lactic acid has been researched along with Allergic Encephalomyelitis in 17 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin has a beneficial role in adult rat models of multiple sclerosis (MS)." | 7.85 | Melatonin exacerbates acute experimental autoimmune encephalomyelitis by enhancing the serum levels of lactate: A potential biomarker of multiple sclerosis progression. ( Dokoohaki, S; Farhadi, N; Ghanbari, A; Ghareghani, M; Ghavamizadeh, M; Khodadoust, S; Parishani, M; Sadeghi, H; Zibara, K, 2017) |
| "Melatonin has a beneficial role in adult rat models of multiple sclerosis (MS)." | 3.85 | Melatonin exacerbates acute experimental autoimmune encephalomyelitis by enhancing the serum levels of lactate: A potential biomarker of multiple sclerosis progression. ( Dokoohaki, S; Farhadi, N; Ghanbari, A; Ghareghani, M; Ghavamizadeh, M; Khodadoust, S; Parishani, M; Sadeghi, H; Zibara, K, 2017) |
| "Additionally, demyelination regions of some MS patients had increased lactic acid content, suggesting the presence of ischemic events." | 1.40 | Early pathological alterations of lower lumbar cords detected by ultrahigh-field MRI in a mouse multiple sclerosis model. ( Arima, Y; Kamimura, D; Komai, Y; Mori, Y; Murakami, M; Nakatsuji, Y; Terayama, Y; Yoshioka, Y; Zhu, D, 2014) |
| " administration of Ac-PLP-BPI-NH(2)-2 microparticles can provide pharmacological efficacy and reduction in dosing frequency without increased toxicity." | 1.36 | Immune response to controlled release of immunomodulating peptides in a murine experimental autoimmune encephalomyelitis (EAE) model. ( Kiptoo, P; Siahaan, TJ; Topp, EM; Williams, TD; Zhao, H, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.76) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 12 (70.59) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Ghareghani, M | 3 |
| Farhadi, Z | 1 |
| Rivest, S | 1 |
| Zibara, K | 2 |
| Chao, CC | 1 |
| Gutiérrez-Vázquez, C | 1 |
| Rothhammer, V | 1 |
| Mayo, L | 1 |
| Wheeler, MA | 1 |
| Tjon, EC | 1 |
| Zandee, SEJ | 1 |
| Blain, M | 1 |
| de Lima, KA | 1 |
| Takenaka, MC | 1 |
| Avila-Pacheco, J | 1 |
| Hewson, P | 1 |
| Liu, L | 1 |
| Sanmarco, LM | 1 |
| Borucki, DM | 1 |
| Lipof, GZ | 1 |
| Trauger, SA | 1 |
| Clish, CB | 1 |
| Antel, JP | 1 |
| Prat, A | 1 |
| Quintana, FJ | 1 |
| de Toledo, JHDS | 1 |
| Fraga-Silva, TFC | 1 |
| Borim, PA | 1 |
| de Oliveira, LRC | 1 |
| Oliveira, EDS | 1 |
| Périco, LL | 1 |
| Hiruma-Lima, CA | 1 |
| de Souza, AAL | 1 |
| de Oliveira, CAF | 1 |
| Padilha, PM | 1 |
| Pinatto-Botelho, MF | 1 |
| Dos Santos, AA | 1 |
| Sartori, A | 1 |
| Zorzella-Pezavento, SFG | 1 |
| Cho, JJ | 1 |
| Stewart, JM | 2 |
| Drashansky, TT | 1 |
| Brusko, MA | 1 |
| Zuniga, AN | 1 |
| Lorentsen, KJ | 1 |
| Keselowsky, BG | 1 |
| Avram, D | 1 |
| Mori, Y | 1 |
| Murakami, M | 1 |
| Arima, Y | 1 |
| Zhu, D | 1 |
| Terayama, Y | 1 |
| Komai, Y | 1 |
| Nakatsuji, Y | 1 |
| Kamimura, D | 1 |
| Yoshioka, Y | 1 |
| Hunter, Z | 1 |
| McCarthy, DP | 1 |
| Yap, WT | 1 |
| Harp, CT | 1 |
| Getts, DR | 1 |
| Shea, LD | 1 |
| Miller, SD | 1 |
| Cappellano, G | 1 |
| Woldetsadik, AD | 1 |
| Orilieri, E | 1 |
| Shivakumar, Y | 1 |
| Rizzi, M | 1 |
| Carniato, F | 1 |
| Gigliotti, CL | 1 |
| Boggio, E | 1 |
| Clemente, N | 1 |
| Comi, C | 1 |
| Dianzani, C | 1 |
| Boldorini, R | 1 |
| Chiocchetti, A | 1 |
| Renò, F | 1 |
| Dianzani, U | 1 |
| Sestak, JO | 1 |
| Fakhari, A | 1 |
| Badawi, AH | 1 |
| Siahaan, TJ | 3 |
| Berkland, C | 2 |
| Maldonado, RA | 1 |
| LaMothe, RA | 1 |
| Ferrari, JD | 1 |
| Zhang, AH | 1 |
| Rossi, RJ | 1 |
| Kolte, PN | 1 |
| Griset, AP | 1 |
| O'Neil, C | 1 |
| Altreuter, DH | 1 |
| Browning, E | 1 |
| Johnston, L | 1 |
| Farokhzad, OC | 1 |
| Langer, R | 1 |
| Scott, DW | 1 |
| von Andrian, UH | 1 |
| Kishimoto, TK | 1 |
| Gammon, JM | 1 |
| Tostanoski, LH | 1 |
| Adapa, AR | 1 |
| Chiu, YC | 1 |
| Jewell, CM | 1 |
| Dokoohaki, S | 2 |
| Ghanbari, A | 2 |
| Farhadi, N | 2 |
| Khodadoust, S | 1 |
| Parishani, M | 1 |
| Ghavamizadeh, M | 1 |
| Sadeghi, H | 2 |
| Hosseini, SM | 1 |
| Mohammadi, R | 1 |
| Zhao, H | 1 |
| Kiptoo, P | 2 |
| Williams, TD | 1 |
| Topp, EM | 1 |
| Büyüktimkin, B | 1 |
| Wang, Q | 1 |
| Korn, T | 1 |
| Magnus, T | 1 |
| Jung, S | 1 |
| Simmons, RD | 1 |
| Bernard, CC | 1 |
| Kerlero de Rosbo, N | 1 |
| Carnegie, PR | 1 |
| Richards, TL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluating the Potential Role of Melatonin in Subjects With Relapsing Multiple Sclerosis (MS)[NCT03498131] | Early Phase 1 | 30 participants (Actual) | Interventional | 2018-05-09 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
17 other studies available for lactic acid and Allergic Encephalomyelitis
| Article | Year |
|---|---|
PDK4 Inhibition Ameliorates Melatonin Therapy by Modulating Cerebral Metabolism and Remyelination in an EAE Demyelinating Mouse Model of Multiple Sclerosis.
Topics: Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Lactic Acid; Melatonin | 2022 |
Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS.
Topics: 1-Deoxynojirimycin; Adaptor Proteins, Signal Transducing; Animals; Astrocytes; Brain; Cells, Culture | 2019 |
Organic Selenium Reaches the Central Nervous System and Downmodulates Local Inflammation: A Complementary Therapy for Multiple Sclerosis?
Topics: Animals; Anti-Inflammatory Agents; Central Nervous System; Disease Models, Animal; Encephalomyelitis | 2020 |
An antigen-specific semi-therapeutic treatment with local delivery of tolerogenic factors through a dual-sized microparticle system blocks experimental autoimmune encephalomyelitis.
Topics: Animals; Antigens; CD4-Positive T-Lymphocytes; Delayed-Action Preparations; Dendritic Cells; Drug De | 2017 |
Early pathological alterations of lower lumbar cords detected by ultrahigh-field MRI in a mouse multiple sclerosis model.
Topics: Angiography; Animals; Blood Vessels; Blood-Brain Barrier; Cell Movement; Demyelinating Diseases; Dis | 2014 |
A biodegradable nanoparticle platform for the induction of antigen-specific immune tolerance for treatment of autoimmune disease.
Topics: Animals; Antigens; Brain; Cytokines; Drug Carriers; Encephalomyelitis, Autoimmune, Experimental; Fem | 2014 |
Subcutaneous inverse vaccination with PLGA particles loaded with a MOG peptide and IL-10 decreases the severity of experimental autoimmune encephalomyelitis.
Topics: Animals; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Immune Tolerance; Interferon-g | 2014 |
Structure, size, and solubility of antigen arrays determines efficacy in experimental autoimmune encephalomyelitis.
Topics: Animals; Autoantigens; CD11a Antigen; Drug Carriers; Drug Compounding; Encephalomyelitis, Autoimmune | 2014 |
Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance.
Topics: Animals; Antigens; CD4-Positive T-Lymphocytes; Disease Models, Animal; Encephalomyelitis, Autoimmune | 2015 |
Controlled delivery of a metabolic modulator promotes regulatory T cells and restrains autoimmunity.
Topics: Animals; Antigen Presentation; Autoimmunity; Benzopyrans; Cell Proliferation; Coculture Techniques; | 2015 |
Melatonin exacerbates acute experimental autoimmune encephalomyelitis by enhancing the serum levels of lactate: A potential biomarker of multiple sclerosis progression.
Topics: Animals; Biomarkers; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Female; Lacti | 2017 |
Methylprednisolone improves lactate metabolism through reduction of elevated serum lactate in rat model of multiple sclerosis.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experiment | 2016 |
Immune response to controlled release of immunomodulating peptides in a murine experimental autoimmune encephalomyelitis (EAE) model.
Topics: Anaphylaxis; Animals; Body Weight; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carr | 2010 |
Vaccine-like controlled-release delivery of an immunomodulating peptide to treat experimental autoimmune encephalomyelitis.
Topics: Animals; Encephalomyelitis, Autoimmune, Experimental; Female; Immunologic Factors; Lactic Acid; Mice | 2012 |
Interaction with antigen-specific T cells regulates expression of the lactate transporter MCT1 in primary rat astrocytes: specific link between immunity and homeostasis.
Topics: Adoptive Transfer; Animals; Antibodies; Antigen-Presenting Cells; Antigens, CD; Astrocytes; Basigin; | 2005 |
Criteria for an adequate explanation of typical clinical signs of EAE in rodents.
Topics: Animals; Encephalomyelitis, Autoimmune, Experimental; Hindlimb; Lactates; Lactic Acid; Muscle Hypoto | 1984 |
Separation of lipids from lactate in experimental allergic encephalomyelitis by zero quantum NMR techniques.
Topics: Animals; Brain; Encephalomyelitis, Autoimmune, Experimental; Lactates; Lactic Acid; Lipid Metabolism | 1989 |