lactic acid has been researched along with Anoxemia in 912 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Excerpt | Relevance | Reference |
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"The purpose of the present investigation was to determine the independent effects of hypoxia and physical exercise on peripheral cholecystokinin (CCK) metabolism in humans." | 9.09 | Physical exercise and normobaric hypoxia: independent modulators of peripheral cholecystokinin metabolism in man. ( Bailey, DM; Calam, J; Castell, LM; Davies, B; Newsholme, EA, 2001) |
"In this study the authors examine the effects of acute hypoxia due to extracorporeal circulation (ECC) and the role played by L-carnitine treatment on some plasmatic metabolites linked to glycolytic cellular metabolism." | 9.07 | Metabolic aspects of acute tissue hypoxia during extracorporeal circulation and their modification induced by L-carnitine treatment. ( Cogliatti, A; Corbucci, GG; Menichetti, A; Nicoli, P; Ruvolo, C, 1992) |
"L-lactic acidosis (L-LA) is the most common cause of metabolic acidosis in the critical care setting, which has been associated with a large increase in mortality." | 9.05 | L-lactic acidosis: pathophysiology, classification, and causes; emphasis on biochemical and metabolic basis. ( Halperin, ML; Kamel, KS; Oh, MS, 2020) |
"This study suggests that caffeic acid inhibits PHD2 enzyme activity which then activates the hypoxia-associated transcription factor HIF leading to a neuroprotective effect against hypoxia." | 8.12 | The novel prolyl hydroxylase-2 inhibitor caffeic acid upregulates hypoxia inducible factor and protects against hypoxia. ( Diao, A; Guo, B; Guo, Z; Hao, L; Li, L; Li, Y; Liu, Z; Yang, Y; Zhao, Q, 2022) |
" Initial severe acidosis consisted of acute respiratory acidosis from ventilation-perfusion mismatch and acute metabolic acidosis resulting from bronchospasm and hypoxia-related lactic acidosis, respectively." | 8.02 | Salbutamol-induced lactic acidosis in status asthmaticus survivor. ( Boonkaya, S; Phoophiboon, V; Singhagowinta, P; Sriprasart, T, 2021) |
"The present study is an attempt to leverage therapeutic benefits of curcumin in pulmonary hypertension by encapsulating it in biodegradable poly(lactide-co-glycolic) acid nanoparticles." | 7.78 | Tissue localization of nanoparticles is altered due to hypoxia resulting in poor efficacy of curcumin nanoparticles in pulmonary hypertension. ( Devadasu, VR; Ravi Kumar, MN; Wadsworth, RM, 2012) |
" Two important determinants in this environment are hypoxia and lactic acidosis." | 7.74 | The genomic analysis of lactic acidosis and acidosis response in human cancers. ( Chen, JL; Chi, JT; Dewhirst, M; Lucas, JE; Mori, S; Nevins, J; Schroeder, T; West, M; Wu, J, 2008) |
" A randomized controlled study was designed to examine the dose-response effect of dobutamine (5-20 microg x kg(-1) x min(-1)) on systemic and regional circulations and oxygen metabolism in a neonatal swine model of hypoxia/reoxygenation." | 7.74 | The hemodynamic effects of dobutamine during reoxygenation after hypoxia: a dose-response study in newborn pigs. ( Abozaid, S; Al-Salam, Z; Bigam, D; Cheung, PY; Johnson, S, 2007) |
"We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model." | 7.73 | Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005) |
" To gain a better understanding of the mechanisms responsible for oxygen and nutrient sensing in chondrocytes, we investigated the effects of hypoxic stimulation induced by cobalt chloride treatment (a hypoxia-mimetic) on glucose uptake and lactate production in chondrocytes." | 7.73 | Regulation of 2-deoxy-D-glucose transport, lactate metabolism, and MMP-2 secretion by the hypoxia mimetic cobalt chloride in articular chondrocytes. ( Mobasheri, A; Platt, N; Shakibaei, M; Thorpe, C, 2006) |
" We hypothesized that ephedrine and phenylephrine, administered for maternal hypotension following fetal hypoxaemia, are equal in respect of fetal outcome." | 7.72 | Effects of ephedrine and phenylephrine on uterine and placental circulations and fetal outcome following fetal hypoxaemia and epidural-induced hypotension in a sheep model. ( Alahuhta, S; Erkinaro, T; Kavasmaa, T; Mäkikallio, K; Räsänen, J, 2004) |
" To study the effect of acute moderate hypoxia on plasma lactic acid (LA) and lactic dehydrogenase (LDH) content in pilots." | 7.70 | [Effects of acute hypoxia on plasma lactic acid and lactic dehydrogenase content in pilots]. ( Li, WB; Liu, Y; Qin, SZ, 2000) |
"The influence of systemic hypoxia on lactate and adenosine output from isolated constant-flow-perfused gracilis muscle was determined in anesthetized dogs." | 7.69 | Intracellular lactate controls adenosine output from dog gracilis muscle during moderate systemic hypoxia. ( Ballard, HJ; Mo, FM, 1997) |
"The role of inhibition of the CPT enzymes responsible for accumulation of long chain acylcarnitines (LCAC) during hypoxia in the proximal tubule has not been previously examined." | 7.69 | Carnitine palmitoyl-transferase enzyme inhibition protects proximal tubules during hypoxia. ( Portilla, D, 1997) |
"We tested whether digoxin would limit tissue hypoxia during severe anemia by improving peripheral O2 distribution or decreasing O2 demands." | 7.68 | Oxygen transport during anemic hypoxia in pigs: effects of digoxin on metabolism. ( Hendler, R; Lister, G; Saltiel, A; Sanfilippo, DJ, 1992) |
"The relationships between the concentrations of glycogen, glucose, lactate, adenosine triphosphate (ATP) and hypoxanthine in the brain tissue, and the hypoxanthine and lactate concentration in cerebrospinal fluid and blood were examined after exposure of rats to hypoxia." | 7.67 | Concentration of hypoxanthine in both cerebrospinal fluid and brain tissue increases under intensive hypoxia only. ( Gross, J; Lun, A; Pohle, R; Siggel, H, 1988) |
"The role of lactic acidosis of progressive brain hypoxia (PBH) as both a central chemoreceptor stimulant and a general respiratory depressant was assessed by preventing lactate formation both locally and globally with dichloroacetate (DCA)." | 7.67 | Role of brain lactic acidosis in hypoxic depression of respiration. ( Edelman, NH; Neubauer, JA; Simone, A, 1988) |
"To determine the suitability of plasma hypoxanthine as a marker of tissue hypoxia, we studied the relationship of arterial plasma hypoxanthine and blood lactate concentrations to the cumulative O2 deficit during hypoxemia and low cardiac output (hypoxic and stagnant hypoxia, respectively)." | 7.67 | Hypoxanthine and lactate concentrations in lambs during hypoxic and stagnant hypoxia. ( Kurzner, S; Lister, G; Moss, M; Razlog, Y, 1988) |
"Hypoxic lactic acidosis (HLA) was induced in dogs by ventilating them with a hypoxic gas mixture of 8% O2-92% N2." | 7.67 | Pathophysiology of type A hypoxic lactic acidosis in dogs. ( Arieff, AI; Graf, H, 1987) |
"To test the hypothesis that adenosine is required to mediate the coronary vasodilative response to acute hypoxia haemodynamic indices, regional myocardial blood flow, and oxygen and lactate metabolism were measured in nine closed chest anaesthetised domestic swine at control, after 3-5 min of 100% nitrogen inhalation, at second control, and after 3-5 min of 100% nitrogen inhalation plus adenosine deaminase infusion in the left anterior descending coronary artery." | 7.67 | Role of adenosine in mediating the coronary vasodilative response to acute hypoxia. ( Gewirtz, H; Most, AS; Olsson, RA, 1987) |
"Experimental factors implicated in the pathogenesis of halothane hepatotoxicity in the phenobarbital-hypoxia rat model were examined for direct effects on the energy status of isolated rat liver cells in vitro." | 7.67 | Energy deficits in hepatocytes isolated from phenobarbital-treated or fasted rats and briefly exposed to halothane and hypoxia in vitro. ( Albrecht, RF; Becker, GL; Hensel, P; Holland, AD; Miletich, DJ, 1986) |
"The effect of hypoxia on the elimination of omeprazole, a potent inhibitor of gastric acid secretion, was studied in the isolated perfused rat liver." | 7.67 | Effect of hypoxia on oxidative and reductive pathways of omeprazole metabolism by the isolated perfused rat liver. ( Jones, DB; Mihaly, GW; Morgan, DJ; Smallwood, RA; Webster, LK, 1985) |
"In mice, changes of body temperature and concentration of lactic acid in the blood were studied after three modes of barochamber hypoxia (altitude 8000 m) at the temperatures +10, +20 and +36 degrees C." | 7.67 | [Effect of short-term hypoxia on body temperature and lactic acid in the blood of the mouse]. ( Pisarenko, SN; Sepisheva, AS; Slonim, AD, 1985) |
"The possibility of detecting past hypoxia during the first 2 h after birth by means of blood analyses of hypoxanthine, lactate, base deficit, and pH was investigated in six infants with a 1 min Apgar score of less than or equal to 4." | 7.66 | Hypoxanthine as a test of perinatal hypoxia as compared to lactate, base deficit, and pH. ( Bratteby, LE; Swanström, S, 1982) |
"During prolonged anoxia at low temperature, freshwater turtles develop high plasma concentrations of both lactate and calcium." | 6.42 | Surviving extreme lactic acidosis: the role of calcium lactate formation in the anoxic turtle. ( Jackson, DC, 2004) |
"This study demonstrates that acute high altitude hypoxia upregulated the lactic acid/amino acid-pyruvate-TCA pathways and fatty acid oxidation, but downregulated glycolysis in the liver of mice." | 5.91 | Energy metabolic mechanisms for high altitude sickness: Downregulation of glycolysis and upregulation of the lactic acid/amino acid-pyruvate-TCA pathways and fatty acid oxidation. ( Jiang, C; Li, Y; Liao, N; Liu, G; Shang, X; Shao, D; Shi, J; Xu, F; Yin, D, 2023) |
"Ischemia was followed by a significant increase in muscle myeloperoxidase activity, as well as interleukin-6 and thiobarbituric acid reactive substances species levels." | 5.48 | N-acetylcysteine effects on a murine model of chronic critical limb ischemia. ( Constantino, L; da Silva, LA; Dal-Pizzol, F; Dall'Igna, DM; de Medeiros, WA; Dos Santos Cardoso, J; Manfredini, A; Michels, M; Ritter, C; Scaini, G; Streck, EL; Vuolo, F, 2018) |
"High uric acid (UA) has been found to be correlated with renal dysfunction in some experimental and clinical studies; however, the study of the dynamic correlation between AKI and UA in severe burns is still lacking." | 5.42 | Elevated serum uric acid after injury correlates with the early acute kidney in severe burns. ( Hu, X; Liang, J; Zhang, P; Zhi, L, 2015) |
"Adenosine is a product of adenylate phosphate breakdown that can exert protective effects on tissues during energy limitation." | 5.32 | Cardiorespiratory and tissue adenosine responses to hypoxia and reoxygenation in the short-horned sculpin Myoxocephalus scorpius. ( Driedzic, WR; Maccormack, TJ, 2004) |
"During sow parturition, there is need for an alternative uterotonic to oxytocin with less potency so piglets are not at risk of hypoxia and stillbirth." | 5.30 | Effects of oxytocin and carbetocin on farrowing performance. ( Kirkwood, RN; Plush, KL; Ward, SA, 2019) |
"To evaluate the effect of hypoxemia on cardiac release of neuropeptide Y-like immunoreactivity (NPY-LI) and norepinephrine (NE), arterial and coronary sinus blood was sampled and coronary sinus blood flow was measured by thermodilution in nine healthy volunteers at rest and during supine cycle ergometer exercise while they breathed air and 12% O2, which reduced arterial O2 saturation to approximately 68%." | 5.29 | Neuropeptide Y release from human heart is enhanced during prolonged exercise in hypoxia. ( Berglund, B; Grubbström, J; Kaijser, L; Lundberg, JM; Pernow, J, 1994) |
"During CO2 acidosis, anoxia had no effect on apparent nonbicarbonate buffer value (d[HCO3-]/dpHi = 71 and 89 mM/pH in normoxia and anoxia, respectively) or on pHi regulation (dpHi/dpHe = 0." | 5.28 | 31P-NMR study of normoxic and anoxic perfused turtle heart during graded CO2 and lactic acidosis. ( Arendt, EA; Inman, KC; Jackson, DC; Lawler, RG; Panol, G; Wasser, JS, 1991) |
"The purpose of the present investigation was to determine the independent effects of hypoxia and physical exercise on peripheral cholecystokinin (CCK) metabolism in humans." | 5.09 | Physical exercise and normobaric hypoxia: independent modulators of peripheral cholecystokinin metabolism in man. ( Bailey, DM; Calam, J; Castell, LM; Davies, B; Newsholme, EA, 2001) |
"In this study the authors examine the effects of acute hypoxia due to extracorporeal circulation (ECC) and the role played by L-carnitine treatment on some plasmatic metabolites linked to glycolytic cellular metabolism." | 5.07 | Metabolic aspects of acute tissue hypoxia during extracorporeal circulation and their modification induced by L-carnitine treatment. ( Cogliatti, A; Corbucci, GG; Menichetti, A; Nicoli, P; Ruvolo, C, 1992) |
"L-lactic acidosis (L-LA) is the most common cause of metabolic acidosis in the critical care setting, which has been associated with a large increase in mortality." | 5.05 | L-lactic acidosis: pathophysiology, classification, and causes; emphasis on biochemical and metabolic basis. ( Halperin, ML; Kamel, KS; Oh, MS, 2020) |
" anaerobic glycolysis sustaining ATP production in supramaximal exercise as well as in conditions of hypoxia and ischemia, is responsible for the accumulation of large amounts of lactic acid (up to 1 mol for the whole body)." | 4.82 | Acid-base balance at exercise in normoxia and in chronic hypoxia. Revisiting the "lactate paradox". ( Cerretelli, P; Samaja, M, 2003) |
" These factors (immaturity, hyperoxia, hypoxia, blood transfusions, intraventricular hemorrhage, apnea, infection, hypercarbia, hypocarbia, patent ductus arteriosus, prostaglandin synthetase inhibitors, vitamin E deficiency, lactic acidosis, prenatal complications, genetic factors) may all be present in an infant." | 4.76 | A reexamination of the role of oxygen in retrolental fibroplasia. ( Dangman, B; Lucey, JF, 1984) |
" MCT4 is associated with the export of lactic acid from cancer cells under hypoxia, so inhibition of MCT4 may lead to cytotoxic levels of intracellular lactate." | 4.31 | Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology. ( Beattie, D; Buttar, D; Clark, R; Cook, CR; Critchlow, SE; Goldberg, FW; Hopcroft, L; Hughes, G; Kavanagh, SL; Kawatkar, A; Kettle, JG; Komen, JC; Lamont, GM; McGuire, TM; Morentin Gutierrez, P; Ting, AKT, 2023) |
" As S-adenosylhomocysteine (SAH) was shown to reflect tissue hypoxia, we compared the ability of SAH versus lactate to predict the progression of inflammatory and septic disease to septic organ dysfunction and death." | 4.31 | S-Adenosylhomocysteine Is a Useful Metabolic Factor in the Early Prediction of Septic Disease Progression and Death in Critically Ill Patients: A Prospective Cohort Study. ( Brohm, K; Centner, FS; Fuderer, T; Hahn, B; Jäger, E; Krebs, J; Lindner, HA; Mindt, S; Neumaier, M; Schneider-Lindner, V; Schoettler, JJ; Thiel, M, 2023) |
" Acute poisoning occurred after taking 100 ml of 1,4-butanediol together with phenyl-2- (1-pyrrolidinyl) -1-pentanone and 2 g of methadone, clinically manifested in the form of convulsive syndrome, depression of consciousness to the level of coma 3, edema and swelling brain, acute respiratory failure, mixed decompensated respiratory and metabolic lactic acidosis (pH 7." | 4.12 | [CLINICAL CASE OF ACUTE SEVERE COMBINED POISONING WITH NARCOTIC SUBSTANCES OF DEPENDENT AND PSYCHOSTIMULATING EFFECTS]. ( Antonova, A; Batotsyrenov, B; Kovalenko, A; Lodyagin, A; Loladze, A; Sinenchenko, A, 2022) |
"This study suggests that caffeic acid inhibits PHD2 enzyme activity which then activates the hypoxia-associated transcription factor HIF leading to a neuroprotective effect against hypoxia." | 4.12 | The novel prolyl hydroxylase-2 inhibitor caffeic acid upregulates hypoxia inducible factor and protects against hypoxia. ( Diao, A; Guo, B; Guo, Z; Hao, L; Li, L; Li, Y; Liu, Z; Yang, Y; Zhao, Q, 2022) |
"Hypoxia and high accumulation of lactic acid in the tumor microenvironment provide fertile soil for tumor development, maintenance and metastasis." | 4.12 | Acidic and hypoxic tumor microenvironment regulation by CaO ( Chang, J; Dong, H; Li, Y; Liu, Y; Ma, X; Ren, T; Ruan, S; Sun, J; Yang, Y; Yin, W; Zang, J, 2022) |
" Initial severe acidosis consisted of acute respiratory acidosis from ventilation-perfusion mismatch and acute metabolic acidosis resulting from bronchospasm and hypoxia-related lactic acidosis, respectively." | 4.02 | Salbutamol-induced lactic acidosis in status asthmaticus survivor. ( Boonkaya, S; Phoophiboon, V; Singhagowinta, P; Sriprasart, T, 2021) |
"The pathological expression and function of lactate dehydrogenase A (LDHA), a key enzyme that converts pyruvate into lactic acid during glycolysis, remains unknown in endometriosis." | 4.02 | Hypoxia‑induced lactate dehydrogenase A protects cells from apoptosis in endometriosis. ( Dai, Y; Huang, Q; Jin, X; Lin, X; Liu, N; Shi, L; Zhang, S; Zheng, J; Zhou, F, 2021) |
"In this study, C57BL/6 J mice were administrated with an Nrf2 activator, sulforaphane (SFN) before taking incremental treadmill exercise to exhaustion under hypoxia; then the effects of SFN on exercise endurance and molecular/biochemical makers of the skeletal muscle were evaluated." | 3.96 | Nrf2 Activation Enhances Muscular MCT1 Expression and Hypoxic Exercise Capacity. ( Wang, J; Wang, L; Yu, S; Zhang, Y; Zhu, R, 2020) |
" The effects of different doses of FOPS on the loaded-swimming time, the content of serum urea nitrogen, the blood lactic acid, the hepatic glycogen and the muscle glycogen after exercise, the survival time under hypoxia at normal pressure and the maintenance time after decapitation were observed." | 3.91 | [Effects of the Fomes officinalis Ames. polysaccharides on anti-fatigue and hypoxia tolerance in mice]. ( Hao, HY; Sha, AL, 2019) |
"The effect of lactic acidosis on neurological development in the first year of life." | 3.88 | Neurological impairments in hypoxic neonates and lactate levels. ( Jovandaric, MZ; Milenkovic, SJ, 2018) |
"We evaluated the influence of hypoxic hypoxia on lactate, creatinine and urea concentrations in the amniotic fluid (AF) of rabbits on 27-28th day of pregnancy." | 3.85 | [Acute hypoxic hypoxia increases lactate concentration in amniotic fluid of rabbits on 27-28th day of pregnancy]. ( Korenovsky, YV; Popovtseva, AV; Suzopov, EV, 2017) |
" Biotin-deficient rats show a syndrome characterized by marked weight loss, metabolic lactic acidosis, aciduria and accelerated breathing with normal responsiveness to hypoxia." | 3.83 | Selective accumulation of biotin in arterial chemoreceptors: requirement for carotid body exocytotic dopamine secretion. ( Arias-Mayenco, I; Bonilla-Henao, V; González-Rodríguez, P; Levitsky, KL; López-Barneo, J; Macías, D; Ortega-Sáenz, P; Rodríguez-Gómez, JA, 2016) |
"This study evaluated the effects of thiamine pyrophosphate (PPT) on the biochemical profiles of full-term rabbit foetuses that were subjected to experimental ischemia followed by 24h reperfusion." | 3.83 | Evaluation of the protective effect of thiamine pyrophosphate based on the biochemical analysis of rabbit foetuses at 30 days of gestation. ( Alonso-Spilsbury, M; Arch-Tirado, E; Jiménez-Bravo, MA; Martínez-Burnes, J; Mora-Medina, P; Mota-Rojas, D; Orozco-Gregorio, H; Pérez-Guille, B; Roldan-Santiago, P; Soriano-Rosales, R, 2016) |
"In this study, blood redox potential (ORP) values (ΔORP value was adopted, as the quantitative index to reflect the overall redox status), plasma uric acid levels (important antioxidant, as antioxidant index), and the burn shock state-related indicators (lactic acid and hematocrit) of 48 burn patients were dynamically, quantitatively monitored during the early stage after injury." | 3.81 | The characteristics and correlation between the ischemia-reperfusion and changes of redox status in the early stage of severe burns. ( Han, C; Hu, H; Hu, X; Pan, X; Shao, H; Xu, J; Yu, C; Zhi, L, 2015) |
" These measurements indicate that apoptosis was the primary mechanism of cell death; acidity was not caused by lactic acid; and cell death was caused by depletion of carbon sources and not hypoxia." | 3.80 | Rapid uptake of glucose and lactate, and not hypoxia, induces apoptosis in three-dimensional tumor tissue culture. ( Forbes, NS; Kasinskas, RW; Venkatasubramanian, R, 2014) |
"The present study is an attempt to leverage therapeutic benefits of curcumin in pulmonary hypertension by encapsulating it in biodegradable poly(lactide-co-glycolic) acid nanoparticles." | 3.78 | Tissue localization of nanoparticles is altered due to hypoxia resulting in poor efficacy of curcumin nanoparticles in pulmonary hypertension. ( Devadasu, VR; Ravi Kumar, MN; Wadsworth, RM, 2012) |
" In the present study, both afferent nerves and either of them were activated by muscle contraction, passive tendon stretch, and arterial injection of lactic acid into the hindlimb muscles." | 3.78 | Role for NGF in augmented sympathetic nerve response to activation of mechanically and metabolically sensitive muscle afferents in rats with femoral artery occlusion. ( Li, J; Lu, J; Xing, J, 2012) |
"The effectiveness of sodium bicarbonate (SB) has recently been questioned although it is often used to correct metabolic acidosis of neonates." | 3.78 | Infusing sodium bicarbonate suppresses hydrogen peroxide accumulation and superoxide dismutase activity in hypoxic-reoxygenated newborn piglets. ( Bigam, DL; Cheung, PY; Lee, TF; Liu, JQ; Manouchehri, N; Yao, M, 2012) |
"Intraluminal microdialysis revealed signs of intestinal hypoxia and cellular damage, with a marked increase of lactate and glycerol." | 3.78 | Intraluminal intestinal microdialysis detects markers of hypoxia and cell damage in experimental necrotizing enterocolitis. ( Carlsson, PO; Hillered, L; Högberg, N; Lilja, HE; Stenbäck, A, 2012) |
"Nude mice bearing FaDu, UT-SCC-15, and UT-SCC-5 hSCC were injected with pimonidazole hypoxia and Hoechst perfusion markers." | 3.75 | Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts. ( Baumann, M; Meyer, S; Mueller-Klieser, W; Quennet, V; Shakirin, G; Walenta, S; Yaromina, A; Zips, D, 2009) |
", samples with HMGB-1 levels >2 SD above the mean level in samples from patients with noninflammatory arthropathy), concentrations of HMGB-1 were significantly correlated with those of lactic acid, a marker of tissue hypoxia." | 3.74 | Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis. ( Abeyama, K; Fukuda, T; Fukuzaki, K; Hamada, T; Hashiguchi, K; Horai, N; Komiya, S; Kuwazuru, A; Maruyama, I; Nagata, R; Nagayama, S; Sunahara, N; Tanaka, M; Torikai, M; Yamada, S, 2008) |
"Phosphocreatine (PCr) was reduced to equivalent levels in carp white muscle by high-intensity exhaustive exercise and exposure to hypoxia at 15 degrees C and 25 degrees C in order to assess the influence of intracellular pH (pH(i)), temperature and lactate levels on PCr recovery in vivo." | 3.74 | Differential recovery from exercise and hypoxia exposure measured using 31P- and 1H-NMR in white muscle of the common carp Cyprinus carpio. ( Hallman, TM; Jones, DR; Richards, JG; Rojas-Vargas, AC, 2008) |
" Two important determinants in this environment are hypoxia and lactic acidosis." | 3.74 | The genomic analysis of lactic acidosis and acidosis response in human cancers. ( Chen, JL; Chi, JT; Dewhirst, M; Lucas, JE; Mori, S; Nevins, J; Schroeder, T; West, M; Wu, J, 2008) |
" Tissue glucose uptake and cardiovascular characteristics were measured in the short-horned sculpin, Myoxocephalus scorpius, a species exhibiting low blood glucose levels, during normoxia and hypoxia to assess the role of adenosine receptors in the control of glucose uptake and anaerobic metabolism." | 3.74 | The impact of hypoxia on in vivo glucose uptake in a hypoglycemic fish, Myoxocephalus scorpius. ( Driedzic, WR; MacCormack, TJ, 2007) |
" Our results demonstrate that 1) males sustain isometric force production (F) longer than females under hyperoxia (P O2 = 640 mmHg) with exogenous glucose present; 2) contractility is not maintained under moderate (P O2 = 130 mmHg) or severe hypoxia (P O2 = 10-20 mmHg) with glucose in either sex; however, following reoxygenation, F is higher in females compared with males; and 3) female tissue has higher lactate levels, net lactate efflux, and lactate dehydrogenase activity than males, whereas males have higher glycogen, citrate synthase, and beta-hydroxy acyl-CoA dehydrogenase activities, and greater inotropic responses to exogenous glucose and octanoate." | 3.74 | Sex differences in energy metabolism and performance of teleost cardiac tissue. ( Battiprolu, PK; Harmon, KJ; Rodnick, KJ, 2007) |
" Taurine may have been released by the tissues as a protective mechanism against hypoxia-induced inflammation, or in an attempt to maintain osmotic balance." | 3.74 | Taurine as a marker for foetal wellbeing? ( de Boo, HA; Harding, JE, 2007) |
" A randomized controlled study was designed to examine the dose-response effect of dobutamine (5-20 microg x kg(-1) x min(-1)) on systemic and regional circulations and oxygen metabolism in a neonatal swine model of hypoxia/reoxygenation." | 3.74 | The hemodynamic effects of dobutamine during reoxygenation after hypoxia: a dose-response study in newborn pigs. ( Abozaid, S; Al-Salam, Z; Bigam, D; Cheung, PY; Johnson, S, 2007) |
" Extracellular pH defense against lactic acidosis was estimated from changes (Delta) in lactic acid ([La]), [HCO3-], pH and PCO2 in plasma, which equilibrates with interstitial fluid." | 3.74 | Extracellular pH defense against lactic acid in untrained and trained altitude residents. ( Böning, D; Coy, L; Mora, M; Reyes, O; Rojas, J; Serrato, M, 2008) |
"We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model." | 3.73 | Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005) |
"Acute hypoxia increases cerebral lactate and alanine in NG chick embryos; these increases are reduced by pre-exposure to substrate deprivation and chronic hypoxia." | 3.73 | Growth restriction and the cerebral metabolic response to acute hypoxia of chick embryos in-ovo: a proton magnetic resonance spectroscopy study. ( Cady, EB; Dixon, JC; Peebles, DM; Priest, AN; Thornton, JS, 2005) |
" This effect disappeared, however, when hypoxia was combined with acidosis obtained by 24 mM lactic acid." | 3.73 | Force development at elevated [Mg2+]o and [K+]o in myocardium from the freshwater turtle (Trachemys scripta) and influence of factors associated with hibernation. ( Gesser, H, 2006) |
" To gain a better understanding of the mechanisms responsible for oxygen and nutrient sensing in chondrocytes, we investigated the effects of hypoxic stimulation induced by cobalt chloride treatment (a hypoxia-mimetic) on glucose uptake and lactate production in chondrocytes." | 3.73 | Regulation of 2-deoxy-D-glucose transport, lactate metabolism, and MMP-2 secretion by the hypoxia mimetic cobalt chloride in articular chondrocytes. ( Mobasheri, A; Platt, N; Shakibaei, M; Thorpe, C, 2006) |
" Incubation at hypoxia resulted in increased lactate concentrations, whereas ATP, glucose, and glycogen concentrations were decreased, especially in the mid media, where concentrations of these metabolites were close to zero." | 3.72 | Mapping of ATP, glucose, glycogen, and lactate concentrations within the arterial wall. ( Björnheden, T; Bondjers, G; Evaldsson, M; Leppänen, O; Levin, M; Wiklund, O, 2003) |
" We conclude that caiman osteoderms sequester lactate during lactic acidosis and that the time course is fast enough to have benefit to these animals following normal anaerobic burst activity." | 3.72 | Lactate sequestration by osteoderms of the broad-nose caiman, Caiman latirostris, following capture and forced submergence. ( Abe, AS; Andrade, DV; Jackson, DC, 2003) |
" The addition of the glucose transporter inhibitor cytochalasin B caused hypoxic hearts to fail early, and hearts perfused with a glucose analogue, 2-deoxyglucose (2-DG), increased glucose uptake 3-fold under hypoxia." | 3.72 | The regulation and importance of glucose uptake in the isolated Atlantic cod heart: rate-limiting steps and effects of hypoxia. ( Clow, KA; Driedzic, WR; MacCormack, TJ; Rodnick, KJ, 2004) |
" We hypothesized that ephedrine and phenylephrine, administered for maternal hypotension following fetal hypoxaemia, are equal in respect of fetal outcome." | 3.72 | Effects of ephedrine and phenylephrine on uterine and placental circulations and fetal outcome following fetal hypoxaemia and epidural-induced hypotension in a sheep model. ( Alahuhta, S; Erkinaro, T; Kavasmaa, T; Mäkikallio, K; Räsänen, J, 2004) |
" Hypoxia induced an immediate and significant elevation in the intraperitoneal lactate/pyruvate ratio to 446+/-137% of the baseline values, and glycerol subsequently increased during reoxygenation to 389+/-109%." | 3.71 | Intraperitoneal microdialysis for detection of splanchnic metabolic disorders. ( Bahlmann, L; Bruch, HP; Gliemroth, J; Heringlake, M; Klaus, S, 2002) |
" Under conditions of acute hypoxia induced by breathing carbon monoxide at 660 ppm, the apparent glycolytic rate was 0." | 3.71 | Effect of changing tumor oxygenation on glycolytic metabolism in a murine C3H mammary carcinoma assessed by in vivo nuclear magnetic resonance spectroscopy. ( Bentzen, L; Daugaard, P; Horsman, MR; Maxwell, RJ; Nielsen, FU; Overgaard, J; Stødkilde-Jørgensen, H, 2001) |
" Hyperlactatemia with L/P ratio elevation and lactic acidosis is likely to be associated with inadequate tissue perfusion." | 3.70 | Time-pattern of lactate and lactate to pyruvate ratio in the first 24 hours of intensive care emergency admissions. ( Kari, A; Ruokonen, E; Suistomaa, M; Takala, J, 2000) |
"We investigated the metabolic effects of buffering agents alpha-amino-4-imidazole-propionic acid (Histidine), N, N-bis(2-hydroxyethyl)glycine (bicine), N, N-bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES) on anaerobic energy production (via glycolysis) and conservation of key regulatory enzyme activity, and phosphofructokinase (PFK) throughout prolonged hypothermic hypoxia in porcine hearts." | 3.70 | Conservation of phosphorylation state of cardiac phosphofructokinase during in vitro hypothermic hypoxia. ( Churchill, TA; Kneteman, NM; Pulis, RP; Wu, BM, 2000) |
" To study the effect of acute moderate hypoxia on plasma lactic acid (LA) and lactic dehydrogenase (LDH) content in pilots." | 3.70 | [Effects of acute hypoxia on plasma lactic acid and lactic dehydrogenase content in pilots]. ( Li, WB; Liu, Y; Qin, SZ, 2000) |
"This study examines the neonatal response to graded hypoxia and determines the arterial PO2 (PaO2) threshold for oxygen-restricted metabolism as confirmed by the development of lactic acidosis and altered oxygen handling." | 3.69 | Blood lactate and acid-base balance in graded neonatal hypoxia: evidence for oxygen-restricted metabolism. ( Torrance, SM; Wittnich, C, 1994) |
"Isovolumetric rat hearts (37 degrees C) were treated with 1 microM (apri 1) or 30 microM (apri 30) aprikalim, or preconditioned with either 10 min of hypoxia (N2PC) or 5 min of ischaemia followed by 5 min of perfusion (IPC5) or 10 min of ischaemia followed by 3 min of perfusion (IPC10)." | 3.69 | Comparison of effects of aprikalim and of hypoxic and ischaemic preconditioning on extracellular potassium accumulation, metabolism, and functional recovery of the globally ischaemic rat heart. ( Diacono, J; Feuvray, D; Guo, AC, 1994) |
"The present study was designed to determine whether lactate changes the critical pH point at which the recovery of rat population spike is inhibited following glucose-oxygen deprivation and second, which degree of lactic acidosis is similar to the effect of CO2 acidosis." | 3.69 | Effect of lactic and CO2 acidosis on neuronal function following glucose-oxygen deprivation in rat hippocampal slices. ( Kemmotsu, O; Morimoto, Y, 1994) |
"The goal of this study was to evaluate whether sodium bicarbonate might be a useful form of therapy for hypoxic L-lactic acidosis; our aim was to determine if alkali could extend the time of survival in this setting." | 3.69 | Alkali therapy extends the period of survival during hypoxia: studies in rats. ( Cheema-Dhadli, S; Chen, CB; Halperin, FA; Halperin, ML, 1996) |
"The influence of systemic hypoxia on lactate and adenosine output from isolated constant-flow-perfused gracilis muscle was determined in anesthetized dogs." | 3.69 | Intracellular lactate controls adenosine output from dog gracilis muscle during moderate systemic hypoxia. ( Ballard, HJ; Mo, FM, 1997) |
"In isovolumically perfused Langendorff heart preparations of guinea pigs adenosine-depending on the experimental protocol-more or less could prevent the hypoxia-induced decrease in myocardial adenosine triphosphate [ATP], creatine phosphate [CP], glycogen and increase in lactate, i." | 3.69 | On the cardioprotective effect of adenosine. ( Kovács, P; Nosztray, K; Szabó, JZ; Szegi, J; Szentmiklósi, AJ; Ujfalusi, A; Varga, E, 1996) |
"The role of inhibition of the CPT enzymes responsible for accumulation of long chain acylcarnitines (LCAC) during hypoxia in the proximal tubule has not been previously examined." | 3.69 | Carnitine palmitoyl-transferase enzyme inhibition protects proximal tubules during hypoxia. ( Portilla, D, 1997) |
"Experiments are described in which a rat hippocampal slice preparation was used along with the metabolic glial inhibitor, fluorocitrate (FC), to investigate the role of glial-made lactate and its shuttling to neurons in posthypoxia recovery of synaptic function." | 3.69 | Glia are the main source of lactate utilized by neurons for recovery of function posthypoxia. ( Miller, JJ; Payne, RS; Rigor, BM; Schurr, A, 1997) |
" The application of cyanide (to mimic hypoxia) produced a fall of the concentration of phosphocreatine ([PCr]) and a rise of those of inorganic phosphate ([Pi]) and sugar phosphates." | 3.68 | Relationship between intracellular pH and metabolite concentrations during metabolic inhibition in isolated ferret heart. ( Bauer, CJ; Donoso, P; Eisner, DA; Smith, GL, 1993) |
"Flux through the adenosine production and degradation pathways is transiently increased during hypoxia." | 3.68 | Interstitial purine metabolites and lactate during regional myocardial hypoxia. ( Downey, HF; Van Wylen, DG; Williams, AG, 1993) |
"We tested the hypotheses that in newborn piglets indomethacin (Indo) pretreatment blunts the hyperemic brain blood flow (BF) and alters the cerebral metabolic responses to hypoxia and that these responses are dose dependent." | 3.68 | Effects of indomethacin on brain blood flow and cerebral metabolism in hypoxic newborn piglets. ( Coyle, MG; Oh, W; Stonestreet, BS, 1993) |
"Previous studies in this laboratory showed that hypoxia and anoxia enhance the susceptibility of hepatocytes to tert-butylhydroperoxide (TBH)-induced oxidative injury." | 3.68 | Postanoxic oxidative injury in rat hepatocytes: lactate-dependent protection against tert-butylhydroperoxide. ( Aw, TY; Jones, DP; Kowalski, DP; Park, Y, 1992) |
"Lactic acid, the end metabolic product of anaerobic glycolysis is probably the mediator of the hypoxia induced vasodilation on retinal arterioles." | 3.68 | [Metabolic factors of vasomotor regulation of the inner retina]. ( Brazitikos, PD; Munoz, JL; Pournaras, CJ; Tsacopoulos, M, 1992) |
"We tested whether digoxin would limit tissue hypoxia during severe anemia by improving peripheral O2 distribution or decreasing O2 demands." | 3.68 | Oxygen transport during anemic hypoxia in pigs: effects of digoxin on metabolism. ( Hendler, R; Lister, G; Saltiel, A; Sanfilippo, DJ, 1992) |
" We hypothesized that the lactic acidosis associated with prolonged systemic hypoxemia might mediate the adaptation of the hypoxemic inhibition of FBM." | 3.68 | Vascular lactic acid infusions do not alter the incidence of fetal breathing movements or their inhibition by acute hypoxemia. ( Bissonnette, JM; Hohimer, AR, 1991) |
"In the rat vas deferens (preloaded with 3H-noradrenaline, catechol-O-methyl transferase inhibited, calcium-free solution) ouabain, glucose deprivation or the combination of hypoxia plus presence of lactate were found to induce a carrier-mediated (desipramine-sensitive) outward transport of the 3H-amine." | 3.68 | The energy requirements for the basal efflux of 3H-noradrenaline from sympathetically innervated organs. ( Russ, H; Schömig, E; Trendelenburg, U, 1991) |
" To study this problem, acute isocapnic metabolic acidosis was induced by HCl or lactic acid infusions in rats, and recovery from acidosis was accomplished by NaHCO3 infusion." | 3.68 | Brain pH in acute isocapnic metabolic acidosis and hypoxia: a 31P-nuclear magnetic resonance study. ( Adler, S; Ho, C; Simplaceanu, V, 1990) |
"88 mM Amytal (amobarbital), hypoxia (95% N2-5% CO2), or 12 microM adenosine in the presence and absence of 2." | 3.67 | Relationship of myocardial metabolism and coronary flow: dependence on extracellular calcium. ( Erecińska, M; Rumsey, WL; Wilson, DF, 1987) |
" We studied the effects of carbicarb in an animal preparation of hypoxic lactic acidosis (HLA)." | 3.67 | Improved hemodynamic function during hypoxia with Carbicarb, a new agent for the management of acidosis. ( Arieff, AI; Bersin, RM, 1988) |
"The relationships between the concentrations of glycogen, glucose, lactate, adenosine triphosphate (ATP) and hypoxanthine in the brain tissue, and the hypoxanthine and lactate concentration in cerebrospinal fluid and blood were examined after exposure of rats to hypoxia." | 3.67 | Concentration of hypoxanthine in both cerebrospinal fluid and brain tissue increases under intensive hypoxia only. ( Gross, J; Lun, A; Pohle, R; Siggel, H, 1988) |
"The role of lactic acidosis of progressive brain hypoxia (PBH) as both a central chemoreceptor stimulant and a general respiratory depressant was assessed by preventing lactate formation both locally and globally with dichloroacetate (DCA)." | 3.67 | Role of brain lactic acidosis in hypoxic depression of respiration. ( Edelman, NH; Neubauer, JA; Simone, A, 1988) |
"To determine the suitability of plasma hypoxanthine as a marker of tissue hypoxia, we studied the relationship of arterial plasma hypoxanthine and blood lactate concentrations to the cumulative O2 deficit during hypoxemia and low cardiac output (hypoxic and stagnant hypoxia, respectively)." | 3.67 | Hypoxanthine and lactate concentrations in lambs during hypoxic and stagnant hypoxia. ( Kurzner, S; Lister, G; Moss, M; Razlog, Y, 1988) |
"Hypoxic lactic acidosis (HLA) was induced in dogs by ventilating them with a hypoxic gas mixture of 8% O2-92% N2." | 3.67 | Pathophysiology of type A hypoxic lactic acidosis in dogs. ( Arieff, AI; Graf, H, 1987) |
"To test the hypothesis that adenosine is required to mediate the coronary vasodilative response to acute hypoxia haemodynamic indices, regional myocardial blood flow, and oxygen and lactate metabolism were measured in nine closed chest anaesthetised domestic swine at control, after 3-5 min of 100% nitrogen inhalation, at second control, and after 3-5 min of 100% nitrogen inhalation plus adenosine deaminase infusion in the left anterior descending coronary artery." | 3.67 | Role of adenosine in mediating the coronary vasodilative response to acute hypoxia. ( Gewirtz, H; Most, AS; Olsson, RA, 1987) |
" Reduced ATP and phosphocreatine content, intracellular acidosis related to hypercapnia, increased muscle lactate without alterations of the muscle lactate concentration gradient were observed in the skeletal muscle of the hypercapnic-hypoxemic COPD patients studied, in which group no correlation was found between hypoxia and energy or lactate metabolism parameters." | 3.67 | Skeletal muscle energetics, acid-base equilibrium and lactate metabolism in patients with severe hypercapnia and hypoxemia. ( Coffrini, E; Del Canale, S; Fiaccadori, E; Guariglia, A; Ronda, N; Vitali, P, 1987) |
"Experimental factors implicated in the pathogenesis of halothane hepatotoxicity in the phenobarbital-hypoxia rat model were examined for direct effects on the energy status of isolated rat liver cells in vitro." | 3.67 | Energy deficits in hepatocytes isolated from phenobarbital-treated or fasted rats and briefly exposed to halothane and hypoxia in vitro. ( Albrecht, RF; Becker, GL; Hensel, P; Holland, AD; Miletich, DJ, 1986) |
"The effect of hypoxia on the elimination of omeprazole, a potent inhibitor of gastric acid secretion, was studied in the isolated perfused rat liver." | 3.67 | Effect of hypoxia on oxidative and reductive pathways of omeprazole metabolism by the isolated perfused rat liver. ( Jones, DB; Mihaly, GW; Morgan, DJ; Smallwood, RA; Webster, LK, 1985) |
"In mice, changes of body temperature and concentration of lactic acid in the blood were studied after three modes of barochamber hypoxia (altitude 8000 m) at the temperatures +10, +20 and +36 degrees C." | 3.67 | [Effect of short-term hypoxia on body temperature and lactic acid in the blood of the mouse]. ( Pisarenko, SN; Sepisheva, AS; Slonim, AD, 1985) |
"The possibility of detecting past hypoxia during the first 2 h after birth by means of blood analyses of hypoxanthine, lactate, base deficit, and pH was investigated in six infants with a 1 min Apgar score of less than or equal to 4." | 3.66 | Hypoxanthine as a test of perinatal hypoxia as compared to lactate, base deficit, and pH. ( Bratteby, LE; Swanström, S, 1982) |
" Alterations in coronary flow were induced by hypoxia, amobarbital (Amytal) infusion, increase in work load of the heart, and adenosine infusion." | 3.66 | Role of mitochondrial oxidative phosphorylation in regulation of coronary blood flow. ( Erecińska, M; Nishiki, K; Nuutinen, EM; Wilson, DF, 1982) |
" A diagnosis of idiopathic lactic acidosis was established when the arterial blood pH was found to be 6." | 3.64 | THE CLINICAL SIGNIFICANCE OF ELEVATED BLOOD LACTATE. ( PHILLIPSON, EA; SPROULE, BJ, 1965) |
" Future studies should focus on potential dose-response effects and the involved mechanisms." | 3.30 | Repeated Short-Term Bouts of Hyperoxia Improve Aerobic Performance in Acute Hypoxia. ( Dünnwald, T; Faulhaber, M; Gatterer, H; Kennedy, MD; Menz, V; Rausch, LK; Schneider, S; Schobersberger, W, 2023) |
"Currently, hypothermia is the only approved clinical treatment available for HIE." | 3.01 | Exogenous lactate administration: A potential novel therapeutic approach for neonatal hypoxia-ischemia. ( Deng, Q; Duan, R; Liu, TC; Wu, C; Yang, L, 2023) |
"Lactate acidosis is often observed in the tumor microenvironment (TME) of solid tumors." | 3.01 | Lactate acidosis and simultaneous recruitment of TGF-β leads to alter plasticity of hypoxic cancer cells in tumor microenvironment. ( Arora, MK; Banerjee, S; Kaithwas, G; Mishra, SS; Rastogi, S; Ravichandiran, V; Roy, S; Singh, L, 2023) |
"Hypoxemia is readily detectable by assessing SpO2 levels, and these are important in optimizing COVID-19 patient management." | 3.01 | Longitudinal Monitoring of Lactate in Hospitalized and Ambulatory COVID-19 Patients. ( Gabor, J; Kieu Linh, LT; Kreidenweiss, A; Kremsner, PG; Krishna, S; Velavan, TP, 2021) |
"Compared to normoxemia, hypoxemia did not significantly modify the resting concentrations of TBARS and RAA, and did not affect the consumption of ascorbic acid after 60% MVC but suppressed the post-exercise TBARS increase." | 2.70 | Acute hypoxemia does not increase the oxidative stress in resting and contracting muscle in humans. ( Dousset, E; Faucher, M; Jammes, Y; Steinberg, JG, 2002) |
"Glycogenolysis was lower with DCA, resulting in reduced lactate concentration ([lactate]), despite similar phosphorylase a mole fractions and posttransformational regulators." | 2.69 | Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia. ( Heigenhauser, GJ; Hollidge-Horvat, MG; Hultman, E; Jones, NL; Matsos, MP; Parolin, ML; Spriet, LL, 2000) |
"1." | 2.68 | The effect of altitude hypoxia on glucose homeostasis in men. ( Dela, F; Galbo, H; Hansen, JM; Larsen, JJ; Olsen, NV, 1997) |
"Global metabolism of cancers exhibits a peculiar phenotype that is lactate acidosis (high lactate with acidic pH) in tumor microenvironment." | 2.61 | Lactate as a signaling molecule: Journey from dead end product of glycolysis to tumor survival. ( Chhonker, SK; Koiri, RK; Mehrotra, A; Naik, RA; Rawat, D; Trigun, SK, 2019) |
"Early-onset hyperlactatemia is that which develops in the operating room or very early following intensive care unit (ICU) admission." | 2.55 | Hyperlactatemia and Cardiac Surgery. ( Minton, J; Sidebotham, DA, 2017) |
"Although interest in lactate for cancer development only appeared recently, pharmacological molecules blocking its metabolism are already in phase I/II clinical trials." | 2.53 | Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters. ( Marchiq, I; Pouysségur, J, 2016) |
"Inflammation is an important component of normal responses to infection and injury." | 2.49 | Metabolomics--a novel window into inflammatory disease. ( Fitzpatrick, M; Young, SP, 2013) |
"Before heating, locally advanced cervical cancers are mostly hypoxic, acidic, exhibit substrate and energy deprivation and show lactate accumulation, which is spatially and temporally heterogeneous." | 2.48 | Blood flow and associated pathophysiology of uterine cervix cancers: characterisation and relevance for localised hyperthermia. ( Kelleher, DK; Vaupel, PW, 2012) |
"DC have been shown to infiltrate many tumors but both, circulating and tumor-infiltrating DC from cancer patients, appear to be phenotypically and functionally defective." | 2.44 | Tumor-induced modulation of dendritic cell function. ( Gottfried, E; Kreutz, M; Mackensen, A, 2008) |
"During prolonged anoxia at low temperature, freshwater turtles develop high plasma concentrations of both lactate and calcium." | 2.42 | Surviving extreme lactic acidosis: the role of calcium lactate formation in the anoxic turtle. ( Jackson, DC, 2004) |
"This is also true for patients in septic shock after plasma volume expansion." | 2.39 | [Is infection and septic shock caused by a global oxygen deficiency? An overview in 2 parts. 1: Infection and correlation between DO2 and VO2]. ( Ensinger, H; Georgieff, M, 1996) |
"Under high-altitude hypoxia environment, the body is more prone to fatigue, which occurs in both peripheral muscles and the central nervous system (CNS)." | 1.91 | Monocarboxylate transporter-dependent mechanism is involved in the adaptability of the body to exercise-induced fatigue under high-altitude hypoxia environment. ( Gao, C; Li, Y; Pei, W; Yang, B, 2023) |
"This study demonstrates that acute high altitude hypoxia upregulated the lactic acid/amino acid-pyruvate-TCA pathways and fatty acid oxidation, but downregulated glycolysis in the liver of mice." | 1.91 | Energy metabolic mechanisms for high altitude sickness: Downregulation of glycolysis and upregulation of the lactic acid/amino acid-pyruvate-TCA pathways and fatty acid oxidation. ( Jiang, C; Li, Y; Liao, N; Liu, G; Shang, X; Shao, D; Shi, J; Xu, F; Yin, D, 2023) |
"Solid tumors have developed robust ferroptosis resistance." | 1.91 | HIF-1α drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1. ( Guan, Q; Qin, C; Qu, S; Su, W; Wang, Y; Wei, X; Xiang, J; Yang, Z; Yao, B; Zen, K; Zhao, D; Zhou, J, 2023) |
" In our study, patients were administered a daily dosage of 2 × 600 mg of diosmin for 3 months, and we evaluated several factors associated with oxygen management, angiogenesis, and inflammation using biochemical assays." | 1.91 | Effect of Diosmin on Selected Parameters of Oxygen Homeostasis. ( Dresler, S; Feldo, M; Płachno, BJ; Samborski, D; Sowa, I; Sowa, P; Wójciak, M, 2023) |
"During intervertebral disc degeneration (IVDD), due to endplate calcification, diminished oxygen and nutrient concentrations and accumulated lactate are present in the microenvironment of the nucleus pulposus (NP)." | 1.72 | Monocarboxylate transporter 1-mediated lactate accumulation promotes nucleus pulposus degeneration under hypoxia in a 3D multilayered nucleus pulposus degeneration model. ( Bit, A; Hsieh, MK; Hu, YJ; Lai, PL; Wang, CY, 2022) |
"Hypoxia is a common concern in shrimp aquaculture, affecting growth and survival." | 1.72 | Changes in metabolic profiling of whiteleg shrimp (Penaeus vannamei) under hypoxic stress. ( Alfaro, AC; Bayot, B; Nguyen, TV; Rodríguez, J; Sonnenholzner, S, 2022) |
"Gestational hypoxemia is often associated with reduced birth weight, yet how hypoxemia controls uteroplacental nutrient metabolism and supply to the fetus is unclear." | 1.62 | Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia. ( Brown, LD; Jones, AK; Julian, CG; Limesand, SW; Lorca, RA; Moore, LG; Rozance, PJ; Wesolowski, SR, 2021) |
"NIP2;1 expression is limited to the "anoxia core" region of the root stele under normal growth conditions, but shows substantial induction (up to 1,000-fold by 2-4 h of hypoxia) by low oxygen stress, and accumulation in all root tissues." | 1.62 | Aquaporin family lactic acid channel NIP2;1 promotes plant survival under low oxygen stress in Arabidopsis. ( Beamer, ZG; Choi, WG; Lokdarshi, A; Roberts, DM; Routray, P; Spangler, MK, 2021) |
"Melanoma is the most lethal of all skin-related cancers with incidences continuously rising." | 1.62 | In Vitro Evaluation of CD276-CAR NK-92 Functionality, Migration and Invasion Potential in the Presence of Immune Inhibitory Factors of the Tumor Microenvironment. ( Baden, C; Chan, KC; Grote, S; Handgretinger, R; Mezger, M; Schleicher, S; Ureña-Bailén, G, 2021) |
"Hypoxia and inflammation are hallmarks of critical illness, related to multiple organ failure." | 1.62 | Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males. ( Bergmans, DCJJ; Driessen, RGH; Gerretsen, J; Kiers, D; Kox, M; Pickkers, P; Schalkwijk, CG; Scheijen, JLJM; van Bussel, BCT; van de Poll, MCG; van der Horst, ICC, 2021) |
"Hypovolemia was induced and maintained for 20 min by removal of 50% of the total blood volume; thereafter, the animals were retransfused." | 1.56 | Altered Cerebral Blood Flow and Potential Neuroprotective Effect of Human Relaxin-2 (Serelaxin) During Hypoxia or Severe Hypovolemia in a Sheep Model. ( Bischoff, SJ; Irintchev, A; Lehmann, T; Lemke, C; Nistor, M; Schiffner, R; Schmidt, M, 2020) |
"In solid tumors, hypoxia can trigger aberrant expression of transcription factors and genes, resulting in abnormal biological functions such as altered energetic pathways in cancer cells." | 1.56 | Computational modeling to determine key regulators of hypoxia effects on the lactate production in the glycolysis pathway. ( Hashemzadeh, S; Omidi, Y; Rafii-Tabar, H; Shahmorad, S, 2020) |
"IDH1 mutant gliomas have distinct metabolic and microenvironment characteristics compared with wild type gliomas." | 1.51 | Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI. ( Chakhoyan, A; Cloughesy, TF; Ellingson, BM; Everson, RG; Lai, A; Liau, LM; Mareninov, S; Nathanson, DA; Nghiemphu, PL; Pope, WB; Prins, RM; Raymond, C; Salamon, N; Yao, J; Yong, WH, 2019) |
"Ischemia was followed by a significant increase in muscle myeloperoxidase activity, as well as interleukin-6 and thiobarbituric acid reactive substances species levels." | 1.48 | N-acetylcysteine effects on a murine model of chronic critical limb ischemia. ( Constantino, L; da Silva, LA; Dal-Pizzol, F; Dall'Igna, DM; de Medeiros, WA; Dos Santos Cardoso, J; Manfredini, A; Michels, M; Ritter, C; Scaini, G; Streck, EL; Vuolo, F, 2018) |
"Cholesteatoma has attracted many studies seeking to uncover its nature and the pathogenesis of related diseases." | 1.48 | Comparison of changes in mitochondrial bioenergetics between keratinocytes in human external auditory canal skin and cholesteatomas from normoxia to hypoxia. ( Chen, HC; Chen, HK; Chen, YT; Kuo, CY; Lee, JT; Lin, YC; Lin, YY; Shih, CP; Wang, CH, 2018) |
"We suspect that exercise-induced hypoxemia occurring during running could be at the origin of the RBC rheological behavior differences with cycling." | 1.48 | Eryptosis and hemorheological responses to maximal exercise in athletes: Comparison between running and cycling. ( Connes, P; Fort, R; Germain, M; Guillot, N; Hancco, I; Joly, P; Lavorel, L; Nader, E; Renoux, C; Stauffer, E, 2018) |
"Hypoxemia is one of the most common pathological processes in various clinical diseases." | 1.48 | High-performance reoxygenation from PLGA-PEG/PFOB emulsions: a feedback relationship between ROS and HIF-1α. ( He, D; Huang, G; Li, N; Shen, X; Wang, J; Wang, R; Zhu, J, 2018) |
"Unearthing embryology-like processes in tumors may allow us to control organ-like tumor features such as tissue repair and revascularization and treat intratumoral heterogeneity." | 1.46 | Metabolic origins of spatial organization in the tumor microenvironment. ( Akkari, L; Carmona-Fontaine, C; Deforet, M; Joyce, JA; Thompson, CB; Xavier, JB, 2017) |
"Recent research suggest that anoxia-tolerant fish transfer extracellular nitrite into the tissues, where it is used for nitric oxide (NO) generation, iron-nitrosylation, and S-nitrosation of proteins, as part of the cytoprotective response toward prolonged hypoxia and subsequent reoxygenation." | 1.43 | Nitric oxide availability in deeply hypoxic crucian carp: acute and chronic changes and utilization of ambient nitrite reservoirs. ( Gerber, L; Hansen, MN; Jensen, FB, 2016) |
"After 1 week of anoxia, a major part of the glycogen stores was mobilized in liver (79." | 1.43 | Glycogen dynamics of crucian carp (Carassius carassius) in prolonged anoxia. ( Haverinen, J; Vornanen, M, 2016) |
"Exercise-induced arterial hypoxemia (EIAH) is often found in endurance-trained subjects at high exercise intensity." | 1.42 | Exercise effects on erythrocyte deformability in exercise-induced arterial hypoxemia. ( Alis, R; Blesa, JR; Ferioli, D; La Torre, A; Romagnoli, M; Sanchis-Gomar, F, 2015) |
"With intermittent anoxia, the pattern of substrate effects on the NAP changed markedly so that low concentrations of fructose became able to support neurophysiologic activity but not high concentrations of glucose." | 1.42 | Anoxia-induced changes in optimal substrate for peripheral nerve. ( Stecker, MM; Stevenson, MR, 2015) |
"BxPC-3 pancreatic cancer cells were cultured under hypoxic conditions and treated with or without the nanoparticles." | 1.42 | PLGA/poloxamer nanoparticles loaded with EPAS1 siRNA for the treatment of pancreatic cancer in vitro and in vivo. ( Fang, W; Li, K; Li, L; Pan, X; Sun, Y; Zhao, Z; Zhu, Q; Zhu, Y; Zuo, J, 2015) |
"High uric acid (UA) has been found to be correlated with renal dysfunction in some experimental and clinical studies; however, the study of the dynamic correlation between AKI and UA in severe burns is still lacking." | 1.42 | Elevated serum uric acid after injury correlates with the early acute kidney in severe burns. ( Hu, X; Liang, J; Zhang, P; Zhi, L, 2015) |
"Acute mountain sickness is caused by sub-acute hypoxia in healthy individuals going rapidly to altitude." | 1.39 | The antioxidative effect of a novel free radical scavenger 4'-hydroxyl-2-substituted phenylnitronyl nitroxide in acute high-altitude hypoxia mice. ( Fan, PC; Jia, ZP; Jing, LL; Li, L; Ma, HP, 2013) |
"While respiratory alkalosis occurred in patients with better preservation of FEV1, respiratory acidosis was observed with more severe airway obstruction, as was increased lactate in the majority of patients, independent of PaO(2) and PaCO(2) levels." | 1.39 | Acid-base patterns in acute severe asthma. ( Adrogué, HJ; Gonzalez, S; Menga, G; Raimondi, GA; Zaltsman, J, 2013) |
"We have shown earlier that breast cancer cells secrete higher levels of interleukin-6 (IL-6) under hypoxia, leading to the recruitment of hMSCs towards hypoxic tumor cells." | 1.38 | Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment. ( Ackerstaff, E; Banerjee, D; Glod, JW; Koutcher, JA; Patel, BB; Rattigan, YI; Sukenick, G, 2012) |
"Only 65% of patients with septic shock had hyperlactataemia at the onset of shock and 76% of these also had a high lactate/pyruvate ratio." | 1.38 | Lactate/pyruvate ratio as a marker of tissue hypoxia in circulatory and septic shock. ( Bruzzi de Carvahlo, F; Cotton, F; De Backer, D; Orellano-Jimenez, C; Rimachi, R; Vincent, JL, 2012) |
"However, EPAOC after 36 h of anoxia could not account for RMR being maintained." | 1.37 | Anoxic survival of the Pacific hagfish (Eptatretus stoutii). ( Cox, GK; Farrell, AP; Richards, JG; Sandblom, E, 2011) |
"Histamine was released during hypoxia and reoxygenation and also reperfusion, as was tryptase β, and high concentrations of adenosine (>1 µmol litre⁻¹, hypoxia group) and inosine (> 7 µmol litre⁻¹, ischaemia group) were measured in effluent (P < 0." | 1.37 | Shedding of the coronary endothelial glycocalyx: effects of hypoxia/reoxygenation vs ischaemia/reperfusion. ( Annecke, T; Becker, BF; Conzen, P; Fischer, J; Hartmann, H; Rehm, M; Sommerhoff, CP; Tschoep, J, 2011) |
"Chuvash polycythemia (CP) is an autosomal recessive human disorder in which the regulatory degradation of HIF is impaired, resulting in elevated levels of HIF at normal oxygen tensions." | 1.36 | Regulation of human metabolism by hypoxia-inducible factor. ( Cheeseman, J; Clarke, K; Constantin-Teodosiu, D; Dorrington, KL; Edwards, LM; Emmanuel, Y; Formenti, F; Frayn, KN; Greenhaff, PL; Humphreys, SM; Karpe, F; Lappin, TR; McMullin, MF; McNamara, CJ; Mills, W; Murphy, JA; O'Connor, DF; Percy, MJ; Ratcliffe, PJ; Robbins, PA; Smith, TG; Treacy, M, 2010) |
"Insulin sensitivity was assessed using the euglycemic clamp before and after the exposures." | 1.35 | Effects of acute intermittent hypercapnic hypoxia on insulin sensitivity in piglets using euglycemic clamp. ( Aouad, LJ; Tam, K; Waters, KA, 2008) |
"Nutritional interventions for intrauterine growth restriction (IUGR) have raised concerns for fetal toxicity, the mechanisms of which are unknown." | 1.35 | Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction. ( Barry, JS; Brown, LD; Hay, WW; Limesand, SW; Rozance, PJ, 2009) |
"SRBD patients had obstructive sleep apnea syndrome with or without sleep-related hypoventilation/hypoxemic conditions." | 1.35 | Nocturnal hypoxia and arterial lactate levels in sleep-related breathing disorders. ( Erbaycu, AE; Guclu, SZ; Kirakli, C; Taymaz, Z; Tuksavul, F; Ucar, ZZ, 2009) |
"During septic shock, muscle produces lactate by way of an exaggerated NaK-adenosine triphosphatase (ATPase)-stimulated aerobic glycolysis associated with epinephrine stimulation possibly through beta2 adrenoreceptor involvement." | 1.35 | Increased aerobic glycolysis through beta2 stimulation is a common mechanism involved in lactate formation during shock states. ( Desebbe, O; Gibot, S; Levy, B; Montemont, C, 2008) |
"Moreover, the stimulatory effect of anoxia on glycolytic flux was inversely correlated to the relative reliance on aerobic glycolysis." | 1.35 | Aerobic glycolysis in cancers: implications for the usability of oxygen-responsive genes and fluorodeoxyglucose-PET as markers of tissue hypoxia. ( Busk, M; Bussink, J; Horsman, MR; Kristjansen, PE; Overgaard, J; van der Kogel, AJ, 2008) |
"For each measurement, the more anoxia-tolerant species (painted turtle, Chrysemys picta; snapping turtle, Chelydra serpentina) had higher values than the less anoxia-tolerant species (musk turtle, Sternotherus odoratus; map turtle, Graptemys geographica; red-eared slider, Trachemys scripta)." | 1.34 | Comparative shell buffering properties correlate with anoxia tolerance in freshwater turtles. ( Asare, VS; Gall, JM; Jackson, DC; Reese, SA; Taylor, SE; Villarnovo, D, 2007) |
"Muscle lactate formation in endotoxic shock was further inhibited by intravenous infusion of ICI-118551 or dichloroacetate (DCA), an activator of pyruvate dehydrogenase (DCA) and their combination." | 1.34 | Myocardial lactate deprivation is associated with decreased cardiovascular performance, decreased myocardial energetics, and early death in endotoxic shock. ( Gibot, S; Lacolley, P; Lecompte, T; Levy, B; Mallie, JP; Mansart, A; Montemont, C; Regnault, V, 2007) |
"Muscles utilize glycogen during anoxia more at warmer temperatures." | 1.34 | Effects of temperature on anoxic submergence: skeletal buffering, lactate distribution, and glycogen utilization in the turtle, Trachemys scripta. ( Jackson, DC; Warren, DE, 2007) |
"We assessed the anoxia tolerance of A." | 1.34 | Extreme anoxia tolerance in embryos of the annual killifish Austrofundulus limnaeus: insights from a metabolomics analysis. ( Fan, TW; Higashi, R; Lopez, JP; Podrabsky, JE; Somero, GN, 2007) |
" The fatigue task altered the dose-response relationship to intramuscular acidic saline injections." | 1.34 | Muscle fatigue increases the probability of developing hyperalgesia in mice. ( Lisi, TL; Moore, SA; Sluka, KA; Yokoyama, T, 2007) |
"After a stabilization period, prolonged hypoxemia (FiO(2): 0." | 1.33 | Excitatory amino acid release and electrocortical brain activity after hypoxemia in near-term lambs. ( Hopman, J; Ruitenbeek, W; van de Bor, M; van Os, S, 2006) |
"Neonatal anoxia was induced by placing 2-day-old rat pups into a glass chamber with 100% N(2) atmosphere, T=36." | 1.33 | Selected biochemical variables in a model of neonatal anoxia in rats. ( Dubovický, M; Mach, M; Navarová, J; Schmidtová, M; Ujházy, E, 2006) |
"Hemorrhagic shock was induced in 48 anesthetized rats by withdrawing 28 mL/kg blood." | 1.33 | Fluid resuscitation with hemoglobin-vesicle solution does not increase hypoxia or inflammatory responses in moderate hemorrhagic shock. ( Goto, Y; Horinouchi, H; Miyashita, M; Sakai, H; Sakamoto, A; Terajima, K; Tsuchida, E; Tsueshita, T, 2006) |
"Our data also suggest that chronic hypoxemia depresses mechanosensitive muscle afferents." | 1.32 | Comparison between the effects of chronic and acute hypoxemia on muscle afferent activities from the tibialis anterior muscle. ( Decherchi, P; Dousset, E; Grelot, L; Jammes, Y, 2003) |
"Acute hypoxemia was subsequently induced in all fetuses by reducing maternal fractional inspired oxygen concentration for 1 h." | 1.32 | Hindlimb glucose and lactate metabolism during umbilical cord compression and acute hypoxemia in the late-gestation ovine fetus. ( Fowden, AL; Gardner, DS; Giussani, DA, 2003) |
"Postmortem hypoxemia was induced by cervical dislocation." | 1.32 | The contribution of glycolytic and oxidative pathways to retinal photoreceptor function. ( Bui, BV; Kalloniatis, M; Vingrys, AJ, 2003) |
"Compared with a control group, COPD patients had lower MVCs, an attenuated decrease in MF during exercise, lower resting level of GSH, no posthandgrip TBARS increase and no GSH consumption." | 1.32 | Influence of chronic hypoxemia on peripheral muscle function and oxidative stress in humans. ( Barbier, D; Faucher, M; Hug, F; Jammes, Y; Steinberg, JG, 2004) |
"Adenosine is a product of adenylate phosphate breakdown that can exert protective effects on tissues during energy limitation." | 1.32 | Cardiorespiratory and tissue adenosine responses to hypoxia and reoxygenation in the short-horned sculpin Myoxocephalus scorpius. ( Driedzic, WR; Maccormack, TJ, 2004) |
"After 60 min of anoxia, stage 27HH hearts did not retrieve their baseline activity." | 1.31 | Developmental changes in cardiac recovery from anoxia-reoxygenation. ( Kucera, P; Raddatz, E; Sedmera, D, 2002) |
"During hypoxemia, both the pretreatment with endotoxin and nicotine induced higher levels of extracellular lactate and peak lactate/pyruvate ratio compared with controls (54." | 1.31 | Detrimental effects of nicotine and endotoxin in the newborn piglet brain during severe hypoxemia. ( Amerio, G; Frøen, JF; Saugstad, OD; Stray-Pedersen, B, 2002) |
"In painted turtles anoxia induced a significant increase in myocardial HSP72/73 (from 2." | 1.31 | Expression of heat shock proteins in turtle and mammal hearts: relationship to anoxia tolerance. ( Chang, J; Knowlton, AA; Wasser, JS, 2000) |
"With hypoxemia, time had a significant effect on V(O2) and body temperature in an age-dependent fashion: that is, whereas the 1 week group and the 4-5 week group showed both variables decreasing over time, the 2-3 week group showed no drop in V(O2) and a small increase in body temperature over time." | 1.31 | Age-dependent metabolic effects of repeated hypoxemia in piglets. ( Barter, J; Côté, A; Meehan, B, 2000) |
"Shell and bone ¿Na(+) both fell during anoxia but the fate of this Na(+) is uncertain because plasma ¿Na(+) also fell." | 1.31 | Bone and shell contribution to lactic acid buffering of submerged turtles Chrysemys picta bellii at 3 degrees C. ( Crocker, CE; Jackson, DC; Ultsch, GR, 2000) |
"cylindriformis, survives anoxia for only 2 days at 25 degrees C." | 1.31 | Anoxia tolerance of con-familial tiger beetle larvae is associated with differences in energy flow and anaerobiosis. ( Hand, SC; Higley, LG; Hoback, WW; Podrabsky, JE; Stanley, DW, 2000) |
"Severe hypoxemia induces similar alterations of renal excretion in newborn piglets." | 1.31 | Effect of severe normocapnic hypoxia on renal function in growth-restricted newborn piglets. ( Bauer, R; Walter, B; Zwiener, U, 2000) |
"Although arterial hypoxemia developed during the second run, arterial PO2 values were significantly (P < 0." | 1.31 | Effect of prior high-intensity exercise on exercise-induced arterial hypoxemia in Thoroughbred horses. ( Goetz, TE; Hassan, AS; Manohar, M, 2001) |
"Furthermore, at 15 degrees C anoxia reduced the ATP turnover rate to 50% of the normoxic rate." | 1.30 | Energy turnover in the normoxic and anoxic turtle heart. ( Arthur, PG; Cousins, KL; Farrell, AP; Franklin, CE; Hochachka, PW; Thorarensen, H, 1997) |
"Progressive graded hypoxemia was induced by decreasing fractional inspiratory oxygen concentration (FIO2) from 1." | 1.30 | Mixed venous oxygen saturation and biochemical parameters of hypoxia during progressive hypoxemia in 10- to 14-day-old piglets. ( Blanco, CE; Maertzdorf, WJ; van der Hoeven, MA, 1997) |
"Many enzyme activities in Alzheimer's disease (AD) are changed." | 1.30 | Affected enzyme activities in Alzheimer's disease are sensitive to antemortem hypoxia. ( Bothmer, J; Jolles, J; Meng, F; Terwel, D; Wolf, E, 1998) |
"Lactic acid production was also significantly suppressed in the subzero nonfreezing group compared with that in the control group." | 1.30 | Subzero nonfreezing storage of isolated rat hepatocytes in University of Wisconsin solution. ( Matsuda, H; Matsuoka, J; Tanaka, N; Yagi, T; Yamamura, H, 1999) |
"When hearts could adjust their HR, hypoxemia demanded more energy than ischemia (p < 0." | 1.29 | Effects of energy demand in ischemic and in hypoxemic isolated rat hearts. ( Allibardi, S; Casalini, S; Corno, A; Samaja, M, 1994) |
"Hindlimb O2 transport decreased with hypoxemia, but O2 consumption remained unchanged in both groups." | 1.29 | Hydroxymalonate inhibits lactate uptake by the rabbit hindlimb. ( Arbelaez, G; Chakravarthy, S; Fernandez, E; Gutierrez, G; Hurtado, FJ; Kiiski, R; Ronco, JJ, 1994) |
"To evaluate the effect of hypoxemia on cardiac release of neuropeptide Y-like immunoreactivity (NPY-LI) and norepinephrine (NE), arterial and coronary sinus blood was sampled and coronary sinus blood flow was measured by thermodilution in nine healthy volunteers at rest and during supine cycle ergometer exercise while they breathed air and 12% O2, which reduced arterial O2 saturation to approximately 68%." | 1.29 | Neuropeptide Y release from human heart is enhanced during prolonged exercise in hypoxia. ( Berglund, B; Grubbström, J; Kaijser, L; Lundberg, JM; Pernow, J, 1994) |
"Glycogen depletion by anoxia or glucagon before ischemia impaired recovery." | 1.29 | Metabolic recovery of isolated working rat heart after brief global ischemia. ( Goodwin, GW; Taegtmeyer, H, 1994) |
"Ipsilateral testicular torsion causes a decrease not only in the ipsilateral torted but also in the contralateral nontorted testicular perfusion." | 1.29 | Ipsilateral and contralateral testicular biochemical acute changes after unilateral testicular torsion and detorsion. ( Akgür, FM; Büyükpamukçu, N; Hiçsönmez, A; Kilinç, K; Tanyel, FC, 1994) |
"Maternal hypoxemia resulted in no change in fetal mixed arterio-venous pH (7." | 1.29 | Cerebral energy metabolism in fetal guinea pigs during moderate maternal hypoxemia at 0.75 of gestation. ( Berger, R; Jensen, A; Krieglstein, J; Steigelmann, JP, 1993) |
"Induced hypoxemia resulted in a variable degree of fetal acidemia that was entirely metabolic." | 1.29 | Cerebral metabolism during sustained hypoxemia in preterm fetal sheep. ( Asano, H; Carmichael, L; Homan, J; Korkola, S; Richardson, B, 1994) |
"Induced fetal hypoxemia resulted in a lactic metabolic acidosis that progressively worsened, with death occurring in three of the animals during the early recovery period." | 1.29 | Recovery of the ovine fetus from sustained hypoxia: effects on endocrine, cardiovascular, and biophysical activity. ( Carmichael, L; Fraher, L; Matsuda, Y; Patrick, J; Richardson, B, 1994) |
"During anoxia we measured a four- to sixfold increase of the interstitial lactate concentration." | 1.29 | Interstitial lactate and glucose concentrations of the isolated perfused rat heart before, during and after anoxia. ( Kammermeier, H; Strupp, M, 1993) |
"The present study used a model of cardiac tamponade to investigate the effects of endotoxin on the oxygen extraction capabilities of the body during an acute reduction in blood flow, when blood volume and arterial oxygen content were maintained." | 1.29 | Oxygen extraction is altered by endotoxin during tamponade-induced stagnant hypoxia in the dog. ( Vincent, JL; Zhang, H, 1993) |
"During anoxia all 14C remained in the animal indicating no urine production." | 1.29 | Lactate distribution and metabolism during and after anoxia in the turtle, Chrysemys picta bellii. ( Jackson, DC; Okamoto, S; Toney, VI, 1996) |
"After 45 min of anoxia, total lactate production was less in immature tubules (101 +/- 48 micrograms of lactate/mg of DNA) compared with mature tubules (148 +/- 36 micrograms of lactate/mg of DNA)." | 1.29 | Glycolysis is not responsible for the tolerance of immature renal tubules to anoxia. ( Gaudio, KM; Siegel, NJ; Thulin, G, 1996) |
"Exposure to 30 h anoxia resulted in significant increases in the activities of skeletal muscle and heart catalase (by 53 and 47%), heart and brain glutathione peroxidase (by 75 and 30%), and brain glutathione S-transferase (by 66%)." | 1.29 | Relationship between anoxia exposure and antioxidant status in the frog Rana pipiens. ( Hermes-Lima, M; Storey, KB, 1996) |
"During hypoxemia, pressure dropped initially, as observed during ischemia." | 1.29 | Dynamics of myocardial adaptation to low-flow ischemia and hypoxemia. ( Allibardi, S; de Jong, JW; Merati, G; Monti, LD; Samaja, M, 1996) |
"Induced fetal hypoxemia resulted in a progressive lactic metabolic acidosis; however, all fetuses had recovered within 24 hours." | 1.28 | Effects of sustained hypoxemia on the sheep fetus at midgestation: endocrine, cardiovascular, and biophysical responses. ( Carmichael, L; Challis, J; Matsuda, Y; Patrick, J; Richardson, B, 1992) |
"Lactate formation at the onset of anoxia is proportional to stimulus frequency." | 1.28 | ATP formation and energy demand in anoxic heart muscle of the rabbit. ( Dietrich, DL; Elzinga, G, 1992) |
"To test the hypothesis that long-term hypoxemia affects fetal cardiac function, we measured right (RVO) and left (LVO) ventricular output by electromagnetic flow probes." | 1.28 | Right and left ventricular function in fetal sheep exposed to long-term high-altitude hypoxemia. ( Gilbert, RD; Kamitomo, M; Longo, LD, 1992) |
"In contrast to the hepatoma cells, rat and human hepatocytes exhibited higher rates of anaerobic glycolysis in the presence of fructose and thus were able to maintain their viability under these conditions." | 1.28 | Differences in glycolytic capacity and hypoxia tolerance between hepatoma cells and hepatocytes. ( Anundi, I; de Groot, H; Hugo-Wissemann, D; Lauchart, W; Viebahn, R, 1991) |
"During CO2 acidosis, anoxia had no effect on apparent nonbicarbonate buffer value (d[HCO3-]/dpHi = 71 and 89 mM/pH in normoxia and anoxia, respectively) or on pHi regulation (dpHi/dpHe = 0." | 1.28 | 31P-NMR study of normoxic and anoxic perfused turtle heart during graded CO2 and lactic acidosis. ( Arendt, EA; Inman, KC; Jackson, DC; Lawler, RG; Panol, G; Wasser, JS, 1991) |
"Arterial hypoxemia decreased epicardial tissue PO2, measured by means of a multiwire surface electrode, as well as coronary venous PO2 and myocardial lactate extraction." | 1.28 | Epicardial oxygen tensions during changes in arterial PO2 in pigs. ( Baier, H; Brendel, W; Christ, M; Conzen, PF; Goetz, A; Habazettl, H; Peter, K; Vollmar, B, 1990) |
"During anoxia, hyperglycemic cats showed higher brain lactate levels (26 versus 20 mumol/g), but similar ATP and phosphocreatine concentrations, compared with normoglycemic cats." | 1.28 | Delayed neurologic deterioration following anoxia: brain mitochondrial and metabolic correlates. ( Kleinholz, M; Myers, RE; Wagner, KR, 1989) |
"Ischemia and anoxia were induced in the area perfused by the distal left anterior descending artery in 32 mongrel dogs." | 1.27 | Different effects of acute ischemia and anoxia on the canine myocardium. ( Hattori, S; Mori, H; Nagata, M; Nakamura, Y; Sakurai, K; Takahashi, M, 1984) |
"During lung anoxia produced by ventilation with CO, glucose utilization and lactate production were again markedly decreased by addition of lactate (2 mM) to the perfusate." | 1.27 | Lactate and regulation of lung glycolytic rate. ( Dodia, C; Fisher, AB, 1984) |
"The periods of hypoxemia and ischemia lasted 56." | 1.27 | Bioenergetics of rabbit skeletal muscle during hypoxemia and ischemia. ( Andry, JM; Gutierrez, G; Narayana, P; Pohil, RJ; Strong, R, 1988) |
"The effects of prolonged mild hypoxemia on the fetus have received little attention." | 1.27 | The effect of mild hypoxemia maintained for twenty-four hours on maternal and fetal glucose, lactate, cortisol, and arginine vasopressin in pregnant sheep at 122 to 139 days' gestation. ( Elias, B; Figueroa, J; Markowitz, S; Nathanielsz, P; Towell, ME, 1987) |
"When the hypoxemia-induced reduction in O2 consumption was less than 15% of the baseline value (at fractional concentration of inspired oxygen 0." | 1.27 | Oxygen transport and metabolism in the conscious lamb: the effects of hypoxemia. ( Lister, G; Moreau, G; Moss, M, 1987) |
"To examine the effects of hypoxemia on carbohydrate and O2 consumption by the fetal kidney, we inserted catheters into the descending aorta, inferior vena cava, and left renal vein of 14 fetal sheep at 120-130 days gestation." | 1.27 | Metabolic responses of the kidney in fetal sheep: effect of acute and spontaneous hypoxemia. ( Iwamoto, HS; Rudolph, AM, 1985) |
"After 15 min of hypoxemia we repeated the measurements." | 1.26 | Fetal myocardial oxygen and carbohydrate consumption during acutely induced hypoxemia. ( Fisher, DJ; Heymann, MA; Rudolph, AM, 1982) |
"Total lactate rose during anoxia to a mean peak value of 145 mM, but the decrease in HCO-3 and Cl- and increase in K+ balanced less than 40% of the lactate." | 1.26 | Plasma ion balance of submerged anoxic turtles at 3 degrees C: the role of calcium lactate formation. ( Heisler, N; Jackson, DC, 1982) |
"The effect of temperature, either along or in combination with pentobarbital or phenytoin, on survival time in the hypoxic (Flo2 = 0." | 1.26 | Influence of hypothermia or hyperthermia alone or in combination with pentobarbital or phenytoin on survival time in hypoxic mice. ( Artru, AA; Michenfelder, JD, 1981) |
"We conclude that with progressive hypoxemia, CMRO2 remains stable until oxygen demand exceeds oxygen delivery, resulting thereafter in a progressive reduction in CMRO2." | 1.26 | Canine cerebral metabolism and blood flow during hypoxemia and normoxic recovery from hypoxemia. ( Artru, AA; Michenfelder, JD, 1981) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 142 (15.57) | 18.7374 |
1990's | 206 (22.59) | 18.2507 |
2000's | 254 (27.85) | 29.6817 |
2010's | 218 (23.90) | 24.3611 |
2020's | 92 (10.09) | 2.80 |
Authors | Studies |
---|---|
Jones, AK | 1 |
Rozance, PJ | 2 |
Brown, LD | 2 |
Lorca, RA | 1 |
Julian, CG | 1 |
Moore, LG | 1 |
Limesand, SW | 3 |
Wesolowski, SR | 1 |
Flores-Sauceda, M | 1 |
Camacho-Jiménez, L | 1 |
Peregrino-Uriarte, AB | 1 |
Leyva-Carrillo, L | 1 |
Arvizu-Flores, A | 1 |
Yepiz-Plascencia, G | 1 |
Dennis, MC | 1 |
Goods, PSR | 1 |
Binnie, MJ | 1 |
Girard, O | 4 |
Wallman, KE | 1 |
Dawson, B | 3 |
Billaut, F | 2 |
Peeling, P | 3 |
Yamagata, K | 2 |
Zúñiga, A | 1 |
Camacho, M | 1 |
Chang, HJ | 1 |
Fristot, E | 1 |
Mayonove, P | 1 |
Hani, EH | 1 |
Bonnet, J | 1 |
Beamer, ZG | 1 |
Routray, P | 1 |
Choi, WG | 2 |
Spangler, MK | 1 |
Lokdarshi, A | 1 |
Roberts, DM | 2 |
Huynh, KW | 1 |
Pamenter, ME | 1 |
Wang, CY | 1 |
Hsieh, MK | 1 |
Hu, YJ | 1 |
Bit, A | 1 |
Lai, PL | 1 |
Sumartiningsih, S | 1 |
Rahayu, S | 1 |
Handoyo, E | 1 |
Lin, JC | 1 |
Lim, CL | 1 |
Starczewski, M | 1 |
Fuchs, PX | 1 |
Kuo, CH | 2 |
Wang, Z | 1 |
Li, H | 1 |
Wang, H | 3 |
Li, X | 4 |
Zhang, Q | 3 |
Li, K | 2 |
Qiu, Y | 1 |
Baryła, I | 1 |
Styczeń-Binkowska, E | 1 |
Płuciennik, E | 1 |
Kośla, K | 1 |
Bednarek, AK | 1 |
Sinenchenko, A | 1 |
Lodyagin, A | 1 |
Loladze, A | 1 |
Batotsyrenov, B | 1 |
Antonova, A | 1 |
Kovalenko, A | 1 |
Jena, BC | 1 |
Das, CK | 1 |
Banerjee, I | 1 |
Bharadwaj, D | 1 |
Majumder, R | 1 |
Das, S | 1 |
Biswas, A | 1 |
Kundu, M | 1 |
Roy, PK | 1 |
Kundu, CN | 1 |
Mandal, M | 1 |
Morris, NL | 1 |
Michael, DN | 1 |
Crotty, KM | 1 |
Chang, SS | 1 |
Yeligar, SM | 1 |
Daboss, EV | 1 |
Tikhonov, DV | 1 |
Shcherbacheva, EV | 1 |
Karyakin, AA | 1 |
Pouysségur, J | 2 |
Marchiq, I | 2 |
Parks, SK | 1 |
Durivault, J | 1 |
Ždralević, M | 1 |
Vucetic, M | 1 |
Öğünç Keçeci, Y | 1 |
İncesu, Z | 1 |
Nguyen, TV | 1 |
Alfaro, AC | 1 |
Rodríguez, J | 1 |
Bayot, B | 1 |
Sonnenholzner, S | 1 |
Liu, S | 2 |
Zhao, H | 1 |
Hu, Y | 3 |
Yan, C | 1 |
Mi, Y | 1 |
Tao, D | 1 |
Qin, J | 1 |
Kennedy, L | 1 |
Glesaaen, ER | 1 |
Palibrk, V | 1 |
Pannone, M | 1 |
Wang, W | 2 |
Al-Jabri, A | 1 |
Suganthan, R | 1 |
Meyer, N | 2 |
Austbø, ML | 1 |
Lin, X | 2 |
Bergersen, LH | 2 |
Bjørås, M | 1 |
Rinholm, JE | 1 |
Xu, Z | 1 |
Dai, X | 1 |
Chen, L | 2 |
Cheng, Z | 1 |
Lin, H | 1 |
Zhou, Z | 1 |
Guo, Z | 1 |
Yang, Y | 4 |
Li, L | 7 |
Zhao, Q | 2 |
Li, Y | 5 |
Liu, Z | 1 |
Hao, L | 1 |
Guo, B | 1 |
Diao, A | 1 |
Afzal, J | 3 |
Suhail, Y | 3 |
Chang, H | 3 |
Hubbi, ME | 3 |
Hamidzadeh, A | 3 |
Goyal, R | 3 |
Liu, Y | 8 |
Sun, P | 3 |
Nicoli, S | 3 |
Dang, CV | 3 |
Levchenko, A | 3 |
Sun, L | 2 |
Gao, W | 3 |
Liu, J | 4 |
Wang, J | 7 |
Yu, H | 2 |
Xu, ZP | 2 |
Goldberg, FW | 2 |
Kettle, JG | 2 |
Lamont, GM | 2 |
Buttar, D | 2 |
Ting, AKT | 2 |
McGuire, TM | 2 |
Cook, CR | 2 |
Beattie, D | 2 |
Morentin Gutierrez, P | 2 |
Kavanagh, SL | 2 |
Komen, JC | 2 |
Kawatkar, A | 2 |
Clark, R | 2 |
Hopcroft, L | 2 |
Hughes, G | 2 |
Critchlow, SE | 2 |
Ruan, S | 1 |
Yin, W | 1 |
Chang, J | 2 |
Sun, J | 1 |
Ma, X | 1 |
Zang, J | 1 |
Ren, T | 1 |
Dong, H | 1 |
Raberin, A | 1 |
Willis, SJ | 2 |
Richard, T | 1 |
Elmer, J | 1 |
Vernillo, G | 1 |
Iaia, FM | 1 |
Malatesta, D | 1 |
Millet, GP | 4 |
Yang, L | 3 |
Gilbertsen, A | 1 |
Xia, H | 1 |
Benyumov, A | 1 |
Smith, K | 1 |
Herrera, J | 1 |
Racila, E | 1 |
Bitterman, PB | 1 |
Henke, CA | 1 |
Fan, M | 1 |
Yang, K | 1 |
Wang, X | 5 |
Gill, PS | 1 |
Ha, T | 1 |
Liu, L | 1 |
Lewis, NH | 1 |
Williams, DL | 1 |
Li, C | 2 |
Gao, C | 2 |
Yang, B | 2 |
Pei, W | 2 |
Jiang, T | 1 |
Liang, YS | 1 |
Gu, Y | 1 |
Yao, FC | 1 |
Liu, YF | 2 |
Zhang, KX | 1 |
Song, FB | 1 |
Sun, JL | 2 |
Luo, J | 2 |
Todorova, V | 1 |
Stauffacher, MF | 1 |
Ravotto, L | 1 |
Nötzli, S | 1 |
Karademir, D | 1 |
Ebner, LJA | 1 |
Imsand, C | 1 |
Merolla, L | 1 |
Hauck, SM | 1 |
Samardzija, M | 1 |
Saab, AS | 1 |
Barros, LF | 1 |
Weber, B | 1 |
Grimm, C | 1 |
Shi, ZB | 1 |
Ruan, QQ | 1 |
Geng, YN | 1 |
Cheng, X | 1 |
Zhao, M | 1 |
Zhu, LL | 1 |
Deng, Q | 1 |
Wu, C | 1 |
Liu, TC | 1 |
Duan, R | 1 |
Liu, G | 2 |
Liao, N | 1 |
Shang, X | 1 |
Xu, F | 1 |
Yin, D | 1 |
Shao, D | 1 |
Jiang, C | 2 |
Shi, J | 1 |
Yan, K | 1 |
He, Q | 1 |
Lin, D | 1 |
Liang, J | 2 |
Chen, J | 2 |
Xie, Z | 1 |
Chen, Z | 1 |
Yang, Z | 2 |
Su, W | 1 |
Wei, X | 1 |
Qu, S | 1 |
Zhao, D | 1 |
Zhou, J | 1 |
Wang, Y | 5 |
Guan, Q | 1 |
Qin, C | 1 |
Xiang, J | 1 |
Zen, K | 1 |
Yao, B | 1 |
Filippi, L | 1 |
Pascarella, F | 1 |
Pini, A | 1 |
Cammalleri, M | 1 |
Bagnoli, P | 1 |
Morganti, R | 1 |
Innocenti, F | 1 |
Castagnini, N | 1 |
Melosi, A | 1 |
Scaramuzzo, RT | 1 |
Rastogi, S | 1 |
Mishra, SS | 1 |
Arora, MK | 1 |
Kaithwas, G | 1 |
Banerjee, S | 1 |
Ravichandiran, V | 1 |
Roy, S | 1 |
Singh, L | 1 |
Centner, FS | 1 |
Schoettler, JJ | 1 |
Brohm, K | 1 |
Mindt, S | 1 |
Jäger, E | 1 |
Hahn, B | 1 |
Fuderer, T | 1 |
Lindner, HA | 1 |
Schneider-Lindner, V | 1 |
Krebs, J | 1 |
Neumaier, M | 1 |
Thiel, M | 1 |
Feldo, M | 1 |
Wójciak, M | 1 |
Dresler, S | 1 |
Sowa, P | 1 |
Płachno, BJ | 1 |
Samborski, D | 1 |
Sowa, I | 1 |
Paganini, M | 1 |
Moon, RE | 1 |
Giacon, TA | 1 |
Cialoni, D | 1 |
Martani, L | 1 |
Zucchi, L | 1 |
Garetto, G | 1 |
Talamonti, E | 1 |
Camporesi, EM | 1 |
Bosco, G | 1 |
Nho, RS | 1 |
Rice, C | 1 |
Prasad, J | 1 |
Bone, H | 1 |
Farkas, L | 1 |
Rojas, M | 1 |
Horowitz, JC | 1 |
Faulhaber, M | 8 |
Schneider, S | 1 |
Rausch, LK | 1 |
Dünnwald, T | 3 |
Menz, V | 4 |
Gatterer, H | 8 |
Kennedy, MD | 1 |
Schobersberger, W | 1 |
Yan, W | 1 |
Lv, Q | 1 |
Miao, Y | 1 |
Wei, Z | 1 |
Tian, Q | 1 |
Li, J | 2 |
Wu, B | 2 |
Xiao, Q | 1 |
Tian, N | 1 |
Yi, L | 1 |
Luo, M | 1 |
Li, Z | 2 |
Pang, Y | 2 |
Shi, X | 1 |
Dong, Z | 1 |
Gnocchi, D | 1 |
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Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Study on the Diagnostic Value of Multi-omics Combined Detection for Precancerous Lesions of Colorectal Cancer[NCT05530746] | 500 participants (Anticipated) | Observational | 2022-05-01 | Recruiting | |||
An Open-label, Multi-center, Phase 1b Study to Investigate the Safety and Tolerability of SLC-0111 (WBI-5111) in Combination With Gemcitabine in Metastatic Pancreatic Ductal Adenocarcinoma Subjects Positive for Carbonic Anhydrase IX[NCT03450018] | Phase 1/Phase 2 | 30 participants (Anticipated) | Interventional | 2019-01-10 | Recruiting | ||
An Observational Cohort Study to Validate SEARCH, a Novel Hierarchical Algorithm to Define Long-term Outcomes After Pulmonary Embolism[NCT05568927] | 150 participants (Anticipated) | Observational | 2022-11-01 | Enrolling by invitation | |||
Mean Arterial Pressure (MAP) Trial: Study Protocol for a Multicenter, Randomized, Controlled Trial to Compare Three Different Strategies of Mean Arterial Pressure Management During Cardiopulmonary By-pass[NCT05740397] | 900 participants (Anticipated) | Interventional | 2021-05-03 | Recruiting | |||
Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)[NCT05120284] | Phase 2 | 40 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
Renal Effects of Erythropoietin in Humans[NCT01584921] | Phase 1 | 16 participants (Actual) | Interventional | 2012-03-31 | Completed | ||
Effects of Endogenous Iron Status and Intravenous Iron on Human Skeletal Muscle Metabolism at Rest and During Exercise[NCT02308449] | 29 participants (Actual) | Interventional | 2014-10-31 | Completed | |||
Using the ΔvapCO2 / Cav02 Ratio as a Prognostic Marker and Predictor of Complications After Cardiac Surgery[NCT02876406] | 150 participants (Anticipated) | Observational [Patient Registry] | 2016-10-31 | Recruiting | |||
Peripheral Perfusion Versus Lactate Targeted Fluid Resuscitation in Septic Shock: ANDROMEDA-SHOCK PHYSIOLOGY STUDY[NCT03762005] | 46 participants (Anticipated) | Interventional | 2018-06-01 | Recruiting | |||
Brain During Effort : Effects of Hypoxia With Respiratory Patients[NCT02854280] | 33 participants (Actual) | Interventional | 2013-06-30 | Completed | |||
Agreement Between Arterial, Central Venous, and Peripheral Venous Lactate in the Intensive Care Unit[NCT01624519] | 50 participants (Anticipated) | Interventional | 2012-08-31 | Not yet recruiting | |||
Remote Ischemic Conditioning as a Treatment for Traumatic Brain Injury: a Prospective Randomized Controlled Trial.[NCT03176823] | 40 participants (Anticipated) | Interventional | 2019-05-03 | Recruiting | |||
Markers of Tissue Perfusion as Predictors of Complicated Evolution in Patients With Left Ventricular Dysfunction Submitted to Coronary Artery Bypass Surgery[NCT01178866] | 87 participants (Actual) | Observational | 2006-01-31 | Completed | |||
Effect of Exercise-induced Hypoxemia on Cytokine and Stress Hormone Responses Among Endurance-trained Athletes[NCT04305873] | 50 participants (Anticipated) | Observational | 2020-03-01 | Enrolling by invitation | |||
Resuscitation Failure, Protein Carbonyl and Receptor Interacting Protein Kinase 3 as Mortality Predictor in Septic Patient[NCT04169412] | 72 participants (Actual) | Observational [Patient Registry] | 2019-02-22 | Completed | |||
"Influence of High Vitamin C Dose on Lactate During Extracorporeal Circulation for Heart Surgery and During the 24 Hours Thereafter. (Double Blind Prospective Randomised Study)"[NCT04046861] | 200 participants (Anticipated) | Interventional | 2023-02-01 | Not yet recruiting | |||
Effectiveness of Chest Compressions Under Mild Hypoxia: Should Rescuers Breathe Supplemental Oxygen on Commercial Flights?[NCT04072484] | 19 participants (Actual) | Interventional | 2019-08-16 | Terminated (stopped due to Research at the University of Chicago was halted in March 2020.) | |||
Cardiovascular and Metabolic Physiological Adaptations to Intermittent Hypoxia. Physiological Aspects and Expression of Receptors and Cellular Mediators[NCT02058823] | Phase 4 | 12 participants (Actual) | Interventional | 2013-08-07 | Terminated (stopped due to budget constraints) | ||
The Insulin Sensitivity Using Aerobic Interval Conditioning[NCT01286922] | 42 participants (Actual) | Interventional | 2009-07-31 | Completed | |||
Near-infrared Spectroscopic Measurement of Tissue Oxygen Saturation and the Vascular Occlusion Test in Complex Regional Pain Syndrome[NCT01586377] | 20 participants (Actual) | Observational | 2011-08-31 | Completed | |||
Long-term Oxygen Therapy in Patients With Chronic Obstructive Pulmonary Disease (COPD) Who Live at High Altitude (2640 Meters Above Sea Level): Evaluation of a Proposal for Adjusting Criteria[NCT03020212] | 220 participants (Anticipated) | Interventional | 2016-02-29 | Recruiting | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
55 reviews available for lactic acid and Anoxemia
Article | Year |
---|---|
Lactate Supply from Astrocytes to Neurons and its Role in Ischemic Stroke-induced Neurodegeneration.
Topics: Animals; Astrocytes; Hypoxia; Ischemic Stroke; Lactic Acid; Neurons | 2022 |
'Warburg effect' controls tumor growth, bacterial, viral infections and immunity - Genetic deconstruction and therapeutic perspectives.
Topics: Animals; Bacteria; Cell Line, Tumor; Humans; Hypoxia; Lactic Acid; Monocarboxylic Acid Transporters; | 2022 |
Exogenous lactate administration: A potential novel therapeutic approach for neonatal hypoxia-ischemia.
Topics: Humans; Hypothermia; Hypothermia, Induced; Hypoxia; Hypoxia-Ischemia, Brain; Infant, Newborn; Ischem | 2023 |
Lactate acidosis and simultaneous recruitment of TGF-β leads to alter plasticity of hypoxic cancer cells in tumor microenvironment.
Topics: Acidosis; Humans; Hypoxia; Lactic Acid; Neoplasms; Transforming Growth Factor beta; Tumor Microenvir | 2023 |
L-lactic acidosis: pathophysiology, classification, and causes; emphasis on biochemical and metabolic basis.
Topics: Acidosis, Lactic; Anions; Bicarbonates; Citric Acid Cycle; Critical Illness; Electron Transport Chai | 2020 |
Hyperlactatemia: An Update on Postoperative Lactate.
Topics: Acidosis, Lactic; Biomarkers; Cardiac Surgical Procedures; Female; Humans; Hyperlactatemia; Hypoxia; | 2020 |
Astrocytic nutritional dysfunction associated with hypoxia-induced neuronal vulnerability in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Astrocytes; Cell Death; Cells, Cultured; Humans; Hypertension; Hypoxia; Lactic Acid; Neuron | 2020 |
Practical Management of ECPELLA.
Topics: Acidosis; Assisted Circulation; Combined Modality Therapy; Extracorporeal Membrane Oxygenation; Femo | 2020 |
Quantitative Assessment of Blood Lactate in Shock: Measure of Hypoxia or Beneficial Energy Source.
Topics: Animals; Critical Illness; Disease Models, Animal; Dogs; Humans; Hypoxia; Lactic Acid; Liver; Models | 2020 |
Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance.
Topics: Amino Acids; Animals; Citric Acid Cycle; Dimerization; Disease Progression; Drug Resistance, Neoplas | 2020 |
The role of lactate in sepsis and COVID-19: Perspective from contracting skeletal muscle metabolism.
Topics: Adrenergic Agents; COVID-19; Humans; Hypoxia; Lactate Dehydrogenases; Lactic Acid; Muscle, Skeletal; | 2022 |
Exercise during short-term exposure to hypoxia or hyperoxia - novel treatment strategies for type 2 diabetic patients?!
Topics: Diabetes Mellitus, Type 2; Exercise Therapy; Glucose; Humans; Hyperoxia; Hypoxia; Insulin Resistance | 2018 |
Lactate metabolism: historical context, prior misinterpretations, and current understanding.
Topics: Astrocytes; Energy Metabolism; Exercise; Humans; Hypoxia; Lactic Acid; Neurons | 2018 |
Lactate as a signaling molecule: Journey from dead end product of glycolysis to tumor survival.
Topics: Cell Hypoxia; Cell Line, Tumor; Cell Survival; Glycolysis; Humans; Hydrogen-Ion Concentration; Hypox | 2019 |
The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression.
Topics: Adenosine Triphosphate; Animals; Biomass; Cell Line, Tumor; Cell Proliferation; Cellular Reprogrammi | 2019 |
Hypoxia, lactate accumulation, and acidosis: siblings or accomplices driving tumor progression and resistance to therapy?
Topics: Acidosis; Disease Progression; Drug Resistance, Neoplasm; Humans; Hypoxia; Lactic Acid; Neoplasms | 2013 |
Lactate or ScvO2 as an endpoint in resuscitation of shock states?
Topics: Endpoint Determination; Humans; Hypoxia; Lactic Acid; Oxygen; Prognosis; Resuscitation; Shock; Shock | 2013 |
Lactate and the injured brain: friend or foe?
Topics: Brain Injuries; Cerebral Cortex; Cerebrovascular Circulation; Energy Metabolism; Female; Glycolysis; | 2014 |
Analysis of hypoxia-induced metabolic reprogramming.
Topics: Autophagy; Carbon Isotopes; Cell Culture Techniques; Culture Media; Glucose; Glycolysis; Humans; Hyd | 2014 |
Metabolic aspects of high-altitude adaptation in Tibetans.
Topics: Adaptation, Physiological; Altitude; Basic Helix-Loop-Helix Transcription Factors; Energy Metabolism | 2015 |
Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters.
Topics: Animals; Antineoplastic Agents; Basigin; Biomarkers; Energy Metabolism; Humans; Hypoxia; Lactic Acid | 2016 |
Performance Enhancement: What Are the Physiological Limits?
Topics: Acclimatization; Adaptation, Physiological; Altitude; Anaerobic Threshold; Exercise; Humans; Hypoxia | 2015 |
The Kenyan runners.
Topics: Ammonia; Arteries; Athletic Performance; Humans; Hypoxia; Kenya; Lactic Acid; Lung; Muscle, Skeletal | 2015 |
Cerebral Lactate Metabolism After Traumatic Brain Injury.
Topics: Animals; Brain Injuries; Cerebrovascular Circulation; Glucose; Humans; Hypoxia; Lactic Acid; Neuropr | 2016 |
Hyperlactatemia and Cardiac Surgery.
Topics: Acidosis, Lactic; Biomarkers; Cardiac Surgical Procedures; Humans; Hyperlactatemia; Hypoxia; Lactic | 2017 |
The anti-oxidant capacity of tumour glycolysis.
Topics: Animals; Antioxidants; DNA Damage; Glycolysis; Humans; Hypoxia; Lactic Acid; Luminescent Measurement | 2009 |
Hypoxia-inducible factors and their roles in energy metabolism.
Topics: Animals; Carbohydrate Metabolism; Energy Metabolism; Humans; Hypoxia; Hypoxia-Inducible Factor 1; La | 2012 |
Blood flow and associated pathophysiology of uterine cervix cancers: characterisation and relevance for localised hyperthermia.
Topics: Animals; Cervix Uteri; Female; Glucose; Humans; Hyperthermia, Induced; Hypoxia; Lactic Acid; Uterine | 2012 |
Endothelial cell metabolism and tumour angiogenesis: glucose and glutamine as essential fuels and lactate as the driving force.
Topics: Angiogenesis Inhibitors; Endothelial Cells; Endothelium, Vascular; Glucose; Glutamine; Glycolysis; H | 2013 |
Metabolomics--a novel window into inflammatory disease.
Topics: Animals; Biomarkers; Energy Metabolism; Humans; Hypoxia; Inflammation; Lactic Acid; Metabolomics; Me | 2013 |
Cellular pathophysiology. Part 2: Responses following hypoxia.
Topics: Blood Volume; Calcium; Cell Membrane; Cell Physiological Phenomena; Energy Metabolism; Free Radicals | 2003 |
Performing at extreme altitude: muscle cellular and subcellular adaptations.
Topics: Acclimatization; Adult; Altitude; Atmospheric Pressure; Body Weight; Citrate (si)-Synthase; Electron | 2003 |
Acid-base balance at exercise in normoxia and in chronic hypoxia. Revisiting the "lactate paradox".
Topics: Acid-Base Equilibrium; Adenosine Triphosphate; Energy Metabolism; Exercise; Glycolysis; Homeostasis; | 2003 |
Limiting factors to oxygen transport on Mount Everest 30 years after: a critique of Paolo Cerretelli's contribution to the study of altitude physiology.
Topics: Acclimatization; Altitude; Arteries; Atmospheric Pressure; Capillaries; Cardiac Output; Cardiovascul | 2003 |
Arterial desaturation during exercise in man: implication for O2 uptake and work capacity.
Topics: Adolescent; Adult; Aged; Animals; Blood Gas Analysis; Cardiovascular Physiological Phenomena; Child; | 2003 |
Acid-base balance during hypoxic hypometabolism: selected vertebrate strategies.
Topics: Acclimatization; Acid-Base Equilibrium; Animals; Carbon Dioxide; Environment; Fishes; Hydrogen-Ion C | 2004 |
Surviving extreme lactic acidosis: the role of calcium lactate formation in the anoxic turtle.
Topics: Acidosis, Lactic; Adaptation, Physiological; Animals; Bone and Bones; Calcium; Calcium Compounds; Hu | 2004 |
Bench-to-bedside review: oxygen debt and its metabolic correlates as quantifiers of the severity of hemorrhagic and post-traumatic shock.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Disease Models, Animal; Dogs; Humans; Hypovolemia; Hypoxia | 2005 |
Lactate as a marker of energy failure in critically ill patients: hypothesis.
Topics: Acid-Base Equilibrium; Biomarkers; Critical Care; Critical Illness; Disease Progression; Energy Meta | 2005 |
Lactate and shock state: the metabolic view.
Topics: Humans; Hypoxia; Lactic Acid; Shock | 2006 |
Lactate and shock state: the metabolic view.
Topics: Humans; Hypoxia; Lactic Acid; Shock | 2006 |
Lactate and shock state: the metabolic view.
Topics: Humans; Hypoxia; Lactic Acid; Shock | 2006 |
Lactate and shock state: the metabolic view.
Topics: Humans; Hypoxia; Lactic Acid; Shock | 2006 |
Fundamentals of oxygen delivery.
Topics: Biological Transport; Energy Metabolism; Humans; Hypoxia; Lactic Acid; Lung; Mitochondria; Oxygen | 2007 |
Lactate metabolism in anoxic turtles: an integrative review.
Topics: Adaptation, Physiological; Animals; Hypoxia; Lactic Acid; Turtles | 2008 |
Tumor-induced modulation of dendritic cell function.
Topics: Animals; Cell Differentiation; Cyclooxygenase 2; Dendritic Cells; Dinoprostone; Humans; Hypoxia; Lac | 2008 |
A reexamination of the role of oxygen in retrolental fibroplasia.
Topics: Anencephaly; Apnea; Carbon Dioxide; Cerebral Hemorrhage; Ductus Arteriosus, Patent; Exchange Transfu | 1984 |
Potassium loss during myocardial ischaemia and hypoxia: does lactate efflux play a role?
Topics: Biological Transport; Cell Membrane; Humans; Hypoxia; Lactates; Lactic Acid; Myocardial Ischemia; My | 1994 |
[Is infection and septic shock caused by a global oxygen deficiency? An overview in 2 parts. 1: Infection and correlation between DO2 and VO2].
Topics: Acid-Base Equilibrium; Cardiac Output; Humans; Hypoxia; Lactates; Lactic Acid; Oxygen; Oxygen Consum | 1996 |
Lactate during exercise at high altitude.
Topics: Acclimatization; Altitude; Biological Transport, Active; Glycogen; Glycolysis; Humans; Hypoxia; Lact | 1996 |
Is the maximal accumulated oxygen deficit an adequate measure of the anaerobic capacity?
Topics: Anaerobic Threshold; Anaerobiosis; Exercise; Humans; Hypoxia; Lactic Acid; Muscle, Skeletal; Oxygen | 1996 |
Brain anaerobic lactate production: a suicide note or a survival kit?
Topics: Anaerobiosis; Animals; Brain; Brain Ischemia; Energy Metabolism; Hypoxia; Lactic Acid | 1998 |
[Clinical evaluation and methodological aspects of serum lactate].
Topics: Biomarkers; Humans; Hypoxia; Lactic Acid | 1999 |
Lactate is an unreliable indicator of tissue hypoxia in injury or sepsis.
Topics: Cell Hypoxia; Humans; Hypoxia; Lactic Acid; Resuscitation; Sensitivity and Specificity; Systemic Inf | 1999 |
Lung injury and lactate production: a hypoxic stimulus?
Topics: Biomarkers; Humans; Hypoxia; Lactic Acid; Lung; Respiratory Distress Syndrome | 1999 |
Anaerobic performance at altitude.
Topics: Acclimatization; Altitude; Energy Metabolism; Exercise; Humans; Hypoxia; Lactates; Lactic Acid; Musc | 1992 |
Contact lens-induced corneal endothelial polymegathism: functional significance and possible mechanisms.
Topics: Actin Cytoskeleton; Biomechanical Phenomena; Calcium; Carbon Dioxide; Contact Lenses; Cornea; Cornea | 1986 |
Inflammation, glycolytic metabolism, and glycosaminoglycans.
Topics: Aerobiosis; Animals; Cell Division; Cells, Cultured; Glycolysis; Glycosaminoglycans; Hypoxia; Inflam | 1986 |
80 trials available for lactic acid and Anoxemia
Article | Year |
---|---|
Systemic Lactate Elevation Induced by Tobacco Smoking during Rest and Exercise Is Not Associated with Nicotine.
Topics: Adult; Carbon; Cross-Over Studies; Electronic Nicotine Delivery Systems; Humans; Hypoxia; Lactic Aci | 2022 |
Repeated Short-Term Bouts of Hyperoxia Improve Aerobic Performance in Acute Hypoxia.
Topics: Bicycling; Female; Humans; Hyperoxia; Hypoxia; Lactic Acid; Male; Oxygen | 2023 |
Sessional work-rate does not affect the magnitude to which simulated hypoxia can augment acute physiological responses during resistance exercise.
Topics: Exercise Tolerance; Heart Rate; Humans; Hypoxia; Lactic Acid; Male; Muscle, Skeletal; Oxygen Consump | 2020 |
Longitudinal Monitoring of Lactate in Hospitalized and Ambulatory COVID-19 Patients.
Topics: Adolescent; Adult; Ambulatory Care Facilities; Biomarkers; Comorbidity; COVID-19; Female; Germany; H | 2021 |
Four weeks of high-intensity training in moderate, but not mild hypoxia improves performance and running economy more than normoxic training in horses.
Topics: Animals; Biomarkers; Cardiorespiratory Fitness; Cross-Over Studies; Exercise Test; Exercise Toleranc | 2021 |
Blueberry supplementation reduces the blood lactate response to running in normobaric hypoxia but has no effect on performance in recreational runners.
Topics: Adult; Anthocyanins; Athletic Performance; Biomarkers; Blueberry Plants; Cross-Over Studies; Dietary | 2021 |
Normobaric hypoxia increases the growth hormone response to maximal resistance exercise in trained men.
Topics: Adult; Cross-Over Studies; Electromyography; Exercise; Heart Rate; Human Growth Hormone; Humans; Hyp | 2017 |
Changes in acid-base and ion balance during exercise in normoxia and normobaric hypoxia.
Topics: Acid-Base Equilibrium; Adult; Exercise; Humans; Hypoxia; Lactic Acid; Male; Oxygen | 2017 |
Acute effects of repeated cycling sprints in hypoxia induced by voluntary hypoventilation.
Topics: Adult; Bicycling; Hemoglobins; Humans; Hypoventilation; Hypoxia; Lactic Acid; Male; Myoglobin; Oxyge | 2017 |
Effect of high-intensity resistance circuit-based training in hypoxia on aerobic performance and repeat sprint ability.
Topics: Adult; Athletic Performance; Basal Metabolism; Energy Metabolism; Hemoglobins; High-Intensity Interv | 2018 |
Acute Effects of Interset Rest Duration on Physiological and Perceptual Responses to Resistance Exercise in Hypoxia.
Topics: Adult; Cross-Over Studies; Electromyography; Heart Rate; Humans; Hypoxia; Lactic Acid; Male; Myalgia | 2020 |
Bench press performance during an intermittent hypoxic resistance training to muscle failure.
Topics: Adult; Cross-Over Studies; Humans; Hypoxia; Lactic Acid; Male; Muscle Fatigue; Myalgia; Resistance T | 2019 |
Partial Range of Motion Exercise Is Effective for Facilitating Muscle Hypertrophy and Function Through Sustained Intramuscular Hypoxia in Young Trained Men.
Topics: Arm; Electromyography; Humans; Hypertrophy; Hypoxia; Lactic Acid; Male; Muscle Strength; Muscle Stre | 2019 |
Effects of oxytocin and carbetocin on farrowing performance.
Topics: Animals; Animals, Newborn; Female; Fetal Blood; Hypoxia; Lactic Acid; Oxytocics; Oxytocin; Parturiti | 2019 |
Ischemic Preconditioning Maintains Performance on Two 5-km Time Trials in Hypoxia.
Topics: Adult; Bicycling; Cross-Over Studies; Heart Rate; Humans; Hypoxia; Ischemic Preconditioning; Lactic | 2019 |
[Individual systemic reactions of human organism under acute hypoxia].
Topics: Adult; Blood Flow Velocity; Blood Glucose; Brain; Brain Waves; Cerebrovascular Circulation; Energy M | 2012 |
Effect of different simulated altitudes on repeat-sprint performance in team-sport athletes.
Topics: Acid-Base Equilibrium; Altitude; Athletic Performance; Biomarkers; Competitive Behavior; Group Proce | 2014 |
Effects of resistance training under hypoxic conditions on muscle hypertrophy and strength.
Topics: Biomarkers; Healthy Volunteers; Human Growth Hormone; Humans; Hypertrophy; Hypoxia; Lactic Acid; Mal | 2015 |
Effects of acute exposure to mild simulated hypoxia on hormonal responses to low-intensity resistance exercise in untrained men.
Topics: Adult; Biomarkers; Cross-Over Studies; Exercise; Healthy Volunteers; Human Growth Hormone; Humans; H | 2014 |
Impact of exercise and moderate hypoxia on glycemic regulation and substrate oxidation pattern.
Topics: Adult; Blood Glucose; Exercise; Fatty Acids, Nonesterified; Glycerol; Heart Rate; Humans; Hypoxia; I | 2014 |
Effect of Intermittent Hypoxic Training Followed by Intermittent Hypoxic Exposure on Aerobic Capacity of Long Distance Runners.
Topics: Adaptation, Physiological; Adult; Exercise Test; Exercise Tolerance; Female; Heart Rate; Humans; Hyp | 2016 |
Effect of repeat-sprint training in hypoxia on post-exercise interleukin-6 and F2-isoprostanes.
Topics: Adult; Altitude; F2-Isoprostanes; Heart Rate; Humans; Hypoxia; Inflammation; Interleukin-6; Lactic A | 2016 |
Seven Passive 1-h Hypoxia Exposures Do Not Prevent AMS in Susceptible Individuals.
Topics: Acclimatization; Adult; Altitude Sickness; Blood Gas Analysis; Double-Blind Method; Female; Heart Ra | 2016 |
Short-Term Hypoxic Exposure and Training Improve Maximal Anaerobic Running Test Performance.
Topics: Female; Humans; Hypoxia; Lactic Acid; Oxygen Consumption; Physical Endurance; Running; Young Adult | 2018 |
Biochemical responses and physical performance during high-intensity resistance circuit training in hypoxia and normoxia.
Topics: Adult; Anaerobic Threshold; Bicarbonates; Exercise Tolerance; High-Intensity Interval Training; Huma | 2017 |
Physiological Factors Associated With Declining Repeated Sprint Performance in Hypoxia.
Topics: Acceleration; Adult; Athletes; Athletic Performance; Cross-Over Studies; Exercise Test; Heart Rate; | 2019 |
High-intensity kayak performance after adaptation to intermittent hypoxia.
Topics: Adaptation, Physiological; Adolescent; Adult; Athletic Performance; Biomarkers; Cross-Over Studies; | 2006 |
Altitude hypoxia increases glucose uptake in human heart.
Topics: Adult; Altitude; Fluorodeoxyglucose F18; Glucose; Heart; Humans; Hypoxia; Lactic Acid; Male; Myocard | 2009 |
Cycling performance following adaptation to two protocols of acutely intermittent hypoxia.
Topics: Adaptation, Physiological; Adult; Bicycling; Confidence Intervals; Exercise Test; Heart Rate; Humans | 2009 |
The role of ribose on oxidative stress during hypoxic exercise: a pilot study.
Topics: Antioxidants; Bicycling; Cross-Over Studies; Dietary Carbohydrates; Dietary Supplements; Double-Blin | 2009 |
Acute altitude-induced hypoxia suppresses plasma glucose and leptin in healthy humans.
Topics: Adult; Altitude; Blood Glucose; C-Peptide; Epinephrine; Female; Glucose; Humans; Hypoxia; Insulin; I | 2010 |
Substrate utilization during exercise and recovery at moderate altitude.
Topics: Adult; Altitude; Anaerobic Threshold; Blood Glucose; Carbon Dioxide; Cardiovascular Physiological Ph | 2010 |
Training in normobaric hypoxia and its effects on acute mountain sickness after rapid ascent to 4559 m.
Topics: Acclimatization; Adult; Altitude Sickness; Blood Gas Analysis; Double-Blind Method; Female; Heart Ra | 2010 |
Exercise with hypoventilation induces lower muscle oxygenation and higher blood lactate concentration: role of hypoxia and hypercapnia.
Topics: Adult; Bicycling; Carbon Dioxide; Ear; Exercise; Hemoglobins; Humans; Hypercapnia; Hypoventilation; | 2010 |
Effects of erythropoietin administration on cerebral metabolism and exercise capacity in men.
Topics: Adolescent; Adult; Biomarkers; Blood Flow Velocity; Blood Glucose; Blood-Brain Barrier; Brain; Cereb | 2010 |
Blood lactate and pyruvate levels in the perioperative period of liver resection with Pringle maneuver.
Topics: Bile Ducts; Blood Loss, Surgical; Constriction; Female; Hepatectomy; Hepatic Artery; Humans; Hypoxia | 2010 |
Effect of intermittent hypoxia on muscle and cerebral oxygenation during a 20-km time trial in elite athletes: a preliminary report.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Carbon Dioxide; Cerebrovascular Circulation; Heart Rat | 2010 |
Intermittent exercise with and without hypoxia improves insulin sensitivity in individuals with type 2 diabetes.
Topics: Algorithms; Blood Glucose; Cross-Over Studies; Deuterium; Diabetes Mellitus, Type 2; Exercise; Gluco | 2012 |
The effects of hypoxia acclimation, exercise training and fasting on swimming performance in juvenile qingbo (Spinibarbus sinensis).
Topics: Acclimatization; Animals; Blood Glucose; Cyprinidae; Food Deprivation; Glycogen; Hypoxia; Lactic Aci | 2012 |
Four weeks of normobaric "live high-train low" do not alter muscular or systemic capacity for maintaining pH and K⁺ homeostasis during intense exercise.
Topics: Adult; Altitude; Bicarbonates; Carbon Dioxide; Double-Blind Method; Exercise; Exercise Test; Female; | 2012 |
Short-term supplementation with alpha-ketoglutaric acid and 5-hydroxymethylfurfural does not prevent the hypoxia induced decrease of exercise performance despite attenuation of oxidative stress.
Topics: Adult; Aldehydes; Altitude; Antioxidants; Athletic Performance; Double-Blind Method; Exercise; Exerc | 2013 |
Thigh oxygen uptake at the onset of intense exercise is not affected by a reduction in oxygen delivery caused by hypoxia.
Topics: Adult; Anaerobic Threshold; Analysis of Variance; Biopsy; Denmark; Double-Blind Method; Exercise; Ex | 2012 |
Acute hypoxemia does not increase the oxidative stress in resting and contracting muscle in humans.
Topics: Adult; Ascorbic Acid; Exercise Test; Humans; Hypoxia; Lactic Acid; Male; Muscle Contraction; Oxidati | 2002 |
Why is VO2 max after altitude acclimatization still reduced despite normalization of arterial O2 content?
Topics: Acclimatization; Acid-Base Equilibrium; Adult; Altitude; Blood Circulation; Blood Gas Analysis; Card | 2003 |
Effect of low oxygen inhalation on changes in blood pH, lactate, and ammonia due to exercise.
Topics: Adult; Ammonia; Anaerobic Threshold; Blood Chemical Analysis; Carbon Dioxide; Exercise; Humans; Hydr | 2004 |
Acute exposure to moderate high altitude decreases growth hormone response to physical exercise in untrained subjects.
Topics: Adult; Altitude; Exercise Test; Growth Hormone; Humans; Hypoxia; Insulin-Like Growth Factor I; Lacti | 2003 |
Does exercise-induced hypoxemia modify lactate influx into erythrocytes and hemorheological parameters in athletes?
Topics: Adaptation, Physiological; Adult; Blood Viscosity; Erythrocytes; Exercise Test; Hematocrit; Hemorheo | 2004 |
Effects of acute hypoxia on the estimation of lactate threshold from ventilatory gas exchange indices during an incremental exercise test.
Topics: Acute Disease; Adult; Anaerobic Threshold; Exercise Test; Humans; Hypoxia; Lactic Acid; Male; Oxygen | 2004 |
Individual variation in the reduction of heart rate and performance at lactate thresholds in acute normobaric hypoxia.
Topics: Adult; Altitude; Anaerobic Threshold; Exercise; Exercise Test; Heart Rate; Humans; Hypoxia; Lactic A | 2005 |
Effect of exercise intensity and hypoxia on skeletal muscle AMPK signaling and substrate metabolism in humans.
Topics: Adult; AMP-Activated Protein Kinases; Biopsy, Fine-Needle; Blood Glucose; Catecholamines; Energy Met | 2006 |
Effects of purified oxygenated water on exercise performance during acute hypoxic exposure.
Topics: Administration, Oral; Adult; Altitude; Bicycling; Blood Gas Analysis; Body Weight; Cross-Over Studie | 2005 |
Effects of exercise-induced arterial hypoxaemia on limb muscle fatigue and performance.
Topics: Adult; Arteries; Bicycling; Exercise; Humans; Hypoxia; Lactic Acid; Muscle Fatigue; Muscle, Skeletal | 2006 |
Effects of hypoxia on the onset of muscle deoxygenation and the lactate threshold.
Topics: Adult; Exercise; Female; Humans; Hypoxia; Lactic Acid; Male; Muscles; Oxygen; Oxygen Consumption; Sp | 2006 |
The effects of hyperthermia and hypoxia on ventilation during low-intensity steady-state exercise.
Topics: Adult; Body Temperature; Chemoreceptor Cells; Ergometry; Exercise; Fever; Hemoglobins; Humans; Hypox | 2007 |
The influence of acute and 23 days of intermittent hypoxic exposures on the exercise-induced forehead sweating response.
Topics: Acclimatization; Acute Disease; Adult; Altitude; Blood Pressure; Body Temperature Regulation; Chroni | 2007 |
Adjusting oxygen fraction to avoid hyperoxemia during cardiopulmonary bypass.
Topics: Administration, Inhalation; Blood Gas Analysis; Carbon Dioxide; Cardiopulmonary Bypass; Coronary Art | 2007 |
Does poor oxygenation during one-lung ventilation impair aerobic myocardial metabolism in patients with symptomatic coronary artery disease?
Topics: Aged; Anaerobic Threshold; Cardiopulmonary Bypass; Coronary Artery Bypass; Coronary Artery Disease; | 2007 |
GXT responses in altitude-acclimatized cyclists during sea-level simulation.
Topics: Acclimatization; Adult; Altitude; Bicycling; Colorado; Exercise; Exercise Test; Exhalation; Female; | 2007 |
The effect of intermittent hypobaric hypoxic exposure and sea level training on submaximal economy in well-trained swimmers and runners.
Topics: Acclimatization; Adult; Altitude; Double-Blind Method; Exercise; Female; Heart Rate; Humans; Hypoxia | 2008 |
Improved running economy and increased hemoglobin mass in elite runners after extended moderate altitude exposure.
Topics: Altitude; Australia; Biomechanical Phenomena; Heart Rate; Hemoglobins; Humans; Hypoxia; Lactic Acid; | 2009 |
[Young football players aerobic perfomance in sub-maximum exercise with exhaustion at a moderate altitude without acclimation: experience in El Condor].
Topics: Acclimatization; Adolescent; Altitude; Anaerobic Threshold; Argentina; Biomarkers; Blood Glucose; Bo | 2007 |
The ventilation, lactate and electromyographic thresholds during incremental exercise tests in normoxia, hypoxia and hyperoxia.
Topics: Adult; Anaerobic Threshold; Blood Gas Analysis; Carbon Dioxide; Chemoreceptor Cells; Electromyograph | 1994 |
Gas exchange, blood lactate, and plasma catecholamines during incremental exercise in hypoxia and normoxia.
Topics: Adult; Catecholamines; Exercise; Humans; Hypoxia; Lactates; Lactic Acid; Male; Oxygen Consumption; P | 1995 |
Effect of inspired O2 concentration on leg lactate release during incremental exercise.
Topics: Adult; Exercise; Exercise Test; Humans; Hypoxia; Lactic Acid; Leg; Male; Muscle, Skeletal; Oxygen Co | 1996 |
The effect of altitude hypoxia on glucose homeostasis in men.
Topics: Acclimatization; Adult; Altitude Sickness; Catecholamines; Exercise; Glucose; Glucose Clamp Techniqu | 1997 |
The serum interleukin 8 level reflects hepatic mitochondrial redox state in hyperthermochemohypoxic isolated liver perfusion with use of a venovenous bypass.
Topics: Aged; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Combined Modality Therapy; Fe | 1999 |
Intermittent hypobaric hypoxia induces altitude acclimation and improves the lactate threshold.
Topics: Acclimatization; Adult; Altitude Sickness; Anaerobic Threshold; Erythrocyte Count; Erythrocyte Indic | 2000 |
Effect of acute hypoxia on vasopressin release and intravascular fluid during dynamic exercise in humans.
Topics: Acute Disease; Adult; Arginine Vasopressin; Blood Gas Analysis; Blood Pressure; Body Water; Body Wei | 2000 |
Low-dose prostacyclin in treatment of severe brain trauma evaluated with microdialysis and jugular bulb oxygen measurements.
Topics: Adult; Aged; Biomarkers; Brain Injuries; Energy Metabolism; Epoprostenol; Female; Humans; Hypoxia; J | 2000 |
Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia.
Topics: Acetyl Coenzyme A; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Adult; Bl | 2000 |
Impaired interval exercise responses in elite female cyclists at moderate simulated altitude.
Topics: Acids; Altitude; Bicarbonates; Bicycling; Double-Blind Method; Exercise Test; Female; Heart Rate; Hu | 2000 |
Physical exercise and normobaric hypoxia: independent modulators of peripheral cholecystokinin metabolism in man.
Topics: Adult; Amino Acids, Branched-Chain; Anthropometry; Atmospheric Pressure; Blood Glucose; Cholecystoki | 2001 |
Physical training with and without oxygen in patients with chronic obstructive pulmonary disease and exercise-induced hypoxaemia.
Topics: Aged; Carbon Dioxide; Exercise; Exercise Test; Exercise Therapy; Female; Humans; Hypoxia; Lactic Aci | 2001 |
Increases in maximal accumulated oxygen deficit after high-intensity interval training are not gender dependent.
Topics: Adult; Body Composition; Body Height; Body Weight; Exercise; Exercise Test; Female; Heart Rate; Huma | 2002 |
The effect of sodium citrate intake on anaerobic performance in normoxia and after sudden ascent to a moderate altitude.
Topics: Adult; Altitude; Anaerobic Threshold; Citrates; Double-Blind Method; Exercise; Heart Rate; Humans; H | 2002 |
The influence of pacing strategy on VO2 and supramaximal kayak performance.
Topics: Adolescent; Adult; Competitive Behavior; Exercise; Humans; Hydrogen-Ion Concentration; Hypoxia; Lact | 2002 |
Exercise-induced oxyhaemoglobin desaturation, ventilatory limitation and lung diffusing capacity in women during and after exercise.
Topics: Adult; Arteries; Exercise; Exercise Test; Female; Humans; Hypoxia; Lactic Acid; Lung Volume Measurem | 2002 |
Metabolic aspects of acute tissue hypoxia during extracorporeal circulation and their modification induced by L-carnitine treatment.
Topics: Bicarbonates; Carnitine; Double-Blind Method; Extracorporeal Circulation; Female; Fumarates; Humans; | 1992 |
Effect of hypoxia on psychomotor performance during graded exercise.
Topics: Adult; Exercise; Heart Rate; Humans; Hypoxia; Lactates; Lactic Acid; Psychomotor Performance | 1991 |
Effect of dichloroacetate on ventilatory response to sustained hypoxia in normal adults.
Topics: Adult; Brain; Dichloroacetic Acid; Female; Humans; Hypoxia; Lactates; Lactic Acid; Male; Respiration | 1990 |
777 other studies available for lactic acid and Anoxemia
Article | Year |
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Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia.
Topics: Adaptation, Physiological; Amino Acids; AMP-Activated Protein Kinase Kinases; Animals; Female; Glyco | 2021 |
The bifunctional 6-phosphofructokinase-2/fructose-2,6-bisphosphatase from the shrimp Litopenaeus vannamei: Molecular characterization and down-regulation of expression in response to severe hypoxia.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Down-Regulation; Gene Expression Re | 2022 |
Increased air temperature during repeated-sprint training in hypoxia amplifies changes in muscle oxygenation without decreasing cycling performance.
Topics: Athletic Performance; Exercise; Hot Temperature; Humans; Hypoxia; Lactic Acid; Male; Muscle, Skeleta | 2023 |
Engineered l-Lactate Responding Promoter System Operating in Glucose-Rich and Anoxic Environments.
Topics: Biosensing Techniques; Gene Expression Regulation, Bacterial; Glucose; Humans; Hypoxia; Lactic Acid; | 2021 |
Aquaporin family lactic acid channel NIP2;1 promotes plant survival under low oxygen stress in Arabidopsis.
Topics: Adaptation, Physiological; Aquaporins; Arabidopsis; Gene Expression Regulation, Plant; Genes, Plant; | 2021 |
Lactate inhibits naked mole-rat cardiac mitochondrial respiration.
Topics: Adenosine Triphosphate; Animals; Cell Respiration; Hypoxia; Lactic Acid; Mitochondria, Heart; Mole R | 2022 |
Monocarboxylate transporter 1-mediated lactate accumulation promotes nucleus pulposus degeneration under hypoxia in a 3D multilayered nucleus pulposus degeneration model.
Topics: Glycosaminoglycans; Humans; Hypoxia; Intervertebral Disc Degeneration; Lactic Acid; Matrix Metallopr | 2022 |
TRIM72 exerts antitumor effects in breast cancer and modulates lactate production and MCT4 promoter activity by interacting with PPP3CA.
Topics: Breast Neoplasms; Calcineurin; Cell Line, Tumor; Cell Proliferation; Female; Humans; Hypoxia; Lactic | 2022 |
The
Topics: Animals; Down-Regulation; Glucose; Glycolysis; Humans; Hyperglycemia; Hypoxia; Hypoxia-Inducible Fac | 2022 |
[CLINICAL CASE OF ACUTE SEVERE COMBINED POISONING WITH NARCOTIC SUBSTANCES OF DEPENDENT AND PSYCHOSTIMULATING EFFECTS].
Topics: Adult; Coma; Cross Infection; Humans; Hypoxia; Lactic Acid; Methadone; Narcotics | 2022 |
TGF-β1 induced autophagy in cancer associated fibroblasts during hypoxia contributes EMT and glycolysis via MCT4 upregulation.
Topics: Animals; Autophagy; Cancer-Associated Fibroblasts; Gene Expression Regulation, Neoplastic; Glycolysi | 2022 |
Alcohol-Induced Glycolytic Shift in Alveolar Macrophages Is Mediated by Hypoxia-Inducible Factor-1 Alpha.
Topics: Animals; Ethanol; Glucose Transporter Type 1; Glycolysis; Hypoxia; Lactic Acid; Macrophages, Alveola | 2022 |
Ultrastable Lactate Biosensor Linearly Responding in Whole Sweat for Noninvasive Monitoring of Hypoxia.
Topics: Biosensing Techniques; Humans; Hypoxia; Lactic Acid; Sweat; Wearable Electronic Devices | 2022 |
Mitochondrial oxidative phosphorylation became functional under aglycemic hypoxia conditions in A549 cells.
Topics: A549 Cells; Adenosine Triphosphate; Cell Hypoxia; Citrate (si)-Synthase; Glucose; Glycolysis; Humans | 2022 |
Changes in metabolic profiling of whiteleg shrimp (Penaeus vannamei) under hypoxic stress.
Topics: Animals; Aquaculture; Biomarkers; Hypoxia; Lactic Acid; Penaeidae | 2022 |
Lactate promotes metastasis of normoxic colorectal cancer stem cells through PGC-1α-mediated oxidative phosphorylation.
Topics: Cell Line; Colorectal Neoplasms; Humans; Hypoxia; Lactic Acid; Neoplastic Stem Cells; Oxidative Phos | 2022 |
Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Brain; Hypoxia; Ischemia; Lactic Acid; Mice; Mice, Knockout; Microglia; N | 2022 |
Predicting postoperative hypoxemia risk factors in the patients after triple-branched stent graft implantation surgery with acute type A aortic dissection: A retrospective study.
Topics: Aortic Dissection; Creatinine; Humans; Hypoxia; Lactic Acid; Retrospective Studies; Risk Factors; St | 2022 |
Effects of Sports Functional Food on Physical Function of Athletes under Ultrasound Observation.
Topics: Animals; Antlers; Athletes; Deer; Functional Food; Hemoglobins; Humans; Hypoxia; Lactic Acid; Polyam | 2022 |
The novel prolyl hydroxylase-2 inhibitor caffeic acid upregulates hypoxia inducible factor and protects against hypoxia.
Topics: Animals; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Prolin | 2022 |
Lactate-dependent chaperone-mediated autophagy induces oscillatory HIF-1α activity promoting proliferation of hypoxic cells.
Topics: Cell Line, Tumor; Cell Proliferation; Chaperone-Mediated Autophagy; Humans; Hypoxia; Lactic Acid | 2022 |
Lactate-dependent chaperone-mediated autophagy induces oscillatory HIF-1α activity promoting proliferation of hypoxic cells.
Topics: Cell Line, Tumor; Cell Proliferation; Chaperone-Mediated Autophagy; Humans; Hypoxia; Lactic Acid | 2022 |
Lactate-dependent chaperone-mediated autophagy induces oscillatory HIF-1α activity promoting proliferation of hypoxic cells.
Topics: Cell Line, Tumor; Cell Proliferation; Chaperone-Mediated Autophagy; Humans; Hypoxia; Lactic Acid | 2022 |
Lactate-dependent chaperone-mediated autophagy induces oscillatory HIF-1α activity promoting proliferation of hypoxic cells.
Topics: Cell Line, Tumor; Cell Proliferation; Chaperone-Mediated Autophagy; Humans; Hypoxia; Lactic Acid | 2022 |
O
Topics: Animals; Cell Line, Tumor; Hydrogen Peroxide; Hypoxia; Lactic Acid; Mice; Nanoparticles; Neoplasms; | 2022 |
O
Topics: Animals; Cell Line, Tumor; Hydrogen Peroxide; Hypoxia; Lactic Acid; Mice; Nanoparticles; Neoplasms; | 2022 |
O
Topics: Animals; Cell Line, Tumor; Hydrogen Peroxide; Hypoxia; Lactic Acid; Mice; Nanoparticles; Neoplasms; | 2022 |
O
Topics: Animals; Cell Line, Tumor; Hydrogen Peroxide; Hypoxia; Lactic Acid; Mice; Nanoparticles; Neoplasms; | 2022 |
Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology.
Topics: Antineoplastic Agents; Humans; Hypoxia; Lactic Acid; Monocarboxylic Acid Transporters; Neoplasms; Sy | 2023 |
Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology.
Topics: Antineoplastic Agents; Humans; Hypoxia; Lactic Acid; Monocarboxylic Acid Transporters; Neoplasms; Sy | 2023 |
Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology.
Topics: Antineoplastic Agents; Humans; Hypoxia; Lactic Acid; Monocarboxylic Acid Transporters; Neoplasms; Sy | 2023 |
Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology.
Topics: Antineoplastic Agents; Humans; Hypoxia; Lactic Acid; Monocarboxylic Acid Transporters; Neoplasms; Sy | 2023 |
Acidic and hypoxic tumor microenvironment regulation by CaO
Topics: Cell Line, Tumor; Humans; Hypoxia; Lactic Acid; Nanoparticles; Tumor Microenvironment | 2022 |
Hypoxia Does Not Change Performance and Psychophysiological Responses During Repeated Cycling Sprints to Exhaustion With Short Exercise-to-Rest Ratio.
Topics: Athletic Performance; Exercise; Humans; Hypoxia; Lactic Acid; Oxygen; Oxygen Consumption; Quadriceps | 2023 |
Hypoxia enhances IPF mesenchymal progenitor cell fibrogenicity via the lactate/GPR81/HIF1α pathway.
Topics: Humans; Hypoxia; Idiopathic Pulmonary Fibrosis; Lactic Acid; Mesenchymal Stem Cells; Signal Transduc | 2023 |
Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction.
Topics: Endothelial Cells; Fibrosis; Humans; Hypoxia; Lactic Acid; Myocardial Infarction; Transforming Growt | 2023 |
Monocarboxylate transporter-dependent mechanism is involved in the adaptability of the body to exercise-induced fatigue under high-altitude hypoxia environment.
Topics: Altitude; Altitude Sickness; Animals; Fatigue; Hypoxia; Lactic Acid; Rats | 2023 |
A monocarboxylate transporter-dependent mechanism confers resistance to exercise-induced fatigue in a high-altitude hypoxic environment.
Topics: Altitude; Animals; Brain; Fatigue; Hypoxia; Lactic Acid; Membrane Transport Proteins; Rats | 2023 |
Different reoxygenation rates induce different metabolic, apoptotic and immune responses in Golden Pompano (Trachinotus blochii) after hypoxic stress.
Topics: Animals; Cell Hypoxia; Fishes; Hypoxia; Immunity; Lactic Acid; Oxygen | 2023 |
Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation.
Topics: Glucose; Humans; Hypoxia; Lactic Acid; Oxidative Phosphorylation; Retinal Degeneration; Retinal Rod | 2023 |
[Effects of blocking lactate production by 2-DG on hypoxic injury of HT22 neurons and its mechanisms].
Topics: Apoptosis; Deoxyglucose; Humans; Hypoxia; Lactic Acid; Neurons; Oxidative Stress; Reactive Oxygen Sp | 2022 |
Energy metabolic mechanisms for high altitude sickness: Downregulation of glycolysis and upregulation of the lactic acid/amino acid-pyruvate-TCA pathways and fatty acid oxidation.
Topics: Altitude; Altitude Sickness; Amino Acids; Animals; Citric Acid Cycle; Down-Regulation; Fatty Acids; | 2023 |
Promotion of NAD
Topics: Bone Marrow; Cellular Senescence; Endothelial Progenitor Cells; Humans; Hypoxia; Isoenzymes; L-Lacta | 2023 |
HIF-1α drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1.
Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Excitatory Amino Acid Transporter 3; Ferroptosis; Hypoxia; | 2023 |
Fetal Oxygenation from the 23rd to the 36th Week of Gestation Evaluated through the Umbilical Cord Blood Gas Analysis.
Topics: Female; Fetal Blood; Fetus; Humans; Hypoxia; Infant; Infant, Newborn; Lactic Acid; Oxygen; Pregnancy | 2023 |
S-Adenosylhomocysteine Is a Useful Metabolic Factor in the Early Prediction of Septic Disease Progression and Death in Critically Ill Patients: A Prospective Cohort Study.
Topics: Critical Illness; Disease Progression; Humans; Hypoxia; Lactic Acid; Multiple Organ Failure; Oxygen; | 2023 |
Effect of Diosmin on Selected Parameters of Oxygen Homeostasis.
Topics: Cardiovascular Diseases; Diosmin; Fibroblast Growth Factors; Homeostasis; Humans; Hypoxia; Inflammat | 2023 |
Relative hypoxemia at depth during breath-hold diving investigated through arterial blood gas analysis and lung ultrasound.
Topics: Blood Gas Analysis; Carbon Dioxide; Diving; Edema; Humans; Hypoxia; Lactic Acid; Oxygen; Pulmonary A | 2023 |
Persistent hypoxia promotes myofibroblast differentiation via GPR-81 and differential regulation of LDH isoenzymes in normal and idiopathic pulmonary fibrosis fibroblasts.
Topics: Fibroblasts; Humans; Hypoxia; Idiopathic Pulmonary Fibrosis; Isoenzymes; L-Lactate Dehydrogenase; La | 2023 |
3, 3'-diindolylmethane, a natural aryl hydrocarbon receptor agonist, alleviates ulcerative colitis by enhancing "glycolysis-lactate-STAT3″ and TIP60 signals-mediated Treg differentiation.
Topics: Animals; Cell Differentiation; Colitis; Colitis, Ulcerative; Forkhead Transcription Factors; Glucose | 2023 |
Hypoxia-sensing VGLL4 promotes LDHA-driven lactate production to ameliorate neuronal dysfunction in a cellular model relevant to Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Hypoxia; Lactic A | 2023 |
Microenvironmental stress drives tumor cell maladaptation and malignancy through regulation of mitochondrial and nuclear cytochrome c oxidase subunits.
Topics: Electron Transport Complex IV; Glucose; Humans; Hypoxia; Lactic Acid; Neoplasms; Tumor Microenvironm | 2023 |
IFN-γ lowers tumor growth by increasing glycolysis and lactate production in a nitric oxide-dependent manner: implications for cancer immunotherapy.
Topics: Cell Line, Tumor; Glycolysis; Humans; Hypoxia; Interferon-gamma; Lactic Acid; Neoplasms; Nitric Oxid | 2023 |
Absolute expressions of hypoxia-inducible factor-1 alpha (HIF1A) transcript and the associated genes in chicken skeletal muscle with white striping and wooden breast myopathies.
Topics: Animals; Chickens; Gene Expression Regulation; Glycogen; Hydrogen-Ion Concentration; Hypoxia; Hypoxi | 2019 |
Polycyclic aromatic hydrocarbon and hypoxia exposures result in mitochondrial dysfunction in zebrafish.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Area Under Curve; Embryo, Nonmammalian; Ener | 2019 |
Metabolic regulation of gene expression by histone lactylation.
Topics: Acetylation; Amino Acid Sequence; Animals; Cell Line, Tumor; Chromatin; Epigenesis, Genetic; Glycoly | 2019 |
Cardiac Autonomic and Physiological Responses to Moderate- intensity Exercise in Hypoxia.
Topics: Adult; Autonomic Nervous System; Exercise; Heart; Heart Rate; Humans; Hypoxia; Lactic Acid; Male; Ox | 2019 |
Intermittent Hypoxic Training at Lactate Threshold Intensity Improves Aiming Performance in Well-Trained Biathletes with Little Change of Cardiovascular Variables.
Topics: Adolescent; Athletes; Cardiovascular System; Exercise; Exercise Test; Exercise Tolerance; Humans; Hy | 2019 |
MicroRNA-124 regulates lactate transportation in the muscle of largemouth bass (micropterus salmoides) under hypoxia by targeting MCT1.
Topics: Acclimatization; Animals; Bass; Carbohydrate Metabolism; Gene Expression Regulation; Hypoxia; Lactic | 2020 |
Influence of 96h sub-lethal copper exposure on aerobic scope and recovery from exhaustive exercise in killifish (Fundulus heteroclitus).
Topics: Acclimatization; Anaerobiosis; Animals; Copper; Ecosystem; Fresh Water; Fundulidae; Glycogen; Hypoxi | 2020 |
The hypoxia-lactate axis tempers inflammation.
Topics: Glycolysis; Histone Code; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; | 2020 |
Hypoxic-ischemic enterocolitis: a proposal of a new terminology for early NEC or NEC-like disease in preterm infants, a single-center prospective observational study.
Topics: Biomarkers; Case-Control Studies; Enterocolitis, Necrotizing; Fatty Acid-Binding Proteins; Female; F | 2020 |
A genetic toolkit for the analysis of metabolic changes in Drosophila provides new insights into metabolic responses to stress and malignant transformation.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Drosophila melanogas | 2019 |
Serum Autofluorescence and Biochemical Markers in Athlete's Response to Strength Effort in Normobaric Hypoxia: A Preliminary Study.
Topics: Adult; Altitude; Athletes; Biomarkers; Creatine Kinase; Exercise; Humans; Hypoxia; Lactic Acid; Male | 2019 |
[Effects of the Fomes officinalis Ames. polysaccharides on anti-fatigue and hypoxia tolerance in mice].
Topics: Animals; Blood Urea Nitrogen; Coriolaceae; Fatigue; Glycogen; Hypoxia; Lactic Acid; Liver; Mice; Pla | 2019 |
Autonomic response to fetal acidosis using an experimental sheep model.
Topics: Acidosis; Animals; Autonomic Nervous System; Blood Gas Analysis; Constriction; Female; Fetal Monitor | 2020 |
Nrf2 Activation Enhances Muscular MCT1 Expression and Hypoxic Exercise Capacity.
Topics: Activating Transcription Factor 3; Animals; Basigin; Energy Metabolism; Hypoxia; Hypoxia-Inducible F | 2020 |
Altered Cerebral Blood Flow and Potential Neuroprotective Effect of Human Relaxin-2 (Serelaxin) During Hypoxia or Severe Hypovolemia in a Sheep Model.
Topics: Animals; Arterioles; Brain; Cerebrovascular Circulation; Disease Models, Animal; Hypovolemia; Hypoxi | 2020 |
Neuromuscular Fatigue of Cycling Exercise in Hypoxia.
Topics: Adult; Bicycling; Electromyography; Ergometry; Evoked Potentials, Motor; Fatigue; Humans; Hypoxia; K | 2020 |
Can COVID-19 cause myalgia with a completely different mechanism? A hypothesis.
Topics: Betacoronavirus; Coronavirus Infections; COVID-19; Humans; Hypoxia; L-Lactate Dehydrogenase; Lactic | 2020 |
Computational modeling to determine key regulators of hypoxia effects on the lactate production in the glycolysis pathway.
Topics: Gene Expression; Glycolysis; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lactic Acid | 2020 |
A Metabolomics Study of Hypoxia Ischemia during Mouse Brain Development Using Hyperpolarized 13C.
Topics: Animals; Brain; Carbon Isotopes; Hypoxia; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonanc | 2020 |
Openwork@Dendritic Mesoporous Silica Nanoparticles for Lactate Depletion and Tumor Microenvironment Regulation.
Topics: Angiogenesis Inhibitors; Animals; Anthraquinones; Antineoplastic Agents; Breast Neoplasms; Cell Line | 2020 |
Lactate Administration Reduces Brain Injury and Ameliorates Behavioral Outcomes Following Neonatal Hypoxia-Ischemia.
Topics: Animals; Animals, Newborn; Brain; Brain Injuries; Disease Models, Animal; Female; Hypoxia; Hypoxia-I | 2020 |
Carbohydrate Supplementation and the Influence of Breakfast on Fuel Use in Hypoxia.
Topics: Blood Glucose; Breakfast; Breath Tests; Calorimetry, Indirect; Dietary Carbohydrates; Dietary Supple | 2021 |
No Influence of Acute Moderate Normobaric Hypoxia on Performance and Blood Lactate Concentration Responses to Repeated Wingates.
Topics: Athletic Performance; Exercise Test; Humans; Hypoxia; Lactic Acid; Male; Oxygen Consumption; Physica | 2021 |
Salbutamol-induced lactic acidosis in status asthmaticus survivor.
Topics: Acidosis; Acidosis, Lactic; Acidosis, Respiratory; Adrenergic beta-2 Receptor Agonists; Adult; Albut | 2021 |
Negative central venous to arterial lactate gradient in patients receiving vasopressors is associated with higher ICU 30-day mortality: a retrospective cohort study.
Topics: Aged; Arteries; Beijing; Cohort Studies; Critical Care; Critical Illness; Female; Hospital Mortality | 2021 |
Diagnostic challenge: an atypical presentation of infective endocarditis.
Topics: Bacteremia; Blood Culture; C-Reactive Protein; Diagnosis, Differential; Diarrhea; Dysentery; Early W | 2021 |
Severely High Lactic Acid in Severe Pneumonia Patient: a Case Report.
Topics: Humans; Hypoxia; Lactic Acid; Pneumonia | 2021 |
Hypoxia tolerance and metabolic coping strategies in Oreochromis niloticus.
Topics: Acidosis; Adaptation, Psychological; Anaerobiosis; Animals; Aquaculture; Blood Glucose; Cichlids; Gi | 2021 |
No Influence of Nonivamide-nicoboxil on the Peak Power Output in Competitive Sportsmen.
Topics: Administration, Cutaneous; Adult; Athletic Performance; Capsaicin; Cross-Over Studies; Exercise Test | 2021 |
Extreme hypoxia and high lactate concentrations in early chicken embryos show that cutaneous oxygen uptake is limited by diffusion and metabolism is partially anaerobic.
Topics: Anaerobiosis; Animals; Chick Embryo; Chickens; Hypoxia; Lactic Acid; Oxygen | 2021 |
In Vitro Evaluation of CD276-CAR NK-92 Functionality, Migration and Invasion Potential in the Presence of Immune Inhibitory Factors of the Tumor Microenvironment.
Topics: Antigens, Neoplasm; B7 Antigens; Cell Line, Tumor; Cell Movement; CRISPR-Cas Systems; Cytotoxicity, | 2021 |
Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males.
Topics: Adolescent; Adult; Biomarkers; Down-Regulation; Endotoxemia; Healthy Volunteers; Humans; Hypoxia; In | 2021 |
Lactate sensing mechanisms in arterial chemoreceptor cells.
Topics: Animals; Arteries; Carotid Body; Chemoreceptor Cells; Homeostasis; Hydrogen-Ion Concentration; Hypox | 2021 |
Protective effect of 5,6,7,8-trtrahydroxyflavone against acute hypobaric hypoxia induced-oxidative stress in mice.
Topics: Animals; Blood Pressure; Brain; Flavones; Heart; Heart Rate; Hydrogen Peroxide; Hypoxia; L-Lactate D | 2021 |
Hypoxia‑induced lactate dehydrogenase A protects cells from apoptosis in endometriosis.
Topics: Adult; Apoptosis; Cell Proliferation; Endometriosis; Endometrium; Epithelial Cells; Epithelial-Mesen | 2021 |
Effects of Acute Hypoxia on Lactate Thresholds and High-Intensity Endurance Performance-A Pilot Study.
Topics: Altitude; Exercise; Exercise Test; Humans; Hypoxia; Lactic Acid; Oxygen Consumption; Physical Endura | 2021 |
Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Gastrointestinal Microbiome; Hypoxia; Lactic | 2021 |
Human Cerebral Perfusion, Oxygen Consumption, and Lactate Production in Response to Hypoxic Exposure.
Topics: Brain; Cerebrovascular Circulation; Humans; Hypoxia; Lactic Acid; Oxygen; Oxygen Consumption | 2022 |
Impact of Endurance Exercise in Hypoxia on Muscle Damage, Inflammatory and Performance Responses.
Topics: Adult; Athletes; Biomarkers; Energy Metabolism; Exercise Test; High-Intensity Interval Training; Hum | 2018 |
The physiological and molecular response of Aurelia sp.1 under hypoxia.
Topics: Animals; Gene Expression Regulation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; L-Lactate D | 2017 |
Overexpression of pyruvate dehydrogenase kinase 1 in retinoblastoma: A potential therapeutic opportunity for targeting vitreous seeds and hypoxic regions.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dichloroaceti | 2017 |
Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors.
Topics: Adenosine Triphosphate; Animals; Biomarkers; Cell Line, Tumor; Disease Models, Animal; Energy Metabo | 2017 |
The high tolerance to aluminium in crucian carp (Carassius carassius) is associated with its ability to avoid hypoxia.
Topics: Adaptation, Physiological; Aluminum; Animals; Carps; Cetylpyridinium; Electric Conductivity; Ethanol | 2017 |
Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression.
Topics: Acriflavine; Animals; Basigin; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Disease | 2017 |
Acute physiological and perceptual responses to high-load resistance exercise in hypoxia.
Topics: Adult; Biomarkers; Energy Metabolism; Humans; Hypoxia; Lactic Acid; Male; Muscle Contraction; Muscle | 2018 |
Two common variants of human papillomavirus type 16 E6 differentially deregulate sugar metabolism and hypoxia signalling in permissive human keratinocytes.
Topics: Glucose; Host-Pathogen Interactions; Human papillomavirus 16; Humans; Hypoxia; Hypoxia-Inducible Fac | 2017 |
Attenuation of
Topics: 3' Untranslated Regions; Animals; Apoptosis; Base Sequence; Cell Hypoxia; Cell Line; Cell Survival; | 2017 |
The Collocation of Ischemia-Modified Albumin and Blood Gas Parameters in the PICU Setting.
Topics: Biomarkers; Blood Gas Analysis; Carbon Dioxide; Child; Female; Humans; Hypoxia; Intensive Care Units | 2018 |
N-acetylcysteine effects on a murine model of chronic critical limb ischemia.
Topics: Acetylcysteine; Animals; Disease Models, Animal; Hindlimb; Hypoxia; Hypoxia-Inducible Factor 1, alph | 2018 |
Cerebral metabolism and vascular reactivity during breath-hold and hypoxic challenge in freedivers and healthy controls.
Topics: Adult; Brain; Breath Holding; Cerebrovascular Circulation; Diving; Female; Glycolysis; Humans; Hypox | 2019 |
The comparison of umbilical cord arterial blood lactate and pH values for predicting short-term neonatal outcomes.
Topics: Apgar Score; Female; Fetal Blood; Humans; Hydrogen-Ion Concentration; Hypoxia; Infant, Newborn; Infa | 2017 |
Cerebral blood flow, oxygen metabolism, and lactate during hypoxia in patients with obstructive sleep apnea.
Topics: Adult; Biomarkers; Cerebrovascular Circulation; Continuous Positive Airway Pressure; Female; Humans; | 2018 |
Comparison of changes in mitochondrial bioenergetics between keratinocytes in human external auditory canal skin and cholesteatomas from normoxia to hypoxia.
Topics: Adenosine Triphosphate; Autophagy; Cell Proliferation; Cell Respiration; Cell Survival; Cells, Cultu | 2018 |
Eryptosis and hemorheological responses to maximal exercise in athletes: Comparison between running and cycling.
Topics: Adult; Bicycling; Blood Glucose; Blood Viscosity; Calcium; Eryptosis; Erythrocyte Deformability; Fem | 2018 |
Metabolic reprogramming of Kaposi's sarcoma associated herpes virus infected B-cells in hypoxia.
Topics: B-Lymphocytes; Blotting, Western; Gene Expression Regulation, Viral; Glucose; Herpesvirus 8, Human; | 2018 |
High-performance reoxygenation from PLGA-PEG/PFOB emulsions: a feedback relationship between ROS and HIF-1α.
Topics: A549 Cells; Acute Lung Injury; Animals; Cell Hypoxia; Cell Survival; Drug Delivery Systems; Emulsion | 2018 |
Neurological impairments in hypoxic neonates and lactate levels.
Topics: Acidosis; Age Factors; Blood Gas Analysis; Female; Gestational Age; Humans; Hypoxia; Infant, Newborn | 2018 |
Effect of environmental feedbacks on pacing strategy and affective load during a self-paced 30 min cycling time trial.
Topics: Adult; Affect; Altitude; Athletes; Athletic Performance; Bicycling; Feedback, Psychological; Heart R | 2019 |
Effects of tumor necrosis factor-α-induced exosomes on the endothelial cellular behavior, metabolism and bioenergetics.
Topics: Apoptosis; Cell Movement; Cells, Cultured; Energy Metabolism; Exosomes; Glycolysis; Human Umbilical | 2019 |
The Post-Exercise Inflammatory Response to Repeated-Sprint Running in Hypoxia.
Topics: Adult; Altitude; Athletes; Humans; Hypoxia; Inflammation; Interleukins; Lactic Acid; Running; Young | 2018 |
Distinct metabolic adjustments arise from acclimation to constant hypoxia and intermittent hypoxia in estuarine killifish (
Topics: Acclimatization; Anaerobiosis; Animals; Fundulidae; Glucose; Glycogen; Hydrogen-Ion Concentration; H | 2018 |
Development of Inflammatory Hypoxia and Prevalence of Glycolytic Metabolism in Progressing Herpes Stromal Keratitis Lesions.
Topics: Acriflavine; Active Transport, Cell Nucleus; Animals; Anti-Infective Agents, Local; Basic Helix-Loop | 2019 |
Potential metabolic markers in glaucoma and their regulation in response to hypoxia.
Topics: Aged; Amino Acids; Biomarkers; Blood Glucose; Chromatography, High Pressure Liquid; Female; Glaucoma | 2019 |
50 Years Ago in The Journal of Pediatrics: Acid-Base Monitoring of the Fetus during Labor with Blood Obtained from the Scalp.
Topics: Acid-Base Equilibrium; Acidosis; Blood Specimen Collection; Female; Fetal Diseases; Fetal Monitoring | 2019 |
Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain Neoplasms; Echo-Planar Imaging; Female; Glioma; Gl | 2019 |
High Intrarenal Lactate Production Inhibits the Renal Pseudohypoxic Response to Acutely Induced Hypoxia in Diabetes.
Topics: Acute Disease; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Hypoxia; Ki | 2019 |
Coping with exposure to hypoxia: modifications in stress parameters in gilthead seabream (Sparus aurata) fed spirulina (Arthrospira platensis) and brewer's yeast (Saccharomyces cerevisiae).
Topics: Animals; Aquaculture; Blood Glucose; Diet; Hydrocortisone; Hypoxia; Immunoglobulin M; Lactic Acid; R | 2019 |
Physiological adaptations to repeated sprint training in hypoxia induced by voluntary hypoventilation at low lung volume.
Topics: Adaptation, Physiological; Adult; Athletic Performance; Hemoglobins; Humans; Hypoventilation; Hypoxi | 2019 |
Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma.
Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Disease Models | 2013 |
The antioxidative effect of a novel free radical scavenger 4'-hydroxyl-2-substituted phenylnitronyl nitroxide in acute high-altitude hypoxia mice.
Topics: Altitude; Altitude Sickness; Animals; Antioxidants; Catalase; Cyclic N-Oxides; Glutathione Peroxidas | 2013 |
Effects of fatty acid provision during severe hypoxia on routine and maximal performance of the in situ tilapia heart.
Topics: Animals; Cardiac Output; Fatty Acids, Nonesterified; Female; Heart; Heart Rate; Hypoxia; In Vitro Te | 2013 |
Bile benzo[a]pyrene concentration and hepatic CYP1A induction in hypoxic adult tilapia (Oreochromis niloticus).
Topics: Animals; Benzo(a)pyrene; Bile; Blood Glucose; Cytochrome P-450 CYP1A1; Hematocrit; Hypoxia; L-Lactat | 2013 |
The effects of exercise under hypoxia on cognitive function.
Topics: Adult; Body Temperature; Brain; Cognition; Exercise; Heart Rate; Hemoglobins; Humans; Hypoxia; Lacti | 2013 |
Early detection of gut ischemia-reperfusion injury during aortic abdominal aneurysmectomy: a pilot, observational study.
Topics: Aged; Aneurysm, Ruptured; Aortic Aneurysm, Abdominal; Carbon Dioxide; Colon; Constriction; Female; H | 2013 |
Differences of glycolysis in skeletal muscle and lactate metabolism in liver between plateau zokor (Myospalax baileyi) and plateau pika (Ochotona curzoniae).
Topics: Animals; Glycolysis; Hypoxia; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Lactic A | 2013 |
Acute physiological and performance responses to repeated sprints in varying degrees of hypoxia.
Topics: Adult; Athletic Performance; Electromyography; Fatigue; Heart Rate; Humans; Hypoxia; Lactic Acid; Ma | 2014 |
Low-dose vasopressin improves cardiac function in newborn piglets with acute hypoxia-reoxygenation.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Cardiac Output; Dobutamine; Glutathione; Heart Ventr | 2013 |
Acidic lactate sequentially induced lymphogenesis, phlebogenesis, and arteriogenesis (ALPHA) hypothesis: Lactate-triggered glycolytic vasculogenesis that occurs in normoxia or hypoxia and complements the traditional concept of hypoxia-based vasculogenesis
Topics: Fibroblast Growth Factor 2; Glycolysis; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; | 2013 |
Association between a geriatric trauma resuscitation protocol using venous lactate measurements and early trauma surgeon involvement and mortality risk.
Topics: Aged, 80 and over; Colorado; Cooperative Behavior; Early Medical Intervention; Female; Geriatric Ass | 2013 |
Nodal regulates energy metabolism in glioma cells by inducing expression of hypoxia-inducible factor 1α.
Topics: Adenosine Triphosphate; Blotting, Western; Brain Neoplasms; Energy Metabolism; Glioma; Glucose; Glyc | 2013 |
Acid-base patterns in acute severe asthma.
Topics: Acidosis, Respiratory; Acute Disease; Adult; Aged; Aged, 80 and over; Alkalosis, Respiratory; Asthma | 2013 |
Effects of post-resuscitation administration with sodium hydrosulfide on cardiac recovery in hypoxia-reoxygenated newborn piglets.
Topics: Animals; Animals, Newborn; Asphyxia; Biological Transport; Blood Gas Analysis; Female; Glutathione; | 2013 |
Stability of cerebral metabolism and substrate availability in humans during hypoxia and hyperoxia.
Topics: Adult; Analysis of Variance; Blood Flow Velocity; Blood Glucose; Brain; Carbohydrate Metabolism; Car | 2014 |
Tissue-type plasminogen activator mediates neuroglial coupling in the central nervous system.
Topics: AMP-Activated Protein Kinases; Animals; Animals, Newborn; Arabinose; Cell Death; Cells, Cultured; Ce | 2014 |
JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism.
Topics: Active Transport, Cell Nucleus; Allosteric Site; Breast Neoplasms; Carrier Proteins; Cell Line, Tumo | 2014 |
High altitude may alter oxygen availability and renal metabolism in diabetics as measured by hyperpolarized [1-(13)C]pyruvate magnetic resonance imaging.
Topics: Alanine; Altitude; Altitude Sickness; Animals; Atmospheric Pressure; Bicarbonates; Blood Glucose; Di | 2014 |
The gene expression profile of inflammatory, hypoxic and metabolic genes predicts the metastatic spread of human head and neck squamous cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Carcinoma, Squamous Cell; Extracellular Matrix; Femal | 2014 |
Effects of exercise training on indicators of adipose tissue angiogenesis and hypoxia in obese rats.
Topics: Adipose Tissue; Animals; Biomarkers; Hypoxia; Lactic Acid; Male; Neovascularization, Pathologic; Obe | 2014 |
Resting arterial oxygen saturation and breathing frequency as predictors for acute mountain sickness development: a prospective cohort study.
Topics: Acute Disease; Adult; Altitude Sickness; Atmosphere Exposure Chambers; Cohort Studies; Disease Susce | 2014 |
M(o)TOR of pseudo-hypoxic state in aging: rapamycin to the rescue.
Topics: Aging; Animals; Antibiotics, Antineoplastic; Cell Hypoxia; Cell Line; Cell Proliferation; Cellular S | 2014 |
Rapid uptake of glucose and lactate, and not hypoxia, induces apoptosis in three-dimensional tumor tissue culture.
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Gas Chromatography-Mass Spectrometry; | 2014 |
Acute regulation of hematocrit and acid-base balance in chicken embryos in response to severe intrinsic hypercapnic hypoxia.
Topics: Acid-Base Equilibrium; Acid-Base Imbalance; Animals; Chick Embryo; Erythrocyte Indices; Erythrocytes | 2014 |
Prolonged hypoxia increases survival even in Zebrafish (Danio rerio) showing cardiac arrhythmia.
Topics: Animals; Arrhythmias, Cardiac; Blotting, Western; Energy Metabolism; Hypoxia; Lactic Acid; Larva; Mi | 2014 |
Riboflavin supplementation improves energy metabolism in mice exposed to acute hypoxia.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Carnitine; Dietary Supplements; Drug Evaluation, Prec | 2014 |
Greater performance impairment of black runners than white runners when running in hypoxia.
Topics: Adult; Anthropometry; Black People; Exercise Test; Fatigue; Heart Rate; Humans; Hypoxia; Lactic Acid | 2014 |
Effect of temperature on hypoxia tolerance and its underlying biochemical mechanism in two juvenile cyprinids exhibiting distinct hypoxia sensitivities.
Topics: Adaptation, Physiological; Animals; Brain; Cyprinidae; Glucose; Glycogen; Hypoxia; Lactic Acid; Live | 2015 |
Dichloroacetate selectively improves cardiac function and metabolism in female and male rainbow trout.
Topics: Animals; Calcium; Cardiac Pacing, Artificial; Citric Acid; Dichloroacetic Acid; Energy Metabolism; E | 2014 |
The combined effect of hypoxia and nutritional status on metabolic and ionoregulatory responses of common carp (Cyprinus carpio).
Topics: Ammonia; Animals; Carps; Energy Metabolism; Fasting; Feeding Behavior; Gills; Glycogen; Hypoxia; Ion | 2015 |
Interstitial lactate, lactate/pyruvate and glucose in rat muscle before, during and in the recovery from global hypoxia.
Topics: Animals; Energy Metabolism; Glucose; Hypoxia; Lactic Acid; Male; Microdialysis; Muscle, Skeletal; Py | 2014 |
Exercise effects on erythrocyte deformability in exercise-induced arterial hypoxemia.
Topics: Adult; Erythrocyte Deformability; Erythrocyte Indices; Erythrocytes; Exercise; Hemoglobinometry; Hum | 2015 |
Anoxia-induced changes in optimal substrate for peripheral nerve.
Topics: 3-Hydroxybutyric Acid; Acetates; Action Potentials; Animals; Fructose; Galactose; Glucose; Hypoxia; | 2015 |
Does moderate hypoxia alter working memory and executive function during prolonged exercise?
Topics: Bicycling; Executive Function; Exercise; Heart Rate; Humans; Hypoxia; Lactic Acid; Male; Memory, Sho | 2015 |
Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells.
Topics: Blotting, Western; Cell Proliferation; Colorectal Neoplasms; Dichloroacetic Acid; Flow Cytometry; Gl | 2015 |
Hypoxia enhances antitumor activity of dichloroacetate.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell | 2014 |
Elite female athletes' ventilatory compensation to decreased inspired O2 during the wingate test.
Topics: Adenosine Triphosphate; Adolescent; Energy Metabolism; Fatigue; Female; Humans; Hypoxia; Lactic Acid | 2015 |
The characteristics and correlation between the ischemia-reperfusion and changes of redox status in the early stage of severe burns.
Topics: Adult; Burns; Case-Control Studies; Cohort Studies; Disease Progression; Hematocrit; Humans; Hypoxia | 2015 |
Day-to-day variability in cardiorespiratory responses to hypoxic cycle exercise.
Topics: Adult; Analysis of Variance; Bicycling; Carbon Dioxide; Exercise; Heart Rate; Humans; Hypoxia; Lacti | 2015 |
Platinum-doped ceria based biosensor for in vitro and in vivo monitoring of lactate during hypoxia.
Topics: Animals; Biosensing Techniques; Brain; Cerium; Electrochemistry; Enzymes, Immobilized; Hippocampus; | 2015 |
Decrease in circulating plasmacytoid dendritic cells during short-term systemic normobaric hypoxia.
Topics: Adult; Altitude; Atmospheric Pressure; Cell Count; Dendritic Cells; Female; Flow Cytometry; Healthy | 2016 |
PLGA/poloxamer nanoparticles loaded with EPAS1 siRNA for the treatment of pancreatic cancer in vitro and in vivo.
Topics: Animals; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cell Proliferati | 2015 |
Cerebral water and ion balance remains stable when humans are exposed to acute hypoxic exercise.
Topics: Acid-Base Equilibrium; Adult; Altitude Sickness; Body Water; Brain; Brain Chemistry; Brain Edema; Ex | 2015 |
Measurement of the acute metabolic response to hypoxia in rat tumours in vivo using magnetic resonance spectroscopy and hyperpolarised pyruvate.
Topics: Animals; Carbon Isotopes; Disease Models, Animal; Fibrosarcoma; Hypoxia; Lactic Acid; Magnetic Reson | 2015 |
Hypoxia decreases glucagon-like peptide-1 secretion from the GLUTag cell line.
Topics: Adenosine Triphosphate; Animals; Cell Line; Colforsin; Colon; Cyclic AMP Response Element-Binding Pr | 2015 |
64Cu-CTS: A Promising Radiopharmaceutical for the Identification of Low-Grade Cardiac Hypoxia by PET.
Topics: Adenosine Triphosphate; Animals; Coordination Complexes; Copper Radioisotopes; Creatine Kinase; Hear | 2015 |
A lactate-induced response to hypoxia.
Topics: Cell Hypoxia; Cell Line; Gene Expression Regulation; Humans; Hypoxia; Hypoxia-Inducible Factor-Proli | 2015 |
NDRG3-mediated lactate signaling in hypoxia.
Topics: Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxyge | 2015 |
[The expression of the sperm-specific lactate dehydrogenase gene Ldh-c in plateau pika (Ochotona curzoniae) cardiac muscle and its effect on the anaerobic glycolysis].
Topics: Acclimatization; Animals; Glycolysis; Hypoxia; Isoenzymes; L-Lactate Dehydrogenase; Lactic Acid; Lag | 2015 |
Chronic stress of rainbow trout Oncorhynchus mykiss at high altitude: a field study.
Topics: Altitude; Animals; Antioxidants; Blood Glucose; Hemoglobins; Hydrocortisone; Hypoxia; Lactic Acid; M | 2015 |
Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice.
Topics: Acclimatization; Altitude; Animals; Atrial Natriuretic Factor; Cardiac Output; Ethiopia; Female; Hea | 2015 |
What limits performance during whole-body incremental exercise to exhaustion in humans?
Topics: Adenosine Triphosphate; Adult; Exercise; Exercise Test; Fatigue; Humans; Hydrogen-Ion Concentration; | 2015 |
Anti-hypoxia Activity of the Novel NO Donor Acetyl Ferulic Isosorbide Mononitrate in Acute High-Altitude Hypoxia Mice.
Topics: Adenosine Triphosphate; Altitude Sickness; Animals; Blood Pressure; Catalase; Cerebrum; Glutathione | 2015 |
Elevated serum uric acid after injury correlates with the early acute kidney in severe burns.
Topics: Acute Kidney Injury; Adult; APACHE; Body Surface Area; Burns; C-Reactive Protein; Cohort Studies; Cr | 2015 |
Oxygen regulation of breathing through an olfactory receptor activated by lactate.
Topics: Animals; Calcium Signaling; Carotid Body; Carotid Sinus; Female; HEK293 Cells; Humans; Hypercapnia; | 2015 |
Phenotypic plasticity in the common snapping turtle (Chelydra serpentina): long-term physiological effects of chronic hypoxia during embryonic development.
Topics: Adaptation, Physiological; Age Factors; Animals; Arterial Pressure; Biomarkers; Blood Glucose; Body | 2016 |
REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia.
Topics: Base Sequence; Binding Sites; Computational Biology; Gene Expression Regulation; Glucose; Glycolysis | 2015 |
Acute hypoxia increases the cerebral metabolic rate - a magnetic resonance imaging study.
Topics: Adolescent; Adult; Brain; Cerebrovascular Circulation; Creatine; Energy Metabolism; Glutamic Acid; H | 2016 |
XBP1 silencing decreases glioma cell viability and glycolysis possibly by inhibiting HK2 expression.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Cell Proliferation; DNA-Binding Proteins; Female; Gene S | 2016 |
Nitric oxide availability in deeply hypoxic crucian carp: acute and chronic changes and utilization of ambient nitrite reservoirs.
Topics: Adenosine Triphosphate; Animals; Carps; Female; Gills; Hypoxia; Lactic Acid; Male; Nitric Oxide; Nit | 2016 |
Dysregulated bioenergetics: a key regulator of joint inflammation.
Topics: Amino Acids, Dicarboxylic; Arthritis, Rheumatoid; Cell Movement; Cells, Cultured; Cytokines; DNA, Mi | 2016 |
A comparison of constant acceleration swimming speeds when acceleration rates are different with critical swimming speeds in Chinese bream under two oxygen tensions.
Topics: Acceleration; Animals; Cyprinidae; Glucose; Glycogen; Hypoxia; Lactic Acid; Liver; Muscles; Oxygen; | 2016 |
Glycogen dynamics of crucian carp (Carassius carassius) in prolonged anoxia.
Topics: Acclimatization; Acetates; Ammonia; Animals; Body Weight; Brain; Carps; Ethanol; Gills; Glycogen; He | 2016 |
Severe hypoxemia induced by prolonged expiration and reduced frequency breathing during submaximal swimming.
Topics: Bicarbonates; Breath Holding; Carbon Dioxide; Heart Rate; Humans; Hydrogen-Ion Concentration; Hypoxi | 2017 |
Effect of Hypoxia on Ldh-c Expression in Somatic Cells of Plateau Pika.
Topics: Acclimatization; Adaptation, Physiological; Altitude; Animals; Blotting, Western; Brain; Glycolysis; | 2016 |
Selective accumulation of biotin in arterial chemoreceptors: requirement for carotid body exocytotic dopamine secretion.
Topics: Adenosine Triphosphate; Adrenal Medulla; Animals; Arteries; Biotin; Carotid Body; Chromaffin Cells; | 2016 |
Hypoxia-responsive miR-210 promotes self-renewal capacity of colon tumor-initiating cells by repressing ISCU and by inducing lactate production.
Topics: Aged; Aged, 80 and over; Carcinogenesis; Cell Self Renewal; Colon; Colonic Neoplasms; Colorectal Neo | 2016 |
Evaluation of the protective effect of thiamine pyrophosphate based on the biochemical analysis of rabbit foetuses at 30 days of gestation.
Topics: Animals; Blood Glucose; Calcium; Female; Fetus; Hydrogen-Ion Concentration; Hypoxia; Ischemia; Lacti | 2016 |
Acute Physiological Responses to Moderate-Load Resistance Exercise in Hypoxia.
Topics: Adult; Electromyography; Heart Rate; Humans; Hypoxia; Lactic Acid; Male; Oxygen; Resistance Training | 2017 |
Hypoxia induces glucose uptake and metabolism of adipose‑derived stem cells.
Topics: Adipose Tissue; Female; Gene Expression Regulation, Enzymologic; Glucose; Glucose Transport Proteins | 2016 |
Neurochemical changes following combined hypoxemia and hemorrhagic shock in a rat model of penetrating ballistic-like brain injury: A microdialysis study.
Topics: Animals; Brain; Disease Models, Animal; Glucose; Head Injuries, Penetrating; Hypoxia; Lactic Acid; M | 2016 |
cGMP-Phosphodiesterase Inhibition Prevents Hypoxia-Induced Cell Death Activation in Porcine Retinal Explants.
Topics: Animals; Antioxidants; Caspase 3; Cell Death; Cyclic GMP; Gene Expression Regulation; Hypoxia; Hypox | 2016 |
Reasons for death in patients with sepsis and septic shock.
Topics: Aged; Aged, 80 and over; Cause of Death; Cohort Studies; Consensus; Death, Sudden, Cardiac; Female; | 2017 |
Sirtuin 6 attenuates periapical lesion propagation by modulating hypoxia-induced chemokine (C-C motif) ligand 2 production in osteoblasts.
Topics: Animals; Blotting, Western; Cells, Cultured; Chemokine CCL2; Hypoxia; Lactic Acid; Mice; Mitochondri | 2018 |
pH, Lactate, and Hypoxia: Reciprocity in Regulating High-Affinity Monocarboxylate Transporter Expression in Glioblastoma.
Topics: Astrocytes; Cell Hypoxia; Cell Line, Tumor; Cells, Cultured; Gene Expression; Gene Expression Regula | 2017 |
Prognostic value of plasma lactate levels in a retrospective cohort presenting at a university hospital emergency department.
Topics: Aged; Aged, 80 and over; Comorbidity; Diabetes Mellitus; Emergency Service, Hospital; Female; Hospit | 2017 |
Metabolic origins of spatial organization in the tumor microenvironment.
Topics: Cell Line, Tumor; Cluster Analysis; Energy Metabolism; Extracellular Space; Gene Expression Profilin | 2017 |
[Acute hypoxic hypoxia increases lactate concentration in amniotic fluid of rabbits on 27-28th day of pregnancy].
Topics: Amniotic Fluid; Animals; Creatinine; Female; Fetus; Hypoxia; Lactic Acid; Oxygen; Placenta; Pregnanc | 2017 |
White sturgeon (Acipenser transmontanus) acid-base regulation differs in response to different types of acidoses.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Acidosis, Respiratory; Animals; Brain; Carbon Dioxide; Chlo | 2017 |
Morphofunctional responses to anaemia in rat skeletal muscle.
Topics: Adenosine Triphosphate; Anemia; Animals; Capillaries; Creatine; Histocytochemistry; Hypoxia; Lactic | 2008 |
PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer.
Topics: Base Sequence; Carcinoma, Squamous Cell; Cell Line, Tumor; DNA Primers; Gene Silencing; Head and Nec | 2008 |
Respiratory responses to progressive hypoxia in the Amazonian oscar, Astronotus ocellatus.
Topics: Adaptation, Physiological; Anaerobic Threshold; Animals; Cell Respiration; Cichlids; Energy Metaboli | 2008 |
[Levels of lactic acid].
Topics: Acidosis, Lactic; Arteries; Blood Specimen Collection; Causality; Drug Interactions; Humans; Hypoxia | 2008 |
Effects of hypoxia on relationships between cytosolic and mitochondrial NAD(P)H redox and superoxide generation in coronary arterial smooth muscle.
Topics: Animals; Cattle; Coronary Vessels; Cytosol; Fluorescent Dyes; Hypoxia; In Vitro Techniques; Lactic A | 2008 |
Effects of continuous hypoxia on energy metabolism in cultured cerebro-cortical neurons.
Topics: Animals; Carbon Isotopes; Cells, Cultured; Cerebellum; Cerebral Cortex; Citrate (si)-Synthase; Embry | 2008 |
Effects of acute intermittent hypercapnic hypoxia on insulin sensitivity in piglets using euglycemic clamp.
Topics: Animals; Animals, Newborn; Blood Gas Analysis; Blood Glucose; Blood Pressure; Glucose Clamp Techniqu | 2008 |
Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction.
Topics: Acidosis; Amino Acids; Animals; Blood Glucose; Carbon Dioxide; Disease Models, Animal; Down-Regulati | 2009 |
Thermoregulatory and metabolic responses of Japanese quail to hypoxia.
Topics: Acclimatization; Animals; Body Temperature Regulation; Chronic Disease; Coturnix; Hypercapnia; Hypox | 2008 |
Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis.
Topics: Adult; Aged; Aged, 80 and over; Animals; Arthritis; Arthritis, Experimental; Blotting, Western; Cell | 2008 |
Pathophysiology of critical ill patients: focus on critical oxygen delivery.
Topics: Acute Disease; Adenosine Triphosphate; Cardiac Output; Cell Hypoxia; Critical Illness; Humans; Hypox | 2008 |
Differential recovery from exercise and hypoxia exposure measured using 31P- and 1H-NMR in white muscle of the common carp Cyprinus carpio.
Topics: Acclimatization; Adenosine Triphosphate; Animals; Carps; Hydrogen; Hypoxia; Lactic Acid; Magnetic Re | 2008 |
About the lactic acid exchange between arterial blood and brain tissue and its changes in lack of oxygen.
Topics: Blood; Brain; Humans; Hypoxia; Lactic Acid; Oxygen; Tissues | 1948 |
On the blood lactic acid response to measured exercise in hypoxic human subjects.
Topics: Blood; Exercise; Humans; Hypoxia; Lactic Acid; Oxygen | 1948 |
Blood lactate and oxygen debt after exhaustive work at different oxygen tensions.
Topics: Blood; Blood Gas Analysis; Humans; Hypoxia; Lactic Acid; Oxygen; Oxygen Consumption; Work | 1948 |
The genomic analysis of lactic acidosis and acidosis response in human cancers.
Topics: Acidosis; Breast Neoplasms; Cells, Cultured; Energy Metabolism; Female; Gene Expression Profiling; G | 2008 |
Arterial blood gases and oxygen content in climbers on Mount Everest.
Topics: Adult; Altitude; Arteries; Atmospheric Pressure; Blood Gas Analysis; Carbon Dioxide; Female; Hemoglo | 2009 |
[The role of hypoxic syndrome in pathogenesis of experimental stress-lesions].
Topics: Animals; Biomarkers; Disease Models, Animal; Hypoxia; Lactic Acid; Male; Oxygen; Pain; Pain Manageme | 2008 |
Commentaries on viewpoint: evidence that reduced skeletal muscle recruitment explains the lactate paradox during exercise at high altitude.
Topics: Acclimatization; Altitude; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lactic Acid; Models, Ne | 2009 |
Last word on viewpoint: evidence that reduced skeletal muscle recruitment explains the lactate paradox during exercise at high altitude.
Topics: Acclimatization; Altitude; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lactic Acid; Models, Ne | 2009 |
Influence of performance level on exercise-induced arterial hypoxemia during prolonged and successive exercise in triathletes.
Topics: Adult; Bicycling; Blood Gas Analysis; Humans; Hypoxia; Lactic Acid; Male; Oximetry; Oxygen Consumpti | 2008 |
Reduced skeletal muscle recruitment does not explain the lactate paradox - part I.
Topics: Acclimatization; Altitude; Brain; Cardiac Output; Exercise; Heart Rate; Humans; Hypoxia; Lactic Acid | 2009 |
Origin of the lactate paradox: muscles or brain?
Topics: Acclimatization; Altitude; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lactic Acid; Models, Ne | 2009 |
Reduced skeletal muscle recruitment does not explain the lactate paradox.
Topics: Acclimatization; Altitude; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lactic Acid; Models, Ne | 2009 |
Commentaries on viewpoint: evidence that reduced skeletal muscle recruitment explains the lactate paradox during exercise at high altitude.
Topics: Acclimatization; Altitude; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lactic Acid; Models, Ne | 2009 |
Blood lactate at high altitude: central command but also mass effect and andrenergic drive.
Topics: Acclimatization; Adrenergic Fibers; Altitude; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lact | 2009 |
Reduced skeletal muscle recruitment does not explain the lactate paradox- part II.
Topics: Acclimatization; Altitude; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lactic Acid; Models, Ne | 2009 |
Commentaries on viewpoint: evidence that reduced skeletal muscle recruitment explains the lactate paradox during exercise at high altitude.
Topics: Acclimatization; Altitude; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lactic Acid; Models, Ne | 2009 |
Origin of the lactate paradox:muscles or brain? Part II.
Topics: Acclimatization; Altitude; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lactic Acid; Models, Ne | 2009 |
Cerebral control of skeletal muscle recruitment during exercise at altitude.
Topics: Acclimatization; Altitude; Brain; Cardiac Output; Cerebrovascular Circulation; Exercise; Humans; Hyp | 2009 |
It takes a brain.
Topics: Acclimatization; Altitude; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lactic Acid; Models, Ne | 2009 |
Commentaries on viewpoint: evidence that reduced skeletal muscle recruitment explains the lactate paradox during exercise at high altitude.
Topics: Acclimatization; Altitude; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lactic Acid; Models, Ne | 2009 |
Mechanism of action of Rhodiola imbricata Edgew during exposure to cold, hypoxia and restraint (C-H-R) stress induced hypothermia and post stress recovery in rats.
Topics: Animals; Blood Glucose; Cold Temperature; Energy Metabolism; Fatty Acids, Nonesterified; Glycogen; G | 2009 |
Exercise- and hypoxia-induced anaerobic metabolism and recovery: a student laboratory exercise using teleost fish.
Topics: Anaerobic Threshold; Animals; Fundulidae; Humans; Hypoxia; Lactic Acid; Models, Animal; Models, Biol | 2009 |
Nitric oxide increases myocardial efficiency in the hypoxia-tolerant turtle Trachemys scripta.
Topics: Adaptation, Biological; Animals; Arginine; Heart Ventricles; Hypoxia; Lactic Acid; Microscopy, Confo | 2009 |
Enhanced leukocyte HIF-1alpha and HIF-1 DNA binding in humans after rapid ascent to 4300 m.
Topics: Adult; Altitude; Biomarkers; Dinoprost; DNA; Female; Free Radicals; Glutathione; Heart Rate; Humans; | 2009 |
Hematological responses of the grey carpet shark (Chiloscyllium punctatum) and the epaulette shark (Hemiscyllium ocellatum) to anoxia and re-oxygenation.
Topics: Adaptation, Physiological; Animals; Blood Glucose; Disease Models, Animal; Erythrocyte Count; Hemato | 2009 |
Failure of hypoxia to exaggerate the metabolic stress in working muscle following short-term training.
Topics: Adaptation, Physiological; Adenine Nucleotides; Bicycling; Exercise; Glucose; Glycolysis; Heart Rate | 2009 |
Muscle bioenergetics and metabolic control at altitude.
Topics: Adaptation, Physiological; Altitude; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lac | 2009 |
Nocturnal hypoxia and arterial lactate levels in sleep-related breathing disorders.
Topics: Adult; Arteries; Biomarkers; Blood Gas Analysis; Case-Control Studies; Female; Humans; Hypoxia; Lact | 2009 |
A dual-emissive-materials design concept enables tumour hypoxia imaging.
Topics: Animals; Breast Neoplasms; Disease Models, Animal; Hypoxia; Lactic Acid; Mice; Nanoparticles; Neopla | 2009 |
Metabolic aspects of neonatal rat islet hypoxia tolerance.
Topics: Adenosine Triphosphate; Aging; Animals; Animals, Newborn; Calcium; Cells, Cultured; Cyclic AMP; Gluc | 2010 |
Fabrication and characterization of prosurvival growth factor releasing, anisotropic scaffolds for enhanced mesenchymal stem cell survival/growth and orientation.
Topics: Cell Culture Techniques; Cell Proliferation; Humans; Hypoxia; Insulin-Like Growth Factor I; Lactic A | 2009 |
Systemic hypoxia affects exercise-mediated antitumor cytotoxicity of natural killer cells.
Topics: Adult; Analysis of Variance; Antigens, CD; Cell Line; Cell Separation; Cells, Cultured; Cytotoxicity | 2009 |
Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes.
Topics: Adipocytes; Adipose Tissue; Antimutagenic Agents; Cells, Cultured; Cobalt; Female; Gene Expression R | 2010 |
Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts.
Topics: Animals; Benzimidazoles; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Female; Fluo | 2009 |
Training in hypoxia fails to further enhance endurance performance and lactate clearance in well-trained men and impairs glucose metabolism during prolonged exercise.
Topics: Adult; Altitude; Blood Glucose; Exercise Tolerance; Humans; Hypoxia; Lactic Acid; Male; Metabolic Cl | 2010 |
Metabolic profiling of heat or anoxic stress in mouse C2C12 myotubes using multinuclear magnetic resonance spectroscopy.
Topics: Adenosine Diphosphate; Amino Acids; Animals; Biomarkers; Cell Line; Data Interpretation, Statistical | 2010 |
Effects of acute hypoxia on metabolic and hormonal responses to resistance exercise.
Topics: Adult; Epinephrine; Exercise; Human Growth Hormone; Humans; Hydrocortisone; Hypoxia; Insulin-Like Gr | 2010 |
Acid-base balance and ventilation during sternal and lateral recumbency in field immobilized black rhinoceros (Diceros bicornis) receiving oxygen insufflation: a preliminary report.
Topics: Acid-Base Equilibrium; Animals; Animals, Wild; Azaperone; Blood Gas Analysis; Capnography; Etorphine | 2010 |
Hypothermic protection in an acute hypoxia model in rats: Acid-base and oxidant/antioxidant profiles.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Antioxidants; Arteries; Disease Models, Animal; Glutathion | 2010 |
Common phenotype of resting mouse extensor digitorum longus and soleus muscles: equal ATPase and glycolytic flux during transient anoxia.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Aerobiosis; Algorithms; Animals; Biological Transp | 2010 |
Metabolic responses of Parastacus defossus and Parastacus brasiliensis (Crustacea, Decapoda, Parastacidae) to hypoxia.
Topics: Animals; Astacoidea; Glucose; Hemolymph; Hypoxia; Lactic Acid; Lipids; Proteins; Species Specificity | 2010 |
Effect of moderate hypoxia at three acclimation temperatures on stress responses in Atlantic cod with different haemoglobin types.
Topics: Acclimatization; Animals; Gadus morhua; Hemoglobins; HSP70 Heat-Shock Proteins; Hydrocortisone; Hypo | 2010 |
Aerobic and anaerobic metabolism for the zebrafish, Danio rerio, reared under normoxic and hypoxic conditions and exposed to acute hypoxia during development.
Topics: Aerobiosis; Anaerobiosis; Animals; Body Mass Index; Heart Rate; Hypoxia; Lactic Acid; Oxygen Consump | 2010 |
Regulation of human metabolism by hypoxia-inducible factor.
Topics: Adult; Exercise; Female; Gene Expression Regulation; Humans; Hypoxia; Lactates; Lactic Acid; Male; M | 2010 |
Cardiac atria are the primary source of ANP release in hypoxia-adapted rats.
Topics: Animals; Atrial Natriuretic Factor; Body Weight; Calcium; Glucose; Heart Atria; Hydrogen-Ion Concent | 2010 |
[Treatment of anaemia of prematurity with SS-R-Hu-erythropoietin and significance of hypoxia-inducible factor].
Topics: Anemia, Neonatal; Erythrocyte Transfusion; Erythropoietin; Hematocrit; Hemoglobinometry; Humans; Hyp | 2010 |
Nitric oxide metabolites in goldfish under normoxic and hypoxic conditions.
Topics: Animals; Erythrocytes; Gills; Goldfish; Hemoglobins; Hypoxia; Lactic Acid; Nitrates; Nitric Oxide; O | 2010 |
Hypoxia stimulates lactate disposal in rainbow trout.
Topics: Anaerobiosis; Animals; Blood Glucose; Carbohydrate Metabolism; Carbon Radioisotopes; Female; Fish Di | 2010 |
Two structurally different T-type Ca 2+ channel inhibitors, mibefradil and pimozide, protect CA1 neurons from delayed death after global ischemia in rats.
Topics: Animals; Brain; CA1 Region, Hippocampal; Calcium Channel Blockers; Calcium Channels, T-Type; Cell De | 2011 |
Anoxic survival of the Pacific hagfish (Eptatretus stoutii).
Topics: Adenosine Triphosphate; Animals; Basal Metabolism; Glucose; Glycogen; Hagfishes; Hypoxia; Lactic Aci | 2011 |
The influence of glucose concentration and hypoxia on VEGF secretion by cultured retinal cells.
Topics: Animals; Cattle; Cells, Cultured; Endothelium, Vascular; Glucose; Humans; Hypoxia; Lactic Acid; Pyru | 2011 |
Effects of fasting on hypoxic ventilatory responses and the contribution of histamine H1 receptors in mice.
Topics: Animals; Basal Metabolism; Blood Glucose; Energy Metabolism; Fasting; Fatty Acids, Nonesterified; Hy | 2011 |
[Effects of ginkgolide (Gin) on cerebral water content, Na+, K(+) -ATPase activity, MDA, lactic acid of rats during acute hypoxia condition].
Topics: Animals; Brain; Female; Ginkgolides; Hypoxia; Lactic Acid; Male; Malondialdehyde; Rats; Rats, Spragu | 2003 |
Anaerobic contribution during maximal anaerobic running test: correlation with maximal accumulated oxygen deficit.
Topics: Anaerobic Threshold; Exercise Test; Humans; Hypoxia; Lactic Acid; Male; Oxygen; Oxygen Consumption; | 2011 |
Measurements of lactate in exhaled breath condensate at rest and after maximal exercise in young and healthy subjects.
Topics: Adult; Breath Tests; Exercise; Female; Humans; Hypoxia; Lactic Acid; Male; Oxygen Consumption; Young | 2010 |
The effects of temperature on the physiological response to low oxygen in Atlantic sturgeon.
Topics: Acclimatization; Animals; Blood Glucose; Chlorides; Fishes; Hypoxia; Lactic Acid; Osmolar Concentrat | 2011 |
Impact of short-term systemic hypoxia on phagocytosis, cytokine production, and transcription factor activation in peripheral blood cells.
Topics: Adult; Atmospheric Pressure; CD4-Positive T-Lymphocytes; Cytokines; Erythropoietin; Female; Fluoresc | 2011 |
Shedding of the coronary endothelial glycocalyx: effects of hypoxia/reoxygenation vs ischaemia/reperfusion.
Topics: Adenosine; Analysis of Variance; Animals; Coronary Vessels; Endothelium, Vascular; Glycocalyx; Guine | 2011 |
Anti-hypoxic activity at simulated high altitude was isolated in petroleum ether extract of Saussurea involucrata.
Topics: Adenosine Triphosphate; Alkanes; Altitude Sickness; Animals; Blood Glucose; Brain; Ca(2+) Mg(2+)-ATP | 2011 |
Lactate and the GPR81 receptor in metabolic regulation: implications for adipose tissue function and fatty acid utilisation by muscle during exercise.
Topics: Adipose Tissue, White; Carbohydrate Metabolism; Energy Metabolism; Exercise; Fatty Acids; Glucose; H | 2011 |
Combined central venous oxygen saturation and lactate as markers of occult hypoperfusion and outcome following cardiac surgery.
Topics: Aged; Biomarkers; Cardiac Surgical Procedures; Catheterization, Central Venous; Female; Humans; Hypo | 2012 |
Effect of chronic intermittent hypoxia on exercise adaptations in healthy subjects.
Topics: Adaptation, Physiological; Blood Pressure; Exercise; Exercise Tolerance; Female; Heart Rate; Hemodyn | 2011 |
Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect.
Topics: Cell Line, Tumor; Citric Acid Cycle; Fermentation; Gas Chromatography-Mass Spectrometry; Glucose; Gl | 2011 |
Maximal accumulated oxygen deficit in running and cycling.
Topics: Adult; Bicycling; Exercise Test; Exercise Tolerance; Female; Humans; Hypoxia; Lactic Acid; Male; Mus | 2011 |
FTY720-loaded poly(DL-lactide-co-glycolide) electrospun scaffold significantly increases microvessel density over 7 days in streptozotocin-induced diabetic C57b16/J mice: preliminary results.
Topics: Animals; Automation; Biocompatible Materials; Diabetes Mellitus, Experimental; Drug Delivery Systems | 2011 |
Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment.
Topics: Breast Neoplasms; Carcinoma; Cell Communication; Cell Line, Tumor; Female; Fibroblasts; Glycolysis; | 2012 |
Tissue localization of nanoparticles is altered due to hypoxia resulting in poor efficacy of curcumin nanoparticles in pulmonary hypertension.
Topics: Administration, Oral; Animals; Curcumin; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hy | 2012 |
Changes in cardiac autonomic activity during a passive 8 hour acute exposure to 5 500 m normobaric hypoxia are not related to the development of acute mountain sickness.
Topics: Adult; Altitude Sickness; Autonomic Nervous System; Heart Rate; Humans; Hypoxia; Lactic Acid; Male; | 2012 |
Regulation of human monocarboxylate transporter 4 in skeletal muscle cells: the role of protein kinase C (PKC).
Topics: Acetophenones; Base Sequence; Benzopyrans; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subuni | 2012 |
Hypoxia and exercise provoke both lactate release and lactate oxidation by the human brain.
Topics: Adult; Biological Transport, Active; Blood Flow Velocity; Brain; Cerebrovascular Circulation; Energy | 2012 |
Exceptional cardiac anoxia tolerance in tilapia (Oreochromis hybrid).
Topics: Acidosis; Adaptation, Physiological; Adenosine Triphosphate; Animals; Cardiac Output; Glycolysis; He | 2012 |
Low O2 avoidance is associated with physiological perturbation but not exhaustion in the snapper (Pagrus auratus: Sparidae).
Topics: Animals; Basal Metabolism; Behavior, Animal; Blood Glucose; Glycogen; Hematocrit; Hydrocortisone; Hy | 2012 |
[Effects of acute hypobaric hypoxia and exhaustive exercise on AMP-activated protein kinase phosphorylation in rat skeletal muscle].
Topics: Altitude; AMP-Activated Protein Kinases; Animals; Computer Simulation; Glycogen; Hypoxia; Lactic Aci | 2012 |
Lactate/pyruvate ratio as a marker of tissue hypoxia in circulatory and septic shock.
Topics: Aerobiosis; Aged; APACHE; Biomarkers; Female; Humans; Hypoxia; Lactic Acid; Male; Middle Aged; Pyruv | 2012 |
Physiological and metabolic responses to increasing work rates: relevance for exercise prescription.
Topics: Athletic Performance; Carbohydrate Metabolism; Exercise; Fatigue; Humans; Hypoxia; Lactic Acid; Mito | 1998 |
Role for NGF in augmented sympathetic nerve response to activation of mechanically and metabolically sensitive muscle afferents in rats with femoral artery occlusion.
Topics: Acid Sensing Ion Channels; Animals; Arteries; Blood Pressure; Femoral Artery; Ganglia, Spinal; Hindl | 2012 |
Infusing sodium bicarbonate suppresses hydrogen peroxide accumulation and superoxide dismutase activity in hypoxic-reoxygenated newborn piglets.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Animals, Newborn; Blood Gas Analysis; Catalase; Cerebral C | 2012 |
Red blood cell transfusion affects microdialysis-assessed interstitial lactate/pyruvate ratio in critically ill patients with late sepsis.
Topics: Adipose Tissue; Aged; Blood Specimen Collection; Erythrocyte Transfusion; Extracellular Fluid; Femal | 2012 |
Increased oxidative stress and anaerobic energy release, but blunted Thr172-AMPKα phosphorylation, in response to sprint exercise in severe acute hypoxia in humans.
Topics: Acute Disease; Adult; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Anaerobic | 2012 |
The frontal lobe and thalamus have different sensitivities to hypoxia-hypotension after traumatic brain injury: a microdialysis study in rats.
Topics: Animals; Blood Pressure; Brain Injuries; Cerebrovascular Circulation; Energy Metabolism; Frontal Lob | 2012 |
Hypoxaemia-induced catecholamine secretion from adrenal chromaffin cells inhibits glucose-stimulated hyperinsulinaemia in fetal sheep.
Topics: Adrenal Glands; Animals; Blood Glucose; Chromaffin Cells; Epinephrine; Female; Fetus; Hyperinsulinis | 2012 |
Intraluminal intestinal microdialysis detects markers of hypoxia and cell damage in experimental necrotizing enterocolitis.
Topics: Animals; Biomarkers; Colon, Sigmoid; Enterocolitis, Necrotizing; Glucose; Glycerol; Hypoxia; Ileum; | 2012 |
Metabolic adaptations may counteract ventilatory adaptations of intermittent hypoxic exposure during submaximal exercise at altitudes up to 4000 m.
Topics: Adaptation, Physiological; Altitude; Analysis of Variance; Baroreflex; Blood Gas Analysis; Carbon Di | 2012 |
Temporal dynamics of lactate concentration in the human brain during acute inspiratory hypoxia.
Topics: Acute Disease; Adult; Brain; Female; Humans; Hypoxia; Hypoxia, Brain; Lactates; Lactic Acid; Magneti | 2013 |
Fetal sheep left ventricle is more sensitive than right ventricle to progressively worsening hypoxemia and acidemia.
Topics: Acidosis; Animals; Animals, Inbred Strains; Disease Models, Animal; Disease Progression; Female; Fin | 2013 |
Excess post-hypoxic oxygen consumption is independent from lactate accumulation in two cyprinid fishes.
Topics: Animals; Carps; Ethanol; Gills; Hypoxia; Lactic Acid; Muscles; Oxygen; Oxygen Consumption | 2013 |
Developmental changes in cardiac recovery from anoxia-reoxygenation.
Topics: Animals; Bradycardia; Chick Embryo; Extracellular Space; Heart; Heart Block; Heart Rate; Hydrogen-Io | 2002 |
Physiological responses to prolonged aquatic hypoxia in the Queensland lungfish Neoceratodus forsteri.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Erythrocytes; Fishes; Fresh Water; Hematocrit | 2002 |
Is lactate a mediator of hypoxia-induced anapyrexia?
Topics: Animals; Body Temperature; Body Temperature Regulation; Dichloroacetic Acid; Fever; Hypoxia; Lactic | 2002 |
Detrimental effects of nicotine and endotoxin in the newborn piglet brain during severe hypoxemia.
Topics: Animals; Animals, Newborn; Blood Pressure; Brain Diseases; Corpus Striatum; Endotoxins; Escherichia | 2002 |
Cytokines induce HIF-1 DNA binding and the expression of HIF-1-dependent genes in cultured rat enterocytes.
Topics: Animals; Blotting, Western; Cells, Cultured; Culture Media, Conditioned; Cytokines; DNA; DNA-Binding | 2003 |
Increased skeletal muscle lactate production following hemorrhagic shock in rats.
Topics: Animals; Cell Membrane Permeability; Hypoxia; Lactic Acid; Muscle, Skeletal; Rats; Shock, Hemorrhagi | 2002 |
Effects of fasting and hypoxic preconditioning on the hypoxic-reoxygenated ventricular strips of the rat heart.
Topics: Acyl Coenzyme A; Analysis of Variance; Animals; Carnitine; Fasting; Heart Ventricles; Hypoxia; Ische | 2002 |
Intraperitoneal microdialysis for detection of splanchnic metabolic disorders.
Topics: Animals; Ascitic Fluid; Cryoprotective Agents; Disease Models, Animal; Extracellular Space; Gastroin | 2002 |
[Effects of +Gx stress on contractility of rat diaphragm and its mechanism].
Topics: Acceleration; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Diaph | 2002 |
Pyruvate reverses metabolic effects produced by hypoxia in glioma and hepatoma cell cultures.
Topics: Animals; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Glioma; Glucose; Humans; Hypoxia | 2002 |
Comparison between the effects of chronic and acute hypoxemia on muscle afferent activities from the tibialis anterior muscle.
Topics: Action Potentials; Afferent Pathways; Animals; Chronic Disease; Electric Stimulation; Evoked Potenti | 2003 |
Preexercise hypervolemia does not affect arterial hypoxemia in Thoroughbreds performing short-term high-intensity exercise.
Topics: Animal Husbandry; Animals; Arteries; Blood Proteins; Blood Volume; Body Temperature; Carbon Dioxide; | 2003 |
Biochemical tissue monitoring during hypoxia and reoxygenation.
Topics: Acidosis; Animals; Blood Pressure; Hypoxia; Lactic Acid; Liver; Male; Microdialysis; Muscle, Skeleta | 2003 |
Hindlimb glucose and lactate metabolism during umbilical cord compression and acute hypoxemia in the late-gestation ovine fetus.
Topics: Acid-Base Equilibrium; Acute Disease; Animals; Blood Gas Analysis; Blood Glucose; Female; Femoral Ar | 2003 |
Variability in hypoxia-induced corneal swelling is associated with variability in corneal metabolism and endothelial function.
Topics: Acidosis; Adult; Cell Count; Contact Lenses; Cornea; Corneal Edema; Endothelium, Corneal; Female; Hu | 2003 |
Effects of the oral contraceptive pill cycle on physiological responses to hypoxic exercise.
Topics: Adult; Analysis of Variance; Blood Glucose; Blood Pressure; Contraceptives, Oral; Epinephrine; Exerc | 2003 |
[Monitoring of lactate level and oxygen status for diagnosis and correction of hypoxia in critically ill patients (a lecture)].
Topics: Critical Illness; Hemostasis; Humans; Hypoxia; Lactic Acid; Monitoring, Physiologic; Oxygen | 2003 |
The contribution of glycolytic and oxidative pathways to retinal photoreceptor function.
Topics: Aerobiosis; Anaerobiosis; Animals; Dark Adaptation; Drug Combinations; Electroretinography; Glucose; | 2003 |
Orchidopexy or orchidectomy for preventing tissue hypoxia in contralateral testis following induction of ipsilateral abdominal testis associated with vas deferens obstruction.
Topics: Animals; Cryptorchidism; Hypoxanthine; Hypoxia; Lactic Acid; Male; Models, Animal; Orchiectomy; Oxid | 2003 |
Effects of temperature and extracellular pH on metabolites: kinetics of anaerobic metabolism in resting muscle by 31P- and 1H-NMR spectroscopy.
Topics: Animals; Energy Metabolism; Glycolysis; Hydrogen; Hydrogen-Ion Concentration; Hypoxia; Lactic Acid; | 2003 |
Energy cost of contraction in rat urinary bladder smooth muscle during anoxia.
Topics: Adenosine Triphosphate; Aerobiosis; Anaerobiosis; Animals; Energy Metabolism; Hypoxia; In Vitro Tech | 2003 |
Mapping of ATP, glucose, glycogen, and lactate concentrations within the arterial wall.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Carotid Arteries; Cryopreservation; Energy Me | 2003 |
Lactate sequestration by osteoderms of the broad-nose caiman, Caiman latirostris, following capture and forced submergence.
Topics: Acidosis, Lactic; Alligators and Crocodiles; Analysis of Variance; Animals; Bone and Bones; Calcium; | 2003 |
[Effect of tissue anoxia on lactic acid in blood].
Topics: Humans; Hypoxia; Lactic Acid | 1952 |
Lactic acid content in human venous blood during hypoxia at high altitude.
Topics: Altitude; Humans; Hypoxia; Lactic Acid | 1957 |
Relationships of pyruvate and lactate during anaerobic metabolism. II. Exercise and formation of O-debt.
Topics: Exercise; Hypoxia; Lactates; Lactic Acid; Metabolism; Pyruvates; Pyruvic Acid | 1958 |
Relationships of pyruvate and lactate during anaerobic metabolism. III. Effect of breathing low-oxygen gases.
Topics: Gases; Hypoxia; Lactates; Lactic Acid; Metabolism; Oxygen; Pyruvates; Pyruvic Acid | 1958 |
Postmortem diagnosis of hypoxia by means of brain lactic acid concentration.
Topics: Brain; Hemorrhage; Humans; Hypoxia; Lactic Acid | 1958 |
Relationship among recovery oxygen, oxygen missed, lactate production and lactate removal during and following severe hypoxia in the unanesthetized dog.
Topics: Animals; Dogs; Hypoxia; Lactates; Lactic Acid; Metabolism; Oxygen | 1958 |
Relation of hypoxemia and/or hypocapnia to lactic acid content of brain and cardiovascular response.
Topics: Brain; Carbon Dioxide; Cardiovascular Physiological Phenomena; Cardiovascular System; Hemorrhage; Hu | 1958 |
Lactic acid concentration of brain tissues of dogs exposed to hypoxemia and/or hypocapnia.
Topics: Animals; Brain; Carbon Dioxide; Dogs; Hypocapnia; Hypoxia; Lactic Acid; Neurochemistry | 1958 |
[Glucose, lactic acid, ATP and ADP concentrations in the arterial and venous coronary blood of dogs in oxygen deficiency].
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arteries; Blood Glucose | 1961 |
Significance of elevated lactic acid in the postmortem brain.
Topics: Autopsy; Brain; Brain Chemistry; Humans; Hypoxia; Lactates; Lactic Acid | 1960 |
Lactic acid accumulation as a cause of hypoxia-induced malformations in the chick embryo.
Topics: Animals; Chick Embryo; Congenital Abnormalities; Hypoxia; Lactates; Lactic Acid | 1961 |
[Changes of serum lactic and pyruvic acid in hypoxia and hypercapnea, especially effects of respiratory changes of blood PH upon lactic acid level].
Topics: Carbon Dioxide; Hydrogen-Ion Concentration; Hypoxia; Lactates; Lactic Acid; Pyruvates; Pyruvic Acid | 1962 |
The inhibitory influence of lactic acid on pressor effects of sympathomimetic amines.
Topics: Blood Pressure; Blood Pressure Determination; Epinephrine; Hypoxia; Lactates; Lactic Acid; Norepinep | 1963 |
Regulation of glycogenolysis in muscle. Effects of glucagon and anoxia on lactate production, glycogen content, and phosphorylase activity in the perfused isolated rat heart.
Topics: Animals; Carbohydrate Metabolism; Glucagon; Glycogen; Glycogenolysis; Hypoxia; Lactates; Lactic Acid | 1963 |
EXCESS LACTATE: AN INDEX OF REVERSIBILITY OF SHOCK IN HUMAN PATIENTS.
Topics: Animals; Blood Chemical Analysis; Dogs; Humans; Hypoxia; Lactates; Lactic Acid; Metabolism; Oxygen; | 1964 |
EFFECT OF ANOXIA ON LACTATE/PYRUVATE AND ATP/ADP RATIOS IN ADULT AND FETAL GUINEA PIG LIVER.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Fetus; Guinea Pigs; Hyp | 1964 |
BLOOD LACTATE, PYRUVATE AND LACTATE-PYRUVATE RATIOS IN CONGENITAL HEART DISEASE.
Topics: Blood Chemical Analysis; Child; Heart Defects, Congenital; Humans; Hypoxia; Lactates; Lactic Acid; N | 1964 |
TRANSIENT ARTERIAL LACTIC ACID CHANGES IN UNANESTHETIZED DOGS AT 21,000 FEET.
Topics: Acclimatization; Altitude; Animals; Bicarbonates; Blood Chemical Analysis; Blood Gas Analysis; Dogs; | 1964 |
PROLONGED ANOXIC SURVIVAL DUE TO ANOXIA PRE-EXPOSURE: BRAIN ATP, LACTATE, AND PYRUVATE.
Topics: Adenosine Triphosphate; Brain; Brain Chemistry; Carbohydrate Metabolism; Glucose; Glycolysis; Hypoxi | 1964 |
THE EFFECT OF HYPOXIA ON GAS EXCHANGE AND ARTERIAL LACTATE AND PYRUVATE CONCENTRATION DURING MODERATE EXERCISE IN MAN.
Topics: Arteries; Blood; Carbon Dioxide; Exercise; Humans; Hydrogen-Ion Concentration; Hyperventilation; Hyp | 1965 |
DISTRIBUTION AND GRADIENT OF LACTATE BETWEEN BLOOD AND HEART MUSCLE.
Topics: Biological Transport; Blood; Dogs; Hypoxia; Injections; Injections, Intravenous; Lactates; Lactic Ac | 1965 |
THE ACID-BASE STATUS IN CYANOTIC CONGENITAL HEART DISEASE.
Topics: Acid-Base Equilibrium; Acidosis; Blood Gas Analysis; Cardiac Output; Heart Defects, Congenital; Huma | 1965 |
THE CLINICAL SIGNIFICANCE OF ELEVATED BLOOD LACTATE.
Topics: Acidosis; Acidosis, Lactic; Blood; Chemical Phenomena; Chemistry; Geriatrics; Humans; Hypertension; | 1965 |
Lactic acid in blood after various combinations of exercise and hypoxia.
Topics: Dermatologic Agents; Exercise; Humans; Hypoxia; Lactates; Lactic Acid; Physical Exertion | 1962 |
Effects of live high, train low hypoxic exposure on lactate metabolism in trained humans.
Topics: Acid-Base Equilibrium; Adult; Blood Glucose; Fatty Acids, Nonesterified; Ferritins; Hematocrit; Hemo | 2004 |
Lactate as a modulator of hypoxia-induced hyperventilation.
Topics: Acidosis, Lactic; Animals; Dichloroacetic Acid; Enzyme Inhibitors; Hyperventilation; Hypoxia; Lactic | 2003 |
Parameters of adenylate pool as predictors of energy metabolism disturbances in hepatocytes during hypoxia.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Energy Metabolism; | 2003 |
Performance of the neonatal pig heart subjected to oxygen insufficiency.
Topics: Animals; Animals, Newborn; Aorta; Blood Pressure; Coronary Circulation; Diastole; Glucose; Glycolysi | 2004 |
Polymers for induction of revascularization in the rat fascial flap: application of vascular endothelial growth factor and pancreatic islet cells.
Topics: Animals; Cell Line; Chitin; Chitosan; Fascia; Humans; Hypoxia; Immunohistochemistry; Insulin; Islets | 2003 |
Persistence of the lactate paradox over 8 weeks at 3,800 m.
Topics: Acclimatization; Adult; Altitude; Analysis of Variance; California; Epinephrine; Exercise; Exercise | 2003 |
Lactate and glucose as energy substrates during, and after, oxygen deprivation in rat hippocampal acute and cultured slices.
Topics: Amino Acids; Animals; Cell Hypoxia; Cell Survival; Dose-Response Relationship, Drug; Drug Interactio | 2003 |
Physiology of hibernation in Rana pipiens: metabolic rate, critical oxygen tension, and the effects of hypoxia on several plasma variables.
Topics: Analysis of Variance; Animals; Blood Glucose; Fresh Water; Hibernation; Hydrogen-Ion Concentration; | 2004 |
Effects of acute hypoxia on the determination of anaerobic threshold using the heart rate-work rate relationships during incremental exercise tests.
Topics: Acute Disease; Adult; Anaerobic Threshold; Carbon Dioxide; Exercise Test; Heart Rate; Humans; Hypoxi | 2004 |
Preconditioning stimuli do not benefit the myocardium of hypoxia-tolerant rainbow trout (Oncorhynchus mykiss).
Topics: Analysis of Variance; Animals; Cardiac Output; Epinephrine; Glycogen; Heart; Heart Rate; Hypoxia; Is | 2004 |
Occult hypoperfusion is associated with increased mortality in hemodynamically stable, high-risk, surgical patients.
Topics: Adult; Aged; Biomarkers; Critical Illness; Female; Hemodynamics; Humans; Hypoxia; Intensive Care Uni | 2004 |
Effect of nutrient deprivation on the viability of intervertebral disc cells.
Topics: Animals; Cattle; Cell Survival; Cells, Cultured; Chondrocytes; Energy Metabolism; Glucose; Hydrogen- | 2004 |
Influence of chronic hypoxemia on peripheral muscle function and oxidative stress in humans.
Topics: Aged; Chronic Disease; Electromyography; Evoked Potentials; Female; Glutathione; Humans; Hypoxia; La | 2004 |
The regulation and importance of glucose uptake in the isolated Atlantic cod heart: rate-limiting steps and effects of hypoxia.
Topics: Analysis of Variance; Animals; Biological Transport, Active; Cytochalasin B; Deoxyglucose; Fishes; G | 2004 |
Force development, energy state and ATP production of cardiac muscle from turtles and trout during normoxia and severe hypoxia.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Hydrolysis; Hypoxia; Lactic Acid; Myocardial | 2004 |
Effects of swimming on metabolic recovery from anoxia in the painted turtle.
Topics: Analysis of Variance; Animals; Blood Chemical Analysis; Energy Metabolism; Hypoxia; Lactic Acid; Oxy | 2004 |
Lactate metabolism at high altitude.
Topics: Acclimatization; Altitude; Exercise; Female; Humans; Hypoxia; Lactic Acid; Male; Research Design | 2004 |
Patterns of energy substrates during ischemia measured in the brain by microdialysis.
Topics: Adult; Brain Injuries; Brain Ischemia; Female; Glasgow Coma Scale; Glucose; Glutamic Acid; Humans; H | 2004 |
Loss of skeletal muscle HIF-1alpha results in altered exercise endurance.
Topics: Adenosine Triphosphate; Alleles; Animals; Creatine Kinase; Crosses, Genetic; Gene Deletion; Gene Exp | 2004 |
Time-dependent expression of heat shock proteins 70 and 90 in tissues of the anoxic western painted turtle.
Topics: Analysis of Variance; Animals; Blood Glucose; Blotting, Western; Brain; Diving; Female; HSP70 Heat-S | 2004 |
Effects of ephedrine and phenylephrine on uterine and placental circulations and fetal outcome following fetal hypoxaemia and epidural-induced hypotension in a sheep model.
Topics: Acid-Base Equilibrium; Adrenergic alpha-Agonists; Anesthesia, Epidural; Anesthesia, Obstetrical; Ani | 2004 |
A novel cancer therapy: combined liposomal hypoxia inducible factor 1 alpha antisense oligonucleotides and an anticancer drug.
Topics: Apoptosis; Caspases; Doxorubicin; Drug Carriers; Drug Combinations; Drug Delivery Systems; Female; H | 2004 |
ANT2 expression under hypoxic conditions produces opposite cell-cycle behavior in 143B and HepG2 cancer cells.
Topics: Adenine Nucleotide Translocator 2; Adenine Nucleotide Translocator 3; Gene Expression Regulation, Ne | 2005 |
Cardiorespiratory and tissue adenosine responses to hypoxia and reoxygenation in the short-horned sculpin Myoxocephalus scorpius.
Topics: Adenosine; Animals; Brain; Calcium; Chromatography, High Pressure Liquid; Fishes; Hypoxia; Lactic Ac | 2004 |
Exercise with the intensity of the individual anaerobic threshold in acute hypoxia.
Topics: Adult; Altitude; Anaerobic Threshold; Blood Glucose; Epinephrine; Exercise; Exercise Test; Heart Rat | 2004 |
Ontogenetic changes and developmental adjustments in lactate dehydrogenase isozymes of an obligate air-breathing fish Channa punctatus during deprivation of air access.
Topics: Adaptation, Physiological; Air; Animals; Asphyxia; Fishes; Hypoxia; Isoenzymes; Kinetics; L-Lactate | 2005 |
Production of organic acids by Corynebacterium glutamicum under oxygen deprivation.
Topics: Corynebacterium glutamicum; Hypoxia; Lactic Acid; Succinic Acid | 2005 |
Hypoxia/reoxygenation reduces microvascular endothelial cell coupling by a tyrosine and MAP kinase dependent pathway.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Connexin 43; Electric Conductivity; Endothelial Ce | 2005 |
[Effect of high-oxygen water on enhancing anoxia endurance and anti-fatigue function and the possible mechanism].
Topics: Animals; Fatigue; Hypoxia; Hypoxia, Brain; Lactic Acid; Male; Mice; Muscle, Skeletal; Oxygen; Oxygen | 2005 |
Effects of ischaemia-mimetic factors on isolated rat ventricular myocytes.
Topics: Acidosis; Animals; Glucose; Heart Ventricles; Hypoxia; In Vitro Techniques; Lactic Acid; Male; Myoca | 2005 |
[Effect of intermittent hypoxic training on indices of adaptation to hypoxia in rats during physical exertion].
Topics: Adaptation, Physiological; Animals; Hypoxia; Lactic Acid; Male; Mitochondria, Muscle; Muscle, Skelet | 2004 |
Effect of chronic hypoxia during embryonic development on physiological functioning and on hatching and post-hatching parameters related to ascites syndrome in broiler chickens.
Topics: Altitude; Animals; Ascites; Chick Embryo; Chickens; Corticosterone; Hypoxia; Lactic Acid; Ovum; Poul | 2004 |
Role of hypoxia-induced anorexia and right ventricular hypertrophy on lactate transport and MCT expression in rat muscle.
Topics: Animals; Anorexia; Biological Transport; Body Weight; Hematocrit; Hypertrophy, Right Ventricular; Hy | 2005 |
Metabolic adjustments in two Amazonian cichlids exposed to hypoxia and anoxia.
Topics: Adaptation, Physiological; Anaerobic Threshold; Animals; Cichlids; Glycogen; Hypoxia; L-Lactate Dehy | 2005 |
Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke.
Topics: Anesthesia; Animals; Brain; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Glutamic Acid; | 2005 |
Growth restriction and the cerebral metabolic response to acute hypoxia of chick embryos in-ovo: a proton magnetic resonance spectroscopy study.
Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Aspartic Acid; Cerebellum; Chick Embryo; Fetal Hypoxia; Hyp | 2005 |
Exercise performance in hypoxia after novel erythropoiesis stimulating protein treatment.
Topics: Adult; Altitude; Erythropoiesis; Exercise; Female; Humans; Hypoxia; Lactic Acid; Male; Oxygen Consum | 2006 |
Limited oxygen diffusion accelerates fatigue development in mouse skeletal muscle.
Topics: Action Potentials; Animals; Biological Transport; Calcium; Diffusion; Hypoxia; Lactic Acid; Male; Mi | 2006 |
Plasma lactate and glucose flushes following burst swimming in silver trevally (Pseudocaranx dentex: Carangidae) support the "releaser" hypothesis.
Topics: Animals; Blood Glucose; Hypoxia; Lactic Acid; Muscles; Perciformes; Physical Exertion; Swimming | 2006 |
Excitatory amino acid release and electrocortical brain activity after hypoxemia in near-term lambs.
Topics: Animals; Animals, Newborn; Aspartic Acid; Blood Glucose; Brain; Electroencephalography; Female; Gest | 2006 |
Effect of acute hypoxia on maximal oxygen uptake and maximal performance during leg and upper-body exercise in Nordic combined skiers.
Topics: Acute Disease; Adult; Biopsy, Fine-Needle; Ergometry; Heart Rate; Humans; Hypoxia; Lactic Acid; Leg; | 2006 |
Sea-level performance in runners using altitude tents: a field study.
Topics: Adult; Altitude; Camping; Case-Control Studies; Equipment and Supplies; Exercise Test; Fatigue; Fema | 2005 |
Persistent suppression of resting energy expenditure after acute hypoxia.
Topics: Adult; Blood Glucose; Cross-Over Studies; Double-Blind Method; Energy Metabolism; Epinephrine; Gluco | 2006 |
Reexamining the hyperglycemic pseudohypoxia hypothesis of diabetic oculopathy.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Animals; Cell Culture Techniques; Diabetes Mellitus, Exp | 2006 |
Arterial oxygenation influences central motor output and exercise performance via effects on peripheral locomotor muscle fatigue in humans.
Topics: Adult; Electromyography; Humans; Hyperoxia; Hypoxia; Lactic Acid; Locomotion; Male; Motor Cortex; Mo | 2006 |
Force development at elevated [Mg2+]o and [K+]o in myocardium from the freshwater turtle (Trachemys scripta) and influence of factors associated with hibernation.
Topics: Acidosis; Animals; Calcium; Epinephrine; Heart; Hibernation; Hypoxia; In Vitro Techniques; Lactic Ac | 2006 |
Effect of acute severe hypoxia on peripheral fatigue and endurance capacity in healthy humans.
Topics: Adult; Dyspnea; Electromagnetic Fields; Exercise; Exercise Test; Femoral Nerve; Humans; Hypoxia; Lac | 2007 |
Comparative shell buffering properties correlate with anoxia tolerance in freshwater turtles.
Topics: Animals; Buffers; Carbon Dioxide; Fresh Water; Hydrogen-Ion Concentration; Hypoxia; Lactic Acid; Min | 2007 |
The impact of hypoxia on in vivo glucose uptake in a hypoglycemic fish, Myoxocephalus scorpius.
Topics: Adenosine; Animals; Atropine; Blood Glucose; Brain Chemistry; Carbohydrate Metabolism; Cardiac Outpu | 2007 |
Sex differences in energy metabolism and performance of teleost cardiac tissue.
Topics: Animals; Body Weight; Electric Stimulation; Energy Metabolism; Epinephrine; Fatty Acids; Female; Glu | 2007 |
Selected biochemical variables in a model of neonatal anoxia in rats.
Topics: Acetylglucosaminidase; Animals; Animals, Newborn; Biomarkers; Brain Chemistry; Disease Models, Anima | 2006 |
Lactate uptake by skeletal bone in anoxic turtles, Trachemys scripta.
Topics: Acidosis, Respiratory; Animals; Bone and Bones; Buffers; Cold Temperature; Hypoxia; Lactic Acid; Tur | 2007 |
Fluid resuscitation with hemoglobin-vesicle solution does not increase hypoxia or inflammatory responses in moderate hemorrhagic shock.
Topics: Animals; Blood Pressure; Blood Substitutes; Hemoglobins; Hypoxia; Inflammation; Isotonic Solutions; | 2006 |
Metabolic and ionoregulatory responses of the Amazonian cichlid, Astronotus ocellatus, to severe hypoxia.
Topics: Adaptation, Physiological; Adenosine Triphosphate; Animals; Blood Glucose; Cichlids; Creatine; Eryth | 2007 |
Grave acidosis after severe anaphylactic bronchospasm: friend or foe?
Topics: Acidosis; Adult; Anaphylaxis; Anti-Inflammatory Agents; Asthma; Blood Gas Analysis; Blood Glucose; B | 2007 |
Myocardial lactate deprivation is associated with decreased cardiovascular performance, decreased myocardial energetics, and early death in endotoxic shock.
Topics: Analysis of Variance; Animals; Coronary Circulation; Energy Metabolism; Epinephrine; Glycolysis; Hyp | 2007 |
Effect of prior heavy exercise on muscle deoxygenation kinetics at the onset of subsequent heavy exercise.
Topics: Adult; Algorithms; Carbon Dioxide; Data Interpretation, Statistical; Exercise; Female; Heart Rate; H | 2007 |
Regulation of 2-deoxy-D-glucose transport, lactate metabolism, and MMP-2 secretion by the hypoxia mimetic cobalt chloride in articular chondrocytes.
Topics: Animals; Biological Transport, Active; Cartilage, Articular; Cells, Cultured; Chondrocytes; Cobalt; | 2006 |
Taurine as a marker for foetal wellbeing?
Topics: Amino Acids; Animals; Biomarkers; Disease Models, Animal; Female; Fetal Death; Fetal Development; Fe | 2007 |
Protective effect of Portulaca oleracea extracts on hypoxic nerve tissue and its mechanism.
Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Hypoxia; L-Lactate Dehydrogenase; Lactic | 2007 |
Effects of temperature on anoxic submergence: skeletal buffering, lactate distribution, and glycogen utilization in the turtle, Trachemys scripta.
Topics: Acclimatization; Acid-Base Equilibrium; Animals; Bicarbonates; Blood Glucose; Bone and Bones; Calciu | 2007 |
An in vitro system to evaluate the effects of ischemia on survival of cells used for cell therapy.
Topics: Animals; Cell Survival; Collagen Type I; Glucose; Hypoxia; In Vitro Techniques; Lactic Acid; Mesench | 2007 |
Flexibility in energy metabolism supports hypoxia tolerance in Drosophila flight muscle: metabolomic and computational systems analysis.
Topics: Acetates; Adaptation, Physiological; Adenosine Triphosphate; Alanine; Animals; Computational Biology | 2007 |
Temporal differences in the influence of ischemic factors and deformation on the metabolism of engineered skeletal muscle.
Topics: Animals; Cell Line; Cell Shape; Cell Survival; Disease Models, Animal; Glucose; Hydrogen-Ion Concent | 2007 |
Effects of acute moderate hypoxia on anaerobic capacity in endurance-trained runners.
Topics: Acclimatization; Adult; Altitude; Ammonia; Anaerobic Threshold; Atmospheric Pressure; Exercise Test; | 2007 |
The hemodynamic effects of dobutamine during reoxygenation after hypoxia: a dose-response study in newborn pigs.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Blood Pressure; Cardiac Output; Dobutamine; Dose-Res | 2007 |
Extreme anoxia tolerance in embryos of the annual killifish Austrofundulus limnaeus: insights from a metabolomics analysis.
Topics: Amino Acids; Animals; Embryo, Nonmammalian; gamma-Aminobutyric Acid; Hypoxia; Killifishes; Lactic Ac | 2007 |
Arabidopsis NIP2;1, a major intrinsic protein transporter of lactic acid induced by anoxic stress.
Topics: Anaerobiosis; Aquaporins; Arabidopsis Proteins; Gene Expression Regulation, Plant; Hypoxia; Lactic A | 2007 |
Muscle fatigue increases the probability of developing hyperalgesia in mice.
Topics: Animals; Carbon Dioxide; Cumulative Trauma Disorders; Disease Models, Animal; Dose-Response Relation | 2007 |
Preexisting hypoxia is associated with a delayed but more sustained rise in T/QRS ratio during prolonged umbilical cord occlusion in near-term fetal sheep.
Topics: Amniotic Fluid; Animals; Blood Gas Analysis; Blood Glucose; Blood Pressure; Carotid Arteries; Data I | 2007 |
The novel hemoglobin-based oxygen carrier HRC 101 improves survival in murine sickle cell disease.
Topics: Albumins; Anemia, Sickle Cell; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Blood Substitut | 2007 |
ICVTS on-line discussion A. Further testing is warranted to detect more subtle degrees...
Topics: Anaerobic Threshold; Animals; Cardiopulmonary Bypass; Coronary Artery Bypass; Coronary Artery Diseas | 2007 |
Prediction of the susceptibility to AMS in simulated altitude.
Topics: Acclimatization; Acute Disease; Altitude; Altitude Sickness; Exercise; Humans; Hypercapnia; Hyperven | 2008 |
The influence of anoxia on lactate utilization in man after prolonged muscular work.
Topics: Humans; Hypoxia; Lactates; Lactic Acid; Male; Muscles; Oxygen | 1949 |
Oxidative stress and matrix metalloproteinase-9 activity in the liver after hypoxia and reoxygenation with 21% or 100% oxygen in newborn piglets.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Alanine Transaminase; Animal | 2008 |
Effect of seabuckthorn leaf extracts on circulating energy fuels, lipid peroxidation and antioxidant parameters in rats during exposure to cold, hypoxia and restraint (C-H-R) stress and post stress recovery.
Topics: Animals; Antioxidants; Blood Glucose; Fatty Acids, Nonesterified; Hippophae; Hypothermia; Hypoxia; L | 2008 |
Extracellular pH defense against lactic acid in untrained and trained altitude residents.
Topics: Acclimatization; Acid-Base Equilibrium; Acidosis, Lactic; Adaptation, Physiological; Adult; Altitude | 2008 |
Intrapulmonary shunting and pulmonary gas exchange during normoxic and hypoxic exercise in healthy humans.
Topics: Adolescent; Adult; Blood Gas Analysis; Body Temperature; Data Interpretation, Statistical; Echocardi | 2008 |
Xenon/hypothermia neuroprotection regimes in spontaneously breathing neonatal rats after hypoxic-ischemic insult: the respiratory and sedative effects.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Blood Glucose; Body Temperature; Carbon Dioxide; | 2008 |
Increased aerobic glycolysis through beta2 stimulation is a common mechanism involved in lactate formation during shock states.
Topics: Animals; Epinephrine; Glycolysis; Hypoxia; Lactic Acid; Male; Oxygen; Rats; Rats, Wistar; Receptors, | 2008 |
Aerobic glycolysis in cancers: implications for the usability of oxygen-responsive genes and fluorodeoxyglucose-PET as markers of tissue hypoxia.
Topics: Aerobiosis; Animals; Cell Line, Tumor; Fluorodeoxyglucose F18; Glycolysis; Humans; Hypoxia; Immunohi | 2008 |
Paclitaxel-loaded poly(D,L-lactide-co-glycolide) nanoparticles for radiotherapy in hypoxic human tumor cells in vitro.
Topics: Antineoplastic Agents, Phytogenic; Cell Cycle; Cell Line, Tumor; Cell Survival; Coculture Techniques | 2008 |
Delayed hypothermia as selective head cooling or whole body cooling does not protect brain or body in newborn pig subjected to hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Anticonvulsants; Calcium; Cardiotonic Agents; Disease Models, Animal; Fem | 2008 |
One-stop-shop tumor imaging: buy hypoxia, get lactate free.
Topics: Animals; Electron Spin Resonance Spectroscopy; Hypoxia; Lactic Acid; Magnetic Resonance Imaging; Mic | 2008 |
Evidence that reduced skeletal muscle recruitment explains the lactate paradox during exercise at high altitude.
Topics: Acclimatization; Altitude; Animals; Brain; Cardiac Output; Exercise; Humans; Hypoxia; Lactic Acid; M | 2009 |
The role of hepatic glycogen stores in anaerobic metabolism in rats.
Topics: Anaerobiosis; Animals; Blood Glucose; Carbon Monoxide Poisoning; Cyanides; Energy Metabolism; Hypoxi | 1984 |
On the role of cyclic nucleotides in the regulation of cardiac contractility and glycolysis during hypoxia.
Topics: Animals; Cyclic AMP; Cyclic GMP; Glycolysis; Hypoxia; Lactates; Lactic Acid; Male; Myocardial Contra | 1981 |
Sodium nitroprusside inhibits lactate formation in rat atria: is cyclic GMP involved?
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Ferricyanides; Glycolysis; Hypothermia; Hypox | 1983 |
Studies on experimental growth retardation in sheep. The effects of maternal hypoxaemia.
Topics: Adrenocorticotropic Hormone; Animals; Blood Glucose; Endometrium; Female; Fetal Growth Retardation; | 1983 |
The effects of cyclic AMP and cyclic GMP on redox state and energy state in hypoxic rat atria.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenine Nucleotides; Animals; Cyclic GMP; Energy Metabolism; | 1984 |
Biological time-related changes in tolerance of male rats to hypoxia--I. Survival rate and carbohydrate metabolism.
Topics: Activity Cycles; Animals; Blood Glucose; Brain Chemistry; Carbohydrate Metabolism; Circadian Rhythm; | 1984 |
On the seemingly diminished CO2-Bohr effect in hypoxic chemodenervated rabbits.
Topics: 2,3-Diphosphoglycerate; Animals; Carbon Dioxide; Chemical Phenomena; Chemistry, Physical; Diffusion; | 1984 |
Small bowel and liver gas tensions during intravenous vasopressin infusion and 60% oxygen ventilation.
Topics: Animals; Carbon Dioxide; Hypoxia; Intestine, Small; Lactates; Lactic Acid; Liver; Oxygen; Swine; Vas | 1984 |
Trends in continuous metabolic monitoring during experimental fetal distress.
Topics: Animals; Carbon Dioxide; Dogs; Electrocardiography; Female; Fetal Blood; Fetal Distress; Fetal Monit | 1984 |
Splanchnic vasomotor and metabolic adjustments to hypoxia and exercise in humans.
Topics: Adult; Blood Pressure; Epinephrine; Heart Rate; Humans; Hypoxia; Indocyanine Green; Lactates; Lactic | 1984 |
Metabolic consequences of induced hypoxia in newborn lambs.
Topics: Animals; Animals, Newborn; Blood Glucose; Body Temperature; Fatty Acids, Nonesterified; Hematocrit; | 1984 |
Effect of an extract of Ginkgo biloba on rat brain energy metabolism in hypoxia.
Topics: Animals; Brain; Energy Metabolism; Hypoxia; Lactates; Lactic Acid; Male; Plant Extracts; Plants, Med | 1984 |
Role of glycolytic products in damage to ischemic myocardium. Dissociation of adenosine triphosphate levels and recovery of function of reperfused ischemic hearts.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Calcium; Coronary C | 1984 |
Different effects of acute ischemia and anoxia on the canine myocardium.
Topics: Acute Disease; Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Disease; Dogs; Female | 1984 |
[The effect of Co-enzyme Q10 on lactate metabolism during resuscitation from anoxia].
Topics: Animals; Coenzymes; Energy Metabolism; Hypoxia; Lactates; Lactic Acid; Rabbits; Resuscitation; Ubiqu | 1984 |
High-resolution 1H nuclear magnetic resonance study of cerebral hypoxia in vivo.
Topics: Animals; Cerebral Cortex; Heart Rate; Hypoxia; Kinetics; Lactates; Lactic Acid; Magnetic Resonance S | 1983 |
Detection of cerebral lactate in vivo during hypoxemia by 1H NMR at relatively low field strengths (1.9 T).
Topics: Anaerobiosis; Animals; Blood Pressure; Brain; Female; Heart Rate; Hypoxia; Kinetics; Lactates; Lacti | 1984 |
Possible mechanisms for reoxygenation-induced recovery of myocardial high-energy phosphates after hypoxia.
Topics: Adenine Nucleotides; Animals; Creatine Kinase; Energy Metabolism; Female; Heart; Hemodynamics; Hypox | 1983 |
Lactate production in a pure red muscle in absence of anoxia: mechanisms and significance.
Topics: Animals; Dogs; Glycolysis; Hypoxia; In Vitro Techniques; Kinetics; Lactates; Lactic Acid; Mitochondr | 1983 |
[Acid-base equilibrium, blood lactic acid and pyruvic acid in albino rats after muscular exertion under conditions of normal oxygen, hypoxia and hypoxia-hypercapnia].
Topics: Acid-Base Equilibrium; Animals; Hypercapnia; Hypoxia; Lactates; Lactic Acid; Male; Physical Exertion | 1984 |
[Effects of muscular exertion in a hypoxic and hypoxic-hypercapnic respiratory environment on acid-base equilibrium and blood lactic acid in the albino rat raised in hypoxic hypoxia from birth].
Topics: Acid-Base Equilibrium; Animals; Bicarbonates; Hypercapnia; Hypoxia; Lactates; Lactic Acid; Male; Phy | 1984 |
Purine metabolites and lactate as parameters of hypoxia in the newborn infant.
Topics: Asphyxia Neonatorum; Humans; Hypoxanthines; Hypoxia; Infant, Newborn; Lactates; Lactic Acid; Purines | 1984 |
Lactate and regulation of lung glycolytic rate.
Topics: Animals; Glycolysis; Hypoxia; Kinetics; Lactates; Lactic Acid; Lung; Male; Pyruvates; Pyruvic Acid; | 1984 |
Lactate and pyruvate production in isolated thiamine-deficient rat diaphragm strips.
Topics: Animals; Diaphragm; Fatigue; Glucose; Glycolysis; Hydrogen; Hypoxia; In Vitro Techniques; Lactates; | 1984 |
Deleterious effects of oxygen radicals on reoxygenated myocardial cells.
Topics: Animals; Catalase; Coronary Circulation; Creatine Kinase; Energy Metabolism; Free Radicals; Glutathi | 1984 |
Studies on the ability of kidney cells to recover after periods of anoxia.
Topics: Aerobiosis; Animals; Gluconeogenesis; Hypoxia; In Vitro Techniques; Kidney; Kidney Cortex; Kidney Tu | 1984 |
Relation between enzyme release and metabolic changes in reversible anoxic injury of myocardial cells.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Glucose-6-Phosphate; Glucosephosphates; Glutamate | 1984 |
Diffusion-limited gas exchange across amphibian skin.
Topics: Adenosine Triphosphate; Animals; Atmospheric Pressure; Carbon Dioxide; Diffusion; Hypoxia; Lactates; | 1982 |
Influence of age upon the cerebral metabolic changes induced by acute hypoxia on the synaptosomes from dog brain.
Topics: Adenine Nucleotides; Aging; Animals; Dihydroergotoxine; Dogs; Female; Hypoxia; Lactates; Lactic Acid | 1982 |
Effects of hypoxia on blood gas and acid-base parameters of sea bass.
Topics: Acid-Base Equilibrium; Animals; Bicarbonates; Carbon Dioxide; Fishes; Hydrogen-Ion Concentration; Hy | 1982 |
Control of ventilation in running birds: effects of hypoxia, hyperoxia, and CO2.
Topics: Animals; Carbon Dioxide; Chickens; Hypercapnia; Hypoxia; Lactates; Lactic Acid; Oxygen; Physical Exe | 1982 |
Aortic and carotid chemoreceptor responses to metabolic acidosis in the cat.
Topics: Acidosis; Afferent Pathways; Animals; Aorta; Carotid Body; Cats; Chemoreceptor Cells; Female; Hydrog | 1983 |
Effects of extreme hypoxia on the growth and viability of EMT6/SF mouse tumor cells in vitro.
Topics: Animals; Cell Cycle; Cell Survival; Cells, Cultured; DNA Replication; Glucose; Hypoxia; Lactates; La | 1983 |
Effect of postnatal hypoxia on the energy homeostasis of the newborn rat during the early neonatal period.
Topics: Adenine Nucleotides; Alanine; Animals; Animals, Newborn; Blood Glucose; Energy Metabolism; Glucagon; | 1983 |
Hypoxanthine as a test of perinatal hypoxia as compared to lactate, base deficit, and pH.
Topics: Acid-Base Imbalance; Asphyxia Neonatorum; Humans; Hydrogen-Ion Concentration; Hypoxanthine; Hypoxant | 1982 |
The effects of induced hypoxia on the cardiovascular system in dogs poisoned with tetanus toxin.
Topics: Animals; Atropine; Blood Gas Analysis; Dogs; Female; Hemodynamics; Hypoxia; Lactates; Lactic Acid; M | 1982 |
Fetal myocardial oxygen and carbohydrate consumption during acutely induced hypoxemia.
Topics: Animals; Blood Pressure; Coronary Circulation; Female; Fetus; Glucose; Heart; Heart Rate; Hypoxia; L | 1982 |
[Experimental polycythemia induced by lactate in Tritons].
Topics: Animals; Erythrocyte Count; Erythropoiesis; Female; Hypoxia; Lactates; Lactic Acid; Male; Polycythem | 1982 |
Cerebral arterio-venous difference for hypoxanthine and lactate during graded asphyxia in the fetal lamb.
Topics: Animals; Asphyxia; Blood Pressure; Cerebral Arteries; Cerebrovascular Circulation; Evoked Potentials | 1982 |
Role of mitochondrial oxidative phosphorylation in regulation of coronary blood flow.
Topics: Adenosine; Amobarbital; Animals; Calcium; Coronary Circulation; Hypoxanthines; Hypoxia; Inosine; Lac | 1982 |
Liver adenosine triphosphate (ATP) in hypoxia and hemorrhagic shock.
Topics: Acidosis, Respiratory; Adenosine Triphosphate; Animals; Arteries; Hydrogen-Ion Concentration; Hypoxi | 1982 |
Intracellular oxygen supply during hypoxia.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Anaerobiosis; Animals; Cytochromes; Glutathione; Hypo | 1982 |
Plasma ion balance of submerged anoxic turtles at 3 degrees C: the role of calcium lactate formation.
Topics: Animals; Bicarbonates; Calcium; Hypoxia; Immersion; Ions; Lactates; Lactic Acid; Magnesium; Osmolar | 1982 |
Fetal myocardial oxygen and carbohydrate metabolism in sustained hypoxemia in utero.
Topics: Animals; Blood Glucose; Carbohydrate Metabolism; Coronary Vessels; Female; Fetus; Heart; Hypoxia; La | 1982 |
Influence of hypothermia or hyperthermia alone or in combination with pentobarbital or phenytoin on survival time in hypoxic mice.
Topics: Animals; Body Temperature; Brain; Energy Metabolism; Hypothermia, Induced; Hypoxia; Lactates; Lactic | 1981 |
Metabolic changes induced by acute hypoxia on the synaptosomes from dog brain.
Topics: Adenine Nucleotides; Animals; Cerebral Cortex; Dogs; Female; Hypoxia; Lactates; Lactic Acid; Oxygen | 1981 |
Proteolysis in the rat lung: hypoxia and evidence for an inhibitor of proteolysis.
Topics: Adenosine Triphosphate; Animals; Carbon Radioisotopes; Cell-Free System; Cytosol; Hemoglobins; Hypox | 1981 |
Oxygen consumption in rabbit Langendorff hearts perfused with a saline medium.
Topics: Animals; Culture Media; Female; Hypoxia; Lactates; Lactic Acid; Male; Myocardium; Oxygen Consumption | 1981 |
Canine cerebral metabolism and blood flow during hypoxemia and normoxic recovery from hypoxemia.
Topics: Acidosis; Adenine Nucleotides; Animals; Brain; Dogs; Electroencephalography; Glucose; Hypoxia; Lacta | 1981 |
Metabolic alterations accompany ionic disturbances and cellular swelling during a hypoxic insult to the retina: an in vitro study.
Topics: Animals; Blood Glucose; Calcium; Cell Hypoxia; Cell Membrane Permeability; Cell Survival; Culture Te | 1994 |
Cerebral energy metabolism during hypoxaemia. A 31P and 1H magnetic resonance study.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Energy Metabolism; Hemodynamics; Humans; Hydrogen-Io | 1995 |
Effects of energy demand in ischemic and in hypoxemic isolated rat hearts.
Topics: Anaerobiosis; Animals; Energy Metabolism; Glycolysis; Hypoxia; In Vitro Techniques; Lactates; Lactic | 1994 |
Restriction of hypoxic membrane defect by glycine improves mitochondrial and cellular function in reoxygenated renal tubules.
Topics: Acetylglucosaminidase; Animals; Glutamate Dehydrogenase; Glycine; Hypoxia; In Vitro Techniques; Kidn | 1994 |
Prognostic value of hyperlactatemia in neonates.
Topics: Extracorporeal Membrane Oxygenation; Humans; Hypoxia; Infant, Newborn; Lactates; Lactic Acid; Predic | 1995 |
Training in hypoxia vs. training in normoxia in high-altitude natives.
Topics: Adult; Altitude; Bicarbonates; Exercise; Heart Rate; Hemodynamics; Humans; Hypoxia; Lactates; Lactic | 1995 |
Effect of hypoxia on muscle oxygenation and metabolism during arm exercise in humans.
Topics: Adult; Arm; Blood Gas Analysis; Catecholamines; Exercise; Humans; Hypoxia; Lactates; Lactic Acid; Ma | 1995 |
Effect of galactosamine-induced hepatitis on the aerobic and anaerobic metabolism of the rat exposed to high-altitude hypoxia.
Topics: Aerobiosis; Altitude; Anaerobiosis; Animals; Citrate (si)-Synthase; Energy Metabolism; Fatty Acids; | 1995 |
Mechanism of gluconeogenesis inhibition in rat hepatocytes isolated after in vivo hypoxia.
Topics: Adenine Nucleotides; Animals; Cell Separation; Dihydroxyacetone; Gluconeogenesis; Hypoxia; Lactates; | 1995 |
Endocrine responses of fetal sheep to prolonged hypoxemia with and without acidemia: relation to urine production.
Topics: Acids; Animals; Blood Glucose; Blood Pressure; Diuresis; Endocrine Glands; Female; Fetal Blood; Fetu | 1995 |
Stimulation of glycolysis by histidine buffers in mammalian liver during cold hypoxia.
Topics: Adenine Nucleotides; Anaerobiosis; Animals; Buffers; Carnosine; Cold Temperature; Energy Metabolism; | 1995 |
Detection of tissue hypoxia by arteriovenous gradient for PCO2 and pH in anesthetized dogs during progressive hemorrhage.
Topics: Animals; Carbon Dioxide; Dogs; Hemorrhage; Hydrogen-Ion Concentration; Hypoxia; Lactates; Lactic Aci | 1995 |
Muscle energetics in short-term training during hypoxia in elite combination skiers.
Topics: Adult; Altitude; Blood Gas Analysis; Cold Temperature; Humans; Hydrogen-Ion Concentration; Hypoxia; | 1994 |
Modification of the responses of endothelin-1 to exhaustive physical exercise under simulated high-altitude conditions with acute hypoxia.
Topics: Acute Disease; Adult; Altitude; Endothelins; Humans; Hydrocortisone; Hypoxia; Lactates; Lactic Acid; | 1995 |
Immediate responses of endothelial cells to hypoxia and reoxygenation: an in vitro model of cellular dysfunction.
Topics: Animals; Arachidonic Acid; Cattle; Cell Count; Cells, Cultured; Endothelium, Vascular; Epoprostenol; | 1995 |
Oxygen, glucose, and lactate uptake by fetus and placenta during prolonged hypoxemia.
Topics: Animals; Arteries; Female; Fetal Blood; Fetus; Gases; Glucose; Hydrogen-Ion Concentration; Hypoxia; | 1995 |
Blood lactate and acid-base balance in graded neonatal hypoxia: evidence for oxygen-restricted metabolism.
Topics: Acid-Base Equilibrium; Acidosis; Anaerobic Threshold; Analysis of Variance; Animals; Animals, Newbor | 1994 |
Comparison of effects of aprikalim and of hypoxic and ischaemic preconditioning on extracellular potassium accumulation, metabolism, and functional recovery of the globally ischaemic rat heart.
Topics: Animals; Antihypertensive Agents; Basal Metabolism; Extracellular Space; Heart; Hypoxia; Lactates; L | 1994 |
Protection of atrial function in hypoxia by high potassium concentration.
Topics: Adenine Nucleotides; Animals; Cardiac Pacing, Artificial; Diastole; Energy Metabolism; Evaluation St | 1994 |
Hydroxymalonate inhibits lactate uptake by the rabbit hindlimb.
Topics: Animals; Blood Gas Analysis; Blood Glucose; Cardiac Output; Electric Stimulation; Female; Hindlimb; | 1994 |
Plasma lactate concentration as a predictor of death in neonates with severe hypoxemia requiring extracorporeal membrane oxygenation.
Topics: Biomarkers; Case-Control Studies; Extracorporeal Membrane Oxygenation; Hemodynamics; Humans; Hypoxia | 1994 |
Effect of lactic and CO2 acidosis on neuronal function following glucose-oxygen deprivation in rat hippocampal slices.
Topics: Acidosis, Lactic; Acidosis, Respiratory; Animals; Carbon Dioxide; Female; Glucose; Hippocampus; Hydr | 1994 |
Neuropeptide Y release from human heart is enhanced during prolonged exercise in hypoxia.
Topics: Adult; Carbon Dioxide; Cardiac Output; Coronary Circulation; Exercise; Exercise Test; Heart Rate; Hu | 1994 |
Effect of hypoxia and hyperoxia on human +Gz duration tolerance.
Topics: Acceleration; Adult; Aerobiosis; Anaerobiosis; Electroencephalography; Gravitation; Gravity Suits; H | 1994 |
Bronchial smooth muscle energetics: effect of iodoacetate and hypoxia.
Topics: Animals; Bronchi; Carbachol; Cattle; Energy Metabolism; Hypoxia; In Vitro Techniques; Iodoacetates; | 1994 |
Superresistance against hypoxia after preliminary adaptation to repeated stress.
Topics: Acid-Base Equilibrium; Adaptation, Physiological; Animals; Blood Gas Analysis; Fatty Acids, Nonester | 1994 |
Metabolic recovery of isolated working rat heart after brief global ischemia.
Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Animals; Fasting; Glucose-6-Phosphate; Glucosephospha | 1994 |
[Effects of fructose on left ventricular function during hypoxia].
Topics: Acidosis, Lactic; Anesthesia; Animals; Blood Glucose; Dogs; Fructose; Hypoxia; Lactates; Lactic Acid | 1994 |
Ipsilateral and contralateral testicular biochemical acute changes after unilateral testicular torsion and detorsion.
Topics: Animals; Hypoxanthine; Hypoxanthines; Hypoxia; Lactates; Lactic Acid; Lipid Peroxidation; Male; Rats | 1994 |
Increased oxygen affinity contributes to tissue hypoxia in critically ill patients with low oxygen delivery.
Topics: Biological Transport, Active; Critical Illness; Humans; Hypoxia; Lactates; Lactic Acid; Multiple Org | 1994 |
Cerebral energy metabolism in fetal guinea pigs during moderate maternal hypoxemia at 0.75 of gestation.
Topics: Animals; Brain; Embryonic and Fetal Development; Energy Metabolism; Fetus; Glycolysis; Guinea Pigs; | 1993 |
Cerebral glucose and energy utilization during the evolution of hypoxic-ischemic brain damage in the immature rat.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Animals, Newborn; Brain; Brain Ischemia; Energy Metab | 1994 |
Myocardial lactate release during prolonged exercise under hypoxaemia.
Topics: Adult; Exercise; Humans; Hypoxia; Lactates; Lactic Acid; Male; Myocardium; Oxygen; Time Factors | 1993 |
Cerebral metabolism during sustained hypoxemia in preterm fetal sheep.
Topics: Animals; Brain; Cerebrovascular Circulation; Fetal Hypoxia; Fetus; Gestational Age; Glucose; Hypoxia | 1994 |
Relationship between intracellular pH and metabolite concentrations during metabolic inhibition in isolated ferret heart.
Topics: Acidosis; Adenosine Triphosphate; Animals; Cyanides; Ferrets; Glycolysis; Heart; Hydrogen-Ion Concen | 1993 |
Fatigue and exhaustion in chronic hypobaric hypoxia: influence of exercising muscle mass.
Topics: Adult; Altitude; Chronic Disease; Electromyography; Fatigue; Forearm; Humans; Hypoxia; Lactates; Lac | 1994 |
Recovery of the ovine fetus from sustained hypoxia: effects on endocrine, cardiovascular, and biophysical activity.
Topics: Animals; Blood Glucose; Carbon Dioxide; Cardiovascular System; Electrophysiology; Endocrine Glands; | 1994 |
The effects of twenty-four hours of reduced uterine blood flow on fetal fluid balance in sheep.
Topics: Amniotic Fluid; Animals; Deglutition; Diuresis; Electrolytes; Female; Fetal Blood; Fetal Diseases; F | 1994 |
Swallowing and urine flow responses of ovine fetuses to 24 h of hypoxia.
Topics: Animals; Blood Glucose; Body Fluids; Circadian Rhythm; Deglutition; Diuresis; Electrolytes; Female; | 1994 |
Interstitial purine metabolites and lactate during regional myocardial hypoxia.
Topics: Adenosine; Animals; Cardiomyopathies; Coronary Circulation; Dialysis; Dogs; Extracellular Space; Fem | 1993 |
Net uptake of lactate by rabbit hindlimb during hypoxia.
Topics: Animals; Blood Glucose; Blood Pressure; Cardiac Output; Female; Glucose; Hemoglobins; Hindlimb; Hydr | 1993 |
Influence of stimulation parameters on the release of adenosine, lactate and CO2 from contracting dog gracilis muscle.
Topics: Adenosine; Animals; Blood Gas Analysis; Carbon Dioxide; Dogs; Electric Stimulation; Hemodynamics; Hy | 1993 |
Fluorocarbon simulation of myocardial ischaemia and reperfusion: studies of relationships between force and intracellular calcium.
Topics: Animals; Calcium; Calcium-Transporting ATPases; Ferrets; Fluorocarbons; Hypoxia; Intracellular Fluid | 1993 |
Dynamics of myocardial lactate efflux after a step in heart rate in isolated rabbit hearts.
Topics: Animals; Female; Glucose; Heart Rate; Hypoxia; In Vitro Techniques; Lactates; Lactic Acid; Male; Myo | 1993 |
Interaction between temperature and hypoxia in the alligator.
Topics: Alligators and Crocodiles; Animals; Body Temperature; Hydrogen-Ion Concentration; Hyperventilation; | 1993 |
Hypoxia selectively excites vasomotor neurons of rostral ventrolateral medulla in rats.
Topics: Animals; Arteries; Bicarbonates; Chemoreceptor Cells; Denervation; Hydrogen; Hypoxia; Iontophoresis; | 1994 |
Effects of training in normoxia and normobaric hypoxia on human muscle ultrastructure.
Topics: Adult; Atmospheric Pressure; Bicycling; Humans; Hypoxia; Lactates; Lactic Acid; Male; Mitochondria, | 1993 |
Myocardial oxygen supply and lactate metabolism during marked arterial hypoxaemia.
Topics: Adenosine Triphosphate; Adult; Arteries; Carbon Dioxide; Coronary Circulation; Humans; Hypoxia; Lact | 1993 |
Interstitial lactate and glucose concentrations of the isolated perfused rat heart before, during and after anoxia.
Topics: Animals; Capillary Permeability; Coronary Circulation; Extracellular Space; Female; Glucose; Heart; | 1993 |
Hypoxic preconditioning attenuates stunning caused by repeated coronary artery occlusions in dog heart.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Disease; Dogs; Female; Hypoxia; Lact | 1993 |
The effect of normocapnic hypoxia and the duration of exposure to hypoxia on supramaximal exercise performance.
Topics: Adult; Alkalosis; Anaerobiosis; Bicycling; Blood Gas Analysis; Carbon Dioxide; Exercise; Exercise Te | 1993 |
Comparative effects of ischemia and hypoxemia on left ventricular systolic and diastolic function in humans.
Topics: Adult; Aged; Coronary Circulation; Diastole; Female; Humans; Hydrogen; Hypoxia; Lactates; Lactic Aci | 1993 |
Oxygen extraction is altered by endotoxin during tamponade-induced stagnant hypoxia in the dog.
Topics: Animals; Blood Pressure; Cardiac Tamponade; Dogs; Endotoxins; Hypoxia; Lactates; Lactic Acid; Oxygen | 1993 |
Adenosine effect on lactate and pyruvate production in the hypoxic guinea pig heart.
Topics: Adenosine; Animals; Guinea Pigs; Heart; Hypoxia; In Vitro Techniques; Lactates; Lactic Acid; Myocard | 1993 |
[Left ventricular function during hypoxia--II: Effects of intramyocardial pH].
Topics: Animals; Dogs; Glucose; Hydrogen-Ion Concentration; Hypoxia; Lactates; Lactic Acid; Myocardium; Vent | 1993 |
Effect of sepsis on brain energy metabolism in normoxic and hypoxic rats.
Topics: Animals; Brain; Energy Metabolism; Female; Hypoxia; Lactates; Lactic Acid; Magnetic Resonance Spectr | 1993 |
Severe hypoxia decreases oxygen uptake relative to intensity during submaximal graded exercise.
Topics: Adult; Exercise; Humans; Hypoxia; Lactates; Lactic Acid; Male; Oxygen Consumption | 1993 |
Effects of indomethacin on brain blood flow and cerebral metabolism in hypoxic newborn piglets.
Topics: Animals; Animals, Newborn; Arteries; Brain; Cerebrovascular Circulation; Dose-Response Relationship, | 1993 |
Fetal pH improvement after 24 h of severe, nonlethal hypoxia.
Topics: Animals; Bicarbonates; Fetal Blood; Hindlimb; Hydrogen-Ion Concentration; Hypoxia; Lactates; Lactic | 1993 |
Effect of acute hypoxia on metabolism and ventilation in awake piglets.
Topics: Animals; Carbon Dioxide; Hypoxia; Lactates; Lactic Acid; Oxygen; Oxygen Consumption; Pyruvates; Pyru | 1993 |
Mechanisms of reoxygenation-induced calcium overload in cardiac myocytes: dependence on pHi.
Topics: Acids; Animals; Animals, Newborn; Calcium; Cells, Cultured; Hydrogen-Ion Concentration; Hypoxia; Lac | 1995 |
Blood pressure and cardiovascular reflex development in fetal sheep. Relation to hypoxaemia, weight, and blood glucose.
Topics: Animals; Baroreflex; Blood Glucose; Blood Pressure; Body Weight; Cardiovascular Physiological Phenom | 1995 |
Phosphate excretion during 24 h of hypoxia in conscious rats.
Topics: Animals; Blood Gas Analysis; Consciousness; Cyclic AMP; Homeostasis; Hydrocortisone; Hypoxia; Lactat | 1995 |
The role of accumulation of sodium and calcium on contractile failure of the hypoxic/reoxygenated heart.
Topics: Adenosine Triphosphate; Animals; Calcium; Cell Membrane Permeability; Energy Metabolism; Hypoxia; In | 1996 |
Plasma lactate as a predictor of early childhood neurodevelopmental outcome of neonates with severe hypoxaemia requiring extracorporeal membrane oxygenation.
Topics: Biomarkers; Developmental Disabilities; Extracorporeal Membrane Oxygenation; Humans; Hypoxia; Infant | 1996 |
Circulatory effects of hypoxia, acute normovolemic hemodilution, and their combination in anesthetized pigs.
Topics: Anesthesia; Animals; Coronary Circulation; Hematocrit; Hemodilution; Hypoxia; Lactates; Lactic Acid; | 1996 |
Alkali therapy extends the period of survival during hypoxia: studies in rats.
Topics: Acidosis, Lactic; Adenosine Triphosphate; Alkalies; Anaerobiosis; Animals; Glycolysis; Hypoxia; Lact | 1996 |
Lactate distribution and metabolism during and after anoxia in the turtle, Chrysemys picta bellii.
Topics: Animals; Carbon Dioxide; Carbon Radioisotopes; Extracellular Space; Glycogen; Hypoxia; Lactic Acid; | 1996 |
Gluconeogenesis during hypoxia in vascular smooth muscle studied by 13C-NMR.
Topics: Animals; Carotid Arteries; Fructosediphosphates; Gluconeogenesis; Glucose; Glycolysis; Hypoxia; In V | 1995 |
Comparison of gastric intramucosal pH measurements with oxygen supply, oxygen consumption and arterial lactate in patients with severe sepsis.
Topics: Adolescent; Adult; Aged; Gastric Mucosa; Humans; Hydrogen-Ion Concentration; Hypoxia; Lactic Acid; M | 1996 |
Effects of hypoxia on urinary organic acid and hypoxanthine excretion in fetal sheep.
Topics: Animals; Asphyxia Neonatorum; Blood Gas Analysis; Blood Pressure; Carboxylic Acids; Disease Models, | 1996 |
Endogenous adenosine increases O2 utilisation efficiency in isoprenaline-stimulated canine myocardium.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adrenergic beta-Agonists; Animals; Dogs; Hypoxia; Isoproter | 1996 |
Effect of acute normobaric hypoxia on quadriceps integrated electromyogram and blood metabolites during incremental exercise to exhaustion.
Topics: Adult; Ammonia; Arteries; Atmospheric Pressure; Electromyography; Heart Rate; Humans; Hypoxia; Lacti | 1996 |
Glycolysis is not responsible for the tolerance of immature renal tubules to anoxia.
Topics: Adenosine Triphosphate; Anaerobiosis; Animals; Evaluation Studies as Topic; Glycolysis; Hypoxia; Kid | 1996 |
Relationship between anoxia exposure and antioxidant status in the frog Rana pipiens.
Topics: Animals; Antioxidants; Glutathione; Hypoxia; Lactic Acid; Lipid Peroxides; Liver; Oxidoreductases; R | 1996 |
Lactate accumulation during moderate hypoxic hypoxia in neocortical rat brain.
Topics: Animals; Aspartic Acid; Brain; Energy Metabolism; Female; Hypoxia; Lactic Acid; Rats; Rats, Sprague- | 1996 |
Kinetics of oxygen consumption during maximal exercise at different muscle temperatures.
Topics: Adult; Blood Flow Velocity; Cold Temperature; Humans; Hypoxia; Immersion; Kinetics; Lactic Acid; Mal | 1995 |
Maximal accumulated oxygen deficit of resistance-trained men.
Topics: Adult; Anaerobic Threshold; Anaerobiosis; Blood Gas Analysis; Body Mass Index; Exercise; Humans; Hyd | 1996 |
Transport and metabolism of L-glutamate during oxygenation, anoxia, and reoxygenation of rat cardiac myocytes.
Topics: Amino Acids; Animals; Biological Transport; Energy Metabolism; Glutamic Acid; Heart; Hypoxia; Intrac | 1996 |
Tissue hypoxia in ipsilateral and contralateral testes undergoing surgically induced maldescent.
Topics: Animals; Animals, Newborn; Cryptorchidism; Hypoxanthine; Hypoxia; Lactic Acid; Male; Rats; Testis | 1996 |
New aspects of lactate metabolism: IGF-I and insulin regulate mitochondrial function in cultured brain cells during normoxia and hypoxia.
Topics: Animals; Astrocytes; Brain; Cells, Cultured; Glucose; Hypoxia; Insulin; Insulin-Like Growth Factor I | 1996 |
Astrocyte glucose metabolism under normal and pathological conditions in vitro.
Topics: Acidosis; Adenosine Triphosphate; Animals; Astrocytes; Azides; Deoxyglucose; Drug Synergism; Glucose | 1996 |
Dynamics of myocardial adaptation to low-flow ischemia and hypoxemia.
Topics: Adaptation, Physiological; Animals; Coronary Circulation; Heart; Hypoxia; In Vitro Techniques; Lacti | 1996 |
Myocardial anaerobic metabolism occurs at a critical coronary venous PO2 in pigs.
Topics: Anaerobiosis; Animals; Cardiac Output; Coronary Circulation; Coronary Vessels; Hypoxia; Lactic Acid; | 1997 |
Effect of hypoxia and carbon monoxide on muscle oxygenation during exercise.
Topics: Adult; Carbon Monoxide; Carboxyhemoglobin; Humans; Hypoxia; Lactic Acid; Male; Muscle, Skeletal; Oxy | 1997 |
Intracellular lactate controls adenosine output from dog gracilis muscle during moderate systemic hypoxia.
Topics: Adenosine; Animals; Dogs; Gases; Hemodynamics; Hindlimb; Hydrogen-Ion Concentration; Hypoxia; Intrac | 1997 |
Effect of hypoxemia on tissue glycogen content and glycolytic enzyme activities in fetal sheep.
Topics: Animals; Blood Glucose; Cyclic AMP; Fetal Blood; Fetus; Gases; Glucose-6-Phosphatase; Glycogen; Glyc | 1997 |
The effect of exercise on the development of respiratory depression during sustained isocapnic hypoxia in humans.
Topics: Adult; Carbon Dioxide; Chemoreceptor Cells; Exercise; Humans; Hypoxia; Lactic Acid; Male; Oxygen; Re | 1997 |
The effects of propofol on cerebral high energy metabolites, lactate, and glucose in normoxic and severely hypoxic rats.
Topics: Adenine Nucleotides; Anesthetics, Intravenous; Animals; Cerebral Cortex; Energy Metabolism; Glucose; | 1997 |
Balancing hypoxia and hypothermia in cold-submerged frogs.
Topics: Acid-Base Equilibrium; Aerobiosis; Animals; Behavior, Animal; Cold Temperature; Hydrogen-Ion Concent | 1997 |
Chronic hypoxia, glutathione-dependent detoxication, and metabolic instability in rat small intestine.
Topics: Animals; Cell Survival; Chronic Disease; Fructose; Glutathione; Hypoxia; Ileum; Inactivation, Metabo | 1997 |
1996 J.B. Wolffe Memorial Lecture. Challenging beliefs: ex Africa semper aliquid novi.
Topics: Anaerobiosis; Dietary Carbohydrates; Exercise; Humans; Hypoxia; Lactic Acid; Mitochondria, Muscle; M | 1997 |
Energy turnover in the normoxic and anoxic turtle heart.
Topics: Adenosine Triphosphate; Anaerobic Threshold; Animals; Energy Metabolism; Glycolysis; Hypoxia; Lactic | 1997 |
On the cardioprotective effect of adenosine.
Topics: Adenosine; Adenosine Triphosphate; Animals; Glycogen; Guinea Pigs; Heart; Hypoxia; In Vitro Techniqu | 1996 |
[Effect of a three month training period on the maximal oxygen deficiency in high level performance sprinters].
Topics: Adult; Anaerobic Threshold; Blood Gas Analysis; Humans; Hypoxia; Lactic Acid; Oxygen; Oxygen Consump | 1997 |
Energy metabolism in liver of anoxia-tolerant turtle species (Pseudemys scripta): a model for studying hepatic tolerance to cold hypoxia.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Biomarkers; Cold Te | 1997 |
Carnitine palmitoyl-transferase enzyme inhibition protects proximal tubules during hypoxia.
Topics: Acylation; Adenosine Triphosphate; Animals; Carnitine; Carnitine O-Palmitoyltransferase; Carrier Pro | 1997 |
Myocardial adaptation to acute oxygen shortage. A kinetic analysis.
Topics: Adaptation, Physiological; Adenosine Triphosphate; Animals; Energy Metabolism; Glycogen; Hypoxia; In | 1997 |
Release of lactate by the lung in acute lung injury.
Topics: Biological Transport, Active; Case-Control Studies; Critical Illness; Humans; Hypoxia; Lactic Acid; | 1997 |
Effects of hemodilution and oxygen breathing on gut oxygenation in anesthetized dogs.
Topics: Anesthesia; Animals; Cardiac Output; Digestive System; Dogs; Hematocrit; Hemodilution; Hypoxia; Inte | 1997 |
The effects of low pH and CO2 on bovine corneal lactate production.
Topics: Acidosis; Animals; Carbon Dioxide; Cattle; Cornea; Hydrogen-Ion Concentration; Hypoxia; Lactic Acid; | 1997 |
Mixed venous oxygen saturation and biochemical parameters of hypoxia during progressive hypoxemia in 10- to 14-day-old piglets.
Topics: Animals; Disease Progression; Hypoxia; Lactic Acid; Linear Models; Oxygen; Pyruvic Acid; Swine; Vein | 1997 |
Glia are the main source of lactate utilized by neurons for recovery of function posthypoxia.
Topics: Animals; Citrates; Electrophysiology; Hippocampus; Hypoxia; In Vitro Techniques; Lactic Acid; Male; | 1997 |
Effects of indomethacin and polyunsaturated fatty acid diet on exercise-induced hypoxaemia in master athletes.
Topics: Adult; Cyclooxygenase Inhibitors; Dietary Fats, Unsaturated; Exercise; Fatty Acids, Unsaturated; Hum | 1998 |
Lactate-induced vascular relaxation in porcine coronary arteries is mediated by Ca2+-activated K+ channels.
Topics: Animals; Calcium; Coronary Vessels; Hydrogen-Ion Concentration; Hypoxia; In Vitro Techniques; Lactic | 1998 |
Low concentrations of adenosine receptor blocker decrease protection by hypoxic preconditioning in ischemic rat hearts.
Topics: Adenosine; Adenosine Triphosphate; Animals; Creatine Kinase; Hypoxia; In Vitro Techniques; Ischemic | 1998 |
Metabolism and acid-base status during hypoxic ventilatory depression.
Topics: Acid-Base Equilibrium; Analysis of Variance; Animals; Carbon Dioxide; Hypoxia; Lactic Acid; Male; Ox | 1997 |
Cardioprotective profile of MET-88, an inhibitor of carnitine synthesis, and insulin during hypoxia in isolated perfused rat hearts.
Topics: Administration, Oral; Animals; Cardiovascular Agents; Carnitine; Coronary Circulation; Glucose; Glyc | 1998 |
Effect of hyperglycemia on brain cell membrane function and energy metabolism during hypoxia-ischemia in newborn piglets.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Brain; Brain Ischemia; Cell Membrane; Energy Meta | 1998 |
Asanguineous isolated hyperthermic perfusion of the liver: results of an experimental study in pigs.
Topics: Animals; Hyperthermia, Induced; Hypoxia; Lactic Acid; Liver; Perfusion; Survival Rate; Swine; Transa | 1998 |
Restoration of hypoxia-stimulated glucose uptake in GLUT4-deficient muscles by muscle-specific GLUT4 transgenic complementation.
Topics: Adenosine Triphosphate; Animals; Deoxyglucose; Female; Genetic Complementation Test; Glucose Transpo | 1998 |
Transcapillary transport of metaiodobenzylguanidine (MIBG) in isolated rat heart.
Topics: 3-Iodobenzylguanidine; Animals; Blood Pressure; Capillary Permeability; Coronary Circulation; Female | 1998 |
Reductions in cardiac output in hypoxic young pigs: systemic and regional perfusion and oxygen metabolism.
Topics: Animals; Blood Glucose; Brain Chemistry; Cardiac Output; Glucose; Heart Rate; Hematocrit; Hemodynami | 1998 |
Lactate and pyruvate changes in the cerebral gray and white matter during posthypoxic seizures in newborn pigs.
Topics: Animals; Animals, Newborn; Cerebellum; Electroencephalography; Hypoxia; Lactic Acid; Microdialysis; | 1998 |
Proton MR spectroscopy in infants with cerebral energy deficiency due to hypoxia and metabolic disorders.
Topics: Aspartic Acid; Basal Ganglia; Brain; Brain Diseases, Metabolic; Child, Preschool; Follow-Up Studies; | 1998 |
Unloaded skeletal muscle O2 uptake decreases with decreased venous PO2 at high-frequency stimulation.
Topics: Animals; Diffusion; Dogs; Electric Stimulation; Hypoxia; Lactic Acid; Muscle Contraction; Muscle, Sk | 1998 |
Effects of hypothermic hypoxia on anaerobic energy metabolism in isolated anuran livers.
Topics: Adenine Nucleotides; Anaerobiosis; Animals; Body Water; Energy Metabolism; Glucose; Hypothermia; Hyp | 1998 |
Affected enzyme activities in Alzheimer's disease are sensitive to antemortem hypoxia.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Brain; Cadaver; Female; Humans; Hypoxia; L | 1998 |
Influence of glutathione peroxidase on coronary artery responses to alterations in PO2 and H2O2.
Topics: Animals; Arteries; Catalase; Cattle; Coronary Vessels; Endothelium, Vascular; Glutathione Peroxidase | 1999 |
Subzero nonfreezing storage of isolated rat hepatocytes in University of Wisconsin solution.
Topics: Adenosine; Adenosine Triphosphate; Allopurinol; Animals; Cell Separation; Cryopreservation; Glutathi | 1999 |
Arterial O2 content and tension in regulation of cardiac output and leg blood flow during exercise in humans.
Topics: Adult; Anemia; Arteries; Cardiac Output; Epinephrine; Exercise; Humans; Hypoxia; Lactic Acid; Leg; M | 1999 |
Localised proton magnetic resonance spectroscopy of the brain after perinatal hypoxia: a preliminary report.
Topics: Aspartic Acid; Asphyxia; Brain; Choline; Creatine; Follow-Up Studies; Humans; Hypoxia; Infant, Newbo | 1999 |
[Lactate: a marker for tissue hypoxia].
Topics: Biomarkers; Humans; Hypoxia; Lactic Acid | 1999 |
Tissue oxygenation by near-infrared spectroscopy and muscle blood flow during isometric contractions of the forearm.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Carbon Dioxide; Electromyography; Female; Forearm; Heart | 1999 |
Effect of reduced inspired oxygen on fetal growth and maternal glucose metabolism in rat pregnancy.
Topics: Animals; Blood Glucose; Embryonic and Fetal Development; Female; Fetus; Glucose Transporter Type 1; | 1999 |
Leukocyte glycolysis and lactate output in animal sepsis and ex vivo human blood.
Topics: Animals; Biomarkers; Blood Platelets; Critical Illness; Erythrocytes; Female; Glycolysis; Humans; Hy | 1999 |
Effect of diazepam on survival of the immature pig in a confined atmosphere.
Topics: Animals; Atmosphere Exposure Chambers; Blood Gas Analysis; Blood Pressure; Body Temperature; Diazepa | 1999 |
Anemic hypoxia in moderate intracerebral hemorrhage: the alterations of cerebral hemodynamics and brain metabolism.
Topics: Anemia; Animals; Arteries; Blood Flow Velocity; Blood Pressure; Brain; Cerebral Hemorrhage; Cerebrov | 1999 |
Erythropoietin concentration and arterial haemoglobin saturation with supramaximal exercise.
Topics: Adult; Erythropoietin; Exercise; Exercise Test; Humans; Hypoxia; Lactic Acid; Male; Oximetry; Oxygen | 1999 |
Effects of intraalveolar oxygen concentration on alveolar fluid absorption and metabolism in isolated rat lungs.
Topics: Adenosine Triphosphate; Animals; Bronchoalveolar Lavage Fluid; Energy Metabolism; Glucose; Glycolysi | 1999 |
Lactate attenuates neuron specific enolase elevation in newborn rats.
Topics: Adenosine Triphosphate; Animals; Biomarkers; Brain; Brain Diseases; Hypoxia; Lactic Acid; Phosphopyr | 1999 |
The use of extracellular lactate as an oxidative substrate in the oxygen-limited frog.
Topics: Acid-Base Equilibrium; Animals; Extracellular Space; Hydrogen-Ion Concentration; Hypoxia; In Vitro T | 1999 |
Ethanol attenuates lactate production in hypoxic postnatal day 4 rat cerebella.
Topics: Age Factors; Animals; Animals, Newborn; Central Nervous System Depressants; Cerebellum; Ethanol; Hyp | 1999 |
Relationship between mixed venous oxygen saturation and markers of tissue oxygenation in progressive hypoxic hypoxia and in isovolemic anemic hypoxia in 8- to 12-day-old piglets.
Topics: Anemia; Animals; Animals, Newborn; Hemoglobins; Hypoxia; Lactic Acid; Oximetry; Oxygen; Oxygen Consu | 1999 |
Extracellular lactate and glucose alterations in the brain after head injury measured by microdialysis.
Topics: Adult; Analysis of Variance; Brain Injuries; Cerebral Cortex; Cerebrovascular Circulation; Female; G | 1999 |
Modulation of systemic hemodynamics by exogenous L-arginine in normal and bacteremic sheep.
Topics: Acidosis; Animals; Arginine; Bacteremia; Blood Gas Analysis; Blood Pressure; Disease Models, Animal; | 1999 |
[Lactate: a marker for tissue hypoxia].
Topics: Humans; Hypoxia; Lactic Acid | 1999 |
Monitoring by subcutaneous microdialysis in neurosurgical intensive care.
Topics: Adolescent; Aged; Blood Glucose; Brain Injuries; Chromatography, High Pressure Liquid; Female; Gluta | 1999 |
Hypothermia abolishes hypoxia-induced hyperpermeability in brain microvessel endothelial cells.
Topics: Adenosine Triphosphate; Animals; Brain; Cell Membrane Permeability; Cells, Cultured; Cold Temperatur | 1999 |
Expression of heat shock proteins in turtle and mammal hearts: relationship to anoxia tolerance.
Topics: Air; Animals; Female; Heat-Shock Proteins; Hypoxia; Lactic Acid; Male; Rabbits; Rats; Rats, Sprague- | 2000 |
What governs skeletal muscle VO2max? New evidence.
Topics: Anaerobic Threshold; Analysis of Variance; Animals; Diffusion; Disease Models, Animal; Dogs; Exercis | 2000 |
Effects of RGP lens extended wear on glucose-lactate metabolism and stromal swelling in the rabbit cornea.
Topics: Adenosine Triphosphate; Animals; Aqueous Humor; Biomarkers; Contact Lenses, Extended-Wear; Corneal E | 2000 |
Redox pairs, tissue hypoxia, organ dysfunction, and mortality.
Topics: Humans; Hypoxia; Ketone Bodies; Lactic Acid; Multiple Organ Failure; Oxidation-Reduction; Predictive | 2000 |
Regulation of glycogen phosphorylase and PDH during exercise in human skeletal muscle during hypoxia.
Topics: Adenosine Triphosphate; Adult; Carnitine; Coenzyme A; Energy Metabolism; Exercise; Glycogen; Glycoly | 2000 |
Hepatic and splanchnic oxygen consumption during acute hypoxemic hypoxia in anesthetized pigs.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Female; Hemodynamics; Hypoxia; Lactic Acid; L | 2000 |
Age-dependent metabolic effects of repeated hypoxemia in piglets.
Topics: Aging; Animals; Behavior, Animal; Carbon Dioxide; Catecholamines; Hemodynamics; Hypoxia; Lactic Acid | 2000 |
Acute oxygen supplementation restores markers of hepatocyte energy status and hypoxia in cirrhotic rats.
Topics: Animals; Biomarkers; Blood Gas Analysis; Carbon Tetrachloride Poisoning; Energy Metabolism; Hypoxia; | 2000 |
Oxygen deficit is related to the exercise time to exhaustion at maximal aerobic speed in middle distance runners.
Topics: Adult; Exercise; Humans; Hydrogen-Ion Concentration; Hypoxia; Lactic Acid; Male; Oxygen; Respiration | 1999 |
Effects of hypoxia on plasma amino acids of fetal sheep.
Topics: Amino Acids; Animals; Blood Glucose; Chromatography, Ion Exchange; Female; Hydrogen-Ion Concentratio | 2000 |
Bone and shell contribution to lactic acid buffering of submerged turtles Chrysemys picta bellii at 3 degrees C.
Topics: Acid-Base Equilibrium; Adaptation, Physiological; Animals; Body Weight; Bone and Bones; Buffers; Cal | 2000 |
Performance level and cardiopulmonary responses during a cycle-run trial.
Topics: Adult; Analysis of Variance; Bicycling; Competitive Behavior; Exercise Test; Humans; Hypoxia; Lactic | 2000 |
Operation Everest III: role of plasma volume expansion on VO(2)(max) during prolonged high-altitude exposure.
Topics: Adult; Altitude; Altitude Sickness; Atmosphere Exposure Chambers; Body Mass Index; Heart Rate; Human | 2000 |
Time-pattern of lactate and lactate to pyruvate ratio in the first 24 hours of intensive care emergency admissions.
Topics: Acidosis, Lactic; APACHE; Biomarkers; Critical Care; Emergencies; Female; Finland; Glasgow Coma Scal | 2000 |
Anoxia tolerance of con-familial tiger beetle larvae is associated with differences in energy flow and anaerobiosis.
Topics: Adaptation, Physiological; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; A | 2000 |
Osmolar gap metabolic acidosis in a 60-year-old man treated for hypoxemic respiratory failure.
Topics: Acidosis, Lactic; Drug Combinations; Humans; Hypnotics and Sedatives; Hypoxia; Infusions, Intravenou | 2000 |
Interleukin-1beta alters the oxygen delivery-oxygen consumption relationship in rabbits by increasing the slope of the supply-independent line.
Topics: Animals; Cardiac Tamponade; Female; Humans; Hypotension; Hypoxia; Interleukin-1; Lactic Acid; Models | 2000 |
Effect of severe normocapnic hypoxia on renal function in growth-restricted newborn piglets.
Topics: Acidosis; Animals; Animals, Newborn; Blood Gas Analysis; Blood Glucose; Blood Pressure; Carbon Dioxi | 2000 |
Oxygen consumption, blood lactate and inter-individual variation in the gulf killifish, Fundulus grandis, during hypoxia and recovery.
Topics: Animals; Hypoxia; Killifishes; Lactic Acid; Oxygen Consumption | 2000 |
Metabolic effects induced by epinephrine in Rana balcanica erythrocytes under normoxic and hypoxic conditions.
Topics: Adenosine Triphosphate; Adrenergic Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonis | 2000 |
Dynamic changes in glucose and lactate in the cortex of the freely moving rat monitored using microdialysis.
Topics: Adrenergic beta-Antagonists; Animals; Atmosphere Exposure Chambers; Cerebral Cortex; Extracellular S | 2000 |
Conservation of phosphorylation state of cardiac phosphofructokinase during in vitro hypothermic hypoxia.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Alkanesulfonic Acids; Animal | 2000 |
Increased skin lactate in complex regional pain syndrome: evidence for tissue hypoxia?
Topics: Adult; Female; Humans; Hypoxia; Lactic Acid; Male; Microdialysis; Middle Aged; Reflex Sympathetic Dy | 2000 |
Respiratory compensation point during incremental exercise as related to hypoxic ventilatory chemosensitivity and lactate increase in man.
Topics: Acidosis, Lactic; Adult; Carbon Dioxide; Carotid Body; Female; Humans; Hypercapnia; Hypoxia; Lactic | 2000 |
The physiology of hibernation among painted turtles: the midland painted turtle (Chrysemys picta marginata).
Topics: Acid-Base Equilibrium; Acidosis; Animals; Calcium; Diving; Hematocrit; Hibernation; Hypoxia; Lactic | 2001 |
Metabolic component of intestinal PCO(2) during dysoxia.
Topics: Acid-Base Equilibrium; Animals; Carbon Dioxide; Hypoxia; In Vitro Techniques; Intestinal Mucosa; Kin | 2000 |
Osteoblast expression of vascular endothelial growth factor is modulated by the extracellular microenvironment.
Topics: Acidosis, Lactic; Animals; Animals, Newborn; Cells, Cultured; Endothelial Growth Factors; Extracellu | 2001 |
Purinergic contribution to circulatory, metabolic, and adrenergic responses to acute hypoxemia in fetal sheep.
Topics: Animals; Blood Glucose; Blood Pressure; Catecholamines; Epinephrine; Female; Femoral Artery; Fetal B | 2001 |
Effect of NaHCO3 on cardiac energy metabolism and contractile function during hypoxemia.
Topics: Acidosis, Lactic; Analysis of Variance; Animals; Blood Gas Analysis; Disease Models, Animal; Dogs; D | 2001 |
Carboxyhemoglobin and lactate levels do not correlate in critically ill patients.
Topics: Animals; Biomarkers; Blood Gas Analysis; Carboxyhemoglobin; Critical Illness; Disease Models, Animal | 1999 |
Effect of prior high-intensity exercise on exercise-induced arterial hypoxemia in Thoroughbred horses.
Topics: Animals; Arteries; Bicarbonates; Blood Gas Analysis; Blood-Air Barrier; Body Temperature; Endoscopy; | 2001 |
Diaphragm fatigue during exercise at high altitude: the role of hypoxia and workload.
Topics: Adult; Altitude; Diaphragm; Exercise; Humans; Hypoxia; Lactic Acid; Male; Muscle Fatigue; Workload | 2001 |
Physiological responses to supercooling and hypoxia in the hatchling painted turtle, Chrysemys picta.
Topics: Animals; Animals, Newborn; Body Temperature; Cold Temperature; Glucose; Glycerol; Hypoxia; Lactic Ac | 2001 |
Blood lactate exchange and removal abilities after relative high-intensity exercise: effects of training in normoxia and hypoxia.
Topics: Adult; Exercise; Female; Humans; Hypoxia; Lactic Acid; Longitudinal Studies; Male; Oxygen; Oxygen Co | 2001 |
Effect of changing tumor oxygenation on glycolytic metabolism in a murine C3H mammary carcinoma assessed by in vivo nuclear magnetic resonance spectroscopy.
Topics: Animals; Blood Glucose; Carbon Dioxide; Carbon Isotopes; Carbon Monoxide; Female; Glucose; Glycolysi | 2001 |
The 'lactate paradox', evidence for a transient change in the course of acclimatization to severe hypoxia in lowlanders.
Topics: Acclimatization; Adult; Hemoglobins; Humans; Hypoxia; Lactic Acid; Male; Mountaineering; Physical Ex | 2000 |
Advanced gestational age and fetal lactate levels in flight.
Topics: Aerospace Medicine; Animals; Female; Fetus; Gestational Age; Humans; Hypoxia; Lactic Acid; Pregnancy | 2001 |
Peak heart rate decreases with increasing severity of acute hypoxia.
Topics: Adaptation, Physiological; Adult; Altitude Sickness; Catecholamines; Exercise; Heart Rate; Humans; H | 2001 |
Anoxia tolerance and anaerobic metabolism in two tropical weevil species (Coleoptera, Curculionidae).
Topics: Adaptation, Physiological; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; A | 2001 |
Live high:train low increases muscle buffer capacity and submaximal cycling efficiency.
Topics: Adaptation, Physiological; Adenosine Triphosphate; Adult; Altitude; Atmosphere Exposure Chambers; Bi | 2001 |
Modulators of haemocyanin oxygen affinity in the hypoxia- and sulphide-tolerant Baltic isopod Saduria entomon (L.).
Topics: Animals; Binding, Competitive; Cations, Divalent; Crustacea; Hemocyanins; Hypoxia; Lactic Acid; Oxyg | 2001 |
[Effects of acute hypoxia on plasma lactic acid and lactic dehydrogenase content in pilots].
Topics: Adult; Aerospace Medicine; Humans; Hypoxia; L-Lactate Dehydrogenase; Lactic Acid; Male; Time Factors | 2000 |
Beta-adrenoceptors mediate inhibition of lipolysis in adipocytes of tilapia (Oreochromis mossambicus).
Topics: Adipocytes; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adren | 2002 |
Gender differences in the endocrine and metabolic responses to hypoxic exercise.
Topics: Adult; Blood Glucose; Cardiovascular System; Differential Threshold; Endocrine Glands; Exercise; Fem | 2002 |
Exposure to hypoxia primes the respiratory and metabolic responses of the epaulette shark to progressive hypoxia.
Topics: Animals; Blood Glucose; Hematocrit; Hypoxia; Lactic Acid; Oxygen; Oxygen Consumption; Sharks | 2002 |
Measurement of interstitial lactate during hypoxia-induced dilatation in isolated pressurised porcine coronary arteries.
Topics: Animals; Coronary Vessels; Dichloroacetic Acid; Dose-Response Relationship, Drug; Extracellular Spac | 2002 |
Is lactate a reliable indicator of tissue hypoxia in the neonatal period?
Topics: Biomarkers; Female; Humans; Hypoxia; Infant, Newborn; Ischemia; Lactates; Lactic Acid; Male; Neonata | 2002 |
Agreement between capillary and arterial lactate in the newborn.
Topics: Biomarkers; Capillaries; Female; Humans; Hypoxia; Infant, Newborn; Intensive Care Units, Neonatal; I | 2002 |
Changes in MCT 1, MCT 4, and LDH expression are tissue specific in rats after long-term hypobaric hypoxia.
Topics: Acclimatization; Altitude; Animals; Atmospheric Pressure; Blotting, Western; Electron Transport Comp | 2002 |
Hypoxia is not the sole cause of lactate production during shock.
Topics: Analysis of Variance; Animals; Epinephrine; Ethanol; Hypoxia; Lactic Acid; Male; Microdialysis; Ouab | 2002 |
Oxygen consumption and force development in turtle and trout cardiac muscle during acidosis and high extracellular potassium.
Topics: Acidosis; Animals; Carbon Dioxide; Cell Respiration; Epinephrine; Heart; Hydrogen-Ion Concentration; | 2002 |
Effects of prevailing hypoxaemia, acidaemia or hypoglycaemia upon the cardiovascular, endocrine and metabolic responses to acute hypoxaemia in the ovine fetus.
Topics: Acid-Base Equilibrium; Acidosis; Acute Disease; Adrenocorticotropic Hormone; Animals; Blood Gas Anal | 2002 |
Low sodium intake does not impair renal compensation of hypoxia-induced respiratory alkalosis.
Topics: Aldosterone; Alkalosis, Respiratory; Angiotensin II; Animals; Arteries; Atrial Natriuretic Factor; B | 2002 |
Increased blood ammonia in hypoxia during exercise in humans.
Topics: Adult; Altitude; Ammonia; Exercise; Humans; Hypoxia; Lactic Acid; Male; Oxygen | 2001 |
The oxygen debt during routine cardiac surgery: illusion or reality?
Topics: Aged; Biological Availability; Coronary Artery Bypass; Female; Humans; Hypoxia; Lactic Acid; Male; M | 2002 |
The influence of acute hypoxia on the prediction of maximal oxygen uptake using multi-stage shuttle run test.
Topics: Adolescent; Adult; Analysis of Variance; Exercise Test; Heart Rate; Humans; Hypoxia; Lactic Acid; Ma | 2002 |
Anti-inflammatory agent, dexamethasone, does not affect exercise-induced arterial hypoxemia in Thoroughbreds.
Topics: Animals; Anti-Inflammatory Agents; Blood Gas Analysis; Carbon Dioxide; Dexamethasone; Female; Heart | 2002 |
1H-NMR spectroscopy of cerebrospinal fluid of fetal sheep during hypoxia-induced acidemia and recovery.
Topics: 3-Hydroxybutyric Acid; Acidosis; Animals; Choline; Citric Acid; Creatinine; Energy Metabolism; Femal | 2002 |
Chronic hypoxia: a model for cyanotic congenital heart defects.
Topics: Adenosine Triphosphate; Animals; Cardiopulmonary Bypass; Chronic Disease; Cyanosis; Disease Models, | 2002 |
Hypoxic liver injury and the ameliorating effects of fructose: the "glucose paradox" revisited.
Topics: Animals; Fructose; Glucose; Glycolysis; Hypoxia; Insulin; Lactates; Lactic Acid; Liver; Perfusion; R | 1992 |
Roles of catecholamines and corticosterone during anoxia and recovery at 5 degrees C in turtles.
Topics: Air; Animals; Blood Glucose; Cold Temperature; Corticosterone; Epinephrine; Hypoxia; Immersion; Lact | 1992 |
Cerebral extracellular glucose and lactate concentrations during and after moderate hypoxia in glucose- and saline-infused rats.
Topics: Animals; Brain; Extracellular Space; Glucose; Hypoxia; Lactates; Lactic Acid; Male; Rats; Rats, Wist | 1992 |
Metabolic adaptation of fetal hindlimb to severe, nonlethal hypoxia.
Topics: Adaptation, Physiological; Animals; Fetal Blood; Fetus; Hindlimb; Hypoxia; Lactates; Lactic Acid; Os | 1992 |
Enzyme mechanisms for pyruvate-to-lactate flux attenuation: a study of Sherpas, Quechuas, and hummingbirds.
Topics: Adaptation, Physiological; Animals; Birds; China; Energy Metabolism; Exercise; Glycolysis; Humans; H | 1992 |
Effects of sustained hypoxemia on the sheep fetus at midgestation: endocrine, cardiovascular, and biophysical responses.
Topics: Animals; Blood Glucose; Carbon Dioxide; Cardiovascular System; Endocrine Glands; Female; Fetal Disea | 1992 |
Exercise-induced hypoxemia in athletes: role of inadequate hyperventilation.
Topics: Adult; Bicycling; Carbon Dioxide; Humans; Hyperventilation; Hypoxia; Lactates; Lactic Acid; Male; Ox | 1992 |
ATP formation and energy demand in anoxic heart muscle of the rabbit.
Topics: Adenosine Triphosphate; Animals; Electric Stimulation; Energy Metabolism; Glucose; Hypoxia; In Vitro | 1992 |
Hypoxia induces glucose transporter expression in endothelial cells.
Topics: Animals; Cell Survival; Cells, Cultured; Creatine Kinase; Endothelium, Vascular; Glucose; Hypoxia; L | 1992 |
Right and left ventricular function in fetal sheep exposed to long-term high-altitude hypoxemia.
Topics: Altitude; Animals; Cardiac Output; Catecholamines; Fetal Diseases; Fetal Heart; Gases; Hemodynamics; | 1992 |
Postanoxic oxidative injury in rat hepatocytes: lactate-dependent protection against tert-butylhydroperoxide.
Topics: Animals; Free Radicals; Hypoxia; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Liver; Male; NAD; O | 1992 |
Effect of dichloroacetate on mechanical performance and metabolism of compromised diaphragm muscle.
Topics: Animals; Diaphragm; Dichloroacetic Acid; Electric Stimulation; Glucose; Hypoxia; In Vitro Techniques | 1992 |
[Metabolic factors of vasomotor regulation of the inner retina].
Topics: Animals; Blood-Retinal Barrier; Energy Metabolism; Hypoxia; Lactates; Lactic Acid; Retinal Vessels; | 1992 |
Oxygen transport during anemic hypoxia in pigs: effects of digoxin on metabolism.
Topics: Anemia; Animals; Biological Availability; Biological Transport; Catecholamines; Digoxin; Hematocrit; | 1992 |
Effects of hypoxia on the contractions and lactate release induced by high-K+, ouabain and epinephrine in guinea-pig aorta.
Topics: Anaerobiosis; Animals; Aorta, Thoracic; Calcium; Epinephrine; Extracellular Space; Guinea Pigs; Hypo | 1991 |
Low oxygen delivery produced by anemia, hypoxia, and low cardiac output.
Topics: Anemia; Animals; Cardiac Output, Low; Dogs; Hypoxia; Lactates; Lactic Acid; Oxygen Consumption; Ther | 1991 |
Effect of hypoxia on cerebral metabolites measured by proton nuclear magnetic resonance spectroscopy in rats.
Topics: Animals; Aspartic Acid; Brain; Hyperglycemia; Hypoglycemia; Hypoxia; Lactates; Lactic Acid; Magnetic | 1991 |
Differences in glycolytic capacity and hypoxia tolerance between hepatoma cells and hepatocytes.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Anaerobiosis; Animals; Carci | 1991 |
Skeletal muscle metabolism and work capacity: a 31P-NMR study of Andean natives and lowlanders.
Topics: Acclimatization; Adenosine Triphosphate; Adult; Altitude; Energy Metabolism; Humans; Hypoxia; Lactat | 1991 |
31P-NMR study of normoxic and anoxic perfused turtle heart during graded CO2 and lactic acidosis.
Topics: Acidosis, Lactic; Adenosine Triphosphate; Animals; Carbon Dioxide; Female; Heart; Heart Rate; Hydrog | 1991 |
DNA synthesis is reduced in selected fetal tissues during prolonged hypoxemia.
Topics: Adrenal Glands; Animals; Blood Glucose; Body Weight; Carbon Dioxide; DNA; Female; Fetus; Hydrogen-Io | 1991 |
Vascular lactic acid infusions do not alter the incidence of fetal breathing movements or their inhibition by acute hypoxemia.
Topics: Acidosis, Lactic; Animals; Blood Glucose; Blood Pressure; Carbon Dioxide; Female; Heart Rate; Hypoxi | 1991 |
The energy requirements for the basal efflux of 3H-noradrenaline from sympathetically innervated organs.
Topics: Animals; Atrial Function; Biological Transport; Calcium; Catechol O-Methyltransferase Inhibitors; De | 1991 |
Metabolic and developmental responses of the calf to a chronic hypoxic episode in the immediate newborn period.
Topics: Animals; Animals, Newborn; Bicarbonates; Blood Glucose; Carbon Dioxide; Cattle; Hydrogen-Ion Concent | 1990 |
Shift of anaerobic to aerobic metabolism in the rats acclimatized to hypoxia.
Topics: Acclimatization; Altitude; Animals; Energy Metabolism; Glycolysis; Hypoxia; Ketone Bodies; Lactates; | 1990 |
Hepatic oxygen and lactate extraction during stagnant hypoxia.
Topics: Animals; Dogs; Hemodynamics; Hypoxia; In Vitro Techniques; Lactates; Lactic Acid; Liver; Male; Oxyge | 1991 |
Protection of ischaemic synaptosomes from calcium overload by addition of exogenous lactate.
Topics: Acetylcholine; Animals; Brain Ischemia; Calcium; Hydrogen-Ion Concentration; Hypoxia; Lactates; Lact | 1991 |
Metabolic and work efficiencies during exercise in Andean natives.
Topics: Acclimatization; Adenosine Triphosphate; Adult; Altitude; Blood Glucose; Body Water; Energy Metaboli | 1991 |
Lactate utilization by neonatal rat liver in vitro.
Topics: Animals; Animals, Newborn; Female; Hypoxia; In Vitro Techniques; Lactates; Lactic Acid; Liver; Pregn | 1990 |
Influence of phospholipid polyunsatured fatty acid composition on some metabolic disorders induced in rat cardiomyocytes by hypoxia and reoxygenation.
Topics: Adenine Nucleotides; Animals; Cells, Cultured; Energy Metabolism; Fatty Acids, Unsaturated; Hypoxia; | 1990 |
Epicardial oxygen tensions during changes in arterial PO2 in pigs.
Topics: Animals; Hemodynamics; Hypoxia; Lactates; Lactic Acid; Myocardium; Oxygen; Swine | 1990 |
Hypoxia tolerance of coronary endothelial cells.
Topics: Adenine Nucleotides; Animals; Cells, Cultured; Endothelium, Vascular; Energy Metabolism; Glycolysis; | 1990 |
Aerobic glycolysis in the retina of the crab Ocypode ryderi.
Topics: Aerobiosis; Animals; Brachyura; Extracellular Space; Glycolysis; Hydrogen-Ion Concentration; Hypoxia | 1990 |
Acid-base characteristics of steady-state exercise in rats adapted to simulated altitude.
Topics: Acclimatization; Acid-Base Equilibrium; Altitude; Animals; Hemoglobins; Hydrogen-Ion Concentration; | 1990 |
O2 supply dependency in patients without hyperlactemia.
Topics: Cardiac Output; Critical Care; Dobutamine; Humans; Hypoxia; Lactates; Lactic Acid; Norepinephrine; O | 1990 |
[Behavior of various enzyme activities during high blood lactate and pyruvate levels in albino rats reared in a normobaric hypoxic atmosphere for 1 or 2 generations].
Topics: Acid-Base Equilibrium; Adaptation, Physiological; Animals; Atmosphere Exposure Chambers; Creatine Ki | 1990 |
Importance of fatty acid oxidation in the neonatal pig heart with hypoxia and reoxygenation.
Topics: Animals; Animals, Newborn; Blood Pressure; Carbon Dioxide; Fatty Acids; Heart; Hypoxia; In Vitro Tec | 1990 |
Influence of glucose and insulin on the exaggerated diastolic and systolic dysfunction of hypertrophied rat hearts during hypoxia.
Topics: Animals; Cardiomegaly; Diastole; Glucose; Heart; Hypoxia; Insulin; Lactates; Lactic Acid; Male; Osmo | 1990 |
Increased ischemic injury but decreased hypoxic injury in hypertrophied rat hearts.
Topics: Adenosine Triphosphate; Animals; Aorta; Cardiomegaly; Constriction; Coronary Disease; Glycogen; Hear | 1990 |
Responses of harbor seal and pig heart to progressive and acute hypoxia.
Topics: Acute Disease; Animals; Energy Metabolism; Heart; Hemodynamics; Hemoglobins; Hydrogen-Ion Concentrat | 1990 |
Posthypoxic glucose supplement reduces hypoxic-ischemic brain damage in the neonatal rat.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Brain Chemistry; Brain Ischemia; Cerebral Cortex; Cer | 1990 |
Depressed gluconeogenesis and ureogenesis in isolated hepatocytes after intermittent hypoxia in rats.
Topics: Adenosine Triphosphate; Animals; Gluconeogenesis; Hypoxia; In Vitro Techniques; Lactates; Lactic Aci | 1990 |
Increased lactate appearance and reduced clearance during hypoxia in dogs.
Topics: Animals; Blood Pressure; Dogs; Glucose; Hypoxia; Lactates; Lactic Acid; Metabolic Clearance Rate; Ti | 1990 |
Brain pH in acute isocapnic metabolic acidosis and hypoxia: a 31P-nuclear magnetic resonance study.
Topics: Acid-Base Imbalance; Acidosis; Animals; Brain; Hydrochloric Acid; Hydrogen; Hydrogen-Ion Concentrati | 1990 |
Attenuation of vasopressin-mediated coronary constriction and myocardial depression in the hypoxic heart.
Topics: Animals; Arginine Vasopressin; Cardiomyopathies; Coronary Circulation; Coronary Vessels; Heart; Hypo | 1990 |
Involvement of lactic acidosis in anoxia-induced perturbations of synaptosomal function.
Topics: Acidosis, Lactic; Animals; Glucose; Hypoxia; Lactates; Lactic Acid; Male; Rats; Rats, Inbred Strains | 1990 |
Effects of hypoxia on high-energy phosphagen content, energy metabolism and isometric force in guinea-pig taenia caeci.
Topics: Adenine Nucleotides; Aerobiosis; Animals; Calcium; Carbachol; Diltiazem; Energy Metabolism; Guinea P | 1990 |
Effect of probenecid on cerebral and cisternal cerebrospinal fluid lactate content.
Topics: Animals; Brain; Cisterna Magna; Energy Metabolism; Glucose; Homovanillic Acid; Hydroxyindoleacetic A | 1987 |
Relationship of myocardial metabolism and coronary flow: dependence on extracellular calcium.
Topics: Adenosine Triphosphate; Amobarbital; Animals; Calcium; Calcium Channel Blockers; Coronary Circulatio | 1987 |
The effects of 4-pentenoic and pentanoic acid on the hypoxic rat atria.
Topics: Animals; Fasting; Fatty Acids, Monounsaturated; Female; Heart Atria; Hypoxia; In Vitro Techniques; L | 1989 |
Reduced systolic blood pressure elevations during maximum exercise at simulated altitudes.
Topics: Adult; Altitude; Atmosphere Exposure Chambers; Blood Pressure; Catecholamines; Exercise; Female; Hum | 1989 |
Delayed neurologic deterioration following anoxia: brain mitochondrial and metabolic correlates.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Blood Glucose; Brain; Carbon Dioxide; Cats; | 1989 |
The effect of etomidate pretreatment on cerebral high energy metabolites, lactate, and glucose during severe hypoxia in the rat.
Topics: Animals; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Energy Metabolism; Etomidate; Glu | 1989 |
Decreased exercise muscle lactate release after high altitude acclimatization.
Topics: Acclimatization; Adult; Altitude; Exercise; Femoral Artery; Humans; Hypoxia; Iliac Vein; Lactates; L | 1989 |
[Comparative effects of dichloroacetate and sodium bicarbonate on plasma lactic acid levels in experimentally produced hypoxia].
Topics: Acetates; Acidosis, Lactic; Animals; Bicarbonates; Dichloroacetic Acid; Dogs; Hemodynamics; Hypoxia; | 1987 |
Improved hemodynamic function during hypoxia with Carbicarb, a new agent for the management of acidosis.
Topics: Acidosis, Lactic; Animals; Bicarbonates; Blood Gas Analysis; Carbonates; Cardiac Output; Dogs; Drug | 1988 |
Plasma adrenocorticotrophin and cortisol responses to acute hypoxia at rest and during exercise.
Topics: Adrenocorticotropic Hormone; Adult; Heart Rate; Humans; Hydrocortisone; Hypoxia; Lactates; Lactic Ac | 1988 |
The role of the adrenal medulla and peripheral sympathetic nerves in the physiological responses of the fetal sheep to hypoxia.
Topics: Adrenal Medulla; Adrenocorticotropic Hormone; Animals; Blood Gas Analysis; Blood Glucose; Blood Pres | 1988 |
Stimulation of anaerobic metabolism in rats at high altitude hypoxia--adrenergic effects dependent on dietary states.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Altitude Sickness; Anaerobiosis; Animals; | 1987 |
Experimental chronic hypoxic neuropathy: relevance to diabetic neuropathy.
Topics: Animals; Diabetic Neuropathies; Disease Models, Animal; Electrophysiology; Glycated Hemoglobin; Hexo | 1986 |
Role of adrenergic-dependent H+ release from red cells in acidosis induced by hypoxia in trout.
Topics: Acidosis; Animals; Erythrocytes; Hemoglobins; Hydrogen; Hydrogen-Ion Concentration; Hypoxia; Kinetic | 1987 |
Pyruvate attenuation of hypoxia damage in isolated working guinea-pig heart.
Topics: Animals; Carbon Dioxide; Cardiomyopathies; Deoxyglucose; Fatty Acids; Glucose; Guinea Pigs; Heart; H | 1986 |
CO2 sensitivity of cat phrenic neurogram during hypoxic respiratory depression.
Topics: Animals; Carbon Dioxide; Cats; Dichloroacetic Acid; Hypoxia; Lactates; Lactic Acid; Male; Phrenic Ne | 1988 |
Bioenergetics of rabbit skeletal muscle during hypoxemia and ischemia.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Blood Pressure; Energy Metabolism; Hydrogen-Ion Conc | 1988 |
Limitation of maximal O2 uptake and performance by acute hypoxia in dog muscle in situ.
Topics: Acid-Base Equilibrium; Animals; Dogs; Female; Hindlimb; Hydrogen-Ion Concentration; Hypoxia; Lactate | 1988 |
The influence of fentanyl upon cerebral high-energy metabolites, lactate, and glucose during severe hypoxia in the rat.
Topics: Adenosine Triphosphate; Animals; Brain; Electroencephalography; Energy Metabolism; Fentanyl; Glucose | 1988 |
Concentration of hypoxanthine in both cerebrospinal fluid and brain tissue increases under intensive hypoxia only.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Blood Glucose; Brain; Glycogen; Hypoxanthine; Hyp | 1988 |
Effects of acute hypoxia and reoxygenation in a blood-perfused neonatal heart model.
Topics: Acute Disease; Animals; Animals, Newborn; Blood; Energy Metabolism; Heart; Hypoxia; Lactates; Lactic | 1988 |
Role of brain lactic acidosis in hypoxic depression of respiration.
Topics: Acidosis, Lactic; Animals; Brain; Carbon Monoxide; Cats; Chemoreceptor Cells; Denervation; Dichloroa | 1988 |
Evidence in vivo that most of the intraluminally absorbed glucose is absorbed intact into the portal vein and not metabolized to lactate.
Topics: Absorption; Aerobiosis; Animals; Aorta; Blood Glucose; Glucose; Hypoxia; Lactates; Lactic Acid; Male | 1988 |
Change in plasma amino acid concentrations during breath-hold diving at high altitude.
Topics: Adult; Altitude; Amino Acids; Anaerobiosis; Dietary Proteins; Diving; Humans; Hypoxia; Lactates; Lac | 1988 |
Fluid-electrolyte shift and renin-aldosterone responses to exercise under hypoxia.
Topics: Adult; Aldosterone; Catecholamines; Humans; Hypoxia; Lactates; Lactic Acid; Male; Oxygen Consumption | 1987 |
Synergistic effects of hypoxia and fasting on harmol elimination in the isolated perfused rat liver.
Topics: Alkaloids; Animals; Fasting; Glucose; Harmine; Hypoxia; In Vitro Techniques; Lactates; Lactic Acid; | 1988 |
Uptake of exogenous substrates during hypoxia in fetal lambs.
Topics: Algorithms; Animals; Blood Glucose; Female; Fetus; Hypoxia; Lactates; Lactic Acid; Maternal-Fetal Ex | 1988 |
Relating cerebral ischemia and hypoxia to insult intensity.
Topics: Adenine Nucleotides; Animals; Brain; Cerebrovascular Circulation; Creatine; Dogs; Glucose; Glycogen; | 1988 |
Hypoxanthine and lactate concentrations in lambs during hypoxic and stagnant hypoxia.
Topics: Algorithms; Animals; Cardiac Output; Hypoxanthine; Hypoxanthines; Hypoxia; Lactates; Lactic Acid; Ox | 1988 |
The effect of mild hypoxemia maintained for twenty-four hours on maternal and fetal glucose, lactate, cortisol, and arginine vasopressin in pregnant sheep at 122 to 139 days' gestation.
Topics: Animals; Arginine Vasopressin; Blood Glucose; Female; Fetal Blood; Fetal Diseases; Gestational Age; | 1987 |
Relationship between myocardial CK release, high energy phosphate metabolism and ultrastructure as effect of anoxia on isolated rat heart.
Topics: Animals; Coronary Circulation; Creatine Kinase; Heart; Hypoxia; In Vitro Techniques; Lactates; Lacti | 1987 |
Effect of hypoxia on lactate variables during exercise.
Topics: Adult; Anaerobiosis; Energy Metabolism; Exercise Test; Humans; Hypoxia; Lactates; Lactic Acid | 1987 |
Metabolic and endocrine responses to graded exercise under acute hypoxia.
Topics: Adult; Androstenedione; Blood Glucose; Energy Metabolism; Exercise Test; Fatty Acids, Nonesterified; | 1986 |
[Effect of dichloroacetate on plasma lactic acid in experimentally produced hypoxia].
Topics: Acetates; Acidosis, Lactic; Animals; Dichloroacetic Acid; Dogs; Hemodynamics; Hypoxia; Lactates; Lac | 1986 |
Measurement of glucose and 2-deoxy-2-[18F]fluoro-D-glucose transport and phosphorylation rates in myocardium using dual-tracer kinetic experiments.
Topics: Animals; Biological Transport; Deoxy Sugars; Deoxyglucose; Fluorodeoxyglucose F18; Glucose; Heart Se | 1987 |
Glycolytic activity and enhancement of serotonin uptake by endothelial cells exposed to hypoxia/anoxia.
Topics: Adenosine Triphosphate; Animals; Cattle; Cell Division; Cells, Cultured; Endothelium; Glycolysis; Hy | 1987 |
Effects of components of ischemia and metabolic inhibition on delayed afterdepolarizations in guinea pig papillary muscle.
Topics: Acidosis; Action Potentials; Animals; Coronary Disease; Cyanides; Deoxyglucose; Guinea Pigs; Heart C | 1987 |
Pathophysiology of type A hypoxic lactic acidosis in dogs.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Dogs; Hemodynamics; Hypoxia; Lactates; Lactic Acid; Oxygen | 1987 |
Simultaneous 31P- and 1H-nuclear magnetic resonance studies of hypoxia and ischemia in the cat brain.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Cats; Electroencephalography; Hydrogen; Hypo | 1987 |
Oxygen transport and metabolism in the conscious lamb: the effects of hypoxemia.
Topics: Age Factors; Animals; Animals, Newborn; Biological Transport, Active; Hypoxia; Lactates; Lactic Acid | 1987 |
Role of adenosine in mediating the coronary vasodilative response to acute hypoxia.
Topics: Acute Disease; Adenosine; Adenosine Deaminase; Animals; Coronary Circulation; Coronary Vessels; Hemo | 1987 |
Skeletal muscle energetics, acid-base equilibrium and lactate metabolism in patients with severe hypercapnia and hypoxemia.
Topics: Acid-Base Equilibrium; Acute Disease; Adenosine Triphosphate; Aged; Energy Metabolism; Female; Human | 1987 |
[Effects of ginsenosides on myocardial lactic acid, cyclic nucleotides and ultrastructural myocardial changes in anoxia in mice].
Topics: Animals; Brain Chemistry; Ginsenosides; Hypoxia; Lactates; Lactic Acid; Male; Mice; Mitochondria, He | 1987 |
Time course of muscular blood metabolites during forearm rhythmic exercise in hypoxia.
Topics: Adult; Altitude Sickness; Hemoglobins; Humans; Hydrogen-Ion Concentration; Hypoxia; Lactates; Lactic | 1986 |
Effects of exercise in normoxia and acute hypoxia on respiratory muscle metabolites.
Topics: Animals; Diaphragm; Glycogen; Hypoxia; Intercostal Muscles; Lactates; Lactic Acid; Male; Muscle, Smo | 1986 |
Cardiovascular effects of d-tubocurarine and pancuronium in newborn lambs during normoxia and hypoxia.
Topics: Animals; Animals, Newborn; Blood Gas Analysis; Blood Pressure; Cardiac Output; Cardiovascular System | 1986 |
Changes in metabolite levels and morphology of teleost ventricular myocytes due to hypoxia, ischaemia, and metabolic inhibitors.
Topics: Adenosine Triphosphate; Animals; Fishes; Heart Ventricles; Humans; Hypoxia; Ischemia; Lactates; Lact | 1986 |
[Concentration of lactic acid in the blood and erythropoiesis during exposure to hypoxia].
Topics: Acclimatization; Altitude; Animals; Erythropoiesis; Hemoglobins; Hemorrhage; Hypoxia; Lactates; Lact | 1986 |
Substrates induce hypoxic injury to medullary thick limbs of isolated rat kidneys.
Topics: Animals; Glomerular Filtration Rate; Hypoxia; In Vitro Techniques; Kidney Diseases; Kidney Tubules; | 1986 |
Energy deficits in hepatocytes isolated from phenobarbital-treated or fasted rats and briefly exposed to halothane and hypoxia in vitro.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Analysis of Variance; Animals; Energy Metabolism; Fas | 1986 |
Effects of in vitro anoxia and low pH on acetylcholine release by rat brain synaptosomes.
Topics: Acetylcholine; Animals; Brain; Calcium; Choline; Hydrogen-Ion Concentration; Hypoxia; In Vitro Techn | 1987 |
Lactic acidosis in fulminant hepatic failure. Some aspects of pathogenesis and prognosis.
Topics: Acidosis; Blood Pressure; Carbon Dioxide; Female; Humans; Hypoxia; Lactates; Lactic Acid; Liver Dise | 1985 |
Functional compartmentation of glycolytic versus oxidative metabolism in isolated rabbit heart.
Topics: Animals; Azides; Dinitrophenols; Glycolysis; Heart; Hypoxia; In Vitro Techniques; Iodoacetates; Iodo | 1985 |
[Blood lactate in chronic obstructive pulmonary disease with chronic cor pulmonale].
Topics: Aged; Female; Humans; Hypoxia; Lactates; Lactic Acid; Lung Diseases, Obstructive; Male; Middle Aged; | 1985 |
Effect of hypoxia on oxidative and reductive pathways of omeprazole metabolism by the isolated perfused rat liver.
Topics: Animals; Benzimidazoles; Hypoxia; Lactates; Lactic Acid; Liver; Male; Omeprazole; Oxidation-Reductio | 1985 |
The concentration of hypoxanthine and lactate in the blood of healthy and hypoxic newborns.
Topics: Acid-Base Equilibrium; Apgar Score; Asphyxia Neonatorum; Humans; Hypoxanthine; Hypoxanthines; Hypoxi | 1985 |
[Relation between glycohemoglobin, hypoxia parameters and diabetic microangiopathy].
Topics: 2,3-Diphosphoglycerate; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diabetic Re | 1985 |
Efflux of metabolized and nonmetabolized fatty acid from canine myocardium. Implications for quantifying myocardial metabolism tomographically.
Topics: Animals; Dogs; Fatty Acids; Hemodynamics; Hypoxia; Kinetics; Lactates; Lactic Acid; Mathematics; Myo | 1985 |
[Effect of short-term hypoxia on body temperature and lactic acid in the blood of the mouse].
Topics: Adaptation, Physiological; Altitude; Animals; Body Temperature; Female; Hypoxia; Lactates; Lactic Ac | 1985 |
Metabolic responses of the kidney in fetal sheep: effect of acute and spontaneous hypoxemia.
Topics: Animals; Blood Gas Analysis; Blood Glucose; Carbohydrate Metabolism; Catheters, Indwelling; Female; | 1985 |
Response of the isolated heart to carbon monoxide and nitrogen anoxia.
Topics: Animals; Carbon Monoxide; Electric Stimulation; Glycogen; Heart; Heart Rate; Hypoxia; Lactates; Lact | 1985 |
[Gas exchange and metabolic functions of the lungs in endotoxic shock].
Topics: Acidosis, Respiratory; Animals; Dogs; Female; Hydrogen-Ion Concentration; Hypoxia; Lactates; Lactic | 1985 |