lactic acid has been researched along with Amyotrophic Lateral Sclerosis in 19 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the efficacy of curcumin oral supplementation (600 mg/day, Brainoil), a natural antioxidant compound, in Amyotrophic Lateral Sclerosis (ALS)." | 9.27 | Amyotrophic Lateral Sclerosis and Oxidative Stress: A Double-Blind Therapeutic Trial After Curcumin Supplementation. ( Bisordi, C; Chico, L; Ienco, EC; Lo Gerfo, A; Mancuso, M; Petrozzi, L; Petrucci, A; Siciliano, G, 2018) |
| "In this study, we aim to verify whether swim training can improve lactate metabolism, NAD+ and NADH levels, as well as modify the activity of glycolytic and NADH shuttle enzymes and monocarboxylate transporters (MCTs) in skeletal muscle of amyotrophic lateral sclerosis (ALS) mice." | 8.12 | Swim Training Affects on Muscle Lactate Metabolism, Nicotinamide Adenine Dinucleotides Concentration, and the Activity of NADH Shuttle Enzymes in a Mouse Model of Amyotrophic Lateral Sclerosis. ( Antosiewicz, J; Cieminski, K; Dzik, KP; Flis, DJ; Kaczor, JJ; Wieckowski, MR; Ziolkowski, W, 2022) |
| "To investigate the efficacy of curcumin oral supplementation (600 mg/day, Brainoil), a natural antioxidant compound, in Amyotrophic Lateral Sclerosis (ALS)." | 5.27 | Amyotrophic Lateral Sclerosis and Oxidative Stress: A Double-Blind Therapeutic Trial After Curcumin Supplementation. ( Bisordi, C; Chico, L; Ienco, EC; Lo Gerfo, A; Mancuso, M; Petrozzi, L; Petrucci, A; Siciliano, G, 2018) |
| "In this study, we aim to verify whether swim training can improve lactate metabolism, NAD+ and NADH levels, as well as modify the activity of glycolytic and NADH shuttle enzymes and monocarboxylate transporters (MCTs) in skeletal muscle of amyotrophic lateral sclerosis (ALS) mice." | 4.12 | Swim Training Affects on Muscle Lactate Metabolism, Nicotinamide Adenine Dinucleotides Concentration, and the Activity of NADH Shuttle Enzymes in a Mouse Model of Amyotrophic Lateral Sclerosis. ( Antosiewicz, J; Cieminski, K; Dzik, KP; Flis, DJ; Kaczor, JJ; Wieckowski, MR; Ziolkowski, W, 2022) |
| "Amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease) is a progressive debilitating neurodegenerative disease with no cure." | 2.48 | Lactate dyscrasia: a novel explanation for amyotrophic lateral sclerosis. ( Atwood, CS; Vadakkadath Meethal, S, 2012) |
| "To assess how often mitochondrial myopathy (MMP) mimics amyotrophic lateral sclerosis (ALS) and the phenotypic similarities and differences between these two disorders." | 1.31 | Mitochondriopathy as a differential diagnosis of amyotrophic lateral sclerosis. ( Finsterer, J, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.53) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 11 (57.89) | 24.3611 |
| 2020's | 3 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Bøgh, N | 1 |
| Laustsen, C | 1 |
| Hansen, ESS | 1 |
| Tankisi, H | 1 |
| Bertelsen, LB | 1 |
| Blicher, JU | 1 |
| Cieminski, K | 1 |
| Flis, DJ | 1 |
| Dzik, KP | 1 |
| Kaczor, JJ | 1 |
| Wieckowski, MR | 1 |
| Antosiewicz, J | 1 |
| Ziolkowski, W | 1 |
| Vandoorne, T | 1 |
| Veys, K | 1 |
| Guo, W | 1 |
| Sicart, A | 1 |
| Vints, K | 1 |
| Swijsen, A | 1 |
| Moisse, M | 1 |
| Eelen, G | 1 |
| Gounko, NV | 1 |
| Fumagalli, L | 1 |
| Fazal, R | 1 |
| Germeys, C | 1 |
| Quaegebeur, A | 1 |
| Fendt, SM | 1 |
| Carmeliet, P | 1 |
| Verfaillie, C | 1 |
| Van Damme, P | 1 |
| Ghesquière, B | 1 |
| De Bock, K | 1 |
| Van Den Bosch, L | 1 |
| Gyawali, A | 1 |
| Kang, YS | 1 |
| Lanfranconi, F | 1 |
| Ferri, A | 1 |
| Corna, G | 1 |
| Bonazzi, R | 1 |
| Lunetta, C | 1 |
| Silani, V | 1 |
| Riva, N | 1 |
| Rigamonti, A | 1 |
| Maggiani, A | 1 |
| Ferrarese, C | 1 |
| Tremolizzo, L | 1 |
| Yang, LP | 1 |
| Fan, DS | 2 |
| Chico, L | 1 |
| Ienco, EC | 1 |
| Bisordi, C | 1 |
| Lo Gerfo, A | 1 |
| Petrozzi, L | 1 |
| Petrucci, A | 1 |
| Mancuso, M | 1 |
| Siciliano, G | 3 |
| Gray, E | 1 |
| Larkin, JR | 1 |
| Claridge, TD | 1 |
| Talbot, K | 1 |
| Sibson, NR | 1 |
| Turner, MR | 1 |
| Zhang, YJ | 1 |
| Ferraiuolo, L | 2 |
| Meyer, K | 1 |
| Sherwood, TW | 1 |
| Vick, J | 1 |
| Likhite, S | 1 |
| Frakes, A | 1 |
| Miranda, CJ | 1 |
| Braun, L | 1 |
| Heath, PR | 2 |
| Pineda, R | 1 |
| Beattie, CE | 1 |
| Shaw, PJ | 2 |
| Askwith, CC | 1 |
| McTigue, D | 1 |
| Kaspar, BK | 1 |
| Pradat, PF | 1 |
| Bruneteau, G | 1 |
| Gordon, PH | 1 |
| Dupuis, L | 1 |
| Bonnefont-Rousselot, D | 1 |
| Simon, D | 1 |
| Salachas, F | 1 |
| Corcia, P | 1 |
| Frochot, V | 1 |
| Lacorte, JM | 1 |
| Jardel, C | 1 |
| Coussieu, C | 1 |
| Le Forestier, N | 1 |
| Lacomblez, L | 1 |
| Loeffler, JP | 1 |
| Meininger, V | 1 |
| Vadakkadath Meethal, S | 1 |
| Atwood, CS | 1 |
| Higginbottom, A | 1 |
| Barber, S | 1 |
| Greenald, D | 1 |
| Kirby, J | 1 |
| Lee, Y | 1 |
| Morrison, BM | 1 |
| Li, Y | 1 |
| Lengacher, S | 1 |
| Farah, MH | 1 |
| Hoffman, PN | 1 |
| Liu, Y | 1 |
| Tsingalia, A | 1 |
| Jin, L | 1 |
| Zhang, PW | 1 |
| Pellerin, L | 1 |
| Magistretti, PJ | 1 |
| Rothstein, JD | 1 |
| D'Avino, C | 1 |
| Del Corona, A | 1 |
| Barsacchi, R | 1 |
| Kusmic, C | 1 |
| Rocchi, A | 1 |
| Pastorini, E | 2 |
| Murri, L | 2 |
| Finsterer, J | 1 |
| Pasquali, L | 1 |
| Manca, ML | 1 |
| Iudice, A | 1 |
| Yase, Y | 1 |
| Sanjak, M | 1 |
| Paulson, D | 1 |
| Sufit, R | 1 |
| Reddan, W | 1 |
| Beaulieu, D | 1 |
| Erickson, L | 1 |
| Shug, A | 1 |
| Brooks, BR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of Moderate Aerobic Exercise as Determined by Cardiopulmonary Exercise Testing in ALS[NCT03326622] | 48 participants (Actual) | Interventional | 2013-07-01 | Completed | |||
| Impact of the Combined Treatment of Curcumin and Resveratrol Liposomed Polyphenols With G04CB02 on the Clinical Improvement of ALS Patients[NCT04654689] | Phase 2 | 90 participants (Actual) | Interventional | 2021-11-20 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for lactic acid and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Lactate dyscrasia: a novel explanation for amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Humans; Lactic Acid; Mitochondrial Diseases; Nerve Degenerat | 2012 |
3 trials available for lactic acid and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Amyotrophic Lateral Sclerosis and Oxidative Stress: A Double-Blind Therapeutic Trial After Curcumin Supplementation.
Topics: Advanced Oxidation Protein Products; Aged; Amyotrophic Lateral Sclerosis; Anti-Inflammatory Agents, | 2018 |
Impaired oxidative metabolism and lipid peroxidation in exercising muscle from ALS patients.
Topics: Aged; Amyotrophic Lateral Sclerosis; Biopsy; Exercise Test; Female; Humans; Lactic Acid; Lipid Perox | 2002 |
Impaired oxidative metabolism in exercising muscle from ALS patients.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Electromyography; Exercise Test; Female; Heart Rate; Hum | 2001 |
15 other studies available for lactic acid and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Imaging Neurodegenerative Metabolism in Amyotrophic Lateral Sclerosis with Hyperpolarized [1-
Topics: Amyotrophic Lateral Sclerosis; Bicarbonates; Humans; Lactic Acid; Magnetic Resonance Imaging; Neurod | 2022 |
Swim Training Affects on Muscle Lactate Metabolism, Nicotinamide Adenine Dinucleotides Concentration, and the Activity of NADH Shuttle Enzymes in a Mouse Model of Amyotrophic Lateral Sclerosis.
Topics: Adenine; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Lactic Acid; Malate Dehydro | 2022 |
Differentiation but not ALS mutations in FUS rewires motor neuron metabolism.
Topics: Amyotrophic Lateral Sclerosis; Case-Control Studies; Cell Differentiation; Cell Respiration; Glucose | 2019 |
Transport Alteration of 4-Phenyl Butyric Acid Mediated by a Sodium- and Proton-Coupled Monocarboxylic Acid Transporter System in ALS Model Cell Lines (NSC-34) Under Inflammatory States.
Topics: Amyotrophic Lateral Sclerosis; Butyrates; Cell Line; Humans; Hydrogen Peroxide; Lactic Acid; Monocar | 2021 |
Inefficient skeletal muscle oxidative function flanks impaired motor neuron recruitment in Amyotrophic Lateral Sclerosis during exercise.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Exercise; Exercise Test; Female; Humans; Lactic Acid; Ma | 2017 |
Diets for Patients with Amyotrophic Lateral Sclerosis: Pay Attention to Nutritional Intervention.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antioxidants; Diet, Ketogenic; Female; Humans; Lactic Acid; | 2017 |
The longitudinal cerebrospinal fluid metabolomic profile of amyotrophic lateral sclerosis.
Topics: Aged; Amyotrophic Lateral Sclerosis; Biomarkers; Case-Control Studies; Citric Acid; Cohort Studies; | 2015 |
Elimination Rate of Serum Lactate is Correlated with Amyotrophic Lateral Sclerosis Progression.
Topics: Adult; Amyotrophic Lateral Sclerosis; Analysis of Variance; Disease Progression; Female; Humans; Kap | 2016 |
Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism.
Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Biomarkers; C9orf72 Protein; Cell Communication; | 2016 |
Impaired glucose tolerance in patients with amyotrophic lateral sclerosis.
Topics: Adiponectin; Adolescent; Adult; Aged; Amyotrophic Lateral Sclerosis; Blood Glucose; Fatty Acids, Non | 2010 |
Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Cell Communication; Cell Death; Cells, Cultured; | 2011 |
Oligodendroglia metabolically support axons and contribute to neurodegeneration.
Topics: Amyotrophic Lateral Sclerosis; Animals; Axons; Cell Line; Cell Survival; Disease Models, Animal; Dow | 2012 |
Mitochondriopathy as a differential diagnosis of amyotrophic lateral sclerosis.
Topics: Action Potentials; Adult; Aged; Amyotrophic Lateral Sclerosis; Diagnosis, Differential; Electromyogr | 2002 |
The pathogenetic role of metals in motor neuron disease--the participation of aluminum.
Topics: Amyotrophic Lateral Sclerosis; Animals; Anterior Horn Cells; Calcium; Central Nervous System; Guam; | 1987 |
Physiologic and metabolic response to progressive and prolonged exercise in amyotrophic lateral sclerosis.
Topics: 3-Hydroxybutyric Acid; Amyotrophic Lateral Sclerosis; Carnitine; Exercise Test; Fatty Acids, Noneste | 1987 |