lactic acid and Agoraphobia studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Research Excerpts

Excerpt	Relevance	Reference
"An open clinical trial of alprazolam therapy of patients with panic disorder or agoraphobia with panic attacks was undertaken to clarify certain issues not resolved by previous studies."	5.06	Alprazolam in the treatment of panic disorders. ( Campeas, R; Davies, SR; Fyer, AJ; Goetz, D; Gorman, JM; Klein, DF; Levin, A; Liebowitz, MR, 1986)
" Many double-blind controlled studies have shown that imipramine effectively ameliorates panic attacks and agoraphobia."	4.77	Panic disorder: response to sodium lactate and treatment with antidepressants. ( Rifkin, A; Siris, SG, 1985)
"The diazepam pretreatment condition was associated with a significantly increased infusion duration and a significant attenuation of rate of API symptom increase in response to lactate."	2.68	Effects of intravenous diazepam pretreatment on lactate-induced panic. ( Campeas, RB; Coplan, JD; Davies, SO; Dillon, DJ; Fyer, AJ; Gorman, JM; Klein, DF; Liebowitz, MR; Martinez, J, 1995)
"Naloxone did not produce panic attacks or alter responses to lactate."	1.27	Effects of naloxone on patients with panic attacks. ( Dillon, DJ; Fyer, AJ; Gorman, JM; Klein, DF; Liebowitz, MR, 1984)
"The association with mitral valve prolapse suggests that perhaps 38 per cent of patients presenting with symptoms of panic disorders have mitral valve prolapse on echocardiography."	1.27	The genetics of panic disorder and agoraphobia. ( Crowe, RR, 1985)

Timeframe	Studies, this research(%)	All Research%
pre-1990	31 (83.78)	18.7374
1990's	6 (16.22)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Liebowitz, MR	17
Gorman, JM	18
Fyer, AJ	14
Dillon, DJ	5
Klein, DF	16
Levy, GF	1
McGrath, P	1
Appleby, IL	3
Davies, SO	5
Pohl, R	4
Rainey, JM	2
Gershon, S	1
Levitt, M	4
Danielson, E	1
Martinez, J	2
Dillon, D	6
Levy, G	2
Anderson, S	2
Palij, M	2
Balon, R	3
Yeragani, VK	3
Merlos, B	1
Sherwood, P	1
Coplan, JD	1
Campeas, RB	1
van Megen, HJ	1
Westenberg, HG	1
den Boer, JA	1
Goetz, RR	3
Davies, S	2
Dager, SR	4
Cowley, DS	5
Dorsa, DM	1
Dunner, DL	5
Aronson, TA	2
Carasiti, I	1
McBane, D	1
Whitaker-Azmitia, P	2
Roy-Byrne, PP	1
Schmidt, P	1
Cannon, RO	1
Diem, H	1
Rubinow, DR	1
Hollander, E	3
Cohen, B	2
Papp, LA	2
Crowe, RR	1
Campeas, R	1
Levin, A	1
Davies, SR	1
Goetz, D	1
Carr, DB	1
Sheehan, DV	1
Surman, OS	1
Coleman, JH	1
Greenblatt, DJ	1
Heninger, GR	1
Jones, KJ	1
Levine, PH	1
Watkins, WD	1
Fyer, A	2
Caraseti, I	1
Levin, AP	1
Doran, AR	1
Paul, SM	1
Friedman, S	1
Sunderland, GS	1
Rosenblum, LA	1
Cohen, BS	2
Ortiz, A	1
Weinberg, P	1
Koenigsberg, HW	1
Pollak, C	1
Sullivan, T	1
Hyde, TS	1
Ehlers, A	1
Margraf, J	1
Roth, WT	1
Taylor, CB	1
Maddock, RJ	1
Sheikh, J	1
Kopell, ML	1
McClenahan, KL	1
Gossard, D	1
Blowers, GH	1
Rifkin, A	1
Siris, SG	1
Stein, JM	1

Article	Year
Changes in the drug treatment of anxiety disorders. Psychopathology, 1984, Volume: 17 Suppl 1 Topics: Agoraphobia; Antidepressive Agents; Anxiety Disorders; Clinical Trials as Topic; Depressive Disorder	1984
Panic disorder: response to sodium lactate and treatment with antidepressants. Progress in neuro-psychopharmacology & biological psychiatry, 1985, Volume: 9, Issue:1 Topics: Agoraphobia; Anxiety Disorders; Depressive Disorder; Double-Blind Method; Fear; Humans; Imipramine;	1985

Article	Year
Changes in the drug treatment of anxiety disorders. Psychopathology, 1984, Volume: 17 Suppl 1 Topics: Agoraphobia; Antidepressive Agents; Anxiety Disorders; Clinical Trials as Topic; Depressive Disorder	1984
Changes in appetite and weight during the pharmacological treatment of patients with panic disorder. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1993, Volume: 38, Issue:1 Topics: Adult; Agoraphobia; Appetite; Body Weight; Diazepam; Dietary Carbohydrates; Double-Blind Method; Fem	1993
Effects of intravenous diazepam pretreatment on lactate-induced panic. Psychiatry research, 1995, Sep-29, Volume: 58, Issue:2 Topics: Adult; Agoraphobia; Anti-Anxiety Agents; Arousal; Blood Pressure; Diazepam; Fear; Female; Heart Rate	1995
Effect of the cholecystokinin-B receptor antagonist L-365,260 on lactate-induced panic attacks in panic disorder patients. Biological psychiatry, 1996, Oct-15, Volume: 40, Issue:8 Topics: Adult; Agoraphobia; Arousal; Benzodiazepinones; Double-Blind Method; Female; Humans; Lactic Acid; Ma	1996
Microvascular angina and panic disorder. International journal of psychiatry in medicine, 1989, Volume: 19, Issue:4 Topics: Agoraphobia; Angina Pectoris, Variant; Anxiety Disorders; Arousal; Coronary Angiography; Coronary Va	1989
Alprazolam in the treatment of panic disorders. Journal of clinical psychopharmacology, 1986, Volume: 6, Issue:1 Topics: Adult; Agoraphobia; Alprazolam; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Clinical Tr	1986
Neuroendocrine correlates of lactate-induced anxiety and their response to chronic alprazolam therapy. The American journal of psychiatry, 1986, Volume: 143, Issue:4 Topics: Adolescent; Adult; Agoraphobia; Alprazolam; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines;	1986
Lactate infusions and panic attacks: do patients and controls respond differently? Psychiatry research, 1986, Volume: 17, Issue:4 Topics: Adult; Affective Symptoms; Agoraphobia; Anxiety; Anxiety Disorders; Blood Pressure; Fear; Female; He	1986
Lactate vulnerability of remitted panic patients. Psychiatry research, 1985, Volume: 14, Issue:2 Topics: Adult; Agoraphobia; Antidepressive Agents, Tricyclic; Anxiety Disorders; Clinical Trials as Topic; D	1985

Article	Year
Effects of naloxone on patients with panic attacks. The American journal of psychiatry, 1984, Volume: 141, Issue:8 Topics: Adult; Agoraphobia; Anxiety Disorders; Endorphins; Fear; Female; Humans; Infusions, Parenteral; Lact	1984
Effect of acute beta-adrenergic blockade on lactate-induced panic. Archives of general psychiatry, 1983, Volume: 40, Issue:10 Topics: Adult; Agoraphobia; Blood Pressure; Fear; Female; Heart Rate; Humans; Lactates; Lactic Acid; Male; M	1983
Sodium lactate infusion, panic attacks, and ionized calcium. Biological psychiatry, 1984, Volume: 19, Issue:10 Topics: Agoraphobia; Anxiety Disorders; Calcium; Fear; Humans; Infusions, Parenteral; Lactates; Lactic Acid;	1984
Lactate provocation of panic attacks. I. Clinical and behavioral findings. Archives of general psychiatry, 1984, Volume: 41, Issue:8 Topics: Adult; Agoraphobia; Anxiety Disorders; Clonidine; Desipramine; Fear; Female; Humans; Imipramine; Lac	1984
Consistencies between recalled panic and lactate-induced panic. Anxiety, 1994, Volume: 1, Issue:1 Topics: Adolescent; Adult; Agoraphobia; Arousal; Diagnosis, Differential; Female; Humans; Infusions, Intrave	1994
Sodium D-lactate infusion of panic disorder patients. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1990, Volume: 3, Issue:3 Topics: Adult; Agoraphobia; Bicarbonates; Blood Pressure; Calcium; Carbon Dioxide; Fear; Female; Heart Rate;	1990
Lactate-induced panic and beta-adrenergic blockade. Psychiatry research, 1990, Volume: 32, Issue:1 Topics: Adult; Agoraphobia; Arousal; Dose-Response Relationship, Drug; Fear; Female; Heart Rate; Humans; Inf	1990
Plasma beta-endorphin response to lactate infusion. Biological psychiatry, 1989, Jan-15, Volume: 25, Issue:2 Topics: Adult; Agoraphobia; beta-Endorphin; Depressive Disorder; Fear; Female; Humans; Infusions, Intravenou	1989
Biological correlates of lactate sensitivity in panic disorder. Biological psychiatry, 1989, Volume: 26, Issue:5 Topics: Adult; Agoraphobia; Arousal; Dihydroalprenolol; Fear; Female; Heart Rate; Humans; Hydrocortisone; La	1989
Prolactin and sodium lactate-induced panic. Psychiatry research, 1989, Volume: 28, Issue:2 Topics: Adult; Agoraphobia; Arousal; Blood Pressure; Fear; Female; Heart Rate; Humans; Infusions, Intravenou	1989
Do panic disorder patients indiscriminately endorse somatic complaints? Psychiatry research, 1989, Volume: 29, Issue:2 Topics: Adult; Agoraphobia; Arousal; Fear; Female; Humans; Infusions, Intravenous; Lactates; Lactic Acid; Ma	1989
The genetics of panic disorder and agoraphobia. Psychiatric developments, 1985,Summer, Volume: 3, Issue:2 Topics: Adolescent; Adoption; Adult; Agoraphobia; Anxiety Disorders; Brain; Diseases in Twins; Fear; Genetic	1985
Biological markers in panic states: lactate-induced panic and mitral valve prolapse. Biological psychiatry, 1987, Volume: 22, Issue:3 Topics: Adolescent; Adult; Aged; Agoraphobia; Alprazolam; Anti-Anxiety Agents; Anxiety Disorders; Creatinine	1987
Cortisol and sodium lactate-induced panic. Archives of general psychiatry, 1989, Volume: 46, Issue:2 Topics: Adult; Agoraphobia; Anxiety Disorders; Fear; Female; Humans; Hydrocortisone; Infusions, Intravenous;	1989
Differential reactivity to lactate infusions: the relative role of biological, psychological, and conditioning variables. Biological psychiatry, 1989, Feb-15, Volume: 25, Issue:4 Topics: Adult; Agoraphobia; Arousal; Conditioning, Psychological; Fear; Female; Humans; Infusions, Intraveno	1989
Pituitary adrenocortical unresponsiveness in lactate-induced panic. Psychiatry research, 1987, Volume: 21, Issue:1 Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Agoraphobia; Fear; Female; Humans; Hydrocortisone; L	1987
Response to sodium lactate in panic disorder: relationship to presenting clinical variables. Psychiatry research, 1988, Volume: 25, Issue:3 Topics: Adult; Agoraphobia; Arousal; Fear; Female; Humans; Lactates; Lactic Acid; Male; Middle Aged; Panic;	1988
A nonhuman primate model of panic disorder. Psychiatry research, 1988, Volume: 23, Issue:1 Topics: Agoraphobia; Animals; Arousal; Disease Models, Animal; Fear; Female; Lactates; Lactic Acid; Macaca;	1988
Antipanic drug effects during lactate infusion in lactate-refractory panic patients. Psychiatry research, 1987, Volume: 21, Issue:3 Topics: Adult; Agoraphobia; Alprazolam; Clonidine; Desipramine; Fear; Female; Fluoxetine; Humans; Imipramine	1987
Measurement of lactate-induced panic and anxiety. Psychiatry research, 1987, Volume: 20, Issue:2 Topics: Adult; Agoraphobia; Anxiety Disorders; Fear; Female; Humans; Lactates; Lactic Acid; Male; Panic; Psy	1987
Do higher preinfusion heart rates predict laboratory-induced panic attacks? Biological psychiatry, 1987, Volume: 22, Issue:5 Topics: Adolescent; Adult; Agoraphobia; Double-Blind Method; Fear; Female; Heart Rate; Humans; Infusions, Pa	1987
The sleep lactate infusion: arousal and the panic mechanism. Biological psychiatry, 1987, Volume: 22, Issue:6 Topics: Adolescent; Adult; Agoraphobia; Anxiety Disorders; Arousal; Fear; Female; Humans; Lactates; Lactic A	1987
Lactate infusions: the role of baseline anxiety. Psychiatry research, 1987, Volume: 21, Issue:2 Topics: Adult; Agoraphobia; Anxiety Disorders; Blood Pressure; Diastole; Fear; Female; Heart Rate; Humans; L	1987
Possible mechanisms for lactate's induction of panic. The American journal of psychiatry, 1986, Volume: 143, Issue:4 Topics: Agoraphobia; Alkalosis; Anxiety Disorders; Blood Pressure; Calcium; Epinephrine; Fear; Female; Heart	1986
Lactate-induced panic in primary affective disorder. The American journal of psychiatry, 1986, Volume: 143, Issue:5 Topics: Adult; Agoraphobia; Anxiety Disorders; Depressive Disorder; Diagnosis, Differential; Fear; Female; H	1986
Lactate provocation of panic attacks. II. Biochemical and physiological findings. Archives of general psychiatry, 1985, Volume: 42, Issue:7 Topics: Adult; Agoraphobia; Anxiety Disorders; Arousal; Calcium; Epinephrine; Fear; Female; Heart Rate; Huma	1985
Specificity of lactate infusions in social phobia versus panic disorders. The American journal of psychiatry, 1985, Volume: 142, Issue:8 Topics: Adult; Agoraphobia; Anxiety Disorders; Diagnosis, Differential; Fear; Female; Humans; Infusions, Par	1985

lactic acid and Agoraphobia

Research Excerpts

Research

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