Page last updated: 2024-10-17

lactic acid and Age-Related Memory Disorders

lactic acid has been researched along with Age-Related Memory Disorders in 16 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"d-Lactic acidosis is associated with memory impairment in humans."3.76Increased plasma d-lactic acid associated with impaired memory in rats. ( Clayton, EH; Hanstock, TL; Mallet, PE, 2010)
"Curcumin is a natural product with several anti-Alzheimer's disease (AD) neuroprotective properties."1.51Curcumin Ameliorates Memory Deficits by Enhancing Lactate Content and MCT2 Expression in APP/PS1 Transgenic Mouse Model of Alzheimer's Disease. ( Gan, SW; Huang, J; Huang, SQ; Jiang, XL; Li, Y; Lu, WT; Qiu, GP; Sun, SQ; Xu, J; Xu, SY; Zhuo, F, 2019)
"The pre-training administration caused memory loss from the earliest time tested whereas memory was maintained for another 20 min when D-lactate was injected 10 min post-training."1.35Inhibition of astrocytic energy metabolism by D-lactate exposure impairs memory. ( Gibbs, ME; Hertz, L, 2008)
"Huperzine A is an anticholinesterase and cognitive enhancer, which is able to alleviate the symptoms of memory dysfunction in the mouse."1.34Prolonged effects of poly(lactic-co-glycolic acid) microsphere-containing huperzine A on mouse memory dysfunction induced by scopolamine. ( Fu, F; Liu, J; Liu, K; Ma, H; Wang, C; Zhang, T, 2007)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (6.25)18.2507
2000's4 (25.00)29.6817
2010's9 (56.25)24.3611
2020's2 (12.50)2.80

Authors

AuthorsStudies
Frame, AK1
Robinson, JW1
Mahmoudzadeh, NH1
Tennessen, JM1
Simon, AF1
Cumming, RC1
Akter, M1
Hasan, M1
Ramkrishnan, AS1
Iqbal, Z1
Zheng, X1
Fu, Z1
Lei, Z1
Karim, A1
Li, Y4
Kee, CK1
Ngam, PI1
Tan, AP1
Liguori, C1
Mercuri, NB1
Izzi, F1
Romigi, A1
Cordella, A1
Sancesario, G1
Placidi, F1
Jin, C1
Gao, L1
Wu, S1
Lu, X1
Yang, J1
Cai, Y1
Lu, WT1
Sun, SQ1
Xu, SY1
Gan, SW1
Xu, J1
Qiu, GP1
Zhuo, F1
Huang, SQ1
Jiang, XL1
Huang, J1
Descalzi, G1
Gao, V1
Steinman, MQ1
Suzuki, A1
Alberini, CM1
Martikainen, MH1
Ellfolk, U1
Majamaa, K1
Gibbs, ME2
Gibbs, Z1
Hertz, L2
Hanstock, TL1
Mallet, PE1
Clayton, EH1
Aguiar, AS1
Boemer, G1
Rial, D1
Cordova, FM1
Mancini, G1
Walz, R1
de Bem, AF1
Latini, A1
Leal, RB1
Pinho, RA1
Prediger, RD1
Hazekawa, M1
Sakai, Y1
Yoshida, M1
Haraguchi, T1
Uchida, T1
Wang, C1
Zhang, T1
Ma, H1
Liu, J1
Fu, F1
Liu, K1
Chu, D1
Tian, J1
Liu, W1
Li, Z1
Anezaki, T1
Yanagisawa, K1
Ibayashi, K1
Miyatake, T1

Other Studies

16 other studies available for lactic acid and Age-Related Memory Disorders

ArticleYear
Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies.
    Aging, 2023, 02-28, Volume: 15, Issue:4

    Topics: Animals; Astrocytes; Drosophila melanogaster; L-Lactate Dehydrogenase; Lactic Acid; Lipids; Memory D

2023
Astrocyte and L-lactate in the anterior cingulate cortex modulate schema memory and neuronal mitochondrial biogenesis.
    eLife, 2023, 11-14, Volume: 12

    Topics: Animals; Astrocytes; Gyrus Cinguli; Lactic Acid; Memory; Memory Disorders; Organelle Biogenesis; Rat

2023
An Unusual Cause of Stroke-Like Symptoms in an Elderly Patient.
    Annals of the Academy of Medicine, Singapore, 2019, Volume: 48, Issue:9

    Topics: Aphasia; Cerebral Angiography; Diagnosis, Differential; Electroencephalography; Humans; Lactic Acid;

2019
Obstructive Sleep Apnea is Associated With Early but Possibly Modifiable Alzheimer's Disease Biomarkers Changes.
    Sleep, 2017, 05-01, Volume: 40, Issue:5

    Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Cognition; Cognitive Dysfunction; Contin

2017
Lanthanum damages learning and memory and suppresses astrocyte-neuron lactate shuttle in rat hippocampus.
    Experimental brain research, 2017, Volume: 235, Issue:12

    Topics: Animals; Astrocytes; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gene Expressi

2017
Curcumin Ameliorates Memory Deficits by Enhancing Lactate Content and MCT2 Expression in APP/PS1 Transgenic Mouse Model of Alzheimer's Disease.
    Anatomical record (Hoboken, N.J. : 2007), 2019, Volume: 302, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents, Non-Steroidal;

2019
Lactate from astrocytes fuels learning-induced mRNA translation in excitatory and inhibitory neurons.
    Communications biology, 2019, Volume: 2

    Topics: Animals; Astrocytes; Avoidance Learning; Brain; Citric Acid Cycle; Gangliosides; Glycogenolysis; Hip

2019
Impaired information-processing speed and working memory in leukoencephalopathy with brainstem and spinal cord involvement and elevated lactate (LBSL) and DARS2 mutations: a report of three adult patients.
    Journal of neurology, 2013, Volume: 260, Issue:8

    Topics: Adolescent; Age of Onset; Aspartate-tRNA Ligase; Brain Stem; Child; Cognition; Disease Progression;

2013
Rescue of Abeta(1-42)-induced memory impairment in day-old chick by facilitation of astrocytic oxidative metabolism: implications for Alzheimer's disease.
    Journal of neurochemistry, 2009, Volume: 109 Suppl 1

    Topics: 3-Hydroxybutyric Acid; Acetates; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn

2009
Increased plasma d-lactic acid associated with impaired memory in rats.
    Physiology & behavior, 2010, Dec-02, Volume: 101, Issue:5

    Topics: Acidosis, Lactic; Analysis of Variance; Animals; Diet; Fermentation; Lactic Acid; Male; Memory Disor

2010
High-intensity physical exercise disrupts implicit memory in mice: involvement of the striatal glutathione antioxidant system and intracellular signaling.
    Neuroscience, 2010, Dec-29, Volume: 171, Issue:4

    Topics: Adaptation, Physiological; Analysis of Variance; Animals; Corpus Striatum; Disease Models, Animal; E

2010
The effect of treatment with a sustained-release prostacyclin analogue (ONO-1301-loaded PLGA microsphere) on short-term memory impairment in rats with transient global cerebral ischemia.
    Journal of microencapsulation, 2012, Volume: 29, Issue:3

    Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Delayed-Action Preparations; Disease Models, Anima

2012
Prolonged effects of poly(lactic-co-glycolic acid) microsphere-containing huperzine A on mouse memory dysfunction induced by scopolamine.
    Basic & clinical pharmacology & toxicology, 2007, Volume: 100, Issue:3

    Topics: Acetylcholinesterase; Alkaloids; Animals; Avoidance Learning; Cerebral Cortex; Delayed-Action Prepar

2007
Poly(lactic-co-glycolic acid) microspheres for the controlled release of huperzine A: in vitro and in vivo studies and the application in the treatment of the impaired memory of mice.
    Chemical & pharmaceutical bulletin, 2007, Volume: 55, Issue:4

    Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Lactic Acid; Memory Disorders; Mice; Microspheres; Po

2007
Inhibition of astrocytic energy metabolism by D-lactate exposure impairs memory.
    Neurochemistry international, 2008, Volume: 52, Issue:6

    Topics: Acetic Acid; Animals; Astrocytes; Brain; Chickens; Citric Acid Cycle; Energy Metabolism; Glutamic Ac

2008
A patient with severe iron-deficiency anemia and memory disturbance.
    Internal medicine (Tokyo, Japan), 1992, Volume: 31, Issue:11

    Topics: Anemia, Hypochromic; Diet; Female; Humans; Intelligence; Iron; Lactates; Lactic Acid; Memory Disorde

1992