and over; Arthroplasty; Arthroscopy; Biocompatible Materials; Carpometacarpal Joints; | 2013 |
[Foreign body reaction in osteoarthritis of the trapeziometacarpal joint treated by trapezectomy and interposition of a L-polylactic acid "anchovy" (Arex®615R). A series of eight cases].
Topics: Adult; Aged, 80 and over; Arthroplasty; Arthroscopy; Biocompatible Materials; Carpometacarpal Joints | 2013 |
Nitric oxide compounds have different effects profiles on human articular chondrocyte metabolism.
Topics: Adenosine Triphosphate; Adult; Aged; Aged, 80 and over; Apoptosis; Cartilage, Articular; Cells, Cult | 2013 |
Effect of the physicochemical properties of pure or chitosan-coated poly(L-lactic acid)scaffolds on the chondrogenic differentiation of mesenchymal stem cells from osteoarthritic patients.
Topics: Adsorption; Cell Differentiation; Cell Proliferation; Cell Survival; Cellular Microenvironment; Chit | 2015 |
Analysis of lactate concentrations in canine synovial fluid.
Topics: Animals; Arthritis; Arthritis, Infectious; Case-Control Studies; Cell Count; Dog Diseases; Dogs; Fem | 2015 |
PLGA-Based Nanoparticles: a Safe and Suitable Delivery Platform for Osteoarticular Pathologies.
Topics: Adipogenesis; Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chondrogenesis; Dr | 2015 |
Arthroscopic interposition in thumb carpometacarpal osteoarthritis: A series of 26 cases.
Topics: Adult; Aged; Aged, 80 and over; Arthroplasty, Replacement; Arthroscopy; Carpometacarpal Joints; Disa | 2015 |
PLGA-based microcarriers induce mesenchymal stem cell chondrogenesis and stimulate cartilage repair in osteoarthritis.
Topics: Animals; Cartilage, Articular; Cells, Cultured; Chondrogenesis; Drug Carriers; Humans; Knee Joint; L | 2016 |
Spontaneous Differentiation of Human Mesenchymal Stem Cells on Poly-Lactic-Co-Glycolic Acid Nano-Fiber Scaffold.
Topics: Arthritis, Rheumatoid; Biocompatible Materials; Blotting, Western; Case-Control Studies; Cell Differ | 2016 |
The effects of lactate and acid on articular chondrocytes function: Implications for polymeric cartilage scaffold design.
Topics: Cartilage, Articular; Cell Proliferation; Chondrocytes; Extracellular Matrix; Gene Expression Profil | 2016 |
Single intra-articular injection of fluvastatin-PLGA microspheres reduces cartilage degradation in rabbits with experimental osteoarthritis.
Topics: Animals; Anticholesteremic Agents; Arthritis, Experimental; Cartilage, Articular; Chondrocytes; Drug | 2017 |
The treatment of osteo-arthritis with procaine lactic acid.
Topics: Arthritis; Lactic Acid; Osteoarthritis; Procaine | 1948 |
Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis.
Topics: ADAM Proteins; Animals; Carpus, Animal; Cartilage, Articular; Cattle; Cells, Cultured; Chondrocytes; | 2009 |
Lidocaine cytotoxicity to the zygapophysial joints in rabbits: changes in cell viability and proteoglycan metabolism in vitro.
Topics: Analysis of Variance; Animals; Cartilage, Articular; Cell Count; Cell Survival; Cells, Cultured; Cho | 2009 |
Oxidant conditioning protects cartilage from mechanically induced damage.
Topics: Adaptation, Physiological; Aggrecans; Animals; Apoptosis; Cartilage, Articular; Catalase; Cell Survi | 2010 |
Treatment of osteoarthritis by lactic acid injection; a series of 26 consecutive cases in general practice.
Topics: General Practice; Humans; Injections; Lactic Acid; Osteoarthritis | 1946 |
Development of chondroitin sulfate encapsulated PLGA microsphere delivery systems with controllable multiple burst releases for treating osteoarthritis.
Topics: Biocompatible Materials; Chondroitin Sulfates; Drug Compounding; Drug Delivery Systems; Humans; Lact | 2011 |
A three-dimensional osteochondral composite scaffold for articular cartilage repair.
Topics: Analysis of Variance; Biocompatible Materials; Biodegradation, Environmental; Cartilage, Articular; | 2002 |
Lactic acid in the treatment of osteo-arthritis.
Topics: Arthritis; Lactic Acid; Osteoarthritis | 1953 |
Lactic acid in the treatment of osteo-arthritis.
Topics: Arthritis; Lactic Acid; Osteoarthritis | 1953 |
Effects of electromagnetic fields on proteoglycan metabolism of bovine articular cartilage explants.
Topics: Animals; Cartilage, Articular; Cattle; Culture Techniques; Down-Regulation; Electromagnetic Fields; | 2003 |
[Lactic acid therapy of arthrosis].
Topics: Arthritis; Humans; Joint Diseases; Lactic Acid; Osteoarthritis | 1950 |
Antioxidants block cyclic loading induced chondrocyte death.
Topics: Antioxidants; Apoptosis; Cartilage, Articular; Chondrocytes; Humans; In Situ Nick-End Labeling; Lact | 2007 |
Lactate levels in Brucella arthritis.
Topics: Arthritis; Arthritis, Infectious; Arthritis, Rheumatoid; Brucellosis; Gout; Humans; Lactates; Lactic | 1984 |
Synovial fluid lactate levels in septic and non-septic arthritides.
Topics: Arthritis; Arthritis, Infectious; Arthritis, Reactive; Arthritis, Rheumatoid; Gonorrhea; Hemarthrosi | 1984 |
Bioabsorbable rods and pins for fixation of metacarpophalangeal arthrodesis of the thumb.
Topics: Adolescent; Adult; Aged; Animals; Arthritis, Rheumatoid; Arthrodesis; Female; Femur; Follow-Up Studi | 1995 |
The use of a resorbable augmentation device to secure plating of osteoporotic bones. An in vitro study.
Topics: Bone Cements; Bone Plates; Fracture Fixation, Internal; Fractures, Bone; Humans; In Vitro Techniques | 1997 |
Osteoarthritis of the ankle after foreign-body reaction to absorbable pins and screws: a three- to nine-year follow-up study.
Topics: Absorption; Adult; Ankle Joint; Biocompatible Materials; Bone Nails; Bone Screws; Chi-Square Distrib | 1998 |
Nuclear magnetic resonance studies of synovial fluids from patients with rheumatoid arthritis and osteoarthritis.
Topics: Alanine; Arthritis, Rheumatoid; Biomarkers; Diagnosis, Differential; Female; Humans; Lactic Acid; Ma | 1999 |
Nitric oxide modifies glycolytic pathways in cultured human synoviocytes.
Topics: Cell Survival; Cells, Cultured; Deoxyglucose; Dose-Response Relationship, Drug; Glucose; Glyceraldeh | 2000 |
Catechins from green tea (Camellia sinensis) inhibit bovine and human cartilage proteoglycan and type II collagen degradation in vitro.
Topics: Animals; Arthritis, Rheumatoid; Cartilage; Cartilage, Articular; Catechin; Cattle; Collagen Type II; | 2002 |
Myositis ossificans after total hip replacement and perioperative muscle ischemia.
Topics: Aged; Aged, 80 and over; Female; Hip Prosthesis; Humans; Ischemia; Lactates; Lactic Acid; Male; Midd | 1987 |