lactic acid has been researched along with Alzheimer Disease in 72 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Both cancer and Alzheimer's disease (AD) are emerging as metabolic diseases in which aberrant/dysregulated glucose metabolism and bioenergetics occur, and play a key role in disease progression." | 2.61 | Synthesis and metabolism of methylglyoxal, S-D-lactoylglutathione and D-lactate in cancer and Alzheimer's disease. Exploring the crossroad of eternal youth and premature aging. ( Armeni, T; Atlante, A; de Bari, L; Kalapos, MP, 2019) |
| "Curcumin is a natural product with several anti-Alzheimer's disease (AD) neuroprotective properties." | 1.51 | Curcumin Ameliorates Memory Deficits by Enhancing Lactate Content and MCT2 Expression in APP/PS1 Transgenic Mouse Model of Alzheimer's Disease. ( Gan, SW; Huang, J; Huang, SQ; Jiang, XL; Li, Y; Lu, WT; Qiu, GP; Sun, SQ; Xu, J; Xu, SY; Zhuo, F, 2019) |
| "Conditions include Alzheimer's disease, atherosclerosis, diabetes mellitus, obesity, cancer, autoimmunity and psychosis, amongst others." | 1.48 | Optimise the microbial flora with milk and yoghurt to prevent disease. ( Morris, JA, 2018) |
| "As nattokinase is a protein, its stability restricts its usage to a greater extent, but this limitation can be overcome by nanoencapsulation." | 1.46 | Development of surface-engineered PLGA nanoparticulate-delivery system of Tet1-conjugated nattokinase enzyme for inhibition of Aβ ( Al-Abbasi, FA; Anwar, F; Bhatt, PC; Kumar, V; Panda, BP; Verma, A, 2017) |
| "To investigate, in patients with Alzheimer's Disease (AD), the possible interplay linking alteration of neuronal energy metabolism, as measured via cerebrospinal fluid (CSF) lactate concentration, to severity of AD neurodegenerative processes and impairment of cognitive abilities." | 1.42 | CSF lactate levels, τ proteins, cognitive decline: a dynamic relationship in Alzheimer's disease. ( Liguori, C; Marciani, MG; Pierantozzi, M; Sancesario, G; Sancesario, GM; Stefani, A, 2015) |
| "Curcumin is a plant derived compound which has potential activities beneficial for the treatment of Alzheimer's disease." | 1.38 | Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's disease. ( Fukuda, T; Hasumura, T; Kumar, DS; Maekawa, T; Mathew, A; Morimoto, H; Nagaoka, Y; Venugopal, K; Yoshida, Y, 2012) |
| "The progression of Alzheimer's disease (AD) is accompanied by disturbances of the endosome/lysosome (EL) system and there is accumulation of peptides of the AD-associated amyloid beta (Abeta) type in EL vesicles of affected neurons." | 1.38 | Beneficial effects of lysosome-modulating and other pharmacological and nanocarrier agents on amyloid-beta-treated cells. ( Chen, L; Fuchs, PM; Kanazirska, MV; Lal, S; Vassilev, PM; Verma, J, 2012) |
| "Alzheimer's disease is characterized by beta-amyloid plaques, tau pathology, cell death of cholinergic neurons, inflammatory processes and cerebrovascular damage." | 1.35 | [Does acidosis in brain play a role in Alzheimer's disease?]. ( Humpel, C; Pirchl, M, 2009) |
| "The canine counterpart of senile dementia of the Alzheimer type (ccSDAT) is considered a promising model for examining behavioral, cellular and molecular processes involved in early phases of human brain aging and Alzheimer disease (AD)." | 1.33 | Severe cognitive impairment correlates with higher cerebrospinal fluid levels of lactate and pyruvate in a canine model of senile dementia. ( Andrade, C; Carrasco, JL; Mahy, N; Mas, E; Mascort, J; Pugliese, M, 2005) |
| "Alzheimer's disease is a progressive brain disorder which is neuropathologically characterized by an increased number of beta-amyloid plaques, tau pathology and synapse loss." | 1.33 | Effects of acidosis on brain capillary endothelial cells and cholinergic neurons: relevance to vascular dementia and Alzheimer's disease. ( Humpel, C; Marksteiner, J; Pirchl, M, 2006) |
| "Many enzyme activities in Alzheimer's disease (AD) are changed." | 1.30 | Affected enzyme activities in Alzheimer's disease are sensitive to antemortem hypoxia. ( Bothmer, J; Jolles, J; Meng, F; Terwel, D; Wolf, E, 1998) |
| "Alzheimer's disease is associated with selective neuronal loss, the cause of which is undetermined." | 1.27 | Altered metabolic properties of cultured skin fibroblasts in Alzheimer's disease. ( Blass, JP; Finegan, JM; Sims, NR, 1987) |
| "The group with presenile dementia showed no uptake of amino acids, but a significant release of phenylalanine; in addition, CMR of alanine and threonine was significantly lower than in the healthy subjects." | 1.26 | Cerebral blood flow and metabolic rate of oxygen, glucose, lactate, pyruvate, ketone bodies and amino acids. ( Lindblad, BS; Lying-Tunell, U; Malmlund, HO; Persson, B, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (6.94) | 18.7374 |
| 1990's | 11 (15.28) | 18.2507 |
| 2000's | 13 (18.06) | 29.6817 |
| 2010's | 35 (48.61) | 24.3611 |
| 2020's | 8 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, Q | 1 |
| Jeppesen, DK | 1 |
| Higginbotham, JN | 1 |
| Graves-Deal, R | 1 |
| Trinh, VQ | 1 |
| Ramirez, MA | 1 |
| Sohn, Y | 1 |
| Neininger, AC | 1 |
| Taneja, N | 1 |
| McKinley, ET | 1 |
| Niitsu, H | 1 |
| Cao, Z | 1 |
| Evans, R | 1 |
| Glass, SE | 1 |
| Ray, KC | 1 |
| Fissell, WH | 1 |
| Hill, S | 1 |
| Rose, KL | 1 |
| Huh, WJ | 1 |
| Washington, MK | 1 |
| Ayers, GD | 1 |
| Burnette, DT | 1 |
| Sharma, S | 1 |
| Rome, LH | 1 |
| Franklin, JL | 1 |
| Lee, YA | 1 |
| Liu, Q | 1 |
| Coffey, RJ | 1 |
| Samir, M | 1 |
| Abdelkader, RM | 1 |
| Boushehri, MS | 1 |
| Mansour, S | 1 |
| Lamprecht, A | 1 |
| Tammam, SN | 1 |
| Shirbandi, K | 1 |
| Rikhtegar, R | 1 |
| Khalafi, M | 1 |
| Mirza Aghazadeh Attari, M | 1 |
| Rahmani, F | 1 |
| Javanmardi, P | 1 |
| Iraji, S | 1 |
| Babaei Aghdam, Z | 1 |
| Rezaei Rashnoudi, AM | 1 |
| Wei, L | 1 |
| Yang, X | 1 |
| Wang, J | 2 |
| Wang, Z | 1 |
| Wang, Q | 1 |
| Ding, Y | 1 |
| Yu, A | 1 |
| Tian, Q | 1 |
| Li, J | 1 |
| Wu, B | 1 |
| Xiao, Q | 1 |
| Tian, N | 1 |
| Yi, L | 1 |
| Luo, M | 1 |
| Li, Z | 2 |
| Pang, Y | 1 |
| Shi, X | 1 |
| Dong, Z | 1 |
| Dharshini, SAP | 1 |
| Taguchi, YH | 1 |
| Gromiha, MM | 1 |
| Jin, N | 1 |
| Ziyatdinova, S | 1 |
| Gureviciene, I | 1 |
| Tanila, H | 1 |
| Yoo, ID | 1 |
| Park, MW | 1 |
| Cha, HW | 1 |
| Yoon, S | 1 |
| Boonpraman, N | 1 |
| Yi, SS | 1 |
| Moon, JS | 1 |
| Powell, CL | 1 |
| Davidson, AR | 1 |
| Brown, AM | 1 |
| Liguori, C | 3 |
| Mercuri, NB | 2 |
| Izzi, F | 1 |
| Romigi, A | 1 |
| Cordella, A | 1 |
| Sancesario, G | 3 |
| Placidi, F | 1 |
| Oksanen, M | 1 |
| Petersen, AJ | 1 |
| Naumenko, N | 1 |
| Puttonen, K | 1 |
| Lehtonen, Š | 1 |
| Gubert Olivé, M | 1 |
| Shakirzyanova, A | 1 |
| Leskelä, S | 1 |
| Sarajärvi, T | 1 |
| Viitanen, M | 1 |
| Rinne, JO | 1 |
| Hiltunen, M | 1 |
| Haapasalo, A | 1 |
| Giniatullin, R | 1 |
| Tavi, P | 1 |
| Zhang, SC | 1 |
| Kanninen, KM | 1 |
| Hämäläinen, RH | 1 |
| Koistinaho, J | 1 |
| Bhatt, PC | 1 |
| Verma, A | 1 |
| Al-Abbasi, FA | 1 |
| Anwar, F | 1 |
| Kumar, V | 1 |
| Panda, BP | 1 |
| Meng, Q | 1 |
| Wang, A | 1 |
| Hua, H | 1 |
| Jiang, Y | 1 |
| Wang, Y | 1 |
| Mu, H | 1 |
| Wu, Z | 1 |
| Sun, K | 1 |
| Morris, JA | 1 |
| Lu, WT | 1 |
| Sun, SQ | 1 |
| Li, Y | 1 |
| Xu, SY | 1 |
| Gan, SW | 1 |
| Xu, J | 2 |
| Qiu, GP | 1 |
| Zhuo, F | 1 |
| Huang, SQ | 1 |
| Jiang, XL | 1 |
| Huang, J | 2 |
| Zhang, M | 1 |
| Cheng, X | 1 |
| Dang, R | 1 |
| Zhang, W | 3 |
| Zhang, J | 1 |
| Yao, Z | 2 |
| de Bari, L | 1 |
| Atlante, A | 1 |
| Armeni, T | 1 |
| Kalapos, MP | 1 |
| Tang, X | 1 |
| Bomba, M | 1 |
| Ciavardelli, D | 1 |
| Silvestri, E | 1 |
| Canzoniero, LM | 1 |
| Lattanzio, R | 1 |
| Chiappini, P | 1 |
| Piantelli, M | 1 |
| Di Ilio, C | 1 |
| Consoli, A | 1 |
| Sensi, SL | 1 |
| Herrán, E | 2 |
| Pérez-González, R | 2 |
| Igartua, M | 3 |
| Pedraz, JL | 3 |
| Carro, E | 2 |
| Hernández, RM | 3 |
| Paban, V | 1 |
| Manrique, C | 1 |
| Filali, M | 1 |
| Maunoir-Regimbal, S | 1 |
| Fauvelle, F | 1 |
| Alescio-Lautier, B | 1 |
| Correia, SC | 1 |
| Perry, G | 1 |
| Castellani, R | 1 |
| Moreira, PI | 1 |
| Ding, F | 1 |
| Yao, J | 1 |
| Rettberg, JR | 1 |
| Chen, S | 1 |
| Brinton, RD | 1 |
| Stefani, A | 2 |
| Sancesario, GM | 2 |
| Marciani, MG | 1 |
| Pierantozzi, M | 2 |
| Lu, W | 2 |
| Sun, S | 1 |
| Huang, S | 1 |
| Gan, S | 1 |
| Yang, M | 1 |
| Xu, S | 1 |
| Jiang, X | 2 |
| Sriramoju, B | 1 |
| Kanwar, RK | 1 |
| Kanwar, JR | 1 |
| Clark, IA | 1 |
| Vissel, B | 1 |
| Doolaanea, AA | 1 |
| Mansor, N' | 1 |
| Mohd Nor, NH | 1 |
| Mohamed, F | 1 |
| Loureiro, JA | 1 |
| Gomes, B | 1 |
| Fricker, G | 1 |
| Coelho, MAN | 1 |
| Rocha, S | 1 |
| Pereira, MC | 1 |
| Muntimadugu, E | 1 |
| Dhommati, R | 1 |
| Jain, A | 1 |
| Challa, VG | 1 |
| Shaheen, M | 1 |
| Khan, W | 1 |
| Chiaravalloti, A | 1 |
| Schillaci, O | 1 |
| Martire, S | 1 |
| Fuso, A | 1 |
| Mosca, L | 1 |
| Forte, E | 1 |
| Correani, V | 1 |
| Fontana, M | 1 |
| Scarpa, S | 1 |
| Maras, B | 1 |
| d'Erme, M | 1 |
| Sun, D | 1 |
| Li, N | 1 |
| Zhao, Z | 1 |
| Mou, Z | 1 |
| Huang, D | 1 |
| Liu, J | 1 |
| Wang, W | 1 |
| Gibbs, ME | 1 |
| Gibbs, Z | 1 |
| Hertz, L | 1 |
| Pirchl, M | 2 |
| Humpel, C | 2 |
| Ball, KK | 1 |
| Cruz, NF | 1 |
| Mrak, RE | 1 |
| Dienel, GA | 1 |
| Barcia, E | 1 |
| Salama, A | 1 |
| Fernández-Carballido, A | 1 |
| Negro, S | 1 |
| Mittal, G | 1 |
| Carswell, H | 1 |
| Brett, R | 1 |
| Currie, S | 1 |
| Kumar, MN | 1 |
| Bero, AW | 1 |
| Yan, P | 1 |
| Roh, JH | 1 |
| Cirrito, JR | 1 |
| Stewart, FR | 1 |
| Raichle, ME | 1 |
| Lee, JM | 1 |
| Holtzman, DM | 1 |
| Puras, G | 1 |
| Salvador, A | 1 |
| Yu, Y | 1 |
| Pang, Z | 1 |
| Yin, Q | 1 |
| Gao, H | 1 |
| Mathew, A | 1 |
| Fukuda, T | 1 |
| Nagaoka, Y | 1 |
| Hasumura, T | 1 |
| Morimoto, H | 1 |
| Yoshida, Y | 1 |
| Maekawa, T | 1 |
| Venugopal, K | 1 |
| Kumar, DS | 1 |
| Doggui, S | 1 |
| Dao, L | 1 |
| Ramassamy, C | 1 |
| Kanazirska, MV | 1 |
| Fuchs, PM | 1 |
| Chen, L | 1 |
| Lal, S | 1 |
| Verma, J | 1 |
| Vassilev, PM | 1 |
| Mancuso, M | 1 |
| Filosto, M | 1 |
| Bosetti, F | 1 |
| Ceravolo, R | 1 |
| Rocchi, A | 1 |
| Tognoni, G | 1 |
| Manca, ML | 1 |
| Solaini, G | 1 |
| Siciliano, G | 1 |
| Murri, L | 1 |
| Aubert-Pouëssel, A | 1 |
| Venier-Julienne, MC | 1 |
| Clavreul, A | 1 |
| Sergent, M | 1 |
| Jollivet, C | 1 |
| Montero-Menei, CN | 1 |
| Garcion, E | 1 |
| Bibby, DC | 1 |
| Menei, P | 1 |
| Benoit, JP | 1 |
| LaRue, B | 1 |
| Hogg, E | 1 |
| Sagare, A | 1 |
| Jovanovic, S | 1 |
| Maness, L | 1 |
| Maurer, C | 1 |
| Deane, R | 1 |
| Zlokovic, BV | 1 |
| Dahm, R | 1 |
| Kálmán, J | 1 |
| Palotás, A | 1 |
| Bódi, N | 1 |
| Kincses, TZ | 1 |
| Benedek, G | 1 |
| Janka, Z | 1 |
| Antal, A | 1 |
| Pugliese, M | 1 |
| Carrasco, JL | 1 |
| Andrade, C | 1 |
| Mas, E | 1 |
| Mascort, J | 1 |
| Mahy, N | 1 |
| Liu, WH | 1 |
| Song, JL | 1 |
| Liu, K | 1 |
| Chu, DF | 1 |
| Li, YX | 1 |
| Petrovitch, H | 1 |
| White, L | 1 |
| Fu, X | 1 |
| Ping, Q | 1 |
| Gao, Y | 1 |
| Marksteiner, J | 1 |
| Gao, P | 1 |
| Xu, H | 1 |
| Ding, P | 1 |
| Gao, Q | 1 |
| Sun, J | 1 |
| Chen, D | 1 |
| Lying-Tunell, U | 1 |
| Lindblad, BS | 1 |
| Malmlund, HO | 1 |
| Persson, B | 1 |
| Block, W | 1 |
| Träber, F | 1 |
| Kuhl, CK | 1 |
| Fric, M | 1 |
| Keller, E | 1 |
| Lamerichs, R | 1 |
| Rink, H | 1 |
| Möller, HJ | 1 |
| Schild, HH | 1 |
| Sorbi, S | 1 |
| Piacentini, S | 1 |
| Latorraca, S | 1 |
| Piersanti, P | 1 |
| Amaducci, L | 1 |
| Hoyer, S | 2 |
| Parnetti, L | 1 |
| Gaiti, A | 1 |
| Brunetti, M | 1 |
| Avellini, L | 1 |
| Polidori, C | 1 |
| Cecchetti, R | 1 |
| Palumbo, B | 1 |
| Senin, U | 1 |
| Domingo, JL | 1 |
| Gomez, M | 1 |
| Sanchez, DJ | 1 |
| Llobet, JM | 1 |
| Corbella, J | 1 |
| Redjems-Bennani, N | 1 |
| Jeandel, C | 1 |
| Lefebvre, E | 1 |
| Blain, H | 1 |
| Vidailhet, M | 1 |
| Guéant, JL | 1 |
| Terwel, D | 1 |
| Bothmer, J | 1 |
| Wolf, E | 1 |
| Meng, F | 1 |
| Jolles, J | 1 |
| Malm, J | 1 |
| Kristensen, B | 1 |
| Ekstedt, J | 1 |
| Adolfsson, R | 1 |
| Wester, P | 1 |
| Panchalingam, K | 1 |
| Sachedina, S | 1 |
| Pettegrew, JW | 1 |
| Glonek, T | 1 |
| Yates, CM | 1 |
| Butterworth, J | 1 |
| Tennant, MC | 1 |
| Gordon, A | 1 |
| Morandi, A | 1 |
| Los, B | 1 |
| Osofsky, L | 1 |
| Autilio-Gambetti, L | 1 |
| Gambetti, P | 1 |
| Lukiw, WJ | 1 |
| Kruck, TP | 1 |
| McLachlan, DR | 1 |
| Awerbuch, G | 1 |
| Peterson, P | 1 |
| Sandyk, R | 1 |
| Sims, NR | 1 |
| Finegan, JM | 1 |
| Blass, JP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| SIESTA: Sleep Intervention to Enhance Cognitive Status and Reduce Beta Amyloid[NCT03954210] | 200 participants (Anticipated) | Interventional | 2019-08-27 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for lactic acid and Alzheimer Disease
| Article | Year |
|---|---|
Functional Magnetic Resonance Spectroscopy of Lactate in Alzheimer Disease: A Comprehensive Review of Alzheimer Disease Pathology and the Role of Lactate.
Topics: Alzheimer Disease; Humans; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy | 2023 |
Universal Glia to Neurone Lactate Transfer in the Nervous System: Physiological Functions and Pathological Consequences.
Topics: Alzheimer Disease; Animals; Astrocytes; Brain; Glucose; Glycogen; Humans; Lactic Acid; Nervous Syste | 2020 |
Synthesis and metabolism of methylglyoxal, S-D-lactoylglutathione and D-lactate in cancer and Alzheimer's disease. Exploring the crossroad of eternal youth and premature aging.
Topics: Aging, Premature; Alzheimer Disease; Animals; Energy Metabolism; Glutathione; Glycolysis; Humans; La | 2019 |
Nitric oxide might be an inducing factor in cognitive impairment in Alzheimer's disease via downregulating the monocarboxylate transporter 1.
Topics: Alzheimer Disease; Animals; Cognitive Dysfunction; Down-Regulation; Humans; Lactic Acid; Monocarboxy | 2019 |
Amyloid β: one of three danger-associated molecules that are secondary inducers of the proinflammatory cytokines that mediate Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cytokines; Humans; Inflammation Mediators; Lactic | 2015 |
Ubiquitin and heat shock proteins in cultured nervous tissue after different stress conditions.
Topics: Alzheimer Disease; Cells, Cultured; Ganglia, Spinal; Heat-Shock Proteins; Hot Temperature; Humans; L | 1989 |
3 trials available for lactic acid and Alzheimer Disease
| Article | Year |
|---|---|
Decreased platelet cytochrome c oxidase activity is accompanied by increased blood lactate concentration during exercise in patients with Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Blood Platelets; Electron Transport Complex IV; Energy M | 2003 |
Lactate infusion fails to improve semantic categorization in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Double-Blind Method; Electroenceph | 2005 |
Possible role of ammonia in the brain in dementia of Alzheimer type.
Topics: Adenosine Triphosphate; Adult; Aged; Alzheimer Disease; Amino Acids; Ammonia; Brain Chemistry; Cereb | 1994 |
63 other studies available for lactic acid and Alzheimer Disease
| Article | Year |
|---|---|
Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets.
Topics: Alzheimer Disease; Angiotensin-Converting Enzyme 2; Biological Transport; Biomarkers; Cardiovascular | 2021 |
Enhancement of mitochondrial function using NO releasing nanoparticles; a potential approach for therapy of Alzheimer's disease.
Topics: Adenosine Triphosphate; Alzheimer Disease; Animals; Lactic Acid; Mice; Mitochondria; Nanoparticles; | 2023 |
H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer's disease through the NFκB signaling pathway.
Topics: Aging; Alzheimer Disease; Animals; Brain; Histones; Interleukin-6; Interleukin-8; Lactic Acid; Mice; | 2023 |
Hypoxia-sensing VGLL4 promotes LDHA-driven lactate production to ameliorate neuronal dysfunction in a cellular model relevant to Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Hypoxia; Lactic A | 2023 |
Investigating the energy crisis in Alzheimer disease using transcriptome study.
Topics: Acetylation; Aged; Aged, 80 and over; Alzheimer Disease; Computational Biology; Computer Simulation; | 2019 |
Response of spike-wave discharges in aged APP/PS1 Alzheimer model mice to antiepileptic, metabolic and cholinergic drugs.
Topics: 3-Hydroxybutyric Acid; Action Potentials; Alzheimer Disease; Animals; Anticonvulsants; Atropine; Dis | 2020 |
Elevated CLOCK and BMAL1 Contribute to the Impairment of Aerobic Glycolysis from Astrocytes in Alzheimer's Disease.
Topics: Aerobiosis; Alzheimer Disease; ARNTL Transcription Factors; Astrocytes; Cells, Cultured; CLOCK Prote | 2020 |
Obstructive Sleep Apnea is Associated With Early but Possibly Modifiable Alzheimer's Disease Biomarkers Changes.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Cognition; Cognitive Dysfunction; Contin | 2017 |
PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Brain; Calcium; Gene Expression Regul | 2017 |
Development of surface-engineered PLGA nanoparticulate-delivery system of Tet1-conjugated nattokinase enzyme for inhibition of Aβ
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antifibrinolytic Agents; Calorimetry, Differential Scannin | 2017 |
Intranasal delivery of Huperzine A to the brain using lactoferrin-conjugated N-trimethylated chitosan surface-modified PLGA nanoparticles for treatment of Alzheimer's disease.
Topics: Administration, Intranasal; Alkaloids; Alzheimer Disease; Animals; Brain; Chitosan; Drug Carriers; D | 2018 |
Optimise the microbial flora with milk and yoghurt to prevent disease.
Topics: Alzheimer Disease; Animals; Autoimmunity; Bacteria; Bifidobacterium; Cattle; Diabetes Mellitus; Ferm | 2018 |
Curcumin Ameliorates Memory Deficits by Enhancing Lactate Content and MCT2 Expression in APP/PS1 Transgenic Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents, Non-Steroidal; | 2019 |
Lactate Deficit in an Alzheimer Disease Mouse Model: The Relationship With Neuronal Damage.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Lactic Acid; Mice; | 2018 |
Exenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognition Disorders; Diabetes Mellitus, Ex | 2013 |
VEGF-releasing biodegradable nanospheres administered by craniotomy: a novel therapeutic approach in the APP/Ps1 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloidogenic Proteins; Animals; Behavior, Animal; Cell Survival; Cells, Cultured | 2013 |
Therapeutic and preventive effects of methylene blue on Alzheimer's disease pathology in a transgenic mouse model.
Topics: Administration, Oral; Alanine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Avoidance Learning | 2014 |
Is exercise-in-a-bottle likely to proffer new insights into Alzheimer's disease?
Topics: Alzheimer Disease; Animals; Brain; Exercise; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lact | 2013 |
Early decline in glucose transport and metabolism precedes shift to ketogenic system in female aging and Alzheimer's mouse brain: implication for bioenergetic intervention.
Topics: Adaptation, Physiological; Aging; Alzheimer Disease; Animals; Astrocytes; Biological Transport, Acti | 2013 |
CSF lactate levels, τ proteins, cognitive decline: a dynamic relationship in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Cognition Disorders; | 2015 |
Changes in lactate content and monocarboxylate transporter 2 expression in Aβ₂₅₋₃₅-treated rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Cognition Disorders; Disease Mod | 2015 |
Nanoformulated Mutant SurR9-C84A: a Possible Key for Alzheimer's and its Associated Inflammation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anti-Inflammatory Agents; Apoptosis; Cell Line; Chemistry, | 2015 |
Enhanced Hippocampal Neurogenesis in APP/Ps1 Mouse Model of Alzheimer's Disease After Implantation of VEGF-loaded PLGA Nanospheres.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Biodegradable Plastics; Cell Proliferati | 2015 |
Co-encapsulation of Nigella sativa oil and plasmid DNA for enhanced gene therapy of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cell Line; DNA; Drug Carriers; Genetic Therapy; Humans; Lactic Acid; Mic | 2016 |
Cellular uptake of PLGA nanoparticles targeted with anti-amyloid and anti-transferrin receptor antibodies for Alzheimer's disease treatment.
Topics: Alzheimer Disease; Amyloid; Animals; Antibodies; Blood-Brain Barrier; Brain; Lactic Acid; Nanopartic | 2016 |
Intranasal delivery of nanoparticle encapsulated tarenflurbil: A potential brain targeting strategy for Alzheimer's disease.
Topics: Administration, Intranasal; Alzheimer Disease; Animals; Brain; Drug Carriers; Drug Delivery Systems; | 2016 |
Cerebrospinal fluid lactate levels and brain [18F]FDG PET hypometabolism within the default mode network in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Brain; Brain Diseases, Metabolic; Fluorodeoxyglucose F18; Glucose; Humans; | 2016 |
Bioenergetic Impairment in Animal and Cellular Models of Alzheimer's Disease: PARP-1 Inhibition Rescues Metabolic Dysfunctions.
Topics: Adenosine Triphosphate; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; An | 2016 |
Design of PLGA-functionalized quercetin nanoparticles for potential use in Alzheimer's disease.
Topics: Alzheimer Disease; Circular Dichroism; Humans; Lactic Acid; Microscopy, Electron, Transmission; Nano | 2016 |
Rescue of Abeta(1-42)-induced memory impairment in day-old chick by facilitation of astrocytic oxidative metabolism: implications for Alzheimer's disease.
Topics: 3-Hydroxybutyric Acid; Acetates; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn | 2009 |
[Does acidosis in brain play a role in Alzheimer's disease?].
Topics: Acidosis; Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Brain; Brain Ischemia; Cell | 2009 |
Trafficking of glucose, lactate, and amyloid-beta from the inferior colliculus through perivascular routes.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain Chemistry; Chromatography, High Pressure Li | 2010 |
Protective effects of clioquinol on human neuronal-like cells: a new formulation of clioquinol-loaded PLGA microspheres for Alzheimer's disease.
Topics: Alzheimer Disease; Biocompatible Materials; Cell Culture Techniques; Cell Death; Cell Line, Tumor; C | 2011 |
Development and evaluation of polymer nanoparticles for oral delivery of estradiol to rat brain in a model of Alzheimer's pathology.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anxiety; Astrocytes; Behavi | 2011 |
Neuronal activity regulates the regional vulnerability to amyloid-β deposition.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cerebral Cortex; | 2011 |
Encapsulation of Aβ(1-15) in PLGA microparticles enhances serum antibody response in mice immunized by subcutaneous and intranasal routes.
Topics: Administration, Intranasal; Alzheimer Disease; Alzheimer Vaccines; Amyloid beta-Peptides; Animals; D | 2011 |
Self-assembled polymersomes conjugated with lactoferrin as novel drug carrier for brain delivery.
Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Caspase 3; Coumarins; Cryoelectron Microscopy; Drug | 2012 |
Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Animals; Antioxidants; Biological Transport; Cell Line, Tumor; Curcumin; | 2012 |
Potential of drug-loaded nanoparticles for Alzheimer's disease: diagnosis, prevention and treatment.
Topics: Alzheimer Disease; Humans; Lactic Acid; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycol | 2012 |
Beneficial effects of lysosome-modulating and other pharmacological and nanocarrier agents on amyloid-beta-treated cells.
Topics: Acetylcarnitine; Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Tumor; Cell Survival; Drug Car | 2012 |
In vitro study of GDNF release from biodegradable PLGA microspheres.
Topics: Alzheimer Disease; Animals; Biodegradation, Environmental; Chemistry, Pharmaceutical; Delayed-Action | 2004 |
Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice.
Topics: Adenosine Triphosphate; Alzheimer Disease; Amyloid beta-Peptides; Animals; Autoradiography; Blood-Br | 2004 |
Dying to see.
Topics: Acquired Immunodeficiency Syndrome; Aged; Aging; Alzheimer Disease; Animals; Apoptosis; Cataract; Ey | 2004 |
Severe cognitive impairment correlates with higher cerebrospinal fluid levels of lactate and pyruvate in a canine model of senile dementia.
Topics: Aging; Alzheimer Disease; Animals; Behavior, Animal; Biomarkers; Brain Chemistry; Cerebrospinal Flui | 2005 |
Preparation and in vitro and in vivo release studies of Huperzine A loaded microspheres for the treatment of Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Desiccation; Dogs; Drug Compoundin | 2005 |
Exercise and cognitive function.
Topics: Aged; Alzheimer Disease; Cognition; Cognition Disorders; Exercise; Humans; Lactic Acid; Middle Aged; | 2005 |
Effects of formulation factors on encapsulation efficiency and release behaviour in vitro of huperzine A-PLGA microspheres.
Topics: Alkaloids; Alzheimer Disease; Delayed-Action Preparations; Drug Compounding; Humans; Lactic Acid; Mi | 2005 |
Effects of acidosis on brain capillary endothelial cells and cholinergic neurons: relevance to vascular dementia and Alzheimer's disease.
Topics: Acetylcholine; Acidosis; Acids; Alzheimer Disease; Animals; Astrocytes; Cell Death; Dementia, Vascul | 2006 |
Controlled release of huperzine A from biodegradable microspheres: In vitro and in vivo studies.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Calorimetry, Differential Scanning; Cer | 2007 |
Cerebral blood flow and metabolic rate of oxygen, glucose, lactate, pyruvate, ketone bodies and amino acids.
Topics: Aged; Alzheimer Disease; Amino Acids; Brain; Cerebrospinal Fluid Shunts; Cerebrovascular Circulation | 1981 |
[1H-MR spectroscopic imaging in patients with clinically diagnosed Alzheimer's disease].
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Creatine; Hippocampus; Humans; Lactates; Lac | 1995 |
Alterations in metabolic properties in fibroblasts in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Blood Glucose; Chromosome Aberrations; Chromosome Disorders; Energy Metabol | 1995 |
Increased CSF pyruvate levels as a marker of impaired energy metabolism in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Biomarkers; Case-Control Studies; Energy Metabolism; Female; Humans; Lactat | 1995 |
Effect of various dietary constituents on gastrointestinal absorption of aluminum from drinking water and diet.
Topics: Aluminum; Alzheimer Disease; Animals; Bone and Bones; Brain; Carboxylic Acids; Chelating Agents; Cit | 1993 |
Abnormal substrate levels that depend upon mitochondrial function in cerebrospinal fluid from Alzheimer patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cerebrospinal Fluid; Citric Acid Cycle; Female; Fumarate | 1998 |
Affected enzyme activities in Alzheimer's disease are sensitive to antemortem hypoxia.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Brain; Cadaver; Female; Humans; Hypoxia; L | 1998 |
CSF monoamine metabolites, cholinesterases and lactate in the adult hydrocephalus syndrome (normal pressure hydrocephalus) related to CSF hydrodynamic parameters.
Topics: Aged; Alzheimer Disease; Cerebrospinal Fluid Pressure; Cholinesterases; Dementia, Multi-Infarct; Fem | 1991 |
Al-ATP as an intracellular carrier of Al(III) ion.
Topics: Adenosine Triphosphate; Aluminum; Alzheimer Disease; Biological Transport, Active; Cytoplasm; Erythr | 1991 |
Abnormalities of glucose metabolism in Alzheimer's disease.
Topics: Adult; Aged; Alzheimer Disease; Brain; Carbon Dioxide; Cerebrovascular Circulation; Glucose; Humans; | 1991 |
Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias.
Topics: Alzheimer Disease; Dementia; Humans; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Neurons; Pos | 1990 |
Linker histone-DNA complexes: enhanced stability in the presence of aluminum lactate and implications for Alzheimer's disease.
Topics: Alzheimer Disease; DNA; DNA-Binding Proteins; Histones; Humans; In Vitro Techniques; Lactates; Lacti | 1989 |
Elevated cerebrospinal fluid lactic acid levels in Creutzfeldt-Jakob disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Creutzfeldt-Jakob Syndrome; Dementia, Multi-Infarct; Fem | 1988 |
Altered metabolic properties of cultured skin fibroblasts in Alzheimer's disease.
Topics: Alzheimer Disease; Blood Glucose; Carbon Dioxide; Cells, Cultured; Energy Metabolism; Fibroblasts; H | 1987 |