Page last updated: 2024-10-17

lactic acid and Apoplexy

lactic acid has been researched along with Apoplexy in 72 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a genetically heterogeneous disorder caused by mitochondrial DNA (mtDNA) mutations in the MT-TL1 gene."8.12Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome. ( Arenas, J; Arranz-Canales, E; Delmiro, A; Domínguez-González, C; González de la Aleja, J; Guerrero-Molina, MP; Martín, MA; Morales-Conejo, M; Morán, M; Ramos-González, A, 2022)
"We here reported the clinical course and therapeutic details of a 16-year-old girl with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) who had had five stroke-like episodes (two episodes were clinically mild, while the three subsequent episodes were severe)."7.72Beneficial effect of L-arginine for stroke-like episode in MELAS. ( Kubota, M; Momoi-Yoshida, M; Mori, M; Sakakihara, Y; Yamagata, T, 2004)
"However, the treatment of stroke using the vast majority of possible drug candidates, including erythropoietin (EPO), remains problematic because of the presence of the blood-brain barrier (BBB), resulting in scarce penetration onto the brain."5.51Protective Effect of Cholic Acid-Coated Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles Loaded with Erythropoietin on Experimental Stroke. ( Han, SY; Jeong, JH; Jeong, YG; Kang, SH; Kim, DK; Lee, NS, 2019)
"The long-term effects of the sodium salt of dichloroacetic acid (DCA) were evaluated in four patients with mitochondrial encephalomyelopathy with lactic acidosis and stroke-like episodes (MELAS) carrying A3243G mutation."5.11Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS. ( Goto, T; Momoi, MY; Mori, M; Saito, S; Yamagata, T, 2004)
" The authors' goal was to characterize patterns of markers of energy metabolism (glucose, pyruvate, and lactate) and neuronal injury (glutamate and glycerol) in patients with subarachnoid hemorrhage (SAH), in whom ischemia was or was not suspected."5.09Cerebral microdialysis monitoring: determination of normal and ischemic cerebral metabolisms in patients with aneurysmal subarachnoid hemorrhage. ( Bjerre, P; Schulz, MK; Tange, M; Wang, LP, 2000)
"We sought to measure the temporal evolution and spatial distribution of lesion macromolecules and small molecules (lactate, N-acetyl compounds, creatine, and choline) in stroke patients by using short echo time in vivo proton MR spectroscopy."5.09Spectroscopic assessment of alterations in macromolecule and small-molecule metabolites in human brain after stroke. ( Graham, GD; Hwang, JH; Prichard, JW; Rothman, DL, 2001)
"Lesional NAA and creatine were significantly lower in subacute than in acute stroke."4.31Predicting the Onset of Ischemic Stroke With Fast High-Resolution 3D MR Spectroscopic Imaging. ( Bo, B; Guan, Y; Guo, R; Li, Y; Liang, ZP; Lin, DJ; Lin, Z; Liu, J; Meng, Z; Nachev, P; Wang, T; Yu, X; Zhao, Y; Zhou, H, 2023)
"Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a genetically heterogeneous disorder caused by mitochondrial DNA (mtDNA) mutations in the MT-TL1 gene."4.12Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome. ( Arenas, J; Arranz-Canales, E; Delmiro, A; Domínguez-González, C; González de la Aleja, J; Guerrero-Molina, MP; Martín, MA; Morales-Conejo, M; Morán, M; Ramos-González, A, 2022)
"To examine the correlation between verbal and visual memory function and correlation with brain metabolites (lactate and N-Acetylaspartate, NAA) in individuals with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)."4.12Visual memory failure presages conversion to MELAS phenotype. ( De Vivo, DC; DiMauro, S; Engelstad, K; Fryer, RH; Gu, Y; Hinton, VJ; Hirano, M; Leaffer, EB; Shungu, DC, 2022)
"Increased levels of lactic acid, pyruvate, and TMAO may be related to the pathophysiological changes in the minor ischaemic stroke population."4.12Related factors based on non-targeted metabolomics methods in minor ischaemic stroke. ( Chen, C; Ding, L; Guo, J; Liu, H; Ma, Y; Qiao, X; Wang, J; Wang, M; Yang, T; Zhao, S, 2022)
"Ischemic stroke is not uncommon in subjects receiving ECMO support with independent risk factor being a pre-ECMO lactic acid greater than 10 mmol/L."3.83Incidence and predictors of ischemic cerebrovascular stroke among patients on extracorporeal membrane oxygenation support. ( Camporesi, EM; Enten, G; Mangar, D; Mirsaeidi, M; Omar, HR; Shumac, J, 2016)
" Here we sought to identify whether the enhanced lactic acidosis and increased expression of monocarboxylate transporters (MCTs) observed after stroke might be attenuated by single and/or combined EtOH and NBO therapies."3.81Reduced cerebral monocarboxylate transporters and lactate levels by ethanol and normobaric oxygen therapy in severe transient and permanent ischemic stroke. ( Brogan, D; Cai, L; Ding, Y; Du, H; Geng, X; Ji, X; Kwiecien, TD; Peng, C; Rafols, JA; Rastogi, R; Singh, S; Sy, CA, 2015)
"A stroke-like episode is a core symptom in mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS)."3.79Transient ischemic attack-like episodes without stroke-like lesions in MELAS. ( Aida, N; Mitani, T; Osaka, H; Tomiyasu, M; Wada, T, 2013)
"To clarify the roles of serial MR spectroscopy (MRS) and continuous arterial spin labeling (CASL) perfusion images for evaluating cerebral lesions in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)."3.76Pathophysiologic evaluation of MELAS strokes by serially quantified MRS and CASL perfusion images. ( Ikawa, M; Kimura, H; Kudo, T; Kuriyama, M; Okazawa, H; Shimizu, Y; Toyooka, M; Tsujikawa, T; Uematsu, H; Yoneda, M, 2010)
"We here reported the clinical course and therapeutic details of a 16-year-old girl with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) who had had five stroke-like episodes (two episodes were clinically mild, while the three subsequent episodes were severe)."3.72Beneficial effect of L-arginine for stroke-like episode in MELAS. ( Kubota, M; Momoi-Yoshida, M; Mori, M; Sakakihara, Y; Yamagata, T, 2004)
"Poststroke hyperglycemia is common and is associated with increased risk of death and dependence, but appropriate management remains uncertain."2.75Randomized, controlled trial of insulin for acute poststroke hyperglycemia. ( Condon, B; Hadley, D; Macfarlane, JA; McCormick, M; McLean, JR; Muir, KW, 2010)
"NAA/choline (Cho) ratios were significantly reduced in both areas of T2 hyperintensity and in surrounding tissue."2.70Spectroscopic data following stroke reveal tissue abnormality beyond the region of T2-weighted hyperintensity. ( Beley, A; Brunotte, F; Demougeot, C; Giroud, M; Marie, C; Rouaud, O; Walker, P, 2002)
"Stroke is the main cause of acquired disability in adults."1.91Pre-stroke exercise does not reduce atrophy in healthy young adult mice. ( Brox, C; Christiansen, CL; Doosje, HL; Geiseler, SJ; Liesz, A; Morland, C; Nguyen, TD; Phan, KD; Tartanoglu, C, 2023)
"Hyperlactatemia was defined as a lactate level of over 2 mmol/L."1.62Admission blood lactate levels of patients diagnosed with cerebrovascular disease effects on short- and long-term mortality risk. ( Ak, R; Cimilli Ozturk, T; Kırkpantur, ED; Sakal, C; Taşçı, A; Ünal Akoğlu, E, 2021)
"However, the treatment of stroke using the vast majority of possible drug candidates, including erythropoietin (EPO), remains problematic because of the presence of the blood-brain barrier (BBB), resulting in scarce penetration onto the brain."1.51Protective Effect of Cholic Acid-Coated Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles Loaded with Erythropoietin on Experimental Stroke. ( Han, SY; Jeong, JH; Jeong, YG; Kang, SH; Kim, DK; Lee, NS, 2019)
"Stroke is a leading cause of disability with no effective regenerative treatment."1.39Bioengineered sequential growth factor delivery stimulates brain tissue regeneration after stroke. ( Cooke, MJ; Morshead, CM; Sachewsky, N; Shoichet, MS; Wang, Y, 2013)
"Embolism is responsible for half of cerebral infarctions, yet few animal models were developed due to the unpredictability of the embolus-induced infarcts."1.37Characterization of the pattern of ischemic stroke induced by artificial particle embolization in the rat brain. ( Kuo, YM; Tsai, MJ; Tsai, YH, 2011)
"It is well known that some mitochondrial disorders are responsible for ischemic cerebral infarction in young patients."1.31Mitochondrial disease and stroke. ( Aguilera, I; Arenas, J; Bautista, J; Campos, Y; Chinchón, I; Fernández-López, O; García-Lozano, R; Gil-Peralta, A; Martínez-Fernández, E, 2001)

Research

Studies (72)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's26 (36.11)29.6817
2010's35 (48.61)24.3611
2020's11 (15.28)2.80

Authors

AuthorsStudies
Guerrero-Molina, MP1
Morales-Conejo, M1
Delmiro, A1
Morán, M1
Domínguez-González, C1
Arranz-Canales, E1
Ramos-González, A1
Arenas, J2
Martín, MA1
González de la Aleja, J1
Leaffer, EB1
De Vivo, DC1
Engelstad, K1
Fryer, RH1
Gu, Y1
Shungu, DC1
Hirano, M1
DiMauro, S1
Hinton, VJ1
Kobayashi, Y1
Karasawa, S1
Ohashi, N1
Yamamoto, K1
Chen, C1
Qiao, X1
Guo, J1
Yang, T1
Wang, M1
Ma, Y1
Zhao, S1
Ding, L1
Liu, H1
Wang, J1
Lin, Z1
Meng, Z1
Wang, T2
Guo, R1
Zhao, Y1
Li, Y2
Bo, B1
Guan, Y1
Liu, J1
Zhou, H1
Yu, X1
Lin, DJ1
Liang, ZP1
Nachev, P1
Geiseler, SJ1
Phan, KD1
Brox, C1
Nguyen, TD1
Tartanoglu, C1
Doosje, HL1
Christiansen, CL1
Liesz, A1
Morland, C1
Kee, CK1
Ngam, PI1
Tan, AP1
Mamouei, M2
Qassem, M2
Budidha, K2
Baishya, N2
Vadgama, P1
Kyriacou, PA1
Hyacinthe, JN1
Buscemi, L1
Lê, TP1
Lepore, M1
Hirt, L1
Mishkovsky, M1
Gue, YX1
Sayers, M1
Whitby, BT1
Kanji, R1
Adatia, K1
Smith, R1
Davies, WR1
Perperoglou, A1
Potpara, TS1
Lip, GYH1
Gorog, DA1
Yamagata, K2
Kyriacou, P1
Sakal, C1
Ak, R1
Taşçı, A1
Kırkpantur, ED1
Ünal Akoğlu, E1
Cimilli Ozturk, T1
Pinczolits, A2
Zdunczyk, A1
Dengler, NF1
Hecht, N2
Kowoll, CM1
Dohmen, C1
Graf, R1
Winkler, MK1
Major, S1
Hartings, JA1
Dreier, JP2
Vajkoczy, P2
Woitzik, J2
Song, Y1
Soh, S1
Shim, JK1
Park, KU1
Kwak, YL1
Deuchar, GA1
Brennan, D1
Holmes, WM1
Shaw, M1
Macrae, IM1
Santosh, C1
Benedicenti, L1
Gianotti, G1
Galban, EM1
Jeong, JH1
Kang, SH1
Kim, DK1
Lee, NS1
Jeong, YG1
Han, SY1
Mitani, T1
Aida, N1
Tomiyasu, M1
Wada, T1
Osaka, H1
Matsushita, K1
Williams, EK1
Mongraw-Chaffin, ML1
Coresh, J1
Schmidt, MI1
Brancati, FL1
Hoogeveen, RC1
Ballantyne, CM1
Young, JH1
Wasser, G1
Wang, Y3
Cooke, MJ2
Sachewsky, N1
Morshead, CM3
Shoichet, MS3
Sandow, N1
Scheel, M1
Drenckhahn, C1
Shemesh, N3
Rosenberg, JT3
Dumez, JN3
Grant, SC3
Frydman, L3
Muniz, JA2
Bivard, A1
Krishnamurthy, V1
Stanwell, P1
Yassi, N1
Spratt, NJ1
Nilsson, M1
Levi, CR1
Davis, S1
Parsons, MW1
dos Reis, MC1
de Andrade, EA1
Borges, AC1
de Souza, DQ1
Lima, FP1
Nicolau, RA1
Andrade, AO1
Lima, MO1
Geng, X3
Sy, CA1
Kwiecien, TD1
Ji, X1
Peng, C3
Rastogi, R1
Cai, L1
Du, H1
Brogan, D1
Singh, S1
Rafols, JA1
Ding, Y3
Lu, Y1
Zhao, H2
Han, B1
Cui, K1
Wang, S1
Tuladhar, A2
Francica, JV1
Bigongiari, A1
Mochizuki, L1
Scapini, KB1
Moraes, OA1
Mostarda, C1
Caperuto, EC1
Irigoyen, MC1
De Angelis, K1
Rodrigues, B1
Omar, HR1
Mirsaeidi, M1
Shumac, J1
Enten, G1
Mangar, D1
Camporesi, EM1
Shen, J1
Huber, M1
Zhao, EY1
Li, F1
Li, X1
Jiménez-Xarrié, E1
Davila, M1
Candiota, AP1
Delgado-Mederos, R1
Ortega-Martorell, S1
Julià-Sapé, M1
Arús, C1
Martí-Fàbregas, J1
van der Zijden, JP1
van Eijsden, P1
de Graaf, RA1
Dijkhuizen, RM1
Brouns, R1
Sheorajpanday, R1
Wauters, A1
De Surgeloose, D1
Mariën, P1
De Deyn, PP1
Lee, JI1
Wittsack, HJ1
Christaras, A1
Miese, FR1
Siebler, M1
van Baalen, A1
Stephani, U1
Rohr, A1
Muñoz Maniega, S1
Cvoro, V3
Chappell, FM1
Armitage, PA3
Marshall, I3
Bastin, ME3
Wardlaw, JM3
Rivers, CS1
Carpenter, TK1
Wartolowska, K2
Farrall, AJ1
Dennis, MS2
Klose, D1
Laprais, M1
Leroux, V1
Siepmann, F1
Deprez, B1
Bordet, R1
Siepmann, J1
Tsujikawa, T1
Yoneda, M1
Shimizu, Y1
Uematsu, H1
Toyooka, M1
Ikawa, M1
Kudo, T1
Okazawa, H1
Kuriyama, M1
Kimura, H1
Karaszewski, B1
Haga, K1
Scholl-Bürgi, S1
Haberlandt, E1
Gotwald, T1
Albrecht, U1
Baumgartner Sigl, S1
Rauchenzauner, M1
Rostásy, K1
Karall, D1
McCormick, M1
Hadley, D1
McLean, JR1
Macfarlane, JA1
Condon, B1
Muir, KW1
Helbok, R1
Kurtz, P1
Schmidt, JM1
Stuart, RM1
Fernandez, L1
Malhotra, R1
Presciutti, M1
Ostapkovich, ND1
Connolly, ES1
Lee, K1
Badjatia, N1
Mayer, SA1
Claassen, J1
Tsai, MJ1
Tsai, YH1
Kuo, YM1
Balaban'ian, VIu1
Solev, IN1
Elizarova, OS1
Garibova, TL1
Litvinova, SA1
Voronina, TA1
Jo, S1
Jeong, T1
Lee, JB1
Jin, YH1
Yoon, J1
Jun, YK1
Park, B1
Tu, J1
A, J1
Wang, G1
Wen, H1
Wang, A1
Di, L1
Cao, B1
Liu, L1
Bible, E1
Qutachi, O1
Chau, DY1
Alexander, MR1
Shakesheff, KM1
Modo, M1
Bender, B1
Bornemann, A1
Reimold, M1
Ernemann, U1
Horger, M1
Caicco, MJ1
Kochanski, R1
Higashida, T1
Hüttemann, M1
Guthikonda, M1
Schäbitz, WR1
Giuffrida, A1
Berger, C1
Aschoff, A1
Schwaninger, M1
Schwab, S1
Piomelli, D1
Nicoli, F1
Lefur, Y1
Denis, B1
Ranjeva, JP1
Confort-Gouny, S1
Cozzone, PJ1
Anderson, RE1
Winnerkvist, A1
Hansson, LO1
Nilsson, O1
Rosengren, L1
Settergren, G1
Vaage, J1
Vial, F1
Serriere, S1
Barantin, L1
Montharu, J1
Nadal-Desbarats, L1
Pourcelot, L1
Seguin, F1
Stengel, A1
Neumann-Haefelin, T1
Singer, OC1
Neumann-Haefelin, C1
Zanella, FE1
Lanfermann, H1
Pilatus, U1
Mori, M2
Yamagata, T2
Goto, T1
Saito, S1
Momoi, MY1
Kubota, M1
Sakakihara, Y1
Momoi-Yoshida, M1
Baslaim, G1
Bashore, J1
Al-Malki, F1
Jamjoom, A1
Chiang, MF1
Chiu, WT1
Lin, FJ1
Thajeb, P1
Huang, CJ1
Tsai, SH1
Singhal, AB1
Ratai, E1
Benner, T1
Vangel, M1
Lee, V1
Koroshetz, WJ1
Schaefer, PW1
Sorensen, AG1
Gonzalez, RG1
Chen, CJ1
Cheng, FC1
Liao, SL1
Chen, WY1
Lin, NN1
Kuo, JS1
Schulz, MK1
Wang, LP1
Tange, M1
Bjerre, P1
Tagami, M1
Ikeda, K1
Noguchi, T1
Yamori, Y1
Nara, Y1
Pearl, PL1
Krasnewich, D1
Martínez-Fernández, E1
Gil-Peralta, A1
García-Lozano, R1
Chinchón, I1
Aguilera, I1
Fernández-López, O1
Campos, Y1
Bautista, J1
Graham, GD1
Hwang, JH1
Rothman, DL1
Prichard, JW1
Demougeot, C1
Walker, P1
Beley, A1
Marie, C1
Rouaud, O1
Giroud, M1
Brunotte, F1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Low Level LASER Therapy on Spasticity and Gait Parameters in Chronic Stroke Patients With Spastic Planter Flexors.[NCT05425225]18 participants (Anticipated)Interventional2022-03-04Recruiting
Clinical Trial of Normobaric Oxygen Therapy in Acute Ischemic Stroke[NCT00414726]Phase 285 participants (Actual)Interventional2007-01-31Terminated (stopped due to Imbalance in deaths favoring control arm; deaths not attributed to treatment by the blinded external medical monitor.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Primary Efficacy Outcome Measure is a Comparison of the Change in National Institutes of Health Stroke Scale (NIHSS) Scores From Baseline to 4 Hours (During Therapy) in the Two Groups.

The NIHSS score ranges from 0 (best score) to 42 (worst score). (NCT00414726)
Timeframe: 4 hours after starting treatment

Intervention0-4 hour change in NIHSS score (Mean)
Normobaric Oxygen-0.37
Room Air-0.43

Primary Safety Outcome Measure is a Comparison of the Change in National Institutes of Health Stroke Scale (NIHSS) Scores From Baseline to 24 Hours (After Therapy) in the Two Groups.

The NIHSS score ranges from 0 (best score) to 42 (worst score). (NCT00414726)
Timeframe: 24 hours

Intervention0-24 hour change in NIHSS score (Mean)
Normobaric Oxygen0.17
Room Air-0.73

Reviews

1 review available for lactic acid and Apoplexy

ArticleYear
Astrocytic nutritional dysfunction associated with hypoxia-induced neuronal vulnerability in stroke-prone spontaneously hypertensive rats.
    Neurochemistry international, 2020, Volume: 138

    Topics: Animals; Astrocytes; Cell Death; Cells, Cultured; Humans; Hypertension; Hypoxia; Lactic Acid; Neuron

2020

Trials

9 trials available for lactic acid and Apoplexy

ArticleYear
Spectroscopy of reperfused tissue after stroke reveals heightened metabolism in patients with good clinical outcomes.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Brain; Cerebral Revascularization; Cerebrovascular Circulation; Diff

2014
Immediate effects of low-intensity laser (808 nm) on fatigue and strength of spastic muscle.
    Lasers in medical science, 2015, Volume: 30, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Cross-Sectional Studies; Double-Blind Method; Female; Humans; Lactic

2015
Randomized, controlled trial of insulin for acute poststroke hyperglycemia.
    Annals of neurology, 2010, Volume: 67, Issue:5

    Topics: Acute Disease; Aged; Aged, 80 and over; Analysis of Variance; Blood Glucose; Brain Infarction; Creat

2010
Metabolic counterpart of decreased apparent diffusion coefficient during hyperacute ischemic stroke: a brain proton magnetic resonance spectroscopic imaging study.
    Stroke, 2003, Volume: 34, Issue:7

    Topics: Acute Disease; Adult; Aged; Aspartic Acid; Brain; Brain Ischemia; Cerebrovascular Circulation; Diffu

2003
Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS.
    Brain & development, 2004, Volume: 26, Issue:7

    Topics: Abdominal Pain; Administration, Oral; Adolescent; Chemical and Drug Induced Liver Injury; Child; Dic

2004
Magnetic resonance spectroscopy study of oxygen therapy in ischemic stroke.
    Stroke, 2007, Volume: 38, Issue:10

    Topics: Acute Disease; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Ischemia; Diffusion Magnetic Res

2007
Cerebral microdialysis monitoring: determination of normal and ischemic cerebral metabolisms in patients with aneurysmal subarachnoid hemorrhage.
    Journal of neurosurgery, 2000, Volume: 93, Issue:5

    Topics: Adult; Aged; Brain; Brain Death; Brain Ischemia; Cerebral Angiography; Extracellular Space; Glucose;

2000
Spectroscopic assessment of alterations in macromolecule and small-molecule metabolites in human brain after stroke.
    Stroke, 2001, Dec-01, Volume: 32, Issue:12

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Brain; Choline; Creatine; Disease Progression; Female;

2001
Spectroscopic data following stroke reveal tissue abnormality beyond the region of T2-weighted hyperintensity.
    Journal of the neurological sciences, 2002, Jul-15, Volume: 199, Issue:1-2

    Topics: Aspartic Acid; Choline; Creatine; Female; Humans; Infarction, Middle Cerebral Artery; Lactic Acid; M

2002

Other Studies

62 other studies available for lactic acid and Apoplexy

ArticleYear
Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome.
    Journal of neurology, 2022, Volume: 269, Issue:6

    Topics: Adult; Alanine; Case-Control Studies; DNA, Mitochondrial; Female; Glutamic Acid; Glutamine; Humans;

2022
Visual memory failure presages conversion to MELAS phenotype.
    Annals of clinical and translational neurology, 2022, Volume: 9, Issue:6

    Topics: Brain; Humans; Lactic Acid; MELAS Syndrome; Phenotype; Stroke

2022
Disseminated stroke-like episodes lesions in MELAS are partially reversible with lactate disappearance.
    Acta neurologica Belgica, 2023, Volume: 123, Issue:4

    Topics: Humans; Lactic Acid; Magnetic Resonance Spectroscopy; MELAS Syndrome; Stroke

2023
Related factors based on non-targeted metabolomics methods in minor ischaemic stroke.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Biomarkers; Blood Glucose; Brain Ischemia; C-Reactive Protein; Homocysteine; Humans; Hypertension; I

2022
Predicting the Onset of Ischemic Stroke With Fast High-Resolution 3D MR Spectroscopic Imaging.
    Journal of magnetic resonance imaging : JMRI, 2023, Volume: 58, Issue:3

    Topics: Aspartic Acid; Bayes Theorem; Choline; Creatine; Cross-Sectional Studies; Humans; Ischemic Stroke; L

2023
Pre-stroke exercise does not reduce atrophy in healthy young adult mice.
    Neuroscience letters, 2023, 09-25, Volume: 814

    Topics: Animals; Atrophy; Brain; Disease Models, Animal; Humans; Infarction, Middle Cerebral Artery; Lactic

2023
An Unusual Cause of Stroke-Like Symptoms in an Elderly Patient.
    Annals of the Academy of Medicine, Singapore, 2019, Volume: 48, Issue:9

    Topics: Aphasia; Cerebral Angiography; Diagnosis, Differential; Electroencephalography; Humans; Lactic Acid;

2019
Comparison of a Genetic Algorithm Variable Selection and Interval Partial Least Squares for quantitative analysis of lactate in PBS.
    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2019, Volume: 2019

    Topics: Algorithms; Brain Ischemia; Humans; Lactic Acid; Least-Squares Analysis; Stroke

2019
Evaluating the potential of hyperpolarised [1-
    Scientific reports, 2020, 03-26, Volume: 10, Issue:1

    Topics: Animals; Bicarbonates; Biosensing Techniques; Brain Ischemia; Carbon Isotopes; Computer Systems; Dis

2020
Usefulness of the NULL-PLEASE Score to Predict Survival in Out-of-Hospital Cardiac Arrest.
    The American journal of medicine, 2020, Volume: 133, Issue:11

    Topics: Age Factors; Aged; Aged, 80 and over; Cardiopulmonary Resuscitation; Electric Countershock; Female;

2020
Comparison of wavelength selection methods for in-vitro estimation of lactate: a new unconstrained, genetic algorithm-based wavelength selection.
    Scientific reports, 2020, 10-09, Volume: 10, Issue:1

    Topics: Algorithms; Biomarkers; Critical Illness; Humans; Intensive Care Units; Lactic Acid; Shock, Septic;

2020
Admission blood lactate levels of patients diagnosed with cerebrovascular disease effects on short- and long-term mortality risk.
    International journal of clinical practice, 2021, Volume: 75, Issue:8

    Topics: Brain Ischemia; Hospital Mortality; Humans; Hyperlactatemia; Lactic Acid; Prognosis; Retrospective S

2021
Standard-sampling microdialysis and spreading depolarizations in patients with malignant hemispheric stroke.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017, Volume: 37, Issue:5

    Topics: Cerebral Cortex; Cerebral Infarction; Cortical Spreading Depression; Electrocorticography; Female; G

2017
Skin perfusion pressure as an indicator of tissue perfusion in valvular heart surgery: Preliminary results from a prospective, observational study.
    PloS one, 2017, Volume: 12, Issue:9

    Topics: Acute Kidney Injury; Aged; Area Under Curve; Cardiopulmonary Bypass; Female; Heart Valve Diseases; H

2017
Perfluorocarbon Enhanced Glasgow Oxygen Level Dependent (GOLD) Magnetic Resonance Metabolic Imaging Identifies the Penumbra Following Acute Ischemic Stroke.
    Theranostics, 2018, Volume: 8, Issue:6

    Topics: Animals; Autoradiography; Brain; Brain Ischemia; Brain Mapping; Carbon Radioisotopes; Contrast Media

2018
Comparison between cerebrospinal fluid and serum lactate concentrations in neurologic dogs with and without structural intracranial disease.
    Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2018, Volume: 82, Issue:2

    Topics: Animals; Brain Neoplasms; Cysts; Dog Diseases; Dogs; Epilepsy; Lactic Acid; Meningoencephalitis; Oti

2018
Protective Effect of Cholic Acid-Coated Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles Loaded with Erythropoietin on Experimental Stroke.
    Journal of nanoscience and nanotechnology, 2019, 10-01, Volume: 19, Issue:10

    Topics: Animals; Cholic Acid; Drug Carriers; Erythropoietin; Glycolates; Lactic Acid; Nanoparticles; Polygly

2019
Transient ischemic attack-like episodes without stroke-like lesions in MELAS.
    Pediatric radiology, 2013, Volume: 43, Issue:10

    Topics: Biomarkers; Brain; Child; Diagnosis, Differential; Female; Humans; Ischemic Attack, Transient; Lacti

2013
The association of plasma lactate with incident cardiovascular outcomes: the ARIC Study.
    American journal of epidemiology, 2013, Aug-01, Volume: 178, Issue:3

    Topics: Alcohol Drinking; Biomarkers; Community-Based Participatory Research; Comorbidity; Coronary Disease;

2013
Ischemic stroke penumbra and extracorporeal ozone treatment.
    The neuroradiology journal, 2013, Volume: 26, Issue:3

    Topics: Adenosine Triphosphate; Apoptosis; Brain Edema; Disabled Persons; Disease Progression; Glutathione R

2013
Bioengineered sequential growth factor delivery stimulates brain tissue regeneration after stroke.
    Journal of controlled release : official journal of the Controlled Release Society, 2013, Nov-28, Volume: 172, Issue:1

    Topics: Absorbable Implants; Animals; Brain; Delayed-Action Preparations; Drug Delivery Systems; Epidermal G

2013
Excitotoxicity and metabolic changes in association with infarct progression.
    Stroke, 2014, Volume: 45, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Brain; Cerebral Infarction; Disease Progression; Female; Glucose; Gl

2014
Metabolic T1 dynamics and longitudinal relaxation enhancement in vivo at ultrahigh magnetic fields on ischemia.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:11

    Topics: Animals; Aspartic Acid; Brain Ischemia; Cerebral Angiography; Cerebrovascular Circulation; Choline;

2014
Metabolic properties in stroked rats revealed by relaxation-enhanced magnetic resonance spectroscopy at ultrahigh fields.
    Nature communications, 2014, Sep-17, Volume: 5

    Topics: Animals; Biomarkers; Brain; Disease Models, Animal; Ischemia; Lactic Acid; Magnetic Fields; Magnetic

2014
Reduced cerebral monocarboxylate transporters and lactate levels by ethanol and normobaric oxygen therapy in severe transient and permanent ischemic stroke.
    Brain research, 2015, Apr-07, Volume: 1603

    Topics: Acidosis, Lactic; Animals; Brain; Brain Ischemia; Combined Modality Therapy; Disease Models, Animal;

2015
Electro-acupuncture up-regulates astrocytic MCT1 expression to improve neurological deficit in middle cerebral artery occlusion rats.
    Life sciences, 2015, Aug-01, Volume: 134

    Topics: Animals; Astrocytes; Biological Transport, Active; Brain; Electroacupuncture; Glial Fibrillary Acidi

2015
Circumventing the blood-brain barrier: Local delivery of cyclosporin A stimulates stem cells in stroke-injured rat brain.
    Journal of controlled release : official journal of the Controlled Release Society, 2015, Oct-10, Volume: 215

    Topics: Animals; Blood-Brain Barrier; Brain Infarction; Cell Count; Cyclosporine; Drug Compounding; Drug Del

2015
Cardiac autonomic dysfunction in chronic stroke women is attenuated after submaximal exercise test, as evaluated by linear and nonlinear analysis.
    BMC cardiovascular disorders, 2015, Sep-29, Volume: 15

    Topics: Aged; Blood Glucose; Blood Pressure; Chronic Disease; Exercise Test; Female; Follow-Up Studies; Hear

2015
Incidence and predictors of ischemic cerebrovascular stroke among patients on extracorporeal membrane oxygenation support.
    Journal of critical care, 2016, Volume: 32

    Topics: Adult; Aged; Biomarkers; Critical Illness; Extracorporeal Membrane Oxygenation; Female; Florida; Hum

2016
Transverse relaxation of selectively excited metabolites in stroke at 21.1 T.
    Magnetic resonance in medicine, 2017, Volume: 77, Issue:2

    Topics: Animals; Brain; Equipment Design; Equipment Failure Analysis; Lactic Acid; Male; Proton Magnetic Res

2017
Early rehabilitation aggravates brain damage after stroke via enhanced activation of nicotinamide adenine dinucleotide phosphate oxidase (NOX).
    Brain research, 2016, 10-01, Volume: 1648, Issue:Pt A

    Topics: Animals; Apoptosis; Brain Injuries; Cerebral Cortex; Glucose Transporter Type 1; Glucose Transporter

2016
Brain metabolic pattern analysis using a magnetic resonance spectra classification software in experimental stroke.
    BMC neuroscience, 2017, 01-13, Volume: 18, Issue:1

    Topics: Animals; Brain; Brain Ischemia; Creatine; Image Processing, Computer-Assisted; Inositol; Lactic Acid

2017
1H/13C MR spectroscopic imaging of regionally specific metabolic alterations after experimental stroke.
    Brain : a journal of neurology, 2008, Volume: 131, Issue:Pt 8

    Topics: Animals; Aspartic Acid; Brain; Carbon Isotopes; Glucose; Glutamic Acid; Glutamine; Lactic Acid; Magn

2008
Evaluation of lactate as a marker of metabolic stress and cause of secondary damage in acute ischemic stroke or TIA.
    Clinica chimica acta; international journal of clinical chemistry, 2008, Volume: 397, Issue:1-2

    Topics: Aged; Aged, 80 and over; Biomarkers; Female; Humans; Ischemic Attack, Transient; Lactic Acid; Male;

2008
Normalization of brain tissue lactate after hyperbaric oxygen therapy in a progressive stroke patient.
    Cerebrovascular diseases (Basel, Switzerland), 2008, Volume: 26, Issue:4

    Topics: Brain; Female; Humans; Hyperbaric Oxygenation; Lactic Acid; Magnetic Resonance Imaging; Middle Aged;

2008
Increased brain lactate during stroke-like episode in a patient with congenital disorder of glycosylation type Ia.
    Brain & development, 2009, Volume: 31, Issue:2

    Topics: Acidosis, Lactic; Aspartic Acid; Brain; Carbohydrate Metabolism, Inborn Errors; Child; Female; Fever

2009
Changes in NAA and lactate following ischemic stroke: a serial MR spectroscopic imaging study.
    Neurology, 2008, Dec-09, Volume: 71, Issue:24

    Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Brain; Brain Ischemia; Brain Mapping; Cel

2008
Associations between diffusion and perfusion parameters, N-acetyl aspartate, and lactate in acute ischemic stroke.
    Stroke, 2009, Volume: 40, Issue:3

    Topics: Acute Disease; Aspartic Acid; Brain Ischemia; Cell Death; Cerebrovascular Circulation; Diffusion Mag

2009
Fenofibrate-loaded PLGA microparticles: effects on ischemic stroke.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2009, Apr-11, Volume: 37, Issue:1

    Topics: Animals; Biocompatible Materials; Biological Availability; Cerebral Infarction; Delayed-Action Prepa

2009
Pathophysiologic evaluation of MELAS strokes by serially quantified MRS and CASL perfusion images.
    Brain & development, 2010, Volume: 32, Issue:2

    Topics: Adult; Aspartic Acid; Brain; Cerebrovascular Circulation; Child; Diagnostic Imaging; Female; Humans;

2010
Early brain temperature elevation and anaerobic metabolism in human acute ischaemic stroke.
    Brain : a journal of neurology, 2009, Volume: 132, Issue:Pt 4

    Topics: Aged; Aged, 80 and over; Body Temperature; Brain; Brain Ischemia; Fever; Humans; Lactic Acid; Magnet

2009
Stroke-like episodes in propionic acidemia caused by central focal metabolic decompensation.
    Neuropediatrics, 2009, Volume: 40, Issue:2

    Topics: Amino Acids; Basal Ganglia; Cerebral Cortex; Child; Electroencephalography; Female; Functional Later

2009
Effect of mannitol on brain metabolism and tissue oxygenation in severe haemorrhagic stroke.
    Journal of neurology, neurosurgery, and psychiatry, 2011, Volume: 82, Issue:4

    Topics: Adult; Blood Pressure; Brain; Diuretics, Osmotic; Female; Glasgow Coma Scale; Glucose; Humans; Intra

2011
Characterization of the pattern of ischemic stroke induced by artificial particle embolization in the rat brain.
    Biomaterials, 2011, Volume: 32, Issue:27

    Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Chitin; Embolism;

2011
[Neuroprotector effect of human recombinant erythropoietin sorbed on polymer nanoparticles studied on model of intracerebral post-traumatic hematoma (hemorrhagic stroke)].
    Eksperimental'naia i klinicheskaia farmakologiia, 2011, Volume: 74, Issue:10

    Topics: Adsorption; Amnesia; Animals; Cerebral Hemorrhage; Disease Models, Animal; Enbucrilate; Erythropoiet

2011
Initial hyperlactatemia in the ED is associated with poor outcome in patients with ischemic stroke.
    The American journal of emergency medicine, 2012, Volume: 30, Issue:3

    Topics: Aged; Aged, 80 and over; Biomarkers; Blood Glucose; Brain Ischemia; Emergency Service, Hospital; Fem

2012
[Plasma metabonomics study of ischemic cerebral apoplexy rats treated with Tongsaimai pellets].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2012, Volume: 37, Issue:7

    Topics: Animals; Brain Ischemia; Drugs, Chinese Herbal; Fructose; Glyceric Acids; Hydroxyproline; Lactic Aci

2012
Neo-vascularization of the stroke cavity by implantation of human neural stem cells on VEGF-releasing PLGA microparticles.
    Biomaterials, 2012, Volume: 33, Issue:30

    Topics: Animals; Astrocytes; Brain; Cell Differentiation; Cell Lineage; Humans; Inflammation; Lactic Acid; M

2012
[Imaging findings in autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) - CADASIL - the most frequent familial stroke syndrome].
    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 2012, Volume: 184, Issue:8

    Topics: Aged; Brain; CADASIL; Choline; Chromosome Aberrations; Dementia, Vascular; Diffusion Magnetic Resona

2012
A hydrogel composite system for sustained epi-cortical delivery of Cyclosporin A to the brain for treatment of stroke.
    Journal of controlled release : official journal of the Controlled Release Society, 2013, Mar-28, Volume: 166, Issue:3

    Topics: Animals; Brain; Chromatography, Liquid; Cyclosporine; Delayed-Action Preparations; Drug Delivery Sys

2013
Neuroprotection conferred by post-ischemia ethanol therapy in experimental stroke: an inhibitory effect on hyperglycolysis and NADPH oxidase activation.
    Journal of neurochemistry, 2013, Volume: 126, Issue:1

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Behavior, Animal; Blood Glucose; Brain Chemi

2013
Release of fatty acid amides in a patient with hemispheric stroke: a microdialysis study.
    Stroke, 2002, Volume: 33, Issue:8

    Topics: Aged; Amides; Arachidonic Acids; Brain; Brain Chemistry; Brain Ischemia; Endocannabinoids; Ethanolam

2002
Biochemical markers of cerebrospinal ischemia after repair of aneurysms of the descending and thoracoabdominal aorta.
    Journal of cardiothoracic and vascular anesthesia, 2003, Volume: 17, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Biomarkers; C

2003
A newborn piglet study of moderate hypoxic-ischemic brain injury by 1H-MRS and MRI.
    Magnetic resonance imaging, 2004, Volume: 22, Issue:4

    Topics: Animals; Animals, Newborn; Aspartic Acid; Basal Ganglia; Cerebral Cortex; Cerebrovascular Circulatio

2004
Multiple spin-echo spectroscopic imaging for rapid quantitative assessment of N-acetylaspartate and lactate in acute stroke.
    Magnetic resonance in medicine, 2004, Volume: 52, Issue:2

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Analysis of Variance; Aspartic Acid; Case-Control Stu

2004
Beneficial effect of L-arginine for stroke-like episode in MELAS.
    Brain & development, 2004, Volume: 26, Issue:7

    Topics: Adolescent; Arginine; Brain; Brain Ischemia; Drug Therapy, Combination; Energy Metabolism; Female; G

2004
Can the outcome of pediatric extracorporeal membrane oxygenation after cardiac surgery be predicted?
    Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 2006, Volume: 12, Issue:1

    Topics: Cardiac Surgical Procedures; Cardiotonic Agents; Child; Child, Preschool; Disseminated Intravascular

2006
Multiparametric analysis of cerebral substrates and nitric oxide delivery in cerebrospinal fluid in patients with intracerebral haemorrhage: correlation with hemodynamics and outcome.
    Acta neurochirurgica, 2006, Volume: 148, Issue:6

    Topics: Adult; Aged; Amino Acids; Carbohydrates; Cerebral Hemorrhage; Cerebrospinal Fluid; Cerebrovascular C

2006
Effects of naloxone on lactate, pyruvate metabolism and antioxidant enzyme activity in rat cerebral ischemia/reperfusion.
    Neuroscience letters, 2000, Jun-23, Volume: 287, Issue:2

    Topics: Animals; Antioxidants; Brain; Catalase; Energy Metabolism; Free Radicals; Glutathione Peroxidase; Is

2000
Reduced production of lactate during hypoxia and reoxygenation in astrocytes isolated from stroke-prone spontaneously hypertensive rats.
    Neuroscience letters, 2000, Dec-22, Volume: 296, Issue:2-3

    Topics: Animals; Astrocytes; Carrier Proteins; Cell Death; Cells, Cultured; Fetus; Hypoxia, Brain; L-Lactate

2000
Neurologic course of congenital disorders of glycosylation.
    Journal of child neurology, 2001, Volume: 16, Issue:6

    Topics: Aspartic Acid; Brain; Brain Diseases, Metabolic, Inborn; Child; Child, Preschool; Congenital Disorde

2001
Mitochondrial disease and stroke.
    Stroke, 2001, Volume: 32, Issue:11

    Topics: Adolescent; Adult; Brain Ischemia; DNA, Mitochondrial; Female; Humans; Lactic Acid; Male; Mitochondr

2001