lactic acid has been researched along with Alexander Disease in 4 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Alexander Disease: Rare leukoencephalopathy with infantile-onset accumulation of Rosenthal fibers in the subpial, periventricular, and subependymal zones of the brain. Rosenthal fibers are GLIAL FIBRILLARY ACIDIC PROTEIN aggregates found in ASTROCYTES. Juvenile- and adult-onset types show progressive atrophy of the lower brainstem instead. De novo mutations in the GFAP gene are associated with the disease with propensity for paternal inheritance.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Strongly elevated concentrations of myo-inositol in conjunction with normal or increased choline-containing compounds in all regions investigated point to astrocytosis and demyelination." | 3.72 | Cerebral proton magnetic resonance spectroscopy in infantile Alexander disease. ( Brockmann, K; Dechent, P; Frahm, J; Hanefeld, F; Haupt, M; Meins, M; Sperner, J; Stephani, U, 2003) |
| "Alexander disease is a neurodegenerative disorder characterized by macrocephaly and progressive demyelination with frontal lobe preponderance." | 1.33 | Early mitochondrial dysfunction in an infant with Alexander disease. ( Cáceres-Marzal, C; Fernández, S; Galán, E; Vaquerizo, J, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brockmann, K | 1 |
| Dechent, P | 1 |
| Meins, M | 1 |
| Haupt, M | 1 |
| Sperner, J | 1 |
| Stephani, U | 1 |
| Frahm, J | 1 |
| Hanefeld, F | 1 |
| Bassuk, AG | 1 |
| Joshi, A | 1 |
| Burton, BK | 1 |
| Larsen, MB | 1 |
| Burrowes, DM | 1 |
| Stack, C | 1 |
| Cáceres-Marzal, C | 1 |
| Vaquerizo, J | 1 |
| Galán, E | 1 |
| Fernández, S | 1 |
| Bizzi, A | 1 |
| Castelli, G | 1 |
| Bugiani, M | 1 |
| Barker, PB | 1 |
| Herskovits, EH | 1 |
| Danesi, U | 1 |
| Erbetta, A | 1 |
| Moroni, I | 1 |
| Farina, L | 1 |
| Uziel, G | 1 |
4 other studies available for lactic acid and Alexander Disease
| Article | Year |
|---|---|
Cerebral proton magnetic resonance spectroscopy in infantile Alexander disease.
Topics: Alexander Disease; Aspartic Acid; Brain; Child; Child, Preschool; Demyelinating Diseases; Disease Pr | 2003 |
Alexander disease with serial MRS and a new mutation in the glial fibrillary acidic protein gene.
Topics: Acidosis, Respiratory; Alexander Disease; Basal Ganglia; Choline; Creatine; Disease Progression; DNA | 2003 |
Early mitochondrial dysfunction in an infant with Alexander disease.
Topics: Alexander Disease; Biopsy; Brain; Cytochrome-c Oxidase Deficiency; Diagnosis, Differential; Female; | 2006 |
Classification of childhood white matter disorders using proton MR spectroscopic imaging.
Topics: Adrenoleukodystrophy; Adult; Alexander Disease; Aspartic Acid; Brain; Child; Child, Preschool; Choli | 2008 |