lactic acid and Anoxemia studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Research Excerpts

Excerpt	Relevance	Reference
"The purpose of the present investigation was to determine the independent effects of hypoxia and physical exercise on peripheral cholecystokinin (CCK) metabolism in humans."	9.09	Physical exercise and normobaric hypoxia: independent modulators of peripheral cholecystokinin metabolism in man. ( Bailey, DM; Calam, J; Castell, LM; Davies, B; Newsholme, EA, 2001)
"In this study the authors examine the effects of acute hypoxia due to extracorporeal circulation (ECC) and the role played by L-carnitine treatment on some plasmatic metabolites linked to glycolytic cellular metabolism."	9.07	Metabolic aspects of acute tissue hypoxia during extracorporeal circulation and their modification induced by L-carnitine treatment. ( Cogliatti, A; Corbucci, GG; Menichetti, A; Nicoli, P; Ruvolo, C, 1992)
"L-lactic acidosis (L-LA) is the most common cause of metabolic acidosis in the critical care setting, which has been associated with a large increase in mortality."	9.05	L-lactic acidosis: pathophysiology, classification, and causes; emphasis on biochemical and metabolic basis. ( Halperin, ML; Kamel, KS; Oh, MS, 2020)
"This study suggests that caffeic acid inhibits PHD2 enzyme activity which then activates the hypoxia-associated transcription factor HIF leading to a neuroprotective effect against hypoxia."	8.12	The novel prolyl hydroxylase-2 inhibitor caffeic acid upregulates hypoxia inducible factor and protects against hypoxia. ( Diao, A; Guo, B; Guo, Z; Hao, L; Li, L; Li, Y; Liu, Z; Yang, Y; Zhao, Q, 2022)
" Initial severe acidosis consisted of acute respiratory acidosis from ventilation-perfusion mismatch and acute metabolic acidosis resulting from bronchospasm and hypoxia-related lactic acidosis, respectively."	8.02	Salbutamol-induced lactic acidosis in status asthmaticus survivor. ( Boonkaya, S; Phoophiboon, V; Singhagowinta, P; Sriprasart, T, 2021)
"The present study is an attempt to leverage therapeutic benefits of curcumin in pulmonary hypertension by encapsulating it in biodegradable poly(lactide-co-glycolic) acid nanoparticles."	7.78	Tissue localization of nanoparticles is altered due to hypoxia resulting in poor efficacy of curcumin nanoparticles in pulmonary hypertension. ( Devadasu, VR; Ravi Kumar, MN; Wadsworth, RM, 2012)
" Two important determinants in this environment are hypoxia and lactic acidosis."	7.74	The genomic analysis of lactic acidosis and acidosis response in human cancers. ( Chen, JL; Chi, JT; Dewhirst, M; Lucas, JE; Mori, S; Nevins, J; Schroeder, T; West, M; Wu, J, 2008)
" A randomized controlled study was designed to examine the dose-response effect of dobutamine (5-20 microg x kg(-1) x min(-1)) on systemic and regional circulations and oxygen metabolism in a neonatal swine model of hypoxia/reoxygenation."	7.74	The hemodynamic effects of dobutamine during reoxygenation after hypoxia: a dose-response study in newborn pigs. ( Abozaid, S; Al-Salam, Z; Bigam, D; Cheung, PY; Johnson, S, 2007)
"We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model."	7.73	Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005)
" To gain a better understanding of the mechanisms responsible for oxygen and nutrient sensing in chondrocytes, we investigated the effects of hypoxic stimulation induced by cobalt chloride treatment (a hypoxia-mimetic) on glucose uptake and lactate production in chondrocytes."	7.73	Regulation of 2-deoxy-D-glucose transport, lactate metabolism, and MMP-2 secretion by the hypoxia mimetic cobalt chloride in articular chondrocytes. ( Mobasheri, A; Platt, N; Shakibaei, M; Thorpe, C, 2006)
" We hypothesized that ephedrine and phenylephrine, administered for maternal hypotension following fetal hypoxaemia, are equal in respect of fetal outcome."	7.72	Effects of ephedrine and phenylephrine on uterine and placental circulations and fetal outcome following fetal hypoxaemia and epidural-induced hypotension in a sheep model. ( Alahuhta, S; Erkinaro, T; Kavasmaa, T; Mäkikallio, K; Räsänen, J, 2004)
" To study the effect of acute moderate hypoxia on plasma lactic acid (LA) and lactic dehydrogenase (LDH) content in pilots."	7.70	[Effects of acute hypoxia on plasma lactic acid and lactic dehydrogenase content in pilots]. ( Li, WB; Liu, Y; Qin, SZ, 2000)
"The influence of systemic hypoxia on lactate and adenosine output from isolated constant-flow-perfused gracilis muscle was determined in anesthetized dogs."	7.69	Intracellular lactate controls adenosine output from dog gracilis muscle during moderate systemic hypoxia. ( Ballard, HJ; Mo, FM, 1997)
"The role of inhibition of the CPT enzymes responsible for accumulation of long chain acylcarnitines (LCAC) during hypoxia in the proximal tubule has not been previously examined."	7.69	Carnitine palmitoyl-transferase enzyme inhibition protects proximal tubules during hypoxia. ( Portilla, D, 1997)
"We tested whether digoxin would limit tissue hypoxia during severe anemia by improving peripheral O2 distribution or decreasing O2 demands."	7.68	Oxygen transport during anemic hypoxia in pigs: effects of digoxin on metabolism. ( Hendler, R; Lister, G; Saltiel, A; Sanfilippo, DJ, 1992)
"The relationships between the concentrations of glycogen, glucose, lactate, adenosine triphosphate (ATP) and hypoxanthine in the brain tissue, and the hypoxanthine and lactate concentration in cerebrospinal fluid and blood were examined after exposure of rats to hypoxia."	7.67	Concentration of hypoxanthine in both cerebrospinal fluid and brain tissue increases under intensive hypoxia only. ( Gross, J; Lun, A; Pohle, R; Siggel, H, 1988)
"The role of lactic acidosis of progressive brain hypoxia (PBH) as both a central chemoreceptor stimulant and a general respiratory depressant was assessed by preventing lactate formation both locally and globally with dichloroacetate (DCA)."	7.67	Role of brain lactic acidosis in hypoxic depression of respiration. ( Edelman, NH; Neubauer, JA; Simone, A, 1988)
"To determine the suitability of plasma hypoxanthine as a marker of tissue hypoxia, we studied the relationship of arterial plasma hypoxanthine and blood lactate concentrations to the cumulative O2 deficit during hypoxemia and low cardiac output (hypoxic and stagnant hypoxia, respectively)."	7.67	Hypoxanthine and lactate concentrations in lambs during hypoxic and stagnant hypoxia. ( Kurzner, S; Lister, G; Moss, M; Razlog, Y, 1988)
"Hypoxic lactic acidosis (HLA) was induced in dogs by ventilating them with a hypoxic gas mixture of 8% O2-92% N2."	7.67	Pathophysiology of type A hypoxic lactic acidosis in dogs. ( Arieff, AI; Graf, H, 1987)
"To test the hypothesis that adenosine is required to mediate the coronary vasodilative response to acute hypoxia haemodynamic indices, regional myocardial blood flow, and oxygen and lactate metabolism were measured in nine closed chest anaesthetised domestic swine at control, after 3-5 min of 100% nitrogen inhalation, at second control, and after 3-5 min of 100% nitrogen inhalation plus adenosine deaminase infusion in the left anterior descending coronary artery."	7.67	Role of adenosine in mediating the coronary vasodilative response to acute hypoxia. ( Gewirtz, H; Most, AS; Olsson, RA, 1987)
"Experimental factors implicated in the pathogenesis of halothane hepatotoxicity in the phenobarbital-hypoxia rat model were examined for direct effects on the energy status of isolated rat liver cells in vitro."	7.67	Energy deficits in hepatocytes isolated from phenobarbital-treated or fasted rats and briefly exposed to halothane and hypoxia in vitro. ( Albrecht, RF; Becker, GL; Hensel, P; Holland, AD; Miletich, DJ, 1986)
"The effect of hypoxia on the elimination of omeprazole, a potent inhibitor of gastric acid secretion, was studied in the isolated perfused rat liver."	7.67	Effect of hypoxia on oxidative and reductive pathways of omeprazole metabolism by the isolated perfused rat liver. ( Jones, DB; Mihaly, GW; Morgan, DJ; Smallwood, RA; Webster, LK, 1985)
"In mice, changes of body temperature and concentration of lactic acid in the blood were studied after three modes of barochamber hypoxia (altitude 8000 m) at the temperatures +10, +20 and +36 degrees C."	7.67	[Effect of short-term hypoxia on body temperature and lactic acid in the blood of the mouse]. ( Pisarenko, SN; Sepisheva, AS; Slonim, AD, 1985)
"The possibility of detecting past hypoxia during the first 2 h after birth by means of blood analyses of hypoxanthine, lactate, base deficit, and pH was investigated in six infants with a 1 min Apgar score of less than or equal to 4."	7.66	Hypoxanthine as a test of perinatal hypoxia as compared to lactate, base deficit, and pH. ( Bratteby, LE; Swanström, S, 1982)
"During prolonged anoxia at low temperature, freshwater turtles develop high plasma concentrations of both lactate and calcium."	6.42	Surviving extreme lactic acidosis: the role of calcium lactate formation in the anoxic turtle. ( Jackson, DC, 2004)
"This study demonstrates that acute high altitude hypoxia upregulated the lactic acid/amino acid-pyruvate-TCA pathways and fatty acid oxidation, but downregulated glycolysis in the liver of mice."	5.91	Energy metabolic mechanisms for high altitude sickness: Downregulation of glycolysis and upregulation of the lactic acid/amino acid-pyruvate-TCA pathways and fatty acid oxidation. ( Jiang, C; Li, Y; Liao, N; Liu, G; Shang, X; Shao, D; Shi, J; Xu, F; Yin, D, 2023)
"Ischemia was followed by a significant increase in muscle myeloperoxidase activity, as well as interleukin-6 and thiobarbituric acid reactive substances species levels."	5.48	N-acetylcysteine effects on a murine model of chronic critical limb ischemia. ( Constantino, L; da Silva, LA; Dal-Pizzol, F; Dall'Igna, DM; de Medeiros, WA; Dos Santos Cardoso, J; Manfredini, A; Michels, M; Ritter, C; Scaini, G; Streck, EL; Vuolo, F, 2018)
"High uric acid (UA) has been found to be correlated with renal dysfunction in some experimental and clinical studies; however, the study of the dynamic correlation between AKI and UA in severe burns is still lacking."	5.42	Elevated serum uric acid after injury correlates with the early acute kidney in severe burns. ( Hu, X; Liang, J; Zhang, P; Zhi, L, 2015)
"Adenosine is a product of adenylate phosphate breakdown that can exert protective effects on tissues during energy limitation."	5.32	Cardiorespiratory and tissue adenosine responses to hypoxia and reoxygenation in the short-horned sculpin Myoxocephalus scorpius. ( Driedzic, WR; Maccormack, TJ, 2004)
"During sow parturition, there is need for an alternative uterotonic to oxytocin with less potency so piglets are not at risk of hypoxia and stillbirth."	5.30	Effects of oxytocin and carbetocin on farrowing performance. ( Kirkwood, RN; Plush, KL; Ward, SA, 2019)
"To evaluate the effect of hypoxemia on cardiac release of neuropeptide Y-like immunoreactivity (NPY-LI) and norepinephrine (NE), arterial and coronary sinus blood was sampled and coronary sinus blood flow was measured by thermodilution in nine healthy volunteers at rest and during supine cycle ergometer exercise while they breathed air and 12% O2, which reduced arterial O2 saturation to approximately 68%."	5.29	Neuropeptide Y release from human heart is enhanced during prolonged exercise in hypoxia. ( Berglund, B; Grubbström, J; Kaijser, L; Lundberg, JM; Pernow, J, 1994)
"During CO2 acidosis, anoxia had no effect on apparent nonbicarbonate buffer value (d[HCO3-]/dpHi = 71 and 89 mM/pH in normoxia and anoxia, respectively) or on pHi regulation (dpHi/dpHe = 0."	5.28	31P-NMR study of normoxic and anoxic perfused turtle heart during graded CO2 and lactic acidosis. ( Arendt, EA; Inman, KC; Jackson, DC; Lawler, RG; Panol, G; Wasser, JS, 1991)
"The purpose of the present investigation was to determine the independent effects of hypoxia and physical exercise on peripheral cholecystokinin (CCK) metabolism in humans."	5.09	Physical exercise and normobaric hypoxia: independent modulators of peripheral cholecystokinin metabolism in man. ( Bailey, DM; Calam, J; Castell, LM; Davies, B; Newsholme, EA, 2001)
"In this study the authors examine the effects of acute hypoxia due to extracorporeal circulation (ECC) and the role played by L-carnitine treatment on some plasmatic metabolites linked to glycolytic cellular metabolism."	5.07	Metabolic aspects of acute tissue hypoxia during extracorporeal circulation and their modification induced by L-carnitine treatment. ( Cogliatti, A; Corbucci, GG; Menichetti, A; Nicoli, P; Ruvolo, C, 1992)
"L-lactic acidosis (L-LA) is the most common cause of metabolic acidosis in the critical care setting, which has been associated with a large increase in mortality."	5.05	L-lactic acidosis: pathophysiology, classification, and causes; emphasis on biochemical and metabolic basis. ( Halperin, ML; Kamel, KS; Oh, MS, 2020)
" anaerobic glycolysis sustaining ATP production in supramaximal exercise as well as in conditions of hypoxia and ischemia, is responsible for the accumulation of large amounts of lactic acid (up to 1 mol for the whole body)."	4.82	Acid-base balance at exercise in normoxia and in chronic hypoxia. Revisiting the "lactate paradox". ( Cerretelli, P; Samaja, M, 2003)
" These factors (immaturity, hyperoxia, hypoxia, blood transfusions, intraventricular hemorrhage, apnea, infection, hypercarbia, hypocarbia, patent ductus arteriosus, prostaglandin synthetase inhibitors, vitamin E deficiency, lactic acidosis, prenatal complications, genetic factors) may all be present in an infant."	4.76	A reexamination of the role of oxygen in retrolental fibroplasia. ( Dangman, B; Lucey, JF, 1984)
" MCT4 is associated with the export of lactic acid from cancer cells under hypoxia, so inhibition of MCT4 may lead to cytotoxic levels of intracellular lactate."	4.31	Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology. ( Beattie, D; Buttar, D; Clark, R; Cook, CR; Critchlow, SE; Goldberg, FW; Hopcroft, L; Hughes, G; Kavanagh, SL; Kawatkar, A; Kettle, JG; Komen, JC; Lamont, GM; McGuire, TM; Morentin Gutierrez, P; Ting, AKT, 2023)
" As S-adenosylhomocysteine (SAH) was shown to reflect tissue hypoxia, we compared the ability of SAH versus lactate to predict the progression of inflammatory and septic disease to septic organ dysfunction and death."	4.31	S-Adenosylhomocysteine Is a Useful Metabolic Factor in the Early Prediction of Septic Disease Progression and Death in Critically Ill Patients: A Prospective Cohort Study. ( Brohm, K; Centner, FS; Fuderer, T; Hahn, B; Jäger, E; Krebs, J; Lindner, HA; Mindt, S; Neumaier, M; Schneider-Lindner, V; Schoettler, JJ; Thiel, M, 2023)
" Acute poisoning occurred after taking 100 ml of 1,4-butanediol together with phenyl-2- (1-pyrrolidinyl) -1-pentanone and 2 g of methadone, clinically manifested in the form of convulsive syndrome, depression of consciousness to the level of coma 3, edema and swelling brain, acute respiratory failure, mixed decompensated respiratory and metabolic lactic acidosis (pH 7."	4.12	[CLINICAL CASE OF ACUTE SEVERE COMBINED POISONING WITH NARCOTIC SUBSTANCES OF DEPENDENT AND PSYCHOSTIMULATING EFFECTS]. ( Antonova, A; Batotsyrenov, B; Kovalenko, A; Lodyagin, A; Loladze, A; Sinenchenko, A, 2022)
"This study suggests that caffeic acid inhibits PHD2 enzyme activity which then activates the hypoxia-associated transcription factor HIF leading to a neuroprotective effect against hypoxia."	4.12	The novel prolyl hydroxylase-2 inhibitor caffeic acid upregulates hypoxia inducible factor and protects against hypoxia. ( Diao, A; Guo, B; Guo, Z; Hao, L; Li, L; Li, Y; Liu, Z; Yang, Y; Zhao, Q, 2022)
"Hypoxia and high accumulation of lactic acid in the tumor microenvironment provide fertile soil for tumor development, maintenance and metastasis."	4.12	Acidic and hypoxic tumor microenvironment regulation by CaO ( Chang, J; Dong, H; Li, Y; Liu, Y; Ma, X; Ren, T; Ruan, S; Sun, J; Yang, Y; Yin, W; Zang, J, 2022)
" Initial severe acidosis consisted of acute respiratory acidosis from ventilation-perfusion mismatch and acute metabolic acidosis resulting from bronchospasm and hypoxia-related lactic acidosis, respectively."	4.02	Salbutamol-induced lactic acidosis in status asthmaticus survivor. ( Boonkaya, S; Phoophiboon, V; Singhagowinta, P; Sriprasart, T, 2021)
"The pathological expression and function of lactate dehydrogenase A (LDHA), a key enzyme that converts pyruvate into lactic acid during glycolysis, remains unknown in endometriosis."	4.02	Hypoxia‑induced lactate dehydrogenase A protects cells from apoptosis in endometriosis. ( Dai, Y; Huang, Q; Jin, X; Lin, X; Liu, N; Shi, L; Zhang, S; Zheng, J; Zhou, F, 2021)
"In this study, C57BL/6 J mice were administrated with an Nrf2 activator, sulforaphane (SFN) before taking incremental treadmill exercise to exhaustion under hypoxia; then the effects of SFN on exercise endurance and molecular/biochemical makers of the skeletal muscle were evaluated."	3.96	Nrf2 Activation Enhances Muscular MCT1 Expression and Hypoxic Exercise Capacity. ( Wang, J; Wang, L; Yu, S; Zhang, Y; Zhu, R, 2020)
" The effects of different doses of FOPS on the loaded-swimming time, the content of serum urea nitrogen, the blood lactic acid, the hepatic glycogen and the muscle glycogen after exercise, the survival time under hypoxia at normal pressure and the maintenance time after decapitation were observed."	3.91	[Effects of the Fomes officinalis Ames. polysaccharides on anti-fatigue and hypoxia tolerance in mice]. ( Hao, HY; Sha, AL, 2019)
"The effect of lactic acidosis on neurological development in the first year of life."	3.88	Neurological impairments in hypoxic neonates and lactate levels. ( Jovandaric, MZ; Milenkovic, SJ, 2018)
"We evaluated the influence of hypoxic hypoxia on lactate, creatinine and urea concentrations in the amniotic fluid (AF) of rabbits on 27-28th day of pregnancy."	3.85	[Acute hypoxic hypoxia increases lactate concentration in amniotic fluid of rabbits on 27-28th day of pregnancy]. ( Korenovsky, YV; Popovtseva, AV; Suzopov, EV, 2017)
" Biotin-deficient rats show a syndrome characterized by marked weight loss, metabolic lactic acidosis, aciduria and accelerated breathing with normal responsiveness to hypoxia."	3.83	Selective accumulation of biotin in arterial chemoreceptors: requirement for carotid body exocytotic dopamine secretion. ( Arias-Mayenco, I; Bonilla-Henao, V; González-Rodríguez, P; Levitsky, KL; López-Barneo, J; Macías, D; Ortega-Sáenz, P; Rodríguez-Gómez, JA, 2016)
"This study evaluated the effects of thiamine pyrophosphate (PPT) on the biochemical profiles of full-term rabbit foetuses that were subjected to experimental ischemia followed by 24h reperfusion."	3.83	Evaluation of the protective effect of thiamine pyrophosphate based on the biochemical analysis of rabbit foetuses at 30 days of gestation. ( Alonso-Spilsbury, M; Arch-Tirado, E; Jiménez-Bravo, MA; Martínez-Burnes, J; Mora-Medina, P; Mota-Rojas, D; Orozco-Gregorio, H; Pérez-Guille, B; Roldan-Santiago, P; Soriano-Rosales, R, 2016)
"In this study, blood redox potential (ORP) values (ΔORP value was adopted, as the quantitative index to reflect the overall redox status), plasma uric acid levels (important antioxidant, as antioxidant index), and the burn shock state-related indicators (lactic acid and hematocrit) of 48 burn patients were dynamically, quantitatively monitored during the early stage after injury."	3.81	The characteristics and correlation between the ischemia-reperfusion and changes of redox status in the early stage of severe burns. ( Han, C; Hu, H; Hu, X; Pan, X; Shao, H; Xu, J; Yu, C; Zhi, L, 2015)
" These measurements indicate that apoptosis was the primary mechanism of cell death; acidity was not caused by lactic acid; and cell death was caused by depletion of carbon sources and not hypoxia."	3.80	Rapid uptake of glucose and lactate, and not hypoxia, induces apoptosis in three-dimensional tumor tissue culture. ( Forbes, NS; Kasinskas, RW; Venkatasubramanian, R, 2014)
"The present study is an attempt to leverage therapeutic benefits of curcumin in pulmonary hypertension by encapsulating it in biodegradable poly(lactide-co-glycolic) acid nanoparticles."	3.78	Tissue localization of nanoparticles is altered due to hypoxia resulting in poor efficacy of curcumin nanoparticles in pulmonary hypertension. ( Devadasu, VR; Ravi Kumar, MN; Wadsworth, RM, 2012)
" In the present study, both afferent nerves and either of them were activated by muscle contraction, passive tendon stretch, and arterial injection of lactic acid into the hindlimb muscles."	3.78	Role for NGF in augmented sympathetic nerve response to activation of mechanically and metabolically sensitive muscle afferents in rats with femoral artery occlusion. ( Li, J; Lu, J; Xing, J, 2012)
"The effectiveness of sodium bicarbonate (SB) has recently been questioned although it is often used to correct metabolic acidosis of neonates."	3.78	Infusing sodium bicarbonate suppresses hydrogen peroxide accumulation and superoxide dismutase activity in hypoxic-reoxygenated newborn piglets. ( Bigam, DL; Cheung, PY; Lee, TF; Liu, JQ; Manouchehri, N; Yao, M, 2012)
"Intraluminal microdialysis revealed signs of intestinal hypoxia and cellular damage, with a marked increase of lactate and glycerol."	3.78	Intraluminal intestinal microdialysis detects markers of hypoxia and cell damage in experimental necrotizing enterocolitis. ( Carlsson, PO; Hillered, L; Högberg, N; Lilja, HE; Stenbäck, A, 2012)
"Nude mice bearing FaDu, UT-SCC-15, and UT-SCC-5 hSCC were injected with pimonidazole hypoxia and Hoechst perfusion markers."	3.75	Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts. ( Baumann, M; Meyer, S; Mueller-Klieser, W; Quennet, V; Shakirin, G; Walenta, S; Yaromina, A; Zips, D, 2009)
", samples with HMGB-1 levels >2 SD above the mean level in samples from patients with noninflammatory arthropathy), concentrations of HMGB-1 were significantly correlated with those of lactic acid, a marker of tissue hypoxia."	3.74	Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis. ( Abeyama, K; Fukuda, T; Fukuzaki, K; Hamada, T; Hashiguchi, K; Horai, N; Komiya, S; Kuwazuru, A; Maruyama, I; Nagata, R; Nagayama, S; Sunahara, N; Tanaka, M; Torikai, M; Yamada, S, 2008)
"Phosphocreatine (PCr) was reduced to equivalent levels in carp white muscle by high-intensity exhaustive exercise and exposure to hypoxia at 15 degrees C and 25 degrees C in order to assess the influence of intracellular pH (pH(i)), temperature and lactate levels on PCr recovery in vivo."	3.74	Differential recovery from exercise and hypoxia exposure measured using 31P- and 1H-NMR in white muscle of the common carp Cyprinus carpio. ( Hallman, TM; Jones, DR; Richards, JG; Rojas-Vargas, AC, 2008)
" Two important determinants in this environment are hypoxia and lactic acidosis."	3.74	The genomic analysis of lactic acidosis and acidosis response in human cancers. ( Chen, JL; Chi, JT; Dewhirst, M; Lucas, JE; Mori, S; Nevins, J; Schroeder, T; West, M; Wu, J, 2008)
" Tissue glucose uptake and cardiovascular characteristics were measured in the short-horned sculpin, Myoxocephalus scorpius, a species exhibiting low blood glucose levels, during normoxia and hypoxia to assess the role of adenosine receptors in the control of glucose uptake and anaerobic metabolism."	3.74	The impact of hypoxia on in vivo glucose uptake in a hypoglycemic fish, Myoxocephalus scorpius. ( Driedzic, WR; MacCormack, TJ, 2007)
" Our results demonstrate that 1) males sustain isometric force production (F) longer than females under hyperoxia (P O2 = 640 mmHg) with exogenous glucose present; 2) contractility is not maintained under moderate (P O2 = 130 mmHg) or severe hypoxia (P O2 = 10-20 mmHg) with glucose in either sex; however, following reoxygenation, F is higher in females compared with males; and 3) female tissue has higher lactate levels, net lactate efflux, and lactate dehydrogenase activity than males, whereas males have higher glycogen, citrate synthase, and beta-hydroxy acyl-CoA dehydrogenase activities, and greater inotropic responses to exogenous glucose and octanoate."	3.74	Sex differences in energy metabolism and performance of teleost cardiac tissue. ( Battiprolu, PK; Harmon, KJ; Rodnick, KJ, 2007)
" Taurine may have been released by the tissues as a protective mechanism against hypoxia-induced inflammation, or in an attempt to maintain osmotic balance."	3.74	Taurine as a marker for foetal wellbeing? ( de Boo, HA; Harding, JE, 2007)
" A randomized controlled study was designed to examine the dose-response effect of dobutamine (5-20 microg x kg(-1) x min(-1)) on systemic and regional circulations and oxygen metabolism in a neonatal swine model of hypoxia/reoxygenation."	3.74	The hemodynamic effects of dobutamine during reoxygenation after hypoxia: a dose-response study in newborn pigs. ( Abozaid, S; Al-Salam, Z; Bigam, D; Cheung, PY; Johnson, S, 2007)
" Extracellular pH defense against lactic acidosis was estimated from changes (Delta) in lactic acid ([La]), [HCO3-], pH and PCO2 in plasma, which equilibrates with interstitial fluid."	3.74	Extracellular pH defense against lactic acid in untrained and trained altitude residents. ( Böning, D; Coy, L; Mora, M; Reyes, O; Rojas, J; Serrato, M, 2008)
"We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model."	3.73	Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005)
"Acute hypoxia increases cerebral lactate and alanine in NG chick embryos; these increases are reduced by pre-exposure to substrate deprivation and chronic hypoxia."	3.73	Growth restriction and the cerebral metabolic response to acute hypoxia of chick embryos in-ovo: a proton magnetic resonance spectroscopy study. ( Cady, EB; Dixon, JC; Peebles, DM; Priest, AN; Thornton, JS, 2005)
" This effect disappeared, however, when hypoxia was combined with acidosis obtained by 24 mM lactic acid."	3.73	Force development at elevated [Mg2+]o and [K+]o in myocardium from the freshwater turtle (Trachemys scripta) and influence of factors associated with hibernation. ( Gesser, H, 2006)
" To gain a better understanding of the mechanisms responsible for oxygen and nutrient sensing in chondrocytes, we investigated the effects of hypoxic stimulation induced by cobalt chloride treatment (a hypoxia-mimetic) on glucose uptake and lactate production in chondrocytes."	3.73	Regulation of 2-deoxy-D-glucose transport, lactate metabolism, and MMP-2 secretion by the hypoxia mimetic cobalt chloride in articular chondrocytes. ( Mobasheri, A; Platt, N; Shakibaei, M; Thorpe, C, 2006)
" Incubation at hypoxia resulted in increased lactate concentrations, whereas ATP, glucose, and glycogen concentrations were decreased, especially in the mid media, where concentrations of these metabolites were close to zero."	3.72	Mapping of ATP, glucose, glycogen, and lactate concentrations within the arterial wall. ( Björnheden, T; Bondjers, G; Evaldsson, M; Leppänen, O; Levin, M; Wiklund, O, 2003)
" We conclude that caiman osteoderms sequester lactate during lactic acidosis and that the time course is fast enough to have benefit to these animals following normal anaerobic burst activity."	3.72	Lactate sequestration by osteoderms of the broad-nose caiman, Caiman latirostris, following capture and forced submergence. ( Abe, AS; Andrade, DV; Jackson, DC, 2003)
" The addition of the glucose transporter inhibitor cytochalasin B caused hypoxic hearts to fail early, and hearts perfused with a glucose analogue, 2-deoxyglucose (2-DG), increased glucose uptake 3-fold under hypoxia."	3.72	The regulation and importance of glucose uptake in the isolated Atlantic cod heart: rate-limiting steps and effects of hypoxia. ( Clow, KA; Driedzic, WR; MacCormack, TJ; Rodnick, KJ, 2004)
" We hypothesized that ephedrine and phenylephrine, administered for maternal hypotension following fetal hypoxaemia, are equal in respect of fetal outcome."	3.72	Effects of ephedrine and phenylephrine on uterine and placental circulations and fetal outcome following fetal hypoxaemia and epidural-induced hypotension in a sheep model. ( Alahuhta, S; Erkinaro, T; Kavasmaa, T; Mäkikallio, K; Räsänen, J, 2004)
" Hypoxia induced an immediate and significant elevation in the intraperitoneal lactate/pyruvate ratio to 446+/-137% of the baseline values, and glycerol subsequently increased during reoxygenation to 389+/-109%."	3.71	Intraperitoneal microdialysis for detection of splanchnic metabolic disorders. ( Bahlmann, L; Bruch, HP; Gliemroth, J; Heringlake, M; Klaus, S, 2002)
" Under conditions of acute hypoxia induced by breathing carbon monoxide at 660 ppm, the apparent glycolytic rate was 0."	3.71	Effect of changing tumor oxygenation on glycolytic metabolism in a murine C3H mammary carcinoma assessed by in vivo nuclear magnetic resonance spectroscopy. ( Bentzen, L; Daugaard, P; Horsman, MR; Maxwell, RJ; Nielsen, FU; Overgaard, J; Stødkilde-Jørgensen, H, 2001)
" Hyperlactatemia with L/P ratio elevation and lactic acidosis is likely to be associated with inadequate tissue perfusion."	3.70	Time-pattern of lactate and lactate to pyruvate ratio in the first 24 hours of intensive care emergency admissions. ( Kari, A; Ruokonen, E; Suistomaa, M; Takala, J, 2000)
"We investigated the metabolic effects of buffering agents alpha-amino-4-imidazole-propionic acid (Histidine), N, N-bis(2-hydroxyethyl)glycine (bicine), N, N-bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES) on anaerobic energy production (via glycolysis) and conservation of key regulatory enzyme activity, and phosphofructokinase (PFK) throughout prolonged hypothermic hypoxia in porcine hearts."	3.70	Conservation of phosphorylation state of cardiac phosphofructokinase during in vitro hypothermic hypoxia. ( Churchill, TA; Kneteman, NM; Pulis, RP; Wu, BM, 2000)
" To study the effect of acute moderate hypoxia on plasma lactic acid (LA) and lactic dehydrogenase (LDH) content in pilots."	3.70	[Effects of acute hypoxia on plasma lactic acid and lactic dehydrogenase content in pilots]. ( Li, WB; Liu, Y; Qin, SZ, 2000)
"This study examines the neonatal response to graded hypoxia and determines the arterial PO2 (PaO2) threshold for oxygen-restricted metabolism as confirmed by the development of lactic acidosis and altered oxygen handling."	3.69	Blood lactate and acid-base balance in graded neonatal hypoxia: evidence for oxygen-restricted metabolism. ( Torrance, SM; Wittnich, C, 1994)
"Isovolumetric rat hearts (37 degrees C) were treated with 1 microM (apri 1) or 30 microM (apri 30) aprikalim, or preconditioned with either 10 min of hypoxia (N2PC) or 5 min of ischaemia followed by 5 min of perfusion (IPC5) or 10 min of ischaemia followed by 3 min of perfusion (IPC10)."	3.69	Comparison of effects of aprikalim and of hypoxic and ischaemic preconditioning on extracellular potassium accumulation, metabolism, and functional recovery of the globally ischaemic rat heart. ( Diacono, J; Feuvray, D; Guo, AC, 1994)
"The present study was designed to determine whether lactate changes the critical pH point at which the recovery of rat population spike is inhibited following glucose-oxygen deprivation and second, which degree of lactic acidosis is similar to the effect of CO2 acidosis."	3.69	Effect of lactic and CO2 acidosis on neuronal function following glucose-oxygen deprivation in rat hippocampal slices. ( Kemmotsu, O; Morimoto, Y, 1994)
"The goal of this study was to evaluate whether sodium bicarbonate might be a useful form of therapy for hypoxic L-lactic acidosis; our aim was to determine if alkali could extend the time of survival in this setting."	3.69	Alkali therapy extends the period of survival during hypoxia: studies in rats. ( Cheema-Dhadli, S; Chen, CB; Halperin, FA; Halperin, ML, 1996)
"The influence of systemic hypoxia on lactate and adenosine output from isolated constant-flow-perfused gracilis muscle was determined in anesthetized dogs."	3.69	Intracellular lactate controls adenosine output from dog gracilis muscle during moderate systemic hypoxia. ( Ballard, HJ; Mo, FM, 1997)
"In isovolumically perfused Langendorff heart preparations of guinea pigs adenosine-depending on the experimental protocol-more or less could prevent the hypoxia-induced decrease in myocardial adenosine triphosphate [ATP], creatine phosphate [CP], glycogen and increase in lactate, i."	3.69	On the cardioprotective effect of adenosine. ( Kovács, P; Nosztray, K; Szabó, JZ; Szegi, J; Szentmiklósi, AJ; Ujfalusi, A; Varga, E, 1996)
"The role of inhibition of the CPT enzymes responsible for accumulation of long chain acylcarnitines (LCAC) during hypoxia in the proximal tubule has not been previously examined."	3.69	Carnitine palmitoyl-transferase enzyme inhibition protects proximal tubules during hypoxia. ( Portilla, D, 1997)
"Experiments are described in which a rat hippocampal slice preparation was used along with the metabolic glial inhibitor, fluorocitrate (FC), to investigate the role of glial-made lactate and its shuttling to neurons in posthypoxia recovery of synaptic function."	3.69	Glia are the main source of lactate utilized by neurons for recovery of function posthypoxia. ( Miller, JJ; Payne, RS; Rigor, BM; Schurr, A, 1997)
" The application of cyanide (to mimic hypoxia) produced a fall of the concentration of phosphocreatine ([PCr]) and a rise of those of inorganic phosphate ([Pi]) and sugar phosphates."	3.68	Relationship between intracellular pH and metabolite concentrations during metabolic inhibition in isolated ferret heart. ( Bauer, CJ; Donoso, P; Eisner, DA; Smith, GL, 1993)
"Flux through the adenosine production and degradation pathways is transiently increased during hypoxia."	3.68	Interstitial purine metabolites and lactate during regional myocardial hypoxia. ( Downey, HF; Van Wylen, DG; Williams, AG, 1993)
"We tested the hypotheses that in newborn piglets indomethacin (Indo) pretreatment blunts the hyperemic brain blood flow (BF) and alters the cerebral metabolic responses to hypoxia and that these responses are dose dependent."	3.68	Effects of indomethacin on brain blood flow and cerebral metabolism in hypoxic newborn piglets. ( Coyle, MG; Oh, W; Stonestreet, BS, 1993)
"Previous studies in this laboratory showed that hypoxia and anoxia enhance the susceptibility of hepatocytes to tert-butylhydroperoxide (TBH)-induced oxidative injury."	3.68	Postanoxic oxidative injury in rat hepatocytes: lactate-dependent protection against tert-butylhydroperoxide. ( Aw, TY; Jones, DP; Kowalski, DP; Park, Y, 1992)
"Lactic acid, the end metabolic product of anaerobic glycolysis is probably the mediator of the hypoxia induced vasodilation on retinal arterioles."	3.68	[Metabolic factors of vasomotor regulation of the inner retina]. ( Brazitikos, PD; Munoz, JL; Pournaras, CJ; Tsacopoulos, M, 1992)
"We tested whether digoxin would limit tissue hypoxia during severe anemia by improving peripheral O2 distribution or decreasing O2 demands."	3.68	Oxygen transport during anemic hypoxia in pigs: effects of digoxin on metabolism. ( Hendler, R; Lister, G; Saltiel, A; Sanfilippo, DJ, 1992)
" We hypothesized that the lactic acidosis associated with prolonged systemic hypoxemia might mediate the adaptation of the hypoxemic inhibition of FBM."	3.68	Vascular lactic acid infusions do not alter the incidence of fetal breathing movements or their inhibition by acute hypoxemia. ( Bissonnette, JM; Hohimer, AR, 1991)
"In the rat vas deferens (preloaded with 3H-noradrenaline, catechol-O-methyl transferase inhibited, calcium-free solution) ouabain, glucose deprivation or the combination of hypoxia plus presence of lactate were found to induce a carrier-mediated (desipramine-sensitive) outward transport of the 3H-amine."	3.68	The energy requirements for the basal efflux of 3H-noradrenaline from sympathetically innervated organs. ( Russ, H; Schömig, E; Trendelenburg, U, 1991)
" To study this problem, acute isocapnic metabolic acidosis was induced by HCl or lactic acid infusions in rats, and recovery from acidosis was accomplished by NaHCO3 infusion."	3.68	Brain pH in acute isocapnic metabolic acidosis and hypoxia: a 31P-nuclear magnetic resonance study. ( Adler, S; Ho, C; Simplaceanu, V, 1990)
"88 mM Amytal (amobarbital), hypoxia (95% N2-5% CO2), or 12 microM adenosine in the presence and absence of 2."	3.67	Relationship of myocardial metabolism and coronary flow: dependence on extracellular calcium. ( Erecińska, M; Rumsey, WL; Wilson, DF, 1987)
" We studied the effects of carbicarb in an animal preparation of hypoxic lactic acidosis (HLA)."	3.67	Improved hemodynamic function during hypoxia with Carbicarb, a new agent for the management of acidosis. ( Arieff, AI; Bersin, RM, 1988)
"The relationships between the concentrations of glycogen, glucose, lactate, adenosine triphosphate (ATP) and hypoxanthine in the brain tissue, and the hypoxanthine and lactate concentration in cerebrospinal fluid and blood were examined after exposure of rats to hypoxia."	3.67	Concentration of hypoxanthine in both cerebrospinal fluid and brain tissue increases under intensive hypoxia only. ( Gross, J; Lun, A; Pohle, R; Siggel, H, 1988)
"The role of lactic acidosis of progressive brain hypoxia (PBH) as both a central chemoreceptor stimulant and a general respiratory depressant was assessed by preventing lactate formation both locally and globally with dichloroacetate (DCA)."	3.67	Role of brain lactic acidosis in hypoxic depression of respiration. ( Edelman, NH; Neubauer, JA; Simone, A, 1988)
"To determine the suitability of plasma hypoxanthine as a marker of tissue hypoxia, we studied the relationship of arterial plasma hypoxanthine and blood lactate concentrations to the cumulative O2 deficit during hypoxemia and low cardiac output (hypoxic and stagnant hypoxia, respectively)."	3.67	Hypoxanthine and lactate concentrations in lambs during hypoxic and stagnant hypoxia. ( Kurzner, S; Lister, G; Moss, M; Razlog, Y, 1988)
"Hypoxic lactic acidosis (HLA) was induced in dogs by ventilating them with a hypoxic gas mixture of 8% O2-92% N2."	3.67	Pathophysiology of type A hypoxic lactic acidosis in dogs. ( Arieff, AI; Graf, H, 1987)
"To test the hypothesis that adenosine is required to mediate the coronary vasodilative response to acute hypoxia haemodynamic indices, regional myocardial blood flow, and oxygen and lactate metabolism were measured in nine closed chest anaesthetised domestic swine at control, after 3-5 min of 100% nitrogen inhalation, at second control, and after 3-5 min of 100% nitrogen inhalation plus adenosine deaminase infusion in the left anterior descending coronary artery."	3.67	Role of adenosine in mediating the coronary vasodilative response to acute hypoxia. ( Gewirtz, H; Most, AS; Olsson, RA, 1987)
" Reduced ATP and phosphocreatine content, intracellular acidosis related to hypercapnia, increased muscle lactate without alterations of the muscle lactate concentration gradient were observed in the skeletal muscle of the hypercapnic-hypoxemic COPD patients studied, in which group no correlation was found between hypoxia and energy or lactate metabolism parameters."	3.67	Skeletal muscle energetics, acid-base equilibrium and lactate metabolism in patients with severe hypercapnia and hypoxemia. ( Coffrini, E; Del Canale, S; Fiaccadori, E; Guariglia, A; Ronda, N; Vitali, P, 1987)
"Experimental factors implicated in the pathogenesis of halothane hepatotoxicity in the phenobarbital-hypoxia rat model were examined for direct effects on the energy status of isolated rat liver cells in vitro."	3.67	Energy deficits in hepatocytes isolated from phenobarbital-treated or fasted rats and briefly exposed to halothane and hypoxia in vitro. ( Albrecht, RF; Becker, GL; Hensel, P; Holland, AD; Miletich, DJ, 1986)
"The effect of hypoxia on the elimination of omeprazole, a potent inhibitor of gastric acid secretion, was studied in the isolated perfused rat liver."	3.67	Effect of hypoxia on oxidative and reductive pathways of omeprazole metabolism by the isolated perfused rat liver. ( Jones, DB; Mihaly, GW; Morgan, DJ; Smallwood, RA; Webster, LK, 1985)
"In mice, changes of body temperature and concentration of lactic acid in the blood were studied after three modes of barochamber hypoxia (altitude 8000 m) at the temperatures +10, +20 and +36 degrees C."	3.67	[Effect of short-term hypoxia on body temperature and lactic acid in the blood of the mouse]. ( Pisarenko, SN; Sepisheva, AS; Slonim, AD, 1985)
"The possibility of detecting past hypoxia during the first 2 h after birth by means of blood analyses of hypoxanthine, lactate, base deficit, and pH was investigated in six infants with a 1 min Apgar score of less than or equal to 4."	3.66	Hypoxanthine as a test of perinatal hypoxia as compared to lactate, base deficit, and pH. ( Bratteby, LE; Swanström, S, 1982)
" Alterations in coronary flow were induced by hypoxia, amobarbital (Amytal) infusion, increase in work load of the heart, and adenosine infusion."	3.66	Role of mitochondrial oxidative phosphorylation in regulation of coronary blood flow. ( Erecińska, M; Nishiki, K; Nuutinen, EM; Wilson, DF, 1982)
" A diagnosis of idiopathic lactic acidosis was established when the arterial blood pH was found to be 6."	3.64	THE CLINICAL SIGNIFICANCE OF ELEVATED BLOOD LACTATE. ( PHILLIPSON, EA; SPROULE, BJ, 1965)
" Future studies should focus on potential dose-response effects and the involved mechanisms."	3.30	Repeated Short-Term Bouts of Hyperoxia Improve Aerobic Performance in Acute Hypoxia. ( Dünnwald, T; Faulhaber, M; Gatterer, H; Kennedy, MD; Menz, V; Rausch, LK; Schneider, S; Schobersberger, W, 2023)
"Currently, hypothermia is the only approved clinical treatment available for HIE."	3.01	Exogenous lactate administration: A potential novel therapeutic approach for neonatal hypoxia-ischemia. ( Deng, Q; Duan, R; Liu, TC; Wu, C; Yang, L, 2023)
"Lactate acidosis is often observed in the tumor microenvironment (TME) of solid tumors."	3.01	Lactate acidosis and simultaneous recruitment of TGF-β leads to alter plasticity of hypoxic cancer cells in tumor microenvironment. ( Arora, MK; Banerjee, S; Kaithwas, G; Mishra, SS; Rastogi, S; Ravichandiran, V; Roy, S; Singh, L, 2023)
"Hypoxemia is readily detectable by assessing SpO2 levels, and these are important in optimizing COVID-19 patient management."	3.01	Longitudinal Monitoring of Lactate in Hospitalized and Ambulatory COVID-19 Patients. ( Gabor, J; Kieu Linh, LT; Kreidenweiss, A; Kremsner, PG; Krishna, S; Velavan, TP, 2021)
"Compared to normoxemia, hypoxemia did not significantly modify the resting concentrations of TBARS and RAA, and did not affect the consumption of ascorbic acid after 60% MVC but suppressed the post-exercise TBARS increase."	2.70	Acute hypoxemia does not increase the oxidative stress in resting and contracting muscle in humans. ( Dousset, E; Faucher, M; Jammes, Y; Steinberg, JG, 2002)
"Glycogenolysis was lower with DCA, resulting in reduced lactate concentration ([lactate]), despite similar phosphorylase a mole fractions and posttransformational regulators."	2.69	Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia. ( Heigenhauser, GJ; Hollidge-Horvat, MG; Hultman, E; Jones, NL; Matsos, MP; Parolin, ML; Spriet, LL, 2000)
"1."	2.68	The effect of altitude hypoxia on glucose homeostasis in men. ( Dela, F; Galbo, H; Hansen, JM; Larsen, JJ; Olsen, NV, 1997)
"Global metabolism of cancers exhibits a peculiar phenotype that is lactate acidosis (high lactate with acidic pH) in tumor microenvironment."	2.61	Lactate as a signaling molecule: Journey from dead end product of glycolysis to tumor survival. ( Chhonker, SK; Koiri, RK; Mehrotra, A; Naik, RA; Rawat, D; Trigun, SK, 2019)
"Early-onset hyperlactatemia is that which develops in the operating room or very early following intensive care unit (ICU) admission."	2.55	Hyperlactatemia and Cardiac Surgery. ( Minton, J; Sidebotham, DA, 2017)
"Although interest in lactate for cancer development only appeared recently, pharmacological molecules blocking its metabolism are already in phase I/II clinical trials."	2.53	Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters. ( Marchiq, I; Pouysségur, J, 2016)
"Inflammation is an important component of normal responses to infection and injury."	2.49	Metabolomics--a novel window into inflammatory disease. ( Fitzpatrick, M; Young, SP, 2013)
"Before heating, locally advanced cervical cancers are mostly hypoxic, acidic, exhibit substrate and energy deprivation and show lactate accumulation, which is spatially and temporally heterogeneous."	2.48	Blood flow and associated pathophysiology of uterine cervix cancers: characterisation and relevance for localised hyperthermia. ( Kelleher, DK; Vaupel, PW, 2012)
"DC have been shown to infiltrate many tumors but both, circulating and tumor-infiltrating DC from cancer patients, appear to be phenotypically and functionally defective."	2.44	Tumor-induced modulation of dendritic cell function. ( Gottfried, E; Kreutz, M; Mackensen, A, 2008)
"During prolonged anoxia at low temperature, freshwater turtles develop high plasma concentrations of both lactate and calcium."	2.42	Surviving extreme lactic acidosis: the role of calcium lactate formation in the anoxic turtle. ( Jackson, DC, 2004)
"This is also true for patients in septic shock after plasma volume expansion."	2.39	[Is infection and septic shock caused by a global oxygen deficiency? An overview in 2 parts. 1: Infection and correlation between DO2 and VO2]. ( Ensinger, H; Georgieff, M, 1996)
"Under high-altitude hypoxia environment, the body is more prone to fatigue, which occurs in both peripheral muscles and the central nervous system (CNS)."	1.91	Monocarboxylate transporter-dependent mechanism is involved in the adaptability of the body to exercise-induced fatigue under high-altitude hypoxia environment. ( Gao, C; Li, Y; Pei, W; Yang, B, 2023)
"This study demonstrates that acute high altitude hypoxia upregulated the lactic acid/amino acid-pyruvate-TCA pathways and fatty acid oxidation, but downregulated glycolysis in the liver of mice."	1.91	Energy metabolic mechanisms for high altitude sickness: Downregulation of glycolysis and upregulation of the lactic acid/amino acid-pyruvate-TCA pathways and fatty acid oxidation. ( Jiang, C; Li, Y; Liao, N; Liu, G; Shang, X; Shao, D; Shi, J; Xu, F; Yin, D, 2023)
"Solid tumors have developed robust ferroptosis resistance."	1.91	HIF-1α drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1. ( Guan, Q; Qin, C; Qu, S; Su, W; Wang, Y; Wei, X; Xiang, J; Yang, Z; Yao, B; Zen, K; Zhao, D; Zhou, J, 2023)
" In our study, patients were administered a daily dosage of 2 × 600 mg of diosmin for 3 months, and we evaluated several factors associated with oxygen management, angiogenesis, and inflammation using biochemical assays."	1.91	Effect of Diosmin on Selected Parameters of Oxygen Homeostasis. ( Dresler, S; Feldo, M; Płachno, BJ; Samborski, D; Sowa, I; Sowa, P; Wójciak, M, 2023)
"During intervertebral disc degeneration (IVDD), due to endplate calcification, diminished oxygen and nutrient concentrations and accumulated lactate are present in the microenvironment of the nucleus pulposus (NP)."	1.72	Monocarboxylate transporter 1-mediated lactate accumulation promotes nucleus pulposus degeneration under hypoxia in a 3D multilayered nucleus pulposus degeneration model. ( Bit, A; Hsieh, MK; Hu, YJ; Lai, PL; Wang, CY, 2022)
"Hypoxia is a common concern in shrimp aquaculture, affecting growth and survival."	1.72	Changes in metabolic profiling of whiteleg shrimp (Penaeus vannamei) under hypoxic stress. ( Alfaro, AC; Bayot, B; Nguyen, TV; Rodríguez, J; Sonnenholzner, S, 2022)
"Gestational hypoxemia is often associated with reduced birth weight, yet how hypoxemia controls uteroplacental nutrient metabolism and supply to the fetus is unclear."	1.62	Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia. ( Brown, LD; Jones, AK; Julian, CG; Limesand, SW; Lorca, RA; Moore, LG; Rozance, PJ; Wesolowski, SR, 2021)
"NIP2;1 expression is limited to the "anoxia core" region of the root stele under normal growth conditions, but shows substantial induction (up to 1,000-fold by 2-4 h of hypoxia) by low oxygen stress, and accumulation in all root tissues."	1.62	Aquaporin family lactic acid channel NIP2;1 promotes plant survival under low oxygen stress in Arabidopsis. ( Beamer, ZG; Choi, WG; Lokdarshi, A; Roberts, DM; Routray, P; Spangler, MK, 2021)
"Melanoma is the most lethal of all skin-related cancers with incidences continuously rising."	1.62	In Vitro Evaluation of CD276-CAR NK-92 Functionality, Migration and Invasion Potential in the Presence of Immune Inhibitory Factors of the Tumor Microenvironment. ( Baden, C; Chan, KC; Grote, S; Handgretinger, R; Mezger, M; Schleicher, S; Ureña-Bailén, G, 2021)
"Hypoxia and inflammation are hallmarks of critical illness, related to multiple organ failure."	1.62	Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males. ( Bergmans, DCJJ; Driessen, RGH; Gerretsen, J; Kiers, D; Kox, M; Pickkers, P; Schalkwijk, CG; Scheijen, JLJM; van Bussel, BCT; van de Poll, MCG; van der Horst, ICC, 2021)
"Hypovolemia was induced and maintained for 20 min by removal of 50% of the total blood volume; thereafter, the animals were retransfused."	1.56	Altered Cerebral Blood Flow and Potential Neuroprotective Effect of Human Relaxin-2 (Serelaxin) During Hypoxia or Severe Hypovolemia in a Sheep Model. ( Bischoff, SJ; Irintchev, A; Lehmann, T; Lemke, C; Nistor, M; Schiffner, R; Schmidt, M, 2020)
"In solid tumors, hypoxia can trigger aberrant expression of transcription factors and genes, resulting in abnormal biological functions such as altered energetic pathways in cancer cells."	1.56	Computational modeling to determine key regulators of hypoxia effects on the lactate production in the glycolysis pathway. ( Hashemzadeh, S; Omidi, Y; Rafii-Tabar, H; Shahmorad, S, 2020)
"IDH1 mutant gliomas have distinct metabolic and microenvironment characteristics compared with wild type gliomas."	1.51	Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI. ( Chakhoyan, A; Cloughesy, TF; Ellingson, BM; Everson, RG; Lai, A; Liau, LM; Mareninov, S; Nathanson, DA; Nghiemphu, PL; Pope, WB; Prins, RM; Raymond, C; Salamon, N; Yao, J; Yong, WH, 2019)
"Ischemia was followed by a significant increase in muscle myeloperoxidase activity, as well as interleukin-6 and thiobarbituric acid reactive substances species levels."	1.48	N-acetylcysteine effects on a murine model of chronic critical limb ischemia. ( Constantino, L; da Silva, LA; Dal-Pizzol, F; Dall'Igna, DM; de Medeiros, WA; Dos Santos Cardoso, J; Manfredini, A; Michels, M; Ritter, C; Scaini, G; Streck, EL; Vuolo, F, 2018)
"Cholesteatoma has attracted many studies seeking to uncover its nature and the pathogenesis of related diseases."	1.48	Comparison of changes in mitochondrial bioenergetics between keratinocytes in human external auditory canal skin and cholesteatomas from normoxia to hypoxia. ( Chen, HC; Chen, HK; Chen, YT; Kuo, CY; Lee, JT; Lin, YC; Lin, YY; Shih, CP; Wang, CH, 2018)
"We suspect that exercise-induced hypoxemia occurring during running could be at the origin of the RBC rheological behavior differences with cycling."	1.48	Eryptosis and hemorheological responses to maximal exercise in athletes: Comparison between running and cycling. ( Connes, P; Fort, R; Germain, M; Guillot, N; Hancco, I; Joly, P; Lavorel, L; Nader, E; Renoux, C; Stauffer, E, 2018)
"Hypoxemia is one of the most common pathological processes in various clinical diseases."	1.48	High-performance reoxygenation from PLGA-PEG/PFOB emulsions: a feedback relationship between ROS and HIF-1α. ( He, D; Huang, G; Li, N; Shen, X; Wang, J; Wang, R; Zhu, J, 2018)
"Unearthing embryology-like processes in tumors may allow us to control organ-like tumor features such as tissue repair and revascularization and treat intratumoral heterogeneity."	1.46	Metabolic origins of spatial organization in the tumor microenvironment. ( Akkari, L; Carmona-Fontaine, C; Deforet, M; Joyce, JA; Thompson, CB; Xavier, JB, 2017)
"Recent research suggest that anoxia-tolerant fish transfer extracellular nitrite into the tissues, where it is used for nitric oxide (NO) generation, iron-nitrosylation, and S-nitrosation of proteins, as part of the cytoprotective response toward prolonged hypoxia and subsequent reoxygenation."	1.43	Nitric oxide availability in deeply hypoxic crucian carp: acute and chronic changes and utilization of ambient nitrite reservoirs. ( Gerber, L; Hansen, MN; Jensen, FB, 2016)
"After 1 week of anoxia, a major part of the glycogen stores was mobilized in liver (79."	1.43	Glycogen dynamics of crucian carp (Carassius carassius) in prolonged anoxia. ( Haverinen, J; Vornanen, M, 2016)
"Exercise-induced arterial hypoxemia (EIAH) is often found in endurance-trained subjects at high exercise intensity."	1.42	Exercise effects on erythrocyte deformability in exercise-induced arterial hypoxemia. ( Alis, R; Blesa, JR; Ferioli, D; La Torre, A; Romagnoli, M; Sanchis-Gomar, F, 2015)
"With intermittent anoxia, the pattern of substrate effects on the NAP changed markedly so that low concentrations of fructose became able to support neurophysiologic activity but not high concentrations of glucose."	1.42	Anoxia-induced changes in optimal substrate for peripheral nerve. ( Stecker, MM; Stevenson, MR, 2015)
"BxPC-3 pancreatic cancer cells were cultured under hypoxic conditions and treated with or without the nanoparticles."	1.42	PLGA/poloxamer nanoparticles loaded with EPAS1 siRNA for the treatment of pancreatic cancer in vitro and in vivo. ( Fang, W; Li, K; Li, L; Pan, X; Sun, Y; Zhao, Z; Zhu, Q; Zhu, Y; Zuo, J, 2015)
"High uric acid (UA) has been found to be correlated with renal dysfunction in some experimental and clinical studies; however, the study of the dynamic correlation between AKI and UA in severe burns is still lacking."	1.42	Elevated serum uric acid after injury correlates with the early acute kidney in severe burns. ( Hu, X; Liang, J; Zhang, P; Zhi, L, 2015)
"Acute mountain sickness is caused by sub-acute hypoxia in healthy individuals going rapidly to altitude."	1.39	The antioxidative effect of a novel free radical scavenger 4'-hydroxyl-2-substituted phenylnitronyl nitroxide in acute high-altitude hypoxia mice. ( Fan, PC; Jia, ZP; Jing, LL; Li, L; Ma, HP, 2013)
"While respiratory alkalosis occurred in patients with better preservation of FEV1, respiratory acidosis was observed with more severe airway obstruction, as was increased lactate in the majority of patients, independent of PaO(2) and PaCO(2) levels."	1.39	Acid-base patterns in acute severe asthma. ( Adrogué, HJ; Gonzalez, S; Menga, G; Raimondi, GA; Zaltsman, J, 2013)
"We have shown earlier that breast cancer cells secrete higher levels of interleukin-6 (IL-6) under hypoxia, leading to the recruitment of hMSCs towards hypoxic tumor cells."	1.38	Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment. ( Ackerstaff, E; Banerjee, D; Glod, JW; Koutcher, JA; Patel, BB; Rattigan, YI; Sukenick, G, 2012)
"Only 65% of patients with septic shock had hyperlactataemia at the onset of shock and 76% of these also had a high lactate/pyruvate ratio."	1.38	Lactate/pyruvate ratio as a marker of tissue hypoxia in circulatory and septic shock. ( Bruzzi de Carvahlo, F; Cotton, F; De Backer, D; Orellano-Jimenez, C; Rimachi, R; Vincent, JL, 2012)
"However, EPAOC after 36 h of anoxia could not account for RMR being maintained."	1.37	Anoxic survival of the Pacific hagfish (Eptatretus stoutii). ( Cox, GK; Farrell, AP; Richards, JG; Sandblom, E, 2011)
"Histamine was released during hypoxia and reoxygenation and also reperfusion, as was tryptase β, and high concentrations of adenosine (>1 µmol litre⁻¹, hypoxia group) and inosine (> 7 µmol litre⁻¹, ischaemia group) were measured in effluent (P < 0."	1.37	Shedding of the coronary endothelial glycocalyx: effects of hypoxia/reoxygenation vs ischaemia/reperfusion. ( Annecke, T; Becker, BF; Conzen, P; Fischer, J; Hartmann, H; Rehm, M; Sommerhoff, CP; Tschoep, J, 2011)
"Chuvash polycythemia (CP) is an autosomal recessive human disorder in which the regulatory degradation of HIF is impaired, resulting in elevated levels of HIF at normal oxygen tensions."	1.36	Regulation of human metabolism by hypoxia-inducible factor. ( Cheeseman, J; Clarke, K; Constantin-Teodosiu, D; Dorrington, KL; Edwards, LM; Emmanuel, Y; Formenti, F; Frayn, KN; Greenhaff, PL; Humphreys, SM; Karpe, F; Lappin, TR; McMullin, MF; McNamara, CJ; Mills, W; Murphy, JA; O'Connor, DF; Percy, MJ; Ratcliffe, PJ; Robbins, PA; Smith, TG; Treacy, M, 2010)
"Insulin sensitivity was assessed using the euglycemic clamp before and after the exposures."	1.35	Effects of acute intermittent hypercapnic hypoxia on insulin sensitivity in piglets using euglycemic clamp. ( Aouad, LJ; Tam, K; Waters, KA, 2008)
"Nutritional interventions for intrauterine growth restriction (IUGR) have raised concerns for fetal toxicity, the mechanisms of which are unknown."	1.35	Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction. ( Barry, JS; Brown, LD; Hay, WW; Limesand, SW; Rozance, PJ, 2009)
"SRBD patients had obstructive sleep apnea syndrome with or without sleep-related hypoventilation/hypoxemic conditions."	1.35	Nocturnal hypoxia and arterial lactate levels in sleep-related breathing disorders. ( Erbaycu, AE; Guclu, SZ; Kirakli, C; Taymaz, Z; Tuksavul, F; Ucar, ZZ, 2009)
"During septic shock, muscle produces lactate by way of an exaggerated NaK-adenosine triphosphatase (ATPase)-stimulated aerobic glycolysis associated with epinephrine stimulation possibly through beta2 adrenoreceptor involvement."	1.35	Increased aerobic glycolysis through beta2 stimulation is a common mechanism involved in lactate formation during shock states. ( Desebbe, O; Gibot, S; Levy, B; Montemont, C, 2008)
"Moreover, the stimulatory effect of anoxia on glycolytic flux was inversely correlated to the relative reliance on aerobic glycolysis."	1.35	Aerobic glycolysis in cancers: implications for the usability of oxygen-responsive genes and fluorodeoxyglucose-PET as markers of tissue hypoxia. ( Busk, M; Bussink, J; Horsman, MR; Kristjansen, PE; Overgaard, J; van der Kogel, AJ, 2008)
"For each measurement, the more anoxia-tolerant species (painted turtle, Chrysemys picta; snapping turtle, Chelydra serpentina) had higher values than the less anoxia-tolerant species (musk turtle, Sternotherus odoratus; map turtle, Graptemys geographica; red-eared slider, Trachemys scripta)."	1.34	Comparative shell buffering properties correlate with anoxia tolerance in freshwater turtles. ( Asare, VS; Gall, JM; Jackson, DC; Reese, SA; Taylor, SE; Villarnovo, D, 2007)
"Muscle lactate formation in endotoxic shock was further inhibited by intravenous infusion of ICI-118551 or dichloroacetate (DCA), an activator of pyruvate dehydrogenase (DCA) and their combination."	1.34	Myocardial lactate deprivation is associated with decreased cardiovascular performance, decreased myocardial energetics, and early death in endotoxic shock. ( Gibot, S; Lacolley, P; Lecompte, T; Levy, B; Mallie, JP; Mansart, A; Montemont, C; Regnault, V, 2007)
"Muscles utilize glycogen during anoxia more at warmer temperatures."	1.34	Effects of temperature on anoxic submergence: skeletal buffering, lactate distribution, and glycogen utilization in the turtle, Trachemys scripta. ( Jackson, DC; Warren, DE, 2007)
"We assessed the anoxia tolerance of A."	1.34	Extreme anoxia tolerance in embryos of the annual killifish Austrofundulus limnaeus: insights from a metabolomics analysis. ( Fan, TW; Higashi, R; Lopez, JP; Podrabsky, JE; Somero, GN, 2007)
" The fatigue task altered the dose-response relationship to intramuscular acidic saline injections."	1.34	Muscle fatigue increases the probability of developing hyperalgesia in mice. ( Lisi, TL; Moore, SA; Sluka, KA; Yokoyama, T, 2007)
"After a stabilization period, prolonged hypoxemia (FiO(2): 0."	1.33	Excitatory amino acid release and electrocortical brain activity after hypoxemia in near-term lambs. ( Hopman, J; Ruitenbeek, W; van de Bor, M; van Os, S, 2006)
"Neonatal anoxia was induced by placing 2-day-old rat pups into a glass chamber with 100% N(2) atmosphere, T=36."	1.33	Selected biochemical variables in a model of neonatal anoxia in rats. ( Dubovický, M; Mach, M; Navarová, J; Schmidtová, M; Ujházy, E, 2006)
"Hemorrhagic shock was induced in 48 anesthetized rats by withdrawing 28 mL/kg blood."	1.33	Fluid resuscitation with hemoglobin-vesicle solution does not increase hypoxia or inflammatory responses in moderate hemorrhagic shock. ( Goto, Y; Horinouchi, H; Miyashita, M; Sakai, H; Sakamoto, A; Terajima, K; Tsuchida, E; Tsueshita, T, 2006)
"Our data also suggest that chronic hypoxemia depresses mechanosensitive muscle afferents."	1.32	Comparison between the effects of chronic and acute hypoxemia on muscle afferent activities from the tibialis anterior muscle. ( Decherchi, P; Dousset, E; Grelot, L; Jammes, Y, 2003)
"Acute hypoxemia was subsequently induced in all fetuses by reducing maternal fractional inspired oxygen concentration for 1 h."	1.32	Hindlimb glucose and lactate metabolism during umbilical cord compression and acute hypoxemia in the late-gestation ovine fetus. ( Fowden, AL; Gardner, DS; Giussani, DA, 2003)
"Postmortem hypoxemia was induced by cervical dislocation."	1.32	The contribution of glycolytic and oxidative pathways to retinal photoreceptor function. ( Bui, BV; Kalloniatis, M; Vingrys, AJ, 2003)
"Compared with a control group, COPD patients had lower MVCs, an attenuated decrease in MF during exercise, lower resting level of GSH, no posthandgrip TBARS increase and no GSH consumption."	1.32	Influence of chronic hypoxemia on peripheral muscle function and oxidative stress in humans. ( Barbier, D; Faucher, M; Hug, F; Jammes, Y; Steinberg, JG, 2004)
"Adenosine is a product of adenylate phosphate breakdown that can exert protective effects on tissues during energy limitation."	1.32	Cardiorespiratory and tissue adenosine responses to hypoxia and reoxygenation in the short-horned sculpin Myoxocephalus scorpius. ( Driedzic, WR; Maccormack, TJ, 2004)
"After 60 min of anoxia, stage 27HH hearts did not retrieve their baseline activity."	1.31	Developmental changes in cardiac recovery from anoxia-reoxygenation. ( Kucera, P; Raddatz, E; Sedmera, D, 2002)
"During hypoxemia, both the pretreatment with endotoxin and nicotine induced higher levels of extracellular lactate and peak lactate/pyruvate ratio compared with controls (54."	1.31	Detrimental effects of nicotine and endotoxin in the newborn piglet brain during severe hypoxemia. ( Amerio, G; Frøen, JF; Saugstad, OD; Stray-Pedersen, B, 2002)
"In painted turtles anoxia induced a significant increase in myocardial HSP72/73 (from 2."	1.31	Expression of heat shock proteins in turtle and mammal hearts: relationship to anoxia tolerance. ( Chang, J; Knowlton, AA; Wasser, JS, 2000)
"With hypoxemia, time had a significant effect on V(O2) and body temperature in an age-dependent fashion: that is, whereas the 1 week group and the 4-5 week group showed both variables decreasing over time, the 2-3 week group showed no drop in V(O2) and a small increase in body temperature over time."	1.31	Age-dependent metabolic effects of repeated hypoxemia in piglets. ( Barter, J; Côté, A; Meehan, B, 2000)
"Shell and bone ¿Na(+) both fell during anoxia but the fate of this Na(+) is uncertain because plasma ¿Na(+) also fell."	1.31	Bone and shell contribution to lactic acid buffering of submerged turtles Chrysemys picta bellii at 3 degrees C. ( Crocker, CE; Jackson, DC; Ultsch, GR, 2000)
"cylindriformis, survives anoxia for only 2 days at 25 degrees C."	1.31	Anoxia tolerance of con-familial tiger beetle larvae is associated with differences in energy flow and anaerobiosis. ( Hand, SC; Higley, LG; Hoback, WW; Podrabsky, JE; Stanley, DW, 2000)
"Severe hypoxemia induces similar alterations of renal excretion in newborn piglets."	1.31	Effect of severe normocapnic hypoxia on renal function in growth-restricted newborn piglets. ( Bauer, R; Walter, B; Zwiener, U, 2000)
"Although arterial hypoxemia developed during the second run, arterial PO2 values were significantly (P < 0."	1.31	Effect of prior high-intensity exercise on exercise-induced arterial hypoxemia in Thoroughbred horses. ( Goetz, TE; Hassan, AS; Manohar, M, 2001)
"Furthermore, at 15 degrees C anoxia reduced the ATP turnover rate to 50% of the normoxic rate."	1.30	Energy turnover in the normoxic and anoxic turtle heart. ( Arthur, PG; Cousins, KL; Farrell, AP; Franklin, CE; Hochachka, PW; Thorarensen, H, 1997)
"Progressive graded hypoxemia was induced by decreasing fractional inspiratory oxygen concentration (FIO2) from 1."	1.30	Mixed venous oxygen saturation and biochemical parameters of hypoxia during progressive hypoxemia in 10- to 14-day-old piglets. ( Blanco, CE; Maertzdorf, WJ; van der Hoeven, MA, 1997)
"Many enzyme activities in Alzheimer's disease (AD) are changed."	1.30	Affected enzyme activities in Alzheimer's disease are sensitive to antemortem hypoxia. ( Bothmer, J; Jolles, J; Meng, F; Terwel, D; Wolf, E, 1998)
"Lactic acid production was also significantly suppressed in the subzero nonfreezing group compared with that in the control group."	1.30	Subzero nonfreezing storage of isolated rat hepatocytes in University of Wisconsin solution. ( Matsuda, H; Matsuoka, J; Tanaka, N; Yagi, T; Yamamura, H, 1999)
"When hearts could adjust their HR, hypoxemia demanded more energy than ischemia (p < 0."	1.29	Effects of energy demand in ischemic and in hypoxemic isolated rat hearts. ( Allibardi, S; Casalini, S; Corno, A; Samaja, M, 1994)
"Hindlimb O2 transport decreased with hypoxemia, but O2 consumption remained unchanged in both groups."	1.29	Hydroxymalonate inhibits lactate uptake by the rabbit hindlimb. ( Arbelaez, G; Chakravarthy, S; Fernandez, E; Gutierrez, G; Hurtado, FJ; Kiiski, R; Ronco, JJ, 1994)
"To evaluate the effect of hypoxemia on cardiac release of neuropeptide Y-like immunoreactivity (NPY-LI) and norepinephrine (NE), arterial and coronary sinus blood was sampled and coronary sinus blood flow was measured by thermodilution in nine healthy volunteers at rest and during supine cycle ergometer exercise while they breathed air and 12% O2, which reduced arterial O2 saturation to approximately 68%."	1.29	Neuropeptide Y release from human heart is enhanced during prolonged exercise in hypoxia. ( Berglund, B; Grubbström, J; Kaijser, L; Lundberg, JM; Pernow, J, 1994)
"Glycogen depletion by anoxia or glucagon before ischemia impaired recovery."	1.29	Metabolic recovery of isolated working rat heart after brief global ischemia. ( Goodwin, GW; Taegtmeyer, H, 1994)
"Ipsilateral testicular torsion causes a decrease not only in the ipsilateral torted but also in the contralateral nontorted testicular perfusion."	1.29	Ipsilateral and contralateral testicular biochemical acute changes after unilateral testicular torsion and detorsion. ( Akgür, FM; Büyükpamukçu, N; Hiçsönmez, A; Kilinç, K; Tanyel, FC, 1994)
"Maternal hypoxemia resulted in no change in fetal mixed arterio-venous pH (7."	1.29	Cerebral energy metabolism in fetal guinea pigs during moderate maternal hypoxemia at 0.75 of gestation. ( Berger, R; Jensen, A; Krieglstein, J; Steigelmann, JP, 1993)
"Induced hypoxemia resulted in a variable degree of fetal acidemia that was entirely metabolic."	1.29	Cerebral metabolism during sustained hypoxemia in preterm fetal sheep. ( Asano, H; Carmichael, L; Homan, J; Korkola, S; Richardson, B, 1994)
"Induced fetal hypoxemia resulted in a lactic metabolic acidosis that progressively worsened, with death occurring in three of the animals during the early recovery period."	1.29	Recovery of the ovine fetus from sustained hypoxia: effects on endocrine, cardiovascular, and biophysical activity. ( Carmichael, L; Fraher, L; Matsuda, Y; Patrick, J; Richardson, B, 1994)
"During anoxia we measured a four- to sixfold increase of the interstitial lactate concentration."	1.29	Interstitial lactate and glucose concentrations of the isolated perfused rat heart before, during and after anoxia. ( Kammermeier, H; Strupp, M, 1993)
"The present study used a model of cardiac tamponade to investigate the effects of endotoxin on the oxygen extraction capabilities of the body during an acute reduction in blood flow, when blood volume and arterial oxygen content were maintained."	1.29	Oxygen extraction is altered by endotoxin during tamponade-induced stagnant hypoxia in the dog. ( Vincent, JL; Zhang, H, 1993)
"During anoxia all 14C remained in the animal indicating no urine production."	1.29	Lactate distribution and metabolism during and after anoxia in the turtle, Chrysemys picta bellii. ( Jackson, DC; Okamoto, S; Toney, VI, 1996)
"After 45 min of anoxia, total lactate production was less in immature tubules (101 +/- 48 micrograms of lactate/mg of DNA) compared with mature tubules (148 +/- 36 micrograms of lactate/mg of DNA)."	1.29	Glycolysis is not responsible for the tolerance of immature renal tubules to anoxia. ( Gaudio, KM; Siegel, NJ; Thulin, G, 1996)
"Exposure to 30 h anoxia resulted in significant increases in the activities of skeletal muscle and heart catalase (by 53 and 47%), heart and brain glutathione peroxidase (by 75 and 30%), and brain glutathione S-transferase (by 66%)."	1.29	Relationship between anoxia exposure and antioxidant status in the frog Rana pipiens. ( Hermes-Lima, M; Storey, KB, 1996)
"During hypoxemia, pressure dropped initially, as observed during ischemia."	1.29	Dynamics of myocardial adaptation to low-flow ischemia and hypoxemia. ( Allibardi, S; de Jong, JW; Merati, G; Monti, LD; Samaja, M, 1996)
"Induced fetal hypoxemia resulted in a progressive lactic metabolic acidosis; however, all fetuses had recovered within 24 hours."	1.28	Effects of sustained hypoxemia on the sheep fetus at midgestation: endocrine, cardiovascular, and biophysical responses. ( Carmichael, L; Challis, J; Matsuda, Y; Patrick, J; Richardson, B, 1992)
"Lactate formation at the onset of anoxia is proportional to stimulus frequency."	1.28	ATP formation and energy demand in anoxic heart muscle of the rabbit. ( Dietrich, DL; Elzinga, G, 1992)
"To test the hypothesis that long-term hypoxemia affects fetal cardiac function, we measured right (RVO) and left (LVO) ventricular output by electromagnetic flow probes."	1.28	Right and left ventricular function in fetal sheep exposed to long-term high-altitude hypoxemia. ( Gilbert, RD; Kamitomo, M; Longo, LD, 1992)
"In contrast to the hepatoma cells, rat and human hepatocytes exhibited higher rates of anaerobic glycolysis in the presence of fructose and thus were able to maintain their viability under these conditions."	1.28	Differences in glycolytic capacity and hypoxia tolerance between hepatoma cells and hepatocytes. ( Anundi, I; de Groot, H; Hugo-Wissemann, D; Lauchart, W; Viebahn, R, 1991)
"During CO2 acidosis, anoxia had no effect on apparent nonbicarbonate buffer value (d[HCO3-]/dpHi = 71 and 89 mM/pH in normoxia and anoxia, respectively) or on pHi regulation (dpHi/dpHe = 0."	1.28	31P-NMR study of normoxic and anoxic perfused turtle heart during graded CO2 and lactic acidosis. ( Arendt, EA; Inman, KC; Jackson, DC; Lawler, RG; Panol, G; Wasser, JS, 1991)
"Arterial hypoxemia decreased epicardial tissue PO2, measured by means of a multiwire surface electrode, as well as coronary venous PO2 and myocardial lactate extraction."	1.28	Epicardial oxygen tensions during changes in arterial PO2 in pigs. ( Baier, H; Brendel, W; Christ, M; Conzen, PF; Goetz, A; Habazettl, H; Peter, K; Vollmar, B, 1990)
"During anoxia, hyperglycemic cats showed higher brain lactate levels (26 versus 20 mumol/g), but similar ATP and phosphocreatine concentrations, compared with normoglycemic cats."	1.28	Delayed neurologic deterioration following anoxia: brain mitochondrial and metabolic correlates. ( Kleinholz, M; Myers, RE; Wagner, KR, 1989)
"Ischemia and anoxia were induced in the area perfused by the distal left anterior descending artery in 32 mongrel dogs."	1.27	Different effects of acute ischemia and anoxia on the canine myocardium. ( Hattori, S; Mori, H; Nagata, M; Nakamura, Y; Sakurai, K; Takahashi, M, 1984)
"During lung anoxia produced by ventilation with CO, glucose utilization and lactate production were again markedly decreased by addition of lactate (2 mM) to the perfusate."	1.27	Lactate and regulation of lung glycolytic rate. ( Dodia, C; Fisher, AB, 1984)
"The periods of hypoxemia and ischemia lasted 56."	1.27	Bioenergetics of rabbit skeletal muscle during hypoxemia and ischemia. ( Andry, JM; Gutierrez, G; Narayana, P; Pohil, RJ; Strong, R, 1988)
"The effects of prolonged mild hypoxemia on the fetus have received little attention."	1.27	The effect of mild hypoxemia maintained for twenty-four hours on maternal and fetal glucose, lactate, cortisol, and arginine vasopressin in pregnant sheep at 122 to 139 days' gestation. ( Elias, B; Figueroa, J; Markowitz, S; Nathanielsz, P; Towell, ME, 1987)
"When the hypoxemia-induced reduction in O2 consumption was less than 15% of the baseline value (at fractional concentration of inspired oxygen 0."	1.27	Oxygen transport and metabolism in the conscious lamb: the effects of hypoxemia. ( Lister, G; Moreau, G; Moss, M, 1987)
"To examine the effects of hypoxemia on carbohydrate and O2 consumption by the fetal kidney, we inserted catheters into the descending aorta, inferior vena cava, and left renal vein of 14 fetal sheep at 120-130 days gestation."	1.27	Metabolic responses of the kidney in fetal sheep: effect of acute and spontaneous hypoxemia. ( Iwamoto, HS; Rudolph, AM, 1985)
"After 15 min of hypoxemia we repeated the measurements."	1.26	Fetal myocardial oxygen and carbohydrate consumption during acutely induced hypoxemia. ( Fisher, DJ; Heymann, MA; Rudolph, AM, 1982)
"Total lactate rose during anoxia to a mean peak value of 145 mM, but the decrease in HCO-3 and Cl- and increase in K+ balanced less than 40% of the lactate."	1.26	Plasma ion balance of submerged anoxic turtles at 3 degrees C: the role of calcium lactate formation. ( Heisler, N; Jackson, DC, 1982)
"The effect of temperature, either along or in combination with pentobarbital or phenytoin, on survival time in the hypoxic (Flo2 = 0."	1.26	Influence of hypothermia or hyperthermia alone or in combination with pentobarbital or phenytoin on survival time in hypoxic mice. ( Artru, AA; Michenfelder, JD, 1981)
"We conclude that with progressive hypoxemia, CMRO2 remains stable until oxygen demand exceeds oxygen delivery, resulting thereafter in a progressive reduction in CMRO2."	1.26	Canine cerebral metabolism and blood flow during hypoxemia and normoxic recovery from hypoxemia. ( Artru, AA; Michenfelder, JD, 1981)

Timeframe	Studies, this research(%)	All Research%
pre-1990	142 (15.57)	18.7374
1990's	206 (22.59)	18.2507
2000's	254 (27.85)	29.6817
2010's	218 (23.90)	24.3611
2020's	92 (10.09)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Study on the Diagnostic Value of Multi-omics Combined Detection for Precancerous Lesions of Colorectal Cancer[NCT05530746]		500 participants (Anticipated)	Observational	2022-05-01	Recruiting
An Open-label, Multi-center, Phase 1b Study to Investigate the Safety and Tolerability of SLC-0111 (WBI-5111) in Combination With Gemcitabine in Metastatic Pancreatic Ductal Adenocarcinoma Subjects Positive for Carbonic Anhydrase IX[NCT03450018]	Phase 1/Phase 2	30 participants (Anticipated)	Interventional	2019-01-10	Recruiting
An Observational Cohort Study to Validate SEARCH, a Novel Hierarchical Algorithm to Define Long-term Outcomes After Pulmonary Embolism[NCT05568927]		150 participants (Anticipated)	Observational	2022-11-01	Enrolling by invitation
Mean Arterial Pressure (MAP) Trial: Study Protocol for a Multicenter, Randomized, Controlled Trial to Compare Three Different Strategies of Mean Arterial Pressure Management During Cardiopulmonary By-pass[NCT05740397]		900 participants (Anticipated)	Interventional	2021-05-03	Recruiting
Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)[NCT05120284]	Phase 2	40 participants (Anticipated)	Interventional	2022-07-01	Recruiting
Renal Effects of Erythropoietin in Humans[NCT01584921]	Phase 1	16 participants (Actual)	Interventional	2012-03-31	Completed
Effects of Endogenous Iron Status and Intravenous Iron on Human Skeletal Muscle Metabolism at Rest and During Exercise[NCT02308449]		29 participants (Actual)	Interventional	2014-10-31	Completed
Using the ΔvapCO2 / Cav02 Ratio as a Prognostic Marker and Predictor of Complications After Cardiac Surgery[NCT02876406]		150 participants (Anticipated)	Observational [Patient Registry]	2016-10-31	Recruiting
Peripheral Perfusion Versus Lactate Targeted Fluid Resuscitation in Septic Shock: ANDROMEDA-SHOCK PHYSIOLOGY STUDY[NCT03762005]		46 participants (Anticipated)	Interventional	2018-06-01	Recruiting
Brain During Effort : Effects of Hypoxia With Respiratory Patients[NCT02854280]		33 participants (Actual)	Interventional	2013-06-30	Completed
Agreement Between Arterial, Central Venous, and Peripheral Venous Lactate in the Intensive Care Unit[NCT01624519]		50 participants (Anticipated)	Interventional	2012-08-31	Not yet recruiting
Remote Ischemic Conditioning as a Treatment for Traumatic Brain Injury: a Prospective Randomized Controlled Trial.[NCT03176823]		40 participants (Anticipated)	Interventional	2019-05-03	Recruiting
Markers of Tissue Perfusion as Predictors of Complicated Evolution in Patients With Left Ventricular Dysfunction Submitted to Coronary Artery Bypass Surgery[NCT01178866]		87 participants (Actual)	Observational	2006-01-31	Completed
Effect of Exercise-induced Hypoxemia on Cytokine and Stress Hormone Responses Among Endurance-trained Athletes[NCT04305873]		50 participants (Anticipated)	Observational	2020-03-01	Enrolling by invitation
Resuscitation Failure, Protein Carbonyl and Receptor Interacting Protein Kinase 3 as Mortality Predictor in Septic Patient[NCT04169412]		72 participants (Actual)	Observational [Patient Registry]	2019-02-22	Completed
"Influence of High Vitamin C Dose on Lactate During Extracorporeal Circulation for Heart Surgery and During the 24 Hours Thereafter. (Double Blind Prospective Randomised Study)"[NCT04046861]		200 participants (Anticipated)	Interventional	2023-02-01	Not yet recruiting
Effectiveness of Chest Compressions Under Mild Hypoxia: Should Rescuers Breathe Supplemental Oxygen on Commercial Flights?[NCT04072484]		19 participants (Actual)	Interventional	2019-08-16	Terminated (stopped due to Research at the University of Chicago was halted in March 2020.)
Cardiovascular and Metabolic Physiological Adaptations to Intermittent Hypoxia. Physiological Aspects and Expression of Receptors and Cellular Mediators[NCT02058823]	Phase 4	12 participants (Actual)	Interventional	2013-08-07	Terminated (stopped due to budget constraints)
The Insulin Sensitivity Using Aerobic Interval Conditioning[NCT01286922]		42 participants (Actual)	Interventional	2009-07-31	Completed
Near-infrared Spectroscopic Measurement of Tissue Oxygen Saturation and the Vascular Occlusion Test in Complex Regional Pain Syndrome[NCT01586377]		20 participants (Actual)	Observational	2011-08-31	Completed
Long-term Oxygen Therapy in Patients With Chronic Obstructive Pulmonary Disease (COPD) Who Live at High Altitude (2640 Meters Above Sea Level): Evaluation of a Proposal for Adjusting Criteria[NCT03020212]		220 participants (Anticipated)	Interventional	2016-02-29	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Lactate Supply from Astrocytes to Neurons and its Role in Ischemic Stroke-induced Neurodegeneration. Neuroscience, 2022, 01-15, Volume: 481 Topics: Animals; Astrocytes; Hypoxia; Ischemic Stroke; Lactic Acid; Neurons	2022
'Warburg effect' controls tumor growth, bacterial, viral infections and immunity - Genetic deconstruction and therapeutic perspectives. Seminars in cancer biology, 2022, Volume: 86, Issue:Pt 2 Topics: Animals; Bacteria; Cell Line, Tumor; Humans; Hypoxia; Lactic Acid; Monocarboxylic Acid Transporters;	2022
Exogenous lactate administration: A potential novel therapeutic approach for neonatal hypoxia-ischemia. Experimental neurology, 2023, Volume: 367 Topics: Humans; Hypothermia; Hypothermia, Induced; Hypoxia; Hypoxia-Ischemia, Brain; Infant, Newborn; Ischem	2023
Lactate acidosis and simultaneous recruitment of TGF-β leads to alter plasticity of hypoxic cancer cells in tumor microenvironment. Pharmacology & therapeutics, 2023, Volume: 250 Topics: Acidosis; Humans; Hypoxia; Lactic Acid; Neoplasms; Transforming Growth Factor beta; Tumor Microenvir	2023
L-lactic acidosis: pathophysiology, classification, and causes; emphasis on biochemical and metabolic basis. Kidney international, 2020, Volume: 97, Issue:1 Topics: Acidosis, Lactic; Anions; Bicarbonates; Citric Acid Cycle; Critical Illness; Electron Transport Chai	2020
Hyperlactatemia: An Update on Postoperative Lactate. World journal for pediatric & congenital heart surgery, 2020, Volume: 11, Issue:3 Topics: Acidosis, Lactic; Biomarkers; Cardiac Surgical Procedures; Female; Humans; Hyperlactatemia; Hypoxia;	2020
Astrocytic nutritional dysfunction associated with hypoxia-induced neuronal vulnerability in stroke-prone spontaneously hypertensive rats. Neurochemistry international, 2020, Volume: 138 Topics: Animals; Astrocytes; Cell Death; Cells, Cultured; Humans; Hypertension; Hypoxia; Lactic Acid; Neuron	2020
Practical Management of ECPELLA. International heart journal, 2020, Nov-28, Volume: 61, Issue:6 Topics: Acidosis; Assisted Circulation; Combined Modality Therapy; Extracorporeal Membrane Oxygenation; Femo	2020
Quantitative Assessment of Blood Lactate in Shock: Measure of Hypoxia or Beneficial Energy Source. BioMed research international, 2020, Volume: 2020 Topics: Animals; Critical Illness; Disease Models, Animal; Dogs; Humans; Hypoxia; Lactic Acid; Liver; Models	2020
Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance. Cells, 2020, 12-04, Volume: 9, Issue:12 Topics: Amino Acids; Animals; Citric Acid Cycle; Dimerization; Disease Progression; Drug Resistance, Neoplas	2020
The role of lactate in sepsis and COVID-19: Perspective from contracting skeletal muscle metabolism. Experimental physiology, 2022, Volume: 107, Issue:7 Topics: Adrenergic Agents; COVID-19; Humans; Hypoxia; Lactate Dehydrogenases; Lactic Acid; Muscle, Skeletal;	2022
Exercise during short-term exposure to hypoxia or hyperoxia - novel treatment strategies for type 2 diabetic patients?! Scandinavian journal of medicine & science in sports, 2018, Volume: 28, Issue:2 Topics: Diabetes Mellitus, Type 2; Exercise Therapy; Glucose; Humans; Hyperoxia; Hypoxia; Insulin Resistance	2018
Lactate metabolism: historical context, prior misinterpretations, and current understanding. European journal of applied physiology, 2018, Volume: 118, Issue:4 Topics: Astrocytes; Energy Metabolism; Exercise; Humans; Hypoxia; Lactic Acid; Neurons	2018
Lactate as a signaling molecule: Journey from dead end product of glycolysis to tumor survival. Frontiers in bioscience (Landmark edition), 2019, 01-01, Volume: 24, Issue:2 Topics: Cell Hypoxia; Cell Line, Tumor; Cell Survival; Glycolysis; Humans; Hydrogen-Ion Concentration; Hypox	2019
The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression. International journal of radiation biology, 2019, Volume: 95, Issue:7 Topics: Adenosine Triphosphate; Animals; Biomass; Cell Line, Tumor; Cell Proliferation; Cellular Reprogrammi	2019
Hypoxia, lactate accumulation, and acidosis: siblings or accomplices driving tumor progression and resistance to therapy? Advances in experimental medicine and biology, 2013, Volume: 789 Topics: Acidosis; Disease Progression; Drug Resistance, Neoplasm; Humans; Hypoxia; Lactic Acid; Neoplasms	2013
Lactate or ScvO2 as an endpoint in resuscitation of shock states? Minerva anestesiologica, 2013, Volume: 79, Issue:9 Topics: Endpoint Determination; Humans; Hypoxia; Lactic Acid; Oxygen; Prognosis; Resuscitation; Shock; Shock	2013
Lactate and the injured brain: friend or foe? Current opinion in critical care, 2014, Volume: 20, Issue:2 Topics: Brain Injuries; Cerebral Cortex; Cerebrovascular Circulation; Energy Metabolism; Female; Glycolysis;	2014
Analysis of hypoxia-induced metabolic reprogramming. Methods in enzymology, 2014, Volume: 542 Topics: Autophagy; Carbon Isotopes; Cell Culture Techniques; Culture Media; Glucose; Glycolysis; Humans; Hyd	2014
Metabolic aspects of high-altitude adaptation in Tibetans. Experimental physiology, 2015, Volume: 100, Issue:11 Topics: Adaptation, Physiological; Altitude; Basic Helix-Loop-Helix Transcription Factors; Energy Metabolism	2015
Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters. Journal of molecular medicine (Berlin, Germany), 2016, Volume: 94, Issue:2 Topics: Animals; Antineoplastic Agents; Basigin; Biomarkers; Energy Metabolism; Humans; Hypoxia; Lactic Acid	2016
Performance Enhancement: What Are the Physiological Limits? Physiology (Bethesda, Md.), 2015, Volume: 30, Issue:4 Topics: Acclimatization; Adaptation, Physiological; Altitude; Anaerobic Threshold; Exercise; Humans; Hypoxia	2015
The Kenyan runners. Scandinavian journal of medicine & science in sports, 2015, Volume: 25 Suppl 4 Topics: Ammonia; Arteries; Athletic Performance; Humans; Hypoxia; Kenya; Lactic Acid; Lung; Muscle, Skeletal	2015
Cerebral Lactate Metabolism After Traumatic Brain Injury. Current neurology and neuroscience reports, 2016, Volume: 16, Issue:4 Topics: Animals; Brain Injuries; Cerebrovascular Circulation; Glucose; Humans; Hypoxia; Lactic Acid; Neuropr	2016
Hyperlactatemia and Cardiac Surgery. The journal of extra-corporeal technology, 2017, Volume: 49, Issue:1 Topics: Acidosis, Lactic; Biomarkers; Cardiac Surgical Procedures; Humans; Hyperlactatemia; Hypoxia; Lactic	2017
The anti-oxidant capacity of tumour glycolysis. International journal of radiation biology, 2009, Volume: 85, Issue:11 Topics: Animals; Antioxidants; DNA Damage; Glycolysis; Humans; Hypoxia; Lactic Acid; Luminescent Measurement	2009
Hypoxia-inducible factors and their roles in energy metabolism. International journal of hematology, 2012, Volume: 95, Issue:5 Topics: Animals; Carbohydrate Metabolism; Energy Metabolism; Humans; Hypoxia; Hypoxia-Inducible Factor 1; La	2012
Blood flow and associated pathophysiology of uterine cervix cancers: characterisation and relevance for localised hyperthermia. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2012, Volume: 28, Issue:6 Topics: Animals; Cervix Uteri; Female; Glucose; Humans; Hyperthermia, Induced; Hypoxia; Lactic Acid; Uterine	2012
Endothelial cell metabolism and tumour angiogenesis: glucose and glutamine as essential fuels and lactate as the driving force. Journal of internal medicine, 2013, Volume: 273, Issue:2 Topics: Angiogenesis Inhibitors; Endothelial Cells; Endothelium, Vascular; Glucose; Glutamine; Glycolysis; H	2013
Metabolomics--a novel window into inflammatory disease. Swiss medical weekly, 2013, Volume: 143 Topics: Animals; Biomarkers; Energy Metabolism; Humans; Hypoxia; Inflammation; Lactic Acid; Metabolomics; Me	2013
Cellular pathophysiology. Part 2: Responses following hypoxia. Professional nurse (London, England), 2003, Volume: 18, Issue:11 Topics: Blood Volume; Calcium; Cell Membrane; Cell Physiological Phenomena; Energy Metabolism; Free Radicals	2003
Performing at extreme altitude: muscle cellular and subcellular adaptations. European journal of applied physiology, 2003, Volume: 90, Issue:3-4 Topics: Acclimatization; Adult; Altitude; Atmospheric Pressure; Body Weight; Citrate (si)-Synthase; Electron	2003
Acid-base balance at exercise in normoxia and in chronic hypoxia. Revisiting the "lactate paradox". European journal of applied physiology, 2003, Volume: 90, Issue:5-6 Topics: Acid-Base Equilibrium; Adenosine Triphosphate; Energy Metabolism; Exercise; Glycolysis; Homeostasis;	2003
Limiting factors to oxygen transport on Mount Everest 30 years after: a critique of Paolo Cerretelli's contribution to the study of altitude physiology. European journal of applied physiology, 2003, Volume: 90, Issue:3-4 Topics: Acclimatization; Altitude; Arteries; Atmospheric Pressure; Capillaries; Cardiac Output; Cardiovascul	2003
Arterial desaturation during exercise in man: implication for O2 uptake and work capacity. Scandinavian journal of medicine & science in sports, 2003, Volume: 13, Issue:6 Topics: Adolescent; Adult; Aged; Animals; Blood Gas Analysis; Cardiovascular Physiological Phenomena; Child;	2003
Acid-base balance during hypoxic hypometabolism: selected vertebrate strategies. Respiratory physiology & neurobiology, 2004, Aug-12, Volume: 141, Issue:3 Topics: Acclimatization; Acid-Base Equilibrium; Animals; Carbon Dioxide; Environment; Fishes; Hydrogen-Ion C	2004
Surviving extreme lactic acidosis: the role of calcium lactate formation in the anoxic turtle. Respiratory physiology & neurobiology, 2004, Dec-15, Volume: 144, Issue:2-3 Topics: Acidosis, Lactic; Adaptation, Physiological; Animals; Bone and Bones; Calcium; Calcium Compounds; Hu	2004
Bench-to-bedside review: oxygen debt and its metabolic correlates as quantifiers of the severity of hemorrhagic and post-traumatic shock. Critical care (London, England), 2005, Oct-05, Volume: 9, Issue:5 Topics: Acid-Base Equilibrium; Acidosis; Animals; Disease Models, Animal; Dogs; Humans; Hypovolemia; Hypoxia	2005
Lactate as a marker of energy failure in critically ill patients: hypothesis. Critical care (London, England), 2005, Volume: 9, Issue:6 Topics: Acid-Base Equilibrium; Biomarkers; Critical Care; Critical Illness; Disease Progression; Energy Meta	2005
Lactate and shock state: the metabolic view. Current opinion in critical care, 2006, Volume: 12, Issue:4 Topics: Humans; Hypoxia; Lactic Acid; Shock	2006
Lactate and shock state: the metabolic view. Current opinion in critical care, 2006, Volume: 12, Issue:4 Topics: Humans; Hypoxia; Lactic Acid; Shock	2006
Lactate and shock state: the metabolic view. Current opinion in critical care, 2006, Volume: 12, Issue:4 Topics: Humans; Hypoxia; Lactic Acid; Shock	2006
Lactate and shock state: the metabolic view. Current opinion in critical care, 2006, Volume: 12, Issue:4 Topics: Humans; Hypoxia; Lactic Acid; Shock	2006
Fundamentals of oxygen delivery. Contributions to nephrology, 2007, Volume: 156 Topics: Biological Transport; Energy Metabolism; Humans; Hypoxia; Lactic Acid; Lung; Mitochondria; Oxygen	2007
Lactate metabolism in anoxic turtles: an integrative review. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2008, Volume: 178, Issue:2 Topics: Adaptation, Physiological; Animals; Hypoxia; Lactic Acid; Turtles	2008
Tumor-induced modulation of dendritic cell function. Cytokine & growth factor reviews, 2008, Volume: 19, Issue:1 Topics: Animals; Cell Differentiation; Cyclooxygenase 2; Dendritic Cells; Dinoprostone; Humans; Hypoxia; Lac	2008
A reexamination of the role of oxygen in retrolental fibroplasia. Pediatrics, 1984, Volume: 73, Issue:1 Topics: Anencephaly; Apnea; Carbon Dioxide; Cerebral Hemorrhage; Ductus Arteriosus, Patent; Exchange Transfu	1984
Potassium loss during myocardial ischaemia and hypoxia: does lactate efflux play a role? Cardiovascular research, 1994, Volume: 28, Issue:8 Topics: Biological Transport; Cell Membrane; Humans; Hypoxia; Lactates; Lactic Acid; Myocardial Ischemia; My	1994
[Is infection and septic shock caused by a global oxygen deficiency? An overview in 2 parts. 1: Infection and correlation between DO2 and VO2]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 1996, Volume: 31, Issue:3 Topics: Acid-Base Equilibrium; Cardiac Output; Humans; Hypoxia; Lactates; Lactic Acid; Oxygen; Oxygen Consum	1996
Lactate during exercise at high altitude. European journal of applied physiology and occupational physiology, 1996, Volume: 74, Issue:3 Topics: Acclimatization; Altitude; Biological Transport, Active; Glycogen; Glycolysis; Humans; Hypoxia; Lact	1996
Is the maximal accumulated oxygen deficit an adequate measure of the anaerobic capacity? Canadian journal of applied physiology = Revue canadienne de physiologie appliquee, 1996, Volume: 21, Issue:5 Topics: Anaerobic Threshold; Anaerobiosis; Exercise; Humans; Hypoxia; Lactic Acid; Muscle, Skeletal; Oxygen	1996
Brain anaerobic lactate production: a suicide note or a survival kit? Developmental neuroscience, 1998, Volume: 20, Issue:4-5 Topics: Anaerobiosis; Animals; Brain; Brain Ischemia; Energy Metabolism; Hypoxia; Lactic Acid	1998
[Clinical evaluation and methodological aspects of serum lactate]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 1999, Volume: 34, Issue:4 Topics: Biomarkers; Humans; Hypoxia; Lactic Acid	1999
Lactate is an unreliable indicator of tissue hypoxia in injury or sepsis. Lancet (London, England), 1999, Aug-07, Volume: 354, Issue:9177 Topics: Cell Hypoxia; Humans; Hypoxia; Lactic Acid; Resuscitation; Sensitivity and Specificity; Systemic Inf	1999
Lung injury and lactate production: a hypoxic stimulus? Critical care medicine, 1999, Volume: 27, Issue:11 Topics: Biomarkers; Humans; Hypoxia; Lactic Acid; Lung; Respiratory Distress Syndrome	1999
Anaerobic performance at altitude. International journal of sports medicine, 1992, Volume: 13 Suppl 1 Topics: Acclimatization; Altitude; Energy Metabolism; Exercise; Humans; Hypoxia; Lactates; Lactic Acid; Musc	1992
Contact lens-induced corneal endothelial polymegathism: functional significance and possible mechanisms. American journal of optometry and physiological optics, 1986, Volume: 63, Issue:7 Topics: Actin Cytoskeleton; Biomechanical Phenomena; Calcium; Carbon Dioxide; Contact Lenses; Cornea; Cornea	1986
Inflammation, glycolytic metabolism, and glycosaminoglycans. Experimental pathology, 1986, Volume: 30, Issue:1 Topics: Aerobiosis; Animals; Cell Division; Cells, Cultured; Glycolysis; Glycosaminoglycans; Hypoxia; Inflam	1986

Article	Year
Systemic Lactate Elevation Induced by Tobacco Smoking during Rest and Exercise Is Not Associated with Nicotine. International journal of environmental research and public health, 2022, 03-02, Volume: 19, Issue:5 Topics: Adult; Carbon; Cross-Over Studies; Electronic Nicotine Delivery Systems; Humans; Hypoxia; Lactic Aci	2022
Repeated Short-Term Bouts of Hyperoxia Improve Aerobic Performance in Acute Hypoxia. Journal of strength and conditioning research, 2023, Oct-01, Volume: 37, Issue:10 Topics: Bicycling; Female; Humans; Hyperoxia; Hypoxia; Lactic Acid; Male; Oxygen	2023
Sessional work-rate does not affect the magnitude to which simulated hypoxia can augment acute physiological responses during resistance exercise. European journal of applied physiology, 2020, Volume: 120, Issue:10 Topics: Exercise Tolerance; Heart Rate; Humans; Hypoxia; Lactic Acid; Male; Muscle, Skeletal; Oxygen Consump	2020
Longitudinal Monitoring of Lactate in Hospitalized and Ambulatory COVID-19 Patients. The American journal of tropical medicine and hygiene, 2021, Jan-11, Volume: 104, Issue:3 Topics: Adolescent; Adult; Ambulatory Care Facilities; Biomarkers; Comorbidity; COVID-19; Female; Germany; H	2021
Four weeks of high-intensity training in moderate, but not mild hypoxia improves performance and running economy more than normoxic training in horses. Physiological reports, 2021, Volume: 9, Issue:4 Topics: Animals; Biomarkers; Cardiorespiratory Fitness; Cross-Over Studies; Exercise Test; Exercise Toleranc	2021
Blueberry supplementation reduces the blood lactate response to running in normobaric hypoxia but has no effect on performance in recreational runners. Journal of the International Society of Sports Nutrition, 2021, Mar-30, Volume: 18, Issue:1 Topics: Adult; Anthocyanins; Athletic Performance; Biomarkers; Blueberry Plants; Cross-Over Studies; Dietary	2021
Normobaric hypoxia increases the growth hormone response to maximal resistance exercise in trained men. European journal of sport science, 2017, Volume: 17, Issue:7 Topics: Adult; Cross-Over Studies; Electromyography; Exercise; Heart Rate; Human Growth Hormone; Humans; Hyp	2017
Changes in acid-base and ion balance during exercise in normoxia and normobaric hypoxia. European journal of applied physiology, 2017, Volume: 117, Issue:11 Topics: Acid-Base Equilibrium; Adult; Exercise; Humans; Hypoxia; Lactic Acid; Male; Oxygen	2017
Acute effects of repeated cycling sprints in hypoxia induced by voluntary hypoventilation. European journal of applied physiology, 2017, Volume: 117, Issue:12 Topics: Adult; Bicycling; Hemoglobins; Humans; Hypoventilation; Hypoxia; Lactic Acid; Male; Myoglobin; Oxyge	2017
Effect of high-intensity resistance circuit-based training in hypoxia on aerobic performance and repeat sprint ability. Scandinavian journal of medicine & science in sports, 2018, Volume: 28, Issue:10 Topics: Adult; Athletic Performance; Basal Metabolism; Energy Metabolism; Hemoglobins; High-Intensity Interv	2018
Acute Effects of Interset Rest Duration on Physiological and Perceptual Responses to Resistance Exercise in Hypoxia. Journal of strength and conditioning research, 2020, Volume: 34, Issue:8 Topics: Adult; Cross-Over Studies; Electromyography; Heart Rate; Humans; Hypoxia; Lactic Acid; Male; Myalgia	2020
Bench press performance during an intermittent hypoxic resistance training to muscle failure. The Journal of sports medicine and physical fitness, 2019, Volume: 59, Issue:7 Topics: Adult; Cross-Over Studies; Humans; Hypoxia; Lactic Acid; Male; Muscle Fatigue; Myalgia; Resistance T	2019
Partial Range of Motion Exercise Is Effective for Facilitating Muscle Hypertrophy and Function Through Sustained Intramuscular Hypoxia in Young Trained Men. Journal of strength and conditioning research, 2019, Volume: 33, Issue:5 Topics: Arm; Electromyography; Humans; Hypertrophy; Hypoxia; Lactic Acid; Male; Muscle Strength; Muscle Stre	2019
Effects of oxytocin and carbetocin on farrowing performance. Animal reproduction science, 2019, Volume: 205 Topics: Animals; Animals, Newborn; Female; Fetal Blood; Hypoxia; Lactic Acid; Oxytocics; Oxytocin; Parturiti	2019
Ischemic Preconditioning Maintains Performance on Two 5-km Time Trials in Hypoxia. Medicine and science in sports and exercise, 2019, Volume: 51, Issue:11 Topics: Adult; Bicycling; Cross-Over Studies; Heart Rate; Humans; Hypoxia; Ischemic Preconditioning; Lactic	2019
[Individual systemic reactions of human organism under acute hypoxia]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2012, Volume: 98, Issue:11 Topics: Adult; Blood Flow Velocity; Blood Glucose; Brain; Brain Waves; Cerebrovascular Circulation; Energy M	2012
Effect of different simulated altitudes on repeat-sprint performance in team-sport athletes. International journal of sports physiology and performance, 2014, Volume: 9, Issue:5 Topics: Acid-Base Equilibrium; Altitude; Athletic Performance; Biomarkers; Competitive Behavior; Group Proce	2014
Effects of resistance training under hypoxic conditions on muscle hypertrophy and strength. Clinical physiology and functional imaging, 2015, Volume: 35, Issue:3 Topics: Biomarkers; Healthy Volunteers; Human Growth Hormone; Humans; Hypertrophy; Hypoxia; Lactic Acid; Mal	2015
Effects of acute exposure to mild simulated hypoxia on hormonal responses to low-intensity resistance exercise in untrained men. Research in sports medicine (Print), 2014, Volume: 22, Issue:3 Topics: Adult; Biomarkers; Cross-Over Studies; Exercise; Healthy Volunteers; Human Growth Hormone; Humans; H	2014
Impact of exercise and moderate hypoxia on glycemic regulation and substrate oxidation pattern. PloS one, 2014, Volume: 9, Issue:10 Topics: Adult; Blood Glucose; Exercise; Fatty Acids, Nonesterified; Glycerol; Heart Rate; Humans; Hypoxia; I	2014
Effect of Intermittent Hypoxic Training Followed by Intermittent Hypoxic Exposure on Aerobic Capacity of Long Distance Runners. Journal of strength and conditioning research, 2016, Volume: 30, Issue:6 Topics: Adaptation, Physiological; Adult; Exercise Test; Exercise Tolerance; Female; Heart Rate; Humans; Hyp	2016
Effect of repeat-sprint training in hypoxia on post-exercise interleukin-6 and F2-isoprostanes. European journal of sport science, 2016, Volume: 16, Issue:8 Topics: Adult; Altitude; F2-Isoprostanes; Heart Rate; Humans; Hypoxia; Inflammation; Interleukin-6; Lactic A	2016
Seven Passive 1-h Hypoxia Exposures Do Not Prevent AMS in Susceptible Individuals. Medicine and science in sports and exercise, 2016, Volume: 48, Issue:12 Topics: Acclimatization; Adult; Altitude Sickness; Blood Gas Analysis; Double-Blind Method; Female; Heart Ra	2016
Short-Term Hypoxic Exposure and Training Improve Maximal Anaerobic Running Test Performance. Journal of strength and conditioning research, 2018, Volume: 32, Issue:1 Topics: Female; Humans; Hypoxia; Lactic Acid; Oxygen Consumption; Physical Endurance; Running; Young Adult	2018
Biochemical responses and physical performance during high-intensity resistance circuit training in hypoxia and normoxia. European journal of applied physiology, 2017, Volume: 117, Issue:4 Topics: Adult; Anaerobic Threshold; Bicarbonates; Exercise Tolerance; High-Intensity Interval Training; Huma	2017
Physiological Factors Associated With Declining Repeated Sprint Performance in Hypoxia. Journal of strength and conditioning research, 2019, Volume: 33, Issue:1 Topics: Acceleration; Adult; Athletes; Athletic Performance; Cross-Over Studies; Exercise Test; Heart Rate;	2019
High-intensity kayak performance after adaptation to intermittent hypoxia. International journal of sports physiology and performance, 2006, Volume: 1, Issue:3 Topics: Adaptation, Physiological; Adolescent; Adult; Athletic Performance; Biomarkers; Cross-Over Studies;	2006
Altitude hypoxia increases glucose uptake in human heart. High altitude medicine & biology, 2009,Spring, Volume: 10, Issue:1 Topics: Adult; Altitude; Fluorodeoxyglucose F18; Glucose; Heart; Humans; Hypoxia; Lactic Acid; Male; Myocard	2009
Cycling performance following adaptation to two protocols of acutely intermittent hypoxia. International journal of sports physiology and performance, 2009, Volume: 4, Issue:1 Topics: Adaptation, Physiological; Adult; Bicycling; Confidence Intervals; Exercise Test; Heart Rate; Humans	2009
The role of ribose on oxidative stress during hypoxic exercise: a pilot study. Journal of medicinal food, 2009, Volume: 12, Issue:3 Topics: Antioxidants; Bicycling; Cross-Over Studies; Dietary Carbohydrates; Dietary Supplements; Double-Blin	2009
Acute altitude-induced hypoxia suppresses plasma glucose and leptin in healthy humans. Metabolism: clinical and experimental, 2010, Volume: 59, Issue:2 Topics: Adult; Altitude; Blood Glucose; C-Peptide; Epinephrine; Female; Glucose; Humans; Hypoxia; Insulin; I	2010
Substrate utilization during exercise and recovery at moderate altitude. Metabolism: clinical and experimental, 2010, Volume: 59, Issue:7 Topics: Adult; Altitude; Anaerobic Threshold; Blood Glucose; Carbon Dioxide; Cardiovascular Physiological Ph	2010
Training in normobaric hypoxia and its effects on acute mountain sickness after rapid ascent to 4559 m. High altitude medicine & biology, 2010,Spring, Volume: 11, Issue:1 Topics: Acclimatization; Adult; Altitude Sickness; Blood Gas Analysis; Double-Blind Method; Female; Heart Ra	2010
Exercise with hypoventilation induces lower muscle oxygenation and higher blood lactate concentration: role of hypoxia and hypercapnia. European journal of applied physiology, 2010, Volume: 110, Issue:2 Topics: Adult; Bicycling; Carbon Dioxide; Ear; Exercise; Hemoglobins; Humans; Hypercapnia; Hypoventilation;	2010
Effects of erythropoietin administration on cerebral metabolism and exercise capacity in men. Journal of applied physiology (Bethesda, Md. : 1985), 2010, Volume: 109, Issue:2 Topics: Adolescent; Adult; Biomarkers; Blood Flow Velocity; Blood Glucose; Blood-Brain Barrier; Brain; Cereb	2010
Blood lactate and pyruvate levels in the perioperative period of liver resection with Pringle maneuver. Clinical hemorheology and microcirculation, 2010, Volume: 44, Issue:4 Topics: Bile Ducts; Blood Loss, Surgical; Constriction; Female; Hepatectomy; Hepatic Artery; Humans; Hypoxia	2010
Effect of intermittent hypoxia on muscle and cerebral oxygenation during a 20-km time trial in elite athletes: a preliminary report. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2010, Volume: 35, Issue:4 Topics: Adolescent; Adult; Biomarkers; Blood Glucose; Carbon Dioxide; Cerebrovascular Circulation; Heart Rat	2010
Intermittent exercise with and without hypoxia improves insulin sensitivity in individuals with type 2 diabetes. The Journal of clinical endocrinology and metabolism, 2012, Volume: 97, Issue:4 Topics: Algorithms; Blood Glucose; Cross-Over Studies; Deuterium; Diabetes Mellitus, Type 2; Exercise; Gluco	2012
The effects of hypoxia acclimation, exercise training and fasting on swimming performance in juvenile qingbo (Spinibarbus sinensis). Fish physiology and biochemistry, 2012, Volume: 38, Issue:5 Topics: Acclimatization; Animals; Blood Glucose; Cyprinidae; Food Deprivation; Glycogen; Hypoxia; Lactic Aci	2012
Four weeks of normobaric "live high-train low" do not alter muscular or systemic capacity for maintaining pH and K⁺ homeostasis during intense exercise. Journal of applied physiology (Bethesda, Md. : 1985), 2012, Volume: 112, Issue:12 Topics: Adult; Altitude; Bicarbonates; Carbon Dioxide; Double-Blind Method; Exercise; Exercise Test; Female;	2012
Short-term supplementation with alpha-ketoglutaric acid and 5-hydroxymethylfurfural does not prevent the hypoxia induced decrease of exercise performance despite attenuation of oxidative stress. International journal of sports medicine, 2013, Volume: 34, Issue:1 Topics: Adult; Aldehydes; Altitude; Antioxidants; Athletic Performance; Double-Blind Method; Exercise; Exerc	2013
Thigh oxygen uptake at the onset of intense exercise is not affected by a reduction in oxygen delivery caused by hypoxia. American journal of physiology. Regulatory, integrative and comparative physiology, 2012, Oct-15, Volume: 303, Issue:8 Topics: Adult; Anaerobic Threshold; Analysis of Variance; Biopsy; Denmark; Double-Blind Method; Exercise; Ex	2012
Acute hypoxemia does not increase the oxidative stress in resting and contracting muscle in humans. Free radical research, 2002, Volume: 36, Issue:6 Topics: Adult; Ascorbic Acid; Exercise Test; Humans; Hypoxia; Lactic Acid; Male; Muscle Contraction; Oxidati	2002
Why is VO2 max after altitude acclimatization still reduced despite normalization of arterial O2 content? American journal of physiology. Regulatory, integrative and comparative physiology, 2003, Volume: 284, Issue:2 Topics: Acclimatization; Acid-Base Equilibrium; Adult; Altitude; Blood Circulation; Blood Gas Analysis; Card	2003
Effect of low oxygen inhalation on changes in blood pH, lactate, and ammonia due to exercise. European journal of applied physiology, 2004, Volume: 91, Issue:2-3 Topics: Adult; Ammonia; Anaerobic Threshold; Blood Chemical Analysis; Carbon Dioxide; Exercise; Humans; Hydr	2004
Acute exposure to moderate high altitude decreases growth hormone response to physical exercise in untrained subjects. The Journal of sports medicine and physical fitness, 2003, Volume: 43, Issue:4 Topics: Adult; Altitude; Exercise Test; Growth Hormone; Humans; Hypoxia; Insulin-Like Growth Factor I; Lacti	2003
Does exercise-induced hypoxemia modify lactate influx into erythrocytes and hemorheological parameters in athletes? Journal of applied physiology (Bethesda, Md. : 1985), 2004, Volume: 97, Issue:3 Topics: Adaptation, Physiological; Adult; Blood Viscosity; Erythrocytes; Exercise Test; Hematocrit; Hemorheo	2004
Effects of acute hypoxia on the estimation of lactate threshold from ventilatory gas exchange indices during an incremental exercise test. Physiological research, 2004, Volume: 53, Issue:6 Topics: Acute Disease; Adult; Anaerobic Threshold; Exercise Test; Humans; Hypoxia; Lactic Acid; Male; Oxygen	2004
Individual variation in the reduction of heart rate and performance at lactate thresholds in acute normobaric hypoxia. International journal of sports medicine, 2005, Volume: 26, Issue:7 Topics: Adult; Altitude; Anaerobic Threshold; Exercise; Exercise Test; Heart Rate; Humans; Hypoxia; Lactic A	2005
Effect of exercise intensity and hypoxia on skeletal muscle AMPK signaling and substrate metabolism in humans. American journal of physiology. Endocrinology and metabolism, 2006, Volume: 290, Issue:4 Topics: Adult; AMP-Activated Protein Kinases; Biopsy, Fine-Needle; Blood Glucose; Catecholamines; Energy Met	2006
Effects of purified oxygenated water on exercise performance during acute hypoxic exposure. International journal of sport nutrition and exercise metabolism, 2005, Volume: 15, Issue:6 Topics: Administration, Oral; Adult; Altitude; Bicycling; Blood Gas Analysis; Body Weight; Cross-Over Studie	2005
Effects of exercise-induced arterial hypoxaemia on limb muscle fatigue and performance. Clinical and experimental pharmacology & physiology, 2006, Volume: 33, Issue:4 Topics: Adult; Arteries; Bicycling; Exercise; Humans; Hypoxia; Lactic Acid; Muscle Fatigue; Muscle, Skeletal	2006
Effects of hypoxia on the onset of muscle deoxygenation and the lactate threshold. The journal of physiological sciences : JPS, 2006, Volume: 56, Issue:4 Topics: Adult; Exercise; Female; Humans; Hypoxia; Lactic Acid; Male; Muscles; Oxygen; Oxygen Consumption; Sp	2006
The effects of hyperthermia and hypoxia on ventilation during low-intensity steady-state exercise. American journal of physiology. Regulatory, integrative and comparative physiology, 2007, Volume: 292, Issue:1 Topics: Adult; Body Temperature; Chemoreceptor Cells; Ergometry; Exercise; Fever; Hemoglobins; Humans; Hypox	2007
The influence of acute and 23 days of intermittent hypoxic exposures on the exercise-induced forehead sweating response. European journal of applied physiology, 2007, Volume: 99, Issue:5 Topics: Acclimatization; Acute Disease; Adult; Altitude; Blood Pressure; Body Temperature Regulation; Chroni	2007
Adjusting oxygen fraction to avoid hyperoxemia during cardiopulmonary bypass. Asian cardiovascular & thoracic annals, 2007, Volume: 15, Issue:4 Topics: Administration, Inhalation; Blood Gas Analysis; Carbon Dioxide; Cardiopulmonary Bypass; Coronary Art	2007
Does poor oxygenation during one-lung ventilation impair aerobic myocardial metabolism in patients with symptomatic coronary artery disease? Interactive cardiovascular and thoracic surgery, 2007, Volume: 6, Issue:2 Topics: Aged; Anaerobic Threshold; Cardiopulmonary Bypass; Coronary Artery Bypass; Coronary Artery Disease;	2007
GXT responses in altitude-acclimatized cyclists during sea-level simulation. Medicine and science in sports and exercise, 2007, Volume: 39, Issue:10 Topics: Acclimatization; Adult; Altitude; Bicycling; Colorado; Exercise; Exercise Test; Exhalation; Female;	2007
The effect of intermittent hypobaric hypoxic exposure and sea level training on submaximal economy in well-trained swimmers and runners. Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 104, Issue:2 Topics: Acclimatization; Adult; Altitude; Double-Blind Method; Exercise; Female; Heart Rate; Humans; Hypoxia	2008
Improved running economy and increased hemoglobin mass in elite runners after extended moderate altitude exposure. Journal of science and medicine in sport, 2009, Volume: 12, Issue:1 Topics: Altitude; Australia; Biomechanical Phenomena; Heart Rate; Hemoglobins; Humans; Hypoxia; Lactic Acid;	2009
[Young football players aerobic perfomance in sub-maximum exercise with exhaustion at a moderate altitude without acclimation: experience in El Condor]. Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina), 2007, Volume: 64, Issue:1 Topics: Acclimatization; Adolescent; Altitude; Anaerobic Threshold; Argentina; Biomarkers; Blood Glucose; Bo	2007
The ventilation, lactate and electromyographic thresholds during incremental exercise tests in normoxia, hypoxia and hyperoxia. European journal of applied physiology and occupational physiology, 1994, Volume: 69, Issue:2 Topics: Adult; Anaerobic Threshold; Blood Gas Analysis; Carbon Dioxide; Chemoreceptor Cells; Electromyograph	1994
Gas exchange, blood lactate, and plasma catecholamines during incremental exercise in hypoxia and normoxia. Journal of applied physiology (Bethesda, Md. : 1985), 1995, Volume: 79, Issue:4 Topics: Adult; Catecholamines; Exercise; Humans; Hypoxia; Lactates; Lactic Acid; Male; Oxygen Consumption; P	1995
Effect of inspired O2 concentration on leg lactate release during incremental exercise. Journal of applied physiology (Bethesda, Md. : 1985), 1996, Volume: 81, Issue:1 Topics: Adult; Exercise; Exercise Test; Humans; Hypoxia; Lactic Acid; Leg; Male; Muscle, Skeletal; Oxygen Co	1996
The effect of altitude hypoxia on glucose homeostasis in men. The Journal of physiology, 1997, Oct-01, Volume: 504 ( Pt 1) Topics: Acclimatization; Adult; Altitude Sickness; Catecholamines; Exercise; Glucose; Glucose Clamp Techniqu	1997
The serum interleukin 8 level reflects hepatic mitochondrial redox state in hyperthermochemohypoxic isolated liver perfusion with use of a venovenous bypass. Surgery, 1999, Volume: 125, Issue:3 Topics: Aged; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Combined Modality Therapy; Fe	1999
Intermittent hypobaric hypoxia induces altitude acclimation and improves the lactate threshold. Aviation, space, and environmental medicine, 2000, Volume: 71, Issue:2 Topics: Acclimatization; Adult; Altitude Sickness; Anaerobic Threshold; Erythrocyte Count; Erythrocyte Indic	2000
Effect of acute hypoxia on vasopressin release and intravascular fluid during dynamic exercise in humans. American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 279, Issue:1 Topics: Acute Disease; Adult; Arginine Vasopressin; Blood Gas Analysis; Blood Pressure; Body Water; Body Wei	2000
Low-dose prostacyclin in treatment of severe brain trauma evaluated with microdialysis and jugular bulb oxygen measurements. Acta anaesthesiologica Scandinavica, 2000, Volume: 44, Issue:7 Topics: Adult; Aged; Biomarkers; Brain Injuries; Energy Metabolism; Epoprostenol; Female; Humans; Hypoxia; J	2000
Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia. American journal of physiology. Endocrinology and metabolism, 2000, Volume: 279, Issue:4 Topics: Acetyl Coenzyme A; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Adult; Bl	2000
Impaired interval exercise responses in elite female cyclists at moderate simulated altitude. Journal of applied physiology (Bethesda, Md. : 1985), 2000, Volume: 89, Issue:5 Topics: Acids; Altitude; Bicarbonates; Bicycling; Double-Blind Method; Exercise Test; Female; Heart Rate; Hu	2000
Physical exercise and normobaric hypoxia: independent modulators of peripheral cholecystokinin metabolism in man. Journal of applied physiology (Bethesda, Md. : 1985), 2001, Volume: 90, Issue:1 Topics: Adult; Amino Acids, Branched-Chain; Anthropometry; Atmospheric Pressure; Blood Glucose; Cholecystoki	2001
Physical training with and without oxygen in patients with chronic obstructive pulmonary disease and exercise-induced hypoxaemia. Journal of rehabilitation medicine, 2001, Volume: 33, Issue:5 Topics: Aged; Carbon Dioxide; Exercise; Exercise Test; Exercise Therapy; Female; Humans; Hypoxia; Lactic Aci	2001
Increases in maximal accumulated oxygen deficit after high-intensity interval training are not gender dependent. Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 92, Issue:5 Topics: Adult; Body Composition; Body Height; Body Weight; Exercise; Exercise Test; Female; Heart Rate; Huma	2002
The effect of sodium citrate intake on anaerobic performance in normoxia and after sudden ascent to a moderate altitude. The Journal of sports medicine and physical fitness, 2002, Volume: 42, Issue:2 Topics: Adult; Altitude; Anaerobic Threshold; Citrates; Double-Blind Method; Exercise; Heart Rate; Humans; H	2002
The influence of pacing strategy on VO2 and supramaximal kayak performance. Medicine and science in sports and exercise, 2002, Volume: 34, Issue:6 Topics: Adolescent; Adult; Competitive Behavior; Exercise; Humans; Hydrogen-Ion Concentration; Hypoxia; Lact	2002
Exercise-induced oxyhaemoglobin desaturation, ventilatory limitation and lung diffusing capacity in women during and after exercise. European journal of applied physiology, 2002, Volume: 87, Issue:2 Topics: Adult; Arteries; Exercise; Exercise Test; Female; Humans; Hypoxia; Lactic Acid; Lung Volume Measurem	2002
Metabolic aspects of acute tissue hypoxia during extracorporeal circulation and their modification induced by L-carnitine treatment. International journal of clinical pharmacology research, 1992, Volume: 12, Issue:3 Topics: Bicarbonates; Carnitine; Double-Blind Method; Extracorporeal Circulation; Female; Fumarates; Humans;	1992
Effect of hypoxia on psychomotor performance during graded exercise. Aviation, space, and environmental medicine, 1991, Volume: 62, Issue:3 Topics: Adult; Exercise; Heart Rate; Humans; Hypoxia; Lactates; Lactic Acid; Psychomotor Performance	1991
Effect of dichloroacetate on ventilatory response to sustained hypoxia in normal adults. Respiration physiology, 1990, Volume: 82, Issue:1 Topics: Adult; Brain; Dichloroacetic Acid; Female; Humans; Hypoxia; Lactates; Lactic Acid; Male; Respiration	1990

lactic acid and Anoxemia

Research Excerpts

Research

Studies (912)

Authors

Clinical Trials (21)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Jones, AK	1
Rozance, PJ	2
Brown, LD	2
Lorca, RA	1
Julian, CG	1
Moore, LG	1
Limesand, SW	3
Wesolowski, SR	1
Flores-Sauceda, M	1
Camacho-Jiménez, L	1
Peregrino-Uriarte, AB	1
Leyva-Carrillo, L	1
Arvizu-Flores, A	1
Yepiz-Plascencia, G	1
Dennis, MC	1
Goods, PSR	1
Binnie, MJ	1
Girard, O	4
Wallman, KE	1
Dawson, B	3
Billaut, F	2
Peeling, P	3
Yamagata, K	2
Zúñiga, A	1
Camacho, M	1
Chang, HJ	1
Fristot, E	1
Mayonove, P	1
Hani, EH	1
Bonnet, J	1
Beamer, ZG	1
Routray, P	1
Choi, WG	2
Spangler, MK	1
Lokdarshi, A	1
Roberts, DM	2
Huynh, KW	1
Pamenter, ME	1
Wang, CY	1
Hsieh, MK	1