Page last updated: 2024-10-17

lactic acid and Anoxemia

lactic acid has been researched along with Anoxemia in 912 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"The purpose of the present investigation was to determine the independent effects of hypoxia and physical exercise on peripheral cholecystokinin (CCK) metabolism in humans."9.09Physical exercise and normobaric hypoxia: independent modulators of peripheral cholecystokinin metabolism in man. ( Bailey, DM; Calam, J; Castell, LM; Davies, B; Newsholme, EA, 2001)
"In this study the authors examine the effects of acute hypoxia due to extracorporeal circulation (ECC) and the role played by L-carnitine treatment on some plasmatic metabolites linked to glycolytic cellular metabolism."9.07Metabolic aspects of acute tissue hypoxia during extracorporeal circulation and their modification induced by L-carnitine treatment. ( Cogliatti, A; Corbucci, GG; Menichetti, A; Nicoli, P; Ruvolo, C, 1992)
"L-lactic acidosis (L-LA) is the most common cause of metabolic acidosis in the critical care setting, which has been associated with a large increase in mortality."9.05L-lactic acidosis: pathophysiology, classification, and causes; emphasis on biochemical and metabolic basis. ( Halperin, ML; Kamel, KS; Oh, MS, 2020)
"This study suggests that caffeic acid inhibits PHD2 enzyme activity which then activates the hypoxia-associated transcription factor HIF leading to a neuroprotective effect against hypoxia."8.12The novel prolyl hydroxylase-2 inhibitor caffeic acid upregulates hypoxia inducible factor and protects against hypoxia. ( Diao, A; Guo, B; Guo, Z; Hao, L; Li, L; Li, Y; Liu, Z; Yang, Y; Zhao, Q, 2022)
" Initial severe acidosis consisted of acute respiratory acidosis from ventilation-perfusion mismatch and acute metabolic acidosis resulting from bronchospasm and hypoxia-related lactic acidosis, respectively."8.02Salbutamol-induced lactic acidosis in status asthmaticus survivor. ( Boonkaya, S; Phoophiboon, V; Singhagowinta, P; Sriprasart, T, 2021)
"The present study is an attempt to leverage therapeutic benefits of curcumin in pulmonary hypertension by encapsulating it in biodegradable poly(lactide-co-glycolic) acid nanoparticles."7.78Tissue localization of nanoparticles is altered due to hypoxia resulting in poor efficacy of curcumin nanoparticles in pulmonary hypertension. ( Devadasu, VR; Ravi Kumar, MN; Wadsworth, RM, 2012)
" Two important determinants in this environment are hypoxia and lactic acidosis."7.74The genomic analysis of lactic acidosis and acidosis response in human cancers. ( Chen, JL; Chi, JT; Dewhirst, M; Lucas, JE; Mori, S; Nevins, J; Schroeder, T; West, M; Wu, J, 2008)
" A randomized controlled study was designed to examine the dose-response effect of dobutamine (5-20 microg x kg(-1) x min(-1)) on systemic and regional circulations and oxygen metabolism in a neonatal swine model of hypoxia/reoxygenation."7.74The hemodynamic effects of dobutamine during reoxygenation after hypoxia: a dose-response study in newborn pigs. ( Abozaid, S; Al-Salam, Z; Bigam, D; Cheung, PY; Johnson, S, 2007)
"We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model."7.73Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005)
" To gain a better understanding of the mechanisms responsible for oxygen and nutrient sensing in chondrocytes, we investigated the effects of hypoxic stimulation induced by cobalt chloride treatment (a hypoxia-mimetic) on glucose uptake and lactate production in chondrocytes."7.73Regulation of 2-deoxy-D-glucose transport, lactate metabolism, and MMP-2 secretion by the hypoxia mimetic cobalt chloride in articular chondrocytes. ( Mobasheri, A; Platt, N; Shakibaei, M; Thorpe, C, 2006)
" We hypothesized that ephedrine and phenylephrine, administered for maternal hypotension following fetal hypoxaemia, are equal in respect of fetal outcome."7.72Effects of ephedrine and phenylephrine on uterine and placental circulations and fetal outcome following fetal hypoxaemia and epidural-induced hypotension in a sheep model. ( Alahuhta, S; Erkinaro, T; Kavasmaa, T; Mäkikallio, K; Räsänen, J, 2004)
" To study the effect of acute moderate hypoxia on plasma lactic acid (LA) and lactic dehydrogenase (LDH) content in pilots."7.70[Effects of acute hypoxia on plasma lactic acid and lactic dehydrogenase content in pilots]. ( Li, WB; Liu, Y; Qin, SZ, 2000)
"The influence of systemic hypoxia on lactate and adenosine output from isolated constant-flow-perfused gracilis muscle was determined in anesthetized dogs."7.69Intracellular lactate controls adenosine output from dog gracilis muscle during moderate systemic hypoxia. ( Ballard, HJ; Mo, FM, 1997)
"The role of inhibition of the CPT enzymes responsible for accumulation of long chain acylcarnitines (LCAC) during hypoxia in the proximal tubule has not been previously examined."7.69Carnitine palmitoyl-transferase enzyme inhibition protects proximal tubules during hypoxia. ( Portilla, D, 1997)
"We tested whether digoxin would limit tissue hypoxia during severe anemia by improving peripheral O2 distribution or decreasing O2 demands."7.68Oxygen transport during anemic hypoxia in pigs: effects of digoxin on metabolism. ( Hendler, R; Lister, G; Saltiel, A; Sanfilippo, DJ, 1992)
"The relationships between the concentrations of glycogen, glucose, lactate, adenosine triphosphate (ATP) and hypoxanthine in the brain tissue, and the hypoxanthine and lactate concentration in cerebrospinal fluid and blood were examined after exposure of rats to hypoxia."7.67Concentration of hypoxanthine in both cerebrospinal fluid and brain tissue increases under intensive hypoxia only. ( Gross, J; Lun, A; Pohle, R; Siggel, H, 1988)
"The role of lactic acidosis of progressive brain hypoxia (PBH) as both a central chemoreceptor stimulant and a general respiratory depressant was assessed by preventing lactate formation both locally and globally with dichloroacetate (DCA)."7.67Role of brain lactic acidosis in hypoxic depression of respiration. ( Edelman, NH; Neubauer, JA; Simone, A, 1988)
"To determine the suitability of plasma hypoxanthine as a marker of tissue hypoxia, we studied the relationship of arterial plasma hypoxanthine and blood lactate concentrations to the cumulative O2 deficit during hypoxemia and low cardiac output (hypoxic and stagnant hypoxia, respectively)."7.67Hypoxanthine and lactate concentrations in lambs during hypoxic and stagnant hypoxia. ( Kurzner, S; Lister, G; Moss, M; Razlog, Y, 1988)
"Hypoxic lactic acidosis (HLA) was induced in dogs by ventilating them with a hypoxic gas mixture of 8% O2-92% N2."7.67Pathophysiology of type A hypoxic lactic acidosis in dogs. ( Arieff, AI; Graf, H, 1987)
"To test the hypothesis that adenosine is required to mediate the coronary vasodilative response to acute hypoxia haemodynamic indices, regional myocardial blood flow, and oxygen and lactate metabolism were measured in nine closed chest anaesthetised domestic swine at control, after 3-5 min of 100% nitrogen inhalation, at second control, and after 3-5 min of 100% nitrogen inhalation plus adenosine deaminase infusion in the left anterior descending coronary artery."7.67Role of adenosine in mediating the coronary vasodilative response to acute hypoxia. ( Gewirtz, H; Most, AS; Olsson, RA, 1987)
"Experimental factors implicated in the pathogenesis of halothane hepatotoxicity in the phenobarbital-hypoxia rat model were examined for direct effects on the energy status of isolated rat liver cells in vitro."7.67Energy deficits in hepatocytes isolated from phenobarbital-treated or fasted rats and briefly exposed to halothane and hypoxia in vitro. ( Albrecht, RF; Becker, GL; Hensel, P; Holland, AD; Miletich, DJ, 1986)
"The effect of hypoxia on the elimination of omeprazole, a potent inhibitor of gastric acid secretion, was studied in the isolated perfused rat liver."7.67Effect of hypoxia on oxidative and reductive pathways of omeprazole metabolism by the isolated perfused rat liver. ( Jones, DB; Mihaly, GW; Morgan, DJ; Smallwood, RA; Webster, LK, 1985)
"In mice, changes of body temperature and concentration of lactic acid in the blood were studied after three modes of barochamber hypoxia (altitude 8000 m) at the temperatures +10, +20 and +36 degrees C."7.67[Effect of short-term hypoxia on body temperature and lactic acid in the blood of the mouse]. ( Pisarenko, SN; Sepisheva, AS; Slonim, AD, 1985)
"The possibility of detecting past hypoxia during the first 2 h after birth by means of blood analyses of hypoxanthine, lactate, base deficit, and pH was investigated in six infants with a 1 min Apgar score of less than or equal to 4."7.66Hypoxanthine as a test of perinatal hypoxia as compared to lactate, base deficit, and pH. ( Bratteby, LE; Swanström, S, 1982)
"During prolonged anoxia at low temperature, freshwater turtles develop high plasma concentrations of both lactate and calcium."6.42Surviving extreme lactic acidosis: the role of calcium lactate formation in the anoxic turtle. ( Jackson, DC, 2004)
"This study demonstrates that acute high altitude hypoxia upregulated the lactic acid/amino acid-pyruvate-TCA pathways and fatty acid oxidation, but downregulated glycolysis in the liver of mice."5.91Energy metabolic mechanisms for high altitude sickness: Downregulation of glycolysis and upregulation of the lactic acid/amino acid-pyruvate-TCA pathways and fatty acid oxidation. ( Jiang, C; Li, Y; Liao, N; Liu, G; Shang, X; Shao, D; Shi, J; Xu, F; Yin, D, 2023)
"Ischemia was followed by a significant increase in muscle myeloperoxidase activity, as well as interleukin-6 and thiobarbituric acid reactive substances species levels."5.48N-acetylcysteine effects on a murine model of chronic critical limb ischemia. ( Constantino, L; da Silva, LA; Dal-Pizzol, F; Dall'Igna, DM; de Medeiros, WA; Dos Santos Cardoso, J; Manfredini, A; Michels, M; Ritter, C; Scaini, G; Streck, EL; Vuolo, F, 2018)
"High uric acid (UA) has been found to be correlated with renal dysfunction in some experimental and clinical studies; however, the study of the dynamic correlation between AKI and UA in severe burns is still lacking."5.42Elevated serum uric acid after injury correlates with the early acute kidney in severe burns. ( Hu, X; Liang, J; Zhang, P; Zhi, L, 2015)
"Adenosine is a product of adenylate phosphate breakdown that can exert protective effects on tissues during energy limitation."5.32Cardiorespiratory and tissue adenosine responses to hypoxia and reoxygenation in the short-horned sculpin Myoxocephalus scorpius. ( Driedzic, WR; Maccormack, TJ, 2004)
"During sow parturition, there is need for an alternative uterotonic to oxytocin with less potency so piglets are not at risk of hypoxia and stillbirth."5.30Effects of oxytocin and carbetocin on farrowing performance. ( Kirkwood, RN; Plush, KL; Ward, SA, 2019)
"To evaluate the effect of hypoxemia on cardiac release of neuropeptide Y-like immunoreactivity (NPY-LI) and norepinephrine (NE), arterial and coronary sinus blood was sampled and coronary sinus blood flow was measured by thermodilution in nine healthy volunteers at rest and during supine cycle ergometer exercise while they breathed air and 12% O2, which reduced arterial O2 saturation to approximately 68%."5.29Neuropeptide Y release from human heart is enhanced during prolonged exercise in hypoxia. ( Berglund, B; Grubbström, J; Kaijser, L; Lundberg, JM; Pernow, J, 1994)
"During CO2 acidosis, anoxia had no effect on apparent nonbicarbonate buffer value (d[HCO3-]/dpHi = 71 and 89 mM/pH in normoxia and anoxia, respectively) or on pHi regulation (dpHi/dpHe = 0."5.2831P-NMR study of normoxic and anoxic perfused turtle heart during graded CO2 and lactic acidosis. ( Arendt, EA; Inman, KC; Jackson, DC; Lawler, RG; Panol, G; Wasser, JS, 1991)
"The purpose of the present investigation was to determine the independent effects of hypoxia and physical exercise on peripheral cholecystokinin (CCK) metabolism in humans."5.09Physical exercise and normobaric hypoxia: independent modulators of peripheral cholecystokinin metabolism in man. ( Bailey, DM; Calam, J; Castell, LM; Davies, B; Newsholme, EA, 2001)
"In this study the authors examine the effects of acute hypoxia due to extracorporeal circulation (ECC) and the role played by L-carnitine treatment on some plasmatic metabolites linked to glycolytic cellular metabolism."5.07Metabolic aspects of acute tissue hypoxia during extracorporeal circulation and their modification induced by L-carnitine treatment. ( Cogliatti, A; Corbucci, GG; Menichetti, A; Nicoli, P; Ruvolo, C, 1992)
"L-lactic acidosis (L-LA) is the most common cause of metabolic acidosis in the critical care setting, which has been associated with a large increase in mortality."5.05L-lactic acidosis: pathophysiology, classification, and causes; emphasis on biochemical and metabolic basis. ( Halperin, ML; Kamel, KS; Oh, MS, 2020)
" anaerobic glycolysis sustaining ATP production in supramaximal exercise as well as in conditions of hypoxia and ischemia, is responsible for the accumulation of large amounts of lactic acid (up to 1 mol for the whole body)."4.82Acid-base balance at exercise in normoxia and in chronic hypoxia. Revisiting the "lactate paradox". ( Cerretelli, P; Samaja, M, 2003)
" These factors (immaturity, hyperoxia, hypoxia, blood transfusions, intraventricular hemorrhage, apnea, infection, hypercarbia, hypocarbia, patent ductus arteriosus, prostaglandin synthetase inhibitors, vitamin E deficiency, lactic acidosis, prenatal complications, genetic factors) may all be present in an infant."4.76A reexamination of the role of oxygen in retrolental fibroplasia. ( Dangman, B; Lucey, JF, 1984)
" MCT4 is associated with the export of lactic acid from cancer cells under hypoxia, so inhibition of MCT4 may lead to cytotoxic levels of intracellular lactate."4.31Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology. ( Beattie, D; Buttar, D; Clark, R; Cook, CR; Critchlow, SE; Goldberg, FW; Hopcroft, L; Hughes, G; Kavanagh, SL; Kawatkar, A; Kettle, JG; Komen, JC; Lamont, GM; McGuire, TM; Morentin Gutierrez, P; Ting, AKT, 2023)
" As S-adenosylhomocysteine (SAH) was shown to reflect tissue hypoxia, we compared the ability of SAH versus lactate to predict the progression of inflammatory and septic disease to septic organ dysfunction and death."4.31S-Adenosylhomocysteine Is a Useful Metabolic Factor in the Early Prediction of Septic Disease Progression and Death in Critically Ill Patients: A Prospective Cohort Study. ( Brohm, K; Centner, FS; Fuderer, T; Hahn, B; Jäger, E; Krebs, J; Lindner, HA; Mindt, S; Neumaier, M; Schneider-Lindner, V; Schoettler, JJ; Thiel, M, 2023)
" Acute poisoning occurred after taking 100 ml of 1,4-butanediol together with phenyl-2- (1-pyrrolidinyl) -1-pentanone and 2 g of methadone, clinically manifested in the form of convulsive syndrome, depression of consciousness to the level of coma 3, edema and swelling brain, acute respiratory failure, mixed decompensated respiratory and metabolic lactic acidosis (pH 7."4.12[CLINICAL CASE OF ACUTE SEVERE COMBINED POISONING WITH NARCOTIC SUBSTANCES OF DEPENDENT AND PSYCHOSTIMULATING EFFECTS]. ( Antonova, A; Batotsyrenov, B; Kovalenko, A; Lodyagin, A; Loladze, A; Sinenchenko, A, 2022)
"This study suggests that caffeic acid inhibits PHD2 enzyme activity which then activates the hypoxia-associated transcription factor HIF leading to a neuroprotective effect against hypoxia."4.12The novel prolyl hydroxylase-2 inhibitor caffeic acid upregulates hypoxia inducible factor and protects against hypoxia. ( Diao, A; Guo, B; Guo, Z; Hao, L; Li, L; Li, Y; Liu, Z; Yang, Y; Zhao, Q, 2022)
"Hypoxia and high accumulation of lactic acid in the tumor microenvironment provide fertile soil for tumor development, maintenance and metastasis."4.12Acidic and hypoxic tumor microenvironment regulation by CaO ( Chang, J; Dong, H; Li, Y; Liu, Y; Ma, X; Ren, T; Ruan, S; Sun, J; Yang, Y; Yin, W; Zang, J, 2022)
" Initial severe acidosis consisted of acute respiratory acidosis from ventilation-perfusion mismatch and acute metabolic acidosis resulting from bronchospasm and hypoxia-related lactic acidosis, respectively."4.02Salbutamol-induced lactic acidosis in status asthmaticus survivor. ( Boonkaya, S; Phoophiboon, V; Singhagowinta, P; Sriprasart, T, 2021)
"The pathological expression and function of lactate dehydrogenase A (LDHA), a key enzyme that converts pyruvate into lactic acid during glycolysis, remains unknown in endometriosis."4.02Hypoxia‑induced lactate dehydrogenase A protects cells from apoptosis in endometriosis. ( Dai, Y; Huang, Q; Jin, X; Lin, X; Liu, N; Shi, L; Zhang, S; Zheng, J; Zhou, F, 2021)
"In this study, C57BL/6 J mice were administrated with an Nrf2 activator, sulforaphane (SFN) before taking incremental treadmill exercise to exhaustion under hypoxia; then the effects of SFN on exercise endurance and molecular/biochemical makers of the skeletal muscle were evaluated."3.96Nrf2 Activation Enhances Muscular MCT1 Expression and Hypoxic Exercise Capacity. ( Wang, J; Wang, L; Yu, S; Zhang, Y; Zhu, R, 2020)
" The effects of different doses of FOPS on the loaded-swimming time, the content of serum urea nitrogen, the blood lactic acid, the hepatic glycogen and the muscle glycogen after exercise, the survival time under hypoxia at normal pressure and the maintenance time after decapitation were observed."3.91[Effects of the Fomes officinalis Ames. polysaccharides on anti-fatigue and hypoxia tolerance in mice]. ( Hao, HY; Sha, AL, 2019)
"The effect of lactic acidosis on neurological development in the first year of life."3.88Neurological impairments in hypoxic neonates and lactate levels. ( Jovandaric, MZ; Milenkovic, SJ, 2018)
"We evaluated the influence of hypoxic hypoxia on lactate, creatinine and urea concentrations in the amniotic fluid (AF) of rabbits on 27-28th day of pregnancy."3.85[Acute hypoxic hypoxia increases lactate concentration in amniotic fluid of rabbits on 27-28th day of pregnancy]. ( Korenovsky, YV; Popovtseva, AV; Suzopov, EV, 2017)
" Biotin-deficient rats show a syndrome characterized by marked weight loss, metabolic lactic acidosis, aciduria and accelerated breathing with normal responsiveness to hypoxia."3.83Selective accumulation of biotin in arterial chemoreceptors: requirement for carotid body exocytotic dopamine secretion. ( Arias-Mayenco, I; Bonilla-Henao, V; González-Rodríguez, P; Levitsky, KL; López-Barneo, J; Macías, D; Ortega-Sáenz, P; Rodríguez-Gómez, JA, 2016)
"This study evaluated the effects of thiamine pyrophosphate (PPT) on the biochemical profiles of full-term rabbit foetuses that were subjected to experimental ischemia followed by 24h reperfusion."3.83Evaluation of the protective effect of thiamine pyrophosphate based on the biochemical analysis of rabbit foetuses at 30 days of gestation. ( Alonso-Spilsbury, M; Arch-Tirado, E; Jiménez-Bravo, MA; Martínez-Burnes, J; Mora-Medina, P; Mota-Rojas, D; Orozco-Gregorio, H; Pérez-Guille, B; Roldan-Santiago, P; Soriano-Rosales, R, 2016)
"In this study, blood redox potential (ORP) values (ΔORP value was adopted, as the quantitative index to reflect the overall redox status), plasma uric acid levels (important antioxidant, as antioxidant index), and the burn shock state-related indicators (lactic acid and hematocrit) of 48 burn patients were dynamically, quantitatively monitored during the early stage after injury."3.81The characteristics and correlation between the ischemia-reperfusion and changes of redox status in the early stage of severe burns. ( Han, C; Hu, H; Hu, X; Pan, X; Shao, H; Xu, J; Yu, C; Zhi, L, 2015)
" These measurements indicate that apoptosis was the primary mechanism of cell death; acidity was not caused by lactic acid; and cell death was caused by depletion of carbon sources and not hypoxia."3.80Rapid uptake of glucose and lactate, and not hypoxia, induces apoptosis in three-dimensional tumor tissue culture. ( Forbes, NS; Kasinskas, RW; Venkatasubramanian, R, 2014)
"The present study is an attempt to leverage therapeutic benefits of curcumin in pulmonary hypertension by encapsulating it in biodegradable poly(lactide-co-glycolic) acid nanoparticles."3.78Tissue localization of nanoparticles is altered due to hypoxia resulting in poor efficacy of curcumin nanoparticles in pulmonary hypertension. ( Devadasu, VR; Ravi Kumar, MN; Wadsworth, RM, 2012)
" In the present study, both afferent nerves and either of them were activated by muscle contraction, passive tendon stretch, and arterial injection of lactic acid into the hindlimb muscles."3.78Role for NGF in augmented sympathetic nerve response to activation of mechanically and metabolically sensitive muscle afferents in rats with femoral artery occlusion. ( Li, J; Lu, J; Xing, J, 2012)
"The effectiveness of sodium bicarbonate (SB) has recently been questioned although it is often used to correct metabolic acidosis of neonates."3.78Infusing sodium bicarbonate suppresses hydrogen peroxide accumulation and superoxide dismutase activity in hypoxic-reoxygenated newborn piglets. ( Bigam, DL; Cheung, PY; Lee, TF; Liu, JQ; Manouchehri, N; Yao, M, 2012)
"Intraluminal microdialysis revealed signs of intestinal hypoxia and cellular damage, with a marked increase of lactate and glycerol."3.78Intraluminal intestinal microdialysis detects markers of hypoxia and cell damage in experimental necrotizing enterocolitis. ( Carlsson, PO; Hillered, L; Högberg, N; Lilja, HE; Stenbäck, A, 2012)
"Nude mice bearing FaDu, UT-SCC-15, and UT-SCC-5 hSCC were injected with pimonidazole hypoxia and Hoechst perfusion markers."3.75Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts. ( Baumann, M; Meyer, S; Mueller-Klieser, W; Quennet, V; Shakirin, G; Walenta, S; Yaromina, A; Zips, D, 2009)
", samples with HMGB-1 levels >2 SD above the mean level in samples from patients with noninflammatory arthropathy), concentrations of HMGB-1 were significantly correlated with those of lactic acid, a marker of tissue hypoxia."3.74Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis. ( Abeyama, K; Fukuda, T; Fukuzaki, K; Hamada, T; Hashiguchi, K; Horai, N; Komiya, S; Kuwazuru, A; Maruyama, I; Nagata, R; Nagayama, S; Sunahara, N; Tanaka, M; Torikai, M; Yamada, S, 2008)
"Phosphocreatine (PCr) was reduced to equivalent levels in carp white muscle by high-intensity exhaustive exercise and exposure to hypoxia at 15 degrees C and 25 degrees C in order to assess the influence of intracellular pH (pH(i)), temperature and lactate levels on PCr recovery in vivo."3.74Differential recovery from exercise and hypoxia exposure measured using 31P- and 1H-NMR in white muscle of the common carp Cyprinus carpio. ( Hallman, TM; Jones, DR; Richards, JG; Rojas-Vargas, AC, 2008)
" Two important determinants in this environment are hypoxia and lactic acidosis."3.74The genomic analysis of lactic acidosis and acidosis response in human cancers. ( Chen, JL; Chi, JT; Dewhirst, M; Lucas, JE; Mori, S; Nevins, J; Schroeder, T; West, M; Wu, J, 2008)
" Tissue glucose uptake and cardiovascular characteristics were measured in the short-horned sculpin, Myoxocephalus scorpius, a species exhibiting low blood glucose levels, during normoxia and hypoxia to assess the role of adenosine receptors in the control of glucose uptake and anaerobic metabolism."3.74The impact of hypoxia on in vivo glucose uptake in a hypoglycemic fish, Myoxocephalus scorpius. ( Driedzic, WR; MacCormack, TJ, 2007)
" Our results demonstrate that 1) males sustain isometric force production (F) longer than females under hyperoxia (P O2 = 640 mmHg) with exogenous glucose present; 2) contractility is not maintained under moderate (P O2 = 130 mmHg) or severe hypoxia (P O2 = 10-20 mmHg) with glucose in either sex; however, following reoxygenation, F is higher in females compared with males; and 3) female tissue has higher lactate levels, net lactate efflux, and lactate dehydrogenase activity than males, whereas males have higher glycogen, citrate synthase, and beta-hydroxy acyl-CoA dehydrogenase activities, and greater inotropic responses to exogenous glucose and octanoate."3.74Sex differences in energy metabolism and performance of teleost cardiac tissue. ( Battiprolu, PK; Harmon, KJ; Rodnick, KJ, 2007)
" Taurine may have been released by the tissues as a protective mechanism against hypoxia-induced inflammation, or in an attempt to maintain osmotic balance."3.74Taurine as a marker for foetal wellbeing? ( de Boo, HA; Harding, JE, 2007)
" A randomized controlled study was designed to examine the dose-response effect of dobutamine (5-20 microg x kg(-1) x min(-1)) on systemic and regional circulations and oxygen metabolism in a neonatal swine model of hypoxia/reoxygenation."3.74The hemodynamic effects of dobutamine during reoxygenation after hypoxia: a dose-response study in newborn pigs. ( Abozaid, S; Al-Salam, Z; Bigam, D; Cheung, PY; Johnson, S, 2007)
" Extracellular pH defense against lactic acidosis was estimated from changes (Delta) in lactic acid ([La]), [HCO3-], pH and PCO2 in plasma, which equilibrates with interstitial fluid."3.74Extracellular pH defense against lactic acid in untrained and trained altitude residents. ( Böning, D; Coy, L; Mora, M; Reyes, O; Rojas, J; Serrato, M, 2008)
"We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model."3.73Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005)
"Acute hypoxia increases cerebral lactate and alanine in NG chick embryos; these increases are reduced by pre-exposure to substrate deprivation and chronic hypoxia."3.73Growth restriction and the cerebral metabolic response to acute hypoxia of chick embryos in-ovo: a proton magnetic resonance spectroscopy study. ( Cady, EB; Dixon, JC; Peebles, DM; Priest, AN; Thornton, JS, 2005)
" This effect disappeared, however, when hypoxia was combined with acidosis obtained by 24 mM lactic acid."3.73Force development at elevated [Mg2+]o and [K+]o in myocardium from the freshwater turtle (Trachemys scripta) and influence of factors associated with hibernation. ( Gesser, H, 2006)
" To gain a better understanding of the mechanisms responsible for oxygen and nutrient sensing in chondrocytes, we investigated the effects of hypoxic stimulation induced by cobalt chloride treatment (a hypoxia-mimetic) on glucose uptake and lactate production in chondrocytes."3.73Regulation of 2-deoxy-D-glucose transport, lactate metabolism, and MMP-2 secretion by the hypoxia mimetic cobalt chloride in articular chondrocytes. ( Mobasheri, A; Platt, N; Shakibaei, M; Thorpe, C, 2006)
" Incubation at hypoxia resulted in increased lactate concentrations, whereas ATP, glucose, and glycogen concentrations were decreased, especially in the mid media, where concentrations of these metabolites were close to zero."3.72Mapping of ATP, glucose, glycogen, and lactate concentrations within the arterial wall. ( Björnheden, T; Bondjers, G; Evaldsson, M; Leppänen, O; Levin, M; Wiklund, O, 2003)
" We conclude that caiman osteoderms sequester lactate during lactic acidosis and that the time course is fast enough to have benefit to these animals following normal anaerobic burst activity."3.72Lactate sequestration by osteoderms of the broad-nose caiman, Caiman latirostris, following capture and forced submergence. ( Abe, AS; Andrade, DV; Jackson, DC, 2003)
" The addition of the glucose transporter inhibitor cytochalasin B caused hypoxic hearts to fail early, and hearts perfused with a glucose analogue, 2-deoxyglucose (2-DG), increased glucose uptake 3-fold under hypoxia."3.72The regulation and importance of glucose uptake in the isolated Atlantic cod heart: rate-limiting steps and effects of hypoxia. ( Clow, KA; Driedzic, WR; MacCormack, TJ; Rodnick, KJ, 2004)
" We hypothesized that ephedrine and phenylephrine, administered for maternal hypotension following fetal hypoxaemia, are equal in respect of fetal outcome."3.72Effects of ephedrine and phenylephrine on uterine and placental circulations and fetal outcome following fetal hypoxaemia and epidural-induced hypotension in a sheep model. ( Alahuhta, S; Erkinaro, T; Kavasmaa, T; Mäkikallio, K; Räsänen, J, 2004)
" Hypoxia induced an immediate and significant elevation in the intraperitoneal lactate/pyruvate ratio to 446+/-137% of the baseline values, and glycerol subsequently increased during reoxygenation to 389+/-109%."3.71Intraperitoneal microdialysis for detection of splanchnic metabolic disorders. ( Bahlmann, L; Bruch, HP; Gliemroth, J; Heringlake, M; Klaus, S, 2002)
" Under conditions of acute hypoxia induced by breathing carbon monoxide at 660 ppm, the apparent glycolytic rate was 0."3.71Effect of changing tumor oxygenation on glycolytic metabolism in a murine C3H mammary carcinoma assessed by in vivo nuclear magnetic resonance spectroscopy. ( Bentzen, L; Daugaard, P; Horsman, MR; Maxwell, RJ; Nielsen, FU; Overgaard, J; Stødkilde-Jørgensen, H, 2001)
" Hyperlactatemia with L/P ratio elevation and lactic acidosis is likely to be associated with inadequate tissue perfusion."3.70Time-pattern of lactate and lactate to pyruvate ratio in the first 24 hours of intensive care emergency admissions. ( Kari, A; Ruokonen, E; Suistomaa, M; Takala, J, 2000)
"We investigated the metabolic effects of buffering agents alpha-amino-4-imidazole-propionic acid (Histidine), N, N-bis(2-hydroxyethyl)glycine (bicine), N, N-bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES) on anaerobic energy production (via glycolysis) and conservation of key regulatory enzyme activity, and phosphofructokinase (PFK) throughout prolonged hypothermic hypoxia in porcine hearts."3.70Conservation of phosphorylation state of cardiac phosphofructokinase during in vitro hypothermic hypoxia. ( Churchill, TA; Kneteman, NM; Pulis, RP; Wu, BM, 2000)
" To study the effect of acute moderate hypoxia on plasma lactic acid (LA) and lactic dehydrogenase (LDH) content in pilots."3.70[Effects of acute hypoxia on plasma lactic acid and lactic dehydrogenase content in pilots]. ( Li, WB; Liu, Y; Qin, SZ, 2000)
"This study examines the neonatal response to graded hypoxia and determines the arterial PO2 (PaO2) threshold for oxygen-restricted metabolism as confirmed by the development of lactic acidosis and altered oxygen handling."3.69Blood lactate and acid-base balance in graded neonatal hypoxia: evidence for oxygen-restricted metabolism. ( Torrance, SM; Wittnich, C, 1994)
"Isovolumetric rat hearts (37 degrees C) were treated with 1 microM (apri 1) or 30 microM (apri 30) aprikalim, or preconditioned with either 10 min of hypoxia (N2PC) or 5 min of ischaemia followed by 5 min of perfusion (IPC5) or 10 min of ischaemia followed by 3 min of perfusion (IPC10)."3.69Comparison of effects of aprikalim and of hypoxic and ischaemic preconditioning on extracellular potassium accumulation, metabolism, and functional recovery of the globally ischaemic rat heart. ( Diacono, J; Feuvray, D; Guo, AC, 1994)
"The present study was designed to determine whether lactate changes the critical pH point at which the recovery of rat population spike is inhibited following glucose-oxygen deprivation and second, which degree of lactic acidosis is similar to the effect of CO2 acidosis."3.69Effect of lactic and CO2 acidosis on neuronal function following glucose-oxygen deprivation in rat hippocampal slices. ( Kemmotsu, O; Morimoto, Y, 1994)
"The goal of this study was to evaluate whether sodium bicarbonate might be a useful form of therapy for hypoxic L-lactic acidosis; our aim was to determine if alkali could extend the time of survival in this setting."3.69Alkali therapy extends the period of survival during hypoxia: studies in rats. ( Cheema-Dhadli, S; Chen, CB; Halperin, FA; Halperin, ML, 1996)
"The influence of systemic hypoxia on lactate and adenosine output from isolated constant-flow-perfused gracilis muscle was determined in anesthetized dogs."3.69Intracellular lactate controls adenosine output from dog gracilis muscle during moderate systemic hypoxia. ( Ballard, HJ; Mo, FM, 1997)
"In isovolumically perfused Langendorff heart preparations of guinea pigs adenosine-depending on the experimental protocol-more or less could prevent the hypoxia-induced decrease in myocardial adenosine triphosphate [ATP], creatine phosphate [CP], glycogen and increase in lactate, i."3.69On the cardioprotective effect of adenosine. ( Kovács, P; Nosztray, K; Szabó, JZ; Szegi, J; Szentmiklósi, AJ; Ujfalusi, A; Varga, E, 1996)
"The role of inhibition of the CPT enzymes responsible for accumulation of long chain acylcarnitines (LCAC) during hypoxia in the proximal tubule has not been previously examined."3.69Carnitine palmitoyl-transferase enzyme inhibition protects proximal tubules during hypoxia. ( Portilla, D, 1997)
"Experiments are described in which a rat hippocampal slice preparation was used along with the metabolic glial inhibitor, fluorocitrate (FC), to investigate the role of glial-made lactate and its shuttling to neurons in posthypoxia recovery of synaptic function."3.69Glia are the main source of lactate utilized by neurons for recovery of function posthypoxia. ( Miller, JJ; Payne, RS; Rigor, BM; Schurr, A, 1997)
" The application of cyanide (to mimic hypoxia) produced a fall of the concentration of phosphocreatine ([PCr]) and a rise of those of inorganic phosphate ([Pi]) and sugar phosphates."3.68Relationship between intracellular pH and metabolite concentrations during metabolic inhibition in isolated ferret heart. ( Bauer, CJ; Donoso, P; Eisner, DA; Smith, GL, 1993)
"Flux through the adenosine production and degradation pathways is transiently increased during hypoxia."3.68Interstitial purine metabolites and lactate during regional myocardial hypoxia. ( Downey, HF; Van Wylen, DG; Williams, AG, 1993)
"We tested the hypotheses that in newborn piglets indomethacin (Indo) pretreatment blunts the hyperemic brain blood flow (BF) and alters the cerebral metabolic responses to hypoxia and that these responses are dose dependent."3.68Effects of indomethacin on brain blood flow and cerebral metabolism in hypoxic newborn piglets. ( Coyle, MG; Oh, W; Stonestreet, BS, 1993)
"Previous studies in this laboratory showed that hypoxia and anoxia enhance the susceptibility of hepatocytes to tert-butylhydroperoxide (TBH)-induced oxidative injury."3.68Postanoxic oxidative injury in rat hepatocytes: lactate-dependent protection against tert-butylhydroperoxide. ( Aw, TY; Jones, DP; Kowalski, DP; Park, Y, 1992)
"Lactic acid, the end metabolic product of anaerobic glycolysis is probably the mediator of the hypoxia induced vasodilation on retinal arterioles."3.68[Metabolic factors of vasomotor regulation of the inner retina]. ( Brazitikos, PD; Munoz, JL; Pournaras, CJ; Tsacopoulos, M, 1992)
"We tested whether digoxin would limit tissue hypoxia during severe anemia by improving peripheral O2 distribution or decreasing O2 demands."3.68Oxygen transport during anemic hypoxia in pigs: effects of digoxin on metabolism. ( Hendler, R; Lister, G; Saltiel, A; Sanfilippo, DJ, 1992)
" We hypothesized that the lactic acidosis associated with prolonged systemic hypoxemia might mediate the adaptation of the hypoxemic inhibition of FBM."3.68Vascular lactic acid infusions do not alter the incidence of fetal breathing movements or their inhibition by acute hypoxemia. ( Bissonnette, JM; Hohimer, AR, 1991)
"In the rat vas deferens (preloaded with 3H-noradrenaline, catechol-O-methyl transferase inhibited, calcium-free solution) ouabain, glucose deprivation or the combination of hypoxia plus presence of lactate were found to induce a carrier-mediated (desipramine-sensitive) outward transport of the 3H-amine."3.68The energy requirements for the basal efflux of 3H-noradrenaline from sympathetically innervated organs. ( Russ, H; Schömig, E; Trendelenburg, U, 1991)
" To study this problem, acute isocapnic metabolic acidosis was induced by HCl or lactic acid infusions in rats, and recovery from acidosis was accomplished by NaHCO3 infusion."3.68Brain pH in acute isocapnic metabolic acidosis and hypoxia: a 31P-nuclear magnetic resonance study. ( Adler, S; Ho, C; Simplaceanu, V, 1990)
"88 mM Amytal (amobarbital), hypoxia (95% N2-5% CO2), or 12 microM adenosine in the presence and absence of 2."3.67Relationship of myocardial metabolism and coronary flow: dependence on extracellular calcium. ( Erecińska, M; Rumsey, WL; Wilson, DF, 1987)
" We studied the effects of carbicarb in an animal preparation of hypoxic lactic acidosis (HLA)."3.67Improved hemodynamic function during hypoxia with Carbicarb, a new agent for the management of acidosis. ( Arieff, AI; Bersin, RM, 1988)
"The relationships between the concentrations of glycogen, glucose, lactate, adenosine triphosphate (ATP) and hypoxanthine in the brain tissue, and the hypoxanthine and lactate concentration in cerebrospinal fluid and blood were examined after exposure of rats to hypoxia."3.67Concentration of hypoxanthine in both cerebrospinal fluid and brain tissue increases under intensive hypoxia only. ( Gross, J; Lun, A; Pohle, R; Siggel, H, 1988)
"The role of lactic acidosis of progressive brain hypoxia (PBH) as both a central chemoreceptor stimulant and a general respiratory depressant was assessed by preventing lactate formation both locally and globally with dichloroacetate (DCA)."3.67Role of brain lactic acidosis in hypoxic depression of respiration. ( Edelman, NH; Neubauer, JA; Simone, A, 1988)
"To determine the suitability of plasma hypoxanthine as a marker of tissue hypoxia, we studied the relationship of arterial plasma hypoxanthine and blood lactate concentrations to the cumulative O2 deficit during hypoxemia and low cardiac output (hypoxic and stagnant hypoxia, respectively)."3.67Hypoxanthine and lactate concentrations in lambs during hypoxic and stagnant hypoxia. ( Kurzner, S; Lister, G; Moss, M; Razlog, Y, 1988)
"Hypoxic lactic acidosis (HLA) was induced in dogs by ventilating them with a hypoxic gas mixture of 8% O2-92% N2."3.67Pathophysiology of type A hypoxic lactic acidosis in dogs. ( Arieff, AI; Graf, H, 1987)
"To test the hypothesis that adenosine is required to mediate the coronary vasodilative response to acute hypoxia haemodynamic indices, regional myocardial blood flow, and oxygen and lactate metabolism were measured in nine closed chest anaesthetised domestic swine at control, after 3-5 min of 100% nitrogen inhalation, at second control, and after 3-5 min of 100% nitrogen inhalation plus adenosine deaminase infusion in the left anterior descending coronary artery."3.67Role of adenosine in mediating the coronary vasodilative response to acute hypoxia. ( Gewirtz, H; Most, AS; Olsson, RA, 1987)
" Reduced ATP and phosphocreatine content, intracellular acidosis related to hypercapnia, increased muscle lactate without alterations of the muscle lactate concentration gradient were observed in the skeletal muscle of the hypercapnic-hypoxemic COPD patients studied, in which group no correlation was found between hypoxia and energy or lactate metabolism parameters."3.67Skeletal muscle energetics, acid-base equilibrium and lactate metabolism in patients with severe hypercapnia and hypoxemia. ( Coffrini, E; Del Canale, S; Fiaccadori, E; Guariglia, A; Ronda, N; Vitali, P, 1987)
"Experimental factors implicated in the pathogenesis of halothane hepatotoxicity in the phenobarbital-hypoxia rat model were examined for direct effects on the energy status of isolated rat liver cells in vitro."3.67Energy deficits in hepatocytes isolated from phenobarbital-treated or fasted rats and briefly exposed to halothane and hypoxia in vitro. ( Albrecht, RF; Becker, GL; Hensel, P; Holland, AD; Miletich, DJ, 1986)
"The effect of hypoxia on the elimination of omeprazole, a potent inhibitor of gastric acid secretion, was studied in the isolated perfused rat liver."3.67Effect of hypoxia on oxidative and reductive pathways of omeprazole metabolism by the isolated perfused rat liver. ( Jones, DB; Mihaly, GW; Morgan, DJ; Smallwood, RA; Webster, LK, 1985)
"In mice, changes of body temperature and concentration of lactic acid in the blood were studied after three modes of barochamber hypoxia (altitude 8000 m) at the temperatures +10, +20 and +36 degrees C."3.67[Effect of short-term hypoxia on body temperature and lactic acid in the blood of the mouse]. ( Pisarenko, SN; Sepisheva, AS; Slonim, AD, 1985)
"The possibility of detecting past hypoxia during the first 2 h after birth by means of blood analyses of hypoxanthine, lactate, base deficit, and pH was investigated in six infants with a 1 min Apgar score of less than or equal to 4."3.66Hypoxanthine as a test of perinatal hypoxia as compared to lactate, base deficit, and pH. ( Bratteby, LE; Swanström, S, 1982)
" Alterations in coronary flow were induced by hypoxia, amobarbital (Amytal) infusion, increase in work load of the heart, and adenosine infusion."3.66Role of mitochondrial oxidative phosphorylation in regulation of coronary blood flow. ( Erecińska, M; Nishiki, K; Nuutinen, EM; Wilson, DF, 1982)
" A diagnosis of idiopathic lactic acidosis was established when the arterial blood pH was found to be 6."3.64THE CLINICAL SIGNIFICANCE OF ELEVATED BLOOD LACTATE. ( PHILLIPSON, EA; SPROULE, BJ, 1965)
" Future studies should focus on potential dose-response effects and the involved mechanisms."3.30Repeated Short-Term Bouts of Hyperoxia Improve Aerobic Performance in Acute Hypoxia. ( Dünnwald, T; Faulhaber, M; Gatterer, H; Kennedy, MD; Menz, V; Rausch, LK; Schneider, S; Schobersberger, W, 2023)
"Currently, hypothermia is the only approved clinical treatment available for HIE."3.01Exogenous lactate administration: A potential novel therapeutic approach for neonatal hypoxia-ischemia. ( Deng, Q; Duan, R; Liu, TC; Wu, C; Yang, L, 2023)
"Lactate acidosis is often observed in the tumor microenvironment (TME) of solid tumors."3.01Lactate acidosis and simultaneous recruitment of TGF-β leads to alter plasticity of hypoxic cancer cells in tumor microenvironment. ( Arora, MK; Banerjee, S; Kaithwas, G; Mishra, SS; Rastogi, S; Ravichandiran, V; Roy, S; Singh, L, 2023)
"Hypoxemia is readily detectable by assessing SpO2 levels, and these are important in optimizing COVID-19 patient management."3.01Longitudinal Monitoring of Lactate in Hospitalized and Ambulatory COVID-19 Patients. ( Gabor, J; Kieu Linh, LT; Kreidenweiss, A; Kremsner, PG; Krishna, S; Velavan, TP, 2021)
"Compared to normoxemia, hypoxemia did not significantly modify the resting concentrations of TBARS and RAA, and did not affect the consumption of ascorbic acid after 60% MVC but suppressed the post-exercise TBARS increase."2.70Acute hypoxemia does not increase the oxidative stress in resting and contracting muscle in humans. ( Dousset, E; Faucher, M; Jammes, Y; Steinberg, JG, 2002)
"Glycogenolysis was lower with DCA, resulting in reduced lactate concentration ([lactate]), despite similar phosphorylase a mole fractions and posttransformational regulators."2.69Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia. ( Heigenhauser, GJ; Hollidge-Horvat, MG; Hultman, E; Jones, NL; Matsos, MP; Parolin, ML; Spriet, LL, 2000)
"1."2.68The effect of altitude hypoxia on glucose homeostasis in men. ( Dela, F; Galbo, H; Hansen, JM; Larsen, JJ; Olsen, NV, 1997)
"Global metabolism of cancers exhibits a peculiar phenotype that is lactate acidosis (high lactate with acidic pH) in tumor microenvironment."2.61Lactate as a signaling molecule: Journey from dead end product of glycolysis to tumor survival. ( Chhonker, SK; Koiri, RK; Mehrotra, A; Naik, RA; Rawat, D; Trigun, SK, 2019)
"Early-onset hyperlactatemia is that which develops in the operating room or very early following intensive care unit (ICU) admission."2.55Hyperlactatemia and Cardiac Surgery. ( Minton, J; Sidebotham, DA, 2017)
"Although interest in lactate for cancer development only appeared recently, pharmacological molecules blocking its metabolism are already in phase I/II clinical trials."2.53Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters. ( Marchiq, I; Pouysségur, J, 2016)
"Inflammation is an important component of normal responses to infection and injury."2.49Metabolomics--a novel window into inflammatory disease. ( Fitzpatrick, M; Young, SP, 2013)
"Before heating, locally advanced cervical cancers are mostly hypoxic, acidic, exhibit substrate and energy deprivation and show lactate accumulation, which is spatially and temporally heterogeneous."2.48Blood flow and associated pathophysiology of uterine cervix cancers: characterisation and relevance for localised hyperthermia. ( Kelleher, DK; Vaupel, PW, 2012)
"DC have been shown to infiltrate many tumors but both, circulating and tumor-infiltrating DC from cancer patients, appear to be phenotypically and functionally defective."2.44Tumor-induced modulation of dendritic cell function. ( Gottfried, E; Kreutz, M; Mackensen, A, 2008)
"During prolonged anoxia at low temperature, freshwater turtles develop high plasma concentrations of both lactate and calcium."2.42Surviving extreme lactic acidosis: the role of calcium lactate formation in the anoxic turtle. ( Jackson, DC, 2004)
"This is also true for patients in septic shock after plasma volume expansion."2.39[Is infection and septic shock caused by a global oxygen deficiency? An overview in 2 parts. 1: Infection and correlation between DO2 and VO2]. ( Ensinger, H; Georgieff, M, 1996)
"Under high-altitude hypoxia environment, the body is more prone to fatigue, which occurs in both peripheral muscles and the central nervous system (CNS)."1.91Monocarboxylate transporter-dependent mechanism is involved in the adaptability of the body to exercise-induced fatigue under high-altitude hypoxia environment. ( Gao, C; Li, Y; Pei, W; Yang, B, 2023)
"This study demonstrates that acute high altitude hypoxia upregulated the lactic acid/amino acid-pyruvate-TCA pathways and fatty acid oxidation, but downregulated glycolysis in the liver of mice."1.91Energy metabolic mechanisms for high altitude sickness: Downregulation of glycolysis and upregulation of the lactic acid/amino acid-pyruvate-TCA pathways and fatty acid oxidation. ( Jiang, C; Li, Y; Liao, N; Liu, G; Shang, X; Shao, D; Shi, J; Xu, F; Yin, D, 2023)
"Solid tumors have developed robust ferroptosis resistance."1.91HIF-1α drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1. ( Guan, Q; Qin, C; Qu, S; Su, W; Wang, Y; Wei, X; Xiang, J; Yang, Z; Yao, B; Zen, K; Zhao, D; Zhou, J, 2023)
" In our study, patients were administered a daily dosage of 2 × 600 mg of diosmin for 3 months, and we evaluated several factors associated with oxygen management, angiogenesis, and inflammation using biochemical assays."1.91Effect of Diosmin on Selected Parameters of Oxygen Homeostasis. ( Dresler, S; Feldo, M; Płachno, BJ; Samborski, D; Sowa, I; Sowa, P; Wójciak, M, 2023)
"During intervertebral disc degeneration (IVDD), due to endplate calcification, diminished oxygen and nutrient concentrations and accumulated lactate are present in the microenvironment of the nucleus pulposus (NP)."1.72Monocarboxylate transporter 1-mediated lactate accumulation promotes nucleus pulposus degeneration under hypoxia in a 3D multilayered nucleus pulposus degeneration model. ( Bit, A; Hsieh, MK; Hu, YJ; Lai, PL; Wang, CY, 2022)
"Hypoxia is a common concern in shrimp aquaculture, affecting growth and survival."1.72Changes in metabolic profiling of whiteleg shrimp (Penaeus vannamei) under hypoxic stress. ( Alfaro, AC; Bayot, B; Nguyen, TV; Rodríguez, J; Sonnenholzner, S, 2022)
"Gestational hypoxemia is often associated with reduced birth weight, yet how hypoxemia controls uteroplacental nutrient metabolism and supply to the fetus is unclear."1.62Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia. ( Brown, LD; Jones, AK; Julian, CG; Limesand, SW; Lorca, RA; Moore, LG; Rozance, PJ; Wesolowski, SR, 2021)
"NIP2;1 expression is limited to the "anoxia core" region of the root stele under normal growth conditions, but shows substantial induction (up to 1,000-fold by 2-4 h of hypoxia) by low oxygen stress, and accumulation in all root tissues."1.62Aquaporin family lactic acid channel NIP2;1 promotes plant survival under low oxygen stress in Arabidopsis. ( Beamer, ZG; Choi, WG; Lokdarshi, A; Roberts, DM; Routray, P; Spangler, MK, 2021)
"Melanoma is the most lethal of all skin-related cancers with incidences continuously rising."1.62In Vitro Evaluation of CD276-CAR NK-92 Functionality, Migration and Invasion Potential in the Presence of Immune Inhibitory Factors of the Tumor Microenvironment. ( Baden, C; Chan, KC; Grote, S; Handgretinger, R; Mezger, M; Schleicher, S; Ureña-Bailén, G, 2021)
"Hypoxia and inflammation are hallmarks of critical illness, related to multiple organ failure."1.62Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males. ( Bergmans, DCJJ; Driessen, RGH; Gerretsen, J; Kiers, D; Kox, M; Pickkers, P; Schalkwijk, CG; Scheijen, JLJM; van Bussel, BCT; van de Poll, MCG; van der Horst, ICC, 2021)
"Hypovolemia was induced and maintained for 20 min by removal of 50% of the total blood volume; thereafter, the animals were retransfused."1.56Altered Cerebral Blood Flow and Potential Neuroprotective Effect of Human Relaxin-2 (Serelaxin) During Hypoxia or Severe Hypovolemia in a Sheep Model. ( Bischoff, SJ; Irintchev, A; Lehmann, T; Lemke, C; Nistor, M; Schiffner, R; Schmidt, M, 2020)
"In solid tumors, hypoxia can trigger aberrant expression of transcription factors and genes, resulting in abnormal biological functions such as altered energetic pathways in cancer cells."1.56Computational modeling to determine key regulators of hypoxia effects on the lactate production in the glycolysis pathway. ( Hashemzadeh, S; Omidi, Y; Rafii-Tabar, H; Shahmorad, S, 2020)
"IDH1 mutant gliomas have distinct metabolic and microenvironment characteristics compared with wild type gliomas."1.51Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI. ( Chakhoyan, A; Cloughesy, TF; Ellingson, BM; Everson, RG; Lai, A; Liau, LM; Mareninov, S; Nathanson, DA; Nghiemphu, PL; Pope, WB; Prins, RM; Raymond, C; Salamon, N; Yao, J; Yong, WH, 2019)
"Ischemia was followed by a significant increase in muscle myeloperoxidase activity, as well as interleukin-6 and thiobarbituric acid reactive substances species levels."1.48N-acetylcysteine effects on a murine model of chronic critical limb ischemia. ( Constantino, L; da Silva, LA; Dal-Pizzol, F; Dall'Igna, DM; de Medeiros, WA; Dos Santos Cardoso, J; Manfredini, A; Michels, M; Ritter, C; Scaini, G; Streck, EL; Vuolo, F, 2018)
"Cholesteatoma has attracted many studies seeking to uncover its nature and the pathogenesis of related diseases."1.48Comparison of changes in mitochondrial bioenergetics between keratinocytes in human external auditory canal skin and cholesteatomas from normoxia to hypoxia. ( Chen, HC; Chen, HK; Chen, YT; Kuo, CY; Lee, JT; Lin, YC; Lin, YY; Shih, CP; Wang, CH, 2018)
"We suspect that exercise-induced hypoxemia occurring during running could be at the origin of the RBC rheological behavior differences with cycling."1.48Eryptosis and hemorheological responses to maximal exercise in athletes: Comparison between running and cycling. ( Connes, P; Fort, R; Germain, M; Guillot, N; Hancco, I; Joly, P; Lavorel, L; Nader, E; Renoux, C; Stauffer, E, 2018)
"Hypoxemia is one of the most common pathological processes in various clinical diseases."1.48High-performance reoxygenation from PLGA-PEG/PFOB emulsions: a feedback relationship between ROS and HIF-1α. ( He, D; Huang, G; Li, N; Shen, X; Wang, J; Wang, R; Zhu, J, 2018)
"Unearthing embryology-like processes in tumors may allow us to control organ-like tumor features such as tissue repair and revascularization and treat intratumoral heterogeneity."1.46Metabolic origins of spatial organization in the tumor microenvironment. ( Akkari, L; Carmona-Fontaine, C; Deforet, M; Joyce, JA; Thompson, CB; Xavier, JB, 2017)
"Recent research suggest that anoxia-tolerant fish transfer extracellular nitrite into the tissues, where it is used for nitric oxide (NO) generation, iron-nitrosylation, and S-nitrosation of proteins, as part of the cytoprotective response toward prolonged hypoxia and subsequent reoxygenation."1.43Nitric oxide availability in deeply hypoxic crucian carp: acute and chronic changes and utilization of ambient nitrite reservoirs. ( Gerber, L; Hansen, MN; Jensen, FB, 2016)
"After 1 week of anoxia, a major part of the glycogen stores was mobilized in liver (79."1.43Glycogen dynamics of crucian carp (Carassius carassius) in prolonged anoxia. ( Haverinen, J; Vornanen, M, 2016)
"Exercise-induced arterial hypoxemia (EIAH) is often found in endurance-trained subjects at high exercise intensity."1.42Exercise effects on erythrocyte deformability in exercise-induced arterial hypoxemia. ( Alis, R; Blesa, JR; Ferioli, D; La Torre, A; Romagnoli, M; Sanchis-Gomar, F, 2015)
"With intermittent anoxia, the pattern of substrate effects on the NAP changed markedly so that low concentrations of fructose became able to support neurophysiologic activity but not high concentrations of glucose."1.42Anoxia-induced changes in optimal substrate for peripheral nerve. ( Stecker, MM; Stevenson, MR, 2015)
"BxPC-3 pancreatic cancer cells were cultured under hypoxic conditions and treated with or without the nanoparticles."1.42PLGA/poloxamer nanoparticles loaded with EPAS1 siRNA for the treatment of pancreatic cancer in vitro and in vivo. ( Fang, W; Li, K; Li, L; Pan, X; Sun, Y; Zhao, Z; Zhu, Q; Zhu, Y; Zuo, J, 2015)
"High uric acid (UA) has been found to be correlated with renal dysfunction in some experimental and clinical studies; however, the study of the dynamic correlation between AKI and UA in severe burns is still lacking."1.42Elevated serum uric acid after injury correlates with the early acute kidney in severe burns. ( Hu, X; Liang, J; Zhang, P; Zhi, L, 2015)
"Acute mountain sickness is caused by sub-acute hypoxia in healthy individuals going rapidly to altitude."1.39The antioxidative effect of a novel free radical scavenger 4'-hydroxyl-2-substituted phenylnitronyl nitroxide in acute high-altitude hypoxia mice. ( Fan, PC; Jia, ZP; Jing, LL; Li, L; Ma, HP, 2013)
"While respiratory alkalosis occurred in patients with better preservation of FEV1, respiratory acidosis was observed with more severe airway obstruction, as was increased lactate in the majority of patients, independent of PaO(2) and PaCO(2) levels."1.39Acid-base patterns in acute severe asthma. ( Adrogué, HJ; Gonzalez, S; Menga, G; Raimondi, GA; Zaltsman, J, 2013)
"We have shown earlier that breast cancer cells secrete higher levels of interleukin-6 (IL-6) under hypoxia, leading to the recruitment of hMSCs towards hypoxic tumor cells."1.38Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment. ( Ackerstaff, E; Banerjee, D; Glod, JW; Koutcher, JA; Patel, BB; Rattigan, YI; Sukenick, G, 2012)
"Only 65% of patients with septic shock had hyperlactataemia at the onset of shock and 76% of these also had a high lactate/pyruvate ratio."1.38Lactate/pyruvate ratio as a marker of tissue hypoxia in circulatory and septic shock. ( Bruzzi de Carvahlo, F; Cotton, F; De Backer, D; Orellano-Jimenez, C; Rimachi, R; Vincent, JL, 2012)
"However, EPAOC after 36 h of anoxia could not account for RMR being maintained."1.37Anoxic survival of the Pacific hagfish (Eptatretus stoutii). ( Cox, GK; Farrell, AP; Richards, JG; Sandblom, E, 2011)
"Histamine was released during hypoxia and reoxygenation and also reperfusion, as was tryptase β, and high concentrations of adenosine (>1 µmol litre⁻¹, hypoxia group) and inosine (> 7 µmol litre⁻¹, ischaemia group) were measured in effluent (P < 0."1.37Shedding of the coronary endothelial glycocalyx: effects of hypoxia/reoxygenation vs ischaemia/reperfusion. ( Annecke, T; Becker, BF; Conzen, P; Fischer, J; Hartmann, H; Rehm, M; Sommerhoff, CP; Tschoep, J, 2011)
"Chuvash polycythemia (CP) is an autosomal recessive human disorder in which the regulatory degradation of HIF is impaired, resulting in elevated levels of HIF at normal oxygen tensions."1.36Regulation of human metabolism by hypoxia-inducible factor. ( Cheeseman, J; Clarke, K; Constantin-Teodosiu, D; Dorrington, KL; Edwards, LM; Emmanuel, Y; Formenti, F; Frayn, KN; Greenhaff, PL; Humphreys, SM; Karpe, F; Lappin, TR; McMullin, MF; McNamara, CJ; Mills, W; Murphy, JA; O'Connor, DF; Percy, MJ; Ratcliffe, PJ; Robbins, PA; Smith, TG; Treacy, M, 2010)
"Insulin sensitivity was assessed using the euglycemic clamp before and after the exposures."1.35Effects of acute intermittent hypercapnic hypoxia on insulin sensitivity in piglets using euglycemic clamp. ( Aouad, LJ; Tam, K; Waters, KA, 2008)
"Nutritional interventions for intrauterine growth restriction (IUGR) have raised concerns for fetal toxicity, the mechanisms of which are unknown."1.35Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction. ( Barry, JS; Brown, LD; Hay, WW; Limesand, SW; Rozance, PJ, 2009)
"SRBD patients had obstructive sleep apnea syndrome with or without sleep-related hypoventilation/hypoxemic conditions."1.35Nocturnal hypoxia and arterial lactate levels in sleep-related breathing disorders. ( Erbaycu, AE; Guclu, SZ; Kirakli, C; Taymaz, Z; Tuksavul, F; Ucar, ZZ, 2009)
"During septic shock, muscle produces lactate by way of an exaggerated NaK-adenosine triphosphatase (ATPase)-stimulated aerobic glycolysis associated with epinephrine stimulation possibly through beta2 adrenoreceptor involvement."1.35Increased aerobic glycolysis through beta2 stimulation is a common mechanism involved in lactate formation during shock states. ( Desebbe, O; Gibot, S; Levy, B; Montemont, C, 2008)
"Moreover, the stimulatory effect of anoxia on glycolytic flux was inversely correlated to the relative reliance on aerobic glycolysis."1.35Aerobic glycolysis in cancers: implications for the usability of oxygen-responsive genes and fluorodeoxyglucose-PET as markers of tissue hypoxia. ( Busk, M; Bussink, J; Horsman, MR; Kristjansen, PE; Overgaard, J; van der Kogel, AJ, 2008)
"For each measurement, the more anoxia-tolerant species (painted turtle, Chrysemys picta; snapping turtle, Chelydra serpentina) had higher values than the less anoxia-tolerant species (musk turtle, Sternotherus odoratus; map turtle, Graptemys geographica; red-eared slider, Trachemys scripta)."1.34Comparative shell buffering properties correlate with anoxia tolerance in freshwater turtles. ( Asare, VS; Gall, JM; Jackson, DC; Reese, SA; Taylor, SE; Villarnovo, D, 2007)
"Muscle lactate formation in endotoxic shock was further inhibited by intravenous infusion of ICI-118551 or dichloroacetate (DCA), an activator of pyruvate dehydrogenase (DCA) and their combination."1.34Myocardial lactate deprivation is associated with decreased cardiovascular performance, decreased myocardial energetics, and early death in endotoxic shock. ( Gibot, S; Lacolley, P; Lecompte, T; Levy, B; Mallie, JP; Mansart, A; Montemont, C; Regnault, V, 2007)
"Muscles utilize glycogen during anoxia more at warmer temperatures."1.34Effects of temperature on anoxic submergence: skeletal buffering, lactate distribution, and glycogen utilization in the turtle, Trachemys scripta. ( Jackson, DC; Warren, DE, 2007)
"We assessed the anoxia tolerance of A."1.34Extreme anoxia tolerance in embryos of the annual killifish Austrofundulus limnaeus: insights from a metabolomics analysis. ( Fan, TW; Higashi, R; Lopez, JP; Podrabsky, JE; Somero, GN, 2007)
" The fatigue task altered the dose-response relationship to intramuscular acidic saline injections."1.34Muscle fatigue increases the probability of developing hyperalgesia in mice. ( Lisi, TL; Moore, SA; Sluka, KA; Yokoyama, T, 2007)
"After a stabilization period, prolonged hypoxemia (FiO(2): 0."1.33Excitatory amino acid release and electrocortical brain activity after hypoxemia in near-term lambs. ( Hopman, J; Ruitenbeek, W; van de Bor, M; van Os, S, 2006)
"Neonatal anoxia was induced by placing 2-day-old rat pups into a glass chamber with 100% N(2) atmosphere, T=36."1.33Selected biochemical variables in a model of neonatal anoxia in rats. ( Dubovický, M; Mach, M; Navarová, J; Schmidtová, M; Ujházy, E, 2006)
"Hemorrhagic shock was induced in 48 anesthetized rats by withdrawing 28 mL/kg blood."1.33Fluid resuscitation with hemoglobin-vesicle solution does not increase hypoxia or inflammatory responses in moderate hemorrhagic shock. ( Goto, Y; Horinouchi, H; Miyashita, M; Sakai, H; Sakamoto, A; Terajima, K; Tsuchida, E; Tsueshita, T, 2006)
"Our data also suggest that chronic hypoxemia depresses mechanosensitive muscle afferents."1.32Comparison between the effects of chronic and acute hypoxemia on muscle afferent activities from the tibialis anterior muscle. ( Decherchi, P; Dousset, E; Grelot, L; Jammes, Y, 2003)
"Acute hypoxemia was subsequently induced in all fetuses by reducing maternal fractional inspired oxygen concentration for 1 h."1.32Hindlimb glucose and lactate metabolism during umbilical cord compression and acute hypoxemia in the late-gestation ovine fetus. ( Fowden, AL; Gardner, DS; Giussani, DA, 2003)
"Postmortem hypoxemia was induced by cervical dislocation."1.32The contribution of glycolytic and oxidative pathways to retinal photoreceptor function. ( Bui, BV; Kalloniatis, M; Vingrys, AJ, 2003)
"Compared with a control group, COPD patients had lower MVCs, an attenuated decrease in MF during exercise, lower resting level of GSH, no posthandgrip TBARS increase and no GSH consumption."1.32Influence of chronic hypoxemia on peripheral muscle function and oxidative stress in humans. ( Barbier, D; Faucher, M; Hug, F; Jammes, Y; Steinberg, JG, 2004)
"Adenosine is a product of adenylate phosphate breakdown that can exert protective effects on tissues during energy limitation."1.32Cardiorespiratory and tissue adenosine responses to hypoxia and reoxygenation in the short-horned sculpin Myoxocephalus scorpius. ( Driedzic, WR; Maccormack, TJ, 2004)
"After 60 min of anoxia, stage 27HH hearts did not retrieve their baseline activity."1.31Developmental changes in cardiac recovery from anoxia-reoxygenation. ( Kucera, P; Raddatz, E; Sedmera, D, 2002)
"During hypoxemia, both the pretreatment with endotoxin and nicotine induced higher levels of extracellular lactate and peak lactate/pyruvate ratio compared with controls (54."1.31Detrimental effects of nicotine and endotoxin in the newborn piglet brain during severe hypoxemia. ( Amerio, G; Frøen, JF; Saugstad, OD; Stray-Pedersen, B, 2002)
"In painted turtles anoxia induced a significant increase in myocardial HSP72/73 (from 2."1.31Expression of heat shock proteins in turtle and mammal hearts: relationship to anoxia tolerance. ( Chang, J; Knowlton, AA; Wasser, JS, 2000)
"With hypoxemia, time had a significant effect on V(O2) and body temperature in an age-dependent fashion: that is, whereas the 1 week group and the 4-5 week group showed both variables decreasing over time, the 2-3 week group showed no drop in V(O2) and a small increase in body temperature over time."1.31Age-dependent metabolic effects of repeated hypoxemia in piglets. ( Barter, J; Côté, A; Meehan, B, 2000)
"Shell and bone ¿Na(+) both fell during anoxia but the fate of this Na(+) is uncertain because plasma ¿Na(+) also fell."1.31Bone and shell contribution to lactic acid buffering of submerged turtles Chrysemys picta bellii at 3 degrees C. ( Crocker, CE; Jackson, DC; Ultsch, GR, 2000)
"cylindriformis, survives anoxia for only 2 days at 25 degrees C."1.31Anoxia tolerance of con-familial tiger beetle larvae is associated with differences in energy flow and anaerobiosis. ( Hand, SC; Higley, LG; Hoback, WW; Podrabsky, JE; Stanley, DW, 2000)
"Severe hypoxemia induces similar alterations of renal excretion in newborn piglets."1.31Effect of severe normocapnic hypoxia on renal function in growth-restricted newborn piglets. ( Bauer, R; Walter, B; Zwiener, U, 2000)
"Although arterial hypoxemia developed during the second run, arterial PO2 values were significantly (P < 0."1.31Effect of prior high-intensity exercise on exercise-induced arterial hypoxemia in Thoroughbred horses. ( Goetz, TE; Hassan, AS; Manohar, M, 2001)
"Furthermore, at 15 degrees C anoxia reduced the ATP turnover rate to 50% of the normoxic rate."1.30Energy turnover in the normoxic and anoxic turtle heart. ( Arthur, PG; Cousins, KL; Farrell, AP; Franklin, CE; Hochachka, PW; Thorarensen, H, 1997)
"Progressive graded hypoxemia was induced by decreasing fractional inspiratory oxygen concentration (FIO2) from 1."1.30Mixed venous oxygen saturation and biochemical parameters of hypoxia during progressive hypoxemia in 10- to 14-day-old piglets. ( Blanco, CE; Maertzdorf, WJ; van der Hoeven, MA, 1997)
"Many enzyme activities in Alzheimer's disease (AD) are changed."1.30Affected enzyme activities in Alzheimer's disease are sensitive to antemortem hypoxia. ( Bothmer, J; Jolles, J; Meng, F; Terwel, D; Wolf, E, 1998)
"Lactic acid production was also significantly suppressed in the subzero nonfreezing group compared with that in the control group."1.30Subzero nonfreezing storage of isolated rat hepatocytes in University of Wisconsin solution. ( Matsuda, H; Matsuoka, J; Tanaka, N; Yagi, T; Yamamura, H, 1999)
"When hearts could adjust their HR, hypoxemia demanded more energy than ischemia (p < 0."1.29Effects of energy demand in ischemic and in hypoxemic isolated rat hearts. ( Allibardi, S; Casalini, S; Corno, A; Samaja, M, 1994)
"Hindlimb O2 transport decreased with hypoxemia, but O2 consumption remained unchanged in both groups."1.29Hydroxymalonate inhibits lactate uptake by the rabbit hindlimb. ( Arbelaez, G; Chakravarthy, S; Fernandez, E; Gutierrez, G; Hurtado, FJ; Kiiski, R; Ronco, JJ, 1994)
"To evaluate the effect of hypoxemia on cardiac release of neuropeptide Y-like immunoreactivity (NPY-LI) and norepinephrine (NE), arterial and coronary sinus blood was sampled and coronary sinus blood flow was measured by thermodilution in nine healthy volunteers at rest and during supine cycle ergometer exercise while they breathed air and 12% O2, which reduced arterial O2 saturation to approximately 68%."1.29Neuropeptide Y release from human heart is enhanced during prolonged exercise in hypoxia. ( Berglund, B; Grubbström, J; Kaijser, L; Lundberg, JM; Pernow, J, 1994)
"Glycogen depletion by anoxia or glucagon before ischemia impaired recovery."1.29Metabolic recovery of isolated working rat heart after brief global ischemia. ( Goodwin, GW; Taegtmeyer, H, 1994)
"Ipsilateral testicular torsion causes a decrease not only in the ipsilateral torted but also in the contralateral nontorted testicular perfusion."1.29Ipsilateral and contralateral testicular biochemical acute changes after unilateral testicular torsion and detorsion. ( Akgür, FM; Büyükpamukçu, N; Hiçsönmez, A; Kilinç, K; Tanyel, FC, 1994)
"Maternal hypoxemia resulted in no change in fetal mixed arterio-venous pH (7."1.29Cerebral energy metabolism in fetal guinea pigs during moderate maternal hypoxemia at 0.75 of gestation. ( Berger, R; Jensen, A; Krieglstein, J; Steigelmann, JP, 1993)
"Induced hypoxemia resulted in a variable degree of fetal acidemia that was entirely metabolic."1.29Cerebral metabolism during sustained hypoxemia in preterm fetal sheep. ( Asano, H; Carmichael, L; Homan, J; Korkola, S; Richardson, B, 1994)
"Induced fetal hypoxemia resulted in a lactic metabolic acidosis that progressively worsened, with death occurring in three of the animals during the early recovery period."1.29Recovery of the ovine fetus from sustained hypoxia: effects on endocrine, cardiovascular, and biophysical activity. ( Carmichael, L; Fraher, L; Matsuda, Y; Patrick, J; Richardson, B, 1994)
"During anoxia we measured a four- to sixfold increase of the interstitial lactate concentration."1.29Interstitial lactate and glucose concentrations of the isolated perfused rat heart before, during and after anoxia. ( Kammermeier, H; Strupp, M, 1993)
"The present study used a model of cardiac tamponade to investigate the effects of endotoxin on the oxygen extraction capabilities of the body during an acute reduction in blood flow, when blood volume and arterial oxygen content were maintained."1.29Oxygen extraction is altered by endotoxin during tamponade-induced stagnant hypoxia in the dog. ( Vincent, JL; Zhang, H, 1993)
"During anoxia all 14C remained in the animal indicating no urine production."1.29Lactate distribution and metabolism during and after anoxia in the turtle, Chrysemys picta bellii. ( Jackson, DC; Okamoto, S; Toney, VI, 1996)
"After 45 min of anoxia, total lactate production was less in immature tubules (101 +/- 48 micrograms of lactate/mg of DNA) compared with mature tubules (148 +/- 36 micrograms of lactate/mg of DNA)."1.29Glycolysis is not responsible for the tolerance of immature renal tubules to anoxia. ( Gaudio, KM; Siegel, NJ; Thulin, G, 1996)
"Exposure to 30 h anoxia resulted in significant increases in the activities of skeletal muscle and heart catalase (by 53 and 47%), heart and brain glutathione peroxidase (by 75 and 30%), and brain glutathione S-transferase (by 66%)."1.29Relationship between anoxia exposure and antioxidant status in the frog Rana pipiens. ( Hermes-Lima, M; Storey, KB, 1996)
"During hypoxemia, pressure dropped initially, as observed during ischemia."1.29Dynamics of myocardial adaptation to low-flow ischemia and hypoxemia. ( Allibardi, S; de Jong, JW; Merati, G; Monti, LD; Samaja, M, 1996)
"Induced fetal hypoxemia resulted in a progressive lactic metabolic acidosis; however, all fetuses had recovered within 24 hours."1.28Effects of sustained hypoxemia on the sheep fetus at midgestation: endocrine, cardiovascular, and biophysical responses. ( Carmichael, L; Challis, J; Matsuda, Y; Patrick, J; Richardson, B, 1992)
"Lactate formation at the onset of anoxia is proportional to stimulus frequency."1.28ATP formation and energy demand in anoxic heart muscle of the rabbit. ( Dietrich, DL; Elzinga, G, 1992)
"To test the hypothesis that long-term hypoxemia affects fetal cardiac function, we measured right (RVO) and left (LVO) ventricular output by electromagnetic flow probes."1.28Right and left ventricular function in fetal sheep exposed to long-term high-altitude hypoxemia. ( Gilbert, RD; Kamitomo, M; Longo, LD, 1992)
"In contrast to the hepatoma cells, rat and human hepatocytes exhibited higher rates of anaerobic glycolysis in the presence of fructose and thus were able to maintain their viability under these conditions."1.28Differences in glycolytic capacity and hypoxia tolerance between hepatoma cells and hepatocytes. ( Anundi, I; de Groot, H; Hugo-Wissemann, D; Lauchart, W; Viebahn, R, 1991)
"During CO2 acidosis, anoxia had no effect on apparent nonbicarbonate buffer value (d[HCO3-]/dpHi = 71 and 89 mM/pH in normoxia and anoxia, respectively) or on pHi regulation (dpHi/dpHe = 0."1.2831P-NMR study of normoxic and anoxic perfused turtle heart during graded CO2 and lactic acidosis. ( Arendt, EA; Inman, KC; Jackson, DC; Lawler, RG; Panol, G; Wasser, JS, 1991)
"Arterial hypoxemia decreased epicardial tissue PO2, measured by means of a multiwire surface electrode, as well as coronary venous PO2 and myocardial lactate extraction."1.28Epicardial oxygen tensions during changes in arterial PO2 in pigs. ( Baier, H; Brendel, W; Christ, M; Conzen, PF; Goetz, A; Habazettl, H; Peter, K; Vollmar, B, 1990)
"During anoxia, hyperglycemic cats showed higher brain lactate levels (26 versus 20 mumol/g), but similar ATP and phosphocreatine concentrations, compared with normoglycemic cats."1.28Delayed neurologic deterioration following anoxia: brain mitochondrial and metabolic correlates. ( Kleinholz, M; Myers, RE; Wagner, KR, 1989)
"Ischemia and anoxia were induced in the area perfused by the distal left anterior descending artery in 32 mongrel dogs."1.27Different effects of acute ischemia and anoxia on the canine myocardium. ( Hattori, S; Mori, H; Nagata, M; Nakamura, Y; Sakurai, K; Takahashi, M, 1984)
"During lung anoxia produced by ventilation with CO, glucose utilization and lactate production were again markedly decreased by addition of lactate (2 mM) to the perfusate."1.27Lactate and regulation of lung glycolytic rate. ( Dodia, C; Fisher, AB, 1984)
"The periods of hypoxemia and ischemia lasted 56."1.27Bioenergetics of rabbit skeletal muscle during hypoxemia and ischemia. ( Andry, JM; Gutierrez, G; Narayana, P; Pohil, RJ; Strong, R, 1988)
"The effects of prolonged mild hypoxemia on the fetus have received little attention."1.27The effect of mild hypoxemia maintained for twenty-four hours on maternal and fetal glucose, lactate, cortisol, and arginine vasopressin in pregnant sheep at 122 to 139 days' gestation. ( Elias, B; Figueroa, J; Markowitz, S; Nathanielsz, P; Towell, ME, 1987)
"When the hypoxemia-induced reduction in O2 consumption was less than 15% of the baseline value (at fractional concentration of inspired oxygen 0."1.27Oxygen transport and metabolism in the conscious lamb: the effects of hypoxemia. ( Lister, G; Moreau, G; Moss, M, 1987)
"To examine the effects of hypoxemia on carbohydrate and O2 consumption by the fetal kidney, we inserted catheters into the descending aorta, inferior vena cava, and left renal vein of 14 fetal sheep at 120-130 days gestation."1.27Metabolic responses of the kidney in fetal sheep: effect of acute and spontaneous hypoxemia. ( Iwamoto, HS; Rudolph, AM, 1985)
"After 15 min of hypoxemia we repeated the measurements."1.26Fetal myocardial oxygen and carbohydrate consumption during acutely induced hypoxemia. ( Fisher, DJ; Heymann, MA; Rudolph, AM, 1982)
"Total lactate rose during anoxia to a mean peak value of 145 mM, but the decrease in HCO-3 and Cl- and increase in K+ balanced less than 40% of the lactate."1.26Plasma ion balance of submerged anoxic turtles at 3 degrees C: the role of calcium lactate formation. ( Heisler, N; Jackson, DC, 1982)
"The effect of temperature, either along or in combination with pentobarbital or phenytoin, on survival time in the hypoxic (Flo2 = 0."1.26Influence of hypothermia or hyperthermia alone or in combination with pentobarbital or phenytoin on survival time in hypoxic mice. ( Artru, AA; Michenfelder, JD, 1981)
"We conclude that with progressive hypoxemia, CMRO2 remains stable until oxygen demand exceeds oxygen delivery, resulting thereafter in a progressive reduction in CMRO2."1.26Canine cerebral metabolism and blood flow during hypoxemia and normoxic recovery from hypoxemia. ( Artru, AA; Michenfelder, JD, 1981)

Research

Studies (912)

TimeframeStudies, this research(%)All Research%
pre-1990142 (15.57)18.7374
1990's206 (22.59)18.2507
2000's254 (27.85)29.6817
2010's218 (23.90)24.3611
2020's92 (10.09)2.80

Authors

AuthorsStudies
Jones, AK1
Rozance, PJ2
Brown, LD2
Lorca, RA1
Julian, CG1
Moore, LG1
Limesand, SW3
Wesolowski, SR1
Flores-Sauceda, M1
Camacho-Jiménez, L1
Peregrino-Uriarte, AB1
Leyva-Carrillo, L1
Arvizu-Flores, A1
Yepiz-Plascencia, G1
Dennis, MC1
Goods, PSR1
Binnie, MJ1
Girard, O4
Wallman, KE1
Dawson, B3
Billaut, F2
Peeling, P3
Yamagata, K2
Zúñiga, A1
Camacho, M1
Chang, HJ1
Fristot, E1
Mayonove, P1
Hani, EH1
Bonnet, J1
Beamer, ZG1
Routray, P1
Choi, WG2
Spangler, MK1
Lokdarshi, A1
Roberts, DM2
Huynh, KW1
Pamenter, ME1
Wang, CY1
Hsieh, MK1
Hu, YJ1
Bit, A1
Lai, PL1
Sumartiningsih, S1
Rahayu, S1
Handoyo, E1
Lin, JC1
Lim, CL1
Starczewski, M1
Fuchs, PX1
Kuo, CH2
Wang, Z1
Li, H1
Wang, H3
Li, X4
Zhang, Q3
Li, K2
Qiu, Y1
Baryła, I1
Styczeń-Binkowska, E1
Płuciennik, E1
Kośla, K1
Bednarek, AK1
Sinenchenko, A1
Lodyagin, A1
Loladze, A1
Batotsyrenov, B1
Antonova, A1
Kovalenko, A1
Jena, BC1
Das, CK1
Banerjee, I1
Bharadwaj, D1
Majumder, R1
Das, S1
Biswas, A1
Kundu, M1
Roy, PK1
Kundu, CN1
Mandal, M1
Morris, NL1
Michael, DN1
Crotty, KM1
Chang, SS1
Yeligar, SM1
Daboss, EV1
Tikhonov, DV1
Shcherbacheva, EV1
Karyakin, AA1
Pouysségur, J2
Marchiq, I2
Parks, SK1
Durivault, J1
Ždralević, M1
Vucetic, M1
Öğünç Keçeci, Y1
İncesu, Z1
Nguyen, TV1
Alfaro, AC1
Rodríguez, J1
Bayot, B1
Sonnenholzner, S1
Liu, S2
Zhao, H1
Hu, Y3
Yan, C1
Mi, Y1
Tao, D1
Qin, J1
Kennedy, L1
Glesaaen, ER1
Palibrk, V1
Pannone, M1
Wang, W2
Al-Jabri, A1
Suganthan, R1
Meyer, N2
Austbø, ML1
Lin, X2
Bergersen, LH2
Bjørås, M1
Rinholm, JE1
Xu, Z1
Dai, X1
Chen, L2
Cheng, Z1
Lin, H1
Zhou, Z1
Guo, Z1
Yang, Y4
Li, L7
Zhao, Q2
Li, Y5
Liu, Z1
Hao, L1
Guo, B1
Diao, A1
Afzal, J3
Suhail, Y3
Chang, H3
Hubbi, ME3
Hamidzadeh, A3
Goyal, R3
Liu, Y8
Sun, P3
Nicoli, S3
Dang, CV3
Levchenko, A3
Sun, L2
Gao, W3
Liu, J4
Wang, J7
Yu, H2
Xu, ZP2
Goldberg, FW2
Kettle, JG2
Lamont, GM2
Buttar, D2
Ting, AKT2
McGuire, TM2
Cook, CR2
Beattie, D2
Morentin Gutierrez, P2
Kavanagh, SL2
Komen, JC2
Kawatkar, A2
Clark, R2
Hopcroft, L2
Hughes, G2
Critchlow, SE2
Ruan, S1
Yin, W1
Chang, J2
Sun, J1
Ma, X1
Zang, J1
Ren, T1
Dong, H1
Raberin, A1
Willis, SJ2
Richard, T1
Elmer, J1
Vernillo, G1
Iaia, FM1
Malatesta, D1
Millet, GP4
Yang, L3
Gilbertsen, A1
Xia, H1
Benyumov, A1
Smith, K1
Herrera, J1
Racila, E1
Bitterman, PB1
Henke, CA1
Fan, M1
Yang, K1
Wang, X5
Gill, PS1
Ha, T1
Liu, L1
Lewis, NH1
Williams, DL1
Li, C2
Gao, C2
Yang, B2
Pei, W2
Jiang, T1
Liang, YS1
Gu, Y1
Yao, FC1
Liu, YF2
Zhang, KX1
Song, FB1
Sun, JL2
Luo, J2
Todorova, V1
Stauffacher, MF1
Ravotto, L1
Nötzli, S1
Karademir, D1
Ebner, LJA1
Imsand, C1
Merolla, L1
Hauck, SM1
Samardzija, M1
Saab, AS1
Barros, LF1
Weber, B1
Grimm, C1
Shi, ZB1
Ruan, QQ1
Geng, YN1
Cheng, X1
Zhao, M1
Zhu, LL1
Deng, Q1
Wu, C1
Liu, TC1
Duan, R1
Liu, G2
Liao, N1
Shang, X1
Xu, F1
Yin, D1
Shao, D1
Jiang, C2
Shi, J1
Yan, K1
He, Q1
Lin, D1
Liang, J2
Chen, J2
Xie, Z1
Chen, Z1
Yang, Z2
Su, W1
Wei, X1
Qu, S1
Zhao, D1
Zhou, J1
Wang, Y5
Guan, Q1
Qin, C1
Xiang, J1
Zen, K1
Yao, B1
Filippi, L1
Pascarella, F1
Pini, A1
Cammalleri, M1
Bagnoli, P1
Morganti, R1
Innocenti, F1
Castagnini, N1
Melosi, A1
Scaramuzzo, RT1
Rastogi, S1
Mishra, SS1
Arora, MK1
Kaithwas, G1
Banerjee, S1
Ravichandiran, V1
Roy, S1
Singh, L1
Centner, FS1
Schoettler, JJ1
Brohm, K1
Mindt, S1
Jäger, E1
Hahn, B1
Fuderer, T1
Lindner, HA1
Schneider-Lindner, V1
Krebs, J1
Neumaier, M1
Thiel, M1
Feldo, M1
Wójciak, M1
Dresler, S1
Sowa, P1
Płachno, BJ1
Samborski, D1
Sowa, I1
Paganini, M1
Moon, RE1
Giacon, TA1
Cialoni, D1
Martani, L1
Zucchi, L1
Garetto, G1
Talamonti, E1
Camporesi, EM1
Bosco, G1
Nho, RS1
Rice, C1
Prasad, J1
Bone, H1
Farkas, L1
Rojas, M1
Horowitz, JC1
Faulhaber, M8
Schneider, S1
Rausch, LK1
Dünnwald, T3
Menz, V4
Gatterer, H8
Kennedy, MD1
Schobersberger, W1
Yan, W1
Lv, Q1
Miao, Y1
Wei, Z1
Tian, Q1
Li, J2
Wu, B2
Xiao, Q1
Tian, N1
Yi, L1
Luo, M1
Li, Z2
Pang, Y2
Shi, X1
Dong, Z1
Gnocchi, D1
Nikolic, D1
Castellaneta, F1
Paparella, RR1
Sabbà, C1
Mazzocca, A1
Chattopadhyay, A1
Jagdish, S1
Karhale, AK1
Ramteke, NS1
Zaib, A1
Nandi, D1
Malila, Y1
Thanatsang, K1
Arayamethakorn, S1
Uengwetwanit, T1
Srimarut, Y1
Petracci, M1
Strasburg, GM1
Rungrassamee, W1
Visessanguan, W1
Lindberg, CD1
Di Giulio, RT1
Zhang, D1
Tang, Z1
Huang, H2
Zhou, G1
Cui, C2
Weng, Y1
Liu, W1
Kim, S1
Lee, S1
Perez-Neut, M1
Ding, J1
Czyz, D1
Hu, R1
Ye, Z1
He, M1
Zheng, YG1
Shuman, HA1
Dai, L1
Ren, B1
Roeder, RG1
Becker, L1
Zhao, Y1
Fornasiero, A1
Skafidas, S1
Stella, F1
Zignoli, A1
Savoldelli, A2
Rakobowchuk, M1
Pellegrini, B1
Schena, F1
Mourot, L1
Czuba, M2
Bril, G1
Płoszczyca, K1
Piotrowicz, Z1
Chalimoniuk, M1
Roczniok, R1
Zembroń-Łacny, A1
Gerasimuk, D1
Langfort, J1
Zhao, LL1
Wu, H2
Liao, L1
Liu, Q1
Tang, XH1
Luo, W1
Ma, JD1
Ye, X1
Li, SJ1
Yang, S1
Kamel, KS2
Oh, MS1
Halperin, ML2
Kulesza, A1
Leonard, EM1
McClelland, GB3
Ivashkiv, LB1
Surmeli Onay, O1
Korkmaz, A1
Yigit, S1
Yurdakok, M1
Gándara, L1
Durrieu, L1
Behrensen, C1
Wappner, P1
Drzazga, Z1
Schisler, I1
Poprzęcki, S1
Michnik, A1
Sha, AL1
Hao, HY1
Vanspranghels, R1
De Jonckheere, J1
Drumez, E1
Lauriot Dit Prevost, A1
Sharma, D1
Ghesquiere, L1
Storme, L1
Houfflin-Debarge, V1
Garabedian, C1
Wang, L1
Zhu, R1
Yu, S1
Zhang, Y3
Schiffner, R1
Bischoff, SJ1
Lehmann, T1
Irintchev, A1
Nistor, M1
Lemke, C1
Schmidt, M1
Mira, J1
Floreani, M1
Amery, K1
Koral, J1
Oranchuk, DJ1
Messonnier, LA1
Rupp, T1
Millet, GY1
Stephens, EH1
Epting, CL1
Backer, CL1
Wald, EL1
Kucuk, A1
Cumhur Cure, M1
Cure, E1
Hashemzadeh, S1
Shahmorad, S1
Rafii-Tabar, H1
Omidi, Y1
Mikrogeorgiou, A1
Chen, Y1
Lee, BS1
Bok, R1
Sheldon, RA1
Barkovich, AJ1
Xu, D1
Ferriero, DM1
Walden, TP1
Jonson, AM1
Dempsey, AR1
Marston, KJ1
Scott, BR4
Tang, J1
Meka, AK1
Theivendran, S1
Song, H1
Fu, J1
Ban, W1
Gu, Z1
Lei, C1
Li, S1
Yu, C2
Tassinari, ID1
Andrade, MKG1
da Rosa, LA1
Hoff, MLM1
Nunes, RR1
Vogt, EL1
Fabres, RB1
Sanches, EF1
Netto, CA1
Paz, AH1
de Fraga, LS1
Griffiths, A1
Deighton, K1
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Clinical Trials (21)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Study on the Diagnostic Value of Multi-omics Combined Detection for Precancerous Lesions of Colorectal Cancer[NCT05530746]500 participants (Anticipated)Observational2022-05-01Recruiting
An Open-label, Multi-center, Phase 1b Study to Investigate the Safety and Tolerability of SLC-0111 (WBI-5111) in Combination With Gemcitabine in Metastatic Pancreatic Ductal Adenocarcinoma Subjects Positive for Carbonic Anhydrase IX[NCT03450018]Phase 1/Phase 230 participants (Anticipated)Interventional2019-01-10Recruiting
An Observational Cohort Study to Validate SEARCH, a Novel Hierarchical Algorithm to Define Long-term Outcomes After Pulmonary Embolism[NCT05568927]150 participants (Anticipated)Observational2022-11-01Enrolling by invitation
Mean Arterial Pressure (MAP) Trial: Study Protocol for a Multicenter, Randomized, Controlled Trial to Compare Three Different Strategies of Mean Arterial Pressure Management During Cardiopulmonary By-pass[NCT05740397]900 participants (Anticipated)Interventional2021-05-03Recruiting
Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)[NCT05120284]Phase 240 participants (Anticipated)Interventional2022-07-01Recruiting
Renal Effects of Erythropoietin in Humans[NCT01584921]Phase 116 participants (Actual)Interventional2012-03-31Completed
Effects of Endogenous Iron Status and Intravenous Iron on Human Skeletal Muscle Metabolism at Rest and During Exercise[NCT02308449]29 participants (Actual)Interventional2014-10-31Completed
Using the ΔvapCO2 / Cav02 Ratio as a Prognostic Marker and Predictor of Complications After Cardiac Surgery[NCT02876406]150 participants (Anticipated)Observational [Patient Registry]2016-10-31Recruiting
Peripheral Perfusion Versus Lactate Targeted Fluid Resuscitation in Septic Shock: ANDROMEDA-SHOCK PHYSIOLOGY STUDY[NCT03762005]46 participants (Anticipated)Interventional2018-06-01Recruiting
Brain During Effort : Effects of Hypoxia With Respiratory Patients[NCT02854280]33 participants (Actual)Interventional2013-06-30Completed
Agreement Between Arterial, Central Venous, and Peripheral Venous Lactate in the Intensive Care Unit[NCT01624519]50 participants (Anticipated)Interventional2012-08-31Not yet recruiting
Remote Ischemic Conditioning as a Treatment for Traumatic Brain Injury: a Prospective Randomized Controlled Trial.[NCT03176823]40 participants (Anticipated)Interventional2019-05-03Recruiting
Markers of Tissue Perfusion as Predictors of Complicated Evolution in Patients With Left Ventricular Dysfunction Submitted to Coronary Artery Bypass Surgery[NCT01178866]87 participants (Actual)Observational2006-01-31Completed
Effect of Exercise-induced Hypoxemia on Cytokine and Stress Hormone Responses Among Endurance-trained Athletes[NCT04305873]50 participants (Anticipated)Observational2020-03-01Enrolling by invitation
Resuscitation Failure, Protein Carbonyl and Receptor Interacting Protein Kinase 3 as Mortality Predictor in Septic Patient[NCT04169412]72 participants (Actual)Observational [Patient Registry]2019-02-22Completed
"Influence of High Vitamin C Dose on Lactate During Extracorporeal Circulation for Heart Surgery and During the 24 Hours Thereafter. (Double Blind Prospective Randomised Study)"[NCT04046861]200 participants (Anticipated)Interventional2023-02-01Not yet recruiting
Effectiveness of Chest Compressions Under Mild Hypoxia: Should Rescuers Breathe Supplemental Oxygen on Commercial Flights?[NCT04072484]19 participants (Actual)Interventional2019-08-16Terminated (stopped due to Research at the University of Chicago was halted in March 2020.)
Cardiovascular and Metabolic Physiological Adaptations to Intermittent Hypoxia. Physiological Aspects and Expression of Receptors and Cellular Mediators[NCT02058823]Phase 412 participants (Actual)Interventional2013-08-07Terminated (stopped due to budget constraints)
The Insulin Sensitivity Using Aerobic Interval Conditioning[NCT01286922]42 participants (Actual)Interventional2009-07-31Completed
Near-infrared Spectroscopic Measurement of Tissue Oxygen Saturation and the Vascular Occlusion Test in Complex Regional Pain Syndrome[NCT01586377]20 participants (Actual)Observational2011-08-31Completed
Long-term Oxygen Therapy in Patients With Chronic Obstructive Pulmonary Disease (COPD) Who Live at High Altitude (2640 Meters Above Sea Level): Evaluation of a Proposal for Adjusting Criteria[NCT03020212]220 participants (Anticipated)Interventional2016-02-29Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

55 reviews available for lactic acid and Anoxemia

ArticleYear
Lactate Supply from Astrocytes to Neurons and its Role in Ischemic Stroke-induced Neurodegeneration.
    Neuroscience, 2022, 01-15, Volume: 481

    Topics: Animals; Astrocytes; Hypoxia; Ischemic Stroke; Lactic Acid; Neurons

2022
'Warburg effect' controls tumor growth, bacterial, viral infections and immunity - Genetic deconstruction and therapeutic perspectives.
    Seminars in cancer biology, 2022, Volume: 86, Issue:Pt 2

    Topics: Animals; Bacteria; Cell Line, Tumor; Humans; Hypoxia; Lactic Acid; Monocarboxylic Acid Transporters;

2022
Exogenous lactate administration: A potential novel therapeutic approach for neonatal hypoxia-ischemia.
    Experimental neurology, 2023, Volume: 367

    Topics: Humans; Hypothermia; Hypothermia, Induced; Hypoxia; Hypoxia-Ischemia, Brain; Infant, Newborn; Ischem

2023
Lactate acidosis and simultaneous recruitment of TGF-β leads to alter plasticity of hypoxic cancer cells in tumor microenvironment.
    Pharmacology & therapeutics, 2023, Volume: 250

    Topics: Acidosis; Humans; Hypoxia; Lactic Acid; Neoplasms; Transforming Growth Factor beta; Tumor Microenvir

2023
L-lactic acidosis: pathophysiology, classification, and causes; emphasis on biochemical and metabolic basis.
    Kidney international, 2020, Volume: 97, Issue:1

    Topics: Acidosis, Lactic; Anions; Bicarbonates; Citric Acid Cycle; Critical Illness; Electron Transport Chai

2020
Hyperlactatemia: An Update on Postoperative Lactate.
    World journal for pediatric & congenital heart surgery, 2020, Volume: 11, Issue:3

    Topics: Acidosis, Lactic; Biomarkers; Cardiac Surgical Procedures; Female; Humans; Hyperlactatemia; Hypoxia;

2020
Astrocytic nutritional dysfunction associated with hypoxia-induced neuronal vulnerability in stroke-prone spontaneously hypertensive rats.
    Neurochemistry international, 2020, Volume: 138

    Topics: Animals; Astrocytes; Cell Death; Cells, Cultured; Humans; Hypertension; Hypoxia; Lactic Acid; Neuron

2020
Practical Management of ECPELLA.
    International heart journal, 2020, Nov-28, Volume: 61, Issue:6

    Topics: Acidosis; Assisted Circulation; Combined Modality Therapy; Extracorporeal Membrane Oxygenation; Femo

2020
Quantitative Assessment of Blood Lactate in Shock: Measure of Hypoxia or Beneficial Energy Source.
    BioMed research international, 2020, Volume: 2020

    Topics: Animals; Critical Illness; Disease Models, Animal; Dogs; Humans; Hypoxia; Lactic Acid; Liver; Models

2020
Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance.
    Cells, 2020, 12-04, Volume: 9, Issue:12

    Topics: Amino Acids; Animals; Citric Acid Cycle; Dimerization; Disease Progression; Drug Resistance, Neoplas

2020
The role of lactate in sepsis and COVID-19: Perspective from contracting skeletal muscle metabolism.
    Experimental physiology, 2022, Volume: 107, Issue:7

    Topics: Adrenergic Agents; COVID-19; Humans; Hypoxia; Lactate Dehydrogenases; Lactic Acid; Muscle, Skeletal;

2022
Exercise during short-term exposure to hypoxia or hyperoxia - novel treatment strategies for type 2 diabetic patients?!
    Scandinavian journal of medicine & science in sports, 2018, Volume: 28, Issue:2

    Topics: Diabetes Mellitus, Type 2; Exercise Therapy; Glucose; Humans; Hyperoxia; Hypoxia; Insulin Resistance

2018
Lactate metabolism: historical context, prior misinterpretations, and current understanding.
    European journal of applied physiology, 2018, Volume: 118, Issue:4

    Topics: Astrocytes; Energy Metabolism; Exercise; Humans; Hypoxia; Lactic Acid; Neurons

2018
Lactate as a signaling molecule: Journey from dead end product of glycolysis to tumor survival.
    Frontiers in bioscience (Landmark edition), 2019, 01-01, Volume: 24, Issue:2

    Topics: Cell Hypoxia; Cell Line, Tumor; Cell Survival; Glycolysis; Humans; Hydrogen-Ion Concentration; Hypox

2019
The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression.
    International journal of radiation biology, 2019, Volume: 95, Issue:7

    Topics: Adenosine Triphosphate; Animals; Biomass; Cell Line, Tumor; Cell Proliferation; Cellular Reprogrammi

2019
Hypoxia, lactate accumulation, and acidosis: siblings or accomplices driving tumor progression and resistance to therapy?
    Advances in experimental medicine and biology, 2013, Volume: 789

    Topics: Acidosis; Disease Progression; Drug Resistance, Neoplasm; Humans; Hypoxia; Lactic Acid; Neoplasms

2013
Lactate or ScvO2 as an endpoint in resuscitation of shock states?
    Minerva anestesiologica, 2013, Volume: 79, Issue:9

    Topics: Endpoint Determination; Humans; Hypoxia; Lactic Acid; Oxygen; Prognosis; Resuscitation; Shock; Shock

2013
Lactate and the injured brain: friend or foe?
    Current opinion in critical care, 2014, Volume: 20, Issue:2

    Topics: Brain Injuries; Cerebral Cortex; Cerebrovascular Circulation; Energy Metabolism; Female; Glycolysis;

2014
Analysis of hypoxia-induced metabolic reprogramming.
    Methods in enzymology, 2014, Volume: 542

    Topics: Autophagy; Carbon Isotopes; Cell Culture Techniques; Culture Media; Glucose; Glycolysis; Humans; Hyd

2014
Metabolic aspects of high-altitude adaptation in Tibetans.
    Experimental physiology, 2015, Volume: 100, Issue:11

    Topics: Adaptation, Physiological; Altitude; Basic Helix-Loop-Helix Transcription Factors; Energy Metabolism

2015
Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters.
    Journal of molecular medicine (Berlin, Germany), 2016, Volume: 94, Issue:2

    Topics: Animals; Antineoplastic Agents; Basigin; Biomarkers; Energy Metabolism; Humans; Hypoxia; Lactic Acid

2016
Performance Enhancement: What Are the Physiological Limits?
    Physiology (Bethesda, Md.), 2015, Volume: 30, Issue:4

    Topics: Acclimatization; Adaptation, Physiological; Altitude; Anaerobic Threshold; Exercise; Humans; Hypoxia

2015
The Kenyan runners.
    Scandinavian journal of medicine & science in sports, 2015, Volume: 25 Suppl 4

    Topics: Ammonia; Arteries; Athletic Performance; Humans; Hypoxia; Kenya; Lactic Acid; Lung; Muscle, Skeletal

2015
Cerebral Lactate Metabolism After Traumatic Brain Injury.
    Current neurology and neuroscience reports, 2016, Volume: 16, Issue:4

    Topics: Animals; Brain Injuries; Cerebrovascular Circulation; Glucose; Humans; Hypoxia; Lactic Acid; Neuropr

2016
Hyperlactatemia and Cardiac Surgery.
    The journal of extra-corporeal technology, 2017, Volume: 49, Issue:1

    Topics: Acidosis, Lactic; Biomarkers; Cardiac Surgical Procedures; Humans; Hyperlactatemia; Hypoxia; Lactic

2017
The anti-oxidant capacity of tumour glycolysis.
    International journal of radiation biology, 2009, Volume: 85, Issue:11

    Topics: Animals; Antioxidants; DNA Damage; Glycolysis; Humans; Hypoxia; Lactic Acid; Luminescent Measurement

2009
Hypoxia-inducible factors and their roles in energy metabolism.
    International journal of hematology, 2012, Volume: 95, Issue:5

    Topics: Animals; Carbohydrate Metabolism; Energy Metabolism; Humans; Hypoxia; Hypoxia-Inducible Factor 1; La

2012
Blood flow and associated pathophysiology of uterine cervix cancers: characterisation and relevance for localised hyperthermia.
    International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2012, Volume: 28, Issue:6

    Topics: Animals; Cervix Uteri; Female; Glucose; Humans; Hyperthermia, Induced; Hypoxia; Lactic Acid; Uterine

2012
Endothelial cell metabolism and tumour angiogenesis: glucose and glutamine as essential fuels and lactate as the driving force.
    Journal of internal medicine, 2013, Volume: 273, Issue:2

    Topics: Angiogenesis Inhibitors; Endothelial Cells; Endothelium, Vascular; Glucose; Glutamine; Glycolysis; H

2013
Metabolomics--a novel window into inflammatory disease.
    Swiss medical weekly, 2013, Volume: 143

    Topics: Animals; Biomarkers; Energy Metabolism; Humans; Hypoxia; Inflammation; Lactic Acid; Metabolomics; Me

2013
Cellular pathophysiology. Part 2: Responses following hypoxia.
    Professional nurse (London, England), 2003, Volume: 18, Issue:11

    Topics: Blood Volume; Calcium; Cell Membrane; Cell Physiological Phenomena; Energy Metabolism; Free Radicals

2003
Performing at extreme altitude: muscle cellular and subcellular adaptations.
    European journal of applied physiology, 2003, Volume: 90, Issue:3-4

    Topics: Acclimatization; Adult; Altitude; Atmospheric Pressure; Body Weight; Citrate (si)-Synthase; Electron

2003
Acid-base balance at exercise in normoxia and in chronic hypoxia. Revisiting the "lactate paradox".
    European journal of applied physiology, 2003, Volume: 90, Issue:5-6

    Topics: Acid-Base Equilibrium; Adenosine Triphosphate; Energy Metabolism; Exercise; Glycolysis; Homeostasis;

2003
Limiting factors to oxygen transport on Mount Everest 30 years after: a critique of Paolo Cerretelli's contribution to the study of altitude physiology.
    European journal of applied physiology, 2003, Volume: 90, Issue:3-4

    Topics: Acclimatization; Altitude; Arteries; Atmospheric Pressure; Capillaries; Cardiac Output; Cardiovascul

2003
Arterial desaturation during exercise in man: implication for O2 uptake and work capacity.
    Scandinavian journal of medicine & science in sports, 2003, Volume: 13, Issue:6

    Topics: Adolescent; Adult; Aged; Animals; Blood Gas Analysis; Cardiovascular Physiological Phenomena; Child;

2003
Acid-base balance during hypoxic hypometabolism: selected vertebrate strategies.
    Respiratory physiology & neurobiology, 2004, Aug-12, Volume: 141, Issue:3

    Topics: Acclimatization; Acid-Base Equilibrium; Animals; Carbon Dioxide; Environment; Fishes; Hydrogen-Ion C

2004
Surviving extreme lactic acidosis: the role of calcium lactate formation in the anoxic turtle.
    Respiratory physiology & neurobiology, 2004, Dec-15, Volume: 144, Issue:2-3

    Topics: Acidosis, Lactic; Adaptation, Physiological; Animals; Bone and Bones; Calcium; Calcium Compounds; Hu

2004
Bench-to-bedside review: oxygen debt and its metabolic correlates as quantifiers of the severity of hemorrhagic and post-traumatic shock.
    Critical care (London, England), 2005, Oct-05, Volume: 9, Issue:5

    Topics: Acid-Base Equilibrium; Acidosis; Animals; Disease Models, Animal; Dogs; Humans; Hypovolemia; Hypoxia

2005
Lactate as a marker of energy failure in critically ill patients: hypothesis.
    Critical care (London, England), 2005, Volume: 9, Issue:6

    Topics: Acid-Base Equilibrium; Biomarkers; Critical Care; Critical Illness; Disease Progression; Energy Meta

2005
Lactate and shock state: the metabolic view.
    Current opinion in critical care, 2006, Volume: 12, Issue:4

    Topics: Humans; Hypoxia; Lactic Acid; Shock

2006
Lactate and shock state: the metabolic view.
    Current opinion in critical care, 2006, Volume: 12, Issue:4

    Topics: Humans; Hypoxia; Lactic Acid; Shock

2006
Lactate and shock state: the metabolic view.
    Current opinion in critical care, 2006, Volume: 12, Issue:4

    Topics: Humans; Hypoxia; Lactic Acid; Shock

2006
Lactate and shock state: the metabolic view.
    Current opinion in critical care, 2006, Volume: 12, Issue:4

    Topics: Humans; Hypoxia; Lactic Acid; Shock

2006
Fundamentals of oxygen delivery.
    Contributions to nephrology, 2007, Volume: 156

    Topics: Biological Transport; Energy Metabolism; Humans; Hypoxia; Lactic Acid; Lung; Mitochondria; Oxygen

2007
Lactate metabolism in anoxic turtles: an integrative review.
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2008, Volume: 178, Issue:2

    Topics: Adaptation, Physiological; Animals; Hypoxia; Lactic Acid; Turtles

2008
Tumor-induced modulation of dendritic cell function.
    Cytokine & growth factor reviews, 2008, Volume: 19, Issue:1

    Topics: Animals; Cell Differentiation; Cyclooxygenase 2; Dendritic Cells; Dinoprostone; Humans; Hypoxia; Lac

2008
A reexamination of the role of oxygen in retrolental fibroplasia.
    Pediatrics, 1984, Volume: 73, Issue:1

    Topics: Anencephaly; Apnea; Carbon Dioxide; Cerebral Hemorrhage; Ductus Arteriosus, Patent; Exchange Transfu

1984
Potassium loss during myocardial ischaemia and hypoxia: does lactate efflux play a role?
    Cardiovascular research, 1994, Volume: 28, Issue:8

    Topics: Biological Transport; Cell Membrane; Humans; Hypoxia; Lactates; Lactic Acid; Myocardial Ischemia; My

1994
[Is infection and septic shock caused by a global oxygen deficiency? An overview in 2 parts. 1: Infection and correlation between DO2 and VO2].
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 1996, Volume: 31, Issue:3

    Topics: Acid-Base Equilibrium; Cardiac Output; Humans; Hypoxia; Lactates; Lactic Acid; Oxygen; Oxygen Consum

1996
Lactate during exercise at high altitude.
    European journal of applied physiology and occupational physiology, 1996, Volume: 74, Issue:3

    Topics: Acclimatization; Altitude; Biological Transport, Active; Glycogen; Glycolysis; Humans; Hypoxia; Lact

1996
Is the maximal accumulated oxygen deficit an adequate measure of the anaerobic capacity?
    Canadian journal of applied physiology = Revue canadienne de physiologie appliquee, 1996, Volume: 21, Issue:5

    Topics: Anaerobic Threshold; Anaerobiosis; Exercise; Humans; Hypoxia; Lactic Acid; Muscle, Skeletal; Oxygen

1996
Brain anaerobic lactate production: a suicide note or a survival kit?
    Developmental neuroscience, 1998, Volume: 20, Issue:4-5

    Topics: Anaerobiosis; Animals; Brain; Brain Ischemia; Energy Metabolism; Hypoxia; Lactic Acid

1998
[Clinical evaluation and methodological aspects of serum lactate].
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 1999, Volume: 34, Issue:4

    Topics: Biomarkers; Humans; Hypoxia; Lactic Acid

1999
Lactate is an unreliable indicator of tissue hypoxia in injury or sepsis.
    Lancet (London, England), 1999, Aug-07, Volume: 354, Issue:9177

    Topics: Cell Hypoxia; Humans; Hypoxia; Lactic Acid; Resuscitation; Sensitivity and Specificity; Systemic Inf

1999
Lung injury and lactate production: a hypoxic stimulus?
    Critical care medicine, 1999, Volume: 27, Issue:11

    Topics: Biomarkers; Humans; Hypoxia; Lactic Acid; Lung; Respiratory Distress Syndrome

1999
Anaerobic performance at altitude.
    International journal of sports medicine, 1992, Volume: 13 Suppl 1

    Topics: Acclimatization; Altitude; Energy Metabolism; Exercise; Humans; Hypoxia; Lactates; Lactic Acid; Musc

1992
Contact lens-induced corneal endothelial polymegathism: functional significance and possible mechanisms.
    American journal of optometry and physiological optics, 1986, Volume: 63, Issue:7

    Topics: Actin Cytoskeleton; Biomechanical Phenomena; Calcium; Carbon Dioxide; Contact Lenses; Cornea; Cornea

1986
Inflammation, glycolytic metabolism, and glycosaminoglycans.
    Experimental pathology, 1986, Volume: 30, Issue:1

    Topics: Aerobiosis; Animals; Cell Division; Cells, Cultured; Glycolysis; Glycosaminoglycans; Hypoxia; Inflam

1986

Trials

80 trials available for lactic acid and Anoxemia

ArticleYear
Systemic Lactate Elevation Induced by Tobacco Smoking during Rest and Exercise Is Not Associated with Nicotine.
    International journal of environmental research and public health, 2022, 03-02, Volume: 19, Issue:5

    Topics: Adult; Carbon; Cross-Over Studies; Electronic Nicotine Delivery Systems; Humans; Hypoxia; Lactic Aci

2022
Repeated Short-Term Bouts of Hyperoxia Improve Aerobic Performance in Acute Hypoxia.
    Journal of strength and conditioning research, 2023, Oct-01, Volume: 37, Issue:10

    Topics: Bicycling; Female; Humans; Hyperoxia; Hypoxia; Lactic Acid; Male; Oxygen

2023
Sessional work-rate does not affect the magnitude to which simulated hypoxia can augment acute physiological responses during resistance exercise.
    European journal of applied physiology, 2020, Volume: 120, Issue:10

    Topics: Exercise Tolerance; Heart Rate; Humans; Hypoxia; Lactic Acid; Male; Muscle, Skeletal; Oxygen Consump

2020
Longitudinal Monitoring of Lactate in Hospitalized and Ambulatory COVID-19 Patients.
    The American journal of tropical medicine and hygiene, 2021, Jan-11, Volume: 104, Issue:3

    Topics: Adolescent; Adult; Ambulatory Care Facilities; Biomarkers; Comorbidity; COVID-19; Female; Germany; H

2021
Four weeks of high-intensity training in moderate, but not mild hypoxia improves performance and running economy more than normoxic training in horses.
    Physiological reports, 2021, Volume: 9, Issue:4

    Topics: Animals; Biomarkers; Cardiorespiratory Fitness; Cross-Over Studies; Exercise Test; Exercise Toleranc

2021
Blueberry supplementation reduces the blood lactate response to running in normobaric hypoxia but has no effect on performance in recreational runners.
    Journal of the International Society of Sports Nutrition, 2021, Mar-30, Volume: 18, Issue:1

    Topics: Adult; Anthocyanins; Athletic Performance; Biomarkers; Blueberry Plants; Cross-Over Studies; Dietary

2021
Normobaric hypoxia increases the growth hormone response to maximal resistance exercise in trained men.
    European journal of sport science, 2017, Volume: 17, Issue:7

    Topics: Adult; Cross-Over Studies; Electromyography; Exercise; Heart Rate; Human Growth Hormone; Humans; Hyp

2017
Changes in acid-base and ion balance during exercise in normoxia and normobaric hypoxia.
    European journal of applied physiology, 2017, Volume: 117, Issue:11

    Topics: Acid-Base Equilibrium; Adult; Exercise; Humans; Hypoxia; Lactic Acid; Male; Oxygen

2017
Acute effects of repeated cycling sprints in hypoxia induced by voluntary hypoventilation.
    European journal of applied physiology, 2017, Volume: 117, Issue:12

    Topics: Adult; Bicycling; Hemoglobins; Humans; Hypoventilation; Hypoxia; Lactic Acid; Male; Myoglobin; Oxyge

2017
Effect of high-intensity resistance circuit-based training in hypoxia on aerobic performance and repeat sprint ability.
    Scandinavian journal of medicine & science in sports, 2018, Volume: 28, Issue:10

    Topics: Adult; Athletic Performance; Basal Metabolism; Energy Metabolism; Hemoglobins; High-Intensity Interv

2018
Acute Effects of Interset Rest Duration on Physiological and Perceptual Responses to Resistance Exercise in Hypoxia.
    Journal of strength and conditioning research, 2020, Volume: 34, Issue:8

    Topics: Adult; Cross-Over Studies; Electromyography; Heart Rate; Humans; Hypoxia; Lactic Acid; Male; Myalgia

2020
Bench press performance during an intermittent hypoxic resistance training to muscle failure.
    The Journal of sports medicine and physical fitness, 2019, Volume: 59, Issue:7

    Topics: Adult; Cross-Over Studies; Humans; Hypoxia; Lactic Acid; Male; Muscle Fatigue; Myalgia; Resistance T

2019
Partial Range of Motion Exercise Is Effective for Facilitating Muscle Hypertrophy and Function Through Sustained Intramuscular Hypoxia in Young Trained Men.
    Journal of strength and conditioning research, 2019, Volume: 33, Issue:5

    Topics: Arm; Electromyography; Humans; Hypertrophy; Hypoxia; Lactic Acid; Male; Muscle Strength; Muscle Stre

2019
Effects of oxytocin and carbetocin on farrowing performance.
    Animal reproduction science, 2019, Volume: 205

    Topics: Animals; Animals, Newborn; Female; Fetal Blood; Hypoxia; Lactic Acid; Oxytocics; Oxytocin; Parturiti

2019
Ischemic Preconditioning Maintains Performance on Two 5-km Time Trials in Hypoxia.
    Medicine and science in sports and exercise, 2019, Volume: 51, Issue:11

    Topics: Adult; Bicycling; Cross-Over Studies; Heart Rate; Humans; Hypoxia; Ischemic Preconditioning; Lactic

2019
[Individual systemic reactions of human organism under acute hypoxia].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2012, Volume: 98, Issue:11

    Topics: Adult; Blood Flow Velocity; Blood Glucose; Brain; Brain Waves; Cerebrovascular Circulation; Energy M

2012
Effect of different simulated altitudes on repeat-sprint performance in team-sport athletes.
    International journal of sports physiology and performance, 2014, Volume: 9, Issue:5

    Topics: Acid-Base Equilibrium; Altitude; Athletic Performance; Biomarkers; Competitive Behavior; Group Proce

2014
Effects of resistance training under hypoxic conditions on muscle hypertrophy and strength.
    Clinical physiology and functional imaging, 2015, Volume: 35, Issue:3

    Topics: Biomarkers; Healthy Volunteers; Human Growth Hormone; Humans; Hypertrophy; Hypoxia; Lactic Acid; Mal

2015
Effects of acute exposure to mild simulated hypoxia on hormonal responses to low-intensity resistance exercise in untrained men.
    Research in sports medicine (Print), 2014, Volume: 22, Issue:3

    Topics: Adult; Biomarkers; Cross-Over Studies; Exercise; Healthy Volunteers; Human Growth Hormone; Humans; H

2014
Impact of exercise and moderate hypoxia on glycemic regulation and substrate oxidation pattern.
    PloS one, 2014, Volume: 9, Issue:10

    Topics: Adult; Blood Glucose; Exercise; Fatty Acids, Nonesterified; Glycerol; Heart Rate; Humans; Hypoxia; I

2014
Effect of Intermittent Hypoxic Training Followed by Intermittent Hypoxic Exposure on Aerobic Capacity of Long Distance Runners.
    Journal of strength and conditioning research, 2016, Volume: 30, Issue:6

    Topics: Adaptation, Physiological; Adult; Exercise Test; Exercise Tolerance; Female; Heart Rate; Humans; Hyp

2016
Effect of repeat-sprint training in hypoxia on post-exercise interleukin-6 and F2-isoprostanes.
    European journal of sport science, 2016, Volume: 16, Issue:8

    Topics: Adult; Altitude; F2-Isoprostanes; Heart Rate; Humans; Hypoxia; Inflammation; Interleukin-6; Lactic A

2016
Seven Passive 1-h Hypoxia Exposures Do Not Prevent AMS in Susceptible Individuals.
    Medicine and science in sports and exercise, 2016, Volume: 48, Issue:12

    Topics: Acclimatization; Adult; Altitude Sickness; Blood Gas Analysis; Double-Blind Method; Female; Heart Ra

2016
Short-Term Hypoxic Exposure and Training Improve Maximal Anaerobic Running Test Performance.
    Journal of strength and conditioning research, 2018, Volume: 32, Issue:1

    Topics: Female; Humans; Hypoxia; Lactic Acid; Oxygen Consumption; Physical Endurance; Running; Young Adult

2018
Biochemical responses and physical performance during high-intensity resistance circuit training in hypoxia and normoxia.
    European journal of applied physiology, 2017, Volume: 117, Issue:4

    Topics: Adult; Anaerobic Threshold; Bicarbonates; Exercise Tolerance; High-Intensity Interval Training; Huma

2017
Physiological Factors Associated With Declining Repeated Sprint Performance in Hypoxia.
    Journal of strength and conditioning research, 2019, Volume: 33, Issue:1

    Topics: Acceleration; Adult; Athletes; Athletic Performance; Cross-Over Studies; Exercise Test; Heart Rate;

2019
High-intensity kayak performance after adaptation to intermittent hypoxia.
    International journal of sports physiology and performance, 2006, Volume: 1, Issue:3

    Topics: Adaptation, Physiological; Adolescent; Adult; Athletic Performance; Biomarkers; Cross-Over Studies;

2006
Altitude hypoxia increases glucose uptake in human heart.
    High altitude medicine & biology, 2009,Spring, Volume: 10, Issue:1

    Topics: Adult; Altitude; Fluorodeoxyglucose F18; Glucose; Heart; Humans; Hypoxia; Lactic Acid; Male; Myocard

2009
Cycling performance following adaptation to two protocols of acutely intermittent hypoxia.
    International journal of sports physiology and performance, 2009, Volume: 4, Issue:1

    Topics: Adaptation, Physiological; Adult; Bicycling; Confidence Intervals; Exercise Test; Heart Rate; Humans

2009
The role of ribose on oxidative stress during hypoxic exercise: a pilot study.
    Journal of medicinal food, 2009, Volume: 12, Issue:3

    Topics: Antioxidants; Bicycling; Cross-Over Studies; Dietary Carbohydrates; Dietary Supplements; Double-Blin

2009
Acute altitude-induced hypoxia suppresses plasma glucose and leptin in healthy humans.
    Metabolism: clinical and experimental, 2010, Volume: 59, Issue:2

    Topics: Adult; Altitude; Blood Glucose; C-Peptide; Epinephrine; Female; Glucose; Humans; Hypoxia; Insulin; I

2010
Substrate utilization during exercise and recovery at moderate altitude.
    Metabolism: clinical and experimental, 2010, Volume: 59, Issue:7

    Topics: Adult; Altitude; Anaerobic Threshold; Blood Glucose; Carbon Dioxide; Cardiovascular Physiological Ph

2010
Training in normobaric hypoxia and its effects on acute mountain sickness after rapid ascent to 4559 m.
    High altitude medicine & biology, 2010,Spring, Volume: 11, Issue:1

    Topics: Acclimatization; Adult; Altitude Sickness; Blood Gas Analysis; Double-Blind Method; Female; Heart Ra

2010
Exercise with hypoventilation induces lower muscle oxygenation and higher blood lactate concentration: role of hypoxia and hypercapnia.
    European journal of applied physiology, 2010, Volume: 110, Issue:2

    Topics: Adult; Bicycling; Carbon Dioxide; Ear; Exercise; Hemoglobins; Humans; Hypercapnia; Hypoventilation;

2010
Effects of erythropoietin administration on cerebral metabolism and exercise capacity in men.
    Journal of applied physiology (Bethesda, Md. : 1985), 2010, Volume: 109, Issue:2

    Topics: Adolescent; Adult; Biomarkers; Blood Flow Velocity; Blood Glucose; Blood-Brain Barrier; Brain; Cereb

2010
Blood lactate and pyruvate levels in the perioperative period of liver resection with Pringle maneuver.
    Clinical hemorheology and microcirculation, 2010, Volume: 44, Issue:4

    Topics: Bile Ducts; Blood Loss, Surgical; Constriction; Female; Hepatectomy; Hepatic Artery; Humans; Hypoxia

2010
Effect of intermittent hypoxia on muscle and cerebral oxygenation during a 20-km time trial in elite athletes: a preliminary report.
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2010, Volume: 35, Issue:4

    Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Carbon Dioxide; Cerebrovascular Circulation; Heart Rat

2010
Intermittent exercise with and without hypoxia improves insulin sensitivity in individuals with type 2 diabetes.
    The Journal of clinical endocrinology and metabolism, 2012, Volume: 97, Issue:4

    Topics: Algorithms; Blood Glucose; Cross-Over Studies; Deuterium; Diabetes Mellitus, Type 2; Exercise; Gluco

2012
The effects of hypoxia acclimation, exercise training and fasting on swimming performance in juvenile qingbo (Spinibarbus sinensis).
    Fish physiology and biochemistry, 2012, Volume: 38, Issue:5

    Topics: Acclimatization; Animals; Blood Glucose; Cyprinidae; Food Deprivation; Glycogen; Hypoxia; Lactic Aci

2012
Four weeks of normobaric "live high-train low" do not alter muscular or systemic capacity for maintaining pH and K⁺ homeostasis during intense exercise.
    Journal of applied physiology (Bethesda, Md. : 1985), 2012, Volume: 112, Issue:12

    Topics: Adult; Altitude; Bicarbonates; Carbon Dioxide; Double-Blind Method; Exercise; Exercise Test; Female;

2012
Short-term supplementation with alpha-ketoglutaric acid and 5-hydroxymethylfurfural does not prevent the hypoxia induced decrease of exercise performance despite attenuation of oxidative stress.
    International journal of sports medicine, 2013, Volume: 34, Issue:1

    Topics: Adult; Aldehydes; Altitude; Antioxidants; Athletic Performance; Double-Blind Method; Exercise; Exerc

2013
Thigh oxygen uptake at the onset of intense exercise is not affected by a reduction in oxygen delivery caused by hypoxia.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2012, Oct-15, Volume: 303, Issue:8

    Topics: Adult; Anaerobic Threshold; Analysis of Variance; Biopsy; Denmark; Double-Blind Method; Exercise; Ex

2012
Acute hypoxemia does not increase the oxidative stress in resting and contracting muscle in humans.
    Free radical research, 2002, Volume: 36, Issue:6

    Topics: Adult; Ascorbic Acid; Exercise Test; Humans; Hypoxia; Lactic Acid; Male; Muscle Contraction; Oxidati

2002
Why is VO2 max after altitude acclimatization still reduced despite normalization of arterial O2 content?
    American journal of physiology. Regulatory, integrative and comparative physiology, 2003, Volume: 284, Issue:2

    Topics: Acclimatization; Acid-Base Equilibrium; Adult; Altitude; Blood Circulation; Blood Gas Analysis; Card

2003
Effect of low oxygen inhalation on changes in blood pH, lactate, and ammonia due to exercise.
    European journal of applied physiology, 2004, Volume: 91, Issue:2-3

    Topics: Adult; Ammonia; Anaerobic Threshold; Blood Chemical Analysis; Carbon Dioxide; Exercise; Humans; Hydr

2004
Acute exposure to moderate high altitude decreases growth hormone response to physical exercise in untrained subjects.
    The Journal of sports medicine and physical fitness, 2003, Volume: 43, Issue:4

    Topics: Adult; Altitude; Exercise Test; Growth Hormone; Humans; Hypoxia; Insulin-Like Growth Factor I; Lacti

2003
Does exercise-induced hypoxemia modify lactate influx into erythrocytes and hemorheological parameters in athletes?
    Journal of applied physiology (Bethesda, Md. : 1985), 2004, Volume: 97, Issue:3

    Topics: Adaptation, Physiological; Adult; Blood Viscosity; Erythrocytes; Exercise Test; Hematocrit; Hemorheo

2004
Effects of acute hypoxia on the estimation of lactate threshold from ventilatory gas exchange indices during an incremental exercise test.
    Physiological research, 2004, Volume: 53, Issue:6

    Topics: Acute Disease; Adult; Anaerobic Threshold; Exercise Test; Humans; Hypoxia; Lactic Acid; Male; Oxygen

2004
Individual variation in the reduction of heart rate and performance at lactate thresholds in acute normobaric hypoxia.
    International journal of sports medicine, 2005, Volume: 26, Issue:7

    Topics: Adult; Altitude; Anaerobic Threshold; Exercise; Exercise Test; Heart Rate; Humans; Hypoxia; Lactic A

2005
Effect of exercise intensity and hypoxia on skeletal muscle AMPK signaling and substrate metabolism in humans.
    American journal of physiology. Endocrinology and metabolism, 2006, Volume: 290, Issue:4

    Topics: Adult; AMP-Activated Protein Kinases; Biopsy, Fine-Needle; Blood Glucose; Catecholamines; Energy Met

2006
Effects of purified oxygenated water on exercise performance during acute hypoxic exposure.
    International journal of sport nutrition and exercise metabolism, 2005, Volume: 15, Issue:6

    Topics: Administration, Oral; Adult; Altitude; Bicycling; Blood Gas Analysis; Body Weight; Cross-Over Studie

2005
Effects of exercise-induced arterial hypoxaemia on limb muscle fatigue and performance.
    Clinical and experimental pharmacology & physiology, 2006, Volume: 33, Issue:4

    Topics: Adult; Arteries; Bicycling; Exercise; Humans; Hypoxia; Lactic Acid; Muscle Fatigue; Muscle, Skeletal

2006
Effects of hypoxia on the onset of muscle deoxygenation and the lactate threshold.
    The journal of physiological sciences : JPS, 2006, Volume: 56, Issue:4

    Topics: Adult; Exercise; Female; Humans; Hypoxia; Lactic Acid; Male; Muscles; Oxygen; Oxygen Consumption; Sp

2006
The effects of hyperthermia and hypoxia on ventilation during low-intensity steady-state exercise.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2007, Volume: 292, Issue:1

    Topics: Adult; Body Temperature; Chemoreceptor Cells; Ergometry; Exercise; Fever; Hemoglobins; Humans; Hypox

2007
The influence of acute and 23 days of intermittent hypoxic exposures on the exercise-induced forehead sweating response.
    European journal of applied physiology, 2007, Volume: 99, Issue:5

    Topics: Acclimatization; Acute Disease; Adult; Altitude; Blood Pressure; Body Temperature Regulation; Chroni

2007
Adjusting oxygen fraction to avoid hyperoxemia during cardiopulmonary bypass.
    Asian cardiovascular & thoracic annals, 2007, Volume: 15, Issue:4

    Topics: Administration, Inhalation; Blood Gas Analysis; Carbon Dioxide; Cardiopulmonary Bypass; Coronary Art

2007
Does poor oxygenation during one-lung ventilation impair aerobic myocardial metabolism in patients with symptomatic coronary artery disease?
    Interactive cardiovascular and thoracic surgery, 2007, Volume: 6, Issue:2

    Topics: Aged; Anaerobic Threshold; Cardiopulmonary Bypass; Coronary Artery Bypass; Coronary Artery Disease;

2007
GXT responses in altitude-acclimatized cyclists during sea-level simulation.
    Medicine and science in sports and exercise, 2007, Volume: 39, Issue:10

    Topics: Acclimatization; Adult; Altitude; Bicycling; Colorado; Exercise; Exercise Test; Exhalation; Female;

2007
The effect of intermittent hypobaric hypoxic exposure and sea level training on submaximal economy in well-trained swimmers and runners.
    Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 104, Issue:2

    Topics: Acclimatization; Adult; Altitude; Double-Blind Method; Exercise; Female; Heart Rate; Humans; Hypoxia

2008
Improved running economy and increased hemoglobin mass in elite runners after extended moderate altitude exposure.
    Journal of science and medicine in sport, 2009, Volume: 12, Issue:1

    Topics: Altitude; Australia; Biomechanical Phenomena; Heart Rate; Hemoglobins; Humans; Hypoxia; Lactic Acid;

2009
[Young football players aerobic perfomance in sub-maximum exercise with exhaustion at a moderate altitude without acclimation: experience in El Condor].
    Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina), 2007, Volume: 64, Issue:1

    Topics: Acclimatization; Adolescent; Altitude; Anaerobic Threshold; Argentina; Biomarkers; Blood Glucose; Bo

2007
The ventilation, lactate and electromyographic thresholds during incremental exercise tests in normoxia, hypoxia and hyperoxia.
    European journal of applied physiology and occupational physiology, 1994, Volume: 69, Issue:2

    Topics: Adult; Anaerobic Threshold; Blood Gas Analysis; Carbon Dioxide; Chemoreceptor Cells; Electromyograph

1994
Gas exchange, blood lactate, and plasma catecholamines during incremental exercise in hypoxia and normoxia.
    Journal of applied physiology (Bethesda, Md. : 1985), 1995, Volume: 79, Issue:4

    Topics: Adult; Catecholamines; Exercise; Humans; Hypoxia; Lactates; Lactic Acid; Male; Oxygen Consumption; P

1995
Effect of inspired O2 concentration on leg lactate release during incremental exercise.
    Journal of applied physiology (Bethesda, Md. : 1985), 1996, Volume: 81, Issue:1

    Topics: Adult; Exercise; Exercise Test; Humans; Hypoxia; Lactic Acid; Leg; Male; Muscle, Skeletal; Oxygen Co

1996
The effect of altitude hypoxia on glucose homeostasis in men.
    The Journal of physiology, 1997, Oct-01, Volume: 504 ( Pt 1)

    Topics: Acclimatization; Adult; Altitude Sickness; Catecholamines; Exercise; Glucose; Glucose Clamp Techniqu

1997
The serum interleukin 8 level reflects hepatic mitochondrial redox state in hyperthermochemohypoxic isolated liver perfusion with use of a venovenous bypass.
    Surgery, 1999, Volume: 125, Issue:3

    Topics: Aged; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Combined Modality Therapy; Fe

1999
Intermittent hypobaric hypoxia induces altitude acclimation and improves the lactate threshold.
    Aviation, space, and environmental medicine, 2000, Volume: 71, Issue:2

    Topics: Acclimatization; Adult; Altitude Sickness; Anaerobic Threshold; Erythrocyte Count; Erythrocyte Indic

2000
Effect of acute hypoxia on vasopressin release and intravascular fluid during dynamic exercise in humans.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 279, Issue:1

    Topics: Acute Disease; Adult; Arginine Vasopressin; Blood Gas Analysis; Blood Pressure; Body Water; Body Wei

2000
Low-dose prostacyclin in treatment of severe brain trauma evaluated with microdialysis and jugular bulb oxygen measurements.
    Acta anaesthesiologica Scandinavica, 2000, Volume: 44, Issue:7

    Topics: Adult; Aged; Biomarkers; Brain Injuries; Energy Metabolism; Epoprostenol; Female; Humans; Hypoxia; J

2000
Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia.
    American journal of physiology. Endocrinology and metabolism, 2000, Volume: 279, Issue:4

    Topics: Acetyl Coenzyme A; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Adult; Bl

2000
Impaired interval exercise responses in elite female cyclists at moderate simulated altitude.
    Journal of applied physiology (Bethesda, Md. : 1985), 2000, Volume: 89, Issue:5

    Topics: Acids; Altitude; Bicarbonates; Bicycling; Double-Blind Method; Exercise Test; Female; Heart Rate; Hu

2000
Physical exercise and normobaric hypoxia: independent modulators of peripheral cholecystokinin metabolism in man.
    Journal of applied physiology (Bethesda, Md. : 1985), 2001, Volume: 90, Issue:1

    Topics: Adult; Amino Acids, Branched-Chain; Anthropometry; Atmospheric Pressure; Blood Glucose; Cholecystoki

2001
Physical training with and without oxygen in patients with chronic obstructive pulmonary disease and exercise-induced hypoxaemia.
    Journal of rehabilitation medicine, 2001, Volume: 33, Issue:5

    Topics: Aged; Carbon Dioxide; Exercise; Exercise Test; Exercise Therapy; Female; Humans; Hypoxia; Lactic Aci

2001
Increases in maximal accumulated oxygen deficit after high-intensity interval training are not gender dependent.
    Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 92, Issue:5

    Topics: Adult; Body Composition; Body Height; Body Weight; Exercise; Exercise Test; Female; Heart Rate; Huma

2002
The effect of sodium citrate intake on anaerobic performance in normoxia and after sudden ascent to a moderate altitude.
    The Journal of sports medicine and physical fitness, 2002, Volume: 42, Issue:2

    Topics: Adult; Altitude; Anaerobic Threshold; Citrates; Double-Blind Method; Exercise; Heart Rate; Humans; H

2002
The influence of pacing strategy on VO2 and supramaximal kayak performance.
    Medicine and science in sports and exercise, 2002, Volume: 34, Issue:6

    Topics: Adolescent; Adult; Competitive Behavior; Exercise; Humans; Hydrogen-Ion Concentration; Hypoxia; Lact

2002
Exercise-induced oxyhaemoglobin desaturation, ventilatory limitation and lung diffusing capacity in women during and after exercise.
    European journal of applied physiology, 2002, Volume: 87, Issue:2

    Topics: Adult; Arteries; Exercise; Exercise Test; Female; Humans; Hypoxia; Lactic Acid; Lung Volume Measurem

2002
Metabolic aspects of acute tissue hypoxia during extracorporeal circulation and their modification induced by L-carnitine treatment.
    International journal of clinical pharmacology research, 1992, Volume: 12, Issue:3

    Topics: Bicarbonates; Carnitine; Double-Blind Method; Extracorporeal Circulation; Female; Fumarates; Humans;

1992
Effect of hypoxia on psychomotor performance during graded exercise.
    Aviation, space, and environmental medicine, 1991, Volume: 62, Issue:3

    Topics: Adult; Exercise; Heart Rate; Humans; Hypoxia; Lactates; Lactic Acid; Psychomotor Performance

1991
Effect of dichloroacetate on ventilatory response to sustained hypoxia in normal adults.
    Respiration physiology, 1990, Volume: 82, Issue:1

    Topics: Adult; Brain; Dichloroacetic Acid; Female; Humans; Hypoxia; Lactates; Lactic Acid; Male; Respiration

1990

Other Studies

777 other studies available for lactic acid and Anoxemia

ArticleYear
Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia.
    Physiological reports, 2021, Volume: 9, Issue:18

    Topics: Adaptation, Physiological; Amino Acids; AMP-Activated Protein Kinase Kinases; Animals; Female; Glyco

2021
The bifunctional 6-phosphofructokinase-2/fructose-2,6-bisphosphatase from the shrimp Litopenaeus vannamei: Molecular characterization and down-regulation of expression in response to severe hypoxia.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2022, Volume: 263

    Topics: Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Down-Regulation; Gene Expression Re

2022
Increased air temperature during repeated-sprint training in hypoxia amplifies changes in muscle oxygenation without decreasing cycling performance.
    European journal of sport science, 2023, Volume: 23, Issue:1

    Topics: Athletic Performance; Exercise; Hot Temperature; Humans; Hypoxia; Lactic Acid; Male; Muscle, Skeleta

2023
Engineered l-Lactate Responding Promoter System Operating in Glucose-Rich and Anoxic Environments.
    ACS synthetic biology, 2021, 12-17, Volume: 10, Issue:12

    Topics: Biosensing Techniques; Gene Expression Regulation, Bacterial; Glucose; Humans; Hypoxia; Lactic Acid;

2021
Aquaporin family lactic acid channel NIP2;1 promotes plant survival under low oxygen stress in Arabidopsis.
    Plant physiology, 2021, 12-04, Volume: 187, Issue:4

    Topics: Adaptation, Physiological; Aquaporins; Arabidopsis; Gene Expression Regulation, Plant; Genes, Plant;

2021
Lactate inhibits naked mole-rat cardiac mitochondrial respiration.
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2022, Volume: 192, Issue:3-4

    Topics: Adenosine Triphosphate; Animals; Cell Respiration; Hypoxia; Lactic Acid; Mitochondria, Heart; Mole R

2022
Monocarboxylate transporter 1-mediated lactate accumulation promotes nucleus pulposus degeneration under hypoxia in a 3D multilayered nucleus pulposus degeneration model.
    European cells & materials, 2022, 02-21, Volume: 43

    Topics: Glycosaminoglycans; Humans; Hypoxia; Intervertebral Disc Degeneration; Lactic Acid; Matrix Metallopr

2022
TRIM72 exerts antitumor effects in breast cancer and modulates lactate production and MCT4 promoter activity by interacting with PPP3CA.
    Anti-cancer drugs, 2022, 06-01, Volume: 33, Issue:5

    Topics: Breast Neoplasms; Calcineurin; Cell Line, Tumor; Cell Proliferation; Female; Humans; Hypoxia; Lactic

2022
The
    International journal of molecular sciences, 2022, Mar-19, Volume: 23, Issue:6

    Topics: Animals; Down-Regulation; Glucose; Glycolysis; Humans; Hyperglycemia; Hypoxia; Hypoxia-Inducible Fac

2022
[CLINICAL CASE OF ACUTE SEVERE COMBINED POISONING WITH NARCOTIC SUBSTANCES OF DEPENDENT AND PSYCHOSTIMULATING EFFECTS].
    Georgian medical news, 2022, Issue:324

    Topics: Adult; Coma; Cross Infection; Humans; Hypoxia; Lactic Acid; Methadone; Narcotics

2022
TGF-β1 induced autophagy in cancer associated fibroblasts during hypoxia contributes EMT and glycolysis via MCT4 upregulation.
    Experimental cell research, 2022, 08-01, Volume: 417, Issue:1

    Topics: Animals; Autophagy; Cancer-Associated Fibroblasts; Gene Expression Regulation, Neoplastic; Glycolysi

2022
Alcohol-Induced Glycolytic Shift in Alveolar Macrophages Is Mediated by Hypoxia-Inducible Factor-1 Alpha.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Animals; Ethanol; Glucose Transporter Type 1; Glycolysis; Hypoxia; Lactic Acid; Macrophages, Alveola

2022
Ultrastable Lactate Biosensor Linearly Responding in Whole Sweat for Noninvasive Monitoring of Hypoxia.
    Analytical chemistry, 2022, 06-28, Volume: 94, Issue:25

    Topics: Biosensing Techniques; Humans; Hypoxia; Lactic Acid; Sweat; Wearable Electronic Devices

2022
Mitochondrial oxidative phosphorylation became functional under aglycemic hypoxia conditions in A549 cells.
    Molecular biology reports, 2022, Volume: 49, Issue:9

    Topics: A549 Cells; Adenosine Triphosphate; Cell Hypoxia; Citrate (si)-Synthase; Glucose; Glycolysis; Humans

2022
Changes in metabolic profiling of whiteleg shrimp (Penaeus vannamei) under hypoxic stress.
    Journal of invertebrate pathology, 2022, Volume: 193

    Topics: Animals; Aquaculture; Biomarkers; Hypoxia; Lactic Acid; Penaeidae

2022
Lactate promotes metastasis of normoxic colorectal cancer stem cells through PGC-1α-mediated oxidative phosphorylation.
    Cell death & disease, 2022, 07-27, Volume: 13, Issue:7

    Topics: Cell Line; Colorectal Neoplasms; Humans; Hypoxia; Lactic Acid; Neoplastic Stem Cells; Oxidative Phos

2022
Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia.
    eLife, 2022, 08-09, Volume: 11

    Topics: Animals; Animals, Newborn; Brain; Hypoxia; Ischemia; Lactic Acid; Mice; Mice, Knockout; Microglia; N

2022
Predicting postoperative hypoxemia risk factors in the patients after triple-branched stent graft implantation surgery with acute type A aortic dissection: A retrospective study.
    Journal of cardiac surgery, 2022, Volume: 37, Issue:11

    Topics: Aortic Dissection; Creatinine; Humans; Hypoxia; Lactic Acid; Retrospective Studies; Risk Factors; St

2022
Effects of Sports Functional Food on Physical Function of Athletes under Ultrasound Observation.
    Scanning, 2022, Volume: 2022

    Topics: Animals; Antlers; Athletes; Deer; Functional Food; Hemoglobins; Humans; Hypoxia; Lactic Acid; Polyam

2022
The novel prolyl hydroxylase-2 inhibitor caffeic acid upregulates hypoxia inducible factor and protects against hypoxia.
    European journal of pharmacology, 2022, Nov-05, Volume: 934

    Topics: Animals; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Prolin

2022
Lactate-dependent chaperone-mediated autophagy induces oscillatory HIF-1α activity promoting proliferation of hypoxic cells.
    Cell systems, 2022, 12-21, Volume: 13, Issue:12

    Topics: Cell Line, Tumor; Cell Proliferation; Chaperone-Mediated Autophagy; Humans; Hypoxia; Lactic Acid

2022
Lactate-dependent chaperone-mediated autophagy induces oscillatory HIF-1α activity promoting proliferation of hypoxic cells.
    Cell systems, 2022, 12-21, Volume: 13, Issue:12

    Topics: Cell Line, Tumor; Cell Proliferation; Chaperone-Mediated Autophagy; Humans; Hypoxia; Lactic Acid

2022
Lactate-dependent chaperone-mediated autophagy induces oscillatory HIF-1α activity promoting proliferation of hypoxic cells.
    Cell systems, 2022, 12-21, Volume: 13, Issue:12

    Topics: Cell Line, Tumor; Cell Proliferation; Chaperone-Mediated Autophagy; Humans; Hypoxia; Lactic Acid

2022
Lactate-dependent chaperone-mediated autophagy induces oscillatory HIF-1α activity promoting proliferation of hypoxic cells.
    Cell systems, 2022, 12-21, Volume: 13, Issue:12

    Topics: Cell Line, Tumor; Cell Proliferation; Chaperone-Mediated Autophagy; Humans; Hypoxia; Lactic Acid

2022
O
    ACS applied materials & interfaces, 2022, Dec-28, Volume: 14, Issue:51

    Topics: Animals; Cell Line, Tumor; Hydrogen Peroxide; Hypoxia; Lactic Acid; Mice; Nanoparticles; Neoplasms;

2022
O
    ACS applied materials & interfaces, 2022, Dec-28, Volume: 14, Issue:51

    Topics: Animals; Cell Line, Tumor; Hydrogen Peroxide; Hypoxia; Lactic Acid; Mice; Nanoparticles; Neoplasms;

2022
O
    ACS applied materials & interfaces, 2022, Dec-28, Volume: 14, Issue:51

    Topics: Animals; Cell Line, Tumor; Hydrogen Peroxide; Hypoxia; Lactic Acid; Mice; Nanoparticles; Neoplasms;

2022
O
    ACS applied materials & interfaces, 2022, Dec-28, Volume: 14, Issue:51

    Topics: Animals; Cell Line, Tumor; Hydrogen Peroxide; Hypoxia; Lactic Acid; Mice; Nanoparticles; Neoplasms;

2022
Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology.
    Journal of medicinal chemistry, 2023, 01-12, Volume: 66, Issue:1

    Topics: Antineoplastic Agents; Humans; Hypoxia; Lactic Acid; Monocarboxylic Acid Transporters; Neoplasms; Sy

2023
Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology.
    Journal of medicinal chemistry, 2023, 01-12, Volume: 66, Issue:1

    Topics: Antineoplastic Agents; Humans; Hypoxia; Lactic Acid; Monocarboxylic Acid Transporters; Neoplasms; Sy

2023
Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology.
    Journal of medicinal chemistry, 2023, 01-12, Volume: 66, Issue:1

    Topics: Antineoplastic Agents; Humans; Hypoxia; Lactic Acid; Monocarboxylic Acid Transporters; Neoplasms; Sy

2023
Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology.
    Journal of medicinal chemistry, 2023, 01-12, Volume: 66, Issue:1

    Topics: Antineoplastic Agents; Humans; Hypoxia; Lactic Acid; Monocarboxylic Acid Transporters; Neoplasms; Sy

2023
Acidic and hypoxic tumor microenvironment regulation by CaO
    Journal of nanobiotechnology, 2022, Dec-28, Volume: 20, Issue:1

    Topics: Cell Line, Tumor; Humans; Hypoxia; Lactic Acid; Nanoparticles; Tumor Microenvironment

2022
Hypoxia Does Not Change Performance and Psychophysiological Responses During Repeated Cycling Sprints to Exhaustion With Short Exercise-to-Rest Ratio.
    International journal of sports physiology and performance, 2023, Feb-01, Volume: 18, Issue:2

    Topics: Athletic Performance; Exercise; Humans; Hypoxia; Lactic Acid; Oxygen; Oxygen Consumption; Quadriceps

2023
Hypoxia enhances IPF mesenchymal progenitor cell fibrogenicity via the lactate/GPR81/HIF1α pathway.
    JCI insight, 2023, 02-22, Volume: 8, Issue:4

    Topics: Humans; Hypoxia; Idiopathic Pulmonary Fibrosis; Lactic Acid; Mesenchymal Stem Cells; Signal Transduc

2023
Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction.
    Science advances, 2023, 02-03, Volume: 9, Issue:5

    Topics: Endothelial Cells; Fibrosis; Humans; Hypoxia; Lactic Acid; Myocardial Infarction; Transforming Growt

2023
Monocarboxylate transporter-dependent mechanism is involved in the adaptability of the body to exercise-induced fatigue under high-altitude hypoxia environment.
    Brain research bulletin, 2023, Volume: 195

    Topics: Altitude; Altitude Sickness; Animals; Fatigue; Hypoxia; Lactic Acid; Rats

2023
A monocarboxylate transporter-dependent mechanism confers resistance to exercise-induced fatigue in a high-altitude hypoxic environment.
    Scientific reports, 2023, 02-20, Volume: 13, Issue:1

    Topics: Altitude; Animals; Brain; Fatigue; Hypoxia; Lactic Acid; Membrane Transport Proteins; Rats

2023
Different reoxygenation rates induce different metabolic, apoptotic and immune responses in Golden Pompano (Trachinotus blochii) after hypoxic stress.
    Fish & shellfish immunology, 2023, Volume: 135

    Topics: Animals; Cell Hypoxia; Fishes; Hypoxia; Immunity; Lactic Acid; Oxygen

2023
Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation.
    Molecular neurodegeneration, 2023, 03-07, Volume: 18, Issue:1

    Topics: Glucose; Humans; Hypoxia; Lactic Acid; Oxidative Phosphorylation; Retinal Degeneration; Retinal Rod

2023
[Effects of blocking lactate production by 2-DG on hypoxic injury of HT22 neurons and its mechanisms].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2022, Volume: 38, Issue:5

    Topics: Apoptosis; Deoxyglucose; Humans; Hypoxia; Lactic Acid; Neurons; Oxidative Stress; Reactive Oxygen Sp

2022
Energy metabolic mechanisms for high altitude sickness: Downregulation of glycolysis and upregulation of the lactic acid/amino acid-pyruvate-TCA pathways and fatty acid oxidation.
    The Science of the total environment, 2023, Oct-10, Volume: 894

    Topics: Altitude; Altitude Sickness; Amino Acids; Animals; Citric Acid Cycle; Down-Regulation; Fatty Acids;

2023
Promotion of NAD
    Free radical biology & medicine, 2023, 11-01, Volume: 208

    Topics: Bone Marrow; Cellular Senescence; Endothelial Progenitor Cells; Humans; Hypoxia; Isoenzymes; L-Lacta

2023
HIF-1α drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1.
    Cell reports, 2023, 08-29, Volume: 42, Issue:8

    Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Excitatory Amino Acid Transporter 3; Ferroptosis; Hypoxia;

2023
Fetal Oxygenation from the 23rd to the 36th Week of Gestation Evaluated through the Umbilical Cord Blood Gas Analysis.
    International journal of molecular sciences, 2023, Aug-06, Volume: 24, Issue:15

    Topics: Female; Fetal Blood; Fetus; Humans; Hypoxia; Infant; Infant, Newborn; Lactic Acid; Oxygen; Pregnancy

2023
S-Adenosylhomocysteine Is a Useful Metabolic Factor in the Early Prediction of Septic Disease Progression and Death in Critically Ill Patients: A Prospective Cohort Study.
    International journal of molecular sciences, 2023, Aug-09, Volume: 24, Issue:16

    Topics: Critical Illness; Disease Progression; Humans; Hypoxia; Lactic Acid; Multiple Organ Failure; Oxygen;

2023
Effect of Diosmin on Selected Parameters of Oxygen Homeostasis.
    International journal of molecular sciences, 2023, Aug-18, Volume: 24, Issue:16

    Topics: Cardiovascular Diseases; Diosmin; Fibroblast Growth Factors; Homeostasis; Humans; Hypoxia; Inflammat

2023
Relative hypoxemia at depth during breath-hold diving investigated through arterial blood gas analysis and lung ultrasound.
    Journal of applied physiology (Bethesda, Md. : 1985), 2023, 10-01, Volume: 135, Issue:4

    Topics: Blood Gas Analysis; Carbon Dioxide; Diving; Edema; Humans; Hypoxia; Lactic Acid; Oxygen; Pulmonary A

2023
Persistent hypoxia promotes myofibroblast differentiation via GPR-81 and differential regulation of LDH isoenzymes in normal and idiopathic pulmonary fibrosis fibroblasts.
    Physiological reports, 2023, Volume: 11, Issue:17

    Topics: Fibroblasts; Humans; Hypoxia; Idiopathic Pulmonary Fibrosis; Isoenzymes; L-Lactate Dehydrogenase; La

2023
3, 3'-diindolylmethane, a natural aryl hydrocarbon receptor agonist, alleviates ulcerative colitis by enhancing "glycolysis-lactate-STAT3″ and TIP60 signals-mediated Treg differentiation.
    Molecular immunology, 2023, Volume: 163

    Topics: Animals; Cell Differentiation; Colitis; Colitis, Ulcerative; Forkhead Transcription Factors; Glucose

2023
Hypoxia-sensing VGLL4 promotes LDHA-driven lactate production to ameliorate neuronal dysfunction in a cellular model relevant to Alzheimer's disease.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2023, Volume: 37, Issue:12

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Hypoxia; Lactic A

2023
Microenvironmental stress drives tumor cell maladaptation and malignancy through regulation of mitochondrial and nuclear cytochrome c oxidase subunits.
    American journal of physiology. Cell physiology, 2023, 12-01, Volume: 325, Issue:6

    Topics: Electron Transport Complex IV; Glucose; Humans; Hypoxia; Lactic Acid; Neoplasms; Tumor Microenvironm

2023
IFN-γ lowers tumor growth by increasing glycolysis and lactate production in a nitric oxide-dependent manner: implications for cancer immunotherapy.
    Frontiers in immunology, 2023, Volume: 14

    Topics: Cell Line, Tumor; Glycolysis; Humans; Hypoxia; Interferon-gamma; Lactic Acid; Neoplasms; Nitric Oxid

2023
Absolute expressions of hypoxia-inducible factor-1 alpha (HIF1A) transcript and the associated genes in chicken skeletal muscle with white striping and wooden breast myopathies.
    PloS one, 2019, Volume: 14, Issue:8

    Topics: Animals; Chickens; Gene Expression Regulation; Glycogen; Hydrogen-Ion Concentration; Hypoxia; Hypoxi

2019
Polycyclic aromatic hydrocarbon and hypoxia exposures result in mitochondrial dysfunction in zebrafish.
    Aquatic toxicology (Amsterdam, Netherlands), 2019, Volume: 216

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Area Under Curve; Embryo, Nonmammalian; Ener

2019
Metabolic regulation of gene expression by histone lactylation.
    Nature, 2019, Volume: 574, Issue:7779

    Topics: Acetylation; Amino Acid Sequence; Animals; Cell Line, Tumor; Chromatin; Epigenesis, Genetic; Glycoly

2019
Cardiac Autonomic and Physiological Responses to Moderate- intensity Exercise in Hypoxia.
    International journal of sports medicine, 2019, Volume: 40, Issue:14

    Topics: Adult; Autonomic Nervous System; Exercise; Heart; Heart Rate; Humans; Hypoxia; Lactic Acid; Male; Ox

2019
Intermittent Hypoxic Training at Lactate Threshold Intensity Improves Aiming Performance in Well-Trained Biathletes with Little Change of Cardiovascular Variables.
    BioMed research international, 2019, Volume: 2019

    Topics: Adolescent; Athletes; Cardiovascular System; Exercise; Exercise Test; Exercise Tolerance; Humans; Hy

2019
MicroRNA-124 regulates lactate transportation in the muscle of largemouth bass (micropterus salmoides) under hypoxia by targeting MCT1.
    Aquatic toxicology (Amsterdam, Netherlands), 2020, Volume: 218

    Topics: Acclimatization; Animals; Bass; Carbohydrate Metabolism; Gene Expression Regulation; Hypoxia; Lactic

2020
Influence of 96h sub-lethal copper exposure on aerobic scope and recovery from exhaustive exercise in killifish (Fundulus heteroclitus).
    Aquatic toxicology (Amsterdam, Netherlands), 2020, Volume: 218

    Topics: Acclimatization; Anaerobiosis; Animals; Copper; Ecosystem; Fresh Water; Fundulidae; Glycogen; Hypoxi

2020
The hypoxia-lactate axis tempers inflammation.
    Nature reviews. Immunology, 2020, Volume: 20, Issue:2

    Topics: Glycolysis; Histone Code; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation;

2020
Hypoxic-ischemic enterocolitis: a proposal of a new terminology for early NEC or NEC-like disease in preterm infants, a single-center prospective observational study.
    European journal of pediatrics, 2020, Volume: 179, Issue:4

    Topics: Biomarkers; Case-Control Studies; Enterocolitis, Necrotizing; Fatty Acid-Binding Proteins; Female; F

2020
A genetic toolkit for the analysis of metabolic changes in Drosophila provides new insights into metabolic responses to stress and malignant transformation.
    Scientific reports, 2019, 12-27, Volume: 9, Issue:1

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Drosophila melanogas

2019
Serum Autofluorescence and Biochemical Markers in Athlete's Response to Strength Effort in Normobaric Hypoxia: A Preliminary Study.
    BioMed research international, 2019, Volume: 2019

    Topics: Adult; Altitude; Athletes; Biomarkers; Creatine Kinase; Exercise; Humans; Hypoxia; Lactic Acid; Male

2019
[Effects of the Fomes officinalis Ames. polysaccharides on anti-fatigue and hypoxia tolerance in mice].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2019, Volume: 35, Issue:5

    Topics: Animals; Blood Urea Nitrogen; Coriolaceae; Fatigue; Glycogen; Hypoxia; Lactic Acid; Liver; Mice; Pla

2019
Autonomic response to fetal acidosis using an experimental sheep model.
    European journal of obstetrics, gynecology, and reproductive biology, 2020, Volume: 246

    Topics: Acidosis; Animals; Autonomic Nervous System; Blood Gas Analysis; Constriction; Female; Fetal Monitor

2020
Nrf2 Activation Enhances Muscular MCT1 Expression and Hypoxic Exercise Capacity.
    Medicine and science in sports and exercise, 2020, Volume: 52, Issue:8

    Topics: Activating Transcription Factor 3; Animals; Basigin; Energy Metabolism; Hypoxia; Hypoxia-Inducible F

2020
Altered Cerebral Blood Flow and Potential Neuroprotective Effect of Human Relaxin-2 (Serelaxin) During Hypoxia or Severe Hypovolemia in a Sheep Model.
    International journal of molecular sciences, 2020, Feb-27, Volume: 21, Issue:5

    Topics: Animals; Arterioles; Brain; Cerebrovascular Circulation; Disease Models, Animal; Hypovolemia; Hypoxi

2020
Neuromuscular Fatigue of Cycling Exercise in Hypoxia.
    Medicine and science in sports and exercise, 2020, Volume: 52, Issue:9

    Topics: Adult; Bicycling; Electromyography; Ergometry; Evoked Potentials, Motor; Fatigue; Humans; Hypoxia; K

2020
Can COVID-19 cause myalgia with a completely different mechanism? A hypothesis.
    Clinical rheumatology, 2020, Volume: 39, Issue:7

    Topics: Betacoronavirus; Coronavirus Infections; COVID-19; Humans; Hypoxia; L-Lactate Dehydrogenase; Lactic

2020
Computational modeling to determine key regulators of hypoxia effects on the lactate production in the glycolysis pathway.
    Scientific reports, 2020, 06-08, Volume: 10, Issue:1

    Topics: Gene Expression; Glycolysis; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lactic Acid

2020
A Metabolomics Study of Hypoxia Ischemia during Mouse Brain Development Using Hyperpolarized 13C.
    Developmental neuroscience, 2020, Volume: 42, Issue:1

    Topics: Animals; Brain; Carbon Isotopes; Hypoxia; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonanc

2020
Openwork@Dendritic Mesoporous Silica Nanoparticles for Lactate Depletion and Tumor Microenvironment Regulation.
    Angewandte Chemie (International ed. in English), 2020, 12-01, Volume: 59, Issue:49

    Topics: Angiogenesis Inhibitors; Animals; Anthraquinones; Antineoplastic Agents; Breast Neoplasms; Cell Line

2020
Lactate Administration Reduces Brain Injury and Ameliorates Behavioral Outcomes Following Neonatal Hypoxia-Ischemia.
    Neuroscience, 2020, 11-10, Volume: 448

    Topics: Animals; Animals, Newborn; Brain; Brain Injuries; Disease Models, Animal; Female; Hypoxia; Hypoxia-I

2020
Carbohydrate Supplementation and the Influence of Breakfast on Fuel Use in Hypoxia.
    Medicine and science in sports and exercise, 2021, 04-01, Volume: 53, Issue:4

    Topics: Blood Glucose; Breakfast; Breath Tests; Calorimetry, Indirect; Dietary Carbohydrates; Dietary Supple

2021
No Influence of Acute Moderate Normobaric Hypoxia on Performance and Blood Lactate Concentration Responses to Repeated Wingates.
    International journal of sports physiology and performance, 2021, 01-01, Volume: 16, Issue:1

    Topics: Athletic Performance; Exercise Test; Humans; Hypoxia; Lactic Acid; Male; Oxygen Consumption; Physica

2021
Salbutamol-induced lactic acidosis in status asthmaticus survivor.
    BMC pulmonary medicine, 2021, Jan-12, Volume: 21, Issue:1

    Topics: Acidosis; Acidosis, Lactic; Acidosis, Respiratory; Adrenergic beta-2 Receptor Agonists; Adult; Albut

2021
Negative central venous to arterial lactate gradient in patients receiving vasopressors is associated with higher ICU 30-day mortality: a retrospective cohort study.
    BMC anesthesiology, 2021, 01-22, Volume: 21, Issue:1

    Topics: Aged; Arteries; Beijing; Cohort Studies; Critical Care; Critical Illness; Female; Hospital Mortality

2021
Diagnostic challenge: an atypical presentation of infective endocarditis.
    BMJ case reports, 2021, Jan-25, Volume: 14, Issue:1

    Topics: Bacteremia; Blood Culture; C-Reactive Protein; Diagnosis, Differential; Diarrhea; Dysentery; Early W

2021
Severely High Lactic Acid in Severe Pneumonia Patient: a Case Report.
    Clinical laboratory, 2021, Mar-01, Volume: 67, Issue:3

    Topics: Humans; Hypoxia; Lactic Acid; Pneumonia

2021
Hypoxia tolerance and metabolic coping strategies in Oreochromis niloticus.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2021, Volume: 257

    Topics: Acidosis; Adaptation, Psychological; Anaerobiosis; Animals; Aquaculture; Blood Glucose; Cichlids; Gi

2021
No Influence of Nonivamide-nicoboxil on the Peak Power Output in Competitive Sportsmen.
    International journal of sports medicine, 2021, Volume: 42, Issue:12

    Topics: Administration, Cutaneous; Adult; Athletic Performance; Capsaicin; Cross-Over Studies; Exercise Test

2021
Extreme hypoxia and high lactate concentrations in early chicken embryos show that cutaneous oxygen uptake is limited by diffusion and metabolism is partially anaerobic.
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2021, Volume: 191, Issue:6

    Topics: Anaerobiosis; Animals; Chick Embryo; Chickens; Hypoxia; Lactic Acid; Oxygen

2021
In Vitro Evaluation of CD276-CAR NK-92 Functionality, Migration and Invasion Potential in the Presence of Immune Inhibitory Factors of the Tumor Microenvironment.
    Cells, 2021, 04-26, Volume: 10, Issue:5

    Topics: Antigens, Neoplasm; B7 Antigens; Cell Line, Tumor; Cell Movement; CRISPR-Cas Systems; Cytotoxicity,

2021
Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males.
    Bioscience reports, 2021, 07-30, Volume: 41, Issue:7

    Topics: Adolescent; Adult; Biomarkers; Down-Regulation; Endotoxemia; Healthy Volunteers; Humans; Hypoxia; In

2021
Lactate sensing mechanisms in arterial chemoreceptor cells.
    Nature communications, 2021, 07-06, Volume: 12, Issue:1

    Topics: Animals; Arteries; Carotid Body; Chemoreceptor Cells; Homeostasis; Hydrogen-Ion Concentration; Hypox

2021
Protective effect of 5,6,7,8-trtrahydroxyflavone against acute hypobaric hypoxia induced-oxidative stress in mice.
    Pakistan journal of pharmaceutical sciences, 2021, Volume: 34, Issue:2

    Topics: Animals; Blood Pressure; Brain; Flavones; Heart; Heart Rate; Hydrogen Peroxide; Hypoxia; L-Lactate D

2021
Hypoxia‑induced lactate dehydrogenase A protects cells from apoptosis in endometriosis.
    Molecular medicine reports, 2021, Volume: 24, Issue:3

    Topics: Adult; Apoptosis; Cell Proliferation; Endometriosis; Endometrium; Epithelial Cells; Epithelial-Mesen

2021
Effects of Acute Hypoxia on Lactate Thresholds and High-Intensity Endurance Performance-A Pilot Study.
    International journal of environmental research and public health, 2021, 07-16, Volume: 18, Issue:14

    Topics: Altitude; Exercise; Exercise Test; Humans; Hypoxia; Lactic Acid; Oxygen Consumption; Physical Endura

2021
Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis.
    Cell metabolism, 2021, 10-05, Volume: 33, Issue:10

    Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Gastrointestinal Microbiome; Hypoxia; Lactic

2021
Human Cerebral Perfusion, Oxygen Consumption, and Lactate Production in Response to Hypoxic Exposure.
    Cerebral cortex (New York, N.Y. : 1991), 2022, 03-04, Volume: 32, Issue:6

    Topics: Brain; Cerebrovascular Circulation; Humans; Hypoxia; Lactic Acid; Oxygen; Oxygen Consumption

2022
Impact of Endurance Exercise in Hypoxia on Muscle Damage, Inflammatory and Performance Responses.
    Journal of strength and conditioning research, 2018, Volume: 32, Issue:4

    Topics: Adult; Athletes; Biomarkers; Energy Metabolism; Exercise Test; High-Intensity Interval Training; Hum

2018
The physiological and molecular response of Aurelia sp.1 under hypoxia.
    Scientific reports, 2017, 05-08, Volume: 7, Issue:1

    Topics: Animals; Gene Expression Regulation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; L-Lactate D

2017
Overexpression of pyruvate dehydrogenase kinase 1 in retinoblastoma: A potential therapeutic opportunity for targeting vitreous seeds and hypoxic regions.
    PloS one, 2017, Volume: 12, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dichloroaceti

2017
Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors.
    BMC cancer, 2017, Jun-15, Volume: 17, Issue:1

    Topics: Adenosine Triphosphate; Animals; Biomarkers; Cell Line, Tumor; Disease Models, Animal; Energy Metabo

2017
The high tolerance to aluminium in crucian carp (Carassius carassius) is associated with its ability to avoid hypoxia.
    PloS one, 2017, Volume: 12, Issue:6

    Topics: Adaptation, Physiological; Aluminum; Animals; Carps; Cetylpyridinium; Electric Conductivity; Ethanol

2017
Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression.
    Scientific reports, 2017, 06-27, Volume: 7, Issue:1

    Topics: Acriflavine; Animals; Basigin; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Disease

2017
Acute physiological and perceptual responses to high-load resistance exercise in hypoxia.
    Clinical physiology and functional imaging, 2018, Volume: 38, Issue:4

    Topics: Adult; Biomarkers; Energy Metabolism; Humans; Hypoxia; Lactic Acid; Male; Muscle Contraction; Muscle

2018
Two common variants of human papillomavirus type 16 E6 differentially deregulate sugar metabolism and hypoxia signalling in permissive human keratinocytes.
    The Journal of general virology, 2017, Volume: 98, Issue:9

    Topics: Glucose; Host-Pathogen Interactions; Human papillomavirus 16; Humans; Hypoxia; Hypoxia-Inducible Fac

2017
Attenuation of
    Bioscience reports, 2017, Dec-22, Volume: 37, Issue:6

    Topics: 3' Untranslated Regions; Animals; Apoptosis; Base Sequence; Cell Hypoxia; Cell Line; Cell Survival;

2017
The Collocation of Ischemia-Modified Albumin and Blood Gas Parameters in the PICU Setting.
    Clinical pediatrics, 2018, Volume: 57, Issue:4

    Topics: Biomarkers; Blood Gas Analysis; Carbon Dioxide; Child; Female; Humans; Hypoxia; Intensive Care Units

2018
N-acetylcysteine effects on a murine model of chronic critical limb ischemia.
    Biochimica et biophysica acta. Molecular basis of disease, 2018, Volume: 1864, Issue:2

    Topics: Acetylcysteine; Animals; Disease Models, Animal; Hindlimb; Hypoxia; Hypoxia-Inducible Factor 1, alph

2018
Cerebral metabolism and vascular reactivity during breath-hold and hypoxic challenge in freedivers and healthy controls.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019, Volume: 39, Issue:5

    Topics: Adult; Brain; Breath Holding; Cerebrovascular Circulation; Diving; Female; Glycolysis; Humans; Hypox

2019
The comparison of umbilical cord arterial blood lactate and pH values for predicting short-term neonatal outcomes.
    Taiwanese journal of obstetrics & gynecology, 2017, Volume: 56, Issue:6

    Topics: Apgar Score; Female; Fetal Blood; Humans; Hydrogen-Ion Concentration; Hypoxia; Infant, Newborn; Infa

2017
Cerebral blood flow, oxygen metabolism, and lactate during hypoxia in patients with obstructive sleep apnea.
    Sleep, 2018, 03-01, Volume: 41, Issue:3

    Topics: Adult; Biomarkers; Cerebrovascular Circulation; Continuous Positive Airway Pressure; Female; Humans;

2018
Comparison of changes in mitochondrial bioenergetics between keratinocytes in human external auditory canal skin and cholesteatomas from normoxia to hypoxia.
    Scientific reports, 2018, 01-09, Volume: 8, Issue:1

    Topics: Adenosine Triphosphate; Autophagy; Cell Proliferation; Cell Respiration; Cell Survival; Cells, Cultu

2018
Eryptosis and hemorheological responses to maximal exercise in athletes: Comparison between running and cycling.
    Scandinavian journal of medicine & science in sports, 2018, Volume: 28, Issue:5

    Topics: Adult; Bicycling; Blood Glucose; Blood Viscosity; Calcium; Eryptosis; Erythrocyte Deformability; Fem

2018
Metabolic reprogramming of Kaposi's sarcoma associated herpes virus infected B-cells in hypoxia.
    PLoS pathogens, 2018, Volume: 14, Issue:5

    Topics: B-Lymphocytes; Blotting, Western; Gene Expression Regulation, Viral; Glucose; Herpesvirus 8, Human;

2018
High-performance reoxygenation from PLGA-PEG/PFOB emulsions: a feedback relationship between ROS and HIF-1α.
    International journal of nanomedicine, 2018, Volume: 13

    Topics: A549 Cells; Acute Lung Injury; Animals; Cell Hypoxia; Cell Survival; Drug Delivery Systems; Emulsion

2018
Neurological impairments in hypoxic neonates and lactate levels.
    Neurological research, 2018, Volume: 40, Issue:10

    Topics: Acidosis; Age Factors; Blood Gas Analysis; Female; Gestational Age; Humans; Hypoxia; Infant, Newborn

2018
Effect of environmental feedbacks on pacing strategy and affective load during a self-paced 30 min cycling time trial.
    Journal of sports sciences, 2019, Volume: 37, Issue:3

    Topics: Adult; Affect; Altitude; Athletes; Athletic Performance; Bicycling; Feedback, Psychological; Heart R

2019
Effects of tumor necrosis factor-α-induced exosomes on the endothelial cellular behavior, metabolism and bioenergetics.
    Microcirculation (New York, N.Y. : 1994), 2019, Volume: 26, Issue:1

    Topics: Apoptosis; Cell Movement; Cells, Cultured; Energy Metabolism; Exosomes; Glycolysis; Human Umbilical

2019
The Post-Exercise Inflammatory Response to Repeated-Sprint Running in Hypoxia.
    Journal of sports science & medicine, 2018, Volume: 17, Issue:4

    Topics: Adult; Altitude; Athletes; Humans; Hypoxia; Inflammation; Interleukins; Lactic Acid; Running; Young

2018
Distinct metabolic adjustments arise from acclimation to constant hypoxia and intermittent hypoxia in estuarine killifish (
    The Journal of experimental biology, 2018, 12-05, Volume: 221, Issue:Pt 23

    Topics: Acclimatization; Anaerobiosis; Animals; Fundulidae; Glucose; Glycogen; Hydrogen-Ion Concentration; H

2018
Development of Inflammatory Hypoxia and Prevalence of Glycolytic Metabolism in Progressing Herpes Stromal Keratitis Lesions.
    Journal of immunology (Baltimore, Md. : 1950), 2019, 01-15, Volume: 202, Issue:2

    Topics: Acriflavine; Active Transport, Cell Nucleus; Animals; Anti-Infective Agents, Local; Basic Helix-Loop

2019
Potential metabolic markers in glaucoma and their regulation in response to hypoxia.
    Acta ophthalmologica, 2019, Volume: 97, Issue:6

    Topics: Aged; Amino Acids; Biomarkers; Blood Glucose; Chromatography, High Pressure Liquid; Female; Glaucoma

2019
50 Years Ago in The Journal of Pediatrics: Acid-Base Monitoring of the Fetus during Labor with Blood Obtained from the Scalp.
    The Journal of pediatrics, 2019, Volume: 208

    Topics: Acid-Base Equilibrium; Acidosis; Blood Specimen Collection; Female; Fetal Diseases; Fetal Monitoring

2019
Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI.
    Neuro-oncology, 2019, 09-06, Volume: 21, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain Neoplasms; Echo-Planar Imaging; Female; Glioma; Gl

2019
High Intrarenal Lactate Production Inhibits the Renal Pseudohypoxic Response to Acutely Induced Hypoxia in Diabetes.
    Tomography (Ann Arbor, Mich.), 2019, Volume: 5, Issue:2

    Topics: Acute Disease; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Hypoxia; Ki

2019
Coping with exposure to hypoxia: modifications in stress parameters in gilthead seabream (Sparus aurata) fed spirulina (Arthrospira platensis) and brewer's yeast (Saccharomyces cerevisiae).
    Fish physiology and biochemistry, 2019, Volume: 45, Issue:6

    Topics: Animals; Aquaculture; Blood Glucose; Diet; Hydrocortisone; Hypoxia; Immunoglobulin M; Lactic Acid; R

2019
Physiological adaptations to repeated sprint training in hypoxia induced by voluntary hypoventilation at low lung volume.
    European journal of applied physiology, 2019, Volume: 119, Issue:9

    Topics: Adaptation, Physiological; Adult; Athletic Performance; Hemoglobins; Humans; Hypoventilation; Hypoxi

2019
Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, Mar-05, Volume: 110, Issue:10

    Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Disease Models

2013
The antioxidative effect of a novel free radical scavenger 4'-hydroxyl-2-substituted phenylnitronyl nitroxide in acute high-altitude hypoxia mice.
    Biological & pharmaceutical bulletin, 2013, Volume: 36, Issue:6

    Topics: Altitude; Altitude Sickness; Animals; Antioxidants; Catalase; Cyclic N-Oxides; Glutathione Peroxidas

2013
Effects of fatty acid provision during severe hypoxia on routine and maximal performance of the in situ tilapia heart.
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2013, Volume: 183, Issue:6

    Topics: Animals; Cardiac Output; Fatty Acids, Nonesterified; Female; Heart; Heart Rate; Hypoxia; In Vitro Te

2013
Bile benzo[a]pyrene concentration and hepatic CYP1A induction in hypoxic adult tilapia (Oreochromis niloticus).
    Chemosphere, 2013, Volume: 92, Issue:1

    Topics: Animals; Benzo(a)pyrene; Bile; Blood Glucose; Cytochrome P-450 CYP1A1; Hematocrit; Hypoxia; L-Lactat

2013
The effects of exercise under hypoxia on cognitive function.
    PloS one, 2013, Volume: 8, Issue:5

    Topics: Adult; Body Temperature; Brain; Cognition; Exercise; Heart Rate; Hemoglobins; Humans; Hypoxia; Lacti

2013
Early detection of gut ischemia-reperfusion injury during aortic abdominal aneurysmectomy: a pilot, observational study.
    Journal of cardiothoracic and vascular anesthesia, 2013, Volume: 27, Issue:4

    Topics: Aged; Aneurysm, Ruptured; Aortic Aneurysm, Abdominal; Carbon Dioxide; Colon; Constriction; Female; H

2013
Differences of glycolysis in skeletal muscle and lactate metabolism in liver between plateau zokor (Myospalax baileyi) and plateau pika (Ochotona curzoniae).
    Sheng li xue bao : [Acta physiologica Sinica], 2013, Jun-25, Volume: 65, Issue:3

    Topics: Animals; Glycolysis; Hypoxia; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Lactic A

2013
Acute physiological and performance responses to repeated sprints in varying degrees of hypoxia.
    Journal of science and medicine in sport, 2014, Volume: 17, Issue:4

    Topics: Adult; Athletic Performance; Electromyography; Fatigue; Heart Rate; Humans; Hypoxia; Lactic Acid; Ma

2014
Low-dose vasopressin improves cardiac function in newborn piglets with acute hypoxia-reoxygenation.
    Shock (Augusta, Ga.), 2013, Volume: 40, Issue:4

    Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Cardiac Output; Dobutamine; Glutathione; Heart Ventr

2013
Acidic lactate sequentially induced lymphogenesis, phlebogenesis, and arteriogenesis (ALPHA) hypothesis: Lactate-triggered glycolytic vasculogenesis that occurs in normoxia or hypoxia and complements the traditional concept of hypoxia-based vasculogenesis
    Surgery, 2013, Volume: 154, Issue:3

    Topics: Fibroblast Growth Factor 2; Glycolysis; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit;

2013
Association between a geriatric trauma resuscitation protocol using venous lactate measurements and early trauma surgeon involvement and mortality risk.
    Journal of the American Geriatrics Society, 2013, Volume: 61, Issue:8

    Topics: Aged, 80 and over; Colorado; Cooperative Behavior; Early Medical Intervention; Female; Geriatric Ass

2013
Nodal regulates energy metabolism in glioma cells by inducing expression of hypoxia-inducible factor 1α.
    Neuro-oncology, 2013, Volume: 15, Issue:10

    Topics: Adenosine Triphosphate; Blotting, Western; Brain Neoplasms; Energy Metabolism; Glioma; Glucose; Glyc

2013
Acid-base patterns in acute severe asthma.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 2013, Volume: 50, Issue:10

    Topics: Acidosis, Respiratory; Acute Disease; Adult; Aged; Aged, 80 and over; Alkalosis, Respiratory; Asthma

2013
Effects of post-resuscitation administration with sodium hydrosulfide on cardiac recovery in hypoxia-reoxygenated newborn piglets.
    European journal of pharmacology, 2013, Oct-15, Volume: 718, Issue:1-3

    Topics: Animals; Animals, Newborn; Asphyxia; Biological Transport; Blood Gas Analysis; Female; Glutathione;

2013
Stability of cerebral metabolism and substrate availability in humans during hypoxia and hyperoxia.
    Clinical science (London, England : 1979), 2014, Volume: 126, Issue:9

    Topics: Adult; Analysis of Variance; Blood Flow Velocity; Blood Glucose; Brain; Carbohydrate Metabolism; Car

2014
Tissue-type plasminogen activator mediates neuroglial coupling in the central nervous system.
    Neuroscience, 2014, Jan-17, Volume: 257

    Topics: AMP-Activated Protein Kinases; Animals; Animals, Newborn; Arabinose; Cell Death; Cells, Cultured; Ce

2014
JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Jan-07, Volume: 111, Issue:1

    Topics: Active Transport, Cell Nucleus; Allosteric Site; Breast Neoplasms; Carrier Proteins; Cell Line, Tumo

2014
High altitude may alter oxygen availability and renal metabolism in diabetics as measured by hyperpolarized [1-(13)C]pyruvate magnetic resonance imaging.
    Kidney international, 2014, Volume: 86, Issue:1

    Topics: Alanine; Altitude; Altitude Sickness; Animals; Atmospheric Pressure; Bicarbonates; Blood Glucose; Di

2014
The gene expression profile of inflammatory, hypoxic and metabolic genes predicts the metastatic spread of human head and neck squamous cell carcinoma.
    Oral oncology, 2014, Volume: 50, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Carcinoma, Squamous Cell; Extracellular Matrix; Femal

2014
Effects of exercise training on indicators of adipose tissue angiogenesis and hypoxia in obese rats.
    Metabolism: clinical and experimental, 2014, Volume: 63, Issue:4

    Topics: Adipose Tissue; Animals; Biomarkers; Hypoxia; Lactic Acid; Male; Neovascularization, Pathologic; Obe

2014
Resting arterial oxygen saturation and breathing frequency as predictors for acute mountain sickness development: a prospective cohort study.
    Sleep & breathing = Schlaf & Atmung, 2014, Volume: 18, Issue:3

    Topics: Acute Disease; Adult; Altitude Sickness; Atmosphere Exposure Chambers; Cohort Studies; Disease Susce

2014
M(o)TOR of pseudo-hypoxic state in aging: rapamycin to the rescue.
    Cell cycle (Georgetown, Tex.), 2014, Volume: 13, Issue:4

    Topics: Aging; Animals; Antibiotics, Antineoplastic; Cell Hypoxia; Cell Line; Cell Proliferation; Cellular S

2014
Rapid uptake of glucose and lactate, and not hypoxia, induces apoptosis in three-dimensional tumor tissue culture.
    Integrative biology : quantitative biosciences from nano to macro, 2014, Volume: 6, Issue:4

    Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Gas Chromatography-Mass Spectrometry;

2014
Acute regulation of hematocrit and acid-base balance in chicken embryos in response to severe intrinsic hypercapnic hypoxia.
    Respiratory physiology & neurobiology, 2014, May-01, Volume: 195

    Topics: Acid-Base Equilibrium; Acid-Base Imbalance; Animals; Chick Embryo; Erythrocyte Indices; Erythrocytes

2014
Prolonged hypoxia increases survival even in Zebrafish (Danio rerio) showing cardiac arrhythmia.
    PloS one, 2014, Volume: 9, Issue:2

    Topics: Animals; Arrhythmias, Cardiac; Blotting, Western; Energy Metabolism; Hypoxia; Lactic Acid; Larva; Mi

2014
Riboflavin supplementation improves energy metabolism in mice exposed to acute hypoxia.
    Physiological research, 2014, Volume: 63, Issue:3

    Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Carnitine; Dietary Supplements; Drug Evaluation, Prec

2014
Greater performance impairment of black runners than white runners when running in hypoxia.
    International journal of sports medicine, 2014, Volume: 35, Issue:10

    Topics: Adult; Anthropometry; Black People; Exercise Test; Fatigue; Heart Rate; Humans; Hypoxia; Lactic Acid

2014
Effect of temperature on hypoxia tolerance and its underlying biochemical mechanism in two juvenile cyprinids exhibiting distinct hypoxia sensitivities.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2015, Volume: 187

    Topics: Adaptation, Physiological; Animals; Brain; Cyprinidae; Glucose; Glycogen; Hypoxia; Lactic Acid; Live

2015
Dichloroacetate selectively improves cardiac function and metabolism in female and male rainbow trout.
    American journal of physiology. Heart and circulatory physiology, 2014, Nov-15, Volume: 307, Issue:10

    Topics: Animals; Calcium; Cardiac Pacing, Artificial; Citric Acid; Dichloroacetic Acid; Energy Metabolism; E

2014
The combined effect of hypoxia and nutritional status on metabolic and ionoregulatory responses of common carp (Cyprinus carpio).
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2015, Volume: 179

    Topics: Ammonia; Animals; Carps; Energy Metabolism; Fasting; Feeding Behavior; Gills; Glycogen; Hypoxia; Ion

2015
Interstitial lactate, lactate/pyruvate and glucose in rat muscle before, during and in the recovery from global hypoxia.
    Acta veterinaria Scandinavica, 2014, Nov-13, Volume: 56

    Topics: Animals; Energy Metabolism; Glucose; Hypoxia; Lactic Acid; Male; Microdialysis; Muscle, Skeletal; Py

2014
Exercise effects on erythrocyte deformability in exercise-induced arterial hypoxemia.
    International journal of sports medicine, 2015, Volume: 36, Issue:4

    Topics: Adult; Erythrocyte Deformability; Erythrocyte Indices; Erythrocytes; Exercise; Hemoglobinometry; Hum

2015
Anoxia-induced changes in optimal substrate for peripheral nerve.
    Neuroscience, 2015, Jan-22, Volume: 284

    Topics: 3-Hydroxybutyric Acid; Acetates; Action Potentials; Animals; Fructose; Galactose; Glucose; Hypoxia;

2015
Does moderate hypoxia alter working memory and executive function during prolonged exercise?
    Physiology & behavior, 2015, Volume: 139

    Topics: Bicycling; Executive Function; Exercise; Heart Rate; Humans; Hypoxia; Lactic Acid; Male; Memory, Sho

2015
Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells.
    Experimental cell research, 2015, Feb-01, Volume: 331, Issue:1

    Topics: Blotting, Western; Cell Proliferation; Colorectal Neoplasms; Dichloroacetic Acid; Flow Cytometry; Gl

2015
Hypoxia enhances antitumor activity of dichloroacetate.
    Experimental oncology, 2014, Volume: 36, Issue:4

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell

2014
Elite female athletes' ventilatory compensation to decreased inspired O2 during the wingate test.
    Research quarterly for exercise and sport, 2015, Volume: 86, Issue:2

    Topics: Adenosine Triphosphate; Adolescent; Energy Metabolism; Fatigue; Female; Humans; Hypoxia; Lactic Acid

2015
The characteristics and correlation between the ischemia-reperfusion and changes of redox status in the early stage of severe burns.
    The American journal of emergency medicine, 2015, Volume: 33, Issue:3

    Topics: Adult; Burns; Case-Control Studies; Cohort Studies; Disease Progression; Hematocrit; Humans; Hypoxia

2015
Day-to-day variability in cardiorespiratory responses to hypoxic cycle exercise.
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2015, Volume: 40, Issue:2

    Topics: Adult; Analysis of Variance; Bicycling; Carbon Dioxide; Exercise; Heart Rate; Humans; Hypoxia; Lacti

2015
Platinum-doped ceria based biosensor for in vitro and in vivo monitoring of lactate during hypoxia.
    Analytical chemistry, 2015, Mar-03, Volume: 87, Issue:5

    Topics: Animals; Biosensing Techniques; Brain; Cerium; Electrochemistry; Enzymes, Immobilized; Hippocampus;

2015
Decrease in circulating plasmacytoid dendritic cells during short-term systemic normobaric hypoxia.
    European journal of clinical investigation, 2016, Volume: 46, Issue:2

    Topics: Adult; Altitude; Atmospheric Pressure; Cell Count; Dendritic Cells; Female; Flow Cytometry; Healthy

2016
PLGA/poloxamer nanoparticles loaded with EPAS1 siRNA for the treatment of pancreatic cancer in vitro and in vivo.
    International journal of molecular medicine, 2015, Volume: 35, Issue:4

    Topics: Animals; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cell Proliferati

2015
Cerebral water and ion balance remains stable when humans are exposed to acute hypoxic exercise.
    High altitude medicine & biology, 2015, Volume: 16, Issue:1

    Topics: Acid-Base Equilibrium; Adult; Altitude Sickness; Body Water; Brain; Brain Chemistry; Brain Edema; Ex

2015
Measurement of the acute metabolic response to hypoxia in rat tumours in vivo using magnetic resonance spectroscopy and hyperpolarised pyruvate.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2015, Volume: 116, Issue:3

    Topics: Animals; Carbon Isotopes; Disease Models, Animal; Fibrosarcoma; Hypoxia; Lactic Acid; Magnetic Reson

2015
Hypoxia decreases glucagon-like peptide-1 secretion from the GLUTag cell line.
    Biological & pharmaceutical bulletin, 2015, Volume: 38, Issue:4

    Topics: Adenosine Triphosphate; Animals; Cell Line; Colforsin; Colon; Cyclic AMP Response Element-Binding Pr

2015
64Cu-CTS: A Promising Radiopharmaceutical for the Identification of Low-Grade Cardiac Hypoxia by PET.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2015, Volume: 56, Issue:6

    Topics: Adenosine Triphosphate; Animals; Coordination Complexes; Copper Radioisotopes; Creatine Kinase; Hear

2015
A lactate-induced response to hypoxia.
    Cell, 2015, Apr-23, Volume: 161, Issue:3

    Topics: Cell Hypoxia; Cell Line; Gene Expression Regulation; Humans; Hypoxia; Hypoxia-Inducible Factor-Proli

2015
NDRG3-mediated lactate signaling in hypoxia.
    BMB reports, 2015, Volume: 48, Issue:6

    Topics: Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxyge

2015
[The expression of the sperm-specific lactate dehydrogenase gene Ldh-c in plateau pika (Ochotona curzoniae) cardiac muscle and its effect on the anaerobic glycolysis].
    Sheng li xue bao : [Acta physiologica Sinica], 2015, Jun-25, Volume: 67, Issue:3

    Topics: Acclimatization; Animals; Glycolysis; Hypoxia; Isoenzymes; L-Lactate Dehydrogenase; Lactic Acid; Lag

2015
Chronic stress of rainbow trout Oncorhynchus mykiss at high altitude: a field study.
    Journal of fish biology, 2015, Volume: 87, Issue:1

    Topics: Altitude; Animals; Antioxidants; Blood Glucose; Hemoglobins; Hydrocortisone; Hypoxia; Lactic Acid; M

2015
Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Aug-18, Volume: 112, Issue:33

    Topics: Acclimatization; Altitude; Animals; Atrial Natriuretic Factor; Cardiac Output; Ethiopia; Female; Hea

2015
What limits performance during whole-body incremental exercise to exhaustion in humans?
    The Journal of physiology, 2015, Oct-15, Volume: 593, Issue:20

    Topics: Adenosine Triphosphate; Adult; Exercise; Exercise Test; Fatigue; Humans; Hydrogen-Ion Concentration;

2015
Anti-hypoxia Activity of the Novel NO Donor Acetyl Ferulic Isosorbide Mononitrate in Acute High-Altitude Hypoxia Mice.
    Biological & pharmaceutical bulletin, 2015, Volume: 38, Issue:9

    Topics: Adenosine Triphosphate; Altitude Sickness; Animals; Blood Pressure; Catalase; Cerebrum; Glutathione

2015
Elevated serum uric acid after injury correlates with the early acute kidney in severe burns.
    Burns : journal of the International Society for Burn Injuries, 2015, Volume: 41, Issue:8

    Topics: Acute Kidney Injury; Adult; APACHE; Body Surface Area; Burns; C-Reactive Protein; Cohort Studies; Cr

2015
Oxygen regulation of breathing through an olfactory receptor activated by lactate.
    Nature, 2015, Nov-12, Volume: 527, Issue:7577

    Topics: Animals; Calcium Signaling; Carotid Body; Carotid Sinus; Female; HEK293 Cells; Humans; Hypercapnia;

2015
Phenotypic plasticity in the common snapping turtle (Chelydra serpentina): long-term physiological effects of chronic hypoxia during embryonic development.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2016, Jan-15, Volume: 310, Issue:2

    Topics: Adaptation, Physiological; Age Factors; Animals; Arterial Pressure; Biomarkers; Blood Glucose; Body

2016
REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia.
    Scientific reports, 2015, Dec-09, Volume: 5

    Topics: Base Sequence; Binding Sites; Computational Biology; Gene Expression Regulation; Glucose; Glycolysis

2015
Acute hypoxia increases the cerebral metabolic rate - a magnetic resonance imaging study.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2016, Volume: 36, Issue:6

    Topics: Adolescent; Adult; Brain; Cerebrovascular Circulation; Creatine; Energy Metabolism; Glutamic Acid; H

2016
XBP1 silencing decreases glioma cell viability and glycolysis possibly by inhibiting HK2 expression.
    Journal of neuro-oncology, 2016, Volume: 126, Issue:3

    Topics: Adenosine Triphosphate; Animals; Apoptosis; Cell Proliferation; DNA-Binding Proteins; Female; Gene S

2016
Nitric oxide availability in deeply hypoxic crucian carp: acute and chronic changes and utilization of ambient nitrite reservoirs.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2016, Mar-15, Volume: 310, Issue:6

    Topics: Adenosine Triphosphate; Animals; Carps; Female; Gills; Hypoxia; Lactic Acid; Male; Nitric Oxide; Nit

2016
Dysregulated bioenergetics: a key regulator of joint inflammation.
    Annals of the rheumatic diseases, 2016, Volume: 75, Issue:12

    Topics: Amino Acids, Dicarboxylic; Arthritis, Rheumatoid; Cell Movement; Cells, Cultured; Cytokines; DNA, Mi

2016
A comparison of constant acceleration swimming speeds when acceleration rates are different with critical swimming speeds in Chinese bream under two oxygen tensions.
    Fish physiology and biochemistry, 2016, Volume: 42, Issue:5

    Topics: Acceleration; Animals; Cyprinidae; Glucose; Glycogen; Hypoxia; Lactic Acid; Liver; Muscles; Oxygen;

2016
Glycogen dynamics of crucian carp (Carassius carassius) in prolonged anoxia.
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2016, Volume: 186, Issue:8

    Topics: Acclimatization; Acetates; Ammonia; Animals; Body Weight; Brain; Carps; Ethanol; Gills; Glycogen; He

2016
Severe hypoxemia induced by prolonged expiration and reduced frequency breathing during submaximal swimming.
    Journal of sports sciences, 2017, Volume: 35, Issue:11

    Topics: Bicarbonates; Breath Holding; Carbon Dioxide; Heart Rate; Humans; Hydrogen-Ion Concentration; Hypoxi

2017
Effect of Hypoxia on Ldh-c Expression in Somatic Cells of Plateau Pika.
    International journal of environmental research and public health, 2016, 08-01, Volume: 13, Issue:8

    Topics: Acclimatization; Adaptation, Physiological; Altitude; Animals; Blotting, Western; Brain; Glycolysis;

2016
Selective accumulation of biotin in arterial chemoreceptors: requirement for carotid body exocytotic dopamine secretion.
    The Journal of physiology, 2016, 12-15, Volume: 594, Issue:24

    Topics: Adenosine Triphosphate; Adrenal Medulla; Animals; Arteries; Biotin; Carotid Body; Chromaffin Cells;

2016
Hypoxia-responsive miR-210 promotes self-renewal capacity of colon tumor-initiating cells by repressing ISCU and by inducing lactate production.
    Oncotarget, 2016, Oct-04, Volume: 7, Issue:40

    Topics: Aged; Aged, 80 and over; Carcinogenesis; Cell Self Renewal; Colon; Colonic Neoplasms; Colorectal Neo

2016
Evaluation of the protective effect of thiamine pyrophosphate based on the biochemical analysis of rabbit foetuses at 30 days of gestation.
    Reproductive toxicology (Elmsford, N.Y.), 2016, Volume: 65

    Topics: Animals; Blood Glucose; Calcium; Female; Fetus; Hydrogen-Ion Concentration; Hypoxia; Ischemia; Lacti

2016
Acute Physiological Responses to Moderate-Load Resistance Exercise in Hypoxia.
    Journal of strength and conditioning research, 2017, Volume: 31, Issue:7

    Topics: Adult; Electromyography; Heart Rate; Humans; Hypoxia; Lactic Acid; Male; Oxygen; Resistance Training

2017
Hypoxia induces glucose uptake and metabolism of adipose‑derived stem cells.
    Molecular medicine reports, 2016, Volume: 14, Issue:5

    Topics: Adipose Tissue; Female; Gene Expression Regulation, Enzymologic; Glucose; Glucose Transport Proteins

2016
Neurochemical changes following combined hypoxemia and hemorrhagic shock in a rat model of penetrating ballistic-like brain injury: A microdialysis study.
    The journal of trauma and acute care surgery, 2016, Volume: 81, Issue:5

    Topics: Animals; Brain; Disease Models, Animal; Glucose; Head Injuries, Penetrating; Hypoxia; Lactic Acid; M

2016
cGMP-Phosphodiesterase Inhibition Prevents Hypoxia-Induced Cell Death Activation in Porcine Retinal Explants.
    PloS one, 2016, Volume: 11, Issue:11

    Topics: Animals; Antioxidants; Caspase 3; Cell Death; Cyclic GMP; Gene Expression Regulation; Hypoxia; Hypox

2016
Reasons for death in patients with sepsis and septic shock.
    Journal of critical care, 2017, Volume: 38

    Topics: Aged; Aged, 80 and over; Cause of Death; Cohort Studies; Consensus; Death, Sudden, Cardiac; Female;

2017
Sirtuin 6 attenuates periapical lesion propagation by modulating hypoxia-induced chemokine (C-C motif) ligand 2 production in osteoblasts.
    International endodontic journal, 2018, Volume: 51 Suppl 2

    Topics: Animals; Blotting, Western; Cells, Cultured; Chemokine CCL2; Hypoxia; Lactic Acid; Mice; Mitochondri

2018
pH, Lactate, and Hypoxia: Reciprocity in Regulating High-Affinity Monocarboxylate Transporter Expression in Glioblastoma.
    Neoplasia (New York, N.Y.), 2017, Volume: 19, Issue:2

    Topics: Astrocytes; Cell Hypoxia; Cell Line, Tumor; Cells, Cultured; Gene Expression; Gene Expression Regula

2017
Prognostic value of plasma lactate levels in a retrospective cohort presenting at a university hospital emergency department.
    BMJ open, 2017, 01-30, Volume: 7, Issue:1

    Topics: Aged; Aged, 80 and over; Comorbidity; Diabetes Mellitus; Emergency Service, Hospital; Female; Hospit

2017
Metabolic origins of spatial organization in the tumor microenvironment.
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 03-14, Volume: 114, Issue:11

    Topics: Cell Line, Tumor; Cluster Analysis; Energy Metabolism; Extracellular Space; Gene Expression Profilin

2017
[Acute hypoxic hypoxia increases lactate concentration in amniotic fluid of rabbits on 27-28th day of pregnancy].
    Biomeditsinskaia khimiia, 2017, Volume: 63, Issue:1

    Topics: Amniotic Fluid; Animals; Creatinine; Female; Fetus; Hypoxia; Lactic Acid; Oxygen; Placenta; Pregnanc

2017
White sturgeon (Acipenser transmontanus) acid-base regulation differs in response to different types of acidoses.
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2017, Volume: 187, Issue:7

    Topics: Acid-Base Equilibrium; Acidosis, Lactic; Acidosis, Respiratory; Animals; Brain; Carbon Dioxide; Chlo

2017
Morphofunctional responses to anaemia in rat skeletal muscle.
    Journal of anatomy, 2008, Volume: 212, Issue:6

    Topics: Adenosine Triphosphate; Anemia; Animals; Capillaries; Creatine; Histocytochemistry; Hypoxia; Lactic

2008
PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer.
    British journal of cancer, 2008, Jun-17, Volume: 98, Issue:12

    Topics: Base Sequence; Carcinoma, Squamous Cell; Cell Line, Tumor; DNA Primers; Gene Silencing; Head and Nec

2008
Respiratory responses to progressive hypoxia in the Amazonian oscar, Astronotus ocellatus.
    Respiratory physiology & neurobiology, 2008, Jul-31, Volume: 162, Issue:2

    Topics: Adaptation, Physiological; Anaerobic Threshold; Animals; Cell Respiration; Cichlids; Energy Metaboli

2008
[Levels of lactic acid].
    Revue de l'infirmiere, 2008, Issue:140

    Topics: Acidosis, Lactic; Arteries; Blood Specimen Collection; Causality; Drug Interactions; Humans; Hypoxia

2008
Effects of hypoxia on relationships between cytosolic and mitochondrial NAD(P)H redox and superoxide generation in coronary arterial smooth muscle.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:3

    Topics: Animals; Cattle; Coronary Vessels; Cytosol; Fluorescent Dyes; Hypoxia; In Vitro Techniques; Lactic A

2008
Effects of continuous hypoxia on energy metabolism in cultured cerebro-cortical neurons.
    Brain research, 2008, Sep-10, Volume: 1229

    Topics: Animals; Carbon Isotopes; Cells, Cultured; Cerebellum; Cerebral Cortex; Citrate (si)-Synthase; Embry

2008
Effects of acute intermittent hypercapnic hypoxia on insulin sensitivity in piglets using euglycemic clamp.
    Metabolism: clinical and experimental, 2008, Volume: 57, Issue:8

    Topics: Animals; Animals, Newborn; Blood Gas Analysis; Blood Glucose; Blood Pressure; Glucose Clamp Techniqu

2008
Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction.
    Pediatric research, 2009, Volume: 65, Issue:1

    Topics: Acidosis; Amino Acids; Animals; Blood Glucose; Carbon Dioxide; Disease Models, Animal; Down-Regulati

2009
Thermoregulatory and metabolic responses of Japanese quail to hypoxia.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2008, Volume: 151, Issue:4

    Topics: Acclimatization; Animals; Body Temperature Regulation; Chronic Disease; Coturnix; Hypercapnia; Hypox

2008
Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis.
    Arthritis and rheumatism, 2008, Volume: 58, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Animals; Arthritis; Arthritis, Experimental; Blotting, Western; Cell

2008
Pathophysiology of critical ill patients: focus on critical oxygen delivery.
    Acta medica Indonesiana, 2008, Volume: 40, Issue:3

    Topics: Acute Disease; Adenosine Triphosphate; Cardiac Output; Cell Hypoxia; Critical Illness; Humans; Hypox

2008
Differential recovery from exercise and hypoxia exposure measured using 31P- and 1H-NMR in white muscle of the common carp Cyprinus carpio.
    The Journal of experimental biology, 2008, Volume: 211, Issue:Pt 20

    Topics: Acclimatization; Adenosine Triphosphate; Animals; Carps; Hydrogen; Hypoxia; Lactic Acid; Magnetic Re

2008
About the lactic acid exchange between arterial blood and brain tissue and its changes in lack of oxygen.
    Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere, 1948, Volume: 249, Issue:6-7

    Topics: Blood; Brain; Humans; Hypoxia; Lactic Acid; Oxygen; Tissues

1948
On the blood lactic acid response to measured exercise in hypoxic human subjects.
    The Journal of clinical investigation, 1948, Volume: 27, Issue:2

    Topics: Blood; Exercise; Humans; Hypoxia; Lactic Acid; Oxygen

1948
Blood lactate and oxygen debt after exhaustive work at different oxygen tensions.
    Acta physiologica Scandinavica, 1948, Feb-28, Volume: 15, Issue:1

    Topics: Blood; Blood Gas Analysis; Humans; Hypoxia; Lactic Acid; Oxygen; Oxygen Consumption; Work

1948
The genomic analysis of lactic acidosis and acidosis response in human cancers.
    PLoS genetics, 2008, Volume: 4, Issue:12

    Topics: Acidosis; Breast Neoplasms; Cells, Cultured; Energy Metabolism; Female; Gene Expression Profiling; G

2008
Arterial blood gases and oxygen content in climbers on Mount Everest.
    The New England journal of medicine, 2009, Jan-08, Volume: 360, Issue:2

    Topics: Adult; Altitude; Arteries; Atmospheric Pressure; Blood Gas Analysis; Carbon Dioxide; Female; Hemoglo

2009
[The role of hypoxic syndrome in pathogenesis of experimental stress-lesions].
    Klinichna khirurhiia, 2008, Issue:8

    Topics: Animals; Biomarkers; Disease Models, Animal; Hypoxia; Lactic Acid; Male; Oxygen; Pain; Pain Manageme

2008
Commentaries on viewpoint: evidence that reduced skeletal muscle recruitment explains the lactate paradox during exercise at high altitude.
    Journal of applied physiology (Bethesda, Md. : 1985), 2009, Volume: 106, Issue:2

    Topics: Acclimatization; Altitude; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lactic Acid; Models, Ne

2009
Last word on viewpoint: evidence that reduced skeletal muscle recruitment explains the lactate paradox during exercise at high altitude.
    Journal of applied physiology (Bethesda, Md. : 1985), 2009, Volume: 106, Issue:2

    Topics: Acclimatization; Altitude; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lactic Acid; Models, Ne

2009
Influence of performance level on exercise-induced arterial hypoxemia during prolonged and successive exercise in triathletes.
    International journal of sports physiology and performance, 2008, Volume: 3, Issue:4

    Topics: Adult; Bicycling; Blood Gas Analysis; Humans; Hypoxia; Lactic Acid; Male; Oximetry; Oxygen Consumpti

2008
Reduced skeletal muscle recruitment does not explain the lactate paradox - part I.
    Journal of applied physiology (Bethesda, Md. : 1985), 2009, Volume: 106, Issue:2

    Topics: Acclimatization; Altitude; Brain; Cardiac Output; Exercise; Heart Rate; Humans; Hypoxia; Lactic Acid

2009
Origin of the lactate paradox: muscles or brain?
    Journal of applied physiology (Bethesda, Md. : 1985), 2009, Volume: 106, Issue:2

    Topics: Acclimatization; Altitude; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lactic Acid; Models, Ne

2009
Reduced skeletal muscle recruitment does not explain the lactate paradox.
    Journal of applied physiology (Bethesda, Md. : 1985), 2009, Volume: 106, Issue:2

    Topics: Acclimatization; Altitude; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lactic Acid; Models, Ne

2009
Commentaries on viewpoint: evidence that reduced skeletal muscle recruitment explains the lactate paradox during exercise at high altitude.
    Journal of applied physiology (Bethesda, Md. : 1985), 2009, Volume: 106, Issue:2

    Topics: Acclimatization; Altitude; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lactic Acid; Models, Ne

2009
Blood lactate at high altitude: central command but also mass effect and andrenergic drive.
    Journal of applied physiology (Bethesda, Md. : 1985), 2009, Volume: 106, Issue:2

    Topics: Acclimatization; Adrenergic Fibers; Altitude; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lact

2009
Reduced skeletal muscle recruitment does not explain the lactate paradox- part II.
    Journal of applied physiology (Bethesda, Md. : 1985), 2009, Volume: 106, Issue:2

    Topics: Acclimatization; Altitude; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lactic Acid; Models, Ne

2009
Commentaries on viewpoint: evidence that reduced skeletal muscle recruitment explains the lactate paradox during exercise at high altitude.
    Journal of applied physiology (Bethesda, Md. : 1985), 2009, Volume: 106, Issue:2

    Topics: Acclimatization; Altitude; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lactic Acid; Models, Ne

2009
Origin of the lactate paradox:muscles or brain? Part II.
    Journal of applied physiology (Bethesda, Md. : 1985), 2009, Volume: 106, Issue:2

    Topics: Acclimatization; Altitude; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lactic Acid; Models, Ne

2009
Cerebral control of skeletal muscle recruitment during exercise at altitude.
    Journal of applied physiology (Bethesda, Md. : 1985), 2009, Volume: 106, Issue:2

    Topics: Acclimatization; Altitude; Brain; Cardiac Output; Cerebrovascular Circulation; Exercise; Humans; Hyp

2009
It takes a brain.
    Journal of applied physiology (Bethesda, Md. : 1985), 2009, Volume: 106, Issue:2

    Topics: Acclimatization; Altitude; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lactic Acid; Models, Ne

2009
Commentaries on viewpoint: evidence that reduced skeletal muscle recruitment explains the lactate paradox during exercise at high altitude.
    Journal of applied physiology (Bethesda, Md. : 1985), 2009, Volume: 106, Issue:2

    Topics: Acclimatization; Altitude; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lactic Acid; Models, Ne

2009
Mechanism of action of Rhodiola imbricata Edgew during exposure to cold, hypoxia and restraint (C-H-R) stress induced hypothermia and post stress recovery in rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2009, Volume: 47, Issue:6

    Topics: Animals; Blood Glucose; Cold Temperature; Energy Metabolism; Fatty Acids, Nonesterified; Glycogen; G

2009
Exercise- and hypoxia-induced anaerobic metabolism and recovery: a student laboratory exercise using teleost fish.
    Advances in physiology education, 2009, Volume: 33, Issue:1

    Topics: Anaerobic Threshold; Animals; Fundulidae; Humans; Hypoxia; Lactic Acid; Models, Animal; Models, Biol

2009
Nitric oxide increases myocardial efficiency in the hypoxia-tolerant turtle Trachemys scripta.
    The Journal of experimental biology, 2009, Volume: 212, Issue:Pt 7

    Topics: Adaptation, Biological; Animals; Arginine; Heart Ventricles; Hypoxia; Lactic Acid; Microscopy, Confo

2009
Enhanced leukocyte HIF-1alpha and HIF-1 DNA binding in humans after rapid ascent to 4300 m.
    Free radical biology & medicine, 2009, Jun-01, Volume: 46, Issue:11

    Topics: Adult; Altitude; Biomarkers; Dinoprost; DNA; Female; Free Radicals; Glutathione; Heart Rate; Humans;

2009
Hematological responses of the grey carpet shark (Chiloscyllium punctatum) and the epaulette shark (Hemiscyllium ocellatum) to anoxia and re-oxygenation.
    Journal of experimental zoology. Part A, Ecological genetics and physiology, 2009, Jul-01, Volume: 311, Issue:6

    Topics: Adaptation, Physiological; Animals; Blood Glucose; Disease Models, Animal; Erythrocyte Count; Hemato

2009
Failure of hypoxia to exaggerate the metabolic stress in working muscle following short-term training.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 297, Issue:3

    Topics: Adaptation, Physiological; Adenine Nucleotides; Bicycling; Exercise; Glucose; Glycolysis; Heart Rate

2009
Muscle bioenergetics and metabolic control at altitude.
    High altitude medicine & biology, 2009,Summer, Volume: 10, Issue:2

    Topics: Adaptation, Physiological; Altitude; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lac

2009
Nocturnal hypoxia and arterial lactate levels in sleep-related breathing disorders.
    Southern medical journal, 2009, Volume: 102, Issue:7

    Topics: Adult; Arteries; Biomarkers; Blood Gas Analysis; Case-Control Studies; Female; Humans; Hypoxia; Lact

2009
A dual-emissive-materials design concept enables tumour hypoxia imaging.
    Nature materials, 2009, Volume: 8, Issue:9

    Topics: Animals; Breast Neoplasms; Disease Models, Animal; Hypoxia; Lactic Acid; Mice; Nanoparticles; Neopla

2009
Metabolic aspects of neonatal rat islet hypoxia tolerance.
    Transplant international : official journal of the European Society for Organ Transplantation, 2010, Volume: 23, Issue:1

    Topics: Adenosine Triphosphate; Aging; Animals; Animals, Newborn; Calcium; Cells, Cultured; Cyclic AMP; Gluc

2010
Fabrication and characterization of prosurvival growth factor releasing, anisotropic scaffolds for enhanced mesenchymal stem cell survival/growth and orientation.
    Biomacromolecules, 2009, Sep-14, Volume: 10, Issue:9

    Topics: Cell Culture Techniques; Cell Proliferation; Humans; Hypoxia; Insulin-Like Growth Factor I; Lactic A

2009
Systemic hypoxia affects exercise-mediated antitumor cytotoxicity of natural killer cells.
    Journal of applied physiology (Bethesda, Md. : 1985), 2009, Volume: 107, Issue:6

    Topics: Adult; Analysis of Variance; Antigens, CD; Cell Line; Cell Separation; Cells, Cultured; Cytotoxicity

2009
Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes.
    Pflugers Archiv : European journal of physiology, 2010, Volume: 459, Issue:3

    Topics: Adipocytes; Adipose Tissue; Antimutagenic Agents; Cells, Cultured; Cobalt; Female; Gene Expression R

2010
Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts.
    International journal of radiation biology, 2009, Volume: 85, Issue:11

    Topics: Animals; Benzimidazoles; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Female; Fluo

2009
Training in hypoxia fails to further enhance endurance performance and lactate clearance in well-trained men and impairs glucose metabolism during prolonged exercise.
    Experimental physiology, 2010, Volume: 95, Issue:2

    Topics: Adult; Altitude; Blood Glucose; Exercise Tolerance; Humans; Hypoxia; Lactic Acid; Male; Metabolic Cl

2010
Metabolic profiling of heat or anoxic stress in mouse C2C12 myotubes using multinuclear magnetic resonance spectroscopy.
    Metabolism: clinical and experimental, 2010, Volume: 59, Issue:6

    Topics: Adenosine Diphosphate; Amino Acids; Animals; Biomarkers; Cell Line; Data Interpretation, Statistical

2010
Effects of acute hypoxia on metabolic and hormonal responses to resistance exercise.
    Medicine and science in sports and exercise, 2010, Volume: 42, Issue:7

    Topics: Adult; Epinephrine; Exercise; Human Growth Hormone; Humans; Hydrocortisone; Hypoxia; Insulin-Like Gr

2010
Acid-base balance and ventilation during sternal and lateral recumbency in field immobilized black rhinoceros (Diceros bicornis) receiving oxygen insufflation: a preliminary report.
    Journal of wildlife diseases, 2010, Volume: 46, Issue:1

    Topics: Acid-Base Equilibrium; Animals; Animals, Wild; Azaperone; Blood Gas Analysis; Capnography; Etorphine

2010
Hypothermic protection in an acute hypoxia model in rats: Acid-base and oxidant/antioxidant profiles.
    Resuscitation, 2010, Volume: 81, Issue:5

    Topics: Acid-Base Equilibrium; Acidosis; Animals; Antioxidants; Arteries; Disease Models, Animal; Glutathion

2010
Common phenotype of resting mouse extensor digitorum longus and soleus muscles: equal ATPase and glycolytic flux during transient anoxia.
    The Journal of physiology, 2010, Jun-01, Volume: 588, Issue:Pt 11

    Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Aerobiosis; Algorithms; Animals; Biological Transp

2010
Metabolic responses of Parastacus defossus and Parastacus brasiliensis (Crustacea, Decapoda, Parastacidae) to hypoxia.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2010, Volume: 156, Issue:4

    Topics: Animals; Astacoidea; Glucose; Hemolymph; Hypoxia; Lactic Acid; Lipids; Proteins; Species Specificity

2010
Effect of moderate hypoxia at three acclimation temperatures on stress responses in Atlantic cod with different haemoglobin types.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2010, Volume: 156, Issue:4

    Topics: Acclimatization; Animals; Gadus morhua; Hemoglobins; HSP70 Heat-Shock Proteins; Hydrocortisone; Hypo

2010
Aerobic and anaerobic metabolism for the zebrafish, Danio rerio, reared under normoxic and hypoxic conditions and exposed to acute hypoxia during development.
    Brazilian journal of biology = Revista brasleira de biologia, 2010, Volume: 70, Issue:2

    Topics: Aerobiosis; Anaerobiosis; Animals; Body Mass Index; Heart Rate; Hypoxia; Lactic Acid; Oxygen Consump

2010
Regulation of human metabolism by hypoxia-inducible factor.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Jul-13, Volume: 107, Issue:28

    Topics: Adult; Exercise; Female; Gene Expression Regulation; Humans; Hypoxia; Lactates; Lactic Acid; Male; M

2010
Cardiac atria are the primary source of ANP release in hypoxia-adapted rats.
    Life sciences, 2010, Sep-11, Volume: 87, Issue:11-12

    Topics: Animals; Atrial Natriuretic Factor; Body Weight; Calcium; Glucose; Heart Atria; Hydrogen-Ion Concent

2010
[Treatment of anaemia of prematurity with SS-R-Hu-erythropoietin and significance of hypoxia-inducible factor].
    Akusherstvo i ginekologiia, 2010, Volume: 49, Issue:1

    Topics: Anemia, Neonatal; Erythrocyte Transfusion; Erythropoietin; Hematocrit; Hemoglobinometry; Humans; Hyp

2010
Nitric oxide metabolites in goldfish under normoxic and hypoxic conditions.
    The Journal of experimental biology, 2010, Nov-01, Volume: 213, Issue:Pt 21

    Topics: Animals; Erythrocytes; Gills; Goldfish; Hemoglobins; Hypoxia; Lactic Acid; Nitrates; Nitric Oxide; O

2010
Hypoxia stimulates lactate disposal in rainbow trout.
    The Journal of experimental biology, 2010, Nov-15, Volume: 213, Issue:Pt 22

    Topics: Anaerobiosis; Animals; Blood Glucose; Carbohydrate Metabolism; Carbon Radioisotopes; Female; Fish Di

2010
Two structurally different T-type Ca 2+ channel inhibitors, mibefradil and pimozide, protect CA1 neurons from delayed death after global ischemia in rats.
    Fundamental & clinical pharmacology, 2011, Volume: 25, Issue:4

    Topics: Animals; Brain; CA1 Region, Hippocampal; Calcium Channel Blockers; Calcium Channels, T-Type; Cell De

2011
Anoxic survival of the Pacific hagfish (Eptatretus stoutii).
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2011, Volume: 181, Issue:3

    Topics: Adenosine Triphosphate; Animals; Basal Metabolism; Glucose; Glycogen; Hagfishes; Hypoxia; Lactic Aci

2011
The influence of glucose concentration and hypoxia on VEGF secretion by cultured retinal cells.
    Current eye research, 2011, Volume: 36, Issue:2

    Topics: Animals; Cattle; Cells, Cultured; Endothelium, Vascular; Glucose; Humans; Hypoxia; Lactic Acid; Pyru

2011
Effects of fasting on hypoxic ventilatory responses and the contribution of histamine H1 receptors in mice.
    The journal of physiological sciences : JPS, 2011, Volume: 61, Issue:2

    Topics: Animals; Basal Metabolism; Blood Glucose; Energy Metabolism; Fasting; Fatty Acids, Nonesterified; Hy

2011
[Effects of ginkgolide (Gin) on cerebral water content, Na+, K(+) -ATPase activity, MDA, lactic acid of rats during acute hypoxia condition].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2003, Volume: 19, Issue:3

    Topics: Animals; Brain; Female; Ginkgolides; Hypoxia; Lactic Acid; Male; Malondialdehyde; Rats; Rats, Spragu

2003
Anaerobic contribution during maximal anaerobic running test: correlation with maximal accumulated oxygen deficit.
    Scandinavian journal of medicine & science in sports, 2011, Volume: 21, Issue:6

    Topics: Anaerobic Threshold; Exercise Test; Humans; Hypoxia; Lactic Acid; Male; Oxygen; Oxygen Consumption;

2011
Measurements of lactate in exhaled breath condensate at rest and after maximal exercise in young and healthy subjects.
    Journal of breath research, 2010, Volume: 4, Issue:1

    Topics: Adult; Breath Tests; Exercise; Female; Humans; Hypoxia; Lactic Acid; Male; Oxygen Consumption; Young

2010
The effects of temperature on the physiological response to low oxygen in Atlantic sturgeon.
    Fish physiology and biochemistry, 2011, Volume: 37, Issue:4

    Topics: Acclimatization; Animals; Blood Glucose; Chlorides; Fishes; Hypoxia; Lactic Acid; Osmolar Concentrat

2011
Impact of short-term systemic hypoxia on phagocytosis, cytokine production, and transcription factor activation in peripheral blood cells.
    Mediators of inflammation, 2011, Volume: 2011

    Topics: Adult; Atmospheric Pressure; CD4-Positive T-Lymphocytes; Cytokines; Erythropoietin; Female; Fluoresc

2011
Shedding of the coronary endothelial glycocalyx: effects of hypoxia/reoxygenation vs ischaemia/reperfusion.
    British journal of anaesthesia, 2011, Volume: 107, Issue:5

    Topics: Adenosine; Analysis of Variance; Animals; Coronary Vessels; Endothelium, Vascular; Glycocalyx; Guine

2011
Anti-hypoxic activity at simulated high altitude was isolated in petroleum ether extract of Saussurea involucrata.
    Journal of ethnopharmacology, 2011, Oct-11, Volume: 137, Issue:3

    Topics: Adenosine Triphosphate; Alkanes; Altitude Sickness; Animals; Blood Glucose; Brain; Ca(2+) Mg(2+)-ATP

2011
Lactate and the GPR81 receptor in metabolic regulation: implications for adipose tissue function and fatty acid utilisation by muscle during exercise.
    The British journal of nutrition, 2011, Volume: 106, Issue:9

    Topics: Adipose Tissue, White; Carbohydrate Metabolism; Energy Metabolism; Exercise; Fatty Acids; Glucose; H

2011
Combined central venous oxygen saturation and lactate as markers of occult hypoperfusion and outcome following cardiac surgery.
    Journal of cardiothoracic and vascular anesthesia, 2012, Volume: 26, Issue:1

    Topics: Aged; Biomarkers; Cardiac Surgical Procedures; Catheterization, Central Venous; Female; Humans; Hypo

2012
Effect of chronic intermittent hypoxia on exercise adaptations in healthy subjects.
    Respiratory physiology & neurobiology, 2011, Dec-15, Volume: 179, Issue:2-3

    Topics: Adaptation, Physiological; Blood Pressure; Exercise; Exercise Tolerance; Female; Heart Rate; Hemodyn

2011
Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect.
    The Journal of biological chemistry, 2011, Dec-09, Volume: 286, Issue:49

    Topics: Cell Line, Tumor; Citric Acid Cycle; Fermentation; Gas Chromatography-Mass Spectrometry; Glucose; Gl

2011
Maximal accumulated oxygen deficit in running and cycling.
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2011, Volume: 36, Issue:6

    Topics: Adult; Bicycling; Exercise Test; Exercise Tolerance; Female; Humans; Hypoxia; Lactic Acid; Male; Mus

2011
FTY720-loaded poly(DL-lactide-co-glycolide) electrospun scaffold significantly increases microvessel density over 7 days in streptozotocin-induced diabetic C57b16/J mice: preliminary results.
    Transplantation proceedings, 2011, Volume: 43, Issue:9

    Topics: Animals; Automation; Biocompatible Materials; Diabetes Mellitus, Experimental; Drug Delivery Systems

2011
Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment.
    Experimental cell research, 2012, Feb-15, Volume: 318, Issue:4

    Topics: Breast Neoplasms; Carcinoma; Cell Communication; Cell Line, Tumor; Female; Fibroblasts; Glycolysis;

2012
Tissue localization of nanoparticles is altered due to hypoxia resulting in poor efficacy of curcumin nanoparticles in pulmonary hypertension.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2012, Volume: 80, Issue:3

    Topics: Administration, Oral; Animals; Curcumin; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hy

2012
Changes in cardiac autonomic activity during a passive 8 hour acute exposure to 5 500 m normobaric hypoxia are not related to the development of acute mountain sickness.
    International journal of sports medicine, 2012, Volume: 33, Issue:3

    Topics: Adult; Altitude Sickness; Autonomic Nervous System; Heart Rate; Humans; Hypoxia; Lactic Acid; Male;

2012
Regulation of human monocarboxylate transporter 4 in skeletal muscle cells: the role of protein kinase C (PKC).
    International journal of pharmaceutics, 2012, May-30, Volume: 428, Issue:1-2

    Topics: Acetophenones; Base Sequence; Benzopyrans; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subuni

2012
Hypoxia and exercise provoke both lactate release and lactate oxidation by the human brain.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2012, Volume: 26, Issue:7

    Topics: Adult; Biological Transport, Active; Blood Flow Velocity; Brain; Cerebrovascular Circulation; Energy

2012
Exceptional cardiac anoxia tolerance in tilapia (Oreochromis hybrid).
    The Journal of experimental biology, 2012, Apr-15, Volume: 215, Issue:Pt 8

    Topics: Acidosis; Adaptation, Physiological; Adenosine Triphosphate; Animals; Cardiac Output; Glycolysis; He

2012
Low O2 avoidance is associated with physiological perturbation but not exhaustion in the snapper (Pagrus auratus: Sparidae).
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2012, Volume: 162, Issue:4

    Topics: Animals; Basal Metabolism; Behavior, Animal; Blood Glucose; Glycogen; Hematocrit; Hydrocortisone; Hy

2012
[Effects of acute hypobaric hypoxia and exhaustive exercise on AMP-activated protein kinase phosphorylation in rat skeletal muscle].
    Sheng li xue bao : [Acta physiologica Sinica], 2012, Apr-25, Volume: 64, Issue:2

    Topics: Altitude; AMP-Activated Protein Kinases; Animals; Computer Simulation; Glycogen; Hypoxia; Lactic Aci

2012
Lactate/pyruvate ratio as a marker of tissue hypoxia in circulatory and septic shock.
    Anaesthesia and intensive care, 2012, Volume: 40, Issue:3

    Topics: Aerobiosis; Aged; APACHE; Biomarkers; Female; Humans; Hypoxia; Lactic Acid; Male; Middle Aged; Pyruv

2012
Physiological and metabolic responses to increasing work rates: relevance for exercise prescription.
    Journal of sports sciences, 1998, Volume: 16 Suppl

    Topics: Athletic Performance; Carbohydrate Metabolism; Exercise; Fatigue; Humans; Hypoxia; Lactic Acid; Mito

1998
Role for NGF in augmented sympathetic nerve response to activation of mechanically and metabolically sensitive muscle afferents in rats with femoral artery occlusion.
    Journal of applied physiology (Bethesda, Md. : 1985), 2012, Oct-15, Volume: 113, Issue:8

    Topics: Acid Sensing Ion Channels; Animals; Arteries; Blood Pressure; Femoral Artery; Ganglia, Spinal; Hindl

2012
Infusing sodium bicarbonate suppresses hydrogen peroxide accumulation and superoxide dismutase activity in hypoxic-reoxygenated newborn piglets.
    PloS one, 2012, Volume: 7, Issue:6

    Topics: Acid-Base Equilibrium; Acidosis; Animals; Animals, Newborn; Blood Gas Analysis; Catalase; Cerebral C

2012
Red blood cell transfusion affects microdialysis-assessed interstitial lactate/pyruvate ratio in critically ill patients with late sepsis.
    Intensive care medicine, 2012, Volume: 38, Issue:11

    Topics: Adipose Tissue; Aged; Blood Specimen Collection; Erythrocyte Transfusion; Extracellular Fluid; Femal

2012
Increased oxidative stress and anaerobic energy release, but blunted Thr172-AMPKα phosphorylation, in response to sprint exercise in severe acute hypoxia in humans.
    Journal of applied physiology (Bethesda, Md. : 1985), 2012, Volume: 113, Issue:6

    Topics: Acute Disease; Adult; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Anaerobic

2012
The frontal lobe and thalamus have different sensitivities to hypoxia-hypotension after traumatic brain injury: a microdialysis study in rats.
    Journal of neurotrauma, 2012, Dec-10, Volume: 29, Issue:18

    Topics: Animals; Blood Pressure; Brain Injuries; Cerebrovascular Circulation; Energy Metabolism; Frontal Lob

2012
Hypoxaemia-induced catecholamine secretion from adrenal chromaffin cells inhibits glucose-stimulated hyperinsulinaemia in fetal sheep.
    The Journal of physiology, 2012, Nov-01, Volume: 590, Issue:21

    Topics: Adrenal Glands; Animals; Blood Glucose; Chromaffin Cells; Epinephrine; Female; Fetus; Hyperinsulinis

2012
Intraluminal intestinal microdialysis detects markers of hypoxia and cell damage in experimental necrotizing enterocolitis.
    Journal of pediatric surgery, 2012, Volume: 47, Issue:9

    Topics: Animals; Biomarkers; Colon, Sigmoid; Enterocolitis, Necrotizing; Glucose; Glycerol; Hypoxia; Ileum;

2012
Metabolic adaptations may counteract ventilatory adaptations of intermittent hypoxic exposure during submaximal exercise at altitudes up to 4000 m.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: Adaptation, Physiological; Altitude; Analysis of Variance; Baroreflex; Blood Gas Analysis; Carbon Di

2012
Temporal dynamics of lactate concentration in the human brain during acute inspiratory hypoxia.
    Journal of magnetic resonance imaging : JMRI, 2013, Volume: 37, Issue:3

    Topics: Acute Disease; Adult; Brain; Female; Humans; Hypoxia; Hypoxia, Brain; Lactates; Lactic Acid; Magneti

2013
Fetal sheep left ventricle is more sensitive than right ventricle to progressively worsening hypoxemia and acidemia.
    European journal of obstetrics, gynecology, and reproductive biology, 2013, Volume: 167, Issue:2

    Topics: Acidosis; Animals; Animals, Inbred Strains; Disease Models, Animal; Disease Progression; Female; Fin

2013
Excess post-hypoxic oxygen consumption is independent from lactate accumulation in two cyprinid fishes.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2013, Volume: 165, Issue:1

    Topics: Animals; Carps; Ethanol; Gills; Hypoxia; Lactic Acid; Muscles; Oxygen; Oxygen Consumption

2013
Developmental changes in cardiac recovery from anoxia-reoxygenation.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 283, Issue:2

    Topics: Animals; Bradycardia; Chick Embryo; Extracellular Space; Heart; Heart Block; Heart Rate; Hydrogen-Io

2002
Physiological responses to prolonged aquatic hypoxia in the Queensland lungfish Neoceratodus forsteri.
    Respiratory physiology & neurobiology, 2002, Aug-30, Volume: 132, Issue:2

    Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Erythrocytes; Fishes; Fresh Water; Hematocrit

2002
Is lactate a mediator of hypoxia-induced anapyrexia?
    Pflugers Archiv : European journal of physiology, 2002, Volume: 444, Issue:6

    Topics: Animals; Body Temperature; Body Temperature Regulation; Dichloroacetic Acid; Fever; Hypoxia; Lactic

2002
Detrimental effects of nicotine and endotoxin in the newborn piglet brain during severe hypoxemia.
    Biology of the neonate, 2002, Volume: 82, Issue:3

    Topics: Animals; Animals, Newborn; Blood Pressure; Brain Diseases; Corpus Striatum; Endotoxins; Escherichia

2002
Cytokines induce HIF-1 DNA binding and the expression of HIF-1-dependent genes in cultured rat enterocytes.
    American journal of physiology. Gastrointestinal and liver physiology, 2003, Volume: 284, Issue:3

    Topics: Animals; Blotting, Western; Cells, Cultured; Culture Media, Conditioned; Cytokines; DNA; DNA-Binding

2003
Increased skeletal muscle lactate production following hemorrhagic shock in rats.
    The Journal of trauma, 2002, Volume: 53, Issue:4

    Topics: Animals; Cell Membrane Permeability; Hypoxia; Lactic Acid; Muscle, Skeletal; Rats; Shock, Hemorrhagi

2002
Effects of fasting and hypoxic preconditioning on the hypoxic-reoxygenated ventricular strips of the rat heart.
    Journal of physiology and biochemistry, 2002, Volume: 58, Issue:2

    Topics: Acyl Coenzyme A; Analysis of Variance; Animals; Carnitine; Fasting; Heart Ventricles; Hypoxia; Ische

2002
Intraperitoneal microdialysis for detection of splanchnic metabolic disorders.
    Langenbeck's archives of surgery, 2002, Volume: 387, Issue:7-8

    Topics: Animals; Ascitic Fluid; Cryoprotective Agents; Disease Models, Animal; Extracellular Space; Gastroin

2002
[Effects of +Gx stress on contractility of rat diaphragm and its mechanism].
    Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering, 2002, Volume: 15, Issue:5

    Topics: Acceleration; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Diaph

2002
Pyruvate reverses metabolic effects produced by hypoxia in glioma and hepatoma cell cultures.
    Biochimie, 2002, Volume: 84, Issue:10

    Topics: Animals; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Glioma; Glucose; Humans; Hypoxia

2002
Comparison between the effects of chronic and acute hypoxemia on muscle afferent activities from the tibialis anterior muscle.
    Experimental brain research, 2003, Volume: 148, Issue:3

    Topics: Action Potentials; Afferent Pathways; Animals; Chronic Disease; Electric Stimulation; Evoked Potenti

2003
Preexercise hypervolemia does not affect arterial hypoxemia in Thoroughbreds performing short-term high-intensity exercise.
    Journal of applied physiology (Bethesda, Md. : 1985), 2003, Volume: 94, Issue:6

    Topics: Animal Husbandry; Animals; Arteries; Blood Proteins; Blood Volume; Body Temperature; Carbon Dioxide;

2003
Biochemical tissue monitoring during hypoxia and reoxygenation.
    Resuscitation, 2003, Volume: 56, Issue:3

    Topics: Acidosis; Animals; Blood Pressure; Hypoxia; Lactic Acid; Liver; Male; Microdialysis; Muscle, Skeleta

2003
Hindlimb glucose and lactate metabolism during umbilical cord compression and acute hypoxemia in the late-gestation ovine fetus.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2003, Volume: 284, Issue:4

    Topics: Acid-Base Equilibrium; Acute Disease; Animals; Blood Gas Analysis; Blood Glucose; Female; Femoral Ar

2003
Variability in hypoxia-induced corneal swelling is associated with variability in corneal metabolism and endothelial function.
    Eye & contact lens, 2003, Volume: 29, Issue:2

    Topics: Acidosis; Adult; Cell Count; Contact Lenses; Cornea; Corneal Edema; Endothelium, Corneal; Female; Hu

2003
Effects of the oral contraceptive pill cycle on physiological responses to hypoxic exercise.
    High altitude medicine & biology, 2003,Spring, Volume: 4, Issue:1

    Topics: Adult; Analysis of Variance; Blood Glucose; Blood Pressure; Contraceptives, Oral; Epinephrine; Exerc

2003
[Monitoring of lactate level and oxygen status for diagnosis and correction of hypoxia in critically ill patients (a lecture)].
    Klinicheskaia laboratornaia diagnostika, 2003, Issue:3

    Topics: Critical Illness; Hemostasis; Humans; Hypoxia; Lactic Acid; Monitoring, Physiologic; Oxygen

2003
The contribution of glycolytic and oxidative pathways to retinal photoreceptor function.
    Investigative ophthalmology & visual science, 2003, Volume: 44, Issue:6

    Topics: Aerobiosis; Anaerobiosis; Animals; Dark Adaptation; Drug Combinations; Electroretinography; Glucose;

2003
Orchidopexy or orchidectomy for preventing tissue hypoxia in contralateral testis following induction of ipsilateral abdominal testis associated with vas deferens obstruction.
    Urologia internationalis, 2003, Volume: 71, Issue:1

    Topics: Animals; Cryptorchidism; Hypoxanthine; Hypoxia; Lactic Acid; Male; Models, Animal; Orchiectomy; Oxid

2003
Effects of temperature and extracellular pH on metabolites: kinetics of anaerobic metabolism in resting muscle by 31P- and 1H-NMR spectroscopy.
    The Journal of experimental biology, 2003, Volume: 206, Issue:Pt 17

    Topics: Animals; Energy Metabolism; Glycolysis; Hydrogen; Hydrogen-Ion Concentration; Hypoxia; Lactic Acid;

2003
Energy cost of contraction in rat urinary bladder smooth muscle during anoxia.
    Clinical and experimental pharmacology & physiology, 2003, Volume: 30, Issue:8

    Topics: Adenosine Triphosphate; Aerobiosis; Anaerobiosis; Animals; Energy Metabolism; Hypoxia; In Vitro Tech

2003
Mapping of ATP, glucose, glycogen, and lactate concentrations within the arterial wall.
    Arteriosclerosis, thrombosis, and vascular biology, 2003, Oct-01, Volume: 23, Issue:10

    Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Carotid Arteries; Cryopreservation; Energy Me

2003
Lactate sequestration by osteoderms of the broad-nose caiman, Caiman latirostris, following capture and forced submergence.
    The Journal of experimental biology, 2003, Volume: 206, Issue:Pt 20

    Topics: Acidosis, Lactic; Alligators and Crocodiles; Analysis of Variance; Animals; Bone and Bones; Calcium;

2003
[Effect of tissue anoxia on lactic acid in blood].
    Rassegna di fisiopatologia clinica e terapeutica, 1952, Volume: 24, Issue:5

    Topics: Humans; Hypoxia; Lactic Acid

1952
Lactic acid content in human venous blood during hypoxia at high altitude.
    Acta physiologica Scandinavica, 1957, Oct-10, Volume: 40, Issue:2-3

    Topics: Altitude; Humans; Hypoxia; Lactic Acid

1957
Relationships of pyruvate and lactate during anaerobic metabolism. II. Exercise and formation of O-debt.
    The Journal of clinical investigation, 1958, Volume: 37, Issue:2

    Topics: Exercise; Hypoxia; Lactates; Lactic Acid; Metabolism; Pyruvates; Pyruvic Acid

1958
Relationships of pyruvate and lactate during anaerobic metabolism. III. Effect of breathing low-oxygen gases.
    The Journal of clinical investigation, 1958, Volume: 37, Issue:2

    Topics: Gases; Hypoxia; Lactates; Lactic Acid; Metabolism; Oxygen; Pyruvates; Pyruvic Acid

1958
Postmortem diagnosis of hypoxia by means of brain lactic acid concentration.
    The American journal of physiology, 1958, Volume: 192, Issue:3

    Topics: Brain; Hemorrhage; Humans; Hypoxia; Lactic Acid

1958
Relationship among recovery oxygen, oxygen missed, lactate production and lactate removal during and following severe hypoxia in the unanesthetized dog.
    The American journal of physiology, 1958, Volume: 192, Issue:3

    Topics: Animals; Dogs; Hypoxia; Lactates; Lactic Acid; Metabolism; Oxygen

1958
Relation of hypoxemia and/or hypocapnia to lactic acid content of brain and cardiovascular response.
    The American journal of physiology, 1958, Volume: 193, Issue:2

    Topics: Brain; Carbon Dioxide; Cardiovascular Physiological Phenomena; Cardiovascular System; Hemorrhage; Hu

1958
Lactic acid concentration of brain tissues of dogs exposed to hypoxemia and/or hypocapnia.
    Journal of applied physiology, 1958, Volume: 13, Issue:3

    Topics: Animals; Brain; Carbon Dioxide; Dogs; Hypocapnia; Hypoxia; Lactic Acid; Neurochemistry

1958
[Glucose, lactic acid, ATP and ADP concentrations in the arterial and venous coronary blood of dogs in oxygen deficiency].
    Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere, 1961, Volume: 272

    Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arteries; Blood Glucose

1961
Significance of elevated lactic acid in the postmortem brain.
    Aerospace medicine, 1960, Volume: 31

    Topics: Autopsy; Brain; Brain Chemistry; Humans; Hypoxia; Lactates; Lactic Acid

1960
Lactic acid accumulation as a cause of hypoxia-induced malformations in the chick embryo.
    Science (New York, N.Y.), 1961, Oct-27, Volume: 134, Issue:3487

    Topics: Animals; Chick Embryo; Congenital Abnormalities; Hypoxia; Lactates; Lactic Acid

1961
[Changes of serum lactic and pyruvic acid in hypoxia and hypercapnea, especially effects of respiratory changes of blood PH upon lactic acid level].
    Naika hokan. Japanese archives of internal medicine, 1962, Volume: 9

    Topics: Carbon Dioxide; Hydrogen-Ion Concentration; Hypoxia; Lactates; Lactic Acid; Pyruvates; Pyruvic Acid

1962
The inhibitory influence of lactic acid on pressor effects of sympathomimetic amines.
    Polish medical science and history bulletin, 1963, Volume: 6

    Topics: Blood Pressure; Blood Pressure Determination; Epinephrine; Hypoxia; Lactates; Lactic Acid; Norepinep

1963
Regulation of glycogenolysis in muscle. Effects of glucagon and anoxia on lactate production, glycogen content, and phosphorylase activity in the perfused isolated rat heart.
    The Journal of biological chemistry, 1963, Volume: 238

    Topics: Animals; Carbohydrate Metabolism; Glucagon; Glycogen; Glycogenolysis; Hypoxia; Lactates; Lactic Acid

1963
EXCESS LACTATE: AN INDEX OF REVERSIBILITY OF SHOCK IN HUMAN PATIENTS.
    Science (New York, N.Y.), 1964, Mar-27, Volume: 143, Issue:3613

    Topics: Animals; Blood Chemical Analysis; Dogs; Humans; Hypoxia; Lactates; Lactic Acid; Metabolism; Oxygen;

1964
EFFECT OF ANOXIA ON LACTATE/PYRUVATE AND ATP/ADP RATIOS IN ADULT AND FETAL GUINEA PIG LIVER.
    Annales paediatriae Fenniae, 1964, Volume: 10

    Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Fetus; Guinea Pigs; Hyp

1964
BLOOD LACTATE, PYRUVATE AND LACTATE-PYRUVATE RATIOS IN CONGENITAL HEART DISEASE.
    The New England journal of medicine, 1964, Jun-18, Volume: 270

    Topics: Blood Chemical Analysis; Child; Heart Defects, Congenital; Humans; Hypoxia; Lactates; Lactic Acid; N

1964
TRANSIENT ARTERIAL LACTIC ACID CHANGES IN UNANESTHETIZED DOGS AT 21,000 FEET.
    The American journal of physiology, 1964, Volume: 206

    Topics: Acclimatization; Altitude; Animals; Bicarbonates; Blood Chemical Analysis; Blood Gas Analysis; Dogs;

1964
PROLONGED ANOXIC SURVIVAL DUE TO ANOXIA PRE-EXPOSURE: BRAIN ATP, LACTATE, AND PYRUVATE.
    The American journal of physiology, 1964, Volume: 207

    Topics: Adenosine Triphosphate; Brain; Brain Chemistry; Carbohydrate Metabolism; Glucose; Glycolysis; Hypoxi

1964
THE EFFECT OF HYPOXIA ON GAS EXCHANGE AND ARTERIAL LACTATE AND PYRUVATE CONCENTRATION DURING MODERATE EXERCISE IN MAN.
    Clinical science, 1965, Volume: 28

    Topics: Arteries; Blood; Carbon Dioxide; Exercise; Humans; Hydrogen-Ion Concentration; Hyperventilation; Hyp

1965
DISTRIBUTION AND GRADIENT OF LACTATE BETWEEN BLOOD AND HEART MUSCLE.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1965, Volume: 118

    Topics: Biological Transport; Blood; Dogs; Hypoxia; Injections; Injections, Intravenous; Lactates; Lactic Ac

1965
THE ACID-BASE STATUS IN CYANOTIC CONGENITAL HEART DISEASE.
    Canadian Medical Association journal, 1965, May-22, Volume: 92

    Topics: Acid-Base Equilibrium; Acidosis; Blood Gas Analysis; Cardiac Output; Heart Defects, Congenital; Huma

1965
THE CLINICAL SIGNIFICANCE OF ELEVATED BLOOD LACTATE.
    Canadian Medical Association journal, 1965, Jun-26, Volume: 92

    Topics: Acidosis; Acidosis, Lactic; Blood; Chemical Phenomena; Chemistry; Geriatrics; Humans; Hypertension;

1965
Lactic acid in blood after various combinations of exercise and hypoxia.
    Journal of applied physiology, 1962, Volume: 17

    Topics: Dermatologic Agents; Exercise; Humans; Hypoxia; Lactates; Lactic Acid; Physical Exertion

1962
Effects of live high, train low hypoxic exposure on lactate metabolism in trained humans.
    Journal of applied physiology (Bethesda, Md. : 1985), 2004, Volume: 96, Issue:2

    Topics: Acid-Base Equilibrium; Adult; Blood Glucose; Fatty Acids, Nonesterified; Ferritins; Hematocrit; Hemo

2004
Lactate as a modulator of hypoxia-induced hyperventilation.
    Respiratory physiology & neurobiology, 2003, Oct-16, Volume: 138, Issue:1

    Topics: Acidosis, Lactic; Animals; Dichloroacetic Acid; Enzyme Inhibitors; Hyperventilation; Hypoxia; Lactic

2003
Parameters of adenylate pool as predictors of energy metabolism disturbances in hepatocytes during hypoxia.
    Bulletin of experimental biology and medicine, 2003, Volume: 136, Issue:1

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Energy Metabolism;

2003
Performance of the neonatal pig heart subjected to oxygen insufficiency.
    Biology of the neonate, 2004, Volume: 85, Issue:1

    Topics: Animals; Animals, Newborn; Aorta; Blood Pressure; Coronary Circulation; Diastole; Glucose; Glycolysi

2004
Polymers for induction of revascularization in the rat fascial flap: application of vascular endothelial growth factor and pancreatic islet cells.
    Cell transplantation, 2003, Volume: 12, Issue:7

    Topics: Animals; Cell Line; Chitin; Chitosan; Fascia; Humans; Hypoxia; Immunohistochemistry; Insulin; Islets

2003
Persistence of the lactate paradox over 8 weeks at 3,800 m.
    High altitude medicine & biology, 2003,Winter, Volume: 4, Issue:4

    Topics: Acclimatization; Adult; Altitude; Analysis of Variance; California; Epinephrine; Exercise; Exercise

2003
Lactate and glucose as energy substrates during, and after, oxygen deprivation in rat hippocampal acute and cultured slices.
    Journal of neurochemistry, 2003, Volume: 87, Issue:6

    Topics: Amino Acids; Animals; Cell Hypoxia; Cell Survival; Dose-Response Relationship, Drug; Drug Interactio

2003
Physiology of hibernation in Rana pipiens: metabolic rate, critical oxygen tension, and the effects of hypoxia on several plasma variables.
    Journal of experimental zoology. Part A, Comparative experimental biology, 2004, Feb-01, Volume: 301, Issue:2

    Topics: Analysis of Variance; Animals; Blood Glucose; Fresh Water; Hibernation; Hydrogen-Ion Concentration;

2004
Effects of acute hypoxia on the determination of anaerobic threshold using the heart rate-work rate relationships during incremental exercise tests.
    Physiological research, 2004, Volume: 53, Issue:1

    Topics: Acute Disease; Adult; Anaerobic Threshold; Carbon Dioxide; Exercise Test; Heart Rate; Humans; Hypoxi

2004
Preconditioning stimuli do not benefit the myocardium of hypoxia-tolerant rainbow trout (Oncorhynchus mykiss).
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2004, Volume: 174, Issue:4

    Topics: Analysis of Variance; Animals; Cardiac Output; Epinephrine; Glycogen; Heart; Heart Rate; Hypoxia; Is

2004
Occult hypoperfusion is associated with increased mortality in hemodynamically stable, high-risk, surgical patients.
    Critical care (London, England), 2004, Volume: 8, Issue:2

    Topics: Adult; Aged; Biomarkers; Critical Illness; Female; Hemodynamics; Humans; Hypoxia; Intensive Care Uni

2004
Effect of nutrient deprivation on the viability of intervertebral disc cells.
    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2004, Volume: 13, Issue:8

    Topics: Animals; Cattle; Cell Survival; Cells, Cultured; Chondrocytes; Energy Metabolism; Glucose; Hydrogen-

2004
Influence of chronic hypoxemia on peripheral muscle function and oxidative stress in humans.
    Clinical physiology and functional imaging, 2004, Volume: 24, Issue:2

    Topics: Aged; Chronic Disease; Electromyography; Evoked Potentials; Female; Glutathione; Humans; Hypoxia; La

2004
The regulation and importance of glucose uptake in the isolated Atlantic cod heart: rate-limiting steps and effects of hypoxia.
    The Journal of experimental biology, 2004, Volume: 207, Issue:Pt 11

    Topics: Analysis of Variance; Animals; Biological Transport, Active; Cytochalasin B; Deoxyglucose; Fishes; G

2004
Force development, energy state and ATP production of cardiac muscle from turtles and trout during normoxia and severe hypoxia.
    The Journal of experimental biology, 2004, Volume: 207, Issue:Pt 11

    Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Hydrolysis; Hypoxia; Lactic Acid; Myocardial

2004
Effects of swimming on metabolic recovery from anoxia in the painted turtle.
    The Journal of experimental biology, 2004, Volume: 207, Issue:Pt 15

    Topics: Analysis of Variance; Animals; Blood Chemical Analysis; Energy Metabolism; Hypoxia; Lactic Acid; Oxy

2004
Lactate metabolism at high altitude.
    High altitude medicine & biology, 2004,Summer, Volume: 5, Issue:2

    Topics: Acclimatization; Altitude; Exercise; Female; Humans; Hypoxia; Lactic Acid; Male; Research Design

2004
Patterns of energy substrates during ischemia measured in the brain by microdialysis.
    Journal of neurotrauma, 2004, Volume: 21, Issue:7

    Topics: Adult; Brain Injuries; Brain Ischemia; Female; Glasgow Coma Scale; Glucose; Glutamic Acid; Humans; H

2004
Loss of skeletal muscle HIF-1alpha results in altered exercise endurance.
    PLoS biology, 2004, Volume: 2, Issue:10

    Topics: Adenosine Triphosphate; Alleles; Animals; Creatine Kinase; Crosses, Genetic; Gene Deletion; Gene Exp

2004
Time-dependent expression of heat shock proteins 70 and 90 in tissues of the anoxic western painted turtle.
    The Journal of experimental biology, 2004, Volume: 207, Issue:Pt 21

    Topics: Analysis of Variance; Animals; Blood Glucose; Blotting, Western; Brain; Diving; Female; HSP70 Heat-S

2004
Effects of ephedrine and phenylephrine on uterine and placental circulations and fetal outcome following fetal hypoxaemia and epidural-induced hypotension in a sheep model.
    British journal of anaesthesia, 2004, Volume: 93, Issue:6

    Topics: Acid-Base Equilibrium; Adrenergic alpha-Agonists; Anesthesia, Epidural; Anesthesia, Obstetrical; Ani

2004
A novel cancer therapy: combined liposomal hypoxia inducible factor 1 alpha antisense oligonucleotides and an anticancer drug.
    Biochemical pharmacology, 2004, Nov-15, Volume: 68, Issue:10

    Topics: Apoptosis; Caspases; Doxorubicin; Drug Carriers; Drug Combinations; Drug Delivery Systems; Female; H

2004
ANT2 expression under hypoxic conditions produces opposite cell-cycle behavior in 143B and HepG2 cancer cells.
    Molecular carcinogenesis, 2005, Volume: 42, Issue:1

    Topics: Adenine Nucleotide Translocator 2; Adenine Nucleotide Translocator 3; Gene Expression Regulation, Ne

2005
Cardiorespiratory and tissue adenosine responses to hypoxia and reoxygenation in the short-horned sculpin Myoxocephalus scorpius.
    The Journal of experimental biology, 2004, Volume: 207, Issue:Pt 23

    Topics: Adenosine; Animals; Brain; Calcium; Chromatography, High Pressure Liquid; Fishes; Hypoxia; Lactic Ac

2004
Exercise with the intensity of the individual anaerobic threshold in acute hypoxia.
    Medicine and science in sports and exercise, 2004, Volume: 36, Issue:10

    Topics: Adult; Altitude; Anaerobic Threshold; Blood Glucose; Epinephrine; Exercise; Exercise Test; Heart Rat

2004
Ontogenetic changes and developmental adjustments in lactate dehydrogenase isozymes of an obligate air-breathing fish Channa punctatus during deprivation of air access.
    Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 2005, Volume: 140, Issue:2

    Topics: Adaptation, Physiological; Air; Animals; Asphyxia; Fishes; Hypoxia; Isoenzymes; Kinetics; L-Lactate

2005
Production of organic acids by Corynebacterium glutamicum under oxygen deprivation.
    Applied microbiology and biotechnology, 2005, Volume: 68, Issue:4

    Topics: Corynebacterium glutamicum; Hypoxia; Lactic Acid; Succinic Acid

2005
Hypoxia/reoxygenation reduces microvascular endothelial cell coupling by a tyrosine and MAP kinase dependent pathway.
    Journal of cellular physiology, 2005, Volume: 204, Issue:1

    Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Connexin 43; Electric Conductivity; Endothelial Ce

2005
[Effect of high-oxygen water on enhancing anoxia endurance and anti-fatigue function and the possible mechanism].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2005, Volume: 36, Issue:1

    Topics: Animals; Fatigue; Hypoxia; Hypoxia, Brain; Lactic Acid; Male; Mice; Muscle, Skeletal; Oxygen; Oxygen

2005
Effects of ischaemia-mimetic factors on isolated rat ventricular myocytes.
    Experimental physiology, 2005, Volume: 90, Issue:4

    Topics: Acidosis; Animals; Glucose; Heart Ventricles; Hypoxia; In Vitro Techniques; Lactic Acid; Male; Myoca

2005
[Effect of intermittent hypoxic training on indices of adaptation to hypoxia in rats during physical exertion].
    Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 2004, Volume: 50, Issue:6

    Topics: Adaptation, Physiological; Animals; Hypoxia; Lactic Acid; Male; Mitochondria, Muscle; Muscle, Skelet

2004
Effect of chronic hypoxia during embryonic development on physiological functioning and on hatching and post-hatching parameters related to ascites syndrome in broiler chickens.
    Avian pathology : journal of the W.V.P.A, 2004, Volume: 33, Issue:6

    Topics: Altitude; Animals; Ascites; Chick Embryo; Chickens; Corticosterone; Hypoxia; Lactic Acid; Ovum; Poul

2004
Role of hypoxia-induced anorexia and right ventricular hypertrophy on lactate transport and MCT expression in rat muscle.
    Metabolism: clinical and experimental, 2005, Volume: 54, Issue:5

    Topics: Animals; Anorexia; Biological Transport; Body Weight; Hematocrit; Hypertrophy, Right Ventricular; Hy

2005
Metabolic adjustments in two Amazonian cichlids exposed to hypoxia and anoxia.
    Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 2005, Volume: 141, Issue:3

    Topics: Adaptation, Physiological; Anaerobic Threshold; Animals; Cichlids; Glycogen; Hypoxia; L-Lactate Dehy

2005
Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke.
    Shock (Augusta, Ga.), 2005, Volume: 24, Issue:4

    Topics: Anesthesia; Animals; Brain; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Glutamic Acid;

2005
Growth restriction and the cerebral metabolic response to acute hypoxia of chick embryos in-ovo: a proton magnetic resonance spectroscopy study.
    Brain research. Developmental brain research, 2005, Dec-07, Volume: 160, Issue:2

    Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Aspartic Acid; Cerebellum; Chick Embryo; Fetal Hypoxia; Hyp

2005
Exercise performance in hypoxia after novel erythropoiesis stimulating protein treatment.
    Scandinavian journal of medicine & science in sports, 2006, Volume: 16, Issue:1

    Topics: Adult; Altitude; Erythropoiesis; Exercise; Female; Humans; Hypoxia; Lactic Acid; Male; Oxygen Consum

2006
Limited oxygen diffusion accelerates fatigue development in mouse skeletal muscle.
    The Journal of physiology, 2006, Apr-15, Volume: 572, Issue:Pt 2

    Topics: Action Potentials; Animals; Biological Transport; Calcium; Diffusion; Hypoxia; Lactic Acid; Male; Mi

2006
Plasma lactate and glucose flushes following burst swimming in silver trevally (Pseudocaranx dentex: Carangidae) support the "releaser" hypothesis.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2006, Volume: 143, Issue:3

    Topics: Animals; Blood Glucose; Hypoxia; Lactic Acid; Muscles; Perciformes; Physical Exertion; Swimming

2006
Excitatory amino acid release and electrocortical brain activity after hypoxemia in near-term lambs.
    Brain & development, 2006, Volume: 28, Issue:6

    Topics: Animals; Animals, Newborn; Aspartic Acid; Blood Glucose; Brain; Electroencephalography; Female; Gest

2006
Effect of acute hypoxia on maximal oxygen uptake and maximal performance during leg and upper-body exercise in Nordic combined skiers.
    International journal of sports medicine, 2006, Volume: 27, Issue:4

    Topics: Acute Disease; Adult; Biopsy, Fine-Needle; Ergometry; Heart Rate; Humans; Hypoxia; Lactic Acid; Leg;

2006
Sea-level performance in runners using altitude tents: a field study.
    Journal of science and medicine in sport, 2005, Volume: 8, Issue:4

    Topics: Adult; Altitude; Camping; Case-Control Studies; Equipment and Supplies; Exercise Test; Fatigue; Fema

2005
Persistent suppression of resting energy expenditure after acute hypoxia.
    Metabolism: clinical and experimental, 2006, Volume: 55, Issue:5

    Topics: Adult; Blood Glucose; Cross-Over Studies; Double-Blind Method; Energy Metabolism; Epinephrine; Gluco

2006
Reexamining the hyperglycemic pseudohypoxia hypothesis of diabetic oculopathy.
    Investigative ophthalmology & visual science, 2006, Volume: 47, Issue:6

    Topics: Adenosine Triphosphate; Aldehyde Reductase; Animals; Cell Culture Techniques; Diabetes Mellitus, Exp

2006
Arterial oxygenation influences central motor output and exercise performance via effects on peripheral locomotor muscle fatigue in humans.
    The Journal of physiology, 2006, Sep-15, Volume: 575, Issue:Pt 3

    Topics: Adult; Electromyography; Humans; Hyperoxia; Hypoxia; Lactic Acid; Locomotion; Male; Motor Cortex; Mo

2006
Force development at elevated [Mg2+]o and [K+]o in myocardium from the freshwater turtle (Trachemys scripta) and influence of factors associated with hibernation.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2006, Volume: 145, Issue:3

    Topics: Acidosis; Animals; Calcium; Epinephrine; Heart; Hibernation; Hypoxia; In Vitro Techniques; Lactic Ac

2006
Effect of acute severe hypoxia on peripheral fatigue and endurance capacity in healthy humans.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2007, Volume: 292, Issue:1

    Topics: Adult; Dyspnea; Electromagnetic Fields; Exercise; Exercise Test; Femoral Nerve; Humans; Hypoxia; Lac

2007
Comparative shell buffering properties correlate with anoxia tolerance in freshwater turtles.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2007, Volume: 292, Issue:2

    Topics: Animals; Buffers; Carbon Dioxide; Fresh Water; Hydrogen-Ion Concentration; Hypoxia; Lactic Acid; Min

2007
The impact of hypoxia on in vivo glucose uptake in a hypoglycemic fish, Myoxocephalus scorpius.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2007, Volume: 292, Issue:2

    Topics: Adenosine; Animals; Atropine; Blood Glucose; Brain Chemistry; Carbohydrate Metabolism; Cardiac Outpu

2007
Sex differences in energy metabolism and performance of teleost cardiac tissue.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2007, Volume: 292, Issue:2

    Topics: Animals; Body Weight; Electric Stimulation; Energy Metabolism; Epinephrine; Fatty Acids; Female; Glu

2007
Selected biochemical variables in a model of neonatal anoxia in rats.
    Neuro endocrinology letters, 2006, Volume: 27 Suppl 2

    Topics: Acetylglucosaminidase; Animals; Animals, Newborn; Biomarkers; Brain Chemistry; Disease Models, Anima

2006
Lactate uptake by skeletal bone in anoxic turtles, Trachemys scripta.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2007, Volume: 146, Issue:3

    Topics: Acidosis, Respiratory; Animals; Bone and Bones; Buffers; Cold Temperature; Hypoxia; Lactic Acid; Tur

2007
Fluid resuscitation with hemoglobin-vesicle solution does not increase hypoxia or inflammatory responses in moderate hemorrhagic shock.
    Biomedical research (Tokyo, Japan), 2006, Volume: 27, Issue:6

    Topics: Animals; Blood Pressure; Blood Substitutes; Hemoglobins; Hypoxia; Inflammation; Isotonic Solutions;

2006
Metabolic and ionoregulatory responses of the Amazonian cichlid, Astronotus ocellatus, to severe hypoxia.
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2007, Volume: 177, Issue:3

    Topics: Adaptation, Physiological; Adenosine Triphosphate; Animals; Blood Glucose; Cichlids; Creatine; Eryth

2007
Grave acidosis after severe anaphylactic bronchospasm: friend or foe?
    Acta anaesthesiologica Scandinavica, 2007, Volume: 51, Issue:4

    Topics: Acidosis; Adult; Anaphylaxis; Anti-Inflammatory Agents; Asthma; Blood Gas Analysis; Blood Glucose; B

2007
Myocardial lactate deprivation is associated with decreased cardiovascular performance, decreased myocardial energetics, and early death in endotoxic shock.
    Intensive care medicine, 2007, Volume: 33, Issue:3

    Topics: Analysis of Variance; Animals; Coronary Circulation; Energy Metabolism; Epinephrine; Glycolysis; Hyp

2007
Effect of prior heavy exercise on muscle deoxygenation kinetics at the onset of subsequent heavy exercise.
    European journal of applied physiology, 2007, Volume: 99, Issue:6

    Topics: Adult; Algorithms; Carbon Dioxide; Data Interpretation, Statistical; Exercise; Female; Heart Rate; H

2007
Regulation of 2-deoxy-D-glucose transport, lactate metabolism, and MMP-2 secretion by the hypoxia mimetic cobalt chloride in articular chondrocytes.
    Annals of the New York Academy of Sciences, 2006, Volume: 1091

    Topics: Animals; Biological Transport, Active; Cartilage, Articular; Cells, Cultured; Chondrocytes; Cobalt;

2006
Taurine as a marker for foetal wellbeing?
    Neonatology, 2007, Volume: 91, Issue:3

    Topics: Amino Acids; Animals; Biomarkers; Disease Models, Animal; Female; Fetal Death; Fetal Development; Fe

2007
Protective effect of Portulaca oleracea extracts on hypoxic nerve tissue and its mechanism.
    Asia Pacific journal of clinical nutrition, 2007, Volume: 16 Suppl 1

    Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Hypoxia; L-Lactate Dehydrogenase; Lactic

2007
Effects of temperature on anoxic submergence: skeletal buffering, lactate distribution, and glycogen utilization in the turtle, Trachemys scripta.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2007, Volume: 293, Issue:1

    Topics: Acclimatization; Acid-Base Equilibrium; Animals; Bicarbonates; Blood Glucose; Bone and Bones; Calciu

2007
An in vitro system to evaluate the effects of ischemia on survival of cells used for cell therapy.
    Annals of biomedical engineering, 2007, Volume: 35, Issue:8

    Topics: Animals; Cell Survival; Collagen Type I; Glucose; Hypoxia; In Vitro Techniques; Lactic Acid; Mesench

2007
Flexibility in energy metabolism supports hypoxia tolerance in Drosophila flight muscle: metabolomic and computational systems analysis.
    Molecular systems biology, 2007, Volume: 3

    Topics: Acetates; Adaptation, Physiological; Adenosine Triphosphate; Alanine; Animals; Computational Biology

2007
Temporal differences in the influence of ischemic factors and deformation on the metabolism of engineered skeletal muscle.
    Journal of applied physiology (Bethesda, Md. : 1985), 2007, Volume: 103, Issue:2

    Topics: Animals; Cell Line; Cell Shape; Cell Survival; Disease Models, Animal; Glucose; Hydrogen-Ion Concent

2007
Effects of acute moderate hypoxia on anaerobic capacity in endurance-trained runners.
    European journal of applied physiology, 2007, Volume: 101, Issue:1

    Topics: Acclimatization; Adult; Altitude; Ammonia; Anaerobic Threshold; Atmospheric Pressure; Exercise Test;

2007
The hemodynamic effects of dobutamine during reoxygenation after hypoxia: a dose-response study in newborn pigs.
    Shock (Augusta, Ga.), 2007, Volume: 28, Issue:3

    Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Blood Pressure; Cardiac Output; Dobutamine; Dose-Res

2007
Extreme anoxia tolerance in embryos of the annual killifish Austrofundulus limnaeus: insights from a metabolomics analysis.
    The Journal of experimental biology, 2007, Volume: 210, Issue:Pt 13

    Topics: Amino Acids; Animals; Embryo, Nonmammalian; gamma-Aminobutyric Acid; Hypoxia; Killifishes; Lactic Ac

2007
Arabidopsis NIP2;1, a major intrinsic protein transporter of lactic acid induced by anoxic stress.
    The Journal of biological chemistry, 2007, Aug-17, Volume: 282, Issue:33

    Topics: Anaerobiosis; Aquaporins; Arabidopsis Proteins; Gene Expression Regulation, Plant; Hypoxia; Lactic A

2007
Muscle fatigue increases the probability of developing hyperalgesia in mice.
    The journal of pain, 2007, Volume: 8, Issue:9

    Topics: Animals; Carbon Dioxide; Cumulative Trauma Disorders; Disease Models, Animal; Dose-Response Relation

2007
Preexisting hypoxia is associated with a delayed but more sustained rise in T/QRS ratio during prolonged umbilical cord occlusion in near-term fetal sheep.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2007, Volume: 293, Issue:3

    Topics: Amniotic Fluid; Animals; Blood Gas Analysis; Blood Glucose; Blood Pressure; Carotid Arteries; Data I

2007
The novel hemoglobin-based oxygen carrier HRC 101 improves survival in murine sickle cell disease.
    Anesthesiology, 2007, Volume: 107, Issue:2

    Topics: Albumins; Anemia, Sickle Cell; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Blood Substitut

2007
ICVTS on-line discussion A. Further testing is warranted to detect more subtle degrees...
    Interactive cardiovascular and thoracic surgery, 2007, Volume: 6, Issue:2

    Topics: Anaerobic Threshold; Animals; Cardiopulmonary Bypass; Coronary Artery Bypass; Coronary Artery Diseas

2007
Prediction of the susceptibility to AMS in simulated altitude.
    Sleep & breathing = Schlaf & Atmung, 2008, Volume: 12, Issue:2

    Topics: Acclimatization; Acute Disease; Altitude; Altitude Sickness; Exercise; Humans; Hypercapnia; Hyperven

2008
The influence of anoxia on lactate utilization in man after prolonged muscular work.
    Acta physiologica Scandinavica, 1949, Apr-14, Volume: 17, Issue:4

    Topics: Humans; Hypoxia; Lactates; Lactic Acid; Male; Muscles; Oxygen

1949
Oxidative stress and matrix metalloproteinase-9 activity in the liver after hypoxia and reoxygenation with 21% or 100% oxygen in newborn piglets.
    European journal of pharmacology, 2008, Feb-12, Volume: 580, Issue:3

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Alanine Transaminase; Animal

2008
Effect of seabuckthorn leaf extracts on circulating energy fuels, lipid peroxidation and antioxidant parameters in rats during exposure to cold, hypoxia and restraint (C-H-R) stress and post stress recovery.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2008, Volume: 15, Issue:6-7

    Topics: Animals; Antioxidants; Blood Glucose; Fatty Acids, Nonesterified; Hippophae; Hypothermia; Hypoxia; L

2008
Extracellular pH defense against lactic acid in untrained and trained altitude residents.
    European journal of applied physiology, 2008, Volume: 103, Issue:2

    Topics: Acclimatization; Acid-Base Equilibrium; Acidosis, Lactic; Adaptation, Physiological; Adult; Altitude

2008
Intrapulmonary shunting and pulmonary gas exchange during normoxic and hypoxic exercise in healthy humans.
    Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 104, Issue:5

    Topics: Adolescent; Adult; Blood Gas Analysis; Body Temperature; Data Interpretation, Statistical; Echocardi

2008
Xenon/hypothermia neuroprotection regimes in spontaneously breathing neonatal rats after hypoxic-ischemic insult: the respiratory and sedative effects.
    Anesthesia and analgesia, 2008, Volume: 106, Issue:3

    Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Blood Glucose; Body Temperature; Carbon Dioxide;

2008
Increased aerobic glycolysis through beta2 stimulation is a common mechanism involved in lactate formation during shock states.
    Shock (Augusta, Ga.), 2008, Volume: 30, Issue:4

    Topics: Animals; Epinephrine; Glycolysis; Hypoxia; Lactic Acid; Male; Oxygen; Rats; Rats, Wistar; Receptors,

2008
Aerobic glycolysis in cancers: implications for the usability of oxygen-responsive genes and fluorodeoxyglucose-PET as markers of tissue hypoxia.
    International journal of cancer, 2008, Jun-15, Volume: 122, Issue:12

    Topics: Aerobiosis; Animals; Cell Line, Tumor; Fluorodeoxyglucose F18; Glycolysis; Humans; Hypoxia; Immunohi

2008
Paclitaxel-loaded poly(D,L-lactide-co-glycolide) nanoparticles for radiotherapy in hypoxic human tumor cells in vitro.
    Cancer biology & therapy, 2008, Volume: 7, Issue:6

    Topics: Antineoplastic Agents, Phytogenic; Cell Cycle; Cell Line, Tumor; Cell Survival; Coculture Techniques

2008
Delayed hypothermia as selective head cooling or whole body cooling does not protect brain or body in newborn pig subjected to hypoxia-ischemia.
    Pediatric research, 2008, Volume: 64, Issue:1

    Topics: Animals; Animals, Newborn; Anticonvulsants; Calcium; Cardiotonic Agents; Disease Models, Animal; Fem

2008
One-stop-shop tumor imaging: buy hypoxia, get lactate free.
    The Journal of clinical investigation, 2008, Volume: 118, Issue:5

    Topics: Animals; Electron Spin Resonance Spectroscopy; Hypoxia; Lactic Acid; Magnetic Resonance Imaging; Mic

2008
Evidence that reduced skeletal muscle recruitment explains the lactate paradox during exercise at high altitude.
    Journal of applied physiology (Bethesda, Md. : 1985), 2009, Volume: 106, Issue:2

    Topics: Acclimatization; Altitude; Animals; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lactic Acid; M

2009
The role of hepatic glycogen stores in anaerobic metabolism in rats.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1984, Volume: 79, Issue:1

    Topics: Anaerobiosis; Animals; Blood Glucose; Carbon Monoxide Poisoning; Cyanides; Energy Metabolism; Hypoxi

1984
On the role of cyclic nucleotides in the regulation of cardiac contractility and glycolysis during hypoxia.
    Acta pharmacologica et toxicologica, 1981, Volume: 48, Issue:4

    Topics: Animals; Cyclic AMP; Cyclic GMP; Glycolysis; Hypoxia; Lactates; Lactic Acid; Male; Myocardial Contra

1981
Sodium nitroprusside inhibits lactate formation in rat atria: is cyclic GMP involved?
    Acta pharmacologica et toxicologica, 1983, Volume: 52, Issue:3

    Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Ferricyanides; Glycolysis; Hypothermia; Hypox

1983
Studies on experimental growth retardation in sheep. The effects of maternal hypoxaemia.
    Journal of developmental physiology, 1983, Volume: 5, Issue:2

    Topics: Adrenocorticotropic Hormone; Animals; Blood Glucose; Endometrium; Female; Fetal Growth Retardation;

1983
The effects of cyclic AMP and cyclic GMP on redox state and energy state in hypoxic rat atria.
    Life sciences, 1984, Jul-09, Volume: 35, Issue:2

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenine Nucleotides; Animals; Cyclic GMP; Energy Metabolism;

1984
Biological time-related changes in tolerance of male rats to hypoxia--I. Survival rate and carbohydrate metabolism.
    Chronobiology international, 1984, Volume: 1, Issue:4

    Topics: Activity Cycles; Animals; Blood Glucose; Brain Chemistry; Carbohydrate Metabolism; Circadian Rhythm;

1984
On the seemingly diminished CO2-Bohr effect in hypoxic chemodenervated rabbits.
    Advances in experimental medicine and biology, 1984, Volume: 169

    Topics: 2,3-Diphosphoglycerate; Animals; Carbon Dioxide; Chemical Phenomena; Chemistry, Physical; Diffusion;

1984
Small bowel and liver gas tensions during intravenous vasopressin infusion and 60% oxygen ventilation.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1984, Volume: 184, Issue:4

    Topics: Animals; Carbon Dioxide; Hypoxia; Intestine, Small; Lactates; Lactic Acid; Liver; Oxygen; Swine; Vas

1984
Trends in continuous metabolic monitoring during experimental fetal distress.
    American journal of perinatology, 1984, Volume: 1, Issue:4

    Topics: Animals; Carbon Dioxide; Dogs; Electrocardiography; Female; Fetal Blood; Fetal Distress; Fetal Monit

1984
Splanchnic vasomotor and metabolic adjustments to hypoxia and exercise in humans.
    The American journal of physiology, 1984, Volume: 247, Issue:2 Pt 2

    Topics: Adult; Blood Pressure; Epinephrine; Heart Rate; Humans; Hypoxia; Indocyanine Green; Lactates; Lactic

1984
Metabolic consequences of induced hypoxia in newborn lambs.
    Annales de recherches veterinaires. Annals of veterinary research, 1984, Volume: 15, Issue:1

    Topics: Animals; Animals, Newborn; Blood Glucose; Body Temperature; Fatty Acids, Nonesterified; Hematocrit;

1984
Effect of an extract of Ginkgo biloba on rat brain energy metabolism in hypoxia.
    Naunyn-Schmiedeberg's archives of pharmacology, 1984, Volume: 327, Issue:1

    Topics: Animals; Brain; Energy Metabolism; Hypoxia; Lactates; Lactic Acid; Male; Plant Extracts; Plants, Med

1984
Role of glycolytic products in damage to ischemic myocardium. Dissociation of adenosine triphosphate levels and recovery of function of reperfused ischemic hearts.
    Circulation research, 1984, Volume: 55, Issue:6

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Calcium; Coronary C

1984
Different effects of acute ischemia and anoxia on the canine myocardium.
    Japanese heart journal, 1984, Volume: 25, Issue:5

    Topics: Acute Disease; Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Disease; Dogs; Female

1984
[The effect of Co-enzyme Q10 on lactate metabolism during resuscitation from anoxia].
    Masui. The Japanese journal of anesthesiology, 1984, Volume: 33, Issue:12

    Topics: Animals; Coenzymes; Energy Metabolism; Hypoxia; Lactates; Lactic Acid; Rabbits; Resuscitation; Ubiqu

1984
High-resolution 1H nuclear magnetic resonance study of cerebral hypoxia in vivo.
    Proceedings of the National Academy of Sciences of the United States of America, 1983, Volume: 80, Issue:16

    Topics: Animals; Cerebral Cortex; Heart Rate; Hypoxia; Kinetics; Lactates; Lactic Acid; Magnetic Resonance S

1983
Detection of cerebral lactate in vivo during hypoxemia by 1H NMR at relatively low field strengths (1.9 T).
    Proceedings of the National Academy of Sciences of the United States of America, 1984, Volume: 81, Issue:8

    Topics: Anaerobiosis; Animals; Blood Pressure; Brain; Female; Heart Rate; Hypoxia; Kinetics; Lactates; Lacti

1984
Possible mechanisms for reoxygenation-induced recovery of myocardial high-energy phosphates after hypoxia.
    Journal of molecular and cellular cardiology, 1983, Volume: 15, Issue:9

    Topics: Adenine Nucleotides; Animals; Creatine Kinase; Energy Metabolism; Female; Heart; Hemodynamics; Hypox

1983
Lactate production in a pure red muscle in absence of anoxia: mechanisms and significance.
    Advances in experimental medicine and biology, 1983, Volume: 159

    Topics: Animals; Dogs; Glycolysis; Hypoxia; In Vitro Techniques; Kinetics; Lactates; Lactic Acid; Mitochondr

1983
[Acid-base equilibrium, blood lactic acid and pyruvic acid in albino rats after muscular exertion under conditions of normal oxygen, hypoxia and hypoxia-hypercapnia].
    Bollettino della Societa italiana di biologia sperimentale, 1984, Mar-30, Volume: 60, Issue:3

    Topics: Acid-Base Equilibrium; Animals; Hypercapnia; Hypoxia; Lactates; Lactic Acid; Male; Physical Exertion

1984
[Effects of muscular exertion in a hypoxic and hypoxic-hypercapnic respiratory environment on acid-base equilibrium and blood lactic acid in the albino rat raised in hypoxic hypoxia from birth].
    Bollettino della Societa italiana di biologia sperimentale, 1984, Mar-30, Volume: 60, Issue:3

    Topics: Acid-Base Equilibrium; Animals; Bicarbonates; Hypercapnia; Hypoxia; Lactates; Lactic Acid; Male; Phy

1984
Purine metabolites and lactate as parameters of hypoxia in the newborn infant.
    Pediatric research, 1984, Volume: 18, Issue:4

    Topics: Asphyxia Neonatorum; Humans; Hypoxanthines; Hypoxia; Infant, Newborn; Lactates; Lactic Acid; Purines

1984
Lactate and regulation of lung glycolytic rate.
    The American journal of physiology, 1984, Volume: 246, Issue:5 Pt 1

    Topics: Animals; Glycolysis; Hypoxia; Kinetics; Lactates; Lactic Acid; Lung; Male; Pyruvates; Pyruvic Acid;

1984
Lactate and pyruvate production in isolated thiamine-deficient rat diaphragm strips.
    Canadian journal of physiology and pharmacology, 1984, Volume: 62, Issue:3

    Topics: Animals; Diaphragm; Fatigue; Glucose; Glycolysis; Hydrogen; Hypoxia; In Vitro Techniques; Lactates;

1984
Deleterious effects of oxygen radicals on reoxygenated myocardial cells.
    Advances in experimental medicine and biology, 1984, Volume: 169

    Topics: Animals; Catalase; Coronary Circulation; Creatine Kinase; Energy Metabolism; Free Radicals; Glutathi

1984
Studies on the ability of kidney cells to recover after periods of anoxia.
    Advances in experimental medicine and biology, 1984, Volume: 169

    Topics: Aerobiosis; Animals; Gluconeogenesis; Hypoxia; In Vitro Techniques; Kidney; Kidney Cortex; Kidney Tu

1984
Relation between enzyme release and metabolic changes in reversible anoxic injury of myocardial cells.
    Life sciences, 1984, Jul-09, Volume: 35, Issue:2

    Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Glucose-6-Phosphate; Glucosephosphates; Glutamate

1984
Diffusion-limited gas exchange across amphibian skin.
    Federation proceedings, 1982, Volume: 41, Issue:6

    Topics: Adenosine Triphosphate; Animals; Atmospheric Pressure; Carbon Dioxide; Diffusion; Hypoxia; Lactates;

1982
Influence of age upon the cerebral metabolic changes induced by acute hypoxia on the synaptosomes from dog brain.
    Experimental gerontology, 1982, Volume: 17, Issue:1

    Topics: Adenine Nucleotides; Aging; Animals; Dihydroergotoxine; Dogs; Female; Hypoxia; Lactates; Lactic Acid

1982
Effects of hypoxia on blood gas and acid-base parameters of sea bass.
    Journal of applied physiology: respiratory, environmental and exercise physiology, 1982, Volume: 53, Issue:6

    Topics: Acid-Base Equilibrium; Animals; Bicarbonates; Carbon Dioxide; Fishes; Hydrogen-Ion Concentration; Hy

1982
Control of ventilation in running birds: effects of hypoxia, hyperoxia, and CO2.
    Journal of applied physiology: respiratory, environmental and exercise physiology, 1982, Volume: 53, Issue:6

    Topics: Animals; Carbon Dioxide; Chickens; Hypercapnia; Hypoxia; Lactates; Lactic Acid; Oxygen; Physical Exe

1982
Aortic and carotid chemoreceptor responses to metabolic acidosis in the cat.
    The American journal of physiology, 1983, Volume: 244, Issue:5

    Topics: Acidosis; Afferent Pathways; Animals; Aorta; Carotid Body; Cats; Chemoreceptor Cells; Female; Hydrog

1983
Effects of extreme hypoxia on the growth and viability of EMT6/SF mouse tumor cells in vitro.
    Cancer research, 1983, Volume: 43, Issue:8

    Topics: Animals; Cell Cycle; Cell Survival; Cells, Cultured; DNA Replication; Glucose; Hypoxia; Lactates; La

1983
Effect of postnatal hypoxia on the energy homeostasis of the newborn rat during the early neonatal period.
    Biology of the neonate, 1983, Volume: 44, Issue:1

    Topics: Adenine Nucleotides; Alanine; Animals; Animals, Newborn; Blood Glucose; Energy Metabolism; Glucagon;

1983
Hypoxanthine as a test of perinatal hypoxia as compared to lactate, base deficit, and pH.
    Pediatric research, 1982, Volume: 16, Issue:2

    Topics: Acid-Base Imbalance; Asphyxia Neonatorum; Humans; Hydrogen-Ion Concentration; Hypoxanthine; Hypoxant

1982
The effects of induced hypoxia on the cardiovascular system in dogs poisoned with tetanus toxin.
    Naunyn-Schmiedeberg's archives of pharmacology, 1982, Volume: 318, Issue:3

    Topics: Animals; Atropine; Blood Gas Analysis; Dogs; Female; Hemodynamics; Hypoxia; Lactates; Lactic Acid; M

1982
Fetal myocardial oxygen and carbohydrate consumption during acutely induced hypoxemia.
    The American journal of physiology, 1982, Volume: 242, Issue:4

    Topics: Animals; Blood Pressure; Coronary Circulation; Female; Fetus; Glucose; Heart; Heart Rate; Hypoxia; L

1982
[Experimental polycythemia induced by lactate in Tritons].
    Bollettino della Societa italiana di biologia sperimentale, 1982, Apr-15, Volume: 58, Issue:7

    Topics: Animals; Erythrocyte Count; Erythropoiesis; Female; Hypoxia; Lactates; Lactic Acid; Male; Polycythem

1982
Cerebral arterio-venous difference for hypoxanthine and lactate during graded asphyxia in the fetal lamb.
    Brain research, 1982, May-06, Volume: 239, Issue:1

    Topics: Animals; Asphyxia; Blood Pressure; Cerebral Arteries; Cerebrovascular Circulation; Evoked Potentials

1982
Role of mitochondrial oxidative phosphorylation in regulation of coronary blood flow.
    The American journal of physiology, 1982, Volume: 243, Issue:2

    Topics: Adenosine; Amobarbital; Animals; Calcium; Coronary Circulation; Hypoxanthines; Hypoxia; Inosine; Lac

1982
Liver adenosine triphosphate (ATP) in hypoxia and hemorrhagic shock.
    The Journal of trauma, 1982, Volume: 22, Issue:9

    Topics: Acidosis, Respiratory; Adenosine Triphosphate; Animals; Arteries; Hydrogen-Ion Concentration; Hypoxi

1982
Intracellular oxygen supply during hypoxia.
    The American journal of physiology, 1982, Volume: 243, Issue:5

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Anaerobiosis; Animals; Cytochromes; Glutathione; Hypo

1982
Plasma ion balance of submerged anoxic turtles at 3 degrees C: the role of calcium lactate formation.
    Respiration physiology, 1982, Volume: 49, Issue:2

    Topics: Animals; Bicarbonates; Calcium; Hypoxia; Immersion; Ions; Lactates; Lactic Acid; Magnesium; Osmolar

1982
Fetal myocardial oxygen and carbohydrate metabolism in sustained hypoxemia in utero.
    The American journal of physiology, 1982, Volume: 243, Issue:6

    Topics: Animals; Blood Glucose; Carbohydrate Metabolism; Coronary Vessels; Female; Fetus; Heart; Hypoxia; La

1982
Influence of hypothermia or hyperthermia alone or in combination with pentobarbital or phenytoin on survival time in hypoxic mice.
    Anesthesia and analgesia, 1981, Volume: 60, Issue:12

    Topics: Animals; Body Temperature; Brain; Energy Metabolism; Hypothermia, Induced; Hypoxia; Lactates; Lactic

1981
Metabolic changes induced by acute hypoxia on the synaptosomes from dog brain.
    European neurology, 1981, Volume: 20, Issue:3

    Topics: Adenine Nucleotides; Animals; Cerebral Cortex; Dogs; Female; Hypoxia; Lactates; Lactic Acid; Oxygen

1981
Proteolysis in the rat lung: hypoxia and evidence for an inhibitor of proteolysis.
    The American journal of physiology, 1981, Volume: 241, Issue:2

    Topics: Adenosine Triphosphate; Animals; Carbon Radioisotopes; Cell-Free System; Cytosol; Hemoglobins; Hypox

1981
Oxygen consumption in rabbit Langendorff hearts perfused with a saline medium.
    Acta physiologica Scandinavica, 1981, Volume: 113, Issue:1

    Topics: Animals; Culture Media; Female; Hypoxia; Lactates; Lactic Acid; Male; Myocardium; Oxygen Consumption

1981
Canine cerebral metabolism and blood flow during hypoxemia and normoxic recovery from hypoxemia.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1981, Volume: 1, Issue:3

    Topics: Acidosis; Adenine Nucleotides; Animals; Brain; Dogs; Electroencephalography; Glucose; Hypoxia; Lacta

1981
Metabolic alterations accompany ionic disturbances and cellular swelling during a hypoxic insult to the retina: an in vitro study.
    Acta neurochirurgica. Supplementum, 1994, Volume: 60

    Topics: Animals; Blood Glucose; Calcium; Cell Hypoxia; Cell Membrane Permeability; Cell Survival; Culture Te

1994
Cerebral energy metabolism during hypoxaemia. A 31P and 1H magnetic resonance study.
    Acta physiologica Scandinavica, 1995, Volume: 154, Issue:2

    Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Energy Metabolism; Hemodynamics; Humans; Hydrogen-Io

1995
Effects of energy demand in ischemic and in hypoxemic isolated rat hearts.
    Advances in experimental medicine and biology, 1994, Volume: 361

    Topics: Anaerobiosis; Animals; Energy Metabolism; Glycolysis; Hypoxia; In Vitro Techniques; Lactates; Lactic

1994
Restriction of hypoxic membrane defect by glycine improves mitochondrial and cellular function in reoxygenated renal tubules.
    Advances in experimental medicine and biology, 1994, Volume: 361

    Topics: Acetylglucosaminidase; Animals; Glutamate Dehydrogenase; Glycine; Hypoxia; In Vitro Techniques; Kidn

1994
Prognostic value of hyperlactatemia in neonates.
    The Journal of pediatrics, 1995, Volume: 127, Issue:2

    Topics: Extracorporeal Membrane Oxygenation; Humans; Hypoxia; Infant, Newborn; Lactates; Lactic Acid; Predic

1995
Training in hypoxia vs. training in normoxia in high-altitude natives.
    Journal of applied physiology (Bethesda, Md. : 1985), 1995, Volume: 78, Issue:6

    Topics: Adult; Altitude; Bicarbonates; Exercise; Heart Rate; Hemodynamics; Humans; Hypoxia; Lactates; Lactic

1995
Effect of hypoxia on muscle oxygenation and metabolism during arm exercise in humans.
    Clinical physiology (Oxford, England), 1995, Volume: 15, Issue:1

    Topics: Adult; Arm; Blood Gas Analysis; Catecholamines; Exercise; Humans; Hypoxia; Lactates; Lactic Acid; Ma

1995
Effect of galactosamine-induced hepatitis on the aerobic and anaerobic metabolism of the rat exposed to high-altitude hypoxia.
    Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 1995, Volume: 110, Issue:1

    Topics: Aerobiosis; Altitude; Anaerobiosis; Animals; Citrate (si)-Synthase; Energy Metabolism; Fatty Acids;

1995
Mechanism of gluconeogenesis inhibition in rat hepatocytes isolated after in vivo hypoxia.
    The American journal of physiology, 1995, Volume: 268, Issue:5 Pt 1

    Topics: Adenine Nucleotides; Animals; Cell Separation; Dihydroxyacetone; Gluconeogenesis; Hypoxia; Lactates;

1995
Endocrine responses of fetal sheep to prolonged hypoxemia with and without acidemia: relation to urine production.
    The American journal of physiology, 1995, Volume: 268, Issue:5 Pt 2

    Topics: Acids; Animals; Blood Glucose; Blood Pressure; Diuresis; Endocrine Glands; Female; Fetal Blood; Fetu

1995
Stimulation of glycolysis by histidine buffers in mammalian liver during cold hypoxia.
    Archives of biochemistry and biophysics, 1995, Jun-20, Volume: 320, Issue:1

    Topics: Adenine Nucleotides; Anaerobiosis; Animals; Buffers; Carnosine; Cold Temperature; Energy Metabolism;

1995
Detection of tissue hypoxia by arteriovenous gradient for PCO2 and pH in anesthetized dogs during progressive hemorrhage.
    Anesthesia and analgesia, 1995, Volume: 80, Issue:2

    Topics: Animals; Carbon Dioxide; Dogs; Hemorrhage; Hydrogen-Ion Concentration; Hypoxia; Lactates; Lactic Aci

1995
Muscle energetics in short-term training during hypoxia in elite combination skiers.
    European journal of applied physiology and occupational physiology, 1994, Volume: 69, Issue:4

    Topics: Adult; Altitude; Blood Gas Analysis; Cold Temperature; Humans; Hydrogen-Ion Concentration; Hypoxia;

1994
Modification of the responses of endothelin-1 to exhaustive physical exercise under simulated high-altitude conditions with acute hypoxia.
    Metabolism: clinical and experimental, 1995, Volume: 44, Issue:1

    Topics: Acute Disease; Adult; Altitude; Endothelins; Humans; Hydrocortisone; Hypoxia; Lactates; Lactic Acid;

1995
Immediate responses of endothelial cells to hypoxia and reoxygenation: an in vitro model of cellular dysfunction.
    The American journal of physiology, 1995, Volume: 268, Issue:2 Pt 2

    Topics: Animals; Arachidonic Acid; Cattle; Cell Count; Cells, Cultured; Endothelium, Vascular; Epoprostenol;

1995
Oxygen, glucose, and lactate uptake by fetus and placenta during prolonged hypoxemia.
    The American journal of physiology, 1995, Volume: 268, Issue:2 Pt 2

    Topics: Animals; Arteries; Female; Fetal Blood; Fetus; Gases; Glucose; Hydrogen-Ion Concentration; Hypoxia;

1995
Blood lactate and acid-base balance in graded neonatal hypoxia: evidence for oxygen-restricted metabolism.
    Journal of applied physiology (Bethesda, Md. : 1985), 1994, Volume: 77, Issue:5

    Topics: Acid-Base Equilibrium; Acidosis; Anaerobic Threshold; Analysis of Variance; Animals; Animals, Newbor

1994
Comparison of effects of aprikalim and of hypoxic and ischaemic preconditioning on extracellular potassium accumulation, metabolism, and functional recovery of the globally ischaemic rat heart.
    Cardiovascular research, 1994, Volume: 28, Issue:6

    Topics: Animals; Antihypertensive Agents; Basal Metabolism; Extracellular Space; Heart; Hypoxia; Lactates; L

1994
Protection of atrial function in hypoxia by high potassium concentration.
    General pharmacology, 1994, Volume: 25, Issue:3

    Topics: Adenine Nucleotides; Animals; Cardiac Pacing, Artificial; Diastole; Energy Metabolism; Evaluation St

1994
Hydroxymalonate inhibits lactate uptake by the rabbit hindlimb.
    Journal of applied physiology (Bethesda, Md. : 1985), 1994, Volume: 76, Issue:6

    Topics: Animals; Blood Gas Analysis; Blood Glucose; Cardiac Output; Electric Stimulation; Female; Hindlimb;

1994
Plasma lactate concentration as a predictor of death in neonates with severe hypoxemia requiring extracorporeal membrane oxygenation.
    The Journal of pediatrics, 1994, Volume: 125, Issue:5 Pt 1

    Topics: Biomarkers; Case-Control Studies; Extracorporeal Membrane Oxygenation; Hemodynamics; Humans; Hypoxia

1994
Effect of lactic and CO2 acidosis on neuronal function following glucose-oxygen deprivation in rat hippocampal slices.
    Brain research, 1994, Aug-22, Volume: 654, Issue:2

    Topics: Acidosis, Lactic; Acidosis, Respiratory; Animals; Carbon Dioxide; Female; Glucose; Hippocampus; Hydr

1994
Neuropeptide Y release from human heart is enhanced during prolonged exercise in hypoxia.
    Journal of applied physiology (Bethesda, Md. : 1985), 1994, Volume: 76, Issue:3

    Topics: Adult; Carbon Dioxide; Cardiac Output; Coronary Circulation; Exercise; Exercise Test; Heart Rate; Hu

1994
Effect of hypoxia and hyperoxia on human +Gz duration tolerance.
    Journal of applied physiology (Bethesda, Md. : 1985), 1994, Volume: 76, Issue:4

    Topics: Acceleration; Adult; Aerobiosis; Anaerobiosis; Electroencephalography; Gravitation; Gravity Suits; H

1994
Bronchial smooth muscle energetics: effect of iodoacetate and hypoxia.
    Respiration physiology, 1994, Volume: 96, Issue:2-3

    Topics: Animals; Bronchi; Carbachol; Cattle; Energy Metabolism; Hypoxia; In Vitro Techniques; Iodoacetates;

1994
Superresistance against hypoxia after preliminary adaptation to repeated stress.
    Journal of applied physiology (Bethesda, Md. : 1985), 1994, Volume: 76, Issue:5

    Topics: Acid-Base Equilibrium; Adaptation, Physiological; Animals; Blood Gas Analysis; Fatty Acids, Nonester

1994
Metabolic recovery of isolated working rat heart after brief global ischemia.
    The American journal of physiology, 1994, Volume: 267, Issue:2 Pt 2

    Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Animals; Fasting; Glucose-6-Phosphate; Glucosephospha

1994
[Effects of fructose on left ventricular function during hypoxia].
    Masui. The Japanese journal of anesthesiology, 1994, Volume: 43, Issue:6

    Topics: Acidosis, Lactic; Anesthesia; Animals; Blood Glucose; Dogs; Fructose; Hypoxia; Lactates; Lactic Acid

1994
Ipsilateral and contralateral testicular biochemical acute changes after unilateral testicular torsion and detorsion.
    Urology, 1994, Volume: 44, Issue:3

    Topics: Animals; Hypoxanthine; Hypoxanthines; Hypoxia; Lactates; Lactic Acid; Lipid Peroxidation; Male; Rats

1994
Increased oxygen affinity contributes to tissue hypoxia in critically ill patients with low oxygen delivery.
    Advances in experimental medicine and biology, 1994, Volume: 345

    Topics: Biological Transport, Active; Critical Illness; Humans; Hypoxia; Lactates; Lactic Acid; Multiple Org

1994
Cerebral energy metabolism in fetal guinea pigs during moderate maternal hypoxemia at 0.75 of gestation.
    Journal of developmental physiology, 1993, Volume: 19, Issue:5

    Topics: Animals; Brain; Embryonic and Fetal Development; Energy Metabolism; Fetus; Glycolysis; Guinea Pigs;

1993
Cerebral glucose and energy utilization during the evolution of hypoxic-ischemic brain damage in the immature rat.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1994, Volume: 14, Issue:2

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Animals, Newborn; Brain; Brain Ischemia; Energy Metab

1994
Myocardial lactate release during prolonged exercise under hypoxaemia.
    Acta physiologica Scandinavica, 1993, Volume: 149, Issue:4

    Topics: Adult; Exercise; Humans; Hypoxia; Lactates; Lactic Acid; Male; Myocardium; Oxygen; Time Factors

1993
Cerebral metabolism during sustained hypoxemia in preterm fetal sheep.
    American journal of obstetrics and gynecology, 1994, Volume: 170, Issue:3

    Topics: Animals; Brain; Cerebrovascular Circulation; Fetal Hypoxia; Fetus; Gestational Age; Glucose; Hypoxia

1994
Relationship between intracellular pH and metabolite concentrations during metabolic inhibition in isolated ferret heart.
    The Journal of physiology, 1993, Volume: 472

    Topics: Acidosis; Adenosine Triphosphate; Animals; Cyanides; Ferrets; Glycolysis; Heart; Hydrogen-Ion Concen

1993
Fatigue and exhaustion in chronic hypobaric hypoxia: influence of exercising muscle mass.
    Journal of applied physiology (Bethesda, Md. : 1985), 1994, Volume: 76, Issue:2

    Topics: Adult; Altitude; Chronic Disease; Electromyography; Fatigue; Forearm; Humans; Hypoxia; Lactates; Lac

1994
Recovery of the ovine fetus from sustained hypoxia: effects on endocrine, cardiovascular, and biophysical activity.
    American journal of obstetrics and gynecology, 1994, Volume: 170, Issue:5 Pt 1

    Topics: Animals; Blood Glucose; Carbon Dioxide; Cardiovascular System; Electrophysiology; Endocrine Glands;

1994
The effects of twenty-four hours of reduced uterine blood flow on fetal fluid balance in sheep.
    American journal of obstetrics and gynecology, 1994, Volume: 170, Issue:5 Pt 1

    Topics: Amniotic Fluid; Animals; Deglutition; Diuresis; Electrolytes; Female; Fetal Blood; Fetal Diseases; F

1994
Swallowing and urine flow responses of ovine fetuses to 24 h of hypoxia.
    The American journal of physiology, 1994, Volume: 266, Issue:4 Pt 2

    Topics: Animals; Blood Glucose; Body Fluids; Circadian Rhythm; Deglutition; Diuresis; Electrolytes; Female;

1994
Interstitial purine metabolites and lactate during regional myocardial hypoxia.
    Cardiovascular research, 1993, Volume: 27, Issue:8

    Topics: Adenosine; Animals; Cardiomyopathies; Coronary Circulation; Dialysis; Dogs; Extracellular Space; Fem

1993
Net uptake of lactate by rabbit hindlimb during hypoxia.
    The American review of respiratory disease, 1993, Volume: 148, Issue:5

    Topics: Animals; Blood Glucose; Blood Pressure; Cardiac Output; Female; Glucose; Hemoglobins; Hindlimb; Hydr

1993
Influence of stimulation parameters on the release of adenosine, lactate and CO2 from contracting dog gracilis muscle.
    The Journal of physiology, 1993, Volume: 463

    Topics: Adenosine; Animals; Blood Gas Analysis; Carbon Dioxide; Dogs; Electric Stimulation; Hemodynamics; Hy

1993
Fluorocarbon simulation of myocardial ischaemia and reperfusion: studies of relationships between force and intracellular calcium.
    Cardiovascular research, 1993, Volume: 27, Issue:10

    Topics: Animals; Calcium; Calcium-Transporting ATPases; Ferrets; Fluorocarbons; Hypoxia; Intracellular Fluid

1993
Dynamics of myocardial lactate efflux after a step in heart rate in isolated rabbit hearts.
    The American journal of physiology, 1993, Volume: 265, Issue:6 Pt 2

    Topics: Animals; Female; Glucose; Heart Rate; Hypoxia; In Vitro Techniques; Lactates; Lactic Acid; Male; Myo

1993
Interaction between temperature and hypoxia in the alligator.
    The American journal of physiology, 1993, Volume: 265, Issue:6 Pt 2

    Topics: Alligators and Crocodiles; Animals; Body Temperature; Hydrogen-Ion Concentration; Hyperventilation;

1993
Hypoxia selectively excites vasomotor neurons of rostral ventrolateral medulla in rats.
    The American journal of physiology, 1994, Volume: 266, Issue:1 Pt 2

    Topics: Animals; Arteries; Bicarbonates; Chemoreceptor Cells; Denervation; Hydrogen; Hypoxia; Iontophoresis;

1994
Effects of training in normoxia and normobaric hypoxia on human muscle ultrastructure.
    Pflugers Archiv : European journal of physiology, 1993, Volume: 425, Issue:3-4

    Topics: Adult; Atmospheric Pressure; Bicycling; Humans; Hypoxia; Lactates; Lactic Acid; Male; Mitochondria,

1993
Myocardial oxygen supply and lactate metabolism during marked arterial hypoxaemia.
    Acta physiologica Scandinavica, 1993, Volume: 149, Issue:3

    Topics: Adenosine Triphosphate; Adult; Arteries; Carbon Dioxide; Coronary Circulation; Humans; Hypoxia; Lact

1993
Interstitial lactate and glucose concentrations of the isolated perfused rat heart before, during and after anoxia.
    Pflugers Archiv : European journal of physiology, 1993, Volume: 423, Issue:3-4

    Topics: Animals; Capillary Permeability; Coronary Circulation; Extracellular Space; Female; Glucose; Heart;

1993
Hypoxic preconditioning attenuates stunning caused by repeated coronary artery occlusions in dog heart.
    Cardiovascular research, 1993, Volume: 27, Issue:4

    Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Disease; Dogs; Female; Hypoxia; Lact

1993
The effect of normocapnic hypoxia and the duration of exposure to hypoxia on supramaximal exercise performance.
    European journal of applied physiology and occupational physiology, 1993, Volume: 66, Issue:5

    Topics: Adult; Alkalosis; Anaerobiosis; Bicycling; Blood Gas Analysis; Carbon Dioxide; Exercise; Exercise Te

1993
Comparative effects of ischemia and hypoxemia on left ventricular systolic and diastolic function in humans.
    Circulation, 1993, Volume: 88, Issue:2

    Topics: Adult; Aged; Coronary Circulation; Diastole; Female; Humans; Hydrogen; Hypoxia; Lactates; Lactic Aci

1993
Oxygen extraction is altered by endotoxin during tamponade-induced stagnant hypoxia in the dog.
    Circulatory shock, 1993, Volume: 40, Issue:3

    Topics: Animals; Blood Pressure; Cardiac Tamponade; Dogs; Endotoxins; Hypoxia; Lactates; Lactic Acid; Oxygen

1993
Adenosine effect on lactate and pyruvate production in the hypoxic guinea pig heart.
    The International journal of biochemistry, 1993, Volume: 25, Issue:5

    Topics: Adenosine; Animals; Guinea Pigs; Heart; Hypoxia; In Vitro Techniques; Lactates; Lactic Acid; Myocard

1993
[Left ventricular function during hypoxia--II: Effects of intramyocardial pH].
    Masui. The Japanese journal of anesthesiology, 1993, Volume: 42, Issue:7

    Topics: Animals; Dogs; Glucose; Hydrogen-Ion Concentration; Hypoxia; Lactates; Lactic Acid; Myocardium; Vent

1993
Effect of sepsis on brain energy metabolism in normoxic and hypoxic rats.
    Circulatory shock, 1993, Volume: 40, Issue:4

    Topics: Animals; Brain; Energy Metabolism; Female; Hypoxia; Lactates; Lactic Acid; Magnetic Resonance Spectr

1993
Severe hypoxia decreases oxygen uptake relative to intensity during submaximal graded exercise.
    European journal of applied physiology and occupational physiology, 1993, Volume: 67, Issue:1

    Topics: Adult; Exercise; Humans; Hypoxia; Lactates; Lactic Acid; Male; Oxygen Consumption

1993
Effects of indomethacin on brain blood flow and cerebral metabolism in hypoxic newborn piglets.
    The American journal of physiology, 1993, Volume: 264, Issue:1 Pt 2

    Topics: Animals; Animals, Newborn; Arteries; Brain; Cerebrovascular Circulation; Dose-Response Relationship,

1993
Fetal pH improvement after 24 h of severe, nonlethal hypoxia.
    Biology of the neonate, 1993, Volume: 63, Issue:2

    Topics: Animals; Bicarbonates; Fetal Blood; Hindlimb; Hydrogen-Ion Concentration; Hypoxia; Lactates; Lactic

1993
Effect of acute hypoxia on metabolism and ventilation in awake piglets.
    Respiration physiology, 1993, Volume: 91, Issue:2-3

    Topics: Animals; Carbon Dioxide; Hypoxia; Lactates; Lactic Acid; Oxygen; Oxygen Consumption; Pyruvates; Pyru

1993
Mechanisms of reoxygenation-induced calcium overload in cardiac myocytes: dependence on pHi.
    The Journal of surgical research, 1995, Volume: 59, Issue:6

    Topics: Acids; Animals; Animals, Newborn; Calcium; Cells, Cultured; Hydrogen-Ion Concentration; Hypoxia; Lac

1995
Blood pressure and cardiovascular reflex development in fetal sheep. Relation to hypoxaemia, weight, and blood glucose.
    Reproduction, fertility, and development, 1995, Volume: 7, Issue:3

    Topics: Animals; Baroreflex; Blood Glucose; Blood Pressure; Body Weight; Cardiovascular Physiological Phenom

1995
Phosphate excretion during 24 h of hypoxia in conscious rats.
    Acta physiologica Scandinavica, 1995, Volume: 155, Issue:3

    Topics: Animals; Blood Gas Analysis; Consciousness; Cyclic AMP; Homeostasis; Hydrocortisone; Hypoxia; Lactat

1995
The role of accumulation of sodium and calcium on contractile failure of the hypoxic/reoxygenated heart.
    Japanese heart journal, 1996, Volume: 37, Issue:1

    Topics: Adenosine Triphosphate; Animals; Calcium; Cell Membrane Permeability; Energy Metabolism; Hypoxia; In

1996
Plasma lactate as a predictor of early childhood neurodevelopmental outcome of neonates with severe hypoxaemia requiring extracorporeal membrane oxygenation.
    Archives of disease in childhood. Fetal and neonatal edition, 1996, Volume: 74, Issue:1

    Topics: Biomarkers; Developmental Disabilities; Extracorporeal Membrane Oxygenation; Humans; Hypoxia; Infant

1996
Circulatory effects of hypoxia, acute normovolemic hemodilution, and their combination in anesthetized pigs.
    Anesthesiology, 1996, Volume: 84, Issue:6

    Topics: Anesthesia; Animals; Coronary Circulation; Hematocrit; Hemodilution; Hypoxia; Lactates; Lactic Acid;

1996
Alkali therapy extends the period of survival during hypoxia: studies in rats.
    The American journal of physiology, 1996, Volume: 271, Issue:2 Pt 2

    Topics: Acidosis, Lactic; Adenosine Triphosphate; Alkalies; Anaerobiosis; Animals; Glycolysis; Hypoxia; Lact

1996
Lactate distribution and metabolism during and after anoxia in the turtle, Chrysemys picta bellii.
    The American journal of physiology, 1996, Volume: 271, Issue:2 Pt 2

    Topics: Animals; Carbon Dioxide; Carbon Radioisotopes; Extracellular Space; Glycogen; Hypoxia; Lactic Acid;

1996
Gluconeogenesis during hypoxia in vascular smooth muscle studied by 13C-NMR.
    Physiological research, 1995, Volume: 44, Issue:4

    Topics: Animals; Carotid Arteries; Fructosediphosphates; Gluconeogenesis; Glucose; Glycolysis; Hypoxia; In V

1995
Comparison of gastric intramucosal pH measurements with oxygen supply, oxygen consumption and arterial lactate in patients with severe sepsis.
    Advances in experimental medicine and biology, 1996, Volume: 388

    Topics: Adolescent; Adult; Aged; Gastric Mucosa; Humans; Hydrogen-Ion Concentration; Hypoxia; Lactic Acid; M

1996
Effects of hypoxia on urinary organic acid and hypoxanthine excretion in fetal sheep.
    Pediatric research, 1996, Volume: 40, Issue:2

    Topics: Animals; Asphyxia Neonatorum; Blood Gas Analysis; Blood Pressure; Carboxylic Acids; Disease Models,

1996
Endogenous adenosine increases O2 utilisation efficiency in isoprenaline-stimulated canine myocardium.
    Cardiovascular research, 1996, Volume: 31, Issue:1

    Topics: Adenine; Adenosine; Adenosine Deaminase; Adrenergic beta-Agonists; Animals; Dogs; Hypoxia; Isoproter

1996
Effect of acute normobaric hypoxia on quadriceps integrated electromyogram and blood metabolites during incremental exercise to exhaustion.
    European journal of applied physiology and occupational physiology, 1996, Volume: 73, Issue:1-2

    Topics: Adult; Ammonia; Arteries; Atmospheric Pressure; Electromyography; Heart Rate; Humans; Hypoxia; Lacti

1996
Glycolysis is not responsible for the tolerance of immature renal tubules to anoxia.
    Pediatric research, 1996, Volume: 40, Issue:3

    Topics: Adenosine Triphosphate; Anaerobiosis; Animals; Evaluation Studies as Topic; Glycolysis; Hypoxia; Kid

1996
Relationship between anoxia exposure and antioxidant status in the frog Rana pipiens.
    The American journal of physiology, 1996, Volume: 271, Issue:4 Pt 2

    Topics: Animals; Antioxidants; Glutathione; Hypoxia; Lactic Acid; Lipid Peroxides; Liver; Oxidoreductases; R

1996
Lactate accumulation during moderate hypoxic hypoxia in neocortical rat brain.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1996, Volume: 16, Issue:6

    Topics: Animals; Aspartic Acid; Brain; Energy Metabolism; Female; Hypoxia; Lactic Acid; Rats; Rats, Sprague-

1996
Kinetics of oxygen consumption during maximal exercise at different muscle temperatures.
    Respiration physiology, 1995, Volume: 102, Issue:2-3

    Topics: Adult; Blood Flow Velocity; Cold Temperature; Humans; Hypoxia; Immersion; Kinetics; Lactic Acid; Mal

1995
Maximal accumulated oxygen deficit of resistance-trained men.
    Canadian journal of applied physiology = Revue canadienne de physiologie appliquee, 1996, Volume: 21, Issue:5

    Topics: Adult; Anaerobic Threshold; Anaerobiosis; Blood Gas Analysis; Body Mass Index; Exercise; Humans; Hyd

1996
Transport and metabolism of L-glutamate during oxygenation, anoxia, and reoxygenation of rat cardiac myocytes.
    The American journal of physiology, 1996, Volume: 270, Issue:5 Pt 2

    Topics: Amino Acids; Animals; Biological Transport; Energy Metabolism; Glutamic Acid; Heart; Hypoxia; Intrac

1996
Tissue hypoxia in ipsilateral and contralateral testes undergoing surgically induced maldescent.
    European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie, 1996, Volume: 6, Issue:5

    Topics: Animals; Animals, Newborn; Cryptorchidism; Hypoxanthine; Hypoxia; Lactic Acid; Male; Rats; Testis

1996
New aspects of lactate metabolism: IGF-I and insulin regulate mitochondrial function in cultured brain cells during normoxia and hypoxia.
    Developmental neuroscience, 1996, Volume: 18, Issue:5-6

    Topics: Animals; Astrocytes; Brain; Cells, Cultured; Glucose; Hypoxia; Insulin; Insulin-Like Growth Factor I

1996
Astrocyte glucose metabolism under normal and pathological conditions in vitro.
    Developmental neuroscience, 1996, Volume: 18, Issue:5-6

    Topics: Acidosis; Adenosine Triphosphate; Animals; Astrocytes; Azides; Deoxyglucose; Drug Synergism; Glucose

1996
Dynamics of myocardial adaptation to low-flow ischemia and hypoxemia.
    The American journal of physiology, 1996, Volume: 271, Issue:6 Pt 2

    Topics: Adaptation, Physiological; Animals; Coronary Circulation; Heart; Hypoxia; In Vitro Techniques; Lacti

1996
Myocardial anaerobic metabolism occurs at a critical coronary venous PO2 in pigs.
    American journal of respiratory and critical care medicine, 1997, Volume: 155, Issue:1

    Topics: Anaerobiosis; Animals; Cardiac Output; Coronary Circulation; Coronary Vessels; Hypoxia; Lactic Acid;

1997
Effect of hypoxia and carbon monoxide on muscle oxygenation during exercise.
    American journal of respiratory and critical care medicine, 1997, Volume: 155, Issue:1

    Topics: Adult; Carbon Monoxide; Carboxyhemoglobin; Humans; Hypoxia; Lactic Acid; Male; Muscle, Skeletal; Oxy

1997
Intracellular lactate controls adenosine output from dog gracilis muscle during moderate systemic hypoxia.
    The American journal of physiology, 1997, Volume: 272, Issue:1 Pt 2

    Topics: Adenosine; Animals; Dogs; Gases; Hemodynamics; Hindlimb; Hydrogen-Ion Concentration; Hypoxia; Intrac

1997
Effect of hypoxemia on tissue glycogen content and glycolytic enzyme activities in fetal sheep.
    The American journal of physiology, 1997, Volume: 272, Issue:1 Pt 2

    Topics: Animals; Blood Glucose; Cyclic AMP; Fetal Blood; Fetus; Gases; Glucose-6-Phosphatase; Glycogen; Glyc

1997
The effect of exercise on the development of respiratory depression during sustained isocapnic hypoxia in humans.
    Respiration; international review of thoracic diseases, 1997, Volume: 64, Issue:1

    Topics: Adult; Carbon Dioxide; Chemoreceptor Cells; Exercise; Humans; Hypoxia; Lactic Acid; Male; Oxygen; Re

1997
The effects of propofol on cerebral high energy metabolites, lactate, and glucose in normoxic and severely hypoxic rats.
    Life sciences, 1997, Volume: 60, Issue:16

    Topics: Adenine Nucleotides; Anesthetics, Intravenous; Animals; Cerebral Cortex; Energy Metabolism; Glucose;

1997
Balancing hypoxia and hypothermia in cold-submerged frogs.
    The Journal of experimental biology, 1997, Volume: 200, Issue:Pt 6

    Topics: Acid-Base Equilibrium; Aerobiosis; Animals; Behavior, Animal; Cold Temperature; Hydrogen-Ion Concent

1997
Chronic hypoxia, glutathione-dependent detoxication, and metabolic instability in rat small intestine.
    The American journal of physiology, 1997, Volume: 272, Issue:2 Pt 1

    Topics: Animals; Cell Survival; Chronic Disease; Fructose; Glutathione; Hypoxia; Ileum; Inactivation, Metabo

1997
1996 J.B. Wolffe Memorial Lecture. Challenging beliefs: ex Africa semper aliquid novi.
    Medicine and science in sports and exercise, 1997, Volume: 29, Issue:5

    Topics: Anaerobiosis; Dietary Carbohydrates; Exercise; Humans; Hypoxia; Lactic Acid; Mitochondria, Muscle; M

1997
Energy turnover in the normoxic and anoxic turtle heart.
    Comparative biochemistry and physiology. Part A, Physiology, 1997, Volume: 117, Issue:1

    Topics: Adenosine Triphosphate; Anaerobic Threshold; Animals; Energy Metabolism; Glycolysis; Hypoxia; Lactic

1997
On the cardioprotective effect of adenosine.
    Acta physiologica Hungarica, 1996, Volume: 84, Issue:3

    Topics: Adenosine; Adenosine Triphosphate; Animals; Glycogen; Guinea Pigs; Heart; Hypoxia; In Vitro Techniqu

1996
[Effect of a three month training period on the maximal oxygen deficiency in high level performance sprinters].
    Canadian journal of applied physiology = Revue canadienne de physiologie appliquee, 1997, Volume: 22, Issue:2

    Topics: Adult; Anaerobic Threshold; Blood Gas Analysis; Humans; Hypoxia; Lactic Acid; Oxygen; Oxygen Consump

1997
Energy metabolism in liver of anoxia-tolerant turtle species (Pseudemys scripta): a model for studying hepatic tolerance to cold hypoxia.
    Cryobiology, 1997, Volume: 35, Issue:1

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Biomarkers; Cold Te

1997
Carnitine palmitoyl-transferase enzyme inhibition protects proximal tubules during hypoxia.
    Kidney international, 1997, Volume: 52, Issue:2

    Topics: Acylation; Adenosine Triphosphate; Animals; Carnitine; Carnitine O-Palmitoyltransferase; Carrier Pro

1997
Myocardial adaptation to acute oxygen shortage. A kinetic analysis.
    Advances in experimental medicine and biology, 1997, Volume: 411

    Topics: Adaptation, Physiological; Adenosine Triphosphate; Animals; Energy Metabolism; Glycogen; Hypoxia; In

1997
Release of lactate by the lung in acute lung injury.
    Advances in experimental medicine and biology, 1997, Volume: 411

    Topics: Biological Transport, Active; Case-Control Studies; Critical Illness; Humans; Hypoxia; Lactic Acid;

1997
Effects of hemodilution and oxygen breathing on gut oxygenation in anesthetized dogs.
    Advances in experimental medicine and biology, 1997, Volume: 411

    Topics: Anesthesia; Animals; Cardiac Output; Digestive System; Dogs; Hematocrit; Hemodilution; Hypoxia; Inte

1997
The effects of low pH and CO2 on bovine corneal lactate production.
    The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc, 1997, Volume: 23, Issue:4

    Topics: Acidosis; Animals; Carbon Dioxide; Cattle; Cornea; Hydrogen-Ion Concentration; Hypoxia; Lactic Acid;

1997
Mixed venous oxygen saturation and biochemical parameters of hypoxia during progressive hypoxemia in 10- to 14-day-old piglets.
    Pediatric research, 1997, Volume: 42, Issue:6

    Topics: Animals; Disease Progression; Hypoxia; Lactic Acid; Linear Models; Oxygen; Pyruvic Acid; Swine; Vein

1997
Glia are the main source of lactate utilized by neurons for recovery of function posthypoxia.
    Brain research, 1997, Nov-07, Volume: 774, Issue:1-2

    Topics: Animals; Citrates; Electrophysiology; Hippocampus; Hypoxia; In Vitro Techniques; Lactic Acid; Male;

1997
Effects of indomethacin and polyunsaturated fatty acid diet on exercise-induced hypoxaemia in master athletes.
    European journal of applied physiology and occupational physiology, 1998, Volume: 77, Issue:1-2

    Topics: Adult; Cyclooxygenase Inhibitors; Dietary Fats, Unsaturated; Exercise; Fatty Acids, Unsaturated; Hum

1998
Lactate-induced vascular relaxation in porcine coronary arteries is mediated by Ca2+-activated K+ channels.
    Journal of molecular and cellular cardiology, 1998, Volume: 30, Issue:2

    Topics: Animals; Calcium; Coronary Vessels; Hydrogen-Ion Concentration; Hypoxia; In Vitro Techniques; Lactic

1998
Low concentrations of adenosine receptor blocker decrease protection by hypoxic preconditioning in ischemic rat hearts.
    Journal of molecular and cellular cardiology, 1998, Volume: 30, Issue:3

    Topics: Adenosine; Adenosine Triphosphate; Animals; Creatine Kinase; Hypoxia; In Vitro Techniques; Ischemic

1998
Metabolism and acid-base status during hypoxic ventilatory depression.
    The Japanese journal of physiology, 1997, Volume: 47, Issue:6

    Topics: Acid-Base Equilibrium; Analysis of Variance; Animals; Carbon Dioxide; Hypoxia; Lactic Acid; Male; Ox

1997
Cardioprotective profile of MET-88, an inhibitor of carnitine synthesis, and insulin during hypoxia in isolated perfused rat hearts.
    Fundamental & clinical pharmacology, 1998, Volume: 12, Issue:2

    Topics: Administration, Oral; Animals; Cardiovascular Agents; Carnitine; Coronary Circulation; Glucose; Glyc

1998
Effect of hyperglycemia on brain cell membrane function and energy metabolism during hypoxia-ischemia in newborn piglets.
    Brain research, 1998, Jul-06, Volume: 798, Issue:1-2

    Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Brain; Brain Ischemia; Cell Membrane; Energy Meta

1998
Asanguineous isolated hyperthermic perfusion of the liver: results of an experimental study in pigs.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1998, Volume: 147

    Topics: Animals; Hyperthermia, Induced; Hypoxia; Lactic Acid; Liver; Perfusion; Survival Rate; Swine; Transa

1998
Restoration of hypoxia-stimulated glucose uptake in GLUT4-deficient muscles by muscle-specific GLUT4 transgenic complementation.
    The Journal of biological chemistry, 1998, Aug-14, Volume: 273, Issue:33

    Topics: Adenosine Triphosphate; Animals; Deoxyglucose; Female; Genetic Complementation Test; Glucose Transpo

1998
Transcapillary transport of metaiodobenzylguanidine (MIBG) in isolated rat heart.
    Nuclear medicine and biology, 1998, Volume: 25, Issue:5

    Topics: 3-Iodobenzylguanidine; Animals; Blood Pressure; Capillary Permeability; Coronary Circulation; Female

1998
Reductions in cardiac output in hypoxic young pigs: systemic and regional perfusion and oxygen metabolism.
    Journal of applied physiology (Bethesda, Md. : 1985), 1998, Volume: 85, Issue:3

    Topics: Animals; Blood Glucose; Brain Chemistry; Cardiac Output; Glucose; Heart Rate; Hematocrit; Hemodynami

1998
Lactate and pyruvate changes in the cerebral gray and white matter during posthypoxic seizures in newborn pigs.
    Pediatric research, 1998, Volume: 44, Issue:5

    Topics: Animals; Animals, Newborn; Cerebellum; Electroencephalography; Hypoxia; Lactic Acid; Microdialysis;

1998
Proton MR spectroscopy in infants with cerebral energy deficiency due to hypoxia and metabolic disorders.
    Acta radiologica (Stockholm, Sweden : 1987), 1998, Volume: 39, Issue:6

    Topics: Aspartic Acid; Basal Ganglia; Brain; Brain Diseases, Metabolic; Child, Preschool; Follow-Up Studies;

1998
Unloaded skeletal muscle O2 uptake decreases with decreased venous PO2 at high-frequency stimulation.
    The Japanese journal of physiology, 1998, Volume: 48, Issue:5

    Topics: Animals; Diffusion; Dogs; Electric Stimulation; Hypoxia; Lactic Acid; Muscle Contraction; Muscle, Sk

1998
Effects of hypothermic hypoxia on anaerobic energy metabolism in isolated anuran livers.
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 1998, Volume: 168, Issue:8

    Topics: Adenine Nucleotides; Anaerobiosis; Animals; Body Water; Energy Metabolism; Glucose; Hypothermia; Hyp

1998
Affected enzyme activities in Alzheimer's disease are sensitive to antemortem hypoxia.
    Journal of the neurological sciences, 1998, Nov-26, Volume: 161, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Brain; Cadaver; Female; Humans; Hypoxia; L

1998
Influence of glutathione peroxidase on coronary artery responses to alterations in PO2 and H2O2.
    The American journal of physiology, 1999, Volume: 276, Issue:1 Pt 2

    Topics: Animals; Arteries; Catalase; Cattle; Coronary Vessels; Endothelium, Vascular; Glutathione Peroxidase

1999
Subzero nonfreezing storage of isolated rat hepatocytes in University of Wisconsin solution.
    Transplantation, 1999, Jan-15, Volume: 67, Issue:1

    Topics: Adenosine; Adenosine Triphosphate; Allopurinol; Animals; Cell Separation; Cryopreservation; Glutathi

1999
Arterial O2 content and tension in regulation of cardiac output and leg blood flow during exercise in humans.
    The American journal of physiology, 1999, Volume: 276, Issue:2

    Topics: Adult; Anemia; Arteries; Cardiac Output; Epinephrine; Exercise; Humans; Hypoxia; Lactic Acid; Leg; M

1999
Localised proton magnetic resonance spectroscopy of the brain after perinatal hypoxia: a preliminary report.
    Pediatric radiology, 1999, Volume: 29, Issue:3

    Topics: Aspartic Acid; Asphyxia; Brain; Choline; Creatine; Follow-Up Studies; Humans; Hypoxia; Infant, Newbo

1999
[Lactate: a marker for tissue hypoxia].
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 1999, Volume: 34, Issue:4

    Topics: Biomarkers; Humans; Hypoxia; Lactic Acid

1999
Tissue oxygenation by near-infrared spectroscopy and muscle blood flow during isometric contractions of the forearm.
    Canadian journal of applied physiology = Revue canadienne de physiologie appliquee, 1999, Volume: 24, Issue:3

    Topics: Adult; Blood Flow Velocity; Blood Pressure; Carbon Dioxide; Electromyography; Female; Forearm; Heart

1999
Effect of reduced inspired oxygen on fetal growth and maternal glucose metabolism in rat pregnancy.
    Metabolism: clinical and experimental, 1999, Volume: 48, Issue:6

    Topics: Animals; Blood Glucose; Embryonic and Fetal Development; Female; Fetus; Glucose Transporter Type 1;

1999
Leukocyte glycolysis and lactate output in animal sepsis and ex vivo human blood.
    Metabolism: clinical and experimental, 1999, Volume: 48, Issue:6

    Topics: Animals; Biomarkers; Blood Platelets; Critical Illness; Erythrocytes; Female; Glycolysis; Humans; Hy

1999
Effect of diazepam on survival of the immature pig in a confined atmosphere.
    Journal of basic and clinical physiology and pharmacology, 1999, Volume: 10, Issue:1

    Topics: Animals; Atmosphere Exposure Chambers; Blood Gas Analysis; Blood Pressure; Body Temperature; Diazepa

1999
Anemic hypoxia in moderate intracerebral hemorrhage: the alterations of cerebral hemodynamics and brain metabolism.
    Journal of the neurological sciences, 1999, Apr-01, Volume: 164, Issue:2

    Topics: Anemia; Animals; Arteries; Blood Flow Velocity; Blood Pressure; Brain; Cerebral Hemorrhage; Cerebrov

1999
Erythropoietin concentration and arterial haemoglobin saturation with supramaximal exercise.
    Journal of sports sciences, 1999, Volume: 17, Issue:6

    Topics: Adult; Erythropoietin; Exercise; Exercise Test; Humans; Hypoxia; Lactic Acid; Male; Oximetry; Oxygen

1999
Effects of intraalveolar oxygen concentration on alveolar fluid absorption and metabolism in isolated rat lungs.
    Respiration physiology, 1999, May-03, Volume: 115, Issue:3

    Topics: Adenosine Triphosphate; Animals; Bronchoalveolar Lavage Fluid; Energy Metabolism; Glucose; Glycolysi

1999
Lactate attenuates neuron specific enolase elevation in newborn rats.
    Pediatric neurology, 1999, Volume: 21, Issue:2

    Topics: Adenosine Triphosphate; Animals; Biomarkers; Brain; Brain Diseases; Hypoxia; Lactic Acid; Phosphopyr

1999
The use of extracellular lactate as an oxidative substrate in the oxygen-limited frog.
    Respiration physiology, 1999, Aug-03, Volume: 116, Issue:2-3

    Topics: Acid-Base Equilibrium; Animals; Extracellular Space; Hydrogen-Ion Concentration; Hypoxia; In Vitro T

1999
Ethanol attenuates lactate production in hypoxic postnatal day 4 rat cerebella.
    Alcohol (Fayetteville, N.Y.), 1999, Volume: 19, Issue:1

    Topics: Age Factors; Animals; Animals, Newborn; Central Nervous System Depressants; Cerebellum; Ethanol; Hyp

1999
Relationship between mixed venous oxygen saturation and markers of tissue oxygenation in progressive hypoxic hypoxia and in isovolemic anemic hypoxia in 8- to 12-day-old piglets.
    Critical care medicine, 1999, Volume: 27, Issue:9

    Topics: Anemia; Animals; Animals, Newborn; Hemoglobins; Hypoxia; Lactic Acid; Oximetry; Oxygen; Oxygen Consu

1999
Extracellular lactate and glucose alterations in the brain after head injury measured by microdialysis.
    Critical care medicine, 1999, Volume: 27, Issue:9

    Topics: Adult; Analysis of Variance; Brain Injuries; Cerebral Cortex; Cerebrovascular Circulation; Female; G

1999
Modulation of systemic hemodynamics by exogenous L-arginine in normal and bacteremic sheep.
    Critical care medicine, 1999, Volume: 27, Issue:11

    Topics: Acidosis; Animals; Arginine; Bacteremia; Blood Gas Analysis; Blood Pressure; Disease Models, Animal;

1999
[Lactate: a marker for tissue hypoxia].
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 1999, Volume: 34, Issue:11

    Topics: Humans; Hypoxia; Lactic Acid

1999
Monitoring by subcutaneous microdialysis in neurosurgical intensive care.
    Acta neurochirurgica. Supplement, 1999, Volume: 75

    Topics: Adolescent; Aged; Blood Glucose; Brain Injuries; Chromatography, High Pressure Liquid; Female; Gluta

1999
Hypothermia abolishes hypoxia-induced hyperpermeability in brain microvessel endothelial cells.
    Brain research. Molecular brain research, 1999, Dec-10, Volume: 74, Issue:1-2

    Topics: Adenosine Triphosphate; Animals; Brain; Cell Membrane Permeability; Cells, Cultured; Cold Temperatur

1999
Expression of heat shock proteins in turtle and mammal hearts: relationship to anoxia tolerance.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 278, Issue:1

    Topics: Air; Animals; Female; Heat-Shock Proteins; Hypoxia; Lactic Acid; Male; Rabbits; Rats; Rats, Sprague-

2000
What governs skeletal muscle VO2max? New evidence.
    Medicine and science in sports and exercise, 2000, Volume: 32, Issue:1

    Topics: Anaerobic Threshold; Analysis of Variance; Animals; Diffusion; Disease Models, Animal; Dogs; Exercis

2000
Effects of RGP lens extended wear on glucose-lactate metabolism and stromal swelling in the rabbit cornea.
    The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc, 2000, Volume: 26, Issue:1

    Topics: Adenosine Triphosphate; Animals; Aqueous Humor; Biomarkers; Contact Lenses, Extended-Wear; Corneal E

2000
Redox pairs, tissue hypoxia, organ dysfunction, and mortality.
    Critical care medicine, 2000, Volume: 28, Issue:1

    Topics: Humans; Hypoxia; Ketone Bodies; Lactic Acid; Multiple Organ Failure; Oxidation-Reduction; Predictive

2000
Regulation of glycogen phosphorylase and PDH during exercise in human skeletal muscle during hypoxia.
    American journal of physiology. Endocrinology and metabolism, 2000, Volume: 278, Issue:3

    Topics: Adenosine Triphosphate; Adult; Carnitine; Coenzyme A; Energy Metabolism; Exercise; Glycogen; Glycoly

2000
Hepatic and splanchnic oxygen consumption during acute hypoxemic hypoxia in anesthetized pigs.
    Critical care medicine, 2000, Volume: 28, Issue:3

    Topics: Analysis of Variance; Animals; Disease Models, Animal; Female; Hemodynamics; Hypoxia; Lactic Acid; L

2000
Age-dependent metabolic effects of repeated hypoxemia in piglets.
    Canadian journal of physiology and pharmacology, 2000, Volume: 78, Issue:4

    Topics: Aging; Animals; Behavior, Animal; Carbon Dioxide; Catecholamines; Hemodynamics; Hypoxia; Lactic Acid

2000
Acute oxygen supplementation restores markers of hepatocyte energy status and hypoxia in cirrhotic rats.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 293, Issue:2

    Topics: Animals; Biomarkers; Blood Gas Analysis; Carbon Tetrachloride Poisoning; Energy Metabolism; Hypoxia;

2000
Oxygen deficit is related to the exercise time to exhaustion at maximal aerobic speed in middle distance runners.
    Archives of physiology and biochemistry, 1999, Volume: 107, Issue:4

    Topics: Adult; Exercise; Humans; Hydrogen-Ion Concentration; Hypoxia; Lactic Acid; Male; Oxygen; Respiration

1999
Effects of hypoxia on plasma amino acids of fetal sheep.
    Amino acids, 2000, Volume: 18, Issue:2

    Topics: Amino Acids; Animals; Blood Glucose; Chromatography, Ion Exchange; Female; Hydrogen-Ion Concentratio

2000
Bone and shell contribution to lactic acid buffering of submerged turtles Chrysemys picta bellii at 3 degrees C.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 278, Issue:6

    Topics: Acid-Base Equilibrium; Adaptation, Physiological; Animals; Body Weight; Bone and Bones; Buffers; Cal

2000
Performance level and cardiopulmonary responses during a cycle-run trial.
    International journal of sports medicine, 2000, Volume: 21, Issue:4

    Topics: Adult; Analysis of Variance; Bicycling; Competitive Behavior; Exercise Test; Humans; Hypoxia; Lactic

2000
Operation Everest III: role of plasma volume expansion on VO(2)(max) during prolonged high-altitude exposure.
    Journal of applied physiology (Bethesda, Md. : 1985), 2000, Volume: 89, Issue:1

    Topics: Adult; Altitude; Altitude Sickness; Atmosphere Exposure Chambers; Body Mass Index; Heart Rate; Human

2000
Time-pattern of lactate and lactate to pyruvate ratio in the first 24 hours of intensive care emergency admissions.
    Shock (Augusta, Ga.), 2000, Volume: 14, Issue:1

    Topics: Acidosis, Lactic; APACHE; Biomarkers; Critical Care; Emergencies; Female; Finland; Glasgow Coma Scal

2000
Anoxia tolerance of con-familial tiger beetle larvae is associated with differences in energy flow and anaerobiosis.
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2000, Volume: 170, Issue:4

    Topics: Adaptation, Physiological; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; A

2000
Osmolar gap metabolic acidosis in a 60-year-old man treated for hypoxemic respiratory failure.
    Chest, 2000, Volume: 118, Issue:2

    Topics: Acidosis, Lactic; Drug Combinations; Humans; Hypnotics and Sedatives; Hypoxia; Infusions, Intravenou

2000
Interleukin-1beta alters the oxygen delivery-oxygen consumption relationship in rabbits by increasing the slope of the supply-independent line.
    Shock (Augusta, Ga.), 2000, Volume: 14, Issue:2

    Topics: Animals; Cardiac Tamponade; Female; Humans; Hypotension; Hypoxia; Interleukin-1; Lactic Acid; Models

2000
Effect of severe normocapnic hypoxia on renal function in growth-restricted newborn piglets.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 279, Issue:3

    Topics: Acidosis; Animals; Animals, Newborn; Blood Gas Analysis; Blood Glucose; Blood Pressure; Carbon Dioxi

2000
Oxygen consumption, blood lactate and inter-individual variation in the gulf killifish, Fundulus grandis, during hypoxia and recovery.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2000, Volume: 126, Issue:3

    Topics: Animals; Hypoxia; Killifishes; Lactic Acid; Oxygen Consumption

2000
Metabolic effects induced by epinephrine in Rana balcanica erythrocytes under normoxic and hypoxic conditions.
    Cell biochemistry and function, 2000, Volume: 18, Issue:3

    Topics: Adenosine Triphosphate; Adrenergic Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonis

2000
Dynamic changes in glucose and lactate in the cortex of the freely moving rat monitored using microdialysis.
    Journal of neurochemistry, 2000, Volume: 75, Issue:4

    Topics: Adrenergic beta-Antagonists; Animals; Atmosphere Exposure Chambers; Cerebral Cortex; Extracellular S

2000
Conservation of phosphorylation state of cardiac phosphofructokinase during in vitro hypothermic hypoxia.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:5

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Alkanesulfonic Acids; Animal

2000
Increased skin lactate in complex regional pain syndrome: evidence for tissue hypoxia?
    Neurology, 2000, Oct-24, Volume: 55, Issue:8

    Topics: Adult; Female; Humans; Hypoxia; Lactic Acid; Male; Microdialysis; Middle Aged; Reflex Sympathetic Dy

2000
Respiratory compensation point during incremental exercise as related to hypoxic ventilatory chemosensitivity and lactate increase in man.
    The Japanese journal of physiology, 2000, Volume: 50, Issue:4

    Topics: Acidosis, Lactic; Adult; Carbon Dioxide; Carotid Body; Female; Humans; Hypercapnia; Hypoxia; Lactic

2000
The physiology of hibernation among painted turtles: the midland painted turtle (Chrysemys picta marginata).
    Respiration physiology, 2001, Volume: 124, Issue:1

    Topics: Acid-Base Equilibrium; Acidosis; Animals; Calcium; Diving; Hematocrit; Hibernation; Hypoxia; Lactic

2001
Metabolic component of intestinal PCO(2) during dysoxia.
    Journal of applied physiology (Bethesda, Md. : 1985), 2000, Volume: 89, Issue:6

    Topics: Acid-Base Equilibrium; Animals; Carbon Dioxide; Hypoxia; In Vitro Techniques; Intestinal Mucosa; Kin

2000
Osteoblast expression of vascular endothelial growth factor is modulated by the extracellular microenvironment.
    American journal of physiology. Cell physiology, 2001, Volume: 280, Issue:1

    Topics: Acidosis, Lactic; Animals; Animals, Newborn; Cells, Cultured; Endothelial Growth Factors; Extracellu

2001
Purinergic contribution to circulatory, metabolic, and adrenergic responses to acute hypoxemia in fetal sheep.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 280, Issue:3

    Topics: Animals; Blood Glucose; Blood Pressure; Catecholamines; Epinephrine; Female; Femoral Artery; Fetal B

2001
Effect of NaHCO3 on cardiac energy metabolism and contractile function during hypoxemia.
    Critical care medicine, 2001, Volume: 29, Issue:2

    Topics: Acidosis, Lactic; Analysis of Variance; Animals; Blood Gas Analysis; Disease Models, Animal; Dogs; D

2001
Carboxyhemoglobin and lactate levels do not correlate in critically ill patients.
    American journal of therapeutics, 1999, Volume: 6, Issue:5

    Topics: Animals; Biomarkers; Blood Gas Analysis; Carboxyhemoglobin; Critical Illness; Disease Models, Animal

1999
Effect of prior high-intensity exercise on exercise-induced arterial hypoxemia in Thoroughbred horses.
    Journal of applied physiology (Bethesda, Md. : 1985), 2001, Volume: 90, Issue:6

    Topics: Animals; Arteries; Bicarbonates; Blood Gas Analysis; Blood-Air Barrier; Body Temperature; Endoscopy;

2001
Diaphragm fatigue during exercise at high altitude: the role of hypoxia and workload.
    The European respiratory journal, 2001, Volume: 17, Issue:4

    Topics: Adult; Altitude; Diaphragm; Exercise; Humans; Hypoxia; Lactic Acid; Male; Muscle Fatigue; Workload

2001
Physiological responses to supercooling and hypoxia in the hatchling painted turtle, Chrysemys picta.
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2001, Volume: 171, Issue:4

    Topics: Animals; Animals, Newborn; Body Temperature; Cold Temperature; Glucose; Glycerol; Hypoxia; Lactic Ac

2001
Blood lactate exchange and removal abilities after relative high-intensity exercise: effects of training in normoxia and hypoxia.
    European journal of applied physiology, 2001, Volume: 84, Issue:5

    Topics: Adult; Exercise; Female; Humans; Hypoxia; Lactic Acid; Longitudinal Studies; Male; Oxygen; Oxygen Co

2001
Effect of changing tumor oxygenation on glycolytic metabolism in a murine C3H mammary carcinoma assessed by in vivo nuclear magnetic resonance spectroscopy.
    Cancer research, 2001, Jul-01, Volume: 61, Issue:13

    Topics: Animals; Blood Glucose; Carbon Dioxide; Carbon Isotopes; Carbon Monoxide; Female; Glucose; Glycolysi

2001
The 'lactate paradox', evidence for a transient change in the course of acclimatization to severe hypoxia in lowlanders.
    Acta physiologica Scandinavica, 2000, Volume: 170, Issue:4

    Topics: Acclimatization; Adult; Hemoglobins; Humans; Hypoxia; Lactic Acid; Male; Mountaineering; Physical Ex

2000
Advanced gestational age and fetal lactate levels in flight.
    Aviation, space, and environmental medicine, 2001, Volume: 72, Issue:8

    Topics: Aerospace Medicine; Animals; Female; Fetus; Gestational Age; Humans; Hypoxia; Lactic Acid; Pregnancy

2001
Peak heart rate decreases with increasing severity of acute hypoxia.
    High altitude medicine & biology, 2001,Fall, Volume: 2, Issue:3

    Topics: Adaptation, Physiological; Adult; Altitude Sickness; Catecholamines; Exercise; Heart Rate; Humans; H

2001
Anoxia tolerance and anaerobic metabolism in two tropical weevil species (Coleoptera, Curculionidae).
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2001, Volume: 171, Issue:7

    Topics: Adaptation, Physiological; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; A

2001
Live high:train low increases muscle buffer capacity and submaximal cycling efficiency.
    Acta physiologica Scandinavica, 2001, Volume: 173, Issue:3

    Topics: Adaptation, Physiological; Adenosine Triphosphate; Adult; Altitude; Atmosphere Exposure Chambers; Bi

2001
Modulators of haemocyanin oxygen affinity in the hypoxia- and sulphide-tolerant Baltic isopod Saduria entomon (L.).
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2001, Volume: 171, Issue:8

    Topics: Animals; Binding, Competitive; Cations, Divalent; Crustacea; Hemocyanins; Hypoxia; Lactic Acid; Oxyg

2001
[Effects of acute hypoxia on plasma lactic acid and lactic dehydrogenase content in pilots].
    Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering, 2000, Volume: 13, Issue:6

    Topics: Adult; Aerospace Medicine; Humans; Hypoxia; L-Lactate Dehydrogenase; Lactic Acid; Male; Time Factors

2000
Beta-adrenoceptors mediate inhibition of lipolysis in adipocytes of tilapia (Oreochromis mossambicus).
    American journal of physiology. Endocrinology and metabolism, 2002, Volume: 282, Issue:2

    Topics: Adipocytes; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adren

2002
Gender differences in the endocrine and metabolic responses to hypoxic exercise.
    Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 92, Issue:2

    Topics: Adult; Blood Glucose; Cardiovascular System; Differential Threshold; Endocrine Glands; Exercise; Fem

2002
Exposure to hypoxia primes the respiratory and metabolic responses of the epaulette shark to progressive hypoxia.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2002, Volume: 131, Issue:2

    Topics: Animals; Blood Glucose; Hematocrit; Hypoxia; Lactic Acid; Oxygen; Oxygen Consumption; Sharks

2002
Measurement of interstitial lactate during hypoxia-induced dilatation in isolated pressurised porcine coronary arteries.
    The Journal of physiology, 2002, Feb-15, Volume: 539, Issue:Pt 1

    Topics: Animals; Coronary Vessels; Dichloroacetic Acid; Dose-Response Relationship, Drug; Extracellular Spac

2002
Is lactate a reliable indicator of tissue hypoxia in the neonatal period?
    Acta paediatrica (Oslo, Norway : 1992), 2002, Volume: 91, Issue:1

    Topics: Biomarkers; Female; Humans; Hypoxia; Infant, Newborn; Ischemia; Lactates; Lactic Acid; Male; Neonata

2002
Agreement between capillary and arterial lactate in the newborn.
    Acta paediatrica (Oslo, Norway : 1992), 2002, Volume: 91, Issue:1

    Topics: Biomarkers; Capillaries; Female; Humans; Hypoxia; Infant, Newborn; Intensive Care Units, Neonatal; I

2002
Changes in MCT 1, MCT 4, and LDH expression are tissue specific in rats after long-term hypobaric hypoxia.
    Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 92, Issue:4

    Topics: Acclimatization; Altitude; Animals; Atmospheric Pressure; Blotting, Western; Electron Transport Comp

2002
Hypoxia is not the sole cause of lactate production during shock.
    The Journal of trauma, 2002, Volume: 52, Issue:3

    Topics: Analysis of Variance; Animals; Epinephrine; Ethanol; Hypoxia; Lactic Acid; Male; Microdialysis; Ouab

2002
Oxygen consumption and force development in turtle and trout cardiac muscle during acidosis and high extracellular potassium.
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2002, Volume: 172, Issue:2

    Topics: Acidosis; Animals; Carbon Dioxide; Cell Respiration; Epinephrine; Heart; Hydrogen-Ion Concentration;

2002
Effects of prevailing hypoxaemia, acidaemia or hypoglycaemia upon the cardiovascular, endocrine and metabolic responses to acute hypoxaemia in the ovine fetus.
    The Journal of physiology, 2002, Apr-01, Volume: 540, Issue:Pt 1

    Topics: Acid-Base Equilibrium; Acidosis; Acute Disease; Adrenocorticotropic Hormone; Animals; Blood Gas Anal

2002
Low sodium intake does not impair renal compensation of hypoxia-induced respiratory alkalosis.
    Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 92, Issue:5

    Topics: Aldosterone; Alkalosis, Respiratory; Angiotensin II; Animals; Arteries; Atrial Natriuretic Factor; B

2002
Increased blood ammonia in hypoxia during exercise in humans.
    Journal of physiology and biochemistry, 2001, Volume: 57, Issue:4

    Topics: Adult; Altitude; Ammonia; Exercise; Humans; Hypoxia; Lactic Acid; Male; Oxygen

2001
The oxygen debt during routine cardiac surgery: illusion or reality?
    Perfusion, 2002, Volume: 17, Issue:3

    Topics: Aged; Biological Availability; Coronary Artery Bypass; Female; Humans; Hypoxia; Lactic Acid; Male; M

2002
The influence of acute hypoxia on the prediction of maximal oxygen uptake using multi-stage shuttle run test.
    The Journal of sports medicine and physical fitness, 2002, Volume: 42, Issue:2

    Topics: Adolescent; Adult; Analysis of Variance; Exercise Test; Heart Rate; Humans; Hypoxia; Lactic Acid; Ma

2002
Anti-inflammatory agent, dexamethasone, does not affect exercise-induced arterial hypoxemia in Thoroughbreds.
    Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 93, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Blood Gas Analysis; Carbon Dioxide; Dexamethasone; Female; Heart

2002
1H-NMR spectroscopy of cerebrospinal fluid of fetal sheep during hypoxia-induced acidemia and recovery.
    Pediatric research, 2002, Volume: 52, Issue:1

    Topics: 3-Hydroxybutyric Acid; Acidosis; Animals; Choline; Citric Acid; Creatinine; Energy Metabolism; Femal

2002
Chronic hypoxia: a model for cyanotic congenital heart defects.
    The Journal of thoracic and cardiovascular surgery, 2002, Volume: 124, Issue:1

    Topics: Adenosine Triphosphate; Animals; Cardiopulmonary Bypass; Chronic Disease; Cyanosis; Disease Models,

2002
Hypoxic liver injury and the ameliorating effects of fructose: the "glucose paradox" revisited.
    The American journal of physiology, 1992, Volume: 263, Issue:3 Pt 1

    Topics: Animals; Fructose; Glucose; Glycolysis; Hypoxia; Insulin; Lactates; Lactic Acid; Liver; Perfusion; R

1992
Roles of catecholamines and corticosterone during anoxia and recovery at 5 degrees C in turtles.
    The American journal of physiology, 1992, Volume: 263, Issue:4 Pt 2

    Topics: Air; Animals; Blood Glucose; Cold Temperature; Corticosterone; Epinephrine; Hypoxia; Immersion; Lact

1992
Cerebral extracellular glucose and lactate concentrations during and after moderate hypoxia in glucose- and saline-infused rats.
    Anesthesiology, 1992, Volume: 77, Issue:4

    Topics: Animals; Brain; Extracellular Space; Glucose; Hypoxia; Lactates; Lactic Acid; Male; Rats; Rats, Wist

1992
Metabolic adaptation of fetal hindlimb to severe, nonlethal hypoxia.
    The American journal of physiology, 1992, Volume: 263, Issue:5 Pt 2

    Topics: Adaptation, Physiological; Animals; Fetal Blood; Fetus; Hindlimb; Hypoxia; Lactates; Lactic Acid; Os

1992
Enzyme mechanisms for pyruvate-to-lactate flux attenuation: a study of Sherpas, Quechuas, and hummingbirds.
    International journal of sports medicine, 1992, Volume: 13 Suppl 1

    Topics: Adaptation, Physiological; Animals; Birds; China; Energy Metabolism; Exercise; Glycolysis; Humans; H

1992
Effects of sustained hypoxemia on the sheep fetus at midgestation: endocrine, cardiovascular, and biophysical responses.
    American journal of obstetrics and gynecology, 1992, Volume: 167, Issue:2

    Topics: Animals; Blood Glucose; Carbon Dioxide; Cardiovascular System; Endocrine Glands; Female; Fetal Disea

1992
Exercise-induced hypoxemia in athletes: role of inadequate hyperventilation.
    European journal of applied physiology and occupational physiology, 1992, Volume: 65, Issue:1

    Topics: Adult; Bicycling; Carbon Dioxide; Humans; Hyperventilation; Hypoxia; Lactates; Lactic Acid; Male; Ox

1992
ATP formation and energy demand in anoxic heart muscle of the rabbit.
    The American journal of physiology, 1992, Volume: 263, Issue:2 Pt 2

    Topics: Adenosine Triphosphate; Animals; Electric Stimulation; Energy Metabolism; Glucose; Hypoxia; In Vitro

1992
Hypoxia induces glucose transporter expression in endothelial cells.
    The American journal of physiology, 1992, Volume: 263, Issue:2 Pt 1

    Topics: Animals; Cell Survival; Cells, Cultured; Creatine Kinase; Endothelium, Vascular; Glucose; Hypoxia; L

1992
Right and left ventricular function in fetal sheep exposed to long-term high-altitude hypoxemia.
    The American journal of physiology, 1992, Volume: 262, Issue:2 Pt 2

    Topics: Altitude; Animals; Cardiac Output; Catecholamines; Fetal Diseases; Fetal Heart; Gases; Hemodynamics;

1992
Postanoxic oxidative injury in rat hepatocytes: lactate-dependent protection against tert-butylhydroperoxide.
    Free radical biology & medicine, 1992, Volume: 12, Issue:3

    Topics: Animals; Free Radicals; Hypoxia; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Liver; Male; NAD; O

1992
Effect of dichloroacetate on mechanical performance and metabolism of compromised diaphragm muscle.
    Journal of applied physiology (Bethesda, Md. : 1985), 1992, Volume: 72, Issue:3

    Topics: Animals; Diaphragm; Dichloroacetic Acid; Electric Stimulation; Glucose; Hypoxia; In Vitro Techniques

1992
[Metabolic factors of vasomotor regulation of the inner retina].
    Klinische Monatsblatter fur Augenheilkunde, 1992, Volume: 200, Issue:5

    Topics: Animals; Blood-Retinal Barrier; Energy Metabolism; Hypoxia; Lactates; Lactic Acid; Retinal Vessels;

1992
Oxygen transport during anemic hypoxia in pigs: effects of digoxin on metabolism.
    The American journal of physiology, 1992, Volume: 263, Issue:1 Pt 2

    Topics: Anemia; Animals; Biological Availability; Biological Transport; Catecholamines; Digoxin; Hematocrit;

1992
Effects of hypoxia on the contractions and lactate release induced by high-K+, ouabain and epinephrine in guinea-pig aorta.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1991, Volume: 99, Issue:3

    Topics: Anaerobiosis; Animals; Aorta, Thoracic; Calcium; Epinephrine; Extracellular Space; Guinea Pigs; Hypo

1991
Low oxygen delivery produced by anemia, hypoxia, and low cardiac output.
    The Journal of surgical research, 1991, Volume: 51, Issue:5

    Topics: Anemia; Animals; Cardiac Output, Low; Dogs; Hypoxia; Lactates; Lactic Acid; Oxygen Consumption; Ther

1991
Effect of hypoxia on cerebral metabolites measured by proton nuclear magnetic resonance spectroscopy in rats.
    Stroke, 1991, Volume: 22, Issue:1

    Topics: Animals; Aspartic Acid; Brain; Hyperglycemia; Hypoglycemia; Hypoxia; Lactates; Lactic Acid; Magnetic

1991
Differences in glycolytic capacity and hypoxia tolerance between hepatoma cells and hepatocytes.
    Hepatology (Baltimore, Md.), 1991, Volume: 13, Issue:2

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Anaerobiosis; Animals; Carci

1991
Skeletal muscle metabolism and work capacity: a 31P-NMR study of Andean natives and lowlanders.
    Journal of applied physiology (Bethesda, Md. : 1985), 1991, Volume: 70, Issue:5

    Topics: Acclimatization; Adenosine Triphosphate; Adult; Altitude; Energy Metabolism; Humans; Hypoxia; Lactat

1991
31P-NMR study of normoxic and anoxic perfused turtle heart during graded CO2 and lactic acidosis.
    The American journal of physiology, 1991, Volume: 260, Issue:6 Pt 2

    Topics: Acidosis, Lactic; Adenosine Triphosphate; Animals; Carbon Dioxide; Female; Heart; Heart Rate; Hydrog

1991
DNA synthesis is reduced in selected fetal tissues during prolonged hypoxemia.
    The American journal of physiology, 1991, Volume: 261, Issue:2 Pt 2

    Topics: Adrenal Glands; Animals; Blood Glucose; Body Weight; Carbon Dioxide; DNA; Female; Fetus; Hydrogen-Io

1991
Vascular lactic acid infusions do not alter the incidence of fetal breathing movements or their inhibition by acute hypoxemia.
    Pediatric research, 1991, Volume: 29, Issue:5

    Topics: Acidosis, Lactic; Animals; Blood Glucose; Blood Pressure; Carbon Dioxide; Female; Heart Rate; Hypoxi

1991
The energy requirements for the basal efflux of 3H-noradrenaline from sympathetically innervated organs.
    Naunyn-Schmiedeberg's archives of pharmacology, 1991, Volume: 344, Issue:3

    Topics: Animals; Atrial Function; Biological Transport; Calcium; Catechol O-Methyltransferase Inhibitors; De

1991
Metabolic and developmental responses of the calf to a chronic hypoxic episode in the immediate newborn period.
    Advances in experimental medicine and biology, 1990, Volume: 277

    Topics: Animals; Animals, Newborn; Bicarbonates; Blood Glucose; Carbon Dioxide; Cattle; Hydrogen-Ion Concent

1990
Shift of anaerobic to aerobic metabolism in the rats acclimatized to hypoxia.
    Comparative biochemistry and physiology. A, Comparative physiology, 1990, Volume: 97, Issue:3

    Topics: Acclimatization; Altitude; Animals; Energy Metabolism; Glycolysis; Hypoxia; Ketone Bodies; Lactates;

1990
Hepatic oxygen and lactate extraction during stagnant hypoxia.
    Journal of applied physiology (Bethesda, Md. : 1985), 1991, Volume: 70, Issue:1

    Topics: Animals; Dogs; Hemodynamics; Hypoxia; In Vitro Techniques; Lactates; Lactic Acid; Liver; Male; Oxyge

1991
Protection of ischaemic synaptosomes from calcium overload by addition of exogenous lactate.
    Journal of neurochemistry, 1991, Volume: 57, Issue:1

    Topics: Acetylcholine; Animals; Brain Ischemia; Calcium; Hydrogen-Ion Concentration; Hypoxia; Lactates; Lact

1991
Metabolic and work efficiencies during exercise in Andean natives.
    Journal of applied physiology (Bethesda, Md. : 1985), 1991, Volume: 70, Issue:4

    Topics: Acclimatization; Adenosine Triphosphate; Adult; Altitude; Blood Glucose; Body Water; Energy Metaboli

1991
Lactate utilization by neonatal rat liver in vitro.
    Biochemical Society transactions, 1990, Volume: 18, Issue:6

    Topics: Animals; Animals, Newborn; Female; Hypoxia; In Vitro Techniques; Lactates; Lactic Acid; Liver; Pregn

1990
Influence of phospholipid polyunsatured fatty acid composition on some metabolic disorders induced in rat cardiomyocytes by hypoxia and reoxygenation.
    Journal of molecular and cellular cardiology, 1990, Volume: 22, Issue:10

    Topics: Adenine Nucleotides; Animals; Cells, Cultured; Energy Metabolism; Fatty Acids, Unsaturated; Hypoxia;

1990
Epicardial oxygen tensions during changes in arterial PO2 in pigs.
    Advances in experimental medicine and biology, 1990, Volume: 277

    Topics: Animals; Hemodynamics; Hypoxia; Lactates; Lactic Acid; Myocardium; Oxygen; Swine

1990
Hypoxia tolerance of coronary endothelial cells.
    Advances in experimental medicine and biology, 1990, Volume: 277

    Topics: Adenine Nucleotides; Animals; Cells, Cultured; Endothelium, Vascular; Energy Metabolism; Glycolysis;

1990
Aerobic glycolysis in the retina of the crab Ocypode ryderi.
    Advances in experimental medicine and biology, 1990, Volume: 277

    Topics: Aerobiosis; Animals; Brachyura; Extracellular Space; Glycolysis; Hydrogen-Ion Concentration; Hypoxia

1990
Acid-base characteristics of steady-state exercise in rats adapted to simulated altitude.
    Advances in experimental medicine and biology, 1990, Volume: 277

    Topics: Acclimatization; Acid-Base Equilibrium; Altitude; Animals; Hemoglobins; Hydrogen-Ion Concentration;

1990
O2 supply dependency in patients without hyperlactemia.
    Advances in experimental medicine and biology, 1990, Volume: 277

    Topics: Cardiac Output; Critical Care; Dobutamine; Humans; Hypoxia; Lactates; Lactic Acid; Norepinephrine; O

1990
[Behavior of various enzyme activities during high blood lactate and pyruvate levels in albino rats reared in a normobaric hypoxic atmosphere for 1 or 2 generations].
    Bollettino della Societa italiana di biologia sperimentale, 1990, Volume: 66, Issue:12

    Topics: Acid-Base Equilibrium; Adaptation, Physiological; Animals; Atmosphere Exposure Chambers; Creatine Ki

1990
Importance of fatty acid oxidation in the neonatal pig heart with hypoxia and reoxygenation.
    Journal of developmental physiology, 1990, Volume: 14, Issue:5

    Topics: Animals; Animals, Newborn; Blood Pressure; Carbon Dioxide; Fatty Acids; Heart; Hypoxia; In Vitro Tec

1990
Influence of glucose and insulin on the exaggerated diastolic and systolic dysfunction of hypertrophied rat hearts during hypoxia.
    Circulation research, 1990, Volume: 66, Issue:2

    Topics: Animals; Cardiomegaly; Diastole; Glucose; Heart; Hypoxia; Insulin; Lactates; Lactic Acid; Male; Osmo

1990
Increased ischemic injury but decreased hypoxic injury in hypertrophied rat hearts.
    Circulation research, 1990, Volume: 67, Issue:4

    Topics: Adenosine Triphosphate; Animals; Aorta; Cardiomegaly; Constriction; Coronary Disease; Glycogen; Hear

1990
Responses of harbor seal and pig heart to progressive and acute hypoxia.
    The American journal of physiology, 1990, Volume: 259, Issue:4 Pt 2

    Topics: Acute Disease; Animals; Energy Metabolism; Heart; Hemodynamics; Hemoglobins; Hydrogen-Ion Concentrat

1990
Posthypoxic glucose supplement reduces hypoxic-ischemic brain damage in the neonatal rat.
    Annals of neurology, 1990, Volume: 28, Issue:2

    Topics: Age Factors; Animals; Animals, Newborn; Brain; Brain Chemistry; Brain Ischemia; Cerebral Cortex; Cer

1990
Depressed gluconeogenesis and ureogenesis in isolated hepatocytes after intermittent hypoxia in rats.
    The International journal of biochemistry, 1990, Volume: 22, Issue:11

    Topics: Adenosine Triphosphate; Animals; Gluconeogenesis; Hypoxia; In Vitro Techniques; Lactates; Lactic Aci

1990
Increased lactate appearance and reduced clearance during hypoxia in dogs.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1990, Volume: 22, Issue:9

    Topics: Animals; Blood Pressure; Dogs; Glucose; Hypoxia; Lactates; Lactic Acid; Metabolic Clearance Rate; Ti

1990
Brain pH in acute isocapnic metabolic acidosis and hypoxia: a 31P-nuclear magnetic resonance study.
    The American journal of physiology, 1990, Volume: 258, Issue:1 Pt 2

    Topics: Acid-Base Imbalance; Acidosis; Animals; Brain; Hydrochloric Acid; Hydrogen; Hydrogen-Ion Concentrati

1990
Attenuation of vasopressin-mediated coronary constriction and myocardial depression in the hypoxic heart.
    Circulation research, 1990, Volume: 66, Issue:3

    Topics: Animals; Arginine Vasopressin; Cardiomyopathies; Coronary Circulation; Coronary Vessels; Heart; Hypo

1990
Involvement of lactic acidosis in anoxia-induced perturbations of synaptosomal function.
    Journal of neurochemistry, 1990, Volume: 55, Issue:1

    Topics: Acidosis, Lactic; Animals; Glucose; Hypoxia; Lactates; Lactic Acid; Male; Rats; Rats, Inbred Strains

1990
Effects of hypoxia on high-energy phosphagen content, energy metabolism and isometric force in guinea-pig taenia caeci.
    The Journal of physiology, 1990, Volume: 424

    Topics: Adenine Nucleotides; Aerobiosis; Animals; Calcium; Carbachol; Diltiazem; Energy Metabolism; Guinea P

1990
Effect of probenecid on cerebral and cisternal cerebrospinal fluid lactate content.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1987, Volume: 7, Issue:1

    Topics: Animals; Brain; Cisterna Magna; Energy Metabolism; Glucose; Homovanillic Acid; Hydroxyindoleacetic A

1987
Relationship of myocardial metabolism and coronary flow: dependence on extracellular calcium.
    The American journal of physiology, 1987, Volume: 253, Issue:5 Pt 2

    Topics: Adenosine Triphosphate; Amobarbital; Animals; Calcium; Calcium Channel Blockers; Coronary Circulatio

1987
The effects of 4-pentenoic and pentanoic acid on the hypoxic rat atria.
    Archives internationales de physiologie et de biochimie, 1989, Volume: 97, Issue:5

    Topics: Animals; Fasting; Fatty Acids, Monounsaturated; Female; Heart Atria; Hypoxia; In Vitro Techniques; L

1989
Reduced systolic blood pressure elevations during maximum exercise at simulated altitudes.
    Aviation, space, and environmental medicine, 1989, Volume: 60, Issue:11

    Topics: Adult; Altitude; Atmosphere Exposure Chambers; Blood Pressure; Catecholamines; Exercise; Female; Hum

1989
Delayed neurologic deterioration following anoxia: brain mitochondrial and metabolic correlates.
    Journal of neurochemistry, 1989, Volume: 52, Issue:5

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Blood Glucose; Brain; Carbon Dioxide; Cats;

1989
The effect of etomidate pretreatment on cerebral high energy metabolites, lactate, and glucose during severe hypoxia in the rat.
    Anesthesiology, 1989, Volume: 71, Issue:3

    Topics: Animals; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Energy Metabolism; Etomidate; Glu

1989
Decreased exercise muscle lactate release after high altitude acclimatization.
    Journal of applied physiology (Bethesda, Md. : 1985), 1989, Volume: 67, Issue:4

    Topics: Acclimatization; Adult; Altitude; Exercise; Femoral Artery; Humans; Hypoxia; Iliac Vein; Lactates; L

1989
[Comparative effects of dichloroacetate and sodium bicarbonate on plasma lactic acid levels in experimentally produced hypoxia].
    Masui. The Japanese journal of anesthesiology, 1987, Volume: 36, Issue:7

    Topics: Acetates; Acidosis, Lactic; Animals; Bicarbonates; Dichloroacetic Acid; Dogs; Hemodynamics; Hypoxia;

1987
Improved hemodynamic function during hypoxia with Carbicarb, a new agent for the management of acidosis.
    Circulation, 1988, Volume: 77, Issue:1

    Topics: Acidosis, Lactic; Animals; Bicarbonates; Blood Gas Analysis; Carbonates; Cardiac Output; Dogs; Drug

1988
Plasma adrenocorticotrophin and cortisol responses to acute hypoxia at rest and during exercise.
    European journal of applied physiology and occupational physiology, 1988, Volume: 57, Issue:1

    Topics: Adrenocorticotropic Hormone; Adult; Heart Rate; Humans; Hydrocortisone; Hypoxia; Lactates; Lactic Ac

1988
The role of the adrenal medulla and peripheral sympathetic nerves in the physiological responses of the fetal sheep to hypoxia.
    Journal of developmental physiology, 1988, Volume: 10, Issue:1

    Topics: Adrenal Medulla; Adrenocorticotropic Hormone; Animals; Blood Gas Analysis; Blood Glucose; Blood Pres

1988
Stimulation of anaerobic metabolism in rats at high altitude hypoxia--adrenergic effects dependent on dietary states.
    Comparative biochemistry and physiology. B, Comparative biochemistry, 1987, Volume: 88, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Altitude Sickness; Anaerobiosis; Animals;

1987
Experimental chronic hypoxic neuropathy: relevance to diabetic neuropathy.
    The American journal of physiology, 1986, Volume: 250, Issue:1 Pt 1

    Topics: Animals; Diabetic Neuropathies; Disease Models, Animal; Electrophysiology; Glycated Hemoglobin; Hexo

1986
Role of adrenergic-dependent H+ release from red cells in acidosis induced by hypoxia in trout.
    The American journal of physiology, 1987, Volume: 252, Issue:2 Pt 2

    Topics: Acidosis; Animals; Erythrocytes; Hemoglobins; Hydrogen; Hydrogen-Ion Concentration; Hypoxia; Kinetic

1987
Pyruvate attenuation of hypoxia damage in isolated working guinea-pig heart.
    Journal of molecular and cellular cardiology, 1986, Volume: 18, Issue:4

    Topics: Animals; Carbon Dioxide; Cardiomyopathies; Deoxyglucose; Fatty Acids; Glucose; Guinea Pigs; Heart; H

1986
CO2 sensitivity of cat phrenic neurogram during hypoxic respiratory depression.
    Journal of applied physiology (Bethesda, Md. : 1985), 1988, Volume: 65, Issue:2

    Topics: Animals; Carbon Dioxide; Cats; Dichloroacetic Acid; Hypoxia; Lactates; Lactic Acid; Male; Phrenic Ne

1988
Bioenergetics of rabbit skeletal muscle during hypoxemia and ischemia.
    Journal of applied physiology (Bethesda, Md. : 1985), 1988, Volume: 65, Issue:2

    Topics: Adenosine Triphosphate; Animals; Blood Glucose; Blood Pressure; Energy Metabolism; Hydrogen-Ion Conc

1988
Limitation of maximal O2 uptake and performance by acute hypoxia in dog muscle in situ.
    Journal of applied physiology (Bethesda, Md. : 1985), 1988, Volume: 65, Issue:2

    Topics: Acid-Base Equilibrium; Animals; Dogs; Female; Hindlimb; Hydrogen-Ion Concentration; Hypoxia; Lactate

1988
The influence of fentanyl upon cerebral high-energy metabolites, lactate, and glucose during severe hypoxia in the rat.
    Anesthesiology, 1988, Volume: 69, Issue:4

    Topics: Adenosine Triphosphate; Animals; Brain; Electroencephalography; Energy Metabolism; Fentanyl; Glucose

1988
Concentration of hypoxanthine in both cerebrospinal fluid and brain tissue increases under intensive hypoxia only.
    Biology of the neonate, 1988, Volume: 54, Issue:4

    Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Blood Glucose; Brain; Glycogen; Hypoxanthine; Hyp

1988
Effects of acute hypoxia and reoxygenation in a blood-perfused neonatal heart model.
    Circulation, 1988, Volume: 78, Issue:5 Pt 2

    Topics: Acute Disease; Animals; Animals, Newborn; Blood; Energy Metabolism; Heart; Hypoxia; Lactates; Lactic

1988
Role of brain lactic acidosis in hypoxic depression of respiration.
    Journal of applied physiology (Bethesda, Md. : 1985), 1988, Volume: 65, Issue:3

    Topics: Acidosis, Lactic; Animals; Brain; Carbon Monoxide; Cats; Chemoreceptor Cells; Denervation; Dichloroa

1988
Evidence in vivo that most of the intraluminally absorbed glucose is absorbed intact into the portal vein and not metabolized to lactate.
    The Biochemical journal, 1988, Sep-15, Volume: 254, Issue:3

    Topics: Absorption; Aerobiosis; Animals; Aorta; Blood Glucose; Glucose; Hypoxia; Lactates; Lactic Acid; Male

1988
Change in plasma amino acid concentrations during breath-hold diving at high altitude.
    Clinical physiology and biochemistry, 1988, Volume: 6, Issue:6

    Topics: Adult; Altitude; Amino Acids; Anaerobiosis; Dietary Proteins; Diving; Humans; Hypoxia; Lactates; Lac

1988
Fluid-electrolyte shift and renin-aldosterone responses to exercise under hypoxia.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1987, Volume: 19, Issue:7

    Topics: Adult; Aldosterone; Catecholamines; Humans; Hypoxia; Lactates; Lactic Acid; Male; Oxygen Consumption

1987
Synergistic effects of hypoxia and fasting on harmol elimination in the isolated perfused rat liver.
    Biochemical pharmacology, 1988, Apr-01, Volume: 37, Issue:7

    Topics: Alkaloids; Animals; Fasting; Glucose; Harmine; Hypoxia; In Vitro Techniques; Lactates; Lactic Acid;

1988
Uptake of exogenous substrates during hypoxia in fetal lambs.
    The American journal of physiology, 1988, Volume: 254, Issue:5 Pt 1

    Topics: Algorithms; Animals; Blood Glucose; Female; Fetus; Hypoxia; Lactates; Lactic Acid; Maternal-Fetal Ex

1988
Relating cerebral ischemia and hypoxia to insult intensity.
    Journal of neurochemistry, 1988, Volume: 50, Issue:6

    Topics: Adenine Nucleotides; Animals; Brain; Cerebrovascular Circulation; Creatine; Dogs; Glucose; Glycogen;

1988
Hypoxanthine and lactate concentrations in lambs during hypoxic and stagnant hypoxia.
    The American journal of physiology, 1988, Volume: 255, Issue:1 Pt 2

    Topics: Algorithms; Animals; Cardiac Output; Hypoxanthine; Hypoxanthines; Hypoxia; Lactates; Lactic Acid; Ox

1988
The effect of mild hypoxemia maintained for twenty-four hours on maternal and fetal glucose, lactate, cortisol, and arginine vasopressin in pregnant sheep at 122 to 139 days' gestation.
    American journal of obstetrics and gynecology, 1987, Volume: 157, Issue:6

    Topics: Animals; Arginine Vasopressin; Blood Glucose; Female; Fetal Blood; Fetal Diseases; Gestational Age;

1987
Relationship between myocardial CK release, high energy phosphate metabolism and ultrastructure as effect of anoxia on isolated rat heart.
    Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao, 1987, Volume: 2, Issue:3

    Topics: Animals; Coronary Circulation; Creatine Kinase; Heart; Hypoxia; In Vitro Techniques; Lactates; Lacti

1987
Effect of hypoxia on lactate variables during exercise.
    Journal of human ergology, 1987, Volume: 16, Issue:2

    Topics: Adult; Anaerobiosis; Energy Metabolism; Exercise Test; Humans; Hypoxia; Lactates; Lactic Acid

1987
Metabolic and endocrine responses to graded exercise under acute hypoxia.
    European journal of applied physiology and occupational physiology, 1986, Volume: 55, Issue:3

    Topics: Adult; Androstenedione; Blood Glucose; Energy Metabolism; Exercise Test; Fatty Acids, Nonesterified;

1986
[Effect of dichloroacetate on plasma lactic acid in experimentally produced hypoxia].
    Masui. The Japanese journal of anesthesiology, 1986, Volume: 35, Issue:12

    Topics: Acetates; Acidosis, Lactic; Animals; Dichloroacetic Acid; Dogs; Hemodynamics; Hypoxia; Lactates; Lac

1986
Measurement of glucose and 2-deoxy-2-[18F]fluoro-D-glucose transport and phosphorylation rates in myocardium using dual-tracer kinetic experiments.
    FEBS letters, 1987, May-25, Volume: 216, Issue:1

    Topics: Animals; Biological Transport; Deoxy Sugars; Deoxyglucose; Fluorodeoxyglucose F18; Glucose; Heart Se

1987
Glycolytic activity and enhancement of serotonin uptake by endothelial cells exposed to hypoxia/anoxia.
    Circulation research, 1987, Volume: 60, Issue:5

    Topics: Adenosine Triphosphate; Animals; Cattle; Cell Division; Cells, Cultured; Endothelium; Glycolysis; Hy

1987
Effects of components of ischemia and metabolic inhibition on delayed afterdepolarizations in guinea pig papillary muscle.
    Circulation research, 1987, Volume: 61, Issue:2

    Topics: Acidosis; Action Potentials; Animals; Coronary Disease; Cyanides; Deoxyglucose; Guinea Pigs; Heart C

1987
Pathophysiology of type A hypoxic lactic acidosis in dogs.
    The American journal of physiology, 1987, Volume: 253, Issue:3 Pt 1

    Topics: Acid-Base Equilibrium; Acidosis; Animals; Dogs; Hemodynamics; Hypoxia; Lactates; Lactic Acid; Oxygen

1987
Simultaneous 31P- and 1H-nuclear magnetic resonance studies of hypoxia and ischemia in the cat brain.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1987, Volume: 7, Issue:5

    Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Cats; Electroencephalography; Hydrogen; Hypo

1987
Oxygen transport and metabolism in the conscious lamb: the effects of hypoxemia.
    Pediatric research, 1987, Volume: 22, Issue:2

    Topics: Age Factors; Animals; Animals, Newborn; Biological Transport, Active; Hypoxia; Lactates; Lactic Acid

1987
Role of adenosine in mediating the coronary vasodilative response to acute hypoxia.
    Cardiovascular research, 1987, Volume: 21, Issue:2

    Topics: Acute Disease; Adenosine; Adenosine Deaminase; Animals; Coronary Circulation; Coronary Vessels; Hemo

1987
Skeletal muscle energetics, acid-base equilibrium and lactate metabolism in patients with severe hypercapnia and hypoxemia.
    Chest, 1987, Volume: 92, Issue:5

    Topics: Acid-Base Equilibrium; Acute Disease; Adenosine Triphosphate; Aged; Energy Metabolism; Female; Human

1987
[Effects of ginsenosides on myocardial lactic acid, cyclic nucleotides and ultrastructural myocardial changes in anoxia in mice].
    Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine, 1987, Volume: 7, Issue:6

    Topics: Animals; Brain Chemistry; Ginsenosides; Hypoxia; Lactates; Lactic Acid; Male; Mice; Mitochondria, He

1987
Time course of muscular blood metabolites during forearm rhythmic exercise in hypoxia.
    Journal of applied physiology (Bethesda, Md. : 1985), 1986, Volume: 60, Issue:4

    Topics: Adult; Altitude Sickness; Hemoglobins; Humans; Hydrogen-Ion Concentration; Hypoxia; Lactates; Lactic

1986
Effects of exercise in normoxia and acute hypoxia on respiratory muscle metabolites.
    Journal of applied physiology (Bethesda, Md. : 1985), 1986, Volume: 60, Issue:4

    Topics: Animals; Diaphragm; Glycogen; Hypoxia; Intercostal Muscles; Lactates; Lactic Acid; Male; Muscle, Smo

1986
Cardiovascular effects of d-tubocurarine and pancuronium in newborn lambs during normoxia and hypoxia.
    Pediatric research, 1986, Volume: 20, Issue:3

    Topics: Animals; Animals, Newborn; Blood Gas Analysis; Blood Pressure; Cardiac Output; Cardiovascular System

1986
Changes in metabolite levels and morphology of teleost ventricular myocytes due to hypoxia, ischaemia, and metabolic inhibitors.
    Cytobios, 1986, Volume: 45, Issue:181

    Topics: Adenosine Triphosphate; Animals; Fishes; Heart Ventricles; Humans; Hypoxia; Ischemia; Lactates; Lact

1986
[Concentration of lactic acid in the blood and erythropoiesis during exposure to hypoxia].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1986, Volume: 72, Issue:5

    Topics: Acclimatization; Altitude; Animals; Erythropoiesis; Hemoglobins; Hemorrhage; Hypoxia; Lactates; Lact

1986
Substrates induce hypoxic injury to medullary thick limbs of isolated rat kidneys.
    The American journal of physiology, 1986, Volume: 251, Issue:4 Pt 2

    Topics: Animals; Glomerular Filtration Rate; Hypoxia; In Vitro Techniques; Kidney Diseases; Kidney Tubules;

1986
Energy deficits in hepatocytes isolated from phenobarbital-treated or fasted rats and briefly exposed to halothane and hypoxia in vitro.
    Anesthesiology, 1986, Volume: 65, Issue:4

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Analysis of Variance; Animals; Energy Metabolism; Fas

1986
Effects of in vitro anoxia and low pH on acetylcholine release by rat brain synaptosomes.
    Journal of neurochemistry, 1987, Volume: 48, Issue:4

    Topics: Acetylcholine; Animals; Brain; Calcium; Choline; Hydrogen-Ion Concentration; Hypoxia; In Vitro Techn

1987
Lactic acidosis in fulminant hepatic failure. Some aspects of pathogenesis and prognosis.
    Journal of hepatology, 1985, Volume: 1, Issue:4

    Topics: Acidosis; Blood Pressure; Carbon Dioxide; Female; Humans; Hypoxia; Lactates; Lactic Acid; Liver Dise

1985
Functional compartmentation of glycolytic versus oxidative metabolism in isolated rabbit heart.
    The Journal of clinical investigation, 1985, Volume: 75, Issue:2

    Topics: Animals; Azides; Dinitrophenols; Glycolysis; Heart; Hypoxia; In Vitro Techniques; Iodoacetates; Iodo

1985
[Blood lactate in chronic obstructive pulmonary disease with chronic cor pulmonale].
    Zhonghua nei ke za zhi, 1985, Volume: 24, Issue:1

    Topics: Aged; Female; Humans; Hypoxia; Lactates; Lactic Acid; Lung Diseases, Obstructive; Male; Middle Aged;

1985
Effect of hypoxia on oxidative and reductive pathways of omeprazole metabolism by the isolated perfused rat liver.
    Biochemical pharmacology, 1985, Apr-15, Volume: 34, Issue:8

    Topics: Animals; Benzimidazoles; Hypoxia; Lactates; Lactic Acid; Liver; Male; Omeprazole; Oxidation-Reductio

1985
The concentration of hypoxanthine and lactate in the blood of healthy and hypoxic newborns.
    Journal of perinatal medicine, 1985, Volume: 13, Issue:1

    Topics: Acid-Base Equilibrium; Apgar Score; Asphyxia Neonatorum; Humans; Hypoxanthine; Hypoxanthines; Hypoxi

1985
[Relation between glycohemoglobin, hypoxia parameters and diabetic microangiopathy].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1985, Apr-15, Volume: 40, Issue:8

    Topics: 2,3-Diphosphoglycerate; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diabetic Re

1985
Efflux of metabolized and nonmetabolized fatty acid from canine myocardium. Implications for quantifying myocardial metabolism tomographically.
    Circulation research, 1985, Volume: 57, Issue:2

    Topics: Animals; Dogs; Fatty Acids; Hemodynamics; Hypoxia; Kinetics; Lactates; Lactic Acid; Mathematics; Myo

1985
[Effect of short-term hypoxia on body temperature and lactic acid in the blood of the mouse].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1985, Volume: 71, Issue:10

    Topics: Adaptation, Physiological; Altitude; Animals; Body Temperature; Female; Hypoxia; Lactates; Lactic Ac

1985
Metabolic responses of the kidney in fetal sheep: effect of acute and spontaneous hypoxemia.
    The American journal of physiology, 1985, Volume: 249, Issue:6 Pt 2

    Topics: Animals; Blood Gas Analysis; Blood Glucose; Carbohydrate Metabolism; Catheters, Indwelling; Female;

1985
Response of the isolated heart to carbon monoxide and nitrogen anoxia.
    Toxicology and applied pharmacology, 1985, Volume: 81, Issue:3 Pt 1

    Topics: Animals; Carbon Monoxide; Electric Stimulation; Glycogen; Heart; Heart Rate; Hypoxia; Lactates; Lact

1985
[Gas exchange and metabolic functions of the lungs in endotoxic shock].
    Vestnik khirurgii imeni I. I. Grekova, 1985, Volume: 135, Issue:10

    Topics: Acidosis, Respiratory; Animals; Dogs; Female; Hydrogen-Ion Concentration; Hypoxia; Lactates; Lactic

1985