lactic acid has been researched along with Adverse Drug Event in 21 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Poly-L-lactic acid (PLLA) is an injectable filler used for the treatment of facial fat loss secondary to HIV and aging." | 9.12 | Safety and efficacy of poly-L-lactic acid in HIV lipoatrophy and lipoatrophy of aging. ( Hanke, CW; Redbord, KP, 2007) |
| "Poly-L-lactic acid (PLLA) is an injectable filler used for the treatment of facial fat loss secondary to HIV and aging." | 5.12 | Safety and efficacy of poly-L-lactic acid in HIV lipoatrophy and lipoatrophy of aging. ( Hanke, CW; Redbord, KP, 2007) |
| " It frequently causes peripheral neuropathy and lipodystrophy and increases the risk of lactic acidosis and other high lactate syndromes." | 3.79 | Longitudinal lactate levels from routine point-of-care monitoring in adult Malawian antiretroviral therapy patients: associations with stavudine toxicities. ( Chagoma, N; Heyderman, RS; Kampira, E; Kaunda, S; Mallewa, J; Mukaka, M; Njalale, Y; van Oosterhout, JJ, 2013) |
| "Lactic acid gel was associated with fewer reported side effects." | 3.30 | Intravaginal lactic acid gel versus oral metronidazole for treating women with recurrent bacterial vaginosis: the VITA randomised controlled trial. ( Abdali, Z; Anstey Watkins, J; Armstrong-Buisseret, LK; Brittain, C; Daniels, J; David, M; Dean, G; Griffiths, F; Hepburn, TM; Jackson, L; Kai, J; Manley, A; Montgomery, A; Ozolins, M; Ross, JDC, 2023) |
| " An OGTT was performed in 30 subjects: 16 HIV-infected treated patients without adverse events (group 1) and 14 HIV-infected patients with adverse events related to nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity (group 2)." | 2.73 | Oral glucose loading for detection of mitochondrial toxicity during HAART in HIV-infected patients. ( Borm, GF; Koopmans, PP; ter Hofstede, HJ, 2007) |
| "Hyperlactatemia is common in critically ill patients and has a variety of etiologies." | 2.55 | Drug-induced hyperlactatemia. ( Blohm, E; Lai, J; Neavyn, M, 2017) |
| " Our results show that Erlotinib-HCl delivered in the form of nanoparticles has less toxic effect than the free drug in experimental rats." | 1.35 | Poly(D,L-lactic-co-glycolic acid) nanoencapsulation reduces Erlotinib-induced subacute toxicity in rat. ( Franklin, G; Kalaichelvan, VK; Manavalan, R; Marslin, G; Reddy, PN; Sheeba, CJ, 2009) |
| "Nucleoside analogues can induce toxic effects on mitochondria by inhibiting the human DNA polymerase gamma." | 1.31 | Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients. ( Alexander, CS; Brumme, ZL; Côté, HC; Craib, KJ; Harrigan, PR; Harris, M; Montaner, JS; O'Shaughnessy, MV; Ting, L; Wong, H; Wynhoven, B, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.76) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (47.62) | 29.6817 |
| 2010's | 9 (42.86) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Ross, JDC | 1 |
| Brittain, C | 1 |
| Anstey Watkins, J | 1 |
| Kai, J | 1 |
| David, M | 1 |
| Ozolins, M | 1 |
| Jackson, L | 1 |
| Abdali, Z | 1 |
| Hepburn, TM | 1 |
| Griffiths, F | 1 |
| Montgomery, A | 1 |
| Daniels, J | 1 |
| Manley, A | 1 |
| Dean, G | 1 |
| Armstrong-Buisseret, LK | 1 |
| Blohm, E | 1 |
| Lai, J | 1 |
| Neavyn, M | 1 |
| Leung, YH | 1 |
| Belanger, F | 1 |
| Lu, J | 1 |
| Turgeon, J | 1 |
| Michaud, V | 1 |
| Pino, A | 1 |
| Bartolo, E | 1 |
| Caggia, C | 1 |
| Cianci, A | 1 |
| Randazzo, CL | 1 |
| Chagoma, N | 1 |
| Mallewa, J | 1 |
| Kaunda, S | 1 |
| Njalale, Y | 1 |
| Kampira, E | 1 |
| Mukaka, M | 1 |
| Heyderman, RS | 1 |
| van Oosterhout, JJ | 1 |
| Andersen, LW | 1 |
| Mackenhauer, J | 1 |
| Roberts, JC | 1 |
| Berg, KM | 1 |
| Cocchi, MN | 1 |
| Donnino, MW | 1 |
| Love, IY | 1 |
| Perl, S | 1 |
| Rapoport, MJ | 1 |
| Narciso, P | 1 |
| Bucciardini, R | 1 |
| Tozzi, V | 1 |
| Bellagamba, R | 1 |
| Ivanovic, J | 1 |
| Giulianelli, M | 1 |
| Scevola, S | 1 |
| Palummieri, A | 1 |
| Fragola, V | 1 |
| Massella, M | 1 |
| Fracasso, L | 1 |
| De Vita, R | 1 |
| Pierro, P | 1 |
| Del Maestro, A | 1 |
| Mirra, M | 1 |
| Weimer, L | 1 |
| Marslin, G | 1 |
| Sheeba, CJ | 1 |
| Kalaichelvan, VK | 1 |
| Manavalan, R | 1 |
| Reddy, PN | 1 |
| Franklin, G | 1 |
| Limonciel, A | 1 |
| Aschauer, L | 1 |
| Wilmes, A | 1 |
| Prajczer, S | 1 |
| Leonard, MO | 1 |
| Pfaller, W | 1 |
| Jennings, P | 1 |
| Dicks, LM | 1 |
| Botes, M | 1 |
| Mueller, D | 1 |
| Müller-Vieira, U | 1 |
| Biemel, KM | 1 |
| Tascher, G | 1 |
| Nüssler, AK | 1 |
| Noor, F | 1 |
| Chariot, P | 1 |
| Bourokba, N | 1 |
| Brivet, F | 1 |
| Rastegar, DA | 1 |
| Casademont, J | 1 |
| Miró, O | 1 |
| Cardellach, F | 1 |
| CARR, CJ | 2 |
| COSMIDES, GJ | 2 |
| MIYA, TS | 2 |
| Tashibu, H | 1 |
| Miyazaki, H | 1 |
| Aoki, K | 1 |
| Akie, Y | 1 |
| Yamamoto, K | 1 |
| Finkelstein, Y | 1 |
| Rezvani, M | 1 |
| Garcia-Bournissen, F | 1 |
| Nurmohamed, L | 1 |
| Koren, G | 1 |
| Hanke, CW | 1 |
| Redbord, KP | 1 |
| ter Hofstede, HJ | 1 |
| Borm, GF | 1 |
| Koopmans, PP | 1 |
| Côté, HC | 1 |
| Brumme, ZL | 1 |
| Craib, KJ | 1 |
| Alexander, CS | 1 |
| Wynhoven, B | 1 |
| Ting, L | 1 |
| Wong, H | 1 |
| Harris, M | 1 |
| Harrigan, PR | 1 |
| O'Shaughnessy, MV | 1 |
| Montaner, JS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Intra Aortic Balloon Pump Early Insertion on Mortality in Post Cardiac Arrest Patients With Acute Coronary Syndrome[NCT03638609] | 102 participants (Anticipated) | Interventional | 2017-10-23 | Recruiting | |||
| The Relationship of Anesthesia Method With Serum Lactate Level in Craniotomies[NCT05145049] | 110 participants (Actual) | Observational [Patient Registry] | 2021-11-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for lactic acid and Adverse Drug Event
| Article | Year |
|---|---|
Drug-induced hyperlactatemia.
Topics: Biomarkers; Drug-Related Side Effects and Adverse Reactions; Energy Metabolism; Humans; Hyperlactate | 2017 |
Etiology and therapeutic approach to elevated lactate levels.
Topics: Biomarkers; Drug-Related Side Effects and Adverse Reactions; Heart Arrest; Humans; Lactic Acid; PubM | 2013 |
Etiology and therapeutic approach to elevated lactate levels.
Topics: Biomarkers; Drug-Related Side Effects and Adverse Reactions; Heart Arrest; Humans; Lactic Acid; PubM | 2013 |
Etiology and therapeutic approach to elevated lactate levels.
Topics: Biomarkers; Drug-Related Side Effects and Adverse Reactions; Heart Arrest; Humans; Lactic Acid; PubM | 2013 |
Etiology and therapeutic approach to elevated lactate levels.
Topics: Biomarkers; Drug-Related Side Effects and Adverse Reactions; Heart Arrest; Humans; Lactic Acid; PubM | 2013 |
Probiotic lactic acid bacteria in the gastro-intestinal tract: health benefits, safety and mode of action.
Topics: Bacteria; Drug-Related Side Effects and Adverse Reactions; Gastrointestinal Tract; Humans; Insurance | 2010 |
Inactive pharmaceutical ingredients : implications for pregnancy.
Topics: Abnormalities, Drug-Induced; Adjuvants, Pharmaceutic; Canada; Drug Compounding; Drug Labeling; Drug- | 2007 |
4 trials available for lactic acid and Adverse Drug Event
| Article | Year |
|---|---|
Intravaginal lactic acid gel versus oral metronidazole for treating women with recurrent bacterial vaginosis: the VITA randomised controlled trial.
Topics: Ambulatory Care Facilities; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Lactic | 2023 |
Immediate versus delayed surgical intervention for reconstructive therapy of HIV-associated facial lipoatrophy: a randomized open-label study.
Topics: Acrylic Resins; Adult; Aged; Drug-Related Side Effects and Adverse Reactions; Female; Gels; HIV Infe | 2009 |
Safety and efficacy of poly-L-lactic acid in HIV lipoatrophy and lipoatrophy of aging.
Topics: Adult; Aged; Aged, 80 and over; Aging; Case-Control Studies; Drug-Related Side Effects and Adverse R | 2007 |
Oral glucose loading for detection of mitochondrial toxicity during HAART in HIV-infected patients.
Topics: Adult; Antiretroviral Therapy, Highly Active; Drug-Related Side Effects and Adverse Reactions; Femal | 2007 |
13 other studies available for lactic acid and Adverse Drug Event
| Article | Year |
|---|---|
Effects of a Series of Acidic Drugs on L-Lactic Acid Transport by the Monocarboxylate Transporters MCT1 and MCT4.
Topics: Animals; Biological Transport; Cell Culture Techniques; Cell Line, Tumor; Drug-Related Side Effects | 2017 |
Detection of vaginal lactobacilli as probiotic candidates.
Topics: Bacterial Adhesion; Caco-2 Cells; Drug Stability; Drug-Related Side Effects and Adverse Reactions; E | 2019 |
Longitudinal lactate levels from routine point-of-care monitoring in adult Malawian antiretroviral therapy patients: associations with stavudine toxicities.
Topics: Acidosis, Lactic; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cohort Studies; Dru | 2013 |
A Rare Case of Caffeine Storm due to Excessive Coca-Cola Consumption.
Topics: Adult; Caffeine; Central Nervous System Stimulants; Diabetic Ketoacidosis; Diagnosis, Differential; | 2016 |
Poly(D,L-lactic-co-glycolic acid) nanoencapsulation reduces Erlotinib-induced subacute toxicity in rat.
Topics: Animals; Dose-Response Relationship, Drug; Drug Compounding; Drug-Related Side Effects and Adverse R | 2009 |
Lactate is an ideal non-invasive marker for evaluating temporal alterations in cell stress and toxicity in repeat dose testing regimes.
Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Biomarkers; Cell Line; Cell Line, Tumor; Cell Survival; | 2011 |
Biotransformation of diclofenac and effects on the metabolome of primary human hepatocytes upon repeated dose exposure.
Topics: 3-Hydroxybutyric Acid; Biotransformation; Cells, Cultured; Cytochrome P-450 Enzyme System; Diclofena | 2012 |
Mitochondrial DNA and nucleoside toxicity.
Topics: Anti-HIV Agents; Dideoxynucleosides; DNA, Mitochondrial; Drug Therapy, Combination; Drug-Related Sid | 2002 |
Mitochondrial DNA and nucleoside toxicity.
Topics: Anti-HIV Agents; DNA; DNA, Mitochondrial; Drug-Related Side Effects and Adverse Reactions; Genetic M | 2002 |
Mitochondrial DNA and nucleoside toxicity.
Topics: Anti-HIV Agents; Dideoxynucleosides; DNA; DNA, Mitochondrial; Drug-Related Side Effects and Adverse | 2002 |
A study of the effects of certain lactones on digitoxin toxicity.
Topics: Cardiovascular Agents; Digitalis; Digitoxin; Drug-Related Side Effects and Adverse Reactions; Lactic | 1956 |
A study of the effects of certain lactones on digitoxin toxicity.
Topics: Cardiovascular Agents; Digitalis; Digitoxin; Drug-Related Side Effects and Adverse Reactions; Lactic | 1956 |
A study of the effects of certain lactones on digitoxin toxicity.
Topics: Cardiovascular Agents; Digitalis; Digitoxin; Drug-Related Side Effects and Adverse Reactions; Lactic | 1956 |
A study of the effects of certain lactones on digitoxin toxicity.
Topics: Cardiovascular Agents; Digitalis; Digitoxin; Drug-Related Side Effects and Adverse Reactions; Lactic | 1956 |
QT PRODACT: in vivo QT assay in anesthetized dog for detecting the potential for QT interval prolongation by human pharmaceuticals.
Topics: Anesthetics, Inhalation; Animals; Databases, Factual; Dogs; Drug-Related Side Effects and Adverse Re | 2005 |
Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients.
Topics: Adult; Anti-HIV Agents; Dideoxynucleosides; DNA; DNA, Mitochondrial; Drug Therapy, Combination; Drug | 2002 |