lactic acid has been researched along with Anoxia-Ischemia, Brain in 95 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Our aim was to use magnetic resonance spectroscopy (MRS) biomarkers and immunohistochemistry to investigate the cerebral effects of the NHE inhibitor, methyl isobutyl amiloride (MIA) given after severe perinatal asphyxia in the piglet." | 7.79 | Methyl-isobutyl amiloride reduces brain Lac/NAA, cell death and microglial activation in a perinatal asphyxia model. ( Bainbridge, A; Cady, E; Chandrasekaran, M; Cheong, J; Faulkner, S; Hristova, M; Iwata, O; Iwata, S; Kapetanakis, A; Kato, T; Raivich, G; Robertson, NJ, 2013) |
| "To determine whether lactic acidosis at birth in asphyxiated neonates could predict the grade of EEG encephalopathy by examining the relationship between time taken for the normalisation of lactate, severity of encephalopathy and seizure burden." | 7.74 | Persistent lactic acidosis in neonatal hypoxic-ischaemic encephalopathy correlates with EEG grade and electrographic seizure burden. ( Boylan, GB; Connolly, S; Fitzgerald, AP; Murphy, BP; Murray, DM; Ryan, CA, 2008) |
| " Our aim was to use magnetic resonance spectroscopy (MRS) biomarkers and immunohistochemistry to investigate the cerebral effects of the NHE inhibitor, methyl isobutyl amiloride (MIA) given after severe perinatal asphyxia in the piglet." | 3.79 | Methyl-isobutyl amiloride reduces brain Lac/NAA, cell death and microglial activation in a perinatal asphyxia model. ( Bainbridge, A; Cady, E; Chandrasekaran, M; Cheong, J; Faulkner, S; Hristova, M; Iwata, O; Iwata, S; Kapetanakis, A; Kato, T; Raivich, G; Robertson, NJ, 2013) |
| "To determine whether lactic acidosis at birth in asphyxiated neonates could predict the grade of EEG encephalopathy by examining the relationship between time taken for the normalisation of lactate, severity of encephalopathy and seizure burden." | 3.74 | Persistent lactic acidosis in neonatal hypoxic-ischaemic encephalopathy correlates with EEG grade and electrographic seizure burden. ( Boylan, GB; Connolly, S; Fitzgerald, AP; Murphy, BP; Murray, DM; Ryan, CA, 2008) |
| "Currently, hypothermia is the only approved clinical treatment available for HIE." | 3.01 | Exogenous lactate administration: A potential novel therapeutic approach for neonatal hypoxia-ischemia. ( Deng, Q; Duan, R; Liu, TC; Wu, C; Yang, L, 2023) |
| "Bilirubin has been found to be a natural antioxidant protecting the body from oxidative stress." | 1.72 | The Relationship between Serum Total Bilirubin and Severity of Hypoxic Injury in Neonatal Hypoxic-Ischemic Encephalopathy. ( Haga, M; Imanishi, T; Kanno, C; Kanno, M; Kawabata, K; Kurita, S; Shimizu, M; Sumiya, W, 2022) |
| "Lactic acid and alanine were the primary metabolite predictors for the development of HIE, and when combined with clinical data, gave an area under the curve of 0." | 1.62 | Improvement in the Prediction of Neonatal Hypoxic-Ischemic Encephalopathy with the Integration of Umbilical Cord Metabolites and Current Clinical Makers. ( Boylan, GB; Broadhurst, DI; Dunn, WB; Hallberg, B; Kirwan, JA; Murray, DM; O'Boyle, DS; O'Neill, D, 2021) |
| "Taurine is an abundant amino acid in the nervous system, which has been proved to possess antioxidation, osmoregulation and membrane stabilization." | 1.43 | Neuroprotective actions of taurine on hypoxic-ischemic brain damage in neonatal rats. ( Hao, YJ; Li, YX; Ma, PS; Niu, Y; Sun, T; Wu, W; Yu, JQ; Zhou, R; Zhu, XY, 2016) |
| "Systemic arterial hypertension has been previously suggested to develop as a compensatory condition when central nervous perfusion/oxygenation is compromised." | 1.42 | Brainstem hypoxia contributes to the development of hypertension in the spontaneously hypertensive rat. ( Ang, R; Gourine, AV; Hosford, PS; Karagiannis, A; Kasparov, S; Kasymov, V; Machhada, A; Marina, N; Mosienko, V; Paton, JF; Teschemacher, AG; Vihko, P, 2015) |
| "For treatment, cycloheximide was given immediately after hypoxic ischemia (HI)." | 1.39 | Quantitative in vivo detection of brain cell death after hypoxia ischemia using the lipid peak at 1.3 ppm of proton magnetic resonance spectroscopy in neonatal rats. ( Ahn, SY; Chang, YS; Jung, YJ; Kim, KS; Lee, JH; Lim, KH; Park, WS; Sung, DK; Sung, SI; Yoo, HS, 2013) |
| "In two children with near drowning hypoxic encephalopathy and normal-appearing structural MRI, acute proton magnetic resonance spectroscopy ((1)H MRS) showed biochemical alterations that correctly indicated prognosis and helped to guide management decisions." | 1.35 | Prognostic value of proton magnetic resonance spectroscopy findings in near drowning patients: reversibility of the early metabolite abnormalities relates with a good outcome. ( Aragão, Mde F; Law, M; Naidich, T; Netto, JP; Valença, MM, 2009) |
| "These four children all had seizure activity and abnormal initial neurological examinations and required admission to the PICU." | 1.33 | Elevated lactate as an early marker of brain injury in inflicted traumatic brain injury. ( Ball, WS; Care, M; Cecil, KM; Makoroff, KL, 2005) |
| "During seizures, ATP and PCr values declined significantly below their homologous controls." | 1.31 | Prolonged neonatal seizures exacerbate hypoxic-ischemic brain damage: correlation with cerebral energy metabolism and excitatory amino acid release. ( Armstrong, EA; Miyashita, H; Wirrell, EC; Yager, JY, 2002) |
| "The mean occlusion time until cardiac arrest was 14." | 1.31 | Reduced postnatal cerebral glucose metabolism measured by PET after asphyxia in near term fetal lambs. ( Hellström-Westas, L; Hernandez-Andrade, E; Ley, D; Lingman, G; Marsal, K; Ohlsson, T; Oskarsson, G; Pesonen, E; Sandell, A; Strand, SE; Thorngren-Jerneck, K; Werner, O, 2001) |
| "Sensitivity and specificity were generally higher in the lactate group than in the pH group, particularly in relation to an Apgar score <4 at 5 minutes and moderate to severe hypoxic-ischemic encephalopathy." | 1.30 | Predictive value of fetal scalp blood lactate concentration and pH as markers of neurologic disability. ( Blennow, M; Hallberg, B; Kruger, K; Kublickas, M; Westgren, M, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (2.11) | 18.2507 |
| 2000's | 45 (47.37) | 29.6817 |
| 2010's | 29 (30.53) | 24.3611 |
| 2020's | 19 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chaudhari, P | 1 |
| Madaan, A | 1 |
| Rivera, JC | 1 |
| Charfi, I | 1 |
| Habelrih, T | 1 |
| Hou, X | 1 |
| Nezhady, M | 1 |
| Lodygensky, G | 1 |
| Pineyro, G | 1 |
| Muanza, T | 1 |
| Chemtob, S | 1 |
| Debillon, T | 1 |
| Sentilhes, L | 1 |
| Kayem, G | 1 |
| Chevallier, M | 1 |
| Zeitlin, J | 1 |
| Baud, O | 1 |
| Vilotitch, A | 1 |
| Pierrat, V | 1 |
| Guellec, I | 1 |
| Ancel, PY | 1 |
| Bednarek, N | 1 |
| Ego, A | 1 |
| Pavel, AM | 3 |
| O'Toole, JM | 3 |
| Proietti, J | 3 |
| Livingstone, V | 3 |
| Mitra, S | 5 |
| Marnane, WP | 3 |
| Finder, M | 3 |
| Dempsey, EM | 3 |
| Murray, DM | 6 |
| Boylan, GB | 6 |
| Galderisi, A | 2 |
| Tordin, M | 2 |
| Suppiej, A | 2 |
| Cainelli, E | 2 |
| Baraldi, E | 2 |
| Trevisanuto, D | 2 |
| Labat, J | 2 |
| Brocard, C | 2 |
| Belaroussi, Y | 2 |
| Bar, C | 2 |
| Gotchac, J | 2 |
| Chateil, JF | 3 |
| Brissaud, O | 2 |
| Cascant-Vilaplana, MM | 1 |
| Lara-Cantón, I | 1 |
| Núñez-Ramiro, A | 2 |
| Solaz-García, Á | 1 |
| Llorens-Salvador, R | 1 |
| Quintás, G | 2 |
| Kuligowski, J | 3 |
| Vento, M | 3 |
| Deng, Q | 1 |
| Wu, C | 1 |
| Liu, TC | 1 |
| Duan, R | 1 |
| Yang, L | 1 |
| Arulnathan, E | 1 |
| Manchanda, A | 1 |
| Dixit, R | 1 |
| Kumar, A | 1 |
| Gunes, AO | 1 |
| Karadag, N | 1 |
| Topcuoglu, S | 1 |
| Ozalkaya, E | 1 |
| Toptan, HH | 1 |
| Dincer, E | 1 |
| Cakir, H | 1 |
| Karatekin, G | 1 |
| Sanches, E | 1 |
| van de Looij, Y | 1 |
| Ho, D | 1 |
| Modernell, L | 1 |
| da Silva, A | 1 |
| Sizonenko, S | 1 |
| Liu, P | 1 |
| Deng, X | 1 |
| Peng, Y | 1 |
| Zhou, F | 1 |
| Zuo, Z | 1 |
| Roumes, H | 2 |
| Dumont, U | 1 |
| Sanchez, S | 1 |
| Mazuel, L | 1 |
| Blanc, J | 1 |
| Raffard, G | 1 |
| Pellerin, L | 2 |
| Bouzier-Sore, AK | 2 |
| Kyng, KJ | 1 |
| Kerrn-Jespersen, S | 1 |
| Bennedsgaard, K | 1 |
| Skajaa, T | 1 |
| Pedersen, M | 1 |
| Holm, IE | 1 |
| Henriksen, TB | 1 |
| Casey, S | 1 |
| Goasdoue, K | 1 |
| Miller, SM | 1 |
| Brennan, GP | 1 |
| Cowin, G | 1 |
| O'Mahony, AG | 1 |
| Burke, C | 1 |
| Hallberg, B | 3 |
| Sullivan, AM | 1 |
| Henshall, DC | 1 |
| O'Keeffe, GW | 1 |
| Mooney, C | 1 |
| Bjorkman, T | 1 |
| Tassinari, ID | 1 |
| Andrade, MKG | 1 |
| da Rosa, LA | 1 |
| Hoff, MLM | 1 |
| Nunes, RR | 1 |
| Vogt, EL | 1 |
| Fabres, RB | 1 |
| Sanches, EF | 1 |
| Netto, CA | 1 |
| Paz, AH | 1 |
| de Fraga, LS | 1 |
| O'Boyle, DS | 1 |
| Dunn, WB | 1 |
| O'Neill, D | 1 |
| Kirwan, JA | 1 |
| Broadhurst, DI | 1 |
| Haga, M | 1 |
| Kawabata, K | 1 |
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| Kurita, S | 1 |
| Imanishi, T | 1 |
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| Sokolska, M | 1 |
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| Kendall, GS | 1 |
| Meek, J | 2 |
| Tachtsidis, I | 4 |
| Robertson, NJ | 7 |
| Sánchez-Illana, Á | 2 |
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| Valverde, E | 1 |
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| Yoo, HS | 1 |
| Lee, JH | 2 |
| Sung, DK | 1 |
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| Sung, SI | 1 |
| Lim, KH | 1 |
| Chang, YS | 4 |
| Kim, KS | 2 |
| Park, WS | 4 |
| Brandão, LA | 1 |
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| Ang, R | 1 |
| Machhada, A | 1 |
| Kasymov, V | 1 |
| Karagiannis, A | 1 |
| Hosford, PS | 1 |
| Mosienko, V | 1 |
| Teschemacher, AG | 1 |
| Vihko, P | 1 |
| Paton, JF | 1 |
| Kasparov, S | 1 |
| Gourine, AV | 1 |
| Stark, MJ | 1 |
| Hodyl, NA | 1 |
| Belegar V, KK | 1 |
| Andersen, CC | 1 |
| Ezzati, M | 2 |
| Broad, KD | 2 |
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| Rostami, J | 1 |
| Jane Hassell, K | 1 |
| Gressens, P | 2 |
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| Bennett, K | 1 |
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| Yellon, D | 1 |
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| Golay, X | 2 |
| Hassell, J | 1 |
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| Hao, YJ | 1 |
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| Sun, T | 1 |
| Li, YX | 1 |
| Yu, JQ | 1 |
| Solberg, R | 1 |
| Lliso, I | 1 |
| Pankratov, L | 1 |
| Saugstad, OD | 3 |
| Zheng, Y | 1 |
| Wang, XM | 1 |
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| Perritt, R | 1 |
| Shankaran, S | 1 |
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| O'Shea, TM | 1 |
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| Liu, L | 2 |
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| Zhou, HY | 2 |
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| He, L | 2 |
| Ai, T | 1 |
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| Xue, J | 1 |
| Lee, BS | 1 |
| Woo, CW | 1 |
| Kim, ST | 1 |
| Bennet, L | 2 |
| Booth, L | 1 |
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| Wiberg, N | 1 |
| Källén, K | 1 |
| Herbst, A | 1 |
| Olofsson, P | 1 |
| Bhargava, D | 1 |
| Al-Tamimi, Y | 1 |
| Quinn, A | 1 |
| Ross, S | 1 |
| Cheng, G | 1 |
| Sun, J | 1 |
| Wang, L | 1 |
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| Larach, DB | 1 |
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| Nordstrom, L | 2 |
| Mann, C | 1 |
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| Lee, TF | 1 |
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| Chaudhary, H | 1 |
| Brocks, DR | 1 |
| Bigam, DL | 1 |
| Cheung, PY | 1 |
| Kato, T | 1 |
| Chandrasekaran, M | 1 |
| Iwata, O | 1 |
| Kapetanakis, A | 1 |
| Faulkner, S | 1 |
| Cheong, J | 1 |
| Iwata, S | 1 |
| Cady, E | 1 |
| Schurr, A | 3 |
| Barrier, L | 1 |
| Barc, S | 1 |
| Fauconneau, B | 1 |
| Pontcharraud, R | 1 |
| Kelani, A | 1 |
| Bestel, E | 1 |
| Page, G | 1 |
| Yager, JY | 1 |
| Armstrong, EA | 1 |
| Miyashita, H | 1 |
| Wirrell, EC | 1 |
| He, SR | 1 |
| Liu, R | 1 |
| Cai, M | 1 |
| Cai, Q | 1 |
| Li, GF | 1 |
| Xiao, JQ | 1 |
| Lin, YX | 1 |
| Huang, RY | 1 |
| Huang, JY | 1 |
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| Makoroff, KL | 1 |
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| Ley, D | 1 |
| Hellström-Westas, L | 1 |
| Hernandez-Andrade, E | 1 |
| Lingman, G | 1 |
| Ohlsson, T | 1 |
| Oskarsson, G | 1 |
| Pesonen, E | 1 |
| Sandell, A | 1 |
| Strand, SE | 1 |
| Werner, O | 1 |
| Marsal, K | 1 |
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| Zwiener, U | 1 |
| Johannsen, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Long Term Prognostic of Neonatal Hypoxic Ischemic Encephalopathy in the Era of Neuroprotective Treatment With Hypothermia[NCT02676063] | 800 participants (Anticipated) | Observational | 2015-09-30 | Active, not recruiting | |||
| A Multi-centre, Randomised, Controlled, Clinical Investigation of a Standalone Decision Support Algorithm for Neonatal Seizure Recognition[NCT02431780] | 264 participants (Actual) | Interventional | 2015-02-12 | Completed | |||
| Optimising the Duration of Cooling Therapy in Mild Neonatal Encephalopathy[NCT03409770] | 140 participants (Anticipated) | Interventional | 2019-10-10 | Active, not recruiting | |||
| Randomized Controlled Trial of Hypothermia for Hypoxic-Ischemic Encephalopathy in Term Infants[NCT00005772] | Phase 3 | 208 participants (Actual) | Interventional | 1999-10-31 | Completed | ||
| Follow-up Visit of High Risk Infants[NCT00009633] | 68,000 participants (Anticipated) | Observational | 1993-01-31 | Recruiting | |||
| A Multi-Centre Safety and Efficacy Study of Autologous Cord Blood Combined With Therapeutic Hypothermia Following Neonates Encephalopathy in China[NCT02551003] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2015-09-08 | Withdrawn (stopped due to The study did not commence due to unforeseen challenges in securing adequate funding and resources, coupled with logistical constraints.) | ||
| The Effect of Standardizing the Definition and Approach to a Clinically Significant Cardiopulmonary Event in Infants Less Than 30 Weeks on Length of Stay[NCT03414671] | 160 participants (Actual) | Observational | 2018-06-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for lactic acid and Anoxia-Ischemia, Brain
| Article | Year |
|---|---|
Exogenous lactate administration: A potential novel therapeutic approach for neonatal hypoxia-ischemia.
Topics: Humans; Hypothermia; Hypothermia, Induced; Hypoxia; Hypoxia-Ischemia, Brain; Infant, Newborn; Ischem | 2023 |
Temporal Evolution of Signal Alterations in the Deep Gray Nuclei in term Neonates With Hypoxic-Ischemic Brain Injury: A Comprehensive Review.
Topics: Brain; Brain Injuries; Diffusion Magnetic Resonance Imaging; Humans; Hypoxia-Ischemia, Brain; Infant | 2023 |
Brain Protection after Anoxic Brain Injury: Is Lactate Supplementation Helpful?
Topics: Acidosis; Animals; Brain Injuries, Traumatic; Cell Death; Cerebrovascular Circulation; Energy Metabo | 2021 |
Hypoxic-ischemic injuries: the role of magnetic resonance spectroscopy.
Topics: Americas; Aspartic Acid; Biomarkers; Brain; Humans; Hypoxia-Ischemia, Brain; Lactic Acid; Magnetic R | 2013 |
Magnetic resonance spectroscopy biomarkers in term perinatal asphyxial encephalopathy: from neuropathological correlates to future clinical applications.
Topics: Animals; Animals, Newborn; Aspartic Acid; Asphyxia Neonatorum; Biomarkers; Choline; Creatine; Diseas | 2014 |
Potential biomarkers for hypoxic-ischemic encephalopathy.
Topics: Asphyxia Neonatorum; Biomarkers; Creatinine; Developmental Disabilities; Humans; Hypothermia, Induce | 2010 |
Lactate, glucose and energy metabolism in the ischemic brain (Review).
Topics: Acidosis, Lactic; Anaerobiosis; Animals; Brain; Brain Damage, Chronic; Brain Ischemia; Corticosteron | 2002 |
Lactate measurements in scalp and cord arterial blood.
Topics: Acid-Base Imbalance; Biomarkers; Female; Fetal Blood; Fetal Diseases; Fetal Hypoxia; Humans; Hypoxia | 2001 |
Energy metabolism, stress hormones and neural recovery from cerebral ischemia/hypoxia.
Topics: Adrenal Cortex Hormones; Animals; Energy Metabolism; Humans; Hypoxia-Ischemia, Brain; Lactic Acid | 2002 |
5 trials available for lactic acid and Anoxia-Ischemia, Brain
| Article | Year |
|---|---|
Risk factors for unfavorable outcome at discharge of newborns with hypoxic-ischemic encephalopathy in the era of hypothermia.
Topics: Child; Hospital Mortality; Humans; Hypothermia; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infan | 2023 |
Evolution of Energy Related Metabolites in Plasma from Newborns with Hypoxic-Ischemic Encephalopathy during Hypothermia Treatment.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Biomarkers; Case-Control Studies; Female; Gas Chromatography-M | 2017 |
Association between urinary lactate to creatinine ratio and neurodevelopmental outcome in term infants with hypoxic-ischemic encephalopathy.
Topics: Adult; Biomarkers; Child Development; Creatinine; Female; Follow-Up Studies; Humans; Hypothermia, In | 2008 |
Association between urinary lactate to creatinine ratio and neurodevelopmental outcome in term infants with hypoxic-ischemic encephalopathy.
Topics: Adult; Biomarkers; Child Development; Creatinine; Female; Follow-Up Studies; Humans; Hypothermia, In | 2008 |
Association between urinary lactate to creatinine ratio and neurodevelopmental outcome in term infants with hypoxic-ischemic encephalopathy.
Topics: Adult; Biomarkers; Child Development; Creatinine; Female; Follow-Up Studies; Humans; Hypothermia, In | 2008 |
Association between urinary lactate to creatinine ratio and neurodevelopmental outcome in term infants with hypoxic-ischemic encephalopathy.
Topics: Adult; Biomarkers; Child Development; Creatinine; Female; Follow-Up Studies; Humans; Hypothermia, In | 2008 |
Outcome of severe intrapartum acidemia diagnosed with fetal scalp blood sampling.
Topics: Acidosis; Female; Fetal Blood; Humans; Hydrogen-Ion Concentration; Hypoxia-Ischemia, Brain; Infant, | 2011 |
Prognostic value of 1H-MRS in neonatal encephalopathy.
Topics: Apgar Score; Aspartic Acid; Asphyxia Neonatorum; Basal Ganglia; Choline; Creatine; Creatinine; Femal | 2006 |
81 other studies available for lactic acid and Anoxia-Ischemia, Brain
| Article | Year |
|---|---|
Neuronal GPR81 regulates developmental brain angiogenesis and promotes brain recovery after a hypoxic ischemic insult.
Topics: Animals; Animals, Newborn; Brain; Brain Injuries; Female; Hypoxia-Ischemia, Brain; Infarction; Ische | 2022 |
Machine learning for the early prediction of infants with electrographic seizures in neonatal hypoxic-ischemic encephalopathy.
Topics: Electroencephalography; Gestational Age; Humans; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; L | 2023 |
Machine learning for the early prediction of infants with electrographic seizures in neonatal hypoxic-ischemic encephalopathy.
Topics: Electroencephalography; Gestational Age; Humans; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; L | 2023 |
Machine learning for the early prediction of infants with electrographic seizures in neonatal hypoxic-ischemic encephalopathy.
Topics: Electroencephalography; Gestational Age; Humans; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; L | 2023 |
Machine learning for the early prediction of infants with electrographic seizures in neonatal hypoxic-ischemic encephalopathy.
Topics: Electroencephalography; Gestational Age; Humans; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; L | 2023 |
Machine learning for the early prediction of infants with electrographic seizures in neonatal hypoxic-ischemic encephalopathy.
Topics: Electroencephalography; Gestational Age; Humans; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; L | 2023 |
Machine learning for the early prediction of infants with electrographic seizures in neonatal hypoxic-ischemic encephalopathy.
Topics: Electroencephalography; Gestational Age; Humans; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; L | 2023 |
Machine learning for the early prediction of infants with electrographic seizures in neonatal hypoxic-ischemic encephalopathy.
Topics: Electroencephalography; Gestational Age; Humans; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; L | 2023 |
Machine learning for the early prediction of infants with electrographic seizures in neonatal hypoxic-ischemic encephalopathy.
Topics: Electroencephalography; Gestational Age; Humans; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; L | 2023 |
Machine learning for the early prediction of infants with electrographic seizures in neonatal hypoxic-ischemic encephalopathy.
Topics: Electroencephalography; Gestational Age; Humans; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; L | 2023 |
Glucose-to-lactate ratio and neurodevelopment in infants with hypoxic-ischemic encephalopathy: an observational study.
Topics: Glucose; Humans; Hyperglycemia; Hypoglycemia; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant; | 2023 |
Glucose-to-lactate ratio and neurodevelopment in infants with hypoxic-ischemic encephalopathy: an observational study.
Topics: Glucose; Humans; Hyperglycemia; Hypoglycemia; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant; | 2023 |
Glucose-to-lactate ratio and neurodevelopment in infants with hypoxic-ischemic encephalopathy: an observational study.
Topics: Glucose; Humans; Hyperglycemia; Hypoglycemia; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant; | 2023 |
Glucose-to-lactate ratio and neurodevelopment in infants with hypoxic-ischemic encephalopathy: an observational study.
Topics: Glucose; Humans; Hyperglycemia; Hypoglycemia; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant; | 2023 |
Hypothermia for neonatal hypoxic-ischemic encephalopathy: Retrospective descriptive study of features associated with poor outcome.
Topics: Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant, Newborn; Lactic Acid; Magnetic Resona | 2023 |
Hypothermia for neonatal hypoxic-ischemic encephalopathy: Retrospective descriptive study of features associated with poor outcome.
Topics: Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant, Newborn; Lactic Acid; Magnetic Resona | 2023 |
Hypothermia for neonatal hypoxic-ischemic encephalopathy: Retrospective descriptive study of features associated with poor outcome.
Topics: Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant, Newborn; Lactic Acid; Magnetic Resona | 2023 |
Hypothermia for neonatal hypoxic-ischemic encephalopathy: Retrospective descriptive study of features associated with poor outcome.
Topics: Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant, Newborn; Lactic Acid; Magnetic Resona | 2023 |
Longitudinal perturbations of plasma nuclear magnetic resonance profiles in neonatal encephalopathy.
Topics: 3-Hydroxybutyric Acid; Biomarkers; Brain Injuries; Humans; Hypothermia, Induced; Hypoxia-Ischemia, B | 2023 |
Factors Associated with the Transition Time to Full Enteral Feeding in Newborns with Hypoxic Ischemic Encephalopathy.
Topics: Birth Weight; Enteral Nutrition; Humans; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; Lactic Ac | 2022 |
Early Neuroprotective Effects of Bovine Lactoferrin Associated with Hypothermia after Neonatal Brain Hypoxia-Ischemia in Rats.
Topics: Animals; Animals, Newborn; Brain; Female; Hypothermia; Hypoxia-Ischemia, Brain; Inflammation; Lactic | 2023 |
Effect of Neotype Rectal Mild Hypothermia Therapy on Intestinal Bacterial Translocation in Rats with Hypoxic-Ischemic Brain Damage.
Topics: Amine Oxidase (Copper-Containing); Animals; Bacteria; Bacterial Translocation; Hypothermia, Induced; | 2020 |
Neuroprotective role of lactate in rat neonatal hypoxia-ischemia.
Topics: Animals; Disease Models, Animal; Female; Humans; Hypoxia-Ischemia, Brain; Lactic Acid; Rats; Rats, W | 2021 |
Short-term outcomes of remote ischemic postconditioning 1 h after perinatal hypoxia-ischemia in term piglets.
Topics: Animals; Animals, Newborn; Aspartic Acid; Biomarkers; Brain; Diffusion Magnetic Resonance Imaging; D | 2021 |
Temporally Altered miRNA Expression in a Piglet Model of Hypoxic Ischemic Brain Injury.
Topics: Animals; Animals, Newborn; Biomarkers; Bone Morphogenetic Protein Receptors, Type II; Brain; Brain I | 2020 |
Lactate Administration Reduces Brain Injury and Ameliorates Behavioral Outcomes Following Neonatal Hypoxia-Ischemia.
Topics: Animals; Animals, Newborn; Brain; Brain Injuries; Disease Models, Animal; Female; Hypoxia; Hypoxia-I | 2020 |
Improvement in the Prediction of Neonatal Hypoxic-Ischemic Encephalopathy with the Integration of Umbilical Cord Metabolites and Current Clinical Makers.
Topics: Alanine; Apgar Score; Asphyxia Neonatorum; Biomarkers; Case-Control Studies; Electroencephalography; | 2021 |
The Relationship between Serum Total Bilirubin and Severity of Hypoxic Injury in Neonatal Hypoxic-Ischemic Encephalopathy.
Topics: Antioxidants; Bilirubin; Biomarkers; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Lactic Acid; | 2022 |
[Neuroprotective role of lactate in neonatal hypoxia-ischemia].
Topics: Animals; Animals, Newborn; Brain; Disease Models, Animal; Energy Metabolism; Humans; Hypoxia-Ischemi | 2020 |
Pressure passivity of cerebral mitochondrial metabolism is associated with poor outcome following perinatal hypoxic ischemic brain injury.
Topics: Adenosine Triphosphate; Aspartic Acid; Blood Pressure; Brain; Cerebrovascular Circulation; Developme | 2019 |
Changes in Brain Metabolite Concentrations after Neonatal Hypoxic-ischemic Encephalopathy.
Topics: Aspartic Acid; Creatine; Female; Glutamic Acid; Glutamine; Gray Matter; Humans; Hypoxia-Ischemia, Br | 2018 |
Findings and patterns on MRI and MR spectroscopy in neonates after therapeutic hypothermia for hypoxic ischemic encephalopathy treatment.
Topics: Age Factors; Female; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant, Newborn; Lactic | 2013 |
Quantitative in vivo detection of brain cell death after hypoxia ischemia using the lipid peak at 1.3 ppm of proton magnetic resonance spectroscopy in neonatal rats.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Apoptosis; Brain; Cycloheximide; Hypoxia-Ischemia | 2013 |
[Blood lactate measurments as a diagnostic and prognostic tool after birth asphyxia in newborn infants with gestational age > or = 34 gestational weeks].
Topics: Asphyxia Neonatorum; Female; Follow-Up Studies; Gestational Age; Humans; Hydrogen-Ion Concentration; | 2013 |
Detecting brain injury in neonatal hypoxic ischemic encephalopathy: closing the gap between experimental and clinical research.
Topics: Analysis of Variance; Animals; Animals, Newborn; Blood Pressure; Brain Injuries; Disease Models, Ani | 2014 |
Brainstem hypoxia contributes to the development of hypertension in the spontaneously hypertensive rat.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Brain Stem; Disease Models, Animal; Disease Progres | 2015 |
Intrauterine inflammation, cerebral oxygen consumption and susceptibility to early brain injury in very preterm newborns.
Topics: Brain; Carotid Artery, Internal; Cerebral Hemorrhage; Chorioamnionitis; Extraction, Obstetrical; Fem | 2016 |
Immediate remote ischemic postconditioning after hypoxia ischemia in piglets protects cerebral white matter but not grey matter.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Aspartic Acid; Biomarkers; Brain Mapping; Disease | 2016 |
Inhaled 45-50% argon augments hypothermic brain protection in a piglet model of perinatal asphyxia.
Topics: Animals; Animals, Newborn; Argon; Aspartic Acid; Asphyxia Neonatorum; Blood Chemical Analysis; Blood | 2016 |
Neuroprotective actions of taurine on hypoxic-ischemic brain damage in neonatal rats.
Topics: Animals; Animals, Newborn; Apoptosis Inducing Factor; Brain Infarction; Brain Injuries; Female; Glut | 2016 |
Relationship Between Cerebral Oxygenation and Metabolism During Rewarming in Newborn Infants After Therapeutic Hypothermia Following Hypoxic-Ischemic Brain Injury.
Topics: Aspartic Acid; Biomarkers; Body Temperature Regulation; Cerebrovascular Circulation; Electron Transp | 2016 |
Assessment of phospholipid synthesis related biomarkers for perinatal asphyxia: a piglet study.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Biomarkers; Choline; Female; Humans; Hypoxia-Ischemi | 2017 |
Measurement of Lactate Content and Amide Proton Transfer Values in the Basal Ganglia of a Neonatal Piglet Hypoxic-Ischemic Brain Injury Model Using MRI.
Topics: Amides; Animals; Animals, Newborn; Basal Ganglia; Female; Hydrogen-Ion Concentration; Hypoxia-Ischem | 2017 |
The combined detection of umbilical cord nucleated red blood cells and lactate: early prediction of neonatal hypoxic ischemic encephalopathy.
Topics: Biomarkers; Case-Control Studies; Erythroblasts; Erythrocyte Count; Female; Fetal Distress; Humans; | 2008 |
A piglet model for detection of hypoxic-ischemic brain injury with magnetic resonance imaging.
Topics: Animals; Animals, Newborn; Aspartic Acid; Basal Ganglia; Brain; Brain Chemistry; Choline; Creatine; | 2008 |
Changes in cerebral oxygen consumption and high-energy phosphates during early recovery in hypoxic-ischemic piglets: a combined near-infrared and magnetic resonance spectroscopy study.
Topics: Animals; Animals, Newborn; Brain; Brain Edema; Diffusion Magnetic Resonance Imaging; Disease Models, | 2009 |
Prognostic value of proton magnetic resonance spectroscopy findings in near drowning patients: reversibility of the early metabolite abnormalities relates with a good outcome.
Topics: Child; Child, Preschool; Female; Glutamic Acid; Glutamine; Humans; Hypoxia-Ischemia, Brain; Lactic A | 2009 |
Selective cerebral perfusion: real-time evidence of brain oxygen and energy metabolism preservation.
Topics: Animals; Animals, Newborn; Cardiopulmonary Bypass; Cerebrovascular Circulation; Circulatory Arrest, | 2009 |
Evaluation of urinary S100B protein level and lactate/creatinine ratio for early diagnosis and prognostic prediction of neonatal hypoxic-ischemic encephalopathy.
Topics: Asphyxia Neonatorum; Biomarkers; Child Development; Creatinine; Developmental Disabilities; Humans; | 2010 |
Effects of hypothermia and cerebral ischemia on cold-inducible RNA-binding protein mRNA expression in rat brain.
Topics: Analysis of Variance; Animals; Brain; Cold Temperature; Disease Models, Animal; Energy Metabolism; G | 2010 |
Long-term neuroprotective effect of postischemic hypothermia in a neonatal rat model of severe hypoxic ischemic encephalopathy: a comparative study on the duration and depth of hypothermia.
Topics: Animals; Animals, Newborn; Body Temperature Regulation; Brain; Diffusion Magnetic Resonance Imaging; | 2010 |
Relation between umbilical cord blood pH, base deficit, lactate, 5-minute Apgar score and development of hypoxic ischemic encephalopathy.
Topics: Apgar Score; Carbon Dioxide; Female; Fetal Blood; Humans; Hydrogen-Ion Concentration; Hypoxia-Ischem | 2010 |
New modalities to assess efficacy of triple-h therapy: early experience.
Topics: Blood Pressure; Blood Volume; Cerebrovascular Circulation; Hemodilution; Humans; Hypoxia-Ischemia, B | 2011 |
Effects of selective head cooling on cerebral blood flow and metabolism in newborn piglets after hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Basal Metabolism; Body Temperature; Cerebral Arteries; Cerebral Cortex; C | 2011 |
Potential non-hypoxic/ischemic causes of increased cerebral interstitial fluid lactate/pyruvate ratio: a review of available literature.
Topics: Aerobiosis; Anaerobiosis; Blood Glucose; Brain; Brain Injuries; Critical Care; Energy Metabolism; Ex | 2011 |
Acid-base parameters for predicting magnetic resonance imaging measures of neurologic outcome after perinatal hypoxia-ischemia: is the strong ion gap superior to base excess and lactate?
Topics: Acid-Base Equilibrium; Acid-Base Imbalance; Brain; Cohort Studies; Female; Humans; Hypothermia, Indu | 2012 |
Cyclosporine treatment reduces oxygen free radical generation and oxidative stress in the brain of hypoxia-reoxygenated newborn piglets.
Topics: Animals; Animals, Newborn; Blood Pressure; Carotid Arteries; Cerebral Cortex; Cyclosporine; Cytochro | 2012 |
Methyl-isobutyl amiloride reduces brain Lac/NAA, cell death and microglial activation in a perinatal asphyxia model.
Topics: Amiloride; Animals; Aspartic Acid; Asphyxia; Brain; Cell Death; Disease Models, Animal; Hypoxia-Isch | 2013 |
Evidence that acidosis alters the high-affinity dopamine uptake in rat striatal slices and synaptosomes by different mechanisms partially related to oxidative damage.
Topics: Acidosis; Acidosis, Lactic; Animals; Antioxidants; Chromans; Corpus Striatum; Culture Media; Dopamin | 2003 |
Prolonged neonatal seizures exacerbate hypoxic-ischemic brain damage: correlation with cerebral energy metabolism and excitatory amino acid release.
Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Animals; Animals, Newborn; Blood Glucose; Excitatory | 2002 |
[Measurement of urinary lactate: creatine ratio for early identification of newborn infants at risk for the hypoxic-ischemic encephalopathy].
Topics: Case-Control Studies; Creatine; Female; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Lactic Aci | 2003 |
Is magnetic resonance spectroscopy superior to conventional diagnostic tools in hypoxic-ischemic encephalopathy?
Topics: Aspartic Acid; Brain; Brain Death; Cell Death; Choline; Coma; Creatine; Diffusion Magnetic Resonance | 2004 |
A newborn piglet study of moderate hypoxic-ischemic brain injury by 1H-MRS and MRI.
Topics: Animals; Animals, Newborn; Aspartic Acid; Basal Ganglia; Cerebral Cortex; Cerebrovascular Circulatio | 2004 |
Neonatal encephalopathy: association of cytokines with MR spectroscopy and outcome.
Topics: Biomarkers; Brain; Child Development; Choline; Cognition; Cytokines; Female; Humans; Hypoxia-Ischemi | 2004 |
Effect of interleukin-10 on newborn piglet brain following hypoxia-ischemia and endotoxin-induced inflammation.
Topics: Animals; Animals, Newborn; Area Under Curve; Brain; Cerebrovascular Circulation; Encephalitis; Endot | 2005 |
Elevated lactate as an early marker of brain injury in inflicted traumatic brain injury.
Topics: Aspartic Acid; Brain Chemistry; Brain Injuries; Critical Care; Female; Fractures, Bone; Frontal Lobe | 2005 |
[Value of fetal scalp lactate sampling during labour: a comparative study with scalp pH].
Topics: Adolescent; Adult; Apgar Score; Delivery, Obstetric; Female; Fetal Blood; Humans; Hydrogen-Ion Conce | 2005 |
[Urinary S100B protein and lactate/creatinine ratio measurements: a tool for the early identification of neonatal hypoxic-ischemic encephalopathy].
Topics: Apgar Score; Asphyxia Neonatorum; Creatinine; Early Diagnosis; Female; Humans; Hypoxia-Ischemia, Bra | 2005 |
Changes of lactate, glucose, ionized calcium and glutamate concentrations in cephalic vein blood during brain hypothermia using extracorporeal membrane oxygenation (ECMO) in a newborn infant with hypoxic-ischemic encephalopathy.
Topics: Blood Glucose; Brain; Calcium; Extracorporeal Membrane Oxygenation; Female; Glutamic Acid; Humans; H | 2005 |
[Effects of selective head cooling on cerebral blood flow and cerebral metabolic rate in newborn piglets].
Topics: Animals; Animals, Newborn; Blood Glucose; Brain; Cerebrovascular Circulation; Cold Temperature; Hypo | 2005 |
Lactate: creatinine ratio in babies with thin meconium staining of amniotic fluid.
Topics: Amniotic Fluid; Apgar Score; Asphyxia Neonatorum; Creatinine; Female; Gestational Age; Humans; Hypox | 2006 |
Changes in diffusion parameters, energy-related metabolites and glutamate in the rat cortex after transient hypoxia/ischemia.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Energy Metabolism; Extracellular Space; Glucose; G | 2006 |
Proton MR spectroscopy in neonates with perinatal cerebral hypoxic-ischemic injury: metabolite peak-area ratios, relaxation times, and absolute concentrations.
Topics: Aspartic Acid; Birth Injuries; Body Water; Brain; Brain Chemistry; Child Development; Choline; Creat | 2006 |
Regional metabolic status of the E-18 rat fetal brain following transient hypoxia/ischemia.
Topics: Adenosine Triphosphate; Animals; Brain; Creatine; Disease Models, Animal; Female; Fetal Hypoxia; Glu | 2006 |
The effect of cerebral hypothermia on white and grey matter injury induced by severe hypoxia in preterm fetal sheep.
Topics: Animals; Antigens, Surface; Blood Flow Velocity; Blood Glucose; Blood Pressure; Body Temperature; Br | 2007 |
Persistent lactic acidosis in neonatal hypoxic-ischaemic encephalopathy correlates with EEG grade and electrographic seizure burden.
Topics: Acidosis, Lactic; Asphyxia Neonatorum; Electroencephalography; Female; Humans; Hypoxia-Ischemia, Bra | 2008 |
Neurochemical monitoring using intracerebral microdialysis during systemic haemorrhage.
Topics: Animals; Brain; Brain Chemistry; Cerebrovascular Circulation; Disease Models, Animal; Energy Metabol | 2007 |
Prenatal cord clamping in newborn Macaca nemestrina: a model of perinatal asphyxia.
Topics: Animals; Animals, Newborn; Asphyxia; Brain; Disease Models, Animal; Electroencephalography; Erythrop | 2007 |
Xenon/hypothermia neuroprotection regimes in spontaneously breathing neonatal rats after hypoxic-ischemic insult: the respiratory and sedative effects.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Blood Glucose; Body Temperature; Carbon Dioxide; | 2008 |
Delayed hypothermia as selective head cooling or whole body cooling does not protect brain or body in newborn pig subjected to hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Anticonvulsants; Calcium; Cardiotonic Agents; Disease Models, Animal; Fem | 2008 |
Effects of fasting and insulin-induced hypoglycemia on brain cell membrane function and energy metabolism during hypoxia-ischemia in newborn piglets.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Blood Glucose; Brain; Brain Chemistry; Cell Membr | 1999 |
Predictive value of fetal scalp blood lactate concentration and pH as markers of neurologic disability.
Topics: Apgar Score; Delivery, Obstetric; Female; Fetal Blood; Humans; Hydrogen-Ion Concentration; Hypoxia-I | 1999 |
Perinatal hypoxia-ischemia and brain injury.
Topics: Humans; Hydrogen-Ion Concentration; Hypoxia-Ischemia, Brain; Infant, Newborn; Lactic Acid; Magnetic | 2000 |
Repetitive intermittent hypoxia-ischemia and brain damage in neonatal rats.
Topics: Animals; Animals, Newborn; Brain; Carotid Artery, Common; Cerebral Cortex; Corpus Striatum; Gliosis; | 2000 |
An inborn error of metabolism imitating hypoxic-ischaemic encephalopathy.
Topics: Adult; Brain Diseases, Metabolic, Inborn; Diagnosis, Differential; Fatal Outcome; Female; Fetal Hypo | 2000 |
The N-methyl-D-aspartate antagonist memantine has no neuroprotective effect during hypothermic circulatory arrest: a study in the chronic porcine model.
Topics: Animals; Behavior, Animal; Brain; Cardiopulmonary Bypass; Electroencephalography; Female; Glucose; G | 2001 |
Effects of hyperglycemia or hypoglycemia on brain cell membrane function and energy metabolism during the immediate reoxygenation-reperfusion period after acute transient global hypoxia-ischemia in the newborn piglet.
Topics: Adenosine Triphosphatases; Animals; Animals, Newborn; Asphyxia Neonatorum; Blood Gas Analysis; Blood | 2001 |
17beta-Estradiol reduces cortical lesion size in the glutamate excitotoxicity model by enhancing extracellular lactate: a new neuroprotective pathway.
Topics: Animals; Brain Injuries; Cerebral Cortex; Cerebral Infarction; Disease Models, Animal; Estradiol; Ex | 2001 |
Effect of hypothermia on brain cell membrane function and energy metabolism after transient global hypoxia-ischemia in the newborn piglet.
Topics: Animals; Animals, Newborn; Brain; Cell Membrane; Energy Metabolism; Glucose; Hypothermia, Induced; H | 2001 |
Excitotoxic preconditioning elicited by both glutamate and hypoxia and abolished by lactate transport inhibition in rat hippocampal slices.
Topics: Action Potentials; Animals; Carrier Proteins; Coumaric Acids; Excitatory Amino Acid Agonists; Glutam | 2001 |
Comparison between hypothermia and glutamate antagonism treatments on the immediate outcome of perinatal asphyxia.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Aspartic Acid; Asphyxia Neonatorum; Behavior, Ani | 2001 |
Extracellular levels of glucose and lactate measured by quantitative microdialysis in the human brain.
Topics: Blood Glucose; Brain; Brain Chemistry; Cerebrovascular Circulation; Energy Metabolism; Extracellular | 2001 |
Reduced postnatal cerebral glucose metabolism measured by PET after asphyxia in near term fetal lambs.
Topics: Acidosis; Animals; Animals, Newborn; Asphyxia Neonatorum; Blood Pressure; Cerebral Cortex; Cerebrova | 2001 |
Effect of hypoxia/hypercapnia on metabolism of 6-[(18)F]fluoro-L-DOPA in newborn piglets.
Topics: Animals; Animals, Newborn; Aromatic-L-Amino-Acid Decarboxylases; Asphyxia Neonatorum; Brain; Cardiov | 2002 |
Interleukin-10 reverses acute detrimental effects of endotoxin-induced inflammation on perinatal cerebral hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Bacterial Infections; Blood Pressure; Brain; Cerebral Palsy; Encephalitis | 2002 |