lactic acid has been researched along with Apoplexy in 72 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a genetically heterogeneous disorder caused by mitochondrial DNA (mtDNA) mutations in the MT-TL1 gene." | 8.12 | Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome. ( Arenas, J; Arranz-Canales, E; Delmiro, A; Domínguez-González, C; González de la Aleja, J; Guerrero-Molina, MP; Martín, MA; Morales-Conejo, M; Morán, M; Ramos-González, A, 2022) |
| "We here reported the clinical course and therapeutic details of a 16-year-old girl with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) who had had five stroke-like episodes (two episodes were clinically mild, while the three subsequent episodes were severe)." | 7.72 | Beneficial effect of L-arginine for stroke-like episode in MELAS. ( Kubota, M; Momoi-Yoshida, M; Mori, M; Sakakihara, Y; Yamagata, T, 2004) |
| "However, the treatment of stroke using the vast majority of possible drug candidates, including erythropoietin (EPO), remains problematic because of the presence of the blood-brain barrier (BBB), resulting in scarce penetration onto the brain." | 5.51 | Protective Effect of Cholic Acid-Coated Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles Loaded with Erythropoietin on Experimental Stroke. ( Han, SY; Jeong, JH; Jeong, YG; Kang, SH; Kim, DK; Lee, NS, 2019) |
| "The long-term effects of the sodium salt of dichloroacetic acid (DCA) were evaluated in four patients with mitochondrial encephalomyelopathy with lactic acidosis and stroke-like episodes (MELAS) carrying A3243G mutation." | 5.11 | Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS. ( Goto, T; Momoi, MY; Mori, M; Saito, S; Yamagata, T, 2004) |
| " The authors' goal was to characterize patterns of markers of energy metabolism (glucose, pyruvate, and lactate) and neuronal injury (glutamate and glycerol) in patients with subarachnoid hemorrhage (SAH), in whom ischemia was or was not suspected." | 5.09 | Cerebral microdialysis monitoring: determination of normal and ischemic cerebral metabolisms in patients with aneurysmal subarachnoid hemorrhage. ( Bjerre, P; Schulz, MK; Tange, M; Wang, LP, 2000) |
| "We sought to measure the temporal evolution and spatial distribution of lesion macromolecules and small molecules (lactate, N-acetyl compounds, creatine, and choline) in stroke patients by using short echo time in vivo proton MR spectroscopy." | 5.09 | Spectroscopic assessment of alterations in macromolecule and small-molecule metabolites in human brain after stroke. ( Graham, GD; Hwang, JH; Prichard, JW; Rothman, DL, 2001) |
| "Lesional NAA and creatine were significantly lower in subacute than in acute stroke." | 4.31 | Predicting the Onset of Ischemic Stroke With Fast High-Resolution 3D MR Spectroscopic Imaging. ( Bo, B; Guan, Y; Guo, R; Li, Y; Liang, ZP; Lin, DJ; Lin, Z; Liu, J; Meng, Z; Nachev, P; Wang, T; Yu, X; Zhao, Y; Zhou, H, 2023) |
| "Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a genetically heterogeneous disorder caused by mitochondrial DNA (mtDNA) mutations in the MT-TL1 gene." | 4.12 | Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome. ( Arenas, J; Arranz-Canales, E; Delmiro, A; Domínguez-González, C; González de la Aleja, J; Guerrero-Molina, MP; Martín, MA; Morales-Conejo, M; Morán, M; Ramos-González, A, 2022) |
| "To examine the correlation between verbal and visual memory function and correlation with brain metabolites (lactate and N-Acetylaspartate, NAA) in individuals with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)." | 4.12 | Visual memory failure presages conversion to MELAS phenotype. ( De Vivo, DC; DiMauro, S; Engelstad, K; Fryer, RH; Gu, Y; Hinton, VJ; Hirano, M; Leaffer, EB; Shungu, DC, 2022) |
| "Increased levels of lactic acid, pyruvate, and TMAO may be related to the pathophysiological changes in the minor ischaemic stroke population." | 4.12 | Related factors based on non-targeted metabolomics methods in minor ischaemic stroke. ( Chen, C; Ding, L; Guo, J; Liu, H; Ma, Y; Qiao, X; Wang, J; Wang, M; Yang, T; Zhao, S, 2022) |
| "Ischemic stroke is not uncommon in subjects receiving ECMO support with independent risk factor being a pre-ECMO lactic acid greater than 10 mmol/L." | 3.83 | Incidence and predictors of ischemic cerebrovascular stroke among patients on extracorporeal membrane oxygenation support. ( Camporesi, EM; Enten, G; Mangar, D; Mirsaeidi, M; Omar, HR; Shumac, J, 2016) |
| " Here we sought to identify whether the enhanced lactic acidosis and increased expression of monocarboxylate transporters (MCTs) observed after stroke might be attenuated by single and/or combined EtOH and NBO therapies." | 3.81 | Reduced cerebral monocarboxylate transporters and lactate levels by ethanol and normobaric oxygen therapy in severe transient and permanent ischemic stroke. ( Brogan, D; Cai, L; Ding, Y; Du, H; Geng, X; Ji, X; Kwiecien, TD; Peng, C; Rafols, JA; Rastogi, R; Singh, S; Sy, CA, 2015) |
| "A stroke-like episode is a core symptom in mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS)." | 3.79 | Transient ischemic attack-like episodes without stroke-like lesions in MELAS. ( Aida, N; Mitani, T; Osaka, H; Tomiyasu, M; Wada, T, 2013) |
| "To clarify the roles of serial MR spectroscopy (MRS) and continuous arterial spin labeling (CASL) perfusion images for evaluating cerebral lesions in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)." | 3.76 | Pathophysiologic evaluation of MELAS strokes by serially quantified MRS and CASL perfusion images. ( Ikawa, M; Kimura, H; Kudo, T; Kuriyama, M; Okazawa, H; Shimizu, Y; Toyooka, M; Tsujikawa, T; Uematsu, H; Yoneda, M, 2010) |
| "We here reported the clinical course and therapeutic details of a 16-year-old girl with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) who had had five stroke-like episodes (two episodes were clinically mild, while the three subsequent episodes were severe)." | 3.72 | Beneficial effect of L-arginine for stroke-like episode in MELAS. ( Kubota, M; Momoi-Yoshida, M; Mori, M; Sakakihara, Y; Yamagata, T, 2004) |
| "Poststroke hyperglycemia is common and is associated with increased risk of death and dependence, but appropriate management remains uncertain." | 2.75 | Randomized, controlled trial of insulin for acute poststroke hyperglycemia. ( Condon, B; Hadley, D; Macfarlane, JA; McCormick, M; McLean, JR; Muir, KW, 2010) |
| "NAA/choline (Cho) ratios were significantly reduced in both areas of T2 hyperintensity and in surrounding tissue." | 2.70 | Spectroscopic data following stroke reveal tissue abnormality beyond the region of T2-weighted hyperintensity. ( Beley, A; Brunotte, F; Demougeot, C; Giroud, M; Marie, C; Rouaud, O; Walker, P, 2002) |
| "Stroke is the main cause of acquired disability in adults." | 1.91 | Pre-stroke exercise does not reduce atrophy in healthy young adult mice. ( Brox, C; Christiansen, CL; Doosje, HL; Geiseler, SJ; Liesz, A; Morland, C; Nguyen, TD; Phan, KD; Tartanoglu, C, 2023) |
| "Hyperlactatemia was defined as a lactate level of over 2 mmol/L." | 1.62 | Admission blood lactate levels of patients diagnosed with cerebrovascular disease effects on short- and long-term mortality risk. ( Ak, R; Cimilli Ozturk, T; Kırkpantur, ED; Sakal, C; Taşçı, A; Ünal Akoğlu, E, 2021) |
| "However, the treatment of stroke using the vast majority of possible drug candidates, including erythropoietin (EPO), remains problematic because of the presence of the blood-brain barrier (BBB), resulting in scarce penetration onto the brain." | 1.51 | Protective Effect of Cholic Acid-Coated Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles Loaded with Erythropoietin on Experimental Stroke. ( Han, SY; Jeong, JH; Jeong, YG; Kang, SH; Kim, DK; Lee, NS, 2019) |
| "Stroke is a leading cause of disability with no effective regenerative treatment." | 1.39 | Bioengineered sequential growth factor delivery stimulates brain tissue regeneration after stroke. ( Cooke, MJ; Morshead, CM; Sachewsky, N; Shoichet, MS; Wang, Y, 2013) |
| "Embolism is responsible for half of cerebral infarctions, yet few animal models were developed due to the unpredictability of the embolus-induced infarcts." | 1.37 | Characterization of the pattern of ischemic stroke induced by artificial particle embolization in the rat brain. ( Kuo, YM; Tsai, MJ; Tsai, YH, 2011) |
| "It is well known that some mitochondrial disorders are responsible for ischemic cerebral infarction in young patients." | 1.31 | Mitochondrial disease and stroke. ( Aguilera, I; Arenas, J; Bautista, J; Campos, Y; Chinchón, I; Fernández-López, O; García-Lozano, R; Gil-Peralta, A; Martínez-Fernández, E, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 26 (36.11) | 29.6817 |
| 2010's | 35 (48.61) | 24.3611 |
| 2020's | 11 (15.28) | 2.80 |
| Authors | Studies |
|---|---|
| Guerrero-Molina, MP | 1 |
| Morales-Conejo, M | 1 |
| Delmiro, A | 1 |
| Morán, M | 1 |
| Domínguez-González, C | 1 |
| Arranz-Canales, E | 1 |
| Ramos-González, A | 1 |
| Arenas, J | 2 |
| Martín, MA | 1 |
| González de la Aleja, J | 1 |
| Leaffer, EB | 1 |
| De Vivo, DC | 1 |
| Engelstad, K | 1 |
| Fryer, RH | 1 |
| Gu, Y | 1 |
| Shungu, DC | 1 |
| Hirano, M | 1 |
| DiMauro, S | 1 |
| Hinton, VJ | 1 |
| Kobayashi, Y | 1 |
| Karasawa, S | 1 |
| Ohashi, N | 1 |
| Yamamoto, K | 1 |
| Chen, C | 1 |
| Qiao, X | 1 |
| Guo, J | 1 |
| Yang, T | 1 |
| Wang, M | 1 |
| Ma, Y | 1 |
| Zhao, S | 1 |
| Ding, L | 1 |
| Liu, H | 1 |
| Wang, J | 1 |
| Lin, Z | 1 |
| Meng, Z | 1 |
| Wang, T | 2 |
| Guo, R | 1 |
| Zhao, Y | 1 |
| Li, Y | 2 |
| Bo, B | 1 |
| Guan, Y | 1 |
| Liu, J | 1 |
| Zhou, H | 1 |
| Yu, X | 1 |
| Lin, DJ | 1 |
| Liang, ZP | 1 |
| Nachev, P | 1 |
| Geiseler, SJ | 1 |
| Phan, KD | 1 |
| Brox, C | 1 |
| Nguyen, TD | 1 |
| Tartanoglu, C | 1 |
| Doosje, HL | 1 |
| Christiansen, CL | 1 |
| Liesz, A | 1 |
| Morland, C | 1 |
| Kee, CK | 1 |
| Ngam, PI | 1 |
| Tan, AP | 1 |
| Mamouei, M | 2 |
| Qassem, M | 2 |
| Budidha, K | 2 |
| Baishya, N | 2 |
| Vadgama, P | 1 |
| Kyriacou, PA | 1 |
| Hyacinthe, JN | 1 |
| Buscemi, L | 1 |
| Lê, TP | 1 |
| Lepore, M | 1 |
| Hirt, L | 1 |
| Mishkovsky, M | 1 |
| Gue, YX | 1 |
| Sayers, M | 1 |
| Whitby, BT | 1 |
| Kanji, R | 1 |
| Adatia, K | 1 |
| Smith, R | 1 |
| Davies, WR | 1 |
| Perperoglou, A | 1 |
| Potpara, TS | 1 |
| Lip, GYH | 1 |
| Gorog, DA | 1 |
| Yamagata, K | 2 |
| Kyriacou, P | 1 |
| Sakal, C | 1 |
| Ak, R | 1 |
| Taşçı, A | 1 |
| Kırkpantur, ED | 1 |
| Ünal Akoğlu, E | 1 |
| Cimilli Ozturk, T | 1 |
| Pinczolits, A | 2 |
| Zdunczyk, A | 1 |
| Dengler, NF | 1 |
| Hecht, N | 2 |
| Kowoll, CM | 1 |
| Dohmen, C | 1 |
| Graf, R | 1 |
| Winkler, MK | 1 |
| Major, S | 1 |
| Hartings, JA | 1 |
| Dreier, JP | 2 |
| Vajkoczy, P | 2 |
| Woitzik, J | 2 |
| Song, Y | 1 |
| Soh, S | 1 |
| Shim, JK | 1 |
| Park, KU | 1 |
| Kwak, YL | 1 |
| Deuchar, GA | 1 |
| Brennan, D | 1 |
| Holmes, WM | 1 |
| Shaw, M | 1 |
| Macrae, IM | 1 |
| Santosh, C | 1 |
| Benedicenti, L | 1 |
| Gianotti, G | 1 |
| Galban, EM | 1 |
| Jeong, JH | 1 |
| Kang, SH | 1 |
| Kim, DK | 1 |
| Lee, NS | 1 |
| Jeong, YG | 1 |
| Han, SY | 1 |
| Mitani, T | 1 |
| Aida, N | 1 |
| Tomiyasu, M | 1 |
| Wada, T | 1 |
| Osaka, H | 1 |
| Matsushita, K | 1 |
| Williams, EK | 1 |
| Mongraw-Chaffin, ML | 1 |
| Coresh, J | 1 |
| Schmidt, MI | 1 |
| Brancati, FL | 1 |
| Hoogeveen, RC | 1 |
| Ballantyne, CM | 1 |
| Young, JH | 1 |
| Wasser, G | 1 |
| Wang, Y | 3 |
| Cooke, MJ | 2 |
| Sachewsky, N | 1 |
| Morshead, CM | 3 |
| Shoichet, MS | 3 |
| Sandow, N | 1 |
| Scheel, M | 1 |
| Drenckhahn, C | 1 |
| Shemesh, N | 3 |
| Rosenberg, JT | 3 |
| Dumez, JN | 3 |
| Grant, SC | 3 |
| Frydman, L | 3 |
| Muniz, JA | 2 |
| Bivard, A | 1 |
| Krishnamurthy, V | 1 |
| Stanwell, P | 1 |
| Yassi, N | 1 |
| Spratt, NJ | 1 |
| Nilsson, M | 1 |
| Levi, CR | 1 |
| Davis, S | 1 |
| Parsons, MW | 1 |
| dos Reis, MC | 1 |
| de Andrade, EA | 1 |
| Borges, AC | 1 |
| de Souza, DQ | 1 |
| Lima, FP | 1 |
| Nicolau, RA | 1 |
| Andrade, AO | 1 |
| Lima, MO | 1 |
| Geng, X | 3 |
| Sy, CA | 1 |
| Kwiecien, TD | 1 |
| Ji, X | 1 |
| Peng, C | 3 |
| Rastogi, R | 1 |
| Cai, L | 1 |
| Du, H | 1 |
| Brogan, D | 1 |
| Singh, S | 1 |
| Rafols, JA | 1 |
| Ding, Y | 3 |
| Lu, Y | 1 |
| Zhao, H | 2 |
| Han, B | 1 |
| Cui, K | 1 |
| Wang, S | 1 |
| Tuladhar, A | 2 |
| Francica, JV | 1 |
| Bigongiari, A | 1 |
| Mochizuki, L | 1 |
| Scapini, KB | 1 |
| Moraes, OA | 1 |
| Mostarda, C | 1 |
| Caperuto, EC | 1 |
| Irigoyen, MC | 1 |
| De Angelis, K | 1 |
| Rodrigues, B | 1 |
| Omar, HR | 1 |
| Mirsaeidi, M | 1 |
| Shumac, J | 1 |
| Enten, G | 1 |
| Mangar, D | 1 |
| Camporesi, EM | 1 |
| Shen, J | 1 |
| Huber, M | 1 |
| Zhao, EY | 1 |
| Li, F | 1 |
| Li, X | 1 |
| Jiménez-Xarrié, E | 1 |
| Davila, M | 1 |
| Candiota, AP | 1 |
| Delgado-Mederos, R | 1 |
| Ortega-Martorell, S | 1 |
| Julià-Sapé, M | 1 |
| Arús, C | 1 |
| Martí-Fàbregas, J | 1 |
| van der Zijden, JP | 1 |
| van Eijsden, P | 1 |
| de Graaf, RA | 1 |
| Dijkhuizen, RM | 1 |
| Brouns, R | 1 |
| Sheorajpanday, R | 1 |
| Wauters, A | 1 |
| De Surgeloose, D | 1 |
| Mariën, P | 1 |
| De Deyn, PP | 1 |
| Lee, JI | 1 |
| Wittsack, HJ | 1 |
| Christaras, A | 1 |
| Miese, FR | 1 |
| Siebler, M | 1 |
| van Baalen, A | 1 |
| Stephani, U | 1 |
| Rohr, A | 1 |
| Muñoz Maniega, S | 1 |
| Cvoro, V | 3 |
| Chappell, FM | 1 |
| Armitage, PA | 3 |
| Marshall, I | 3 |
| Bastin, ME | 3 |
| Wardlaw, JM | 3 |
| Rivers, CS | 1 |
| Carpenter, TK | 1 |
| Wartolowska, K | 2 |
| Farrall, AJ | 1 |
| Dennis, MS | 2 |
| Klose, D | 1 |
| Laprais, M | 1 |
| Leroux, V | 1 |
| Siepmann, F | 1 |
| Deprez, B | 1 |
| Bordet, R | 1 |
| Siepmann, J | 1 |
| Tsujikawa, T | 1 |
| Yoneda, M | 1 |
| Shimizu, Y | 1 |
| Uematsu, H | 1 |
| Toyooka, M | 1 |
| Ikawa, M | 1 |
| Kudo, T | 1 |
| Okazawa, H | 1 |
| Kuriyama, M | 1 |
| Kimura, H | 1 |
| Karaszewski, B | 1 |
| Haga, K | 1 |
| Scholl-Bürgi, S | 1 |
| Haberlandt, E | 1 |
| Gotwald, T | 1 |
| Albrecht, U | 1 |
| Baumgartner Sigl, S | 1 |
| Rauchenzauner, M | 1 |
| Rostásy, K | 1 |
| Karall, D | 1 |
| McCormick, M | 1 |
| Hadley, D | 1 |
| McLean, JR | 1 |
| Macfarlane, JA | 1 |
| Condon, B | 1 |
| Muir, KW | 1 |
| Helbok, R | 1 |
| Kurtz, P | 1 |
| Schmidt, JM | 1 |
| Stuart, RM | 1 |
| Fernandez, L | 1 |
| Malhotra, R | 1 |
| Presciutti, M | 1 |
| Ostapkovich, ND | 1 |
| Connolly, ES | 1 |
| Lee, K | 1 |
| Badjatia, N | 1 |
| Mayer, SA | 1 |
| Claassen, J | 1 |
| Tsai, MJ | 1 |
| Tsai, YH | 1 |
| Kuo, YM | 1 |
| Balaban'ian, VIu | 1 |
| Solev, IN | 1 |
| Elizarova, OS | 1 |
| Garibova, TL | 1 |
| Litvinova, SA | 1 |
| Voronina, TA | 1 |
| Jo, S | 1 |
| Jeong, T | 1 |
| Lee, JB | 1 |
| Jin, YH | 1 |
| Yoon, J | 1 |
| Jun, YK | 1 |
| Park, B | 1 |
| Tu, J | 1 |
| A, J | 1 |
| Wang, G | 1 |
| Wen, H | 1 |
| Wang, A | 1 |
| Di, L | 1 |
| Cao, B | 1 |
| Liu, L | 1 |
| Bible, E | 1 |
| Qutachi, O | 1 |
| Chau, DY | 1 |
| Alexander, MR | 1 |
| Shakesheff, KM | 1 |
| Modo, M | 1 |
| Bender, B | 1 |
| Bornemann, A | 1 |
| Reimold, M | 1 |
| Ernemann, U | 1 |
| Horger, M | 1 |
| Caicco, MJ | 1 |
| Kochanski, R | 1 |
| Higashida, T | 1 |
| Hüttemann, M | 1 |
| Guthikonda, M | 1 |
| Schäbitz, WR | 1 |
| Giuffrida, A | 1 |
| Berger, C | 1 |
| Aschoff, A | 1 |
| Schwaninger, M | 1 |
| Schwab, S | 1 |
| Piomelli, D | 1 |
| Nicoli, F | 1 |
| Lefur, Y | 1 |
| Denis, B | 1 |
| Ranjeva, JP | 1 |
| Confort-Gouny, S | 1 |
| Cozzone, PJ | 1 |
| Anderson, RE | 1 |
| Winnerkvist, A | 1 |
| Hansson, LO | 1 |
| Nilsson, O | 1 |
| Rosengren, L | 1 |
| Settergren, G | 1 |
| Vaage, J | 1 |
| Vial, F | 1 |
| Serriere, S | 1 |
| Barantin, L | 1 |
| Montharu, J | 1 |
| Nadal-Desbarats, L | 1 |
| Pourcelot, L | 1 |
| Seguin, F | 1 |
| Stengel, A | 1 |
| Neumann-Haefelin, T | 1 |
| Singer, OC | 1 |
| Neumann-Haefelin, C | 1 |
| Zanella, FE | 1 |
| Lanfermann, H | 1 |
| Pilatus, U | 1 |
| Mori, M | 2 |
| Yamagata, T | 2 |
| Goto, T | 1 |
| Saito, S | 1 |
| Momoi, MY | 1 |
| Kubota, M | 1 |
| Sakakihara, Y | 1 |
| Momoi-Yoshida, M | 1 |
| Baslaim, G | 1 |
| Bashore, J | 1 |
| Al-Malki, F | 1 |
| Jamjoom, A | 1 |
| Chiang, MF | 1 |
| Chiu, WT | 1 |
| Lin, FJ | 1 |
| Thajeb, P | 1 |
| Huang, CJ | 1 |
| Tsai, SH | 1 |
| Singhal, AB | 1 |
| Ratai, E | 1 |
| Benner, T | 1 |
| Vangel, M | 1 |
| Lee, V | 1 |
| Koroshetz, WJ | 1 |
| Schaefer, PW | 1 |
| Sorensen, AG | 1 |
| Gonzalez, RG | 1 |
| Chen, CJ | 1 |
| Cheng, FC | 1 |
| Liao, SL | 1 |
| Chen, WY | 1 |
| Lin, NN | 1 |
| Kuo, JS | 1 |
| Schulz, MK | 1 |
| Wang, LP | 1 |
| Tange, M | 1 |
| Bjerre, P | 1 |
| Tagami, M | 1 |
| Ikeda, K | 1 |
| Noguchi, T | 1 |
| Yamori, Y | 1 |
| Nara, Y | 1 |
| Pearl, PL | 1 |
| Krasnewich, D | 1 |
| Martínez-Fernández, E | 1 |
| Gil-Peralta, A | 1 |
| García-Lozano, R | 1 |
| Chinchón, I | 1 |
| Aguilera, I | 1 |
| Fernández-López, O | 1 |
| Campos, Y | 1 |
| Bautista, J | 1 |
| Graham, GD | 1 |
| Hwang, JH | 1 |
| Rothman, DL | 1 |
| Prichard, JW | 1 |
| Demougeot, C | 1 |
| Walker, P | 1 |
| Beley, A | 1 |
| Marie, C | 1 |
| Rouaud, O | 1 |
| Giroud, M | 1 |
| Brunotte, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Low Level LASER Therapy on Spasticity and Gait Parameters in Chronic Stroke Patients With Spastic Planter Flexors.[NCT05425225] | 18 participants (Anticipated) | Interventional | 2022-03-04 | Recruiting | |||
| Clinical Trial of Normobaric Oxygen Therapy in Acute Ischemic Stroke[NCT00414726] | Phase 2 | 85 participants (Actual) | Interventional | 2007-01-31 | Terminated (stopped due to Imbalance in deaths favoring control arm; deaths not attributed to treatment by the blinded external medical monitor.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The NIHSS score ranges from 0 (best score) to 42 (worst score). (NCT00414726)
Timeframe: 4 hours after starting treatment
| Intervention | 0-4 hour change in NIHSS score (Mean) |
|---|---|
| Normobaric Oxygen | -0.37 |
| Room Air | -0.43 |
The NIHSS score ranges from 0 (best score) to 42 (worst score). (NCT00414726)
Timeframe: 24 hours
| Intervention | 0-24 hour change in NIHSS score (Mean) |
|---|---|
| Normobaric Oxygen | 0.17 |
| Room Air | -0.73 |
1 review available for lactic acid and Apoplexy
| Article | Year |
|---|---|
Astrocytic nutritional dysfunction associated with hypoxia-induced neuronal vulnerability in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Astrocytes; Cell Death; Cells, Cultured; Humans; Hypertension; Hypoxia; Lactic Acid; Neuron | 2020 |
9 trials available for lactic acid and Apoplexy
| Article | Year |
|---|---|
Spectroscopy of reperfused tissue after stroke reveals heightened metabolism in patients with good clinical outcomes.
Topics: Adult; Aged; Aged, 80 and over; Brain; Cerebral Revascularization; Cerebrovascular Circulation; Diff | 2014 |
Immediate effects of low-intensity laser (808 nm) on fatigue and strength of spastic muscle.
Topics: Adult; Aged; Aged, 80 and over; Cross-Sectional Studies; Double-Blind Method; Female; Humans; Lactic | 2015 |
Randomized, controlled trial of insulin for acute poststroke hyperglycemia.
Topics: Acute Disease; Aged; Aged, 80 and over; Analysis of Variance; Blood Glucose; Brain Infarction; Creat | 2010 |
Metabolic counterpart of decreased apparent diffusion coefficient during hyperacute ischemic stroke: a brain proton magnetic resonance spectroscopic imaging study.
Topics: Acute Disease; Adult; Aged; Aspartic Acid; Brain; Brain Ischemia; Cerebrovascular Circulation; Diffu | 2003 |
Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS.
Topics: Abdominal Pain; Administration, Oral; Adolescent; Chemical and Drug Induced Liver Injury; Child; Dic | 2004 |
Magnetic resonance spectroscopy study of oxygen therapy in ischemic stroke.
Topics: Acute Disease; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Ischemia; Diffusion Magnetic Res | 2007 |
Cerebral microdialysis monitoring: determination of normal and ischemic cerebral metabolisms in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Brain; Brain Death; Brain Ischemia; Cerebral Angiography; Extracellular Space; Glucose; | 2000 |
Spectroscopic assessment of alterations in macromolecule and small-molecule metabolites in human brain after stroke.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Brain; Choline; Creatine; Disease Progression; Female; | 2001 |
Spectroscopic data following stroke reveal tissue abnormality beyond the region of T2-weighted hyperintensity.
Topics: Aspartic Acid; Choline; Creatine; Female; Humans; Infarction, Middle Cerebral Artery; Lactic Acid; M | 2002 |
62 other studies available for lactic acid and Apoplexy
| Article | Year |
|---|---|
Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome.
Topics: Adult; Alanine; Case-Control Studies; DNA, Mitochondrial; Female; Glutamic Acid; Glutamine; Humans; | 2022 |
Visual memory failure presages conversion to MELAS phenotype.
Topics: Brain; Humans; Lactic Acid; MELAS Syndrome; Phenotype; Stroke | 2022 |
Disseminated stroke-like episodes lesions in MELAS are partially reversible with lactate disappearance.
Topics: Humans; Lactic Acid; Magnetic Resonance Spectroscopy; MELAS Syndrome; Stroke | 2023 |
Related factors based on non-targeted metabolomics methods in minor ischaemic stroke.
Topics: Biomarkers; Blood Glucose; Brain Ischemia; C-Reactive Protein; Homocysteine; Humans; Hypertension; I | 2022 |
Predicting the Onset of Ischemic Stroke With Fast High-Resolution 3D MR Spectroscopic Imaging.
Topics: Aspartic Acid; Bayes Theorem; Choline; Creatine; Cross-Sectional Studies; Humans; Ischemic Stroke; L | 2023 |
Pre-stroke exercise does not reduce atrophy in healthy young adult mice.
Topics: Animals; Atrophy; Brain; Disease Models, Animal; Humans; Infarction, Middle Cerebral Artery; Lactic | 2023 |
An Unusual Cause of Stroke-Like Symptoms in an Elderly Patient.
Topics: Aphasia; Cerebral Angiography; Diagnosis, Differential; Electroencephalography; Humans; Lactic Acid; | 2019 |
Comparison of a Genetic Algorithm Variable Selection and Interval Partial Least Squares for quantitative analysis of lactate in PBS.
Topics: Algorithms; Brain Ischemia; Humans; Lactic Acid; Least-Squares Analysis; Stroke | 2019 |
Evaluating the potential of hyperpolarised [1-
Topics: Animals; Bicarbonates; Biosensing Techniques; Brain Ischemia; Carbon Isotopes; Computer Systems; Dis | 2020 |
Usefulness of the NULL-PLEASE Score to Predict Survival in Out-of-Hospital Cardiac Arrest.
Topics: Age Factors; Aged; Aged, 80 and over; Cardiopulmonary Resuscitation; Electric Countershock; Female; | 2020 |
Comparison of wavelength selection methods for in-vitro estimation of lactate: a new unconstrained, genetic algorithm-based wavelength selection.
Topics: Algorithms; Biomarkers; Critical Illness; Humans; Intensive Care Units; Lactic Acid; Shock, Septic; | 2020 |
Admission blood lactate levels of patients diagnosed with cerebrovascular disease effects on short- and long-term mortality risk.
Topics: Brain Ischemia; Hospital Mortality; Humans; Hyperlactatemia; Lactic Acid; Prognosis; Retrospective S | 2021 |
Standard-sampling microdialysis and spreading depolarizations in patients with malignant hemispheric stroke.
Topics: Cerebral Cortex; Cerebral Infarction; Cortical Spreading Depression; Electrocorticography; Female; G | 2017 |
Skin perfusion pressure as an indicator of tissue perfusion in valvular heart surgery: Preliminary results from a prospective, observational study.
Topics: Acute Kidney Injury; Aged; Area Under Curve; Cardiopulmonary Bypass; Female; Heart Valve Diseases; H | 2017 |
Perfluorocarbon Enhanced Glasgow Oxygen Level Dependent (GOLD) Magnetic Resonance Metabolic Imaging Identifies the Penumbra Following Acute Ischemic Stroke.
Topics: Animals; Autoradiography; Brain; Brain Ischemia; Brain Mapping; Carbon Radioisotopes; Contrast Media | 2018 |
Comparison between cerebrospinal fluid and serum lactate concentrations in neurologic dogs with and without structural intracranial disease.
Topics: Animals; Brain Neoplasms; Cysts; Dog Diseases; Dogs; Epilepsy; Lactic Acid; Meningoencephalitis; Oti | 2018 |
Protective Effect of Cholic Acid-Coated Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles Loaded with Erythropoietin on Experimental Stroke.
Topics: Animals; Cholic Acid; Drug Carriers; Erythropoietin; Glycolates; Lactic Acid; Nanoparticles; Polygly | 2019 |
Transient ischemic attack-like episodes without stroke-like lesions in MELAS.
Topics: Biomarkers; Brain; Child; Diagnosis, Differential; Female; Humans; Ischemic Attack, Transient; Lacti | 2013 |
The association of plasma lactate with incident cardiovascular outcomes: the ARIC Study.
Topics: Alcohol Drinking; Biomarkers; Community-Based Participatory Research; Comorbidity; Coronary Disease; | 2013 |
Ischemic stroke penumbra and extracorporeal ozone treatment.
Topics: Adenosine Triphosphate; Apoptosis; Brain Edema; Disabled Persons; Disease Progression; Glutathione R | 2013 |
Bioengineered sequential growth factor delivery stimulates brain tissue regeneration after stroke.
Topics: Absorbable Implants; Animals; Brain; Delayed-Action Preparations; Drug Delivery Systems; Epidermal G | 2013 |
Excitotoxicity and metabolic changes in association with infarct progression.
Topics: Adult; Aged; Aged, 80 and over; Brain; Cerebral Infarction; Disease Progression; Female; Glucose; Gl | 2014 |
Metabolic T1 dynamics and longitudinal relaxation enhancement in vivo at ultrahigh magnetic fields on ischemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cerebral Angiography; Cerebrovascular Circulation; Choline; | 2014 |
Metabolic properties in stroked rats revealed by relaxation-enhanced magnetic resonance spectroscopy at ultrahigh fields.
Topics: Animals; Biomarkers; Brain; Disease Models, Animal; Ischemia; Lactic Acid; Magnetic Fields; Magnetic | 2014 |
Reduced cerebral monocarboxylate transporters and lactate levels by ethanol and normobaric oxygen therapy in severe transient and permanent ischemic stroke.
Topics: Acidosis, Lactic; Animals; Brain; Brain Ischemia; Combined Modality Therapy; Disease Models, Animal; | 2015 |
Electro-acupuncture up-regulates astrocytic MCT1 expression to improve neurological deficit in middle cerebral artery occlusion rats.
Topics: Animals; Astrocytes; Biological Transport, Active; Brain; Electroacupuncture; Glial Fibrillary Acidi | 2015 |
Circumventing the blood-brain barrier: Local delivery of cyclosporin A stimulates stem cells in stroke-injured rat brain.
Topics: Animals; Blood-Brain Barrier; Brain Infarction; Cell Count; Cyclosporine; Drug Compounding; Drug Del | 2015 |
Cardiac autonomic dysfunction in chronic stroke women is attenuated after submaximal exercise test, as evaluated by linear and nonlinear analysis.
Topics: Aged; Blood Glucose; Blood Pressure; Chronic Disease; Exercise Test; Female; Follow-Up Studies; Hear | 2015 |
Incidence and predictors of ischemic cerebrovascular stroke among patients on extracorporeal membrane oxygenation support.
Topics: Adult; Aged; Biomarkers; Critical Illness; Extracorporeal Membrane Oxygenation; Female; Florida; Hum | 2016 |
Transverse relaxation of selectively excited metabolites in stroke at 21.1 T.
Topics: Animals; Brain; Equipment Design; Equipment Failure Analysis; Lactic Acid; Male; Proton Magnetic Res | 2017 |
Early rehabilitation aggravates brain damage after stroke via enhanced activation of nicotinamide adenine dinucleotide phosphate oxidase (NOX).
Topics: Animals; Apoptosis; Brain Injuries; Cerebral Cortex; Glucose Transporter Type 1; Glucose Transporter | 2016 |
Brain metabolic pattern analysis using a magnetic resonance spectra classification software in experimental stroke.
Topics: Animals; Brain; Brain Ischemia; Creatine; Image Processing, Computer-Assisted; Inositol; Lactic Acid | 2017 |
1H/13C MR spectroscopic imaging of regionally specific metabolic alterations after experimental stroke.
Topics: Animals; Aspartic Acid; Brain; Carbon Isotopes; Glucose; Glutamic Acid; Glutamine; Lactic Acid; Magn | 2008 |
Evaluation of lactate as a marker of metabolic stress and cause of secondary damage in acute ischemic stroke or TIA.
Topics: Aged; Aged, 80 and over; Biomarkers; Female; Humans; Ischemic Attack, Transient; Lactic Acid; Male; | 2008 |
Normalization of brain tissue lactate after hyperbaric oxygen therapy in a progressive stroke patient.
Topics: Brain; Female; Humans; Hyperbaric Oxygenation; Lactic Acid; Magnetic Resonance Imaging; Middle Aged; | 2008 |
Increased brain lactate during stroke-like episode in a patient with congenital disorder of glycosylation type Ia.
Topics: Acidosis, Lactic; Aspartic Acid; Brain; Carbohydrate Metabolism, Inborn Errors; Child; Female; Fever | 2009 |
Changes in NAA and lactate following ischemic stroke: a serial MR spectroscopic imaging study.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Brain; Brain Ischemia; Brain Mapping; Cel | 2008 |
Associations between diffusion and perfusion parameters, N-acetyl aspartate, and lactate in acute ischemic stroke.
Topics: Acute Disease; Aspartic Acid; Brain Ischemia; Cell Death; Cerebrovascular Circulation; Diffusion Mag | 2009 |
Fenofibrate-loaded PLGA microparticles: effects on ischemic stroke.
Topics: Animals; Biocompatible Materials; Biological Availability; Cerebral Infarction; Delayed-Action Prepa | 2009 |
Pathophysiologic evaluation of MELAS strokes by serially quantified MRS and CASL perfusion images.
Topics: Adult; Aspartic Acid; Brain; Cerebrovascular Circulation; Child; Diagnostic Imaging; Female; Humans; | 2010 |
Early brain temperature elevation and anaerobic metabolism in human acute ischaemic stroke.
Topics: Aged; Aged, 80 and over; Body Temperature; Brain; Brain Ischemia; Fever; Humans; Lactic Acid; Magnet | 2009 |
Stroke-like episodes in propionic acidemia caused by central focal metabolic decompensation.
Topics: Amino Acids; Basal Ganglia; Cerebral Cortex; Child; Electroencephalography; Female; Functional Later | 2009 |
Effect of mannitol on brain metabolism and tissue oxygenation in severe haemorrhagic stroke.
Topics: Adult; Blood Pressure; Brain; Diuretics, Osmotic; Female; Glasgow Coma Scale; Glucose; Humans; Intra | 2011 |
Characterization of the pattern of ischemic stroke induced by artificial particle embolization in the rat brain.
Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Chitin; Embolism; | 2011 |
[Neuroprotector effect of human recombinant erythropoietin sorbed on polymer nanoparticles studied on model of intracerebral post-traumatic hematoma (hemorrhagic stroke)].
Topics: Adsorption; Amnesia; Animals; Cerebral Hemorrhage; Disease Models, Animal; Enbucrilate; Erythropoiet | 2011 |
Initial hyperlactatemia in the ED is associated with poor outcome in patients with ischemic stroke.
Topics: Aged; Aged, 80 and over; Biomarkers; Blood Glucose; Brain Ischemia; Emergency Service, Hospital; Fem | 2012 |
[Plasma metabonomics study of ischemic cerebral apoplexy rats treated with Tongsaimai pellets].
Topics: Animals; Brain Ischemia; Drugs, Chinese Herbal; Fructose; Glyceric Acids; Hydroxyproline; Lactic Aci | 2012 |
Neo-vascularization of the stroke cavity by implantation of human neural stem cells on VEGF-releasing PLGA microparticles.
Topics: Animals; Astrocytes; Brain; Cell Differentiation; Cell Lineage; Humans; Inflammation; Lactic Acid; M | 2012 |
[Imaging findings in autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) - CADASIL - the most frequent familial stroke syndrome].
Topics: Aged; Brain; CADASIL; Choline; Chromosome Aberrations; Dementia, Vascular; Diffusion Magnetic Resona | 2012 |
A hydrogel composite system for sustained epi-cortical delivery of Cyclosporin A to the brain for treatment of stroke.
Topics: Animals; Brain; Chromatography, Liquid; Cyclosporine; Delayed-Action Preparations; Drug Delivery Sys | 2013 |
Neuroprotection conferred by post-ischemia ethanol therapy in experimental stroke: an inhibitory effect on hyperglycolysis and NADPH oxidase activation.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Behavior, Animal; Blood Glucose; Brain Chemi | 2013 |
Release of fatty acid amides in a patient with hemispheric stroke: a microdialysis study.
Topics: Aged; Amides; Arachidonic Acids; Brain; Brain Chemistry; Brain Ischemia; Endocannabinoids; Ethanolam | 2002 |
Biochemical markers of cerebrospinal ischemia after repair of aneurysms of the descending and thoracoabdominal aorta.
Topics: Adult; Aged; Aged, 80 and over; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Biomarkers; C | 2003 |
A newborn piglet study of moderate hypoxic-ischemic brain injury by 1H-MRS and MRI.
Topics: Animals; Animals, Newborn; Aspartic Acid; Basal Ganglia; Cerebral Cortex; Cerebrovascular Circulatio | 2004 |
Multiple spin-echo spectroscopic imaging for rapid quantitative assessment of N-acetylaspartate and lactate in acute stroke.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Analysis of Variance; Aspartic Acid; Case-Control Stu | 2004 |
Beneficial effect of L-arginine for stroke-like episode in MELAS.
Topics: Adolescent; Arginine; Brain; Brain Ischemia; Drug Therapy, Combination; Energy Metabolism; Female; G | 2004 |
Can the outcome of pediatric extracorporeal membrane oxygenation after cardiac surgery be predicted?
Topics: Cardiac Surgical Procedures; Cardiotonic Agents; Child; Child, Preschool; Disseminated Intravascular | 2006 |
Multiparametric analysis of cerebral substrates and nitric oxide delivery in cerebrospinal fluid in patients with intracerebral haemorrhage: correlation with hemodynamics and outcome.
Topics: Adult; Aged; Amino Acids; Carbohydrates; Cerebral Hemorrhage; Cerebrospinal Fluid; Cerebrovascular C | 2006 |
Effects of naloxone on lactate, pyruvate metabolism and antioxidant enzyme activity in rat cerebral ischemia/reperfusion.
Topics: Animals; Antioxidants; Brain; Catalase; Energy Metabolism; Free Radicals; Glutathione Peroxidase; Is | 2000 |
Reduced production of lactate during hypoxia and reoxygenation in astrocytes isolated from stroke-prone spontaneously hypertensive rats.
Topics: Animals; Astrocytes; Carrier Proteins; Cell Death; Cells, Cultured; Fetus; Hypoxia, Brain; L-Lactate | 2000 |
Neurologic course of congenital disorders of glycosylation.
Topics: Aspartic Acid; Brain; Brain Diseases, Metabolic, Inborn; Child; Child, Preschool; Congenital Disorde | 2001 |
Mitochondrial disease and stroke.
Topics: Adolescent; Adult; Brain Ischemia; DNA, Mitochondrial; Female; Humans; Lactic Acid; Male; Mitochondr | 2001 |