lactic acid has been researched along with Alloxan Diabetes in 248 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the inhibitory effects of 25-hydroxyvitamin D3 (25(OH)D3)-loaded polylactic acid (PLA) microspheres on inflammatory response in diabetic periodontitis." | 7.80 | Attenuation of inflammatory response by 25- hydroxyvitamin D3-loaded polylactic acid microspheres in treatment of periodontitis in diabetic rats. ( Chen, XM; Li, B; Li, H; Li, W; Wang, Q; Xiao, Y, 2014) |
| " However, low peroral bioavailability is a major limiting factor for the success of clinical utilization of curcumin." | 5.39 | Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model. ( Balakrishna, N; Grama, CN; Kumar, MN; Patil, MA; Raghu, G; Reddy, GB; Suryanarayana, P, 2013) |
| "To investigate the inhibitory effects of 25-hydroxyvitamin D3 (25(OH)D3)-loaded polylactic acid (PLA) microspheres on inflammatory response in diabetic periodontitis." | 3.80 | Attenuation of inflammatory response by 25- hydroxyvitamin D3-loaded polylactic acid microspheres in treatment of periodontitis in diabetic rats. ( Chen, XM; Li, B; Li, H; Li, W; Wang, Q; Xiao, Y, 2014) |
| " It was found that the development of diabetes mellitus is associated with dramatic changes in the metabolism of blood cells and kidney tissue: inhibition of aerobic ATP synthesis, accumulation of lactate, uncoupling of oxidative phosphorylation, and development of lactic acidosis." | 3.79 | Dysfunction of membrane-receptor system of blood cells and kidney tissue in experimental diabetes mellitus. ( Gurina, AE; Mikaelian, NP; Terent'ev, AA, 2013) |
| " In this study we evaluated the effect of global brain ischemia on brain metabolic parameters in normal and diabetic rats treated with a dihydropyridine calcium antagonist, felodipine." | 3.72 | The effect of global brain ischemia in normal and diabetic animals: the influence of calcium channel blockers. ( Dunbar, JC; Levy, J; Zhu, Z, 2004) |
| " We assessed the effect of a novel oral antilipolytic agent, N-[(1S, trans)-2-hydroxycyclopentyl]adenosine (GR 79236), in experimental diabetic ketoacidosis." | 3.69 | Improvement of ketoacidosis in the diabetic rat after the administration of the oral antilipolytic agent GR 79236. ( Mikhailidis, DP; Strong, P; Thompson, CS, 1994) |
| ""In vitro" isometric developed tension (IDT) and frequency of contractions (FC), glucose (Glu), glycogen (GLY) and triglyceride (TG) metabolism, as well as prostaglandin PGE2 and PGE1 production, were studied in uterine strips and in embryos isolated from controls and diabetic rats at day 10 of pregnancy." | 3.68 | Glucose, glycogen and triglyceride metabolism, as well as prostaglandin production in uterine strips and in embryos from diabetic pregnant rats. Influences of the presence of substrate in the incubation medium. ( Catafau, JR; Gimeno, AL; Gimeno, MA; Gomez, G; Gonzalez, ET; Jawerbaum, A; Rodriguez, RR, 1993) |
| " The pharmacological availability (PA%) and bioavailability (FR%) for insulin-loaded ChAuNps/PLGA were 15." | 1.72 | Controlled synthesis of in-situ gold nanoparticles onto chitosan functionalized PLGA nanoparticles for oral insulin delivery. ( Asal, HA; El-Hagrasy, MA; Shoueir, KR; Toson, EA, 2022) |
| "Treatment with metformin improved these parameters." | 1.62 | Metformin mitigates impaired testicular lactate transport/utilisation and improves sexual behaviour in streptozotocin-induced diabetic rats. ( Abu Bakar, AB; Ahmad, A; Mohamed, M; Nna, VU, 2021) |
| " However, this system presents a bioavailability of less than 20% for insulin encapsulation." | 1.48 | Oral insulin delivery, the challenge to increase insulin bioavailability: Influence of surface charge in nanoparticle system. ( Auberval, N; Bietiger, W; Czuba, E; Diop, M; Frere, Y; Julien-David, D; Langlois, A; Maillard, E; Marchioni, E; Mura, C; Neidl, R; Pinget, M; Schaschkow, A; Sigrist, S; Virciglio, A, 2018) |
| "Cerebral ischemia is a serious possible manifestation of diabetic vascular disease." | 1.48 | Acidosis mediates recurrent hypoglycemia-induced increase in ischemic brain injury in treated diabetic rats. ( Dave, KR; Perez-Pinzon, MA; Rehni, AK; Shukla, V, 2018) |
| "To improve insulin bioavailability and overcome multiple barriers for oral delivery of insulin, the composite nanocarriers (PLGA/FA-CS) prepared from poly(lactide-co-glycoside) (PLGA) and folic acid modified chitosan (FA-CS) were fabricated via electrostatic self-assembly method." | 1.46 | Preparation of poly(lactic-co-glycolic acid) and chitosan composite nanocarriers via electrostatic self assembly for oral delivery of insulin. ( Jiang, G; Kong, X; Liu, D; Liu, Y; Xu, B; Yao, J; Yu, W, 2017) |
| " It is obvious that patient compliance can be improved greatly if insulin could be formulated in an oral dosage form." | 1.43 | Dextran-b-poly(lactide-co-glycolide) polymersome for oral delivery of insulin: In vitro and in vivo evaluation. ( Abnous, K; Alabdollah, F; Alibolandi, M; Hadizadeh, F; Mohammadi, M; Ramezani, M; Sadeghi, F, 2016) |
| " These results suggest that the developed platform has great potential to enhance the efficacy for implants in cases where the cell dosage is critical for efficacy, such as islet transplantation and ischemic tissues." | 1.43 | Improvement of islet engrafts by enhanced angiogenesis and microparticle-mediated oxygenation. ( Ashtiani, MK; Baharvand, H; Bonakdar, S; Hajizadeh-Saffar, E; Hojjati-Emami, S; Montazeri, L; Najar-Asl, M; Noori-Keshtkar, M; Tahamtani, Y, 2016) |
| " In addition, GCMs had a longer interval between dosing (two weeks) and a lower dosage(2." | 1.43 | Effects of Pluronic F127-PEG multi-gel-core on the release profile and pharmacodynamics of Exenatide loaded in PLGA microspheres. ( Cai, C; Gong, H; Gou, J; Ren, T; Tang, X; Wang, P; Wang, Q; Zhang, Y, 2016) |
| " Once the MS were optimised, the target loading of rhEGF was increased to 1% (PLGA-Alginate MS), and particles were sterilised by gamma radiation to provide the correct dosage for in vivo studies." | 1.39 | rhEGF-loaded PLGA-Alginate microspheres enhance the healing of full-thickness excisional wounds in diabetised Wistar rats. ( Aguirre, JJ; Gainza, G; Hernández, RM; Igartua, M; Pedraz, JL, 2013) |
| " However, low peroral bioavailability is a major limiting factor for the success of clinical utilization of curcumin." | 1.39 | Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model. ( Balakrishna, N; Grama, CN; Kumar, MN; Patil, MA; Raghu, G; Reddy, GB; Suryanarayana, P, 2013) |
| " Nanoparticle insulin results in six fold increase in oral bioavailability to that of plain insulin in healthy rats." | 1.39 | Antacid co-encapsulated polyester nanoparticles for peroral delivery of insulin: development, pharmacokinetics, biodistribution and pharmacodynamics. ( Ravi Kumar, MN; Sharma, G; van der Walle, CF, 2013) |
| "FA-PEG-PLGA NPs (50 U/kg) exhibited a twofold increase in the oral bioavailability (double hypoglycemia) without any hypoglycemic shock as compared to subcutaneously administered standard insulin solution." | 1.38 | Folate-decorated PLGA nanoparticles as a rationally designed vehicle for the oral delivery of insulin. ( Das, M; Godugu, C; Jain, AK; Jain, S; Rathi, VV, 2012) |
| "Titanium implants were planted into the tibias of the diabetic rats and into 10 normal rats." | 1.38 | Effects of local delivery of bFGF from PLGA microspheres on osseointegration around implants in diabetic rats. ( Deng, ZX; Li, DH; Liang, LH; Song, YL; Sun, DC; Yu, M; Zhou, W; Zhu, WZ; Zou, GK, 2012) |
| "Despite treatment, this syndrome complicated the interpretation of blood glucose readings as a measure of islet graft function and resulted in death or the need for euthanasia in all seven animals." | 1.38 | A syndrome of severe hypoglycemia and acidosis in young immunosuppressed diabetic monkeys and pigs-association with sepsis. ( Bottino, R; Cooper, DK; Dons, EM; Echeverri, GJ; Rigatti, LH; van der Windt, DJ; Wagner, R; Wijkstrom, M; Zhou, H, 2012) |
| " Pharmacokinetic analysis demonstrated that insulin administered in PLGA microcapsules illustrated a sustained release profile which resulted in a longer mean residence time, 4 and 5 fold longer than those after pulmonary administration of RSDI and SC injection of NPH insulin, respectively." | 1.36 | Pharmacokinetics and pharmacodynamics of controlled release insulin loaded PLGA microcapsules using dry powder inhaler in diabetic rats. ( Emami, J; Gilani, K; Hamishehkar, H; Hassanzadeh, K; Koohsoltani, M; Mahdavi, H; Minaiyan, M; Najafabadi, AR; Nokhodchi, A, 2010) |
| " Surface-modified NPs could be used to improve patient compliance with drug treatment as a result of decreased dosing frequency." | 1.35 | Repaglinide-loaded long-circulating biodegradable nanoparticles: rational approach for the management of type 2 diabetes mellitus. ( Jain, S; Saraf, S, 2009) |
| " The pharmacological effect of PLGA/HPbetaCD/insulin LPP was confirmed by dose-response studies performed on both normoglycaemic and streptozotocin-induced diabetic rats." | 1.35 | Insulin-loaded PLGA/cyclodextrin large porous particles with improved aerosolization properties: in vivo deposition and hypoglycaemic activity after delivery to rat lungs. ( d'Emmanuele di Villa Bianca, R; Giovino, C; La Rotonda, MI; Miro, A; Quaglia, F; Sorrentino, R; Ungaro, F, 2009) |
| " The relative bioavailability of PNP and PHNP compared with subcutaneous (s." | 1.34 | Preparation of insulin loaded PLGA-Hp55 nanoparticles for oral delivery. ( Cui, FD; Cun, DM; Shi, K; Tao, AJ; Zhang, LQ, 2007) |
| "7% of oral bioavailability relative to subcutaneous injection was obtained." | 1.33 | Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: preparation, in vitro characterization and in vivo evaluation. ( Cui, F; Kawashima, Y; Shi, K; Tao, A; Zhang, L, 2006) |
| " Multiple dosing given every 10 days demonstrated that the pharmacological effect and serum insulin levels from second or third doses were similar and comparable to that of the first dose." | 1.32 | Preparation and in vitro/in vivo evaluation of insulin-loaded poly(acryloyl-hydroxyethyl starch)-PLGA composite microspheres. ( DeLuca, PP; Jiang, G; Qiu, W, 2003) |
| "Stress hyperglycemia is frequent in critically ill patients." | 1.32 | Metabolic, endocrine, and immune effects of stress hyperglycemia in a rabbit model of prolonged critical illness. ( Coopmans, W; Giulietti, AP; Mathieu, C; Michalaki, M; Van den Berghe, G; Van Herck, E; Weekers, F, 2003) |
| "01) and the relative pharmacological bioavailability is (10." | 1.31 | [Study on preparation and oral efficacy of insulin-loaded poly(lactic-co-glycolic acid) nanoparticles]. ( Pan, Y; Wei, G; Xu, H; Zhao, HY; Zheng, JM, 2002) |
| " The release profile of the microcapsules was designed to mimic a dosing regimen of multiple injections of TAK-778 solution." | 1.31 | Enhancement of fracture repair in rats with streptozotocin-induced diabetes by a single injection of biodegradable microcapsules containing a bone formation stimulant, TAK-778. ( Hoshino, T; Makino, H; Muranishi, H; Nagai, H; Notoya, K; Ogawa, Y; Saito, K; Sohda, T, 2000) |
| "Lactic acidosis has been implicated; however, increases in the excitotoxic amino acid glutamate, which correlate with increased neuronal damage, may be the cause for the increased damage seen in hyperglycemic stroke." | 1.31 | The effect of streptozotocin-induced diabetes on the release of excitotoxic and other amino acids from the ischemic rat cerebral cortex. ( Diaz, FG; Guyot, LL; O'Regan, MH; Phillis, JW; Song, D, 2001) |
| "In conclusion, 12 weeks of streptozotocin diabetes in swine caused a significant decrease in myocardial GLUT4 protein and a decrease in myocardial glucose uptake during ischemia." | 1.30 | Decreased myocardial glucose uptake during ischemia in diabetic swine. ( Hacker, TA; Hall, JL; Hernandez, LA; Stanley, WC; Whitesell, LF, 1997) |
| "Alloxan treatment reduced nitric oxide generation, whereas L-arginine and sodium nitroprusside, when given along with alloxan, enhanced nitric oxide production to control values." | 1.30 | Effect of L-arginine-nitric oxide system on chemical-induced diabetes mellitus. ( Das, UN; Mohan, IK, 1998) |
| "3." | 1.29 | Chronic gliclazide treatment affects basal and post-ischemic cardiac function in diabetic rats. ( Mimura, G; Murakami, K; Nagamine, F; Oshiro, K; Shimabukuro, M, 1994) |
| " In accordance with the polyol theory, the chronic administration of SDI 157 to diabetic rats accelerated the cataract development and depleted the lens of total and oxidized glutathione." | 1.29 | Sorbitol-accumulating pyrimidine derivatives. ( Geisen, K; Grötsch, H; Lang, HJ; Nimmesgern, H; Utz, R, 1994) |
| "Glycerol was the best substrate for D-lactate formation via methylglyoxal in rat liver." | 1.29 | Carbon sources for D-lactate formation in rat liver. ( Hirata, M; Kawase, M; Kondoh, Y; Ohmori, S, 1994) |
| " Insulin from the PIS device maintained normal blood glucose levels for 10 d in diabetic rats as an implantable dosage form." | 1.29 | Controlled release of insulin from plasma-irradiated sandwitch device using poly-DL-lactic acid. ( Kuzuya, M; Matsuno, Y; Watanabe, S; Yamakawa, I, 1993) |
| "Plasma glucose in NIDDM rats was elevated (P less than 0." | 1.28 | Effect of insulin on glucose utilization in epitrochlearis muscle of rats with streptozocin-induced NIDDM. ( Gavin, JR; Karl, IE; Levy, J, 1990) |
| " Furthermore, 2-deoxyglucose uptake in CS-045-treated adipocytes was increased and the insulin dose-response curve was shifted to the left." | 1.27 | Characterization of new oral antidiabetic agent CS-045. Studies in KK and ob/ob mice and Zucker fatty rats. ( Fujiwara, T; Horikoshi, H; Ushiyama, I; Yoshioka, S; Yoshioka, T, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (16.53) | 18.7374 |
| 1990's | 45 (18.15) | 18.2507 |
| 2000's | 65 (26.21) | 29.6817 |
| 2010's | 81 (32.66) | 24.3611 |
| 2020's | 16 (6.45) | 2.80 |
| Authors | Studies |
|---|---|
| Hao, Q | 1 |
| Huang, Z | 1 |
| Li, Q | 1 |
| Liu, D | 2 |
| Wang, P | 3 |
| Wang, K | 1 |
| Li, J | 2 |
| Cao, W | 2 |
| Deng, W | 1 |
| Wu, K | 1 |
| Su, R | 1 |
| Liu, Z | 1 |
| Vadgama, J | 1 |
| Wu, Y | 2 |
| Li, M | 1 |
| Wang, S | 1 |
| Liu, X | 2 |
| Sheng, Z | 1 |
| Li, B | 3 |
| Zhang, J | 1 |
| Zhang, Z | 4 |
| Asal, HA | 1 |
| Shoueir, KR | 1 |
| El-Hagrasy, MA | 1 |
| Toson, EA | 1 |
| Zhao, L | 3 |
| Jiang, H | 1 |
| Xie, J | 1 |
| Shen, D | 1 |
| Yi, Q | 1 |
| Yan, J | 1 |
| Li, C | 2 |
| Zheng, H | 3 |
| Gao, H | 3 |
| Pang, H | 1 |
| Huang, X | 1 |
| Xu, ZP | 1 |
| Chen, C | 1 |
| Han, FY | 1 |
| Li, X | 2 |
| Zhang, Y | 2 |
| Xu, L | 1 |
| Wang, A | 1 |
| Zou, Y | 1 |
| Li, T | 1 |
| Huang, L | 2 |
| Chen, W | 1 |
| Liu, S | 1 |
| Jiang, K | 1 |
| Zhang, X | 2 |
| Wang, D | 2 |
| Zhang, L | 4 |
| Chen, X | 1 |
| Jia, W | 2 |
| Zhao, A | 1 |
| Yan, X | 1 |
| Zhou, H | 2 |
| Zhu, L | 1 |
| Ma, X | 1 |
| Ju, Z | 1 |
| Wang, C | 1 |
| Loscalzo, J | 1 |
| Yang, Y | 1 |
| Zhao, Y | 1 |
| Choi, YS | 1 |
| Song, JE | 1 |
| Kim, E | 1 |
| Kim, CH | 1 |
| Lee, JE | 1 |
| Song, HT | 1 |
| Choubey, M | 1 |
| Ranjan, A | 1 |
| Bora, PS | 1 |
| Krishna, A | 1 |
| Nna, VU | 2 |
| Bakar, ABA | 1 |
| Ahmad, A | 2 |
| Umar, UZ | 1 |
| Suleiman, JB | 1 |
| Zakaria, Z | 1 |
| Othman, ZA | 1 |
| Mohamed, M | 2 |
| Wang, SY | 1 |
| Zhu, S | 1 |
| Wu, J | 2 |
| Zhang, M | 1 |
| Xu, Y | 1 |
| Xu, W | 1 |
| Cui, J | 1 |
| Yu, B | 1 |
| Liu, J | 2 |
| Zhu, Y | 2 |
| Han, XQ | 1 |
| Sun, XJ | 1 |
| Yang, R | 1 |
| Ma, WQ | 1 |
| Liu, NF | 1 |
| Mato Mofo, EP | 1 |
| Essop, MF | 1 |
| Owira, PMO | 1 |
| Jha, MK | 2 |
| Ament, XH | 1 |
| Yang, F | 1 |
| Liu, Y | 2 |
| Polydefkis, MJ | 1 |
| Pellerin, L | 1 |
| Morrison, BM | 1 |
| Bhusal, A | 1 |
| Rahman, MH | 2 |
| Lee, WH | 1 |
| Lee, IK | 2 |
| Suk, K | 2 |
| Ikeda, H | 1 |
| Yamamoto, S | 1 |
| Kamei, J | 1 |
| Nørlinger, TS | 1 |
| Nielsen, PM | 2 |
| Qi, H | 1 |
| Mikkelsen, E | 1 |
| Hansen, K | 1 |
| Schmidt, NH | 1 |
| Pedersen, M | 3 |
| Agger, P | 1 |
| Palm, F | 2 |
| Laustsen, C | 3 |
| Xu, B | 1 |
| Jiang, G | 2 |
| Yu, W | 1 |
| Kong, X | 1 |
| Yao, J | 1 |
| Joshi, D | 1 |
| Sarkar, D | 1 |
| Singh, SK | 1 |
| Wu, MC | 1 |
| Ye, WR | 1 |
| Zheng, YJ | 1 |
| Zhang, SS | 1 |
| Liu, L | 1 |
| Tan, J | 1 |
| Xie, Q | 1 |
| Sun, J | 1 |
| Pu, H | 1 |
| Zhang, H | 2 |
| Wang, W | 2 |
| Li, H | 5 |
| Peng, Y | 1 |
| Wu, JZ | 1 |
| Williams, GR | 2 |
| Li, HY | 1 |
| Wang, DX | 1 |
| Li, SD | 1 |
| Zhu, LM | 2 |
| Tan, N | 1 |
| Zhou, Y | 1 |
| Wei, H | 1 |
| Ren, S | 1 |
| Yu, F | 1 |
| Chen, H | 1 |
| Jia, C | 1 |
| Yang, G | 1 |
| Song, Y | 1 |
| Shi, Y | 2 |
| Xue, J | 1 |
| Jia, L | 1 |
| Du, Q | 1 |
| Niu, J | 1 |
| Zhang, D | 1 |
| Pham, TT | 1 |
| Nguyen, TT | 1 |
| Pathak, S | 1 |
| Regmi, S | 1 |
| Nguyen, HT | 1 |
| Tran, TH | 1 |
| Yong, CS | 1 |
| Kim, JO | 1 |
| Park, PH | 1 |
| Park, MH | 1 |
| Bae, YK | 1 |
| Choi, JU | 1 |
| Byun, Y | 1 |
| Ahn, CH | 1 |
| Yook, S | 1 |
| Jeong, JH | 1 |
| Han, H | 1 |
| Lee, JS | 1 |
| Kim, H | 1 |
| Shin, S | 1 |
| Lee, J | 1 |
| Kim, J | 1 |
| Hou, X | 1 |
| Cho, SW | 1 |
| Seo, J | 1 |
| Lee, T | 1 |
| Morze, CV | 1 |
| Allu, PKR | 1 |
| Chang, GY | 1 |
| Marco-Rius, I | 1 |
| Milshteyn, E | 1 |
| Wang, ZJ | 1 |
| Ohliger, MA | 1 |
| Gleason, CE | 1 |
| Kurhanewicz, J | 1 |
| Vigneron, DB | 1 |
| Pearce, D | 1 |
| Czuba, E | 1 |
| Diop, M | 1 |
| Mura, C | 1 |
| Schaschkow, A | 1 |
| Langlois, A | 1 |
| Bietiger, W | 1 |
| Neidl, R | 1 |
| Virciglio, A | 1 |
| Auberval, N | 1 |
| Julien-David, D | 1 |
| Maillard, E | 1 |
| Frere, Y | 2 |
| Marchioni, E | 2 |
| Pinget, M | 2 |
| Sigrist, S | 2 |
| Rehni, AK | 1 |
| Shukla, V | 1 |
| Perez-Pinzon, MA | 1 |
| Dave, KR | 1 |
| Hassanin, KMA | 1 |
| Mahmoud, MO | 1 |
| Hassan, HM | 1 |
| Abdel-Razik, AH | 1 |
| Aziz, LN | 1 |
| Rateb, ME | 1 |
| Frigero, M | 1 |
| Dos Santos, SA | 1 |
| Serra, AJ | 1 |
| Dos Santos Monteiro Machado, C | 1 |
| Portes, LA | 1 |
| Tucci, PJF | 1 |
| Silva, F | 1 |
| Leal-Junior, EC | 1 |
| de Carvalho, PTC | 1 |
| Dong, M | 1 |
| Ren, M | 1 |
| Xie, S | 1 |
| Gong, YC | 1 |
| Xiong, XY | 1 |
| Li, ZL | 1 |
| Luo, YY | 1 |
| Li, YP | 1 |
| Ruegsegger, GN | 1 |
| Manjunatha, S | 1 |
| Summer, P | 1 |
| Gopala, S | 1 |
| Zabeilski, P | 1 |
| Dasari, S | 1 |
| Vanderboom, PM | 1 |
| Lanza, IR | 1 |
| Klaus, KA | 1 |
| Nair, KS | 1 |
| Rastegari, A | 1 |
| Mottaghitalab, F | 1 |
| Dinarvand, R | 2 |
| Amini, M | 1 |
| Arefian, E | 1 |
| Gholami, M | 1 |
| Atyabi, F | 2 |
| Abu Bakar, AB | 1 |
| Lipsø, K | 1 |
| Østergaard, JA | 2 |
| Bertelsen, LB | 1 |
| Flyvbjerg, A | 2 |
| Ardenkjær-Larsen, JH | 1 |
| Bomba, M | 1 |
| Ciavardelli, D | 1 |
| Silvestri, E | 1 |
| Canzoniero, LM | 1 |
| Lattanzio, R | 1 |
| Chiappini, P | 1 |
| Piantelli, M | 1 |
| Di Ilio, C | 1 |
| Consoli, A | 1 |
| Sensi, SL | 1 |
| Wang, Q | 4 |
| Xiao, Y | 3 |
| Bao, C | 2 |
| Li, W | 2 |
| Mikaelian, NP | 1 |
| Gurina, AE | 1 |
| Terent'ev, AA | 1 |
| Dang, TT | 1 |
| Thai, AV | 1 |
| Cohen, J | 1 |
| Slosberg, JE | 1 |
| Siniakowicz, K | 1 |
| Doloff, JC | 1 |
| Ma, M | 1 |
| Hollister-Lock, J | 1 |
| Tang, KM | 1 |
| Gu, Z | 2 |
| Cheng, H | 1 |
| Weir, GC | 1 |
| Langer, R | 1 |
| Anderson, DG | 1 |
| Arantes, LM | 1 |
| Bertolini, NO | 1 |
| de Moura, RF | 1 |
| de Mello, MA | 3 |
| Luciano, E | 3 |
| Gainza, G | 1 |
| Aguirre, JJ | 1 |
| Pedraz, JL | 1 |
| Hernández, RM | 1 |
| Igartua, M | 1 |
| Chan, O | 1 |
| Paranjape, SA | 1 |
| Horblitt, A | 1 |
| Zhu, W | 1 |
| Sherwin, RS | 1 |
| Sanches, IC | 1 |
| Conti, FF | 1 |
| Sartori, M | 1 |
| Irigoyen, MC | 1 |
| De Angelis, K | 1 |
| Grama, CN | 1 |
| Suryanarayana, P | 1 |
| Patil, MA | 1 |
| Raghu, G | 1 |
| Balakrishna, N | 1 |
| Kumar, MN | 1 |
| Reddy, GB | 1 |
| Di, J | 1 |
| Price, J | 1 |
| Gu, X | 1 |
| Jiang, X | 1 |
| Jing, Y | 1 |
| Arbeláez, AM | 1 |
| Cryer, PE | 1 |
| Aveseh, M | 1 |
| Nikooie, R | 2 |
| Sheibani, V | 1 |
| Esmaeili-Mahani, S | 1 |
| Shahverdi, S | 1 |
| Hajimiri, M | 1 |
| Esfandiari, MA | 1 |
| Larijani, B | 1 |
| Rajabiani, A | 1 |
| Dehpour, AR | 1 |
| Gharehaghaji, AA | 1 |
| Daneshyar, S | 1 |
| Gharakhanlou, R | 1 |
| Forutan, Y | 1 |
| Patterson, E | 1 |
| Marques, TM | 1 |
| O'Sullivan, O | 1 |
| Fitzgerald, P | 1 |
| Fitzgerald, GF | 1 |
| Cotter, PD | 1 |
| Dinan, TG | 1 |
| Cryan, JF | 1 |
| Stanton, C | 1 |
| Ross, RP | 1 |
| Lee, CH | 2 |
| Chang, SH | 2 |
| Chen, WJ | 2 |
| Hung, KC | 2 |
| Lin, YH | 1 |
| Liu, SJ | 2 |
| Hsieh, MJ | 1 |
| Pang, JH | 1 |
| Juang, JH | 2 |
| Chen, XM | 1 |
| Rawat, S | 1 |
| Gupta, P | 1 |
| Kumar, A | 1 |
| Garg, P | 1 |
| Suri, CR | 1 |
| Sahoo, DK | 1 |
| Corvino, SB | 1 |
| Netto, AO | 1 |
| Sinzato, YK | 1 |
| Campos, KE | 1 |
| Calderon, IM | 1 |
| Rudge, MV | 1 |
| Volpato, GT | 1 |
| Zambrano, E | 1 |
| Damasceno, DC | 1 |
| Malathi, S | 1 |
| Nandhakumar, P | 1 |
| Pandiyan, V | 1 |
| Webster, TJ | 1 |
| Balasubramanian, S | 1 |
| Chien, CT | 1 |
| Jou, MJ | 1 |
| Cheng, TY | 1 |
| Yang, CH | 1 |
| Yu, TY | 1 |
| Li, PC | 1 |
| Sheng, J | 2 |
| Han, L | 2 |
| Qin, J | 2 |
| Ru, G | 2 |
| Li, R | 2 |
| Wu, L | 1 |
| Cui, D | 1 |
| Yang, P | 2 |
| He, Y | 1 |
| Wang, J | 2 |
| Liu, KS | 1 |
| Pang, JS | 1 |
| Chou, CC | 1 |
| Chang, PC | 1 |
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| Osilesi, O | 1 |
| Knehans, A | 1 |
| Reiser, S | 1 |
| Cirkel, U | 1 |
| Burkart, W | 1 |
| Stähler, E | 1 |
| Buchholz, R | 1 |
| Ward, K | 1 |
| Brimijoin, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults[NCT03520569] | Early Phase 1 | 15 participants (Actual) | Interventional | 2019-02-04 | Completed | ||
| Determining the Factors That Affects Emergency Department Visits of Hyperglycemic Patients in 30 Days.[NCT04665128] | 120 participants (Anticipated) | Observational | 2020-12-15 | Recruiting | |||
| Phase 1 Study To Determine the Effects of Short Term Near-infrared Light (NIR) Therapy on Anatomic and Functional Abnormalities of Diabetic Macular Edema, and Assess Safety of Short Term Near-infrared Light Therapy in Eyes With Diabetic Macular Edema.[NCT00846092] | Phase 1 | 4 participants (Actual) | Interventional | 2007-11-30 | Completed | ||
| A Double-Blind, Placebo-Controlled Trial of Rosiglitazone for Clozapine Induced Glucose Metabolism Impairment: Bergman's Minimal Model Analysis[NCT00337350] | Phase 4 | 20 participants (Actual) | Interventional | 2003-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The augmentation index (AIx) measured at the radial artery is a measure of systemic arterial stiffness, and is defined as the ratio of augmentation (Δ P) to central pulse pressure and expressed as percent. AIx = (ΔP/PP) x 100, where P = pressure and PP = Pulse Pressure. Higher percentages indicate increased arterial stiffness. (NCT03520569)
Timeframe: baseline and after 2 hour insulin clamp
| Intervention | percentage (Mean) |
|---|---|
| Octreotide- Euglycemia | -4.15 |
| Octreotide - Euglycemia- Insulin Clamp | -2.23 |
| Octreotide- Hyperglycemia | -4.80 |
| Octreotide- Hyperglycemia - Insulin Clamp | -8.45 |
Flow mediated dilation measures the change in brachial diameter in response to 5 minutes of ischemia using B-mode ultrasound. It provides an index of nitric oxide generation by the endothelium . (NCT03520569)
Timeframe: baseline and after 2 hour insulin clamp
| Intervention | % change (Mean) |
|---|---|
| Octreotide- Euglycemia | 11.8 |
| Octreotide - Euglycemia- Insulin Clamp | 11.8 |
| Octreotide- Hyperglycemia | 8.9 |
| Octreotide- Hyperglycemia - Insulin Clamp | 8.95 |
The time required for a blood pressure wave to travel from the carotid to the femoral artery was measured in meter/sec. This is a measurement of central artery stiffness. Higher numbers indicate stiffer vessels (NCT03520569)
Timeframe: baseline and after 2 hour insulin clamp
| Intervention | m/sec (Mean) |
|---|---|
| Octreotide- Euglycemia | 5.21 |
| Octreotide - Euglycemia- Insulin Clamp | 5.06 |
| Octreotide- Hyperglycemia | 4.79 |
| Octreotide- Hyperglycemia - Insulin Clamp | 5.07 |
Acute insulin response to glucose (AIRG) was assessed using a Frequently Sampled Intravenous Glucose Tolerance Test (FSIVGTT), performed at Baseline and at week 8 (study endpoint). Subjects in the Rosiglitazone treatment arm were compared to subjects in the placebo treatment arm on their change in SG between Baseline and week 8. AIRG was calculated from plasma glucose and serum insulin values using the MINMOD Millennium computer program. AIRG measures the acute(0-10 min) beta cell response to a glucose load calculated by the areas under the curve higher than basal insulin values. The AIRG was assessed as the incremental area under the curve (calculated by the trapezoid rule) from 0 to 10 min of the FSIVGTT. (NCT00337350)
Timeframe: baseline, week 8
| Intervention | Units/mL per 10 minutes (Mean) |
|---|---|
| Rosiglitazone | -151 |
| Placebo | 19 |
Insulin Sensitivity (IS) was assessed using a Frequently Sampled Intravenous Glucose Tolerance Test (FSIVGTT), performed at Baseline and at week 8 (study endpoint). Subjects in the Rosiglitazone treatment arm were compared to subjects in the placebo treatment arm on their change in IS between Baseline and week 8. SI was calculated from plasma glucose and serum insulin values using the MINMOD Millennium computer program. SI represents the increase in net fractional glucose clearance rate per unit change in serum insulin concentration after the intravenous glucose load (microUnits/mL). (NCT00337350)
Timeframe: baseline, week 8
| Intervention | microUnits/mL (Mean) |
|---|---|
| Rosiglitazone | 3.2 |
| Placebo | 0.4 |
Glucose utilization (SG) was assessed using a Frequently Sampled Intravenous Glucose Tolerance Test (FSIVGTT), performed at Baseline and at week 8 (study endpoint). Subjects in the Rosiglitazone treatment arm were compared to subjects in the placebo treatment arm on their change in SG between Baseline and week 8. SG was calculated from plasma glucose and serum insulin values using the MINMOD Millennium computer program. SG represents the net fractional glucose clearance rate because of the increase in glucose independent of any increase in circulating insulin concentrations above baseline. (NCT00337350)
Timeframe: baseline, week 8
| Intervention | min^-1 (Mean) |
|---|---|
| Rosiglitazone | .002 |
| Placebo | -0.01 |
1 review available for lactic acid and Alloxan Diabetes
| Article | Year |
|---|---|
Progress in oral insulin delivery by PLGA nanoparticles for the management of diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Carriers; Humans; Insulin; | 2023 |
247 other studies available for lactic acid and Alloxan Diabetes
| Article | Year |
|---|---|
A Novel Metabolic Reprogramming Strategy for the Treatment of Diabetes-Associated Breast Cancer.
Topics: Animals; Antineoplastic Agents, Alkylating; Breast Neoplasms; Diabetes Mellitus, Experimental; Disea | 2022 |
Cadmium exposure decreases fasting blood glucose levels and exacerbates type-2 diabetes in a mouse model.
Topics: Animals; Blood Glucose; Cadmium; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease | 2022 |
Controlled synthesis of in-situ gold nanoparticles onto chitosan functionalized PLGA nanoparticles for oral insulin delivery.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Glycols; Gold; Insulin; Lactic Ac | 2022 |
Effects of Fibroblast Growth Factor 21 on Lactate Uptake and Usage in Mice with Diabetes-Associated Cognitive Decline.
Topics: Animals; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Fibroblast Growth Factors; Humans; | 2022 |
Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease.
Topics: Animals; Diabetes Mellitus, Experimental; Lactic Acid; Mammals; Mice; Mitochondria | 2023 |
Hyperpolarized [1-
Topics: Agmatine; Animals; Brain; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Lactic Acid; M | 2023 |
Protective role of adiponectin against testicular impairment in high-fat diet/streptozotocin-induced type 2 diabetic mice.
Topics: Adiponectin; Animals; Antioxidants; Diabetes Mellitus, Experimental; Glucose; Glucose Transport Prot | 2020 |
Malaysian propolis and metformin mitigate subfertility in streptozotocin-induced diabetic male rats by targeting steroidogenesis, testicular lactate transport, spermatogenesis and mating behaviour.
Topics: Animals; Diabetes Mellitus, Experimental; Fertility; Infertility, Male; Lactic Acid; Male; Metformin | 2020 |
Exercise enhances cardiac function by improving mitochondrial dysfunction and maintaining energy homoeostasis in the development of diabetic cardiomyopathy.
Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Blood Pressure; Cells, Cultured; Dia | 2020 |
Lactate accelerates vascular calcification through NR4A1-regulated mitochondrial fission and BNIP3-related mitophagy.
Topics: Animals; Aorta; Bone Morphogenetic Protein 2; Cholecalciferol; Core Binding Factor Alpha 1 Subunit; | 2020 |
Citrus fruit-derived flavonoid naringenin and the expression of hepatic organic cation transporter 1 protein in diabetic rats treated with metformin.
Topics: Animals; Blood Glucose; Citrus; Diabetes Mellitus, Experimental; Flavanones; Flavonoids; Hypoglycemi | 2020 |
Reducing monocarboxylate transporter MCT1 worsens experimental diabetic peripheral neuropathy.
Topics: Animals; Axons; Behavior, Animal; Demyelinating Diseases; Diabetes Mellitus, Experimental; Diabetic | 2020 |
Satellite glia as a critical component of diabetic neuropathy: Role of lipocalin-2 and pyruvate dehydrogenase kinase-2 axis in the dorsal root ganglion.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Ganglia, Spinal; Inflammation; Lact | 2021 |
Increase in brain l-lactate enhances fear memory in diabetic mice: Involvement of glutamate neurons.
Topics: Amygdala; Animals; Anxiety; Brain; Diabetes Mellitus, Experimental; Excitatory Amino Acid Antagonist | 2021 |
Hyperbaric oxygen therapy reduces renal lactate production.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Female; Hyperbaric Oxygenation; Ki | 2017 |
Preparation of poly(lactic-co-glycolic acid) and chitosan composite nanocarriers via electrostatic self assembly for oral delivery of insulin.
Topics: Administration, Oral; Animals; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Insulin; La | 2017 |
Decreased expression of orexin 1 receptor in adult mice testes during alloxan-induced diabetes mellitus perturbs testicular steroidogenesis and glucose homeostasis.
Topics: Alloxan; Animals; Apoptosis; Body Weight; Caspase 3; Diabetes Mellitus, Experimental; Gene Expressio | 2017 |
Oxamate Enhances the Anti-Inflammatory and Insulin-Sensitizing Effects of Metformin in Diabetic Mice.
Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Cytokines; Diabetes Mellitus, Experimental; Diabet | 2017 |
Construction of functional pancreatic artificial islet tissue composed of fibroblast-modified polylactic- co-glycolic acid membrane and pancreatic stem cells.
Topics: Animals; Biocompatible Materials; Cell Differentiation; Diabetes Mellitus, Experimental; Islets of L | 2017 |
Microspheres for the oral delivery of insulin: preparation, evaluation and hypoglycaemic effect in streptozotocin-induced diabetic rats.
Topics: Administration, Oral; Animals; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulin; Lactic | 2018 |
Insulin-loaded PLGA microspheres for glucose-responsive release.
Topics: Animals; Diabetes Mellitus, Experimental; Glucose; Insulin; Lactic Acid; Mice; Microspheres; Particl | 2017 |
Delivery of antagomiR204-conjugated gold nanoparticles from PLGA sheets and its implication in promoting osseointegration of titanium implant in type 2 diabetes mellitus.
Topics: Alkaline Phosphatase; Animals; Antagomirs; Bone and Bones; Cell Adhesion; Cell Death; Cell Survival; | 2017 |
Surface-modified PLGA nanoparticles with chitosan for oral delivery of tolbutamide.
Topics: Administration, Oral; Animals; Blood Glucose; Cell Survival; Chitosan; Diabetes Mellitus, Experiment | 2018 |
Tissue adhesive FK506-loaded polymeric nanoparticles for multi-layered nano-shielding of pancreatic islets to enhance xenograft survival in a diabetic mouse model.
Topics: Animals; Coated Materials, Biocompatible; Collagen; Diabetes Mellitus, Experimental; Dihydroxyphenyl | 2018 |
Single-Droplet Multiplex Bioassay on a Robust and Stretchable Extreme Wetting Substrate through Vacuum-Based Droplet Manipulation.
Topics: Animals; Biological Assay; Colorimetry; Diabetes Mellitus, Experimental; Dimethylpolysiloxanes; Gluc | 2018 |
Non-invasive detection of divergent metabolic signals in insulin deficiency vs. insulin resistance in vivo.
Topics: Alanine; Animals; Diabetes Mellitus, Experimental; Gluconeogenesis; Insulin; Insulin Resistance; Kid | 2018 |
Oral insulin delivery, the challenge to increase insulin bioavailability: Influence of surface charge in nanoparticle system.
Topics: Animals; Biological Availability; Blood Glucose; Cell Line; Cell Survival; Coculture Techniques; Dia | 2018 |
Acidosis mediates recurrent hypoglycemia-induced increase in ischemic brain injury in treated diabetic rats.
Topics: Acidosis; Acrylamides; Animals; Brain Ischemia; CA1 Region, Hippocampal; Central Nervous System Agen | 2018 |
Balanites aegyptiaca ameliorates insulin secretion and decreases pancreatic apoptosis in diabetic rats: Role of SAPK/JNK pathway.
Topics: Animals; Apoptosis; Balanites; Blood Glucose; Chromatography, Liquid; Diabetes Mellitus, Experimenta | 2018 |
Effect of photobiomodulation therapy on oxidative stress markers of gastrocnemius muscle of diabetic rats subjected to high-intensity exercise.
Topics: Animals; Biomarkers; Catalase; Diabetes Mellitus, Experimental; Glutathione Peroxidase; Lactic Acid; | 2018 |
Metabolomic Analysis Identifies Lactate as an Important Pathogenic Factor in Diabetes-associated Cognitive Decline Rats.
Topics: Analysis of Variance; Animals; Cognitive Dysfunction; Cyclic AMP Response Element-Binding Protein; C | 2018 |
Targeted folate-conjugated pluronic P85/poly(lactide-co-glycolide) polymersome for the oral delivery of insulin.
Topics: Administration, Oral; Animals; Caco-2 Cells; Cell Proliferation; Diabetes Mellitus, Experimental; Fl | 2018 |
Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes.
Topics: Adenosine Triphosphate; Administration, Intranasal; Animals; Brain; Coumaric Acids; Dementia; Diabet | 2019 |
Inhibiting hepatic gluconeogenesis by chitosan lactate nanoparticles containing CRTC2 siRNA targeted by poly(ethylene glycol)-glycyrrhetinic acid.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Gene Expression; Gluconeogenesis; Glycyrrhetinic | 2019 |
Metformin mitigates impaired testicular lactate transport/utilisation and improves sexual behaviour in streptozotocin-induced diabetic rats.
Topics: Animals; Biological Transport; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Glucose T | 2021 |
High Intrarenal Lactate Production Inhibits the Renal Pseudohypoxic Response to Acutely Induced Hypoxia in Diabetes.
Topics: Acute Disease; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Hypoxia; Ki | 2019 |
Exenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognition Disorders; Diabetes Mellitus, Ex | 2013 |
25-Hydroxyvitamin D(3)-loaded PLA microspheres: in vitro characterization and application in diabetic periodontitis models.
Topics: Alveolar Bone Loss; Animals; Calcifediol; Cell Survival; Cells, Cultured; Chemistry, Pharmaceutical; | 2013 |
Dysfunction of membrane-receptor system of blood cells and kidney tissue in experimental diabetes mellitus.
Topics: Acidosis, Lactic; Adenosine Triphosphate; Animals; Blood Glucose; Cell Membrane; Diabetes Mellitus, | 2013 |
Enhanced function of immuno-isolated islets in diabetes therapy by co-encapsulation with an anti-inflammatory drug.
Topics: Animals; Anti-Inflammatory Agents; Capsules; Cathepsins; Diabetes Mellitus, Experimental; Fibrosis; | 2013 |
Insulin concentrations in cerebellum and body balance in diabetic male rats: aerobic training effects.
Topics: Aerobiosis; Analysis of Variance; Animals; Blood Glucose; Cerebellum; Conditioning, Psychological; D | 2013 |
rhEGF-loaded PLGA-Alginate microspheres enhance the healing of full-thickness excisional wounds in diabetised Wistar rats.
Topics: 3T3 Cells; Alginates; Animals; Cell Movement; Cell Proliferation; Diabetes Mellitus, Experimental; E | 2013 |
Lactate-induced release of GABA in the ventromedial hypothalamus contributes to counterregulatory failure in recurrent hypoglycemia and diabetes.
Topics: Animals; Bicuculline; Coumaric Acids; Diabetes Mellitus, Experimental; Diazoxide; GABA Antagonists; | 2013 |
Standardization of resistance exercise training: effects in diabetic ovariectomized rats.
Topics: Animals; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus, Experimental; Female; Fructo | 2014 |
Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model.
Topics: Aldehyde Reductase; Animals; Antioxidants; Biocompatible Materials; Biodegradation, Environmental; B | 2013 |
Ultrasound-triggered regulation of blood glucose levels using injectable nano-network.
Topics: Alginates; Animals; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Glucuro | 2014 |
Lactate and the mechanism of hypoglycemia-associated autonomic failure in diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; gamma-Aminobutyric Acid; Hypoglycemia; Lactic Acid; Male; | 2013 |
Endurance training increases brain lactate uptake during hypoglycemia by up regulation of brain lactate transporters.
Topics: Animals; Biological Transport; Cerebral Cortex; Diabetes Mellitus, Experimental; Gene Expression; Hi | 2014 |
Fabrication and structure analysis of poly(lactide-co-glycolic acid)/silk fibroin hybrid scaffold for wound dressing applications.
Topics: Animals; Bandages; Cell Line; Diabetes Mellitus, Experimental; Fibroblasts; Fibroins; Lactic Acid; M | 2014 |
The effect of high-fat diet and streptozotocin-induced diabetes and endurance training on plasma levels of calcitonin gene-related peptide and lactate in rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Diabetes Mellitus, Experimental; Diet, High-Fat; Lactic Ac | 2014 |
Streptozotocin-induced type-1-diabetes disease onset in Sprague-Dawley rats is associated with an altered intestinal microbiota composition and decreased diversity.
Topics: Animals; Antibiotics, Antineoplastic; Biodiversity; Diabetes Mellitus, Experimental; Diabetes Mellit | 2015 |
Augmentation of diabetic wound healing and enhancement of collagen content using nanofibrous glucophage-loaded collagen/PLGA scaffold membranes.
Topics: Animals; Collagen; Diabetes Mellitus, Experimental; Drug Administration Routes; Hypoglycemic Agents; | 2015 |
Attenuation of inflammatory response by 25- hydroxyvitamin D3-loaded polylactic acid microspheres in treatment of periodontitis in diabetic rats.
Topics: Administration, Topical; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Animals; Anti-In | 2014 |
Molecular mechanism of poly(vinyl alcohol) mediated prevention of aggregation and stabilization of insulin in nanoparticles.
Topics: Acrylamides; Animals; Calorimetry, Differential Scanning; Cattle; Chlorides; Circular Dichroism; Dia | 2015 |
Intrauterine Growth Restricted Rats Exercised at Pregnancy: Maternal-Fetal Repercussions.
Topics: Acidosis, Lactic; Animals; Biomarkers; Birth Weight; Blood Glucose; Diabetes Mellitus, Experimental; | 2015 |
Novel PLGA-based nanoparticles for the oral delivery of insulin.
Topics: Administration, Oral; alpha-Tocopherol; Animals; Diabetes Mellitus, Experimental; Drug Carriers; Emu | 2015 |
Exendin-4-loaded PLGA microspheres relieve cerebral ischemia/reperfusion injury and neurologic deficits through long-lasting bioactivity-mediated phosphorylated Akt/eNOS signaling in rats.
Topics: Animals; Brain Ischemia; Carotid Arteries; Carotid Stenosis; Cerebrovascular Circulation; Cognition | 2015 |
N-trimethyl chitosan chloride-coated PLGA nanoparticles overcoming multiple barriers to oral insulin absorption.
Topics: Administration, Oral; Animals; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Drug Delive | 2015 |
Promoting Diabetic Wound Therapy Using Biodegradable rhPDGF-Loaded Nanofibrous Membranes: CONSORT-Compliant Article.
Topics: Absorbable Implants; Animals; Becaplermin; Diabetes Mellitus, Experimental; Enzyme-Linked Immunosorb | 2015 |
Pyruvate Dehydrogenase Kinase-mediated Glycolytic Metabolic Shift in the Dorsal Root Ganglion Drives Painful Diabetic Neuropathy.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Ganglia, Spinal; G | 2016 |
Dextran-b-poly(lactide-co-glycolide) polymersome for oral delivery of insulin: In vitro and in vivo evaluation.
Topics: Administration, Oral; Animals; Blood Glucose; Dextrans; Diabetes Mellitus, Experimental; Dogs; Drug | 2016 |
Improvement of islet engrafts by enhanced angiogenesis and microparticle-mediated oxygenation.
Topics: Animals; Blood Glucose; Catalase; Cell Hypoxia; Cell Line; Diabetes Mellitus, Experimental; Enzymes, | 2016 |
Preparation and Evaluations of Mangiferin-Loaded PLGA Scaffolds for Alveolar Bone Repair Treatment Under the Diabetic Condition.
Topics: Alveolar Bone Loss; Animals; Bone Regeneration; Delayed-Action Preparations; Diabetes Mellitus, Expe | 2017 |
Enhancing insulin oral absorption by using mucoadhesive nanoparticles loaded with LMWP-linked insulin conjugates.
Topics: Adhesiveness; Administration, Oral; Animals; Blood Glucose; Cell Line, Tumor; Cell-Penetrating Pepti | 2016 |
Liraglutide-loaded poly(lactic-co-glycolic acid) microspheres: Preparation and in vivo evaluation.
Topics: Animals; Blood Glucose; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Diabetes Melli | 2016 |
Novel insights into development of diabetic bladder disorder provided by metabolomic analysis of the rat nondiabetic and diabetic detrusor and urothelial layer.
Topics: Amino Acids, Branched-Chain; Animals; Bile Acids and Salts; Case-Control Studies; Citric Acid Cycle; | 2016 |
Effects of Pluronic F127-PEG multi-gel-core on the release profile and pharmacodynamics of Exenatide loaded in PLGA microspheres.
Topics: Animals; Biocompatible Materials; Diabetes Mellitus, Experimental; Drug Delivery Systems; Drug Liber | 2016 |
Metabolic effects of basic fibroblast growth factor in streptozotocin-induced diabetic rats: A
Topics: Amino Acids; Animals; Blood Glucose; Choline; Citric Acid; Diabetes Mellitus, Experimental; Discrimi | 2016 |
Hydrophilic poly (ethylene glycol) capped poly (lactic-co-glycolic) acid nanoparticles for subcutaneous delivery of insulin in diabetic rats.
Topics: Animals; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Drug Carriers; Drug Compounding; | 2017 |
Multifunctional Composite Microcapsules for Oral Delivery of Insulin.
Topics: Administration, Oral; Animals; Capsules; Diabetes Mellitus, Experimental; Drug Liberation; Insulin; | 2016 |
Multicomponent Injectable Hydrogels for Antigen-Specific Tolerogenic Immune Modulation.
Topics: Animals; Antigens; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Hydrogels; Immune Tol | 2017 |
Effect of poly(ethylene glycol) content and formulation parameters on particulate properties and intraperitoneal delivery of insulin from PLGA nanoparticles prepared using the double-emulsion evaporation procedure.
Topics: Animals; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Emulsions; Hypoglycemic Agent | 2018 |
Differential impact of adipokines derived from primary adipocytes of wild-type versus streptozotocin-induced diabetic rats on glucose and fatty acid metabolism in cardiomyocytes.
Topics: Adipocytes; Adipokines; Animals; Animals, Newborn; Cells, Cultured; Culture Media, Conditioned; Diab | 2008 |
Evaluation of parenteral depot insulin formulation using PLGA and PLA microparticles.
Topics: Animals; Diabetes Mellitus, Experimental; Drug Carriers; Drug Delivery Systems; Female; Humans; Hypo | 2009 |
Repair effect of diabetic ulcers with recombinant human epidermal growth factor loaded by sustained-release microspheres.
Topics: Animals; Biocompatible Materials; Cell Line; Cell Proliferation; Delayed-Action Preparations; Diabet | 2008 |
The reversal of hyperglycaemia in diabetic mice using PLGA scaffolds seeded with islet-like cells derived from human embryonic stem cells.
Topics: Animals; Biomarkers; Blood Glucose; Cell Differentiation; Cell Shape; Diabetes Mellitus, Experimenta | 2009 |
Insulin-loaded PLGA/cyclodextrin large porous particles with improved aerosolization properties: in vivo deposition and hypoglycaemic activity after delivery to rat lungs.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Administration, Inhalation; Aerosols; Animals; beta-Cyclodextrins | 2009 |
Effects of exercise training on hippocampus concentrations of insulin and IGF-1 in diabetic rats.
Topics: Analysis of Variance; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Exercise Test; Glycog | 2009 |
A novel DPP-IV-resistant analog of glucagon-like peptide-1 (GLP-1): KGLP-1 alone or in combination with long-acting PLGA microspheres.
Topics: Animals; Cell Line; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Drug Compounding; Femal | 2009 |
Effects of poly (lactic-co-glycolic acid) as a co-emulsifier on the preparation and hypoglycaemic activity of insulin-loaded solid lipid nanoparticles.
Topics: Analysis of Variance; Animals; Blood Glucose; Castor Oil; Chemical Phenomena; Diabetes Mellitus, Exp | 2009 |
Insulin-S.O (sodium oleate) complex-loaded PLGA nanoparticles: formulation, characterization and in vivo evaluation.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Hypoglycemic Agents | 2010 |
Pharmacokinetics and pharmacodynamics of controlled release insulin loaded PLGA microcapsules using dry powder inhaler in diabetic rats.
Topics: Administration, Inhalation; Animals; Blood Glucose; Capsules; Diabetes Mellitus, Experimental; Drug | 2010 |
[Effect of sustained release of recombinant rat insulin-like growth factor-1 from poly (lactide-CO-glycolide ) microspheres on bone formation in the peri-implant areas in Goto-Kakizaki rats with type 2 diabetes].
Topics: Animals; Delayed-Action Preparations; Dental Implants; Diabetes Mellitus, Experimental; Diabetes Mel | 2010 |
Feasibility of localized immunosuppression: 2. PLA microspheres for the sustained local delivery of a soft immunosuppressant.
Topics: Algorithms; Androstadienes; Animals; Cell Line; Cell Survival; Delayed-Action Preparations; Diabetes | 2010 |
Repaglinide-loaded long-circulating biodegradable nanoparticles: rational approach for the management of type 2 diabetes mellitus.
Topics: Administration, Oral; Animals; Blood Glucose; Carbamates; Chemistry, Pharmaceutical; Delayed-Action | 2009 |
Exercise test and glucose homeostasis in rats treated with alloxan during the neonatal period or fed a high calorie diet.
Topics: Age Factors; Aging; Animals; Animals, Newborn; Biomarkers; Blood Glucose; Diabetes Mellitus, Experim | 2009 |
Evaluation of the impact of diabetes on retinal metabolites by NMR spectroscopy.
Topics: Animals; Blood Glucose; Deoxyglucose; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Glucose | 2010 |
Preparation, characterization, and pharmacodynamics of exenatide-loaded poly(DL-lactic-co-glycolic acid) microspheres.
Topics: Animals; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Exenatide; Hypoglycemic Agent | 2010 |
Determination of time-dependent accumulation of D-lactate in the streptozotocin-induced diabetic rat kidney by column-switching HPLC with fluorescence detection.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Histocyt | 2011 |
Preparation of ONO-1301-loaded poly(lactide-co-glycolide) microspheres and their effect on nerve conduction velocity.
Topics: Animals; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Diabetic Neuropathie | 2011 |
[Comparative characteristic of energy supply disturbances in arterial and venous walls of rabbits with alloxan diabetes and monoiodacetate intoxication].
Topics: Adenosine Triphosphate; Alloxan; Animals; Aorta, Thoracic; Diabetes Mellitus, Experimental; Energy M | 2011 |
FTY720-loaded poly(DL-lactide-co-glycolide) electrospun scaffold significantly increases microvessel density over 7 days in streptozotocin-induced diabetic C57b16/J mice: preliminary results.
Topics: Animals; Automation; Biocompatible Materials; Diabetes Mellitus, Experimental; Drug Delivery Systems | 2011 |
Preparation, characterization and in vivo evaluation of pH-sensitive oral insulin-loaded poly(lactic-co-glycolicacid) nanoparticles.
Topics: Administration, Oral; Animals; Biocompatible Materials; Blood Glucose; Diabetes Mellitus, Experiment | 2012 |
Antacid co-encapsulated polyester nanoparticles for peroral delivery of insulin: development, pharmacokinetics, biodistribution and pharmacodynamics.
Topics: Administration, Oral; Animals; Antacids; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemi | 2013 |
HP55-coated capsule containing PLGA/RS nanoparticles for oral delivery of insulin.
Topics: Acrylic Resins; Administration, Oral; Animals; Blood Glucose; Capsules; Diabetes Mellitus, Experimen | 2012 |
Effects of hyperglycemia and effects of ketosis on cerebral perfusion, cerebral water distribution, and cerebral metabolism.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Brain Edema; Cerebrum; Diabetes Mellitus, Experiment | 2012 |
Effect of zinc supplementation on lipid peroxidation and lactate levels in rats with diabetes induced by streptozotocin and subjected to acute swimming exercise.
Topics: Animals; Diabetes Mellitus, Experimental; Lactic Acid; Lipid Peroxidation; Male; Physical Exertion; | 2012 |
Folate-decorated PLGA nanoparticles as a rationally designed vehicle for the oral delivery of insulin.
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Carriers; Folic | 2012 |
Sustained topical delivery of insulin from fibrin gel loaded with poly(lactic-co-glycolic Acid) microspheres improves the biomechanical retention of titanium implants in type 1 diabetic rats.
Topics: Administration, Topical; Animals; Biomechanical Phenomena; Delayed-Action Preparations; Dental Impla | 2012 |
Effects of local delivery of bFGF from PLGA microspheres on osseointegration around implants in diabetic rats.
Topics: Animals; Biocompatible Materials; Dental Implants; Dental Materials; Diabetes Mellitus, Experimental | 2012 |
In vitro uptake evaluation in Caco-2 cells and in vivo results in diabetic rats of insulin-loaded PLGA nanoparticles.
Topics: Animals; Blood Glucose; Caco-2 Cells; Diabetes Mellitus, Experimental; Drug Carriers; Endocytosis; H | 2012 |
Multi-arm histidine copolymer for controlled release of insulin from poly(lactide-co-glycolide) microsphere.
Topics: Animals; Blood Glucose; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Histidine; Hyp | 2012 |
The use of native chemical functional groups presented by wound beds for the covalent attachment of polymeric microcarriers of bioactive factors.
Topics: Animals; Catechols; Dermis; Diabetes Mellitus, Experimental; Drug Carriers; Lactic Acid; Male; Malei | 2013 |
A syndrome of severe hypoglycemia and acidosis in young immunosuppressed diabetic monkeys and pigs-association with sepsis.
Topics: Acidosis; Animals; Bacteria; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; | 2012 |
Assessment of early diabetic renal changes with hyperpolarized [1-(13) C]pyruvate.
Topics: Animals; Bicarbonates; Carbon Isotopes; Diabetes Mellitus, Experimental; Female; Kidney; L-Lactate D | 2013 |
Polymeric "smart" coatings to prevent foreign body response to implantable biosensors.
Topics: Animals; Anti-Inflammatory Agents; Biosensing Techniques; Blood Glucose; Coated Materials, Biocompat | 2013 |
Haemodynamic and metabolic effects of low daily dose sulphonylureas in diabetic dog hearts.
Topics: Animals; Blood Glucose; Blood Pressure; Coronary Circulation; Diabetes Mellitus, Experimental; Dogs; | 2002 |
[Study on preparation and oral efficacy of insulin-loaded poly(lactic-co-glycolic acid) nanoparticles].
Topics: Administration, Oral; Animals; Biological Availability; Blood Glucose; Diabetes Mellitus, Experiment | 2002 |
Exercise training alleviates MCT1 and MCT4 reductions in heart and skeletal muscles of STZ-induced diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Lactic Acid; Male; Monocarboxy | 2003 |
Preparation and in vitro/in vivo evaluation of insulin-loaded poly(acryloyl-hydroxyethyl starch)-PLGA composite microspheres.
Topics: Acrylic Resins; Animals; Diabetes Mellitus, Experimental; Drug Carriers; Drug Compounding; Drug Stab | 2003 |
Potential applications of polymeric microsphere suspension as subcutaneous depot for insulin.
Topics: Animals; Area Under Curve; Blood Glucose; Delayed-Action Preparations; Diabetes Mellitus, Experiment | 2003 |
Shift in metabolic substrate uptake by the heart during development of alloxan-induced diabetes.
Topics: 3-Hydroxybutyric Acid; Alloxan; Animals; Blood Glucose; Blood Pressure; Body Weight; Carbon Dioxide; | 2003 |
Metabolic, endocrine, and immune effects of stress hyperglycemia in a rabbit model of prolonged critical illness.
Topics: Alloxan; Animals; Blood Gas Analysis; Blood Glucose; Body Weight; Burns; Critical Illness; Diabetes | 2003 |
[On the metabolism of injured tissues. 11. Pyridine nucleotide content, lactic acid content, and pyruvic acid content of the liver of normal and alloxan-diabetic mice after glucose and fructose loading].
Topics: Alloxan; Animals; Coenzymes; Diabetes Mellitus, Experimental; Fructose; Glucose; Lactates; Lactic Ac | 1960 |
[Enhancement of gastrointestinal absorption of chitosan-coated insulin-loaded poly (lactic-co-glycolic acid) nanoparticles].
Topics: Animals; Blood Glucose; Chitin; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Drug Deliv | 2003 |
Effect of fructose on lipogenesis from lactate and acetate in diabetic liver.
Topics: Acetates; Animals; Diabetes Mellitus, Experimental; Fatty Acids; Fructose; Lactates; Lactic Acid; Li | 1952 |
The effect of hyperglycemia on experimental retinal ischemia.
Topics: Animals; Blood Glucose; Cyclophilins; Deoxyglucose; Diabetes Mellitus, Experimental; Electroretinogr | 2004 |
Isotopic discrimination between D-[1-(13)C]fructose and D-[2-(13)C]fructose in rat liver cells.
Topics: Alanine; Animals; Carbon Isotopes; Cell Separation; Deuterium; Diabetes Mellitus, Experimental; Fruc | 2004 |
Biodegradable triblock copolymer microspheres based on thermosensitive sol-gel transition.
Topics: Animals; Biodegradation, Environmental; Diabetes Mellitus, Experimental; Emulsions; Hypoglycemic Age | 2004 |
Optimum formulation for sustained-release insulin.
Topics: Animals; Capsules; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Glycerol; Injection | 2004 |
The effect of global brain ischemia in normal and diabetic animals: the influence of calcium channel blockers.
Topics: Adenosine Triphosphate; Animals; Brain Chemistry; Brain Ischemia; Calcium; Calcium Channel Blockers; | 2004 |
Subconjunctivally administered celecoxib-PLGA microparticles sustain retinal drug levels and alleviate diabetes-induced oxidative stress in a rat model.
Topics: Aldehydes; Animals; Celecoxib; Conjunctiva; Cyclooxygenase Inhibitors; Delayed-Action Preparations; | 2005 |
PEGylated insulin in PLGA microparticles. In vivo and in vitro analysis.
Topics: Animals; Circular Dichroism; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Glycolate | 2005 |
Early pre-diabetic state alters adaptation of myocardial glucose metabolism during ischemia in rats.
Topics: Adaptation, Physiological; Animals; Diabetes Mellitus, Experimental; Fructose; Glucose; Glucose Tran | 2005 |
The effects of peroxovanadate and peroxovanadyl on glucose metabolism in vivo and identification of signal transduction proteins involved in the mechanism of action in isolated soleus muscle.
Topics: Animals; Diabetes Mellitus, Experimental; Glucose; Glycogen; Hyperglycemia; Hypoglycemic Agents; Ins | 2005 |
Effect of prostaglandins against alloxan-induced diabetes mellitus.
Topics: Alloxan; Alprostadil; Animals; Antioxidants; Blood Glucose; Body Weight; Catalase; Ceruloplasmin; Di | 2006 |
Differential effect of saturated, monounsaturated, and polyunsaturated fatty acids on alloxan-induced diabetes mellitus.
Topics: Alloxan; Animals; Arachidonic Acid; Blood Glucose; Body Weight; Catalase; Ceruloplasmin; Diabetes Me | 2006 |
Hypoglycemic activity of jatrorrhizine.
Topics: Animals; Berberine; Diabetes Mellitus, Experimental; Glycolysis; Hypoglycemic Agents; L-Lactate Dehy | 2005 |
Glucose metabolism in rat retinal pigment epithelium.
Topics: Animals; Carbon Dioxide; Diabetes Mellitus, Experimental; Female; Glucose; Glycogen; Lactic Acid; Pi | 2006 |
Single periocular injection of celecoxib-PLGA microparticles inhibits diabetes-induced elevations in retinal PGE2, VEGF, and vascular leakage.
Topics: Animals; Blood-Retinal Barrier; Capillary Permeability; Celecoxib; Cell Culture Techniques; Cyclooxy | 2006 |
Reexamining the hyperglycemic pseudohypoxia hypothesis of diabetic oculopathy.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Animals; Cell Culture Techniques; Diabetes Mellitus, Exp | 2006 |
The experimental type 2 diabetes therapy glycogen phosphorylase inhibition can impair aerobic muscle function during prolonged contraction.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Female; Gluc | 2006 |
Impact of in vivo fatty acid oxidation blockade on glucose turnover and muscle glucose metabolism during low-dose AICAR infusion.
Topics: Acetyl-CoA Carboxylase; Adenosine Monophosphate; Adenosine Triphosphate; Aminoimidazole Carboxamide; | 2006 |
Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: preparation, in vitro characterization and in vivo evaluation.
Topics: Administration, Oral; Algorithms; Animals; Area Under Curve; Biological Availability; Biotransformat | 2006 |
Influence of microencapsulation method and peptide loading on formulation of poly(lactide-co-glycolide) insulin nanoparticles.
Topics: Animals; Blood Glucose; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Chromatograph | 2006 |
[Long-acting injectable microspheres of glucagon-like peptide-1].
Topics: Animals; Blood Glucose; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Glucagon-Like | 2006 |
Preparation of insulin loaded PLGA-Hp55 nanoparticles for oral delivery.
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Compounding; Dru | 2007 |
Controlled release of insulin from PLGA nanoparticles embedded within PVA hydrogels.
Topics: Animals; Coated Materials, Biocompatible; Delayed-Action Preparations; Diabetes Mellitus, Experiment | 2007 |
Beneficial effect of heme oxygenase-1 expression on myocardial ischemia-reperfusion involves an increase in adiponectin in mildly diabetic rats.
Topics: Adiponectin; Animals; bcl-X Protein; Cardiovascular Agents; Coronary Vessels; Diabetes Mellitus, Exp | 2007 |
Na+/H+ exchange inhibition with cariporide prevents alterations of coronary endothelial function in streptozotocin-induced diabetes.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Blood Glucose; Carbacho | 2008 |
Exercise improves visual deficits tested by visual evoked potentials in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Evoked Potentials, Visual; Eye | 2007 |
Preparation of glucagon-like peptide-1 loaded PLGA microspheres: characterizations, release studies and bioactivities in vitro/in vivo.
Topics: Animals; Blood Glucose; Chemistry, Pharmaceutical; Delayed-Action Preparations; Diabetes Mellitus, E | 2008 |
Improved bioavailability of orally delivered insulin using Eudragit-L30D coated PLGA microparticles.
Topics: Administration, Oral; Animals; Biological Availability; Blood Glucose; Diabetes Mellitus, Experiment | 2008 |
Effects of (-)-(R)-1-(p-hydroxyphenyl)-2-[3,4-dimethoxyphenethyl)amino]ethanol (TA-064), a new cardiotonic agent, on circulating parameters of carbohydrate and lipid metabolism in the rat.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blood Glucose; Cardiotonic Agents; D | 1984 |
Altered biochemical responses by rat Sertoli cells and peritubular cells cultured under simulated diabetic conditions.
Topics: 3-Hydroxybutyric Acid; Androgen-Binding Protein; Animals; Bicarbonates; Carrier Proteins; Cells, Cul | 1984 |
Impaired energy utilization and Na-K-ATPase in diabetic peripheral nerve.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Diabetes Mellitus, Experimental; Glucose; Inositol; La | 1984 |
Fetal and neonatal metabolism in the pup of a canine diabetic mother. Fasting circulating fuels and neonatal glucose turnover.
Topics: Amino Acids; Animals; Animals, Newborn; Diabetes Mellitus, Experimental; Dogs; Fatty Acids, Nonester | 1983 |
Metabolic responses to intraduodenal glucose loading in insulin-infused diabetic dogs.
Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Fatty | 1983 |
Glucose metabolism studied isotopically in diabetic dogs: effect of restoration of peripheral normoinsulinaemia by the artificial B cell.
Topics: Animals; Blood Glucose; Carbon Radioisotopes; Diabetes Mellitus, Experimental; Dogs; Glucagon; Gluco | 1983 |
Hormonal regulation of glucose transport in contracting skeletal muscle from normal and diabetic rats.
Topics: Animals; Biological Transport; Diabetes Mellitus, Experimental; Electric Stimulation; Epinephrine; G | 1984 |
Regulation of carbohydrate metabolism by 2,5-anhydro-D-mannitol.
Topics: Animals; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Fructosediphosphates; Glucagon; G | 1983 |
The effect of ischaemia on the activity of pyruvate dehydrogenase complex in rat heart.
Topics: Adenosine Triphosphate; Animals; Coronary Disease; Diabetes Mellitus, Experimental; Dietary Fats; He | 1984 |
Effect of tolbutamide on myocardial metabolism and mechanical performance of the diabetic rat.
Topics: Animals; Cardiac Output; Diabetes Mellitus, Experimental; Glucose; Heart; Kinetics; Lactates; Lactic | 1984 |
The development of glucose metabolism in infants of diabetic mothers.
Topics: Animals; Animals, Newborn; Blood Glucose; Diabetes Mellitus, Experimental; Female; Fetal Blood; Gluc | 1984 |
Pharmacologic effects of metformin in relation to its disposition in alloxan diabetic rats.
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose Tolerance Tes | 1983 |
Comparison of the metabolic responses to portal and peripheral infusions of insulin in diabetic dogs.
Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Gluca | 1981 |
Glucose turnover five hours following endotoxin administration to normal and diabetic rats.
Topics: Animals; Blood Pressure; Diabetes Mellitus, Experimental; Endotoxins; Escherichia coli; Glucose; Hea | 1982 |
Correction for the metabolic exchange of 14C for 12C atoms in the pathway of gluconeogenesis in vivo.
Topics: Alanine; Animals; Bicarbonates; Blood Glucose; Carbon; Carbon Radioisotopes; Citric Acid Cycle; Diab | 1982 |
Biochemical changes after surgical stress in rabbits.
Topics: Alanine; Animals; Blood Glucose; Blood Proteins; Blood Urea Nitrogen; Diabetes Mellitus, Experimenta | 1982 |
Decreased lactate transport in aortas from streptozotocin-diabetic rats.
Topics: Animals; Aorta; Biological Transport; Diabetes Mellitus, Experimental; Lactates; Lactic Acid; Male; | 1982 |
Effect of sodium dichloroacetate on dental caries in diabetic rats.
Topics: Acetates; Animals; Dental Caries; Diabetes Mellitus, Experimental; Dichloroacetic Acid; Lactates; La | 1982 |
Factors affecting tryptophan-induced hypoglycaemia in rats.
Topics: Adrenalectomy; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Hormones; Hypoglyc | 1982 |
Effects of acute experimental diabetes on composite energy metabolism in peripheral nerve axons and Schwann cells.
Topics: Adenosine Triphosphate; Animals; Axons; Diabetes Mellitus, Experimental; Energy Metabolism; Lactates | 1981 |
Activation of peritoneal macrophages during the prediabetic phase in low-dose streptozotocin-treated mice.
Topics: Amino Acid Oxidoreductases; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Interferon-ga | 1993 |
Is glycolysis impaired in erythrocytes of diabetic rats?
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Glucose; Bucladesine; Diabetes Mellitus, Experimental; E | 1993 |
Stimulation of gluconeogenesis leads to an increased rate of beta-oxidation in hepatocytes from fasted diabetic but not from fasted normal rats.
Topics: Adenosine Triphosphate; Animals; Antimycin A; Diabetes Mellitus, Experimental; Fasting; Fatty Acids; | 1995 |
Catecholamine-induced cAMP response in streptozotocin-induced diabetic rat liver.
Topics: Adipose Tissue; Animals; Colforsin; Cyclic AMP; Diabetes Mellitus, Experimental; Emaciation; Epineph | 1994 |
Insulin-independent and extremely rapid switch in the partitioning of hepatic fatty acids from oxidation to esterification in starved-refed diabetic rats. Possible roles for changes in cell pH and volume.
Topics: Animals; Carnitine O-Palmitoyltransferase; Cholesterol Esters; Diabetes Mellitus, Experimental; Este | 1995 |
Mechanisms of intracellular pH regulation during postischemic reperfusion of diabetic rat hearts.
Topics: Amiloride; Animals; Bicarbonates; Diabetes Mellitus, Experimental; HEPES; Hydrogen-Ion Concentration | 1995 |
Inhibition of sorbitol dehydrogenase. Effects on vascular and neural dysfunction in streptozocin-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Neuropathies; Eye; Fructos | 1995 |
Intracerebroventricular administration of somatostatin octapeptide counteracts the hormonal and metabolic responses to stress in normal and diabetic dogs.
Topics: Animals; Blood Glucose; Carbachol; Diabetes Mellitus, Experimental; Dogs; Fatty Acids, Nonesterified | 1994 |
Chronic gliclazide treatment affects basal and post-ischemic cardiac function in diabetic rats.
Topics: Adenosine Triphosphate; Animals; Diabetes Mellitus, Experimental; Gliclazide; Heart; Lactates; Lacti | 1994 |
Sorbitol-accumulating pyrimidine derivatives.
Topics: Animals; Behavior, Animal; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; Dose-Response R | 1994 |
Improvement of ketoacidosis in the diabetic rat after the administration of the oral antilipolytic agent GR 79236.
Topics: Adenosine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Ketoacidosis; Fatty Aci | 1994 |
Carbon sources for D-lactate formation in rat liver.
Topics: Acetoacetates; Acetone; Animals; Diabetes Mellitus, Experimental; Glucose; Glycerol; In Vitro Techni | 1994 |
Manifestations of diabetes mellitus on mouse preimplantation development: effect of elevated concentration of metabolic intermediates.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Amino Acids; Animals; Butyrates; Cleavage Stage, Ovum; Culture | 1994 |
Glucose, glycogen and triglyceride metabolism, as well as prostaglandin production in uterine strips and in embryos from diabetic pregnant rats. Influences of the presence of substrate in the incubation medium.
Topics: Alprostadil; Animals; Culture Techniques; Diabetes Mellitus, Experimental; Dinoprostone; Female; Fet | 1993 |
Ex vivo effect of insulin on normal and diabetic rat hearts hypoperfused with norepinephrine.
Topics: Animals; Cerebrovascular Circulation; Diabetes Mellitus, Experimental; Energy Metabolism; In Vitro T | 1993 |
Controlled release of insulin from plasma-irradiated sandwitch device using poly-DL-lactic acid.
Topics: Adsorption; Animals; Blood Glucose; Buffers; Diabetes Mellitus, Experimental; Injections, Subcutaneo | 1993 |
The inhibitory action of buformin, a biguanide on gluconeogenesis from alanine and its transport system in rat livers.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Alanine; Animals; Biological Transport, Active; Buformin; Cell | 1993 |
Streptozotocin-induced diabetes increases fructose 2,6-biphosphate levels and glucose metabolism in thymus lymphocytes.
Topics: Animals; Carbon Dioxide; Diabetes Mellitus, Experimental; Fructosediphosphates; Glucose; Glycogen; G | 1996 |
Experimental streptozotocin-reduced diabetes and intestinal glucose metabolism in the rat, in vivo and in vitro.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose; Glycolysis; In Vitro Tech | 1995 |
Role of high glycogen in underperfused diabetic rat hearts with added norepinephrine.
Topics: Adenosine Triphosphate; Animals; Diabetes Mellitus, Experimental; Energy Metabolism; Glycogen; Lacta | 1995 |
Metabolism of glucose, glycogen, and high-energy phosphates during transient forebrain ischemia in diabetic rats: effect of insulin treatment.
Topics: Adenosine Triphosphate; Animals; Brain; Diabetes Mellitus, Experimental; Glucose; Glycogen; Insulin; | 1996 |
Diabetogenic effects of salmon calcitonin are attributable to amylin-like activity.
Topics: Amino Acid Sequence; Amyloid; Animals; Blood Glucose; Calcitonin; Diabetes Mellitus, Experimental; D | 1995 |
Improvement of cardiac performance and metabolism in long-term diabetes mellitus after treatment with insulin [see comment].
Topics: Adenosine Triphosphate; Animals; Cardiac Output; Diabetes Mellitus, Experimental; Glucose; Heart; In | 1995 |
Decreased myocardial glucose uptake during ischemia in diabetic swine.
Topics: Animals; Blood Glucose; Coronary Circulation; Diabetes Mellitus, Experimental; Fasting; Fatty Acids, | 1997 |
Glucose transport and glucose transporter GLUT4 are regulated by product(s) of intermediary metabolism in cardiomyocytes.
Topics: 3-Hydroxybutyric Acid; 3-O-Methylglucose; Animals; Biological Transport; Cells, Cultured; Deoxygluco | 1997 |
Hepatic glucose production from L-alanine is absent in perfused liver of diabetic rats.
Topics: Alanine; Alloxan; Animals; Anti-Bacterial Agents; Diabetes Mellitus, Experimental; Gluconeogenesis; | 1997 |
Lipoic acid reduces glycemia and increases muscle GLUT4 content in streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Deoxyglucose; Diabetes Mellitus, Experimental; Glucose Transporter Type 4; I | 1997 |
Energy metabolism after ischemic preconditioning in streptozotocin-induced diabetic rat hearts.
Topics: Adenine Nucleotides; Animals; Creatine; Creatine Kinase; Diabetes Mellitus, Experimental; Energy Met | 1998 |
Changes in the redox state in the retina and brain during the onset of diabetes in rats.
Topics: Animals; Cerebral Cortex; Diabetes Mellitus, Experimental; L-Lactate Dehydrogenase; Lactic Acid; Len | 1998 |
Intramuscular 3-hydroxybutyrate levels after 60 tetani/min contraction in diabetic and non-diabetic rats.
Topics: 3-Hydroxybutyric Acid; Animals; Diabetes Mellitus, Experimental; Lactic Acid; Male; Muscle Contracti | 1998 |
Effect of L-arginine-nitric oxide system on chemical-induced diabetes mellitus.
Topics: Alloxan; Animals; Antioxidants; Arginine; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Insuli | 1998 |
Modifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin.
Topics: Animals; Citric Acid Cycle; Diabetes Mellitus, Experimental; Gluconeogenesis; Glucose; Glutamic Acid | 1999 |
Preferential inhibition of lactate oxidation relative to glucose oxidation in the rat heart following diabetes.
Topics: Analysis of Variance; Animals; Diabetes Mellitus, Experimental; Glucose; Lactic Acid; Magnetic Reson | 1999 |
Effects of anoxia on force, intracellular calcium and lactate production of urinary bladder smooth muscle from control and diabetic rats.
Topics: Animals; Calcium; Cell Hypoxia; Diabetes Mellitus, Experimental; Glucose; Intracellular Fluid; Lacti | 2000 |
Enhancement of fracture repair in rats with streptozotocin-induced diabetes by a single injection of biodegradable microcapsules containing a bone formation stimulant, TAK-778.
Topics: Animals; Benzothiepins; Biocompatible Materials; Biodegradation, Environmental; Capsules; Diabetes M | 2000 |
The effect of topical insulin on the release of excitotoxic and other amino acids from the rat cerebral cortex during streptozotocin-induced hyperglycemic ischemia.
Topics: Administration, Topical; Animals; Aspartic Acid; Blood Glucose; Brain Ischemia; Cerebral Cortex; Dia | 2000 |
Effects of the dimethyl ester on succinic acid on the hormonal and metabolic response to exercise in hereditarily diabetic starved rats.
Topics: 3-Hydroxybutyric Acid; Animals; Body Weight; Diabetes Mellitus, Experimental; Fatty Acids, Nonesteri | 2000 |
Acute diabetes modulates response to ischemia in isolated rat heart.
Topics: Animals; Arrhythmias, Cardiac; Blood Glucose; Diabetes Mellitus, Experimental; Glycogen; Heart; Hear | 2000 |
Lactate transport in rat adipocytes: identification of monocarboxylate transporter 1 (MCT1) and its modulation during streptozotocin-induced diabetes.
Topics: Adipocytes; Animals; Biological Transport; Blotting, Western; Brain; Carrier Proteins; Cell Membrane | 2000 |
Correction of hyperglycemia and insulin sensitivity by T-1095, an inhibitor of renal Na+-glucose cotransporters, in streptozotocin-induced diabetic rats.
Topics: Animals; Carbonates; Deoxyglucose; Diabetes Mellitus, Experimental; Glucosides; Hyperglycemia; Hypog | 2000 |
Low molecular weight chitosan prevents the progression of low dose streptozotocin-induced slowly progressive diabetes mellitus in mice.
Topics: Administration, Oral; Animals; Blood Glucose; Chitin; Chitosan; Diabetes Mellitus, Experimental; Dis | 2000 |
The effect of streptozotocin-induced diabetes on the release of excitotoxic and other amino acids from the ischemic rat cerebral cortex.
Topics: Acute Disease; Amino Acids; Animals; Blood Glucose; Brain Ischemia; Cerebral Cortex; Chronic Disease | 2001 |
Inhibitory effect of hyperglycemia on insulin-induced Akt/protein kinase B activation in skeletal muscle.
Topics: Animals; Biological Transport; Deoxyglucose; Diabetes Mellitus, Experimental; Enzyme Activation; Glu | 2001 |
Diabetes-induced changes in retinal NAD-redox status: pharmacological modulation and implications for pathogenesis of diabetic retinopathy.
Topics: Adrenergic alpha-Antagonists; Ammonia; Animals; Antioxidants; Cell Fractionation; Diabetes Mellitus, | 2001 |
Streptozotocin-induced diabetes decreases rat sarcolemmal lactate transport.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Down-Regulation; Glutathione P | 2001 |
Ventricular arrhythmias following coronary artery occlusion in rats: is the diabetic heart less or more sensitive to ischaemia?
Topics: Animals; Blood Glucose; Coronary Disease; Diabetes Mellitus, Experimental; Glycogen; In Vitro Techni | 2001 |
Rates of gluconeogenesis in perfused liver of alloxan-diabetic fed rats.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Fructose; Gluconeogenesis; Glucose; Glutamine; In | 2000 |
Simultaneous determination of D-lactic acid and 3-hydroxybutyric acid in rat plasma using a column-switching HPLC with fluorescent derivatization with 4-nitro-7-piperazino-2,1,3-benzoxadiazole (NBD-PZ).
Topics: 3-Hydroxybutyric Acid; Animals; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimenta | 2001 |
A novel sustained-release formulation of insulin with dramatic reduction in initial rapid release.
Topics: Animals; Biocompatible Materials; Capsules; Chemistry, Pharmaceutical; Delayed-Action Preparations; | 2002 |
Effect of endogenous beta-hydroxybutyrate on brain glucose metabolism in fetuses of diabetic rabbits, studied by (13)C magnetic resonance spectroscopy.
Topics: 3-Hydroxybutyric Acid; Amino Acids; Animals; Blood Glucose; Brain; Carbon Isotopes; Diabetes Mellitu | 2002 |
Rosiglitazone, a peroxisome proliferator-activated receptor-gamma, inhibits the Jun NH(2)-terminal kinase/activating protein 1 pathway and protects the heart from ischemia/reperfusion injury.
Topics: Animals; Cardiotonic Agents; Carrier Proteins; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 2002 |
Insulin-loaded biodegradable PLGA microcapsules: initial burst release controlled by hydrophilic additives.
Topics: Animals; Biocompatible Materials; Blood Glucose; Capsules; Crystallography, X-Ray; Delayed-Action Pr | 2002 |
Effects of streptozotocin-induced diabetes on markers of skeletal muscle metabolism and monocarboxylate transporter 1 to monocarboxylate transporter 4 transporters.
Topics: Animals; Biomarkers; Blood Glucose; Body Weight; Carrier Proteins; Citrate (si)-Synthase; Diabetes M | 2002 |
Glucose metabolism in embryos of normal and diabetic rats during organogenesis.
Topics: Animals; Diabetes Mellitus, Experimental; DNA; Embryo, Mammalian; Embryonic and Fetal Development; G | 1992 |
Effects of high levels of fatty acids on functional recovery of ischemic hearts from diabetic rats.
Topics: Adenosine Triphosphate; Animals; Coronary Disease; Diabetes Mellitus, Experimental; Diabetic Angiopa | 1992 |
Correlation of contractile dysfunction and abnormal tissue energy metabolism during hypoperfusion with norepinephrine in isolated rat hearts: differences between normal and diabetic hearts.
Topics: Adenosine Triphosphate; Animals; Diabetes Mellitus, Experimental; Energy Metabolism; Heart; Lactates | 1992 |
Concentrations of D-lactate and its related metabolic intermediates in liver, blood, and muscle of diabetic and starved rats.
Topics: Animals; Blood Chemical Analysis; Blood Glucose; Diabetes Mellitus, Experimental; Enzymes; Food Depr | 1992 |
The effects of orthovanadate, vanadyl and peroxides of vanadate on glucose metabolism in skeletal muscle preparations in vitro.
Topics: Animals; Diabetes Mellitus, Experimental; Glucose; Glycogen; Insulin; Lactates; Lactic Acid; Male; M | 1992 |
Focal and perifocal changes in tissue energy state during middle cerebral artery occlusion in normo- and hyperglycemic rats.
Topics: Adenine Nucleotides; Animals; Arterial Occlusive Diseases; Blood Pressure; Body Temperature; Brain; | 1992 |
Glucose and glutamine metabolism in rat macrophages: enhanced glycolysis and unaltered glutaminolysis in spontaneously diabetic BB rats.
Topics: Adenosine Triphosphate; Ammonia; Animals; Aspartic Acid; Diabetes Mellitus, Experimental; Female; Gl | 1991 |
Glutamine and glucose metabolism in thymocytes from normal and spontaneously diabetic BB rats.
Topics: Adenosine Triphosphate; Animals; Cell Count; Diabetes Mellitus, Experimental; Female; Glucose; Gluta | 1991 |
Enhanced 2-deoxy-D-glucose uptake and metabolism in splenocytes from diabetic and diabetes-prone BB rats. Further evidence to support prior in vivo activation.
Topics: Animals; Carbon Dioxide; Deoxyglucose; Diabetes Mellitus, Experimental; Female; Glucose; Lactates; L | 1991 |
[The effect of exertion on carbohydrate metabolism in myocardium of animals with experimental diabetes].
Topics: Animals; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Lactates; Lactic Acid; Myocardium | 1990 |
Effect of insulin on glucose utilization in epitrochlearis muscle of rats with streptozocin-induced NIDDM.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 1990 |
Sustained release of insulin by double-layered implant using poly(D,L-lactic acid).
Topics: Animals; Blood Glucose; Body Weight; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experi | 1990 |
Role of beta-adrenergic mechanisms during exercise in poorly controlled diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Epinephrine; Fatty Acids, Nonesterifi | 1985 |
Characterization of new oral antidiabetic agent CS-045. Studies in KK and ob/ob mice and Zucker fatty rats.
Topics: Adipose Tissue; Animals; Benzopyrans; Blood Glucose; Chromans; Deoxyglucose; Diabetes Mellitus, Expe | 1988 |
Pathways of acetone's metabolism in the rat.
Topics: Acetone; Acetyl Coenzyme A; Animals; Diabetes Mellitus, Experimental; Diabetic Ketoacidosis; Female; | 1986 |
Mechanism of stimulation of liver glycogen synthesis by fructose in alloxan diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Fructose; Glucose-6-Phosphate; Glucosephosphates; Glycogen | 1986 |
Hepatic regeneration and metabolism after partial hepatectomy in diabetic rats: effects of insulin therapy.
Topics: Adenine Nucleotides; Animals; Diabetes Mellitus, Experimental; DNA; Glucose; Hepatectomy; Insulin; L | 1986 |
In vitro insulin action on erythrocyte glucose metabolism in normal and diabetic rats.
Topics: Animals; Blood Glucose; Carbon Dioxide; Diabetes Mellitus, Experimental; Erythrocytes; In Vitro Tech | 1988 |
Sensitive determination of D-lactic acid in biological samples by high-performance liquid chromatography.
Topics: Adult; Animals; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Humans; Hydra | 1988 |
Effect of hyperbaric oxygenation on normal and chronic streptozotocin diabetic peripheral nerves.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Biological Transport, Active; Diabetes Mellitus, | 1988 |
Intermediary metabolism in diabetic dogs treated with pancreatic autotransplants and insulin pumps.
Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Diabetes Mellitus, Experimental; Dogs; Fatty Acids, Noneste | 1986 |
The effects of lactate, acetate, glucose, insulin, starvation and alloxan-diabetes on protein synthesis in perfused rat hearts.
Topics: Acetates; Acetic Acid; Animals; Diabetes Mellitus, Experimental; Food; Glucose; Heart; Insulin; Lact | 1986 |
Glycogenolysis and lactogenesis in the ischemic diabetic rat heart.
Topics: Animals; Coronary Disease; Diabetes Mellitus, Experimental; Fasting; Glycogen; Lactates; Lactic Acid | 1987 |
Potential intercellular futile cycling of carbohydrates in diabetes.
Topics: Animals; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Extracellular Space; Female; Gala | 1987 |
Relationship between maternal and fetal fuels and placental glucose transfer in rats with maternal diabetes of varying severity.
Topics: 3-Hydroxybutyric Acid; Amino Acids; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; | 1985 |
Changes in the activity of 'active' pyruvate dehydrogenase complex in the newborn of normal and diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Dichloroacetic Acid; Enzyme Activation; Female; Glucose; I | 1985 |
Effects of fructose feeding on lipid parameters in obese and lean, diabetic and nondiabetic Zucker rats.
Topics: Animals; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dietary Carbo | 1985 |
Effect of glucose and insulin administration on hepatic adenylate energy charge and the cytosolic redox state in the neonates of normal and insulin-treated diabetic rats.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Animals, Newborn; Cytosol; Diabetes Mellitus, | 1985 |
Effects of alloxan-induced diabetes mellitus on the metabolism of the rat placenta.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alanine Transaminase; Animals; Aspartate Aminotransfe | 1986 |
Ischemic conduction failure and energy metabolism in experimental diabetic neuropathy.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Diabetes Mellitus, Experimental; Diabetic Neurop | 1985 |
Decreased uterine blood flow in the diabetic pregnant rat does not modify the augmented glucose transfer to the fetus.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Embryonic and Fetal Development; Female; Fe | 1985 |