lactic acid has been researched along with Angiogenesis, Pathologic in 100 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To develop thalidomide-loaded poly-lactide-co-glycolide implants and evaluate its in vivo release and biological activity against inflammation and angiogenesis after subcutaneous administration." | 7.81 | Development of thalidomide-loaded biodegradable devices and evaluation of the effect on inhibition of inflammation and angiogenesis after subcutaneous application. ( Andrade, SP; Batista, LF; da Nova Mussel, W; da Silva, GR; de Souza, PA; Fialho, SL; Pereira, BG; Serakides, R; Silva-Cunha, A, 2015) |
| "The aim was to evaluate tetraiodothyroacetic acid (tetrac), a thyroid hormone analog of L-thyroxin, conjugated to poly(lactic-co-glycolic acid) nanoparticles (T-PLGA-NPs) both in vitro and in vivo for the treatment of drug-resistant breast cancer." | 7.79 | Tetraiodothyroacetic acid-conjugated PLGA nanoparticles: a nanomedicine approach to treat drug-resistant breast cancer. ( Bharali, DJ; Davis, PJ; Mousa, SA; Yalcin, M, 2013) |
| "Poly(lactic-co-glycolic acid) microspheres loaded with imatinib mesylate has been developed as a new therapeutic strategy to prevent craniopharyngioma recurrence." | 7.79 | Controlled release of imatinib mesylate from PLGA microspheres inhibit craniopharyngioma mediated angiogenesis. ( Akgun, E; Avsar, T; Baysal, K; Karal-Yilmaz, O; Kilic, T; Kukut, M; Ozkan, A, 2013) |
| "Temozolomide (TM) has anti-tumor activity in patients with malignant glioma." | 7.76 | Temozolomide/PLGA microparticles plus vatalanib inhibits tumor growth and angiogenesis in an orthotopic glioma model. ( Liu, JM; Tang, GS; Wang, Y; Yue, ZJ; Zhang, H; Zhang, YH, 2010) |
| " Approaches that can decrease the overall dose of curcumin (for example, by increasing its potency or reducing its clearance rate) may allow the development of sustained release curcumin dosage forms as a practical approach to cancer chemoprevention." | 5.48 | Chemopreventive efficacy of curcumin-loaded PLGA microparticles in a transgenic mouse model of HER-2-positive breast cancer. ( Grill, AE; Koniar, B; Panyam, J; Shahani, K, 2018) |
| "In this study, we generated and characterized hyaluronate-PEG-Chitosan-Lactate (H-PCL) nanoparticles (NPs) to simultaneously deliver IL6-specific siRNA and BV6 to 4T1 (breast cancer) and CT26 (colon cancer) cells, and investigate the anti-tumor properties of this combination therapy both in vitro and in vivo." | 3.96 | Codelivery of BV6 and anti-IL6 siRNA by hyaluronate-conjugated PEG-chitosan-lactate nanoparticles inhibits tumor progression. ( Ahmadi, A; Boroumand-Noughabi, S; Hassannia, H; Heydari, M; Hojjat-Farsangi, M; Izadi, S; Jadidi-Niaragh, F; Karoon Kiani, F; Keramati, MR; Masjedi, A; Mohammadi, H; Sadat Eshaghi, F; Salimifard, S; Shahdadnejad, K, 2020) |
| "To develop thalidomide-loaded poly-lactide-co-glycolide implants and evaluate its in vivo release and biological activity against inflammation and angiogenesis after subcutaneous administration." | 3.81 | Development of thalidomide-loaded biodegradable devices and evaluation of the effect on inhibition of inflammation and angiogenesis after subcutaneous application. ( Andrade, SP; Batista, LF; da Nova Mussel, W; da Silva, GR; de Souza, PA; Fialho, SL; Pereira, BG; Serakides, R; Silva-Cunha, A, 2015) |
| "The aim was to evaluate tetraiodothyroacetic acid (tetrac), a thyroid hormone analog of L-thyroxin, conjugated to poly(lactic-co-glycolic acid) nanoparticles (T-PLGA-NPs) both in vitro and in vivo for the treatment of drug-resistant breast cancer." | 3.79 | Tetraiodothyroacetic acid-conjugated PLGA nanoparticles: a nanomedicine approach to treat drug-resistant breast cancer. ( Bharali, DJ; Davis, PJ; Mousa, SA; Yalcin, M, 2013) |
| "Poly(lactic-co-glycolic acid) microspheres loaded with imatinib mesylate has been developed as a new therapeutic strategy to prevent craniopharyngioma recurrence." | 3.79 | Controlled release of imatinib mesylate from PLGA microspheres inhibit craniopharyngioma mediated angiogenesis. ( Akgun, E; Avsar, T; Baysal, K; Karal-Yilmaz, O; Kilic, T; Kukut, M; Ozkan, A, 2013) |
| "Temozolomide (TM) has anti-tumor activity in patients with malignant glioma." | 3.76 | Temozolomide/PLGA microparticles plus vatalanib inhibits tumor growth and angiogenesis in an orthotopic glioma model. ( Liu, JM; Tang, GS; Wang, Y; Yue, ZJ; Zhang, H; Zhang, YH, 2010) |
| "The combination of peritoneal exposure to dialysis fluids and administration of zopolrestat, a newly developed inhibitor of aldose reductase activity, resulted in less fibrosis and fewer peritoneal vessels than exposure to dialysis fluids only, in a long-term exposure model in the rat." | 3.73 | Effects of inhibition of the polyol pathway during chronic peritoneal exposure to a dialysis solution. ( Aberra, M; Aten, J; Deira, G; Dragt, CA; Krediet, RT; van Westrhenen, R, 2005) |
| "Thus, augmenting anticancer immune responses by lactate metabolism inhibition may modify lactate levels in the tumor microenvironment." | 2.82 | Tumor Microenvironment: Lactic Acid Promotes Tumor Development. ( Gao, Y; Liu, G; Shang, A; Wu, J; Yuan, Y; Zhou, H, 2022) |
| "In the autocrine pathway, cancer cell-generated lactate activates GPR81 on cancer cells; in the paracrine pathway, cancer cell-generated lactate activates GPR81 on immune cells, endothelial cells, and adipocytes present in tumor stroma." | 2.66 | Lactate/GPR81 signaling and proton motive force in cancer: Role in angiogenesis, immune escape, nutrition, and Warburg phenomenon. ( Brown, TP; Ganapathy, V, 2020) |
| "Lactate-producing ('lactagenic') cancer cells are characterized by increased aerobic glycolysis and excessive lactate formation, a phenomenon described by Otto Warburg 93 years ago, which still remains unexplained." | 2.55 | Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect. ( Brooks, GA; San-Millán, I, 2017) |
| "This occurs because cancer also uses glycolysis, which does not need oxygen or arteries." | 2.50 | ALPHA glycolytic vasculogenesis better correlates with MRI and CT imaging techniques than the traditional oxygen vasculogenesis theory. ( Haaga, JR; Haaga, R; Love, Z; Moulter, J; Patel, I, 2014) |
| "However, in tumors a high number of macrophages persists and might contribute to the ongoing growth, neovascularization, and metastasis of malignant cells." | 2.41 | Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors. ( Bishop, ET; Brown, NJ; Crowther, M; Lewis, CE, 2001) |
| " Approaches that can decrease the overall dose of curcumin (for example, by increasing its potency or reducing its clearance rate) may allow the development of sustained release curcumin dosage forms as a practical approach to cancer chemoprevention." | 1.48 | Chemopreventive efficacy of curcumin-loaded PLGA microparticles in a transgenic mouse model of HER-2-positive breast cancer. ( Grill, AE; Koniar, B; Panyam, J; Shahani, K, 2018) |
| "Primary tumor growth, metastasis formation and TME phenotype were significantly different in LDH-A KD tumors compared with controls." | 1.48 | LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response. ( Blasberg, R; Cohen, IJ; Khanin, R; Koutcher, JA; Maeda, M; Mane, M; Moroz, E; Satagopan, J; Serganova, I; Shindo, M; Vemuri, K, 2018) |
| "Unearthing embryology-like processes in tumors may allow us to control organ-like tumor features such as tissue repair and revascularization and treat intratumoral heterogeneity." | 1.46 | Metabolic origins of spatial organization in the tumor microenvironment. ( Akkari, L; Carmona-Fontaine, C; Deforet, M; Joyce, JA; Thompson, CB; Xavier, JB, 2017) |
| "Here, GPR81 expression in breast cancer patients and several breast cancer cell lines was significantly increased compared with normal mammary tissues and cells." | 1.43 | G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion. ( Heo, K; Lee, YJ; Noh, DY; Park, KS; Park, S; Park, SA; Ryu, SH; Seo, YK; Shin, KJ; Suh, PG, 2016) |
| " It was determined that: a) all three TRMs are required for maximum promotion of angiogenesis, blood vessel maturation and prevention of the FBR; b) VEGF has to be administered at higher doses than PDGF; c) an increase in dexamethasone dosing must be accompanied by a proportional increase in growth factor dosing; and d) modification of the TRM ratio can achieve a constant capillary density throughout the implantation period which is important for applications such as biosensors to maintain sensitivity and a stable sensor baseline." | 1.42 | Multiple tissue response modifiers to promote angiogenesis and prevent the foreign body reaction around subcutaneous implants. ( Burgess, DJ; Kastellorizios, M; Papadimitrakopoulos, F, 2015) |
| "BxPC-3 pancreatic cancer cells were cultured under hypoxic conditions and treated with or without the nanoparticles." | 1.42 | PLGA/poloxamer nanoparticles loaded with EPAS1 siRNA for the treatment of pancreatic cancer in vitro and in vivo. ( Fang, W; Li, K; Li, L; Pan, X; Sun, Y; Zhao, Z; Zhu, Q; Zhu, Y; Zuo, J, 2015) |
| "Recent studies have suggested that cancer cells behave as metabolic parasites, by inducing oxidative stress in adjacent normal fibroblasts." | 1.38 | Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth. ( Ando', S; Aquila, S; Casimiro, MC; Guido, C; Howell, A; Lin, Z; Lisanti, MP; Martinez-Outschoorn, UE; Pestell, RG; Sotgia, F; Whitaker-Menezes, D; Zimmers, TA, 2012) |
| "Conversely, we generated human breast cancer cells (MDA-MB-231 cells) overexpressing CDK inhibitors, namely p16(INK4A) or p21(WAF1/CIP1)." | 1.38 | CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis. ( Andò, S; Capparelli, C; Chiavarina, B; Howell, A; Hulit, J; Lisanti, MP; Martinez-Outschoorn, UE; Pestell, RG; Pestell, TG; Sotgia, F; Whitaker-Menezes, D, 2012) |
| " In this study, we aimed to investigate the effect of PLGA nanoparticles encapsulating hPNAS-4 combined with cisplatin (DDP) on ovarian carcinoma." | 1.37 | Antitumor effects of PLGA nanoparticles encapsulating the human PNAS-4 gene combined with cisplatin in ovarian cancer. ( Bai, Y; Li, S; Liu, P; Qi, X; Song, X; Sun, C; Wei, Y; Xie, C; Yi, T; Zhao, X; Zheng, Y, 2011) |
| "Antiangiogenic cancer therapy can be achieved through the targeted delivery of antiangiogenic agents to the endothelial cells of tumor neovasculature." | 1.36 | Peptide-conjugated biodegradable nanoparticles as a carrier to target paclitaxel to tumor neovasculature. ( Chen, HZ; Fang, C; Lu, Q; Xie, J; Yu, DH, 2010) |
| "Treatment with curcumin microparticles resulted in diminished vascular endothelial growth factor expression and poorly developed tumor microvessels, indicating a significant effect on tumor angiogenesis." | 1.36 | Injectable sustained release microparticles of curcumin: a new concept for cancer chemoprevention. ( Blum, A; Freeman, D; Ma, L; Panyam, J; Shahani, K; Swaminathan, SK, 2010) |
| "Colon carcinoma is one of the common malignant tumors and has high morbidity and mortality in the world." | 1.36 | The pigment epithelial-derived factor gene loaded in PLGA nanoparticles for therapy of colon carcinoma. ( Cui, FY; Li, SZ; Li, ZY; Mao, YQ; Mu, B; Song, XR; Wei, YQ; Yang, L, 2010) |
| "Renal cell carcinoma is the most lethal of the common urologic malignancies, with no available effective therapeutics." | 1.35 | Tetraidothyroacetic acid (tetrac) and tetrac nanoparticles inhibit growth of human renal cell carcinoma xenografts. ( Bharali, DJ; Davis, FB; Davis, PJ; Dyskin, E; Hercbergs, A; Lansing, L; Mousa, SA; Mousa, SS; Yalcin, M, 2009) |
| "In mice injected with B16 melanoma cells, the sustained IL-1Ra delivery from biodegradable microspheres inhibited tumor growth and significantly prolonged mice survival." | 1.34 | Sustained delivery of IL-1 Ra from biodegradable microspheres reduces the number of murine B16 melanoma lung metastases. ( Apte, RN; Cohen, S; Dinarello, CA; Lavi, G; Voronov, E, 2007) |
| "Fibrin has been extensively studied as an adhesive in plastic and reconstructive surgery and the enhancement of wound healing with embedded growth factors is desirable." | 1.32 | Incorporation of polymer microspheres within fibrin scaffolds for the controlled delivery of FGF-1. ( Askari, M; Marra, KG; Royce, SM, 2004) |
| "AIDS-related Kaposi's sarcoma (AIDS-KS), the most prevalent HIV-associated malignancy, is a debilitating, potentially fatal disease." | 1.31 | Sustained angiogenesis enables in vivo transplantation of mucocutaneous derived AIDS-related Kaposi's sarcoma cells in murine hosts. ( Kang, J; Mallery, SR; Ness, GM; Pei, P; Schwendeman, SP; Zhu, G, 2000) |
| "Lactic acid promotes the proliferation of other mesenchymal cells as well." | 1.27 | The role of increased lactic acid concentration in neovascularizations. ( Imre, G, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (5.00) | 18.7374 |
| 1990's | 7 (7.00) | 18.2507 |
| 2000's | 14 (14.00) | 29.6817 |
| 2010's | 64 (64.00) | 24.3611 |
| 2020's | 10 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shen, HX | 1 |
| Liu, JZ | 1 |
| Yan, XQ | 1 |
| Yang, HN | 1 |
| Hu, SQ | 1 |
| Yan, XL | 1 |
| Xu, T | 1 |
| El Haj, AJ | 1 |
| Yang, Y | 2 |
| Lü, LX | 1 |
| Gao, Y | 2 |
| Zhou, H | 1 |
| Liu, G | 1 |
| Wu, J | 1 |
| Yuan, Y | 1 |
| Shang, A | 1 |
| Zhu, D | 1 |
| Jiang, Y | 1 |
| Cao, H | 1 |
| Yang, J | 2 |
| Shu, Y | 1 |
| Feng, H | 1 |
| Yang, X | 2 |
| Sun, X | 1 |
| Shao, M | 1 |
| Singh, S | 1 |
| Pandey, S | 1 |
| Chawla, AS | 1 |
| Bhatt, AN | 1 |
| Roy, BG | 1 |
| Saluja, D | 1 |
| Dwarakanath, BS | 1 |
| Brown, TP | 1 |
| Ganapathy, V | 1 |
| Zhang, J | 1 |
| Xue, W | 1 |
| Xu, K | 1 |
| Yi, L | 1 |
| Guo, Y | 1 |
| Xie, T | 1 |
| Tong, H | 1 |
| Zhou, B | 1 |
| Wang, S | 1 |
| Li, Q | 2 |
| Liu, H | 1 |
| Chen, X | 2 |
| Fang, J | 1 |
| Zhang, W | 1 |
| Tang, J | 1 |
| Meka, AK | 1 |
| Theivendran, S | 1 |
| Wang, Y | 4 |
| Song, H | 1 |
| Fu, J | 1 |
| Ban, W | 1 |
| Gu, Z | 1 |
| Lei, C | 1 |
| Li, S | 4 |
| Yu, C | 1 |
| Salimifard, S | 1 |
| Karoon Kiani, F | 1 |
| Sadat Eshaghi, F | 1 |
| Izadi, S | 1 |
| Shahdadnejad, K | 1 |
| Masjedi, A | 1 |
| Heydari, M | 1 |
| Ahmadi, A | 1 |
| Hojjat-Farsangi, M | 1 |
| Hassannia, H | 1 |
| Mohammadi, H | 1 |
| Boroumand-Noughabi, S | 1 |
| Keramati, MR | 1 |
| Jadidi-Niaragh, F | 1 |
| Abdali, A | 1 |
| Baci, D | 1 |
| Damiani, I | 1 |
| Belloni, F | 1 |
| De Dominicis, C | 1 |
| Gelmi, ML | 1 |
| Corsini, A | 1 |
| Bellosta, S | 1 |
| Huang, J | 2 |
| Zhao, X | 4 |
| Li, X | 1 |
| Peng, J | 1 |
| Yang, W | 1 |
| Mi, S | 1 |
| Reuss, AM | 1 |
| Groos, D | 1 |
| Buchfelder, M | 1 |
| Savaskan, N | 1 |
| Grill, AE | 1 |
| Shahani, K | 2 |
| Koniar, B | 1 |
| Panyam, J | 2 |
| Ban, HS | 1 |
| Kim, BK | 1 |
| Lee, H | 1 |
| Kim, HM | 1 |
| Harmalkar, D | 1 |
| Nam, M | 1 |
| Park, SK | 1 |
| Lee, K | 2 |
| Park, JT | 1 |
| Kim, I | 1 |
| Hwang, GS | 1 |
| Won, M | 1 |
| Leung, E | 1 |
| Cairns, RA | 1 |
| Chaudary, N | 1 |
| Vellanki, RN | 1 |
| Kalliomaki, T | 1 |
| Moriyama, EH | 1 |
| Mujcic, H | 1 |
| Wilson, BC | 1 |
| Wouters, BG | 1 |
| Hill, R | 1 |
| Milosevic, M | 1 |
| Voss, DM | 1 |
| Spina, R | 1 |
| Carter, DL | 1 |
| Lim, KS | 1 |
| Jeffery, CJ | 1 |
| Bar, EE | 1 |
| Miranda-Gonçalves, V | 1 |
| Bezerra, F | 1 |
| Costa-Almeida, R | 1 |
| Freitas-Cunha, M | 1 |
| Soares, R | 1 |
| Martinho, O | 1 |
| Reis, RM | 1 |
| Pinheiro, C | 1 |
| Baltazar, F | 1 |
| Bhattacharya, R | 1 |
| Ray Chaudhuri, S | 1 |
| Roy, SS | 1 |
| Serganova, I | 1 |
| Cohen, IJ | 1 |
| Vemuri, K | 1 |
| Shindo, M | 1 |
| Maeda, M | 1 |
| Mane, M | 1 |
| Moroz, E | 1 |
| Khanin, R | 1 |
| Satagopan, J | 1 |
| Koutcher, JA | 1 |
| Blasberg, R | 1 |
| Nasir Kansestani, A | 1 |
| Mansouri, K | 1 |
| Hemmati, S | 1 |
| Zare, ME | 1 |
| Moatafaei, A | 1 |
| Lu, J | 1 |
| Liang, X | 3 |
| Fu, G | 1 |
| Shen, Q | 1 |
| Bharali, DJ | 3 |
| Yalcin, M | 3 |
| Davis, PJ | 3 |
| Mousa, SA | 3 |
| Zou, L | 2 |
| Song, X | 3 |
| Yi, T | 3 |
| Deng, H | 1 |
| Li, Z | 1 |
| Bai, Y | 2 |
| Zhong, Q | 1 |
| Wei, Y | 3 |
| Mathews, EH | 1 |
| Liebenberg, L | 1 |
| Haaga, JR | 2 |
| Haaga, R | 2 |
| Liu, P | 2 |
| Duan, Y | 1 |
| Yin, X | 1 |
| Wang, Q | 1 |
| Liu, X | 2 |
| Wang, X | 1 |
| Zhou, J | 1 |
| Wang, W | 1 |
| Qiu, L | 1 |
| Di, W | 1 |
| Disanzo, BL | 1 |
| You, T | 1 |
| Kang, T | 1 |
| Gao, X | 1 |
| Hu, Q | 1 |
| Jiang, D | 1 |
| Feng, X | 1 |
| Zhang, X | 2 |
| Song, Q | 1 |
| Yao, L | 1 |
| Huang, M | 1 |
| Jiang, X | 1 |
| Pang, Z | 1 |
| Chen, H | 1 |
| Chen, J | 1 |
| El Sayed, SM | 1 |
| Mohamed, WG | 1 |
| Seddik, MA | 1 |
| Ahmed, AS | 1 |
| Mahmoud, AG | 1 |
| Amer, WH | 1 |
| Helmy Nabo, MM | 1 |
| Hamed, AR | 1 |
| Ahmed, NS | 1 |
| Abd-Allah, AA | 1 |
| Xu, Y | 1 |
| An, X | 1 |
| Guo, X | 1 |
| Habtetsion, TG | 1 |
| Xu, X | 1 |
| Kandala, S | 1 |
| Li, H | 1 |
| Zhang, C | 1 |
| Caldwell, RB | 1 |
| Fulton, DJ | 1 |
| Su, Y | 1 |
| Hoda, MN | 1 |
| Zhou, G | 1 |
| Wu, C | 1 |
| Huo, Y | 1 |
| Nasr, M | 1 |
| Nafee, N | 1 |
| Saad, H | 1 |
| Kazem, A | 1 |
| Patel, I | 1 |
| Love, Z | 1 |
| Moulter, J | 1 |
| Chang, J | 1 |
| Jung, HJ | 1 |
| Jeong, SH | 1 |
| Kim, HK | 1 |
| Han, J | 1 |
| Kwon, HJ | 1 |
| Pan, X | 1 |
| Zhu, Q | 1 |
| Sun, Y | 1 |
| Li, L | 1 |
| Zhu, Y | 1 |
| Zhao, Z | 1 |
| Zuo, J | 1 |
| Fang, W | 1 |
| Li, K | 1 |
| Ramazani, F | 1 |
| Hiemstra, C | 1 |
| Steendam, R | 1 |
| Kazazi-Hyseni, F | 1 |
| Van Nostrum, CF | 1 |
| Storm, G | 1 |
| Kiessling, F | 1 |
| Lammers, T | 1 |
| Hennink, WE | 1 |
| Kok, RJ | 1 |
| Lee, DC | 1 |
| Sohn, HA | 1 |
| Park, ZY | 1 |
| Oh, S | 1 |
| Kang, YK | 1 |
| Lee, KM | 1 |
| Kang, M | 1 |
| Jang, YJ | 1 |
| Yang, SJ | 1 |
| Hong, YK | 1 |
| Noh, H | 1 |
| Kim, JA | 1 |
| Kim, DJ | 1 |
| Bae, KH | 1 |
| Kim, DM | 1 |
| Chung, SJ | 1 |
| Yoo, HS | 1 |
| Yu, DY | 1 |
| Park, KC | 1 |
| Yeom, YI | 1 |
| Pereira, BG | 1 |
| Batista, LF | 1 |
| de Souza, PA | 1 |
| da Silva, GR | 1 |
| Andrade, SP | 1 |
| Serakides, R | 1 |
| da Nova Mussel, W | 1 |
| Silva-Cunha, A | 1 |
| Fialho, SL | 1 |
| Du, Y | 2 |
| Zhang, Q | 2 |
| Jing, L | 2 |
| Chi, C | 2 |
| Li, Y | 2 |
| Dai, Z | 2 |
| Tian, J | 2 |
| Kastellorizios, M | 1 |
| Papadimitrakopoulos, F | 1 |
| Burgess, DJ | 1 |
| Singh, M | 1 |
| Bhatnagar, P | 1 |
| Mishra, S | 1 |
| Kumar, P | 1 |
| Shukla, Y | 1 |
| Gupta, KC | 1 |
| Tonello, S | 1 |
| Moore, MC | 1 |
| Sharma, B | 1 |
| Dobson, J | 1 |
| McFetridge, PS | 1 |
| Lau, JY | 1 |
| Chen, AP | 1 |
| Gu, YP | 1 |
| Cunningham, CH | 1 |
| Lee, YJ | 1 |
| Shin, KJ | 1 |
| Park, SA | 1 |
| Park, KS | 1 |
| Park, S | 1 |
| Heo, K | 1 |
| Seo, YK | 1 |
| Noh, DY | 1 |
| Ryu, SH | 1 |
| Suh, PG | 1 |
| San-Millán, I | 1 |
| Brooks, GA | 1 |
| Kaznatcheev, A | 1 |
| Vander Velde, R | 1 |
| Scott, JG | 1 |
| Basanta, D | 1 |
| Carmona-Fontaine, C | 1 |
| Deforet, M | 1 |
| Akkari, L | 1 |
| Thompson, CB | 1 |
| Joyce, JA | 1 |
| Xavier, JB | 1 |
| Verma, VK | 1 |
| Singh, V | 1 |
| Singh, MP | 1 |
| Singh, SM | 1 |
| Vargas, A | 1 |
| Delie, F | 1 |
| Schumann, P | 1 |
| Tavassol, F | 1 |
| Lindhorst, D | 1 |
| Stuehmer, C | 1 |
| Bormann, KH | 1 |
| Kampmann, A | 1 |
| Mülhaupt, R | 2 |
| Laschke, MW | 2 |
| Menger, MD | 2 |
| Gellrich, NC | 2 |
| Rücker, M | 2 |
| Grand, S | 1 |
| Pasquier, BM | 1 |
| Hoffmann, DM | 1 |
| Krainik, A | 1 |
| Ashraf, A | 1 |
| Tropres, IM | 1 |
| Dillworth, K | 1 |
| Le Bas, JF | 1 |
| Lansing, L | 2 |
| Dyskin, E | 2 |
| Mousa, SS | 2 |
| Hercbergs, A | 1 |
| Davis, FB | 2 |
| Koschwanez, HE | 1 |
| Reichert, WM | 1 |
| Klitzman, B | 1 |
| Yu, DH | 1 |
| Lu, Q | 1 |
| Xie, J | 1 |
| Fang, C | 1 |
| Chen, HZ | 1 |
| Ravindran, J | 1 |
| Nair, HB | 1 |
| Sung, B | 1 |
| Prasad, S | 1 |
| Tekmal, RR | 1 |
| Aggarwal, BB | 1 |
| Bridoux, A | 1 |
| Hercbergs, AH | 1 |
| Lin, HY | 1 |
| Glinsky, GV | 1 |
| Glinskii, A | 1 |
| Ma, J | 1 |
| Qi, X | 2 |
| Okamoto, Y | 1 |
| Murakawa, T | 1 |
| Wang, F | 1 |
| Oyama, O | 1 |
| Ohkawa, R | 1 |
| Yoshioka, K | 1 |
| Du, W | 1 |
| Sugimoto, N | 1 |
| Yatomi, Y | 1 |
| Takuwa, N | 1 |
| Takuwa, Y | 1 |
| Swaminathan, SK | 1 |
| Freeman, D | 1 |
| Blum, A | 1 |
| Ma, L | 1 |
| Cui, FY | 1 |
| Song, XR | 1 |
| Li, ZY | 1 |
| Li, SZ | 1 |
| Mu, B | 1 |
| Mao, YQ | 1 |
| Wei, YQ | 1 |
| Yang, L | 1 |
| Zhang, YH | 1 |
| Yue, ZJ | 1 |
| Zhang, H | 1 |
| Tang, GS | 1 |
| Liu, JM | 1 |
| Dafni, H | 1 |
| Larson, PE | 1 |
| Hu, S | 1 |
| Yoshihara, HA | 1 |
| Ward, CS | 1 |
| Venkatesh, HS | 1 |
| Wang, C | 1 |
| Vigneron, DB | 1 |
| Ronen, SM | 1 |
| Chen, ZK | 1 |
| Cai, MX | 1 |
| Lin, LW | 1 |
| Xue, ES | 1 |
| Wei, HF | 1 |
| Zhang, XJ | 1 |
| Ke, LM | 1 |
| Végran, F | 2 |
| Boidot, R | 1 |
| Michiels, C | 2 |
| Sonveaux, P | 4 |
| Feron, O | 4 |
| Paula, JS | 1 |
| Ribeiro, VR | 1 |
| Sampaio, RB | 1 |
| Mendonca, RJ | 1 |
| Haddad, A | 1 |
| Tedesco, AC | 1 |
| Coutinho-Netto, J | 1 |
| Haendchen, HA | 1 |
| Jorge, R | 1 |
| Xie, C | 1 |
| Zheng, Y | 1 |
| Sun, C | 1 |
| Chang, X | 1 |
| Wei, C | 1 |
| Chiavarina, B | 2 |
| Whitaker-Menezes, D | 5 |
| Martinez-Outschoorn, UE | 4 |
| Witkiewicz, AK | 1 |
| Birbe, R | 1 |
| Howell, A | 5 |
| Pestell, RG | 5 |
| Smith, J | 1 |
| Daniel, R | 1 |
| Sotgia, F | 5 |
| Lisanti, MP | 5 |
| Dhup, S | 2 |
| Dadhich, RK | 1 |
| Porporato, PE | 2 |
| Copetti, T | 2 |
| De Saedeleer, CJ | 2 |
| Verrax, J | 2 |
| Kennedy, KM | 1 |
| Moon, EJ | 1 |
| Danhier, P | 1 |
| Frérart, F | 1 |
| Gallez, B | 1 |
| Ribeiro, A | 1 |
| Dewhirst, MW | 1 |
| Tang, R | 1 |
| Chai, WM | 1 |
| Ying, W | 1 |
| Yang, GY | 1 |
| Xie, H | 1 |
| Liu, HQ | 1 |
| Chen, KM | 1 |
| Guido, C | 2 |
| Capparelli, C | 2 |
| Balliet, R | 1 |
| Lin, Z | 2 |
| Aquila, S | 2 |
| Andò, S | 2 |
| Martinez-Outschoorn, U | 1 |
| Zimmers, TA | 1 |
| Casimiro, MC | 1 |
| Ando', S | 1 |
| Carito, V | 1 |
| Bonuccelli, G | 1 |
| Caroleo, MC | 1 |
| Cione, E | 1 |
| Pestell, TG | 1 |
| Hulit, J | 1 |
| Harjes, U | 1 |
| Bensaad, K | 1 |
| Harris, AL | 1 |
| Karal-Yilmaz, O | 1 |
| Ozkan, A | 1 |
| Akgun, E | 1 |
| Kukut, M | 1 |
| Baysal, K | 1 |
| Avsar, T | 1 |
| Kilic, T | 1 |
| Polet, F | 1 |
| Ogata, S | 1 |
| Naito, T | 1 |
| Yorioka, N | 1 |
| Kiribayashi, K | 1 |
| Kuratsune, M | 1 |
| Kohno, N | 1 |
| Royce, SM | 1 |
| Askari, M | 1 |
| Marra, KG | 1 |
| van Westrhenen, R | 2 |
| Aten, J | 2 |
| Aberra, M | 1 |
| Dragt, CA | 1 |
| Deira, G | 1 |
| Krediet, RT | 2 |
| Junker, D | 1 |
| Carvalho, C | 1 |
| Schramm, A | 1 |
| Huang, KH | 1 |
| Liu, JH | 1 |
| Wang, LY | 1 |
| Zhu, ZH | 1 |
| Chen, QK | 1 |
| Min, J | 1 |
| Chen, RF | 1 |
| Lavi, G | 1 |
| Voronov, E | 1 |
| Dinarello, CA | 1 |
| Apte, RN | 1 |
| Cohen, S | 1 |
| Hajji, N | 1 |
| de Boer, OJ | 1 |
| Kunne, C | 1 |
| de Waart, DR | 1 |
| Voss, K | 1 |
| Jacob, W | 1 |
| Roth, K | 1 |
| Barnhill, RL | 1 |
| Ryan, TJ | 1 |
| Hunt, TK | 1 |
| Knighton, DR | 1 |
| Thakral, KK | 1 |
| Goodson, WH | 1 |
| Andrews, WS | 1 |
| Imre, G | 3 |
| Yanai, S | 1 |
| Okada, H | 1 |
| Saito, K | 1 |
| Kuge, Y | 1 |
| Misaki, M | 1 |
| Ogawa, Y | 1 |
| Toguchi, H | 1 |
| Sandramouli, S | 1 |
| Jaffery, N | 1 |
| Sood, NN | 1 |
| Sihota, R | 1 |
| Burt, HM | 1 |
| Jackson, JK | 1 |
| Bains, SK | 1 |
| Liggins, RT | 1 |
| Oktaba, AM | 1 |
| Arsenault, AL | 1 |
| Hunter, WL | 1 |
| Winet, H | 1 |
| Hollinger, JO | 1 |
| Mallery, SR | 1 |
| Pei, P | 1 |
| Kang, J | 1 |
| Zhu, G | 1 |
| Ness, GM | 1 |
| Schwendeman, SP | 1 |
| Oudega, M | 1 |
| Gautier, SE | 1 |
| Chapon, P | 1 |
| Fragoso, M | 1 |
| Bates, ML | 1 |
| Parel, JM | 1 |
| Bunge, MB | 1 |
| Crowther, M | 1 |
| Brown, NJ | 1 |
| Bishop, ET | 1 |
| Lewis, CE | 1 |
| Wintermantel, E | 1 |
| Cima, L | 1 |
| Schloo, B | 1 |
| Langer, R | 1 |
| Csonka, E | 1 |
| Burton, HW | 1 |
| Barclay, JK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Very Low Carbohydrate Diet to Glasgow Prognostic Score, Serum Lactate and TNF Alpha on Colorectal Cancer Patients With Best Supportive Care[NCT03221920] | 26 participants (Anticipated) | Interventional | 2017-08-05 | Not yet recruiting | |||
| Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)[NCT05120284] | Phase 2 | 40 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for lactic acid and Angiogenesis, Pathologic
| Article | Year |
|---|---|
Tumor Microenvironment: Lactic Acid Promotes Tumor Development.
Topics: Glycolysis; Humans; Lactic Acid; Neoplasms; Neovascularization, Pathologic; Tumor Microenvironment | 2022 |
Lactate/GPR81 signaling and proton motive force in cancer: Role in angiogenesis, immune escape, nutrition, and Warburg phenomenon.
Topics: Animals; Cancer-Associated Fibroblasts; Humans; Lactic Acid; Membrane Transport Proteins; Neoplasms; | 2020 |
The Acidic Brain-Glycolytic Switch in the Microenvironment of Malignant Glioma.
Topics: Animals; Brain; Brain Chemistry; Brain Neoplasms; Carbonic Anhydrases; Glioma; Glycolysis; Humans; H | 2021 |
Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study.
Topics: Acetaminophen; Adult; Carcinoma, Hepatocellular; Disease Progression; Drug Therapy, Combination; Enz | 2014 |
ALPHA glycolytic vasculogenesis better correlates with MRI and CT imaging techniques than the traditional oxygen vasculogenesis theory.
Topics: Animals; Computer Simulation; Female; Glycolysis; Humans; Lactic Acid; Magnetic Resonance Imaging; M | 2014 |
Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect.
Topics: Carcinogenesis; Glycolysis; Humans; Lactic Acid; Mitochondria; Neoplasms; Neovascularization, Pathol | 2017 |
Glycolysis and rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Autoantigens; Cell Differentiation; Cell Proliferation; Fructose-Bisphosphate | 2011 |
Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis.
Topics: Humans; Lactic Acid; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Neovascularization, Path | 2012 |
Endothelial cell metabolism and implications for cancer therapy.
Topics: Endothelial Cells; Glucose; Glycolysis; Humans; Lactic Acid; Neoplasms; Neovascularization, Patholog | 2012 |
Endothelial cell metabolism and tumour angiogenesis: glucose and glutamine as essential fuels and lactate as the driving force.
Topics: Angiogenesis Inhibitors; Endothelial Cells; Endothelium, Vascular; Glucose; Glutamine; Glycolysis; H | 2013 |
Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors.
Topics: Animals; Cell Hypoxia; Glucose; Growth Substances; Humans; Lactic Acid; Macrophages; Mice; Neoplasms | 2001 |
Angiogenic role of lactic acid in the mechanism of neovascularization.
Topics: Animals; Cells, Cultured; Cornea; DNA Replication; Endothelium, Vascular; Lactates; Lactic Acid; Neo | 1992 |
88 other studies available for lactic acid and Angiogenesis, Pathologic
| Article | Year |
|---|---|
Hydrostatic pressure stimulates the osteogenesis and angiogenesis of MSCs/HUVECs co-culture on porous PLGA scaffolds.
Topics: Animals; Coculture Techniques; Human Umbilical Vein Endothelial Cells; Humans; Hydrostatic Pressure; | 2022 |
Lactate: A regulator of immune microenvironment and a clinical prognosis indicator in colorectal cancer.
Topics: Colorectal Neoplasms; Humans; Lactic Acid; Neovascularization, Pathologic; Prognosis; Tumor Microenv | 2022 |
Dietary 2-deoxy-D-glucose impairs tumour growth and metastasis by inhibiting angiogenesis.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Angiogenesis Inhibitors; Animals; Antimetabolites; Ca | 2019 |
Dual inhibition of PFKFB3 and VEGF normalizes tumor vasculature, reduces lactate production, and improves chemotherapy in glioblastoma: insights from protein expression profiling and MRI.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bevacizumab; Brain; Brain Neopla | 2020 |
Openwork@Dendritic Mesoporous Silica Nanoparticles for Lactate Depletion and Tumor Microenvironment Regulation.
Topics: Angiogenesis Inhibitors; Animals; Anthraquinones; Antineoplastic Agents; Breast Neoplasms; Cell Line | 2020 |
Codelivery of BV6 and anti-IL6 siRNA by hyaluronate-conjugated PEG-chitosan-lactate nanoparticles inhibits tumor progression.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Chick Embryo; Chitosan; Colonic | 2020 |
In vitro angiogenesis inhibition with selective compounds targeting the key glycolytic enzyme PFKFB3.
Topics: Angiogenesis Inhibitors; Cells, Cultured; Humans; Lactic Acid; Monocarboxylic Acid Transporters; Mus | 2021 |
HMGCR inhibition stabilizes the glycolytic enzyme PKM2 to support the growth of renal cell carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Carrier Proteins; Cell Line, Tumor; Cell Prol | 2021 |
Chemopreventive efficacy of curcumin-loaded PLGA microparticles in a transgenic mouse model of HER-2-positive breast cancer.
Topics: Animals; Anticarcinogenic Agents; Breast Neoplasms; Cell Proliferation; Curcumin; Cytokines; Delayed | 2018 |
The novel hypoxia-inducible factor-1α inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth.
Topics: Adamantane; Animals; Antineoplastic Agents; Cell Proliferation; Colorectal Neoplasms; Cyclic AMP; Fe | 2017 |
Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors.
Topics: Adenosine Triphosphate; Animals; Biomarkers; Cell Line, Tumor; Disease Models, Animal; Energy Metabo | 2017 |
Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression.
Topics: Acriflavine; Animals; Basigin; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Disease | 2017 |
Monocarboxylate transporter 1 is a key player in glioma-endothelial cell crosstalk.
Topics: Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Culture Med | 2017 |
FGF9-induced ovarian cancer cell invasion involves VEGF-A/VEGFR2 augmentation by virtue of ETS1 upregulation and metabolic reprogramming.
Topics: Autocrine Communication; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cellular Reprogramming | 2018 |
LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Female; Gene Knockdown Techniques; Humans; Hypoxia-Indu | 2018 |
High Glucose-reduced Apoptosis in Human Breast Cancer Cells Is Mediated by Activation of NF-κB.
Topics: Apoptosis; Breast Neoplasms; Cell Proliferation; Female; Glucose; Humans; Lactic Acid; MCF-7 Cells; | 2019 |
Hexokinase2 controls angiogenesis in melanoma by promoting aerobic glycolysis and activating the p38-MAPK signaling.
Topics: Apoptosis; Caspase 3; Caspase 9; Endostatins; Endothelial Cells; Glycolysis; Hexokinase; Human Umbil | 2019 |
Tetraiodothyroacetic acid-conjugated PLGA nanoparticles: a nanomedicine approach to treat drug-resistant breast cancer.
Topics: Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Doxo | 2013 |
Administration of PLGA nanoparticles carrying shRNA against focal adhesion kinase and CD44 results in enhanced antitumor effects against ovarian cancer.
Topics: Animals; Apoptosis; Cell Proliferation; Female; Focal Adhesion Protein-Tyrosine Kinases; Gene Knockd | 2013 |
Cancer control via glucose and glutamine deprivation.
Topics: Endothelium, Vascular; Glucose; Glutamine; Humans; Lactic Acid; Neoplasms; Neovascularization, Patho | 2013 |
Acidic lactate sequentially induced lymphogenesis, phlebogenesis, and arteriogenesis (ALPHA) hypothesis: Lactate-triggered glycolytic vasculogenesis that occurs in normoxia or hypoxia and complements the traditional concept of hypoxia-based vasculogenesis
Topics: Fibroblast Growth Factor 2; Glycolysis; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; | 2013 |
Specific cell targeting with APRPG conjugated PEG-PLGA nanoparticles for treating ovarian cancer.
Topics: Angiogenesis Inhibitors; Animals; Cyclohexanes; Drug Delivery Systems; Female; Human Umbilical Vein | 2014 |
Effects of exercise training on indicators of adipose tissue angiogenesis and hypoxia in obese rats.
Topics: Adipose Tissue; Animals; Biomarkers; Hypoxia; Lactic Acid; Male; Neovascularization, Pathologic; Obe | 2014 |
iNGR-modified PEG-PLGA nanoparticles that recognize tumor vasculature and penetrate gliomas.
Topics: Administration, Intravenous; Animals; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Collage | 2014 |
Endothelial PFKFB3 plays a critical role in angiogenesis.
Topics: Animals; Cell Proliferation; Cells, Cultured; Endothelial Cells; Female; Glycolysis; Humans; Lactic | 2014 |
Improved antitumor activity and reduced cardiotoxicity of epirubicin using hepatocyte-targeted nanoparticles combined with tocotrienols against hepatocellular carcinoma in mice.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; C | 2014 |
Efficient inhibition of intraperitoneal human ovarian cancer growth by short hairpin RNA targeting CD44.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Female; Humans; Hyaluronan Receptors; Lact | 2014 |
A mutation in the mitochondrial protein UQCRB promotes angiogenesis through the generation of mitochondrial reactive oxygen species.
Topics: Adenosine Triphosphate; Base Sequence; Bridged Bicyclo Compounds; Carrier Proteins; Cell Proliferati | 2014 |
PLGA/poloxamer nanoparticles loaded with EPAS1 siRNA for the treatment of pancreatic cancer in vitro and in vivo.
Topics: Animals; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cell Proliferati | 2015 |
Sunitinib microspheres based on [PDLLA-PEG-PDLLA]-b-PLLA multi-block copolymers for ocular drug delivery.
Topics: Administration, Ophthalmic; Angiogenesis Inhibitors; Animals; Chick Embryo; Chorioallantoic Membrane | 2015 |
A lactate-induced response to hypoxia.
Topics: Cell Hypoxia; Cell Line; Gene Expression Regulation; Humans; Hypoxia; Hypoxia-Inducible Factor-Proli | 2015 |
Development of thalidomide-loaded biodegradable devices and evaluation of the effect on inhibition of inflammation and angiogenesis after subcutaneous application.
Topics: Acetylglucosaminidase; Animals; Biocompatible Materials; Calorimetry, Differential Scanning; Disease | 2015 |
GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar for improved in vivo anticolorectal cancer treatment.
Topics: Angiogenesis Inhibitors; Animals; Benzenesulfonates; Cell Line, Tumor; Colorectal Neoplasms; Endosta | 2015 |
Monitoring Tumor Targeting and Treatment Effects of IRDye 800CW and GX1-Conjugated Polylactic Acid Nanoparticles Encapsulating Endostar on Glioma by Optical Molecular Imaging.
Topics: Animals; Benzenesulfonates; Body Weight; Cell Line, Tumor; Drug Delivery Systems; Endostatins; Fluor | 2015 |
Multiple tissue response modifiers to promote angiogenesis and prevent the foreign body reaction around subcutaneous implants.
Topics: Angiogenesis Inhibitors; Animals; Chemistry, Pharmaceutical; Dexamethasone; Drug Implants; Foreign-B | 2015 |
PLGA-encapsulated tea polyphenols enhance the chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma.
Topics: Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Biflavonoids; Carcinoma, Ehrlich Tumor; Cat | 2015 |
Controlled release of a heterogeneous human placental matrix from PLGA microparticles to modulate angiogenesis.
Topics: Biocompatible Materials; Cell Culture Techniques; Cell-Derived Microparticles; Cells, Cultured; Fema | 2016 |
Voxel-by-voxel correlations of perfusion, substrate, and metabolite signals in dynamic hyperpolarized (13) C imaging.
Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Cell Line, | 2016 |
G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion.
Topics: Amphiregulin; Animals; Apoptosis; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Ce | 2016 |
Cancer treatment scheduling and dynamic heterogeneity in social dilemmas of tumour acidity and vasculature.
Topics: Cell Proliferation; Disease Progression; Energy Metabolism; Game Theory; Glycolysis; Humans; Hydroge | 2017 |
Metabolic origins of spatial organization in the tumor microenvironment.
Topics: Cell Line, Tumor; Cluster Analysis; Energy Metabolism; Extracellular Space; Gene Expression Profilin | 2017 |
Effect of physical exercise on tumor growth regulating factors of tumor microenvironment: implications in exercise-dependent tumor growth retardation.
Topics: Animals; Ascitic Fluid; Cytokines; Hydrogen-Ion Concentration; Lactic Acid; Lymphoma; Male; Mice; Mi | 2009 |
Potential use of biodegradable nanoparticles for the photodynamic therapy of eye diseases.
Topics: Animals; Biotransformation; Chick Embryo; Chorioallantoic Membrane; Choroidal Neovascularization; Co | 2009 |
Consequences of seeded cell type on vascularization of tissue engineering constructs in vivo.
Topics: Alkaline Phosphatase; Animals; Biocompatible Materials; Bone Marrow Cells; Carbocyanines; Cells, Cul | 2009 |
Perfusion MR imaging and 1H spectroscopy: their role in the diagnosis of microcystic and lipomatous meningiomas.
Topics: Adipocytes; Aged; Blood Volume; Cerebral Angiography; Cerebral Cortex; Energy Metabolism; Female; Hu | 2010 |
Tetraidothyroacetic acid (tetrac) and tetrac nanoparticles inhibit growth of human renal cell carcinoma xenografts.
Topics: Animals; Carcinoma, Renal Cell; Cell Growth Processes; Cell Line, Tumor; Chick Embryo; Chorioallanto | 2009 |
Intravital microscopy evaluation of angiogenesis and its effects on glucose sensor performance.
Topics: Animals; Biosensing Techniques; Blood Glucose; Erythrocytes; Glucose; Lactic Acid; Male; Microscopy; | 2010 |
Peptide-conjugated biodegradable nanoparticles as a carrier to target paclitaxel to tumor neovasculature.
Topics: Aldehydes; Animals; Antineoplastic Agents, Phytogenic; Biocompatible Materials; Cell Movement; Cells | 2010 |
Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential.
Topics: Anti-Inflammatory Agents; Apoptosis; Benzoquinones; Cell Line, Tumor; Cell Proliferation; Drug Carri | 2010 |
Tetraiodothyroacetic acid (tetrac) and nanoparticulate tetrac arrest growth of medullary carcinoma of the thyroid.
Topics: Animals; Antineoplastic Agents; Body Weight; Carcinoma, Medullary; Cells, Cultured; Chick Embryo; Ch | 2010 |
Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice.
Topics: Animals; Delayed-Action Preparations; Disease Models, Animal; Extracellular Signal-Regulated MAP Kin | 2010 |
Injectable sustained release microparticles of curcumin: a new concept for cancer chemoprevention.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor | 2010 |
The pigment epithelial-derived factor gene loaded in PLGA nanoparticles for therapy of colon carcinoma.
Topics: Animals; Apoptosis; Carcinoma; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Dependovirus | 2010 |
Temozolomide/PLGA microparticles plus vatalanib inhibits tumor growth and angiogenesis in an orthotopic glioma model.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc | 2010 |
Hyperpolarized 13C spectroscopic imaging informs on hypoxia-inducible factor-1 and myc activity downstream of platelet-derived growth factor receptor.
Topics: Animals; Benzamides; Capillary Permeability; Carbon Isotopes; Humans; Hypoxia-Inducible Factor 1; Im | 2010 |
Chemotherapy with PLGA microspheres containing docetaxel decreases angiogenesis in human hepatoma xenograft.
Topics: Angiopoietin-2; Animals; Antineoplastic Agents; Delayed-Action Preparations; Docetaxel; Drug Carrier | 2012 |
Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis.
Topics: Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Colorectal Neoplasms; Humans; Hypoxia-Ind | 2011 |
Rabbit rubeosis iridis induced by intravitreal latex-derived angiogenic fraction.
Topics: Angiogenesis Inducing Agents; Animals; Disease Models, Animal; Disease Progression; Drug Carriers; F | 2011 |
Antitumor effects of PLGA nanoparticles encapsulating the human PNAS-4 gene combined with cisplatin in ovarian cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Body Weight; Carbon-Nitrog | 2011 |
Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.
Topics: Animals; Autophagy; Breast Neoplasms; Caveolin 1; Cell Communication; Cell Growth Processes; Cell Li | 2011 |
Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.
Topics: Analysis of Variance; Animals; Blotting, Western; Cell Movement; Endothelial Cells; Enzyme-Linked Im | 2012 |
Anti-VEGFR2-conjugated PLGA microspheres as an x-ray phase contrast agent for assessing the VEGFR2 expression.
Topics: Animals; Antibodies; Biomarkers; Cell Line, Tumor; Contrast Media; Gene Expression Regulation; Human | 2012 |
Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production.
Topics: Animals; Autocrine Communication; Autophagy; Breast Neoplasms; Caveolin 1; Cell Line, Tumor; Cell Tr | 2012 |
Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth.
Topics: Adenosine Triphosphate; Autophagy; Cell Line, Tumor; Cell Transformation, Neoplastic; Energy Metabol | 2012 |
Metabolic remodeling of the tumor microenvironment: migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth.
Topics: Actins; Animals; Autophagy; Biomarkers, Tumor; cdc42 GTP-Binding Protein; Cell Cycle Checkpoints; Ce | 2012 |
CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis.
Topics: Animals; Autophagy; Breast Neoplasms; Cell Cycle; Cell Proliferation; Cellular Senescence; Cyclin-De | 2012 |
Controlled release of imatinib mesylate from PLGA microspheres inhibit craniopharyngioma mediated angiogenesis.
Topics: Antineoplastic Agents; Benzamides; Chromatography, High Pressure Liquid; Craniopharyngioma; Imatinib | 2013 |
Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells.
Topics: Animals; Basigin; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Glycolysis; Humans; Hypoxia-I | 2012 |
Effect of lactate and bicarbonate on human peritoneal mesothelial cells, fibroblasts and vascular endothelial cells, and the role of basic fibroblast growth factor.
Topics: Bicarbonates; Cells, Cultured; Culture Media, Conditioned; Dialysis Solutions; Endothelium, Vascular | 2004 |
Incorporation of polymer microspheres within fibrin scaffolds for the controlled delivery of FGF-1.
Topics: Animals; Biocompatible Materials; Drug Carriers; Drug Delivery Systems; Fibrin; Fibroblast Growth Fa | 2004 |
Effects of inhibition of the polyol pathway during chronic peritoneal exposure to a dialysis solution.
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Dialysis Solutions; Enzyme Inhibitors; Fibrosis; Glucos | 2005 |
Angiogenic and inflammatory response to biodegradable scaffolds in dorsal skinfold chambers of mice.
Topics: Absorbable Implants; Animals; Biocompatible Materials; Dermatitis; Female; Hydrogels; Lactic Acid; M | 2006 |
[Study of the anti-tumor effect of anti-vascular endothelial growth factor McAb 5-fluorouracil loaded polylactic acid nanoparticles].
Topics: Animals; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Cell Line, Tumor; Drug Carriers; F | 2007 |
Sustained delivery of IL-1 Ra from biodegradable microspheres reduces the number of murine B16 melanoma lung metastases.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmaceutical; Del | 2007 |
Cyclosporin A induces peritoneal fibrosis and angiogenesis during chronic peritoneal exposure to a glucose-based, lactate-buffered dialysis solution in the rat.
Topics: Animals; Cyclosporine; Fibrosis; Glucose; Hemodialysis Solutions; Lactic Acid; Male; Neovascularizat | 2007 |
A new image analysis method for the quantification of neovascularization.
Topics: Allantois; Animals; Autoanalysis; Benzoquinones; Chick Embryo; Chorion; Colchicine; Extraembryonic M | 1984 |
Biochemical modulation of angiogenesis in the chorioallantoic membrane of the chick embryo.
Topics: Acetylcholine; Adenosine Diphosphate; Allantois; Animals; Autacoids; Blood Vessels; Chick Embryo; Ch | 1983 |
Studies on inflammation and wound healing: angiogenesis and collagen synthesis stimulated in vivo by resident and activated wound macrophages.
Topics: Animals; Cell Movement; Collagen; Cornea; Corneal Injuries; Corneal Opacity; Keratitis; Lactates; La | 1984 |
The role of increased lactic acid concentration in neovascularizations.
Topics: Animals; Cell Division; Cell Movement; Corneal Diseases; Edema; Eye; Humans; Lactates; Lactic Acid; | 1984 |
Antitumor effect of arterial administration of a medium-chain triglyceride solution of an angiogenesis inhibitor, TNP-470, in rabbits bearing VX-2 carcinoma.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Caprylates; Ca | 1995 |
Aqueous humour lactic acid and proteins in eyes with iris neovascularization.
Topics: Adult; Aged; Aged, 80 and over; Aqueous Humor; Cataract; Eye Proteins; Humans; Iris; Lactates; Lacti | 1994 |
Controlled delivery of taxol from microspheres composed of a blend of ethylene-vinyl acetate copolymer and poly (d,l-lactic acid).
Topics: Animals; Chick Embryo; Delayed-Action Preparations; In Vitro Techniques; Lactates; Lactic Acid; Micr | 1995 |
Incorporation of polylactide-polyglycolide in a cortical defect: neoosteogenesis in a bone chamber.
Topics: Absorption; Animals; Biocompatible Materials; Bone Regeneration; Female; Image Processing, Computer- | 1993 |
Sustained angiogenesis enables in vivo transplantation of mucocutaneous derived AIDS-related Kaposi's sarcoma cells in murine hosts.
Topics: Acquired Immunodeficiency Syndrome; Animals; Cattle; Delayed-Action Preparations; Disease Models, An | 2000 |
Axonal regeneration into Schwann cell grafts within resorbable poly(alpha-hydroxyacid) guidance channels in the adult rat spinal cord.
Topics: Animals; Axons; Biocompatible Materials; Female; Lactic Acid; Materials Testing; Myelin Sheath; Neov | 2001 |
Angiopolarity of cell carriers: directional angiogenesis in resorbable liver cell transplantation devices.
Topics: Animals; Biocompatible Materials; Lactic Acid; Liver Circulation; Liver Transplantation; Microsphere | 1992 |
Lactic acid neovascularisation.
Topics: Animals; Cats; Lactates; Lactic Acid; Neovascularization, Pathologic; Rats; Retinal Vessels | 1991 |
Metabolic factors from exercising muscle and the proliferation of endothelial cells.
Topics: Adenosine; Animals; Cell Division; Cells, Cultured; Dogs; Endothelium; Female; Hindlimb; Hydrogen-Io | 1986 |