lactic acid has been researched along with Adjuvant Arthritis in 24 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methotrexate (MTX), as a disease modifying antirheumatic drug (DMARD), was first line drug to treat rheumatoid arthritis." | 3.88 | Dual-functional lipid polymeric hybrid pH-responsive nanoparticles decorated with cell penetrating peptide and folate for therapy against rheumatoid arthritis. ( Lee, RJ; Li, Y; Sun, F; Sun, X; Teng, L; Yu, C; Zhang, X; Zhao, J; Zhao, M; Zhou, Y, 2018) |
| "To evaluate the efficacy of a single intra-articular (IA) dose of FX006, an extended-release formulation of triamcinolone acetonide (TCA) in poly(lactic-co-glycolic acid) (PLGA) microspheres, on the sequelae of repeated episodes of synovitis." | 3.81 | Sustained efficacy of a single intra-articular dose of FX006 in a rat model of repeated localized knee arthritis. ( Bendele, AM; Blanks, RC; Bodick, N; Kumar, A, 2015) |
| ", samples with HMGB-1 levels >2 SD above the mean level in samples from patients with noninflammatory arthropathy), concentrations of HMGB-1 were significantly correlated with those of lactic acid, a marker of tissue hypoxia." | 3.74 | Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis. ( Abeyama, K; Fukuda, T; Fukuzaki, K; Hamada, T; Hashiguchi, K; Horai, N; Komiya, S; Kuwazuru, A; Maruyama, I; Nagata, R; Nagayama, S; Sunahara, N; Tanaka, M; Torikai, M; Yamada, S, 2008) |
| " In addition, proper siRNA dosing seems to be important for a positive therapeutic outcome in vivo." | 1.38 | MRI-assessed therapeutic effects of locally administered PLGA nanoparticles loaded with anti-inflammatory siRNA in a murine arthritis model. ( Colombo, S; Foged, C; Jensen, LB; Lammers, T; Nicolay, K; Nielsen, HM; Schiffelers, RM; Storm, G; Strijkers, GJ; te Boekhorst, BC; Varkouhi, AK, 2012) |
| "Rats with adjuvant arthritis (AA rats) and mice with anti-type II collagen antibody induced arthritis (AbIA mice) were treated intravenously with PLGA-nanosteroid after the initial sign of arthritis." | 1.33 | Treatment of experimental arthritis with poly(D, L-lactic/glycolic acid) nanoparticles encapsulating betamethasone sodium phosphate. ( Higaki, M; Ishihara, T; Izumo, N; Mizushima, Y; Takatsu, M, 2005) |
| "Triptolide (TP), which has potent immunosuppressive effects, anti-inflammatory and severe toxicity on digestive, urogenital, blood circulatory system, was used as a model drug in this study." | 1.33 | Anti-inflammatory effects of triptolide loaded poly(D,L-lactic acid) nanoparticles on adjuvant-induced arthritis in rats. ( Dong, J; Liu, M; Xu, H; Yang, X; Yang, Y, 2005) |
| " Consequently, the release rate of CyA from PLA microspheres can be improved by adding fatty acid esters and PLA microspheres with fatty acid esters seem to be a useful dosage form for autoimmune disease therapy." | 1.30 | Modification of release rates of cyclosporin A from polyl(L-lactic acid) microspheres by fatty acid esters and in-vivo evaluation of the microspheres. ( Arimori, K; Nakano, H; Urata, T, 1999) |
| " Injectable microspheres and in situ gel-forming implant systems of PLG (50:50) copolymer may therefore be considered as prospective implantable controlled-release dosage forms to deliver drugs in long-term therapy of chronic ailments." | 1.29 | Biodegradable injectable implant systems for long term drug delivery using poly (lactic-co-glycolic) acid copolymers. ( Chandrashekar, G; Udupa, N, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (12.50) | 18.2507 |
| 2000's | 9 (37.50) | 29.6817 |
| 2010's | 12 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, J | 2 |
| Zhang, X | 2 |
| Sun, X | 1 |
| Zhao, M | 1 |
| Yu, C | 1 |
| Lee, RJ | 1 |
| Sun, F | 1 |
| Zhou, Y | 1 |
| Li, Y | 1 |
| Teng, L | 1 |
| Finn, A | 2 |
| Angeby Möller, K | 1 |
| Gustafsson, C | 1 |
| Abdelmoaty, S | 1 |
| Nordahl, G | 1 |
| Ferm, M | 1 |
| Svensson, C | 1 |
| Kumar, A | 1 |
| Bendele, AM | 1 |
| Blanks, RC | 1 |
| Bodick, N | 1 |
| Yamaoka, K | 1 |
| Sonomoto, K | 1 |
| Kaneko, H | 1 |
| Satake, M | 1 |
| Yamamoto, Y | 1 |
| Kondo, M | 1 |
| Miyagawa, I | 1 |
| Yamagata, K | 1 |
| Fukuyo, S | 1 |
| Okada, Y | 1 |
| Tanaka, Y | 1 |
| Fujii, W | 1 |
| Kawahito, Y | 1 |
| Nagahara, H | 1 |
| Kukida, Y | 1 |
| Seno, T | 1 |
| Yamamoto, A | 1 |
| Kohno, M | 1 |
| Oda, R | 1 |
| Taniguchi, D | 1 |
| Fujiwara, H | 1 |
| Ejima, A | 1 |
| Kishida, T | 1 |
| Mazda, O | 1 |
| Ashihara, E | 1 |
| El-Setouhy, DA | 1 |
| Abdelmalak, NS | 1 |
| Anis, SE | 1 |
| Louis, D | 1 |
| Kishimoto, TK | 1 |
| Ferrari, JD | 1 |
| LaMothe, RA | 1 |
| Kolte, PN | 1 |
| Griset, AP | 1 |
| O'Neil, C | 1 |
| Chan, V | 1 |
| Browning, E | 1 |
| Chalishazar, A | 1 |
| Kuhlman, W | 1 |
| Fu, FN | 1 |
| Viseux, N | 1 |
| Altreuter, DH | 1 |
| Johnston, L | 1 |
| Maldonado, RA | 1 |
| Goto, N | 1 |
| Okazaki, K | 1 |
| Akasaki, Y | 1 |
| Ishihara, K | 1 |
| Murakami, K | 1 |
| Koyano, K | 1 |
| Ayukawa, Y | 1 |
| Yasunami, N | 1 |
| Masuzaki, T | 1 |
| Nakashima, Y | 1 |
| Hamada, T | 1 |
| Torikai, M | 1 |
| Kuwazuru, A | 1 |
| Tanaka, M | 1 |
| Horai, N | 1 |
| Fukuda, T | 2 |
| Yamada, S | 1 |
| Nagayama, S | 1 |
| Hashiguchi, K | 1 |
| Sunahara, N | 1 |
| Fukuzaki, K | 1 |
| Nagata, R | 1 |
| Komiya, S | 1 |
| Maruyama, I | 1 |
| Abeyama, K | 1 |
| Belova, SV | 1 |
| Kariakina, EV | 1 |
| Ishihara, T | 2 |
| Kubota, T | 1 |
| Choi, T | 1 |
| Higaki, M | 2 |
| Oerther, SC | 1 |
| MacKenzie, JD | 1 |
| Yen, YF | 1 |
| Mayer, D | 1 |
| Tropp, JS | 1 |
| Hurd, RE | 1 |
| Spielman, DM | 1 |
| te Boekhorst, BC | 1 |
| Jensen, LB | 1 |
| Colombo, S | 1 |
| Varkouhi, AK | 1 |
| Schiffelers, RM | 1 |
| Lammers, T | 1 |
| Storm, G | 1 |
| Nielsen, HM | 1 |
| Strijkers, GJ | 1 |
| Foged, C | 1 |
| Nicolay, K | 1 |
| Présumey, J | 1 |
| Salzano, G | 1 |
| Courties, G | 1 |
| Shires, M | 1 |
| Ponchel, F | 1 |
| Jorgensen, C | 1 |
| Apparailly, F | 1 |
| De Rosa, G | 1 |
| Yassuda Filho, P | 1 |
| Bracht, A | 3 |
| Ishii-Iwamoto, EL | 3 |
| Lousano, SH | 1 |
| Bracht, L | 1 |
| Kelmer-Bracht, AM | 3 |
| Izumo, N | 1 |
| Takatsu, M | 1 |
| Mizushima, Y | 1 |
| Liu, M | 1 |
| Dong, J | 1 |
| Yang, Y | 1 |
| Yang, X | 1 |
| Xu, H | 1 |
| Chandrashekar, G | 1 |
| Udupa, N | 1 |
| Urata, T | 1 |
| Arimori, K | 1 |
| Nakano, H | 1 |
| Fedatto Júnior, Z | 1 |
| Amado, CB | 1 |
| Vicentini, GE | 2 |
| Panerari, AD | 1 |
| Fedatto-Júnior, Z | 1 |
| Caparroz-Assef, SM | 1 |
| Kim, WU | 1 |
| Lee, WK | 1 |
| Ryoo, JW | 1 |
| Kim, SH | 1 |
| Kim, J | 1 |
| Youn, J | 1 |
| Min, SY | 1 |
| Bae, EY | 1 |
| Hwang, SY | 1 |
| Park, SH | 1 |
| Cho, CS | 1 |
| Park, JS | 1 |
| Kim, HY | 1 |
| Horisawa, E | 1 |
| Hirota, T | 1 |
| Kawazoe, S | 1 |
| Yamada, J | 1 |
| Yamamoto, H | 1 |
| Takeuchi, H | 1 |
| Kawashima, Y | 1 |
24 other studies available for lactic acid and Adjuvant Arthritis
| Article | Year |
|---|---|
Dual-functional lipid polymeric hybrid pH-responsive nanoparticles decorated with cell penetrating peptide and folate for therapy against rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arginine; Arthritis, Experimental; Arthritis, Rheumatoid; Cell-Penetr | 2018 |
Influence of model and matrix on cytokine profile in rat and human.
Topics: Aged; Aged, 80 and over; Animals; Arthritis, Experimental; Biomarkers; Cytokines; Female; Freund's A | 2014 |
Sustained efficacy of a single intra-articular dose of FX006 in a rat model of repeated localized knee arthritis.
Topics: Animals; Arthritis, Experimental; Glucocorticoids; Injections, Intra-Articular; Knee Joint; Lactic A | 2015 |
Local delivery of mesenchymal stem cells with poly-lactic-co-glycolic acid nano-fiber scaffold suppress arthritis in rats.
Topics: Adult; Animals; Arthritis, Experimental; CD4-Positive T-Lymphocytes; Cell Proliferation; Cytokines; | 2014 |
Monocarboxylate transporter 4, associated with the acidification of synovial fluid, is a novel therapeutic target for inflammatory arthritis.
Topics: Aged; Animals; Apoptosis; Arthritis, Experimental; Arthritis, Rheumatoid; Cartilage, Articular; Fema | 2015 |
Leflunomide biodegradable microspheres intended for intra-articular administration: Development, anti-inflammatory activity and histopathological studies.
Topics: Animals; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Experimental; Chemistry, Pharmac | 2015 |
Improving the efficacy and safety of biologic drugs with tolerogenic nanoparticles.
Topics: Adalimumab; Anaphylaxis; Animals; Arthritis, Experimental; Bone Resorption; Drug Delivery Systems; F | 2016 |
Single intra-articular injection of fluvastatin-PLGA microspheres reduces cartilage degradation in rabbits with experimental osteoarthritis.
Topics: Animals; Anticholesteremic Agents; Arthritis, Experimental; Cartilage, Articular; Chondrocytes; Drug | 2017 |
Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis.
Topics: Adult; Aged; Aged, 80 and over; Animals; Arthritis; Arthritis, Experimental; Blotting, Western; Cell | 2008 |
[Condition of oxidation homeostasis and possibility of its correction in experimental rheumatoid arthritis].
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Ceruloplasmin; Homeostasis; Hydrogen Peroxi | 2008 |
Treatment of experimental arthritis with stealth-type polymeric nanoparticles encapsulating betamethasone phosphate.
Topics: Animals; Arthritis, Experimental; Betamethasone; Drug Carriers; Drug Compounding; Female; Glucocorti | 2009 |
Can L(+)-lactate be used as a marker of experimentally induced inflammation in rats?
Topics: Animals; Arthritis, Experimental; Biomarkers; Carrageenan; Cyclooxygenase 2 Inhibitors; Cyclooxygena | 2010 |
Detection of inflammatory arthritis by using hyperpolarized 13C-pyruvate with MR imaging and spectroscopy.
Topics: Animals; Arthritis, Experimental; Biomarkers; Carbon Isotopes; Contrast Media; Disease Models, Anima | 2011 |
MRI-assessed therapeutic effects of locally administered PLGA nanoparticles loaded with anti-inflammatory siRNA in a murine arthritis model.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Bone Marrow; Cell Line; Drug Carriers; Fatt | 2012 |
PLGA microspheres encapsulating siRNA anti-TNFalpha: efficient RNAi-mediated treatment of arthritic joints.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Line; Drug Design; Lactic Acid; Mice; | 2012 |
The urea cycle in the liver of arthritic rats.
Topics: Ammonia; Animals; Arthritis, Experimental; Aspartic Acid; Citrulline; Dose-Response Relationship, Dr | 2003 |
Treatment of experimental arthritis with poly(D, L-lactic/glycolic acid) nanoparticles encapsulating betamethasone sodium phosphate.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Betamethasone; Delayed-Action Preparatio | 2005 |
Anti-inflammatory effects of triptolide loaded poly(D,L-lactic acid) nanoparticles on adjuvant-induced arthritis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chemistry, Pharmaceutical | 2005 |
Biodegradable injectable implant systems for long term drug delivery using poly (lactic-co-glycolic) acid copolymers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Arthritis, Experimental; Biocomp | 1996 |
Modification of release rates of cyclosporin A from polyl(L-lactic acid) microspheres by fatty acid esters and in-vivo evaluation of the microspheres.
Topics: Animals; Arthritis, Experimental; Body Weight; Cyclosporine; Drug Delivery Systems; Fatty Acids; Hin | 1999 |
Gluconeogenesis in the liver of arthritic rats.
Topics: Alanine; Animals; Arthritis, Experimental; Gluconeogenesis; Glucose; Glutamine; Glycerol; Lactic Aci | 1999 |
Glycogen levels and glycogen catabolism in livers from arthritic rats.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arthritis, Experimental; Blood Glucose; Cycl | 2002 |
Suppression of collagen-induced arthritis by single administration of poly(lactic-co-glycolic acid) nanoparticles entrapping type II collagen: a novel treatment strategy for induction of oral tolerance.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoimmunity; Biocompatible Materials; Catt | 2002 |
Prolonged anti-inflammatory action of DL-lactide/glycolide copolymer nanospheres containing betamethasone sodium phosphate for an intra-articular delivery system in antigen-induced arthritic rabbit.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Betamethasone; Drug Deliv | 2002 |