lactic acid has been researched along with Alcoholism in 35 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lactic acidosis is common in critical care; by contrast, a subtype called alcohol-associated lactic acidosis (AALA) is rarely encountered." | 7.83 | Prognosis of alcohol-associated lactic acidosis in critically ill patients: an 8-year study. ( Chan, KS; Tseng, KL; Weng, SF; Yang, CC, 2016) |
| " Initial investigations demonstrated a severe lactic acidosis." | 7.72 | Severe lactic acidosis following alcohol related generalised seizures. ( Hulme, J; Sherwood, N, 2004) |
| "Lactic acidosis is common in critical care; by contrast, a subtype called alcohol-associated lactic acidosis (AALA) is rarely encountered." | 3.83 | Prognosis of alcohol-associated lactic acidosis in critically ill patients: an 8-year study. ( Chan, KS; Tseng, KL; Weng, SF; Yang, CC, 2016) |
| " Initial investigations demonstrated a severe lactic acidosis." | 3.72 | Severe lactic acidosis following alcohol related generalised seizures. ( Hulme, J; Sherwood, N, 2004) |
| " The authors present three patients with alcoholism in whom diagnosis of panic was facilitated by intravenous lactate infusion, and whose symptoms were alleviated by clonazepam." | 3.68 | The diagnosis and treatment of panic disorder in alcoholics: three cases. ( Baron, DH; Ciraulo, DA; Sands, BF; Shader, RI, 1990) |
| "Alcohol dependence is a common disorder associated with significant morbidity and mortality." | 2.71 | Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial. ( Ehrich, EW; Garbutt, JC; Gastfriend, DR; Kranzler, HR; Loewy, JW; O'Malley, SS; Pettinati, HM; Silverman, BL, 2005) |
| "Alcoholic ketoacidosis (AKA) is a complex syndrome that results from disrupted metabolism in the setting of excessive alcohol use and poor oral intake." | 1.43 | A Patient With Alcoholic Ketoacidosis and Profound Lactemia. ( Gerrity, RS; Katz, KD; King, AM; Menke, NB; Pizon, AF, 2016) |
| "Diabetes and alcohol abuse may cause severe metabolic disturbances that can be fatal." | 1.39 | Assessment of Traub formula and ketone bodies in cause of death investigations. ( Keltanen, T; Lindroos, K; Palo, JU; Partanen, T; Sajantila, A; Valonen, T, 2013) |
| "Alcohol ketoacidosis is a frequently missed diagnosis, but is well described in the literature." | 1.39 | Ketoacidosis and trace amounts of isopropanol in a chronic alcoholic patient. ( Dwyer, JB; Tamama, K, 2013) |
| "Diabetic ketoacidosis (DKA) and alcoholic ketoacidosis (AKA) are two medical emergencies characterized by elevated total ketone body concentration." | 1.31 | Differences in metabolic and hormonal milieu in diabetic- and alcohol-induced ketoacidosis. ( Bhoola, SM; DiGirolamo, M; Isaacs, SD; Kokko, JP; Tuvlin, JA; Umpierrez, GE, 2000) |
| " Male Sprague-Dawley rats were rendered physically dependent on ethanol by intragastric administration of ethanol at a dosage of 9 to 15 grams per kilogram per day over a 4-day period." | 1.27 | Suppression of an ethanol withdrawal syndrome in rats by butyrate, lactate and beta-hydroxybutyrate. ( Derr, M; Derr, RF; Draves, K, 1983) |
| "Metabolic acidosis is due to lactic acidosis, ketoacidosis and acetic acidosis but the degree of each varies from patient to patient." | 1.27 | Metabolic acidosis in the alcoholic: a pathophysiologic approach. ( Halperin, ML; Hammeke, M; Josse, RG; Jungas, RL, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (34.29) | 18.7374 |
| 1990's | 5 (14.29) | 18.2507 |
| 2000's | 8 (22.86) | 29.6817 |
| 2010's | 9 (25.71) | 24.3611 |
| 2020's | 1 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Yoshida, H | 1 |
| Harada, K | 1 |
| Sakamoto, Y | 1 |
| Yoshimura, J | 1 |
| Shimazu, T | 1 |
| Matsumoto, H | 1 |
| Kettritz, R | 1 |
| Ritter, T | 1 |
| Rudolph, B | 1 |
| Luft, FC | 1 |
| Jiawan, A | 1 |
| Tandjung, K | 1 |
| Pagar, KP | 1 |
| Vavia, PR | 1 |
| Keltanen, T | 1 |
| Sajantila, A | 1 |
| Palo, JU | 1 |
| Partanen, T | 1 |
| Valonen, T | 1 |
| Lindroos, K | 1 |
| Gerrity, RS | 1 |
| Pizon, AF | 1 |
| King, AM | 1 |
| Katz, KD | 1 |
| Menke, NB | 1 |
| Yang, CC | 1 |
| Chan, KS | 1 |
| Tseng, KL | 1 |
| Weng, SF | 1 |
| Akala, EO | 1 |
| Wiriyacoonkasem, P | 1 |
| Pan, G | 1 |
| Maturu, P | 1 |
| Varadacharyulu, N | 1 |
| Dwyer, JB | 1 |
| Tamama, K | 1 |
| LINDE, S | 1 |
| Hulme, J | 1 |
| Sherwood, N | 1 |
| Lang, W | 1 |
| Garbutt, JC | 1 |
| Kranzler, HR | 1 |
| O'Malley, SS | 1 |
| Gastfriend, DR | 1 |
| Pettinati, HM | 1 |
| Silverman, BL | 1 |
| Loewy, JW | 1 |
| Ehrich, EW | 1 |
| Siegel, S | 1 |
| Pavlic, M | 1 |
| Libiseller, K | 1 |
| Hermann, M | 1 |
| Hengster, P | 1 |
| Margreiter, R | 1 |
| Wurm, M | 1 |
| Coiro, V | 1 |
| Casti, A | 1 |
| Jotti, GS | 1 |
| Rubino, P | 1 |
| Manfredi, G | 1 |
| Maffei, ML | 1 |
| Melani, A | 1 |
| Volta, E | 1 |
| Chiodera, P | 1 |
| Lieber, CS | 2 |
| Nuutinen, HU | 1 |
| Salaspuro, MP | 1 |
| Valle, M | 1 |
| Lindros, KO | 1 |
| Hoberg, B | 1 |
| Delank, HW | 1 |
| Derr, RF | 1 |
| Draves, K | 1 |
| Derr, M | 1 |
| Baraona, E | 1 |
| Jauhonen, P | 1 |
| Miyakawa, H | 1 |
| Halperin, ML | 1 |
| Hammeke, M | 1 |
| Josse, RG | 1 |
| Jungas, RL | 1 |
| Palmer, KR | 1 |
| Jenkins, WJ | 1 |
| McDonough, KH | 1 |
| Causey, KM | 1 |
| Wassif, WS | 1 |
| Sherman, D | 1 |
| Salisbury, JR | 1 |
| Peters, TJ | 1 |
| George, DT | 3 |
| Lindquist, T | 1 |
| Ragan, PW | 2 |
| Alim, T | 1 |
| Eckardt, MJ | 1 |
| Linnoila, M | 2 |
| Hibbeln, JR | 1 |
| Umhau, JC | 1 |
| Phillips, MJ | 1 |
| Doty, L | 1 |
| Hommer, D | 1 |
| Rawlings, RR | 1 |
| Umpierrez, GE | 1 |
| DiGirolamo, M | 1 |
| Tuvlin, JA | 1 |
| Isaacs, SD | 1 |
| Bhoola, SM | 1 |
| Kokko, JP | 1 |
| Johnson, RD | 1 |
| Bahnisch, J | 1 |
| Stewart, B | 1 |
| Shearman, DJ | 1 |
| Edwards, JB | 1 |
| Baron, DH | 1 |
| Sands, BF | 1 |
| Ciraulo, DA | 1 |
| Shader, RI | 1 |
| Nutt, DJ | 1 |
| Waxman, RP | 1 |
| Cowley, DS | 1 |
| Jensen, CF | 1 |
| Johannessen, D | 1 |
| Parker, L | 1 |
| Dager, SR | 1 |
| Walker, RD | 1 |
| Nuzhnyĭ, VP | 1 |
| Tezikov, EB | 1 |
| Savitskaia, EV | 1 |
| Ugriumov, AI | 1 |
| Teschke, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Bridging ED to Outpatient AUD Therapy With Naltrexone[NCT05228418] | Phase 4 | 20 participants (Anticipated) | Interventional | 2022-03-31 | Not yet recruiting | ||
| In Hospital Administration of Extended-Release Naltrexone for Alcohol Use Disorder: A Pilot Study of Feasibility and Acceptability[NCT05087771] | Phase 4 | 0 participants (Actual) | Interventional | 2022-03-31 | Withdrawn (stopped due to no longer randomized, drug being offered to all patients) | ||
| A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Medisorb® Naltrexone in Alcohol-Dependent Adults[NCT01218958] | Phase 3 | 624 participants (Actual) | Interventional | 2002-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
A TEAE is any adverse event, whether or not considered drug-related, that develops or worsens in severity after study drug administration begins (ie, from the first administration through the end of the follow-up period). (NCT01218958)
Timeframe: 24 weeks (Baseline to Week 24)
| Intervention | Participants (Number) |
|---|---|
| Medisorb Naltrexone 190 mg | 190 |
| Medisorb Naltrexone 380 mg | 187 |
| Placebo Groups (Pooled) | 181 |
Drinking rates were assessed from participants' self-reports using the validated Timeline Follow-Back (TLFB) method. Using a TLFB calendar, participants reported the number of days they had consumed alcohol along with the amount they consumed on each day. A heavy drinking day was defined as ≥5 drinks/day for men and ≥4 drinks/day for women. (NCT01218958)
Timeframe: Baseline through Week 24 (168 days)
| Intervention | Percentage of days (Median) |
|---|---|
| Medisorb Naltrexone 190 mg | 14.75 |
| Medisorb Naltrexone 380 mg | 10.23 |
| Placebo Groups (Pooled) | 19.77 |
4 trials available for lactic acid and Alcoholism
| Article | Year |
|---|---|
Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial.
Topics: Adult; Alcoholism; Double-Blind Method; Drug Carriers; Female; Humans; Injections, Intramuscular; La | 2005 |
Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial.
Topics: Adult; Alcoholism; Double-Blind Method; Drug Carriers; Female; Humans; Injections, Intramuscular; La | 2005 |
Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial.
Topics: Adult; Alcoholism; Double-Blind Method; Drug Carriers; Female; Humans; Injections, Intramuscular; La | 2005 |
Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial.
Topics: Adult; Alcoholism; Double-Blind Method; Drug Carriers; Female; Humans; Injections, Intramuscular; La | 2005 |
Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial.
Topics: Adult; Alcoholism; Double-Blind Method; Drug Carriers; Female; Humans; Injections, Intramuscular; La | 2005 |
Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial.
Topics: Adult; Alcoholism; Double-Blind Method; Drug Carriers; Female; Humans; Injections, Intramuscular; La | 2005 |
Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial.
Topics: Adult; Alcoholism; Double-Blind Method; Drug Carriers; Female; Humans; Injections, Intramuscular; La | 2005 |
Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial.
Topics: Adult; Alcoholism; Double-Blind Method; Drug Carriers; Female; Humans; Injections, Intramuscular; La | 2005 |
Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial.
Topics: Adult; Alcoholism; Double-Blind Method; Drug Carriers; Female; Humans; Injections, Intramuscular; La | 2005 |
Use of dynamic tests of muscle function and histomorphometry of quadriceps muscle biopsies in the investigation of patients with chronic alcohol misuse and chronic fatigue syndrome.
Topics: Adult; Alcoholism; Ammonia; AMP Deaminase; Analysis of Variance; Biopsy, Needle; Creatine Kinase; Di | 1994 |
Effect of alcoholism on the incidence of lactate-induced panic attacks.
Topics: Adult; Alcoholism; Female; Hemodynamics; Hormones; Humans; Lactic Acid; Male; Panic Disorder; Psychi | 1997 |
Lactate-induced rage and panic in a select group of subjects who perpetrate acts of domestic violence.
Topics: Adult; Alcoholism; Blood Pressure; Domestic Violence; Double-Blind Method; Female; Heart Rate; Human | 2000 |
31 other studies available for lactic acid and Alcoholism
| Article | Year |
|---|---|
Comparison of Quantitative Values of Headspace Gas Chromatography--Mass Spectrometry and a Formate Quantification Kit in Blood Formate Quantification.
Topics: Alcoholism; Formates; Gas Chromatography-Mass Spectrometry; Humans; Lactic Acid; Methanol | 2023 |
The Case | Acid-base diagnoses in the 21st century.
Topics: Acidosis; Acute Kidney Injury; Alcoholic Intoxication; Alcoholism; Antidotes; Creatinine; Ethylene G | 2017 |
New-Onset Heart Failure.
Topics: Acidosis; Adult; Alcoholism; Beriberi; Dyspnea; Echocardiography; Edema; Electrocardiography; Heart | 2019 |
Naltrexone-loaded poly[La-(Glc-Leu)] polymeric microspheres for the treatment of alcohol dependence: in vitro characterization and in vivo biocompatibility assessment.
Topics: Alcoholism; Animals; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Drug Del | 2014 |
Assessment of Traub formula and ketone bodies in cause of death investigations.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Alcoholism; Algorithms; Autopsy; Biomarkers; Blood Gl | 2013 |
A Patient With Alcoholic Ketoacidosis and Profound Lactemia.
Topics: Acid-Base Equilibrium; Alcoholism; Fluid Therapy; Glucose; Humans; Hyperlactatemia; Ketosis; Lactic | 2016 |
Prognosis of alcohol-associated lactic acidosis in critically ill patients: an 8-year study.
Topics: Acidosis, Lactic; Adult; Aged; Alcoholism; Critical Care; Critical Illness; Female; Hospital Mortali | 2016 |
Studies on in vitro availability, degradation, and thermal properties of naltrexone-loaded biodegradable microspheres.
Topics: Alcoholism; Chromatography, Gel; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; | 2011 |
Adaptive changes in fatty acid profile of erythrocyte membrane in relation to plasma and red cell metabolic changes in chronic alcoholic men.
Topics: Adult; Alcoholism; Amino Acids; Blood Glucose; Case-Control Studies; Erythrocyte Membrane; Erythrocy | 2012 |
Ketoacidosis and trace amounts of isopropanol in a chronic alcoholic patient.
Topics: 2-Propanol; 3-Hydroxybutyric Acid; Acetone; Adult; Alcoholism; Blood Glucose; Chronic Disease; Human | 2013 |
[Enzymatic activity (glutamic oxalacetic transaminase, glutamic pyruvic transaminase & lactic acid dehydrogenase, in alcoholism].
Topics: Alanine Transaminase; Alcoholic Intoxication; Alcoholism; L-Lactate Dehydrogenase; Lactic Acid; Oxid | 1959 |
Severe lactic acidosis following alcohol related generalised seizures.
Topics: Acidosis, Lactic; Alcoholism; Epilepsy, Tonic-Clonic; Humans; Lactic Acid; Male; Middle Aged | 2004 |
A response to 'Severe lactic acidosis following alcohol related generalised seizures'.
Topics: Acidosis, Lactic; Alcoholism; Epilepsy, Tonic-Clonic; Humans; Lactic Acid | 2005 |
Extended-release intramuscular naltrexone: a viewpoint by Steven Siegel.
Topics: Alcoholism; Delayed-Action Preparations; Humans; Injections, Intramuscular; Lactic Acid; Microsphere | 2006 |
Small human hepatocytes in rotary culture for treatment of alcohol addicts? A pilot study.
Topics: Alcoholism; Cell Count; Cell Culture Techniques; Cell Line; Culture Media; Cytochrome P-450 Enzyme S | 2007 |
Adrenocorticotropic hormone/cortisol response to physical exercise in abstinent alcoholic patients.
Topics: Adrenocorticotropic Hormone; Adult; Alcoholism; Blood Glucose; Carbon Dioxide; Exercise; Fatty Acids | 2007 |
Alcohol and the liver. Recent developments in preclinical and clinical research. Overview.
Topics: Adenosine Triphosphatases; Alcohol Dehydrogenase; Alcohol Oxidoreductases; Alcoholism; Animals; Etha | 1984 |
Blood acetaldehyde concentration gradient between hepatic and antecubital venous blood in ethanol-intoxicated alcoholics and controls.
Topics: Acetaldehyde; Adult; Alcoholic Intoxication; Alcoholism; Ethanol; Humans; Kinetics; Lactates; Lactic | 1984 |
[Cerebrospinal fluid findings in brain atrophies detected by computer tomography].
Topics: Alcoholism; Atrophy; Brain; Brain Damage, Chronic; Brain Ischemia; Cerebrospinal Fluid Proteins; Enc | 1984 |
Suppression of an ethanol withdrawal syndrome in rats by butyrate, lactate and beta-hydroxybutyrate.
Topics: 3-Hydroxybutyric Acid; Alcoholism; Animals; Butyrates; Butyric Acid; Citric Acid Cycle; Humans; Hydr | 1983 |
Zonal redox changes as a cause of selective perivenular hepatotoxicity of alcohol.
Topics: Alcoholism; Animals; Ethanol; Fatty Liver, Alcoholic; Hepatic Veins; Humans; Lactates; Lactic Acid; | 1983 |
Metabolic acidosis in the alcoholic: a pathophysiologic approach.
Topics: Acetates; Acid-Base Equilibrium; Acidosis; Adenosine Triphosphate; Alcoholism; Ethanol; Glucose; Hum | 1983 |
Impaired acetaldehyde oxidation in alcoholics.
Topics: Acetaldehyde; Adult; Alcoholism; Aldehyde Oxidoreductases; Ethanol; Humans; Lactates; Lactic Acid; L | 1982 |
Effects of sepsis on recovery of the heart from 50 min ischemia.
Topics: Adenosine Triphosphate; Alcoholism; Animals; Catalase; Escherichia coli; Lactates; Lactic Acid; Male | 1994 |
Differences in metabolic and hormonal milieu in diabetic- and alcohol-induced ketoacidosis.
Topics: Adult; Alcoholism; Blood Glucose; Diabetic Ketoacidosis; Diagnosis, Differential; Epinephrine; Femal | 2000 |
Optimized spectrophotometric determination of aldehyde dehydrogenase activity in erythrocytes.
Topics: Acetaldehyde; Alcoholism; Aldehyde Dehydrogenase; Aldehydes; Drug Stability; Erythrocytes; Humans; K | 1992 |
The diagnosis and treatment of panic disorder in alcoholics: three cases.
Topics: Adult; Alcohol Drinking; Alcoholism; Anxiety Disorders; Clonazepam; Diazepam; Follow-Up Studies; Hum | 1990 |
Panic response to lactate administration in alcoholic and nonalcoholic patients with panic disorder.
Topics: Adult; Alcoholism; Anxiety Disorders; Blood Glucose; Blood Pressure; Calcium; Chlorides; Fear; Femal | 1989 |
Response to sodium lactate infusion in alcoholics with panic attacks.
Topics: Adult; Alcoholism; Anxiety Disorders; Fear; Heart Rate; Humans; Lactates; Lactic Acid; Male; Middle | 1989 |
[Contractile function, glucose consumption and lactate release by the isolated rat heart during different regimens of alcohol administration and after discontinuation of ethanol].
Topics: Alcoholic Intoxication; Alcoholism; Animals; Ethanol; Glucose; Glycogen; Lactates; Lactic Acid; Myoc | 1986 |
[Alcohol and metabolism].
Topics: Acetaldehyde; Alcohol Drinking; Alcoholism; Amino Acids; Blood Glucose; Cholesterol; Energy Metaboli | 1985 |