lactic acid has been researched along with Aerobic Glycolysis, Oncologic in 10 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Proliferating cancer cells have high energy demands, which is mainly obtained through glycolysis." | 2.72 | In Vivo Anticancer Activity of AZD3965: A Systematic Review. ( Afonso, J; Antunes, B; Baltazar, F; Batista, A; Pinto-Ribeiro, F; Silva, A, 2021) |
| "The Warburg effect is the preference of cancer cell for glycolysis that produces lactate even when sufficient oxygen is provided." | 2.72 | Protein networks linking Warburg and reverse Warburg effects to cancer cell metabolism. ( Bernstein, LH; Elberry, MH; Elmehrath, AO; Johar, D; Khalil, RM; Shalabi, SA; Zaky, S, 2021) |
| "It is widely acknowledged that cancer cell energy metabolism relies mainly on anaerobic glycolysis; this phenomenon is described as the Warburg effect." | 2.66 | Revisiting the Warburg Effect: Diet-Based Strategies for Cancer Prevention. ( Gong, N; Kim, C; Kim, SH; Kong, G; Kwon, SH; Lee, H; Park, J; Tran, Q, 2020) |
| "For muscle-invasive bladder cancer (MIBC), treatment includes radical cystectomy, radiotherapy, and chemotherapy; however, the outcome is generally poor." | 1.62 | The Warburg effect as a therapeutic target for bladder cancers and intratumoral heterogeneity in associated molecular targets. ( Allison, SJ; Burns, JE; Hurst, CD; Knowles, MA; Phillips, RM, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 10 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Su, X | 1 |
| Yang, Y | 1 |
| Yang, Q | 1 |
| Pang, B | 1 |
| Sun, S | 1 |
| Wang, Y | 1 |
| Qiao, Q | 1 |
| Guo, C | 1 |
| Liu, H | 1 |
| Pang, Q | 1 |
| Silva, A | 1 |
| Antunes, B | 1 |
| Batista, A | 1 |
| Pinto-Ribeiro, F | 1 |
| Baltazar, F | 1 |
| Afonso, J | 1 |
| Altinok, O | 1 |
| Poggio, JL | 1 |
| Stein, DE | 1 |
| Bowne, WB | 1 |
| Shieh, AC | 1 |
| Snyder, NW | 1 |
| Orynbayeva, Z | 1 |
| Brooks, GA | 1 |
| Fu, R | 1 |
| Yang, P | 1 |
| Amin, S | 1 |
| Li, Z | 1 |
| Tran, Q | 1 |
| Lee, H | 1 |
| Kim, C | 1 |
| Kong, G | 1 |
| Gong, N | 1 |
| Kwon, SH | 1 |
| Park, J | 2 |
| Kim, SH | 1 |
| Tailor, D | 1 |
| Going, CC | 1 |
| Resendez, A | 1 |
| Kumar, V | 1 |
| Nambiar, DK | 1 |
| Li, Y | 1 |
| Dheeraj, A | 1 |
| LaGory, EL | 1 |
| Ghoochani, A | 1 |
| Birk, AM | 1 |
| Stoyanova, T | 1 |
| Ye, J | 1 |
| Giaccia, AJ | 1 |
| Le, QT | 1 |
| Singh, RP | 1 |
| Sledge, GW | 1 |
| Pitteri, SJ | 1 |
| Malhotra, SV | 1 |
| Jiang, X | 1 |
| Yuan, J | 1 |
| Dou, Y | 1 |
| Zeng, D | 1 |
| Xiao, S | 1 |
| Burns, JE | 1 |
| Hurst, CD | 1 |
| Knowles, MA | 1 |
| Phillips, RM | 1 |
| Allison, SJ | 1 |
| Johar, D | 1 |
| Elmehrath, AO | 1 |
| Khalil, RM | 1 |
| Elberry, MH | 1 |
| Zaky, S | 1 |
| Shalabi, SA | 1 |
| Bernstein, LH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Physiological Effects of Lactate in Individuals With Chronic Heart Failure[NCT06121323] | 12 participants (Anticipated) | Interventional | 2023-11-22 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for lactic acid and Aerobic Glycolysis, Oncologic
| Article | Year |
|---|---|
In Vivo Anticancer Activity of AZD3965: A Systematic Review.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Management; Disease Progression; Drug Eval | 2021 |
The tortuous path of lactate shuttle discovery: From cinders and boards to the lab and ICU.
Topics: Anaerobiosis; Blood Glucose; Critical Care; Cytosol; Endurance Training; Fatty Acids; Glycolysis; Hu | 2020 |
Revisiting the Warburg Effect: Diet-Based Strategies for Cancer Prevention.
Topics: Animals; Caloric Restriction; Clinical Trials as Topic; Diet; Glycolysis; Humans; Lactic Acid; Neopl | 2020 |
Protein networks linking Warburg and reverse Warburg effects to cancer cell metabolism.
Topics: Animals; Epithelial Cells; Glycolysis; Humans; Lactic Acid; Mice; Neoplasms; Warburg Effect, Oncolog | 2021 |
6 other studies available for lactic acid and Aerobic Glycolysis, Oncologic
| Article | Year |
|---|---|
NOX4-derived ROS-induced overexpression of FOXM1 regulates aerobic glycolysis in glioblastoma.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Brain; Brain Neoplasms; Cell Line, Tumor; Forkhe | 2021 |
Malate-aspartate shuttle promotes l-lactate oxidation in mitochondria.
Topics: Aspartic Acid; Colonic Neoplasms; HCT116 Cells; Homeostasis; Humans; Lactic Acid; Malates; Mitochond | 2020 |
A novel miR-206/hnRNPA1/PKM2 axis reshapes the Warburg effect to suppress colon cancer growth.
Topics: Alternative Splicing; Carrier Proteins; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Gene Exp | 2020 |
Novel Aza-podophyllotoxin derivative induces oxidative phosphorylation and cell death via AMPK activation in triple-negative breast cancer.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Death; Ce | 2021 |
Lipopolysaccharide Affects the Proliferation and Glucose Metabolism of Cervical Cancer Cells Through the FRA1/MDM2/p53 Pathway.
Topics: Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cervix Uteri; Female; Gene Expression Regulati | 2021 |
The Warburg effect as a therapeutic target for bladder cancers and intratumoral heterogeneity in associated molecular targets.
Topics: Apoptosis; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Gene Knockdown Techniques; Humans; I | 2021 |