lactic acid has been researched along with Adenocarcinoma in 62 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Adenocarcinoma: A malignant epithelial tumor with a glandular organization.
Excerpt | Relevance | Reference |
---|---|---|
"Resistance to gemcitabine remains a key challenge in the treatment of pancreatic ductal adenocarcinoma (PDAC), necessitating the constant search for effective strategies for a priori prediction of clinical outcome." | 7.88 | Metabolomic prediction of treatment outcome in pancreatic ductal adenocarcinoma patients receiving gemcitabine. ( Alkaff, SMF; Chan, CY; Chan, ECY; Goh, S; Kam, JH; Leow, WQ; Lim, TKH; Phua, LC; Tai, DWM, 2018) |
" In this work CUR-NPs (curcumin-loaded lipid-polymer-lecithin hybrid nanoparticles) were synthesized and functionalized with ribonucleic acid (RNA) Aptamers (Apts) against epithelial cell adhesion molecule (EpCAM) for targeted delivery to colorectal adenocarcinoma cells." | 7.80 | Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells. ( Duan, W; Li, L; Li, Q; Lin, J; Liu, K; Shigdar, S; Xiang, D; Yang, W, 2014) |
" Mutations in the tyrosine kinase epidermal growth factor receptor (EGFR) induce oncogenic addiction in lung adenocarcinoma (LAD)." | 7.80 | Epidermal growth factor receptor (EGFR) signaling regulates global metabolic pathways in EGFR-mutated lung adenocarcinoma. ( Esumi, H; Makinoshima, H; Matsumoto, S; Owada, S; Takita, M; Tsuchihara, K; Yagishita, A, 2014) |
" However, due to its minimal water solubility, it is necessary to prepare an optimal nano-sized vehicle to overcome the low bioavailability issue." | 5.72 | Design and Development of a New Type of Hybrid PLGA/Lipid Nanoparticle as an Ursolic Acid Delivery System against Pancreatic Ductal Adenocarcinoma Cells. ( Gubernator, J; Jaromin, A; Markowski, A; Migdał, P; Olczak, E; Pawlik, K; Zaremba-Czogalla, M; Zygmunt, A, 2022) |
"Metabolic profiles of human colon cancer cells have been extensively studied, but comparison with non-tumour counterparts has been neglected." | 5.40 | Validation of NCM460 cell model as control in antitumor strategies targeting colon adenocarcinoma metabolic reprogramming: trichostatin A as a case study. ( Alcarraz-Vizán, G; Cascante, M; Moyer, MP; Sánchez-Tena, S, 2014) |
"Resistance to gemcitabine remains a key challenge in the treatment of pancreatic ductal adenocarcinoma (PDAC), necessitating the constant search for effective strategies for a priori prediction of clinical outcome." | 3.88 | Metabolomic prediction of treatment outcome in pancreatic ductal adenocarcinoma patients receiving gemcitabine. ( Alkaff, SMF; Chan, CY; Chan, ECY; Goh, S; Kam, JH; Leow, WQ; Lim, TKH; Phua, LC; Tai, DWM, 2018) |
" While age was found to be a significant factor driving microbiome composition, bacterial signatures and functions such as enrichment with Gram-negative oral-associated bacteria and microbial lactic acid production were associated with the early stages of the esophageal adenocarcinoma cascade." | 3.88 | Signatures within the esophageal microbiome are associated with host genetics, age, and disease. ( Castaño-Rodríguez, N; Deshpande, NP; Kaakoush, NO; Riordan, SM; Wilkins, MR, 2018) |
" In this work CUR-NPs (curcumin-loaded lipid-polymer-lecithin hybrid nanoparticles) were synthesized and functionalized with ribonucleic acid (RNA) Aptamers (Apts) against epithelial cell adhesion molecule (EpCAM) for targeted delivery to colorectal adenocarcinoma cells." | 3.80 | Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells. ( Duan, W; Li, L; Li, Q; Lin, J; Liu, K; Shigdar, S; Xiang, D; Yang, W, 2014) |
" Mutations in the tyrosine kinase epidermal growth factor receptor (EGFR) induce oncogenic addiction in lung adenocarcinoma (LAD)." | 3.80 | Epidermal growth factor receptor (EGFR) signaling regulates global metabolic pathways in EGFR-mutated lung adenocarcinoma. ( Esumi, H; Makinoshima, H; Matsumoto, S; Owada, S; Takita, M; Tsuchihara, K; Yagishita, A, 2014) |
" The present study demonstrates that chitosan (CS)-modified PLGA NSs (CS-PLGA NSs) are preferentially taken up by human lung adenocarcinoma cells (A549)." | 3.75 | Improved cellular uptake of chitosan-modified PLGA nanospheres by A549 cells. ( Hirashima, N; Kawashima, Y; Sakai, T; Tahara, K; Takeuchi, H; Yamamoto, H, 2009) |
" However, due to its minimal water solubility, it is necessary to prepare an optimal nano-sized vehicle to overcome the low bioavailability issue." | 1.72 | Design and Development of a New Type of Hybrid PLGA/Lipid Nanoparticle as an Ursolic Acid Delivery System against Pancreatic Ductal Adenocarcinoma Cells. ( Gubernator, J; Jaromin, A; Markowski, A; Migdał, P; Olczak, E; Pawlik, K; Zaremba-Czogalla, M; Zygmunt, A, 2022) |
"Previous studies have shown that cervical cancer cells display markers of aerobic glycolysis, indicating that these tumors are likely to secrete lactate." | 1.51 | Lactate secreted by cervical cancer cells modulates macrophage phenotype. ( Alvarez, KLF; Baracat, EC; Boccardo, E; Carvalho, JP; Lepique, AP; Lorenzi, NP; Margarido, PFR; Rossetti, RAM; Stone, SC; Tacla, M; Yokochi, K, 2019) |
"In the treatment of lung adenocarcinoma, targeting PFKFB3 would be a promising therapeutic strategy." | 1.48 | Expression of PFKFB3 and Ki67 in lung adenocarcinomas and targeting PFKFB3 as a therapeutic strategy. ( Ke, H; Li, X; Liu, J; Liu, Y; Qian, L; Tian, W; Yao, C; Zhang, J, 2018) |
"The two main histological variants, squamous cell carcinomas (SCC) and adenocarcinomas (AC), resemble the cell morphology of exocervix and endocervix, respectively." | 1.43 | STAT3:FOXM1 and MCT1 drive uterine cervix carcinoma fitness to a lactate-rich microenvironment. ( Dias, S; Domingues, G; Felix, A; Ferreira, J; Goncalves, LG; Lam, EW; Maximo, V; Serpa, J; Silva, F; Silva, LS, 2016) |
"Metabolic profiles of human colon cancer cells have been extensively studied, but comparison with non-tumour counterparts has been neglected." | 1.40 | Validation of NCM460 cell model as control in antitumor strategies targeting colon adenocarcinoma metabolic reprogramming: trichostatin A as a case study. ( Alcarraz-Vizán, G; Cascante, M; Moyer, MP; Sánchez-Tena, S, 2014) |
") Thus, overall results suggest that nano-encapsulation of PD (NPD) increases drug bioavailability and thereby has a better chemo-preventive action against lung cancer in vivo and on A549 cells in vitro than that of PD." | 1.38 | Poly (lactide-co-glycolide) encapsulated extract of Phytolacca decandra demonstrates better intervention against induced lung adenocarcinoma in mice and on A549 cells. ( Bhadra, K; Das, J; Das, S; Khuda-Bukhsh, AR; Samadder, A, 2012) |
"The purpose of this work was to assess synergistic inhibitory responses of a novel chemopreventive combination regimen of drugs namely, aspirin in combination with calcium and folic acid on two human colon cancer cell lines, HT-29 and SW-480." | 1.36 | Nanoparticulate delivery of novel drug combination regimens for the chemoprevention of colon cancer. ( Chaudhary, A; Kanthamneni, N; Prabhu, S; Wang, J, 2010) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (6.45) | 18.7374 |
1990's | 4 (6.45) | 18.2507 |
2000's | 12 (19.35) | 29.6817 |
2010's | 33 (53.23) | 24.3611 |
2020's | 9 (14.52) | 2.80 |
Authors | Studies |
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Govindarasu, M | 1 |
Abirami, P | 1 |
Alharthi, SS | 1 |
Thiruvengadam, M | 1 |
Rajakumar, G | 1 |
Vaiyapuri, M | 1 |
Mai, S | 1 |
Liang, L | 1 |
Mai, G | 1 |
Liu, X | 1 |
Diao, D | 1 |
Cai, R | 1 |
Liu, L | 1 |
Chen, Y | 3 |
Hu, L | 1 |
Lin, H | 1 |
Yu, H | 1 |
You, J | 1 |
Markowski, A | 1 |
Jaromin, A | 1 |
Migdał, P | 1 |
Olczak, E | 1 |
Zygmunt, A | 1 |
Zaremba-Czogalla, M | 1 |
Pawlik, K | 1 |
Gubernator, J | 1 |
Chen, Z | 1 |
Song, Y | 1 |
Li, P | 2 |
Gao, W | 2 |
Cheng, S | 1 |
Li, Z | 1 |
Bai, X | 1 |
Feng, J | 1 |
Su, R | 1 |
Song, L | 1 |
Yang, H | 1 |
Zhan, X | 1 |
Xia, X | 1 |
Lü, X | 1 |
Shi, C | 1 |
Wang, M | 1 |
He, T | 1 |
Meng, D | 1 |
Lv, W | 1 |
Ye, J | 1 |
Cheng, L | 1 |
Hu, J | 1 |
Donisi, G | 1 |
Barbagallo, M | 1 |
Capretti, G | 1 |
Nappo, G | 1 |
Takis, PG | 1 |
Zerbi, A | 1 |
Marchesi, F | 1 |
Cortese, N | 1 |
Markovic, S | 1 |
Roussel, T | 1 |
Agemy, L | 1 |
Sasson, K | 1 |
Preise, D | 1 |
Scherz, A | 1 |
Frydman, L | 1 |
Phua, LC | 1 |
Goh, S | 1 |
Tai, DWM | 1 |
Leow, WQ | 1 |
Alkaff, SMF | 1 |
Chan, CY | 1 |
Kam, JH | 1 |
Lim, TKH | 1 |
Chan, ECY | 1 |
Li, X | 1 |
Liu, J | 1 |
Qian, L | 1 |
Ke, H | 1 |
Yao, C | 1 |
Tian, W | 1 |
Liu, Y | 1 |
Zhang, J | 1 |
Sahin, A | 1 |
Spiroux, F | 1 |
Guedon, I | 1 |
Arslan, FB | 1 |
Sarcan, ET | 1 |
Ozkan, T | 1 |
Colak, N | 1 |
Yuksel, S | 1 |
Ozdemir, S | 1 |
Ozdemir, B | 1 |
Akbas, S | 1 |
Ultav, G | 1 |
Aktas, Y | 1 |
Capan, Y | 1 |
Milshteyn, E | 1 |
von Morze, C | 1 |
Gordon, JW | 1 |
Zhu, Z | 1 |
Larson, PEZ | 1 |
Vigneron, DB | 3 |
Jiang, W | 1 |
Wang, H | 1 |
Cui, Y | 1 |
Lei, Y | 1 |
Wang, Y | 2 |
Xu, D | 1 |
Jiang, N | 1 |
Sun, Y | 1 |
Zhang, Y | 1 |
Cao, J | 1 |
Ke, Z | 1 |
Deshpande, NP | 1 |
Riordan, SM | 1 |
Castaño-Rodríguez, N | 1 |
Wilkins, MR | 1 |
Kaakoush, NO | 1 |
Stone, SC | 1 |
Rossetti, RAM | 1 |
Alvarez, KLF | 1 |
Carvalho, JP | 1 |
Margarido, PFR | 1 |
Baracat, EC | 1 |
Tacla, M | 1 |
Boccardo, E | 1 |
Yokochi, K | 1 |
Lorenzi, NP | 1 |
Lepique, AP | 1 |
Xing, Y | 1 |
Reed, GD | 1 |
Pauly, JM | 2 |
Kerr, AB | 2 |
Larson, PE | 2 |
He, X | 1 |
Mishchuk, DO | 1 |
Shah, J | 1 |
Weimer, BC | 1 |
Slupsky, CM | 1 |
Alcarraz-Vizán, G | 1 |
Sánchez-Tena, S | 1 |
Moyer, MP | 1 |
Cascante, M | 1 |
Chen, L | 1 |
Zeng, F | 1 |
Kong, LX | 1 |
Li, L | 1 |
Xiang, D | 1 |
Shigdar, S | 1 |
Yang, W | 1 |
Li, Q | 1 |
Lin, J | 1 |
Liu, K | 1 |
Duan, W | 1 |
An, YJ | 1 |
Cho, HR | 1 |
Kim, TM | 1 |
Keam, B | 1 |
Kim, JW | 1 |
Wen, H | 1 |
Park, CK | 1 |
Lee, SH | 1 |
Im, SA | 1 |
Kim, JE | 1 |
Choi, SH | 1 |
Park, S | 1 |
Makinoshima, H | 2 |
Takita, M | 2 |
Matsumoto, S | 2 |
Yagishita, A | 1 |
Owada, S | 1 |
Esumi, H | 2 |
Tsuchihara, K | 2 |
Jiang, L | 1 |
Wang, R | 1 |
Lu, M | 1 |
Zhang, Q | 1 |
Zhou, Y | 1 |
Wang, Z | 1 |
Lu, G | 1 |
Liang, P | 1 |
Ran, H | 1 |
Chen, H | 1 |
Zheng, Y | 1 |
Tsujimoto, H | 1 |
Morimoto, Y | 1 |
Takahata, R | 1 |
Nomura, S | 1 |
Yoshida, K | 2 |
Hiraki, S | 1 |
Horiguchi, H | 1 |
Miyazaki, H | 1 |
Ono, S | 1 |
Saito, D | 1 |
Hara, I | 1 |
Ozeki, E | 1 |
Yamamoto, J | 1 |
Hase, K | 1 |
Saruwatari, K | 1 |
Umemura, S | 1 |
Obata, Y | 1 |
Ishii, G | 1 |
Sugiyama, E | 1 |
Ochiai, A | 1 |
Abe, R | 1 |
Goto, K | 1 |
Essa, S | 1 |
Daoud, J | 1 |
Lafleur, M | 1 |
Martel, S | 1 |
Tabrizian, M | 1 |
Vlachostergios, PJ | 1 |
Oikonomou, KG | 1 |
Gibilaro, E | 1 |
Apergis, G | 1 |
Silva, LS | 1 |
Goncalves, LG | 1 |
Silva, F | 1 |
Domingues, G | 1 |
Maximo, V | 1 |
Ferreira, J | 1 |
Lam, EW | 1 |
Dias, S | 1 |
Felix, A | 1 |
Serpa, J | 1 |
Bernacchioni, C | 1 |
Ghini, V | 1 |
Cencetti, F | 1 |
Japtok, L | 1 |
Donati, C | 1 |
Bruni, P | 1 |
Turano, P | 1 |
Albers, MJ | 1 |
Bok, R | 1 |
Chen, AP | 1 |
Cunningham, CH | 1 |
Zierhut, ML | 1 |
Zhang, VY | 1 |
Kohler, SJ | 1 |
Tropp, J | 1 |
Hurd, RE | 1 |
Yen, YF | 1 |
Nelson, SJ | 1 |
Kurhanewicz, J | 1 |
Patil, Y | 1 |
Sadhukha, T | 1 |
Ma, L | 1 |
Panyam, J | 1 |
Tahara, K | 2 |
Sakai, T | 1 |
Yamamoto, H | 2 |
Takeuchi, H | 1 |
Hirashima, N | 1 |
Kawashima, Y | 2 |
Wartenberg, M | 1 |
Richter, M | 1 |
Datchev, A | 1 |
Günther, S | 1 |
Milosevic, N | 1 |
Bekhite, MM | 1 |
Figulla, HR | 1 |
Aran, JM | 1 |
Pétriz, J | 1 |
Sauer, H | 1 |
Kanthamneni, N | 1 |
Chaudhary, A | 1 |
Wang, J | 1 |
Prabhu, S | 1 |
Mishra, D | 1 |
Kang, HC | 1 |
Bae, YH | 1 |
Şengel-Türk, CT | 1 |
Hasçiçek, C | 1 |
Dogan, AL | 1 |
Esendagli, G | 1 |
Guc, D | 1 |
Gönül, N | 1 |
Zhang, L | 1 |
Webster, TJ | 1 |
Dauchy, RT | 1 |
Dauchy, EM | 1 |
Mao, L | 1 |
Belancio, VP | 1 |
Hill, SM | 1 |
Blask, DE | 1 |
Mueller, M | 1 |
Reichardt, W | 1 |
Koerner, J | 1 |
Groettrup, M | 1 |
Das, J | 1 |
Das, S | 1 |
Samadder, A | 1 |
Bhadra, K | 1 |
Khuda-Bukhsh, AR | 1 |
Hur, H | 1 |
Xuan, Y | 1 |
Kim, YB | 1 |
Lee, G | 1 |
Shim, W | 1 |
Yun, J | 1 |
Ham, IH | 1 |
Han, SU | 1 |
Swisher, CL | 1 |
Jiménez, B | 1 |
Mirnezami, R | 1 |
Kinross, J | 1 |
Cloarec, O | 1 |
Keun, HC | 1 |
Holmes, E | 1 |
Goldin, RD | 1 |
Ziprin, P | 1 |
Darzi, A | 1 |
Nicholson, JK | 1 |
Zhang, GZ | 1 |
Huang, GJ | 1 |
Li, WL | 1 |
Wu, GM | 1 |
Qian, GS | 1 |
Walenta, S | 2 |
Chau, TV | 1 |
Schroeder, T | 1 |
Lehr, HA | 1 |
Kunz-Schughart, LA | 1 |
Fuerst, A | 1 |
Mueller-Klieser, W | 1 |
RAMKISSOON, RA | 1 |
CHAMBERLAIN, NO | 1 |
BAKER, EL | 1 |
JENNINGS, ER | 1 |
Alrefai, WA | 1 |
Tyagi, S | 1 |
Gill, R | 1 |
Saksena, S | 1 |
Hadjiagapiou, C | 1 |
Mansour, F | 1 |
Ramaswamy, K | 1 |
Dudeja, PK | 1 |
Guo, J | 1 |
Higashi, K | 1 |
Yokota, H | 1 |
Nagao, Y | 1 |
Ueda, Y | 1 |
Kodama, Y | 1 |
Oguchi, M | 1 |
Taki, S | 1 |
Tonami, H | 1 |
Yamamoto, I | 1 |
VANNOTTI, A | 1 |
NEUKOMM, S | 1 |
Koukourakis, MI | 1 |
Giatromanolaki, A | 1 |
Harris, AL | 1 |
Sivridis, E | 1 |
Son, HJ | 1 |
Kim, JS | 1 |
Tamulevicius, P | 1 |
Streffer, C | 1 |
Waki, A | 1 |
Fujibayashi, Y | 1 |
Sadato, N | 1 |
Tsuchida, T | 1 |
Ishii, Y | 1 |
Yokoyama, A | 1 |
Yonekura, Y | 1 |
Wang, F | 1 |
Larsson, J | 1 |
Adrian, TE | 1 |
Gasslander, T | 1 |
Permert, J | 1 |
Parnaud, G | 1 |
Corpet, DE | 1 |
Gamet-Payrastre, L | 1 |
Sabel, MS | 1 |
Hill, H | 1 |
Jong, YS | 1 |
Mathiowitz, E | 1 |
Bankert, RB | 1 |
Egilmez, NK | 1 |
Morello, E | 1 |
Dernell, WS | 1 |
Kuntz, CA | 1 |
LaRue, SM | 1 |
Lafferty, M | 1 |
Nelson, A | 1 |
Brekke, JH | 1 |
Mallinckrodt, CH | 1 |
Withrow, SJ | 1 |
Manning, MC | 1 |
Wiedemann, G | 1 |
Müller-Klieser, W | 1 |
Schleinkofer, L | 1 |
Wood, WG | 1 |
Tisdale, MJ | 1 |
Brennan, RA | 1 |
Takahashi, M | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Hyperpolarized 13-C Pyruvate MRI Surveillance of Multiple Cancers[NCT05697406] | Phase 1/Phase 2 | 25 participants (Anticipated) | Interventional | 2024-02-01 | Not yet recruiting | ||
A Phase 1 Ascending-dose Study to Assess the Safety and Tolerability and Imaging Potential of Hyperpolarized Pyruvate (13C) Injection in Subjects With Prostate Cancer[NCT01229618] | Phase 1 | 31 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
1 trial available for lactic acid and Adenocarcinoma
Article | Year |
---|---|
Elevated lactic acid is a negative prognostic factor in metastatic lung cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Large Cell; Carcinoma, Non-Sm | 2015 |
61 other studies available for lactic acid and Adenocarcinoma
Article | Year |
---|---|
Synthesis, physicochemical characterization, and in vitro evaluation of biodegradable PLGA nanoparticles entrapped to folic acid for targeted delivery of kaempferitrin.
Topics: Adenocarcinoma; Colonic Neoplasms; Drug Carriers; Folic Acid; Humans; Lactic Acid; Nanoparticles; Pa | 2022 |
Development and Validation of Lactate Metabolism-Related lncRNA Signature as a Prognostic Model for Lung Adenocarcinoma.
Topics: Adenocarcinoma; Biomarkers, Tumor; CD8-Positive T-Lymphocytes; Humans; Lactic Acid; Lung; Prognosis; | 2022 |
Serum metabolomic profiling for patients with adenocarcinoma of the esophagogastric junction.
Topics: Adenocarcinoma; Esophagogastric Junction; Glutamic Acid; Humans; Lactic Acid; Metabolomics; Stomach | 2022 |
Design and Development of a New Type of Hybrid PLGA/Lipid Nanoparticle as an Ursolic Acid Delivery System against Pancreatic Ductal Adenocarcinoma Cells.
Topics: Adenocarcinoma; Humans; Lactic Acid; Liposomes; Nanoparticles; Pancreatic Neoplasms; Particle Size; | 2022 |
GRIN2D knockdown suppresses the progression of lung adenocarcinoma by regulating the E2F signalling pathway.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Cell Proliferation; Gene Expression Regulation, Neoplastic; | 2023 |
The biochemical characteristics of viable but nonculturable state Yersinia enterocolitica induced by lactic acid stress and its presence in food systems.
Topics: Adenocarcinoma; Caco-2 Cells; Caffeine; Humans; Lactic Acid; Yersinia enterocolitica | 2023 |
BZW2 Modulates Lung Adenocarcinoma Progression through Glycolysis-Mediated IDH3G Lactylation Modification.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Cell Line, Tumor; Cell Proliferation; Gene Expressi | 2023 |
Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma.
Topics: Adenocarcinoma; Animals; Biomarkers, Tumor; Cell Line, Tumor; Extracellular Fluid; Glucose; Humans; | 2020 |
Deuterium MRSI characterizations of glucose metabolism in orthotopic pancreatic cancer mouse models.
Topics: Adenocarcinoma; Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Deuterium; Disease Models, | 2021 |
Metabolomic prediction of treatment outcome in pancreatic ductal adenocarcinoma patients receiving gemcitabine.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Biomarkers; Carcinoma, Pancreatic Ductal; Deo | 2018 |
Expression of PFKFB3 and Ki67 in lung adenocarcinomas and targeting PFKFB3 as a therapeutic strategy.
Topics: A549 Cells; Adenocarcinoma; Adenocarcinoma of Lung; Adult; Aged; Aged, 80 and over; Apoptosis; Bioma | 2018 |
Using PVA and TPGS as combined emulsifier in nanoprecipitation method improves characteristics and anticancer activity of ibuprofen loaded PLGA nanoparticles.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Breast Neoplasms; Caco-2 Cells; Chemistry, Pharmaceu | 2017 |
High spatiotemporal resolution bSSFP imaging of hyperpolarized [1-
Topics: Adenocarcinoma; Alanine; Animals; Carbon Isotopes; Image Processing, Computer-Assisted; Lactic Acid; | 2018 |
Polymer nanofiber-based microchips for EGFR mutation analysis of circulating tumor cells in lung adenocarcinoma.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Base Sequence; Carcinoma, Non-Small-Cell Lung; Cell Count; C | 2018 |
Signatures within the esophageal microbiome are associated with host genetics, age, and disease.
Topics: Adenocarcinoma; Age Factors; Aged; Bacteria; Bacteriophages; DNA, Bacterial; DNA, Ribosomal; Esophag | 2018 |
Lactate secreted by cervical cancer cells modulates macrophage phenotype.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Cell Line, Tumor; Cocultur | 2019 |
Optimal variable flip angle schemes for dynamic acquisition of exchanging hyperpolarized substrates.
Topics: Adenocarcinoma; Algorithms; Animals; Biotransformation; Carbon Isotopes; Computer Simulation; Image | 2013 |
Cross-talk between E. coli strains and a human colorectal adenocarcinoma-derived cell line.
Topics: Adenocarcinoma; Caco-2 Cells; Cell Line, Tumor; Citric Acid Cycle; Coculture Techniques; Colorectal | 2013 |
Validation of NCM460 cell model as control in antitumor strategies targeting colon adenocarcinoma metabolic reprogramming: trichostatin A as a case study.
Topics: Adenocarcinoma; Antineoplastic Agents; Citric Acid Cycle; Colonic Neoplasms; Glucose; Glycolysis; Hi | 2014 |
Targeted delivery of 5-fluorouracil to HT-29 cells using high efficient folic acid-conjugated nanoparticles.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Biological Transport; Cell Survival; Colonic Neopla | 2015 |
Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells.
Topics: Adenocarcinoma; Animals; Antigens, Neoplasm; Antineoplastic Agents; Aptamers, Nucleotide; Cell Adhes | 2014 |
An NMR metabolomics approach for the diagnosis of leptomeningeal carcinomatosis in lung adenocarcinoma cancer patients.
Topics: Adenocarcinoma; Alanine; Area Under Curve; Biomarkers, Tumor; Case-Control Studies; Citric Acid; Cre | 2015 |
Epidermal growth factor receptor (EGFR) signaling regulates global metabolic pathways in EGFR-mutated lung adenocarcinoma.
Topics: Adenocarcinoma; Aspartate Carbamoyltransferase; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) | 2014 |
Injectable smart phase-transformation implants for highly efficient in vivo magnetic-hyperthermia regression of tumors.
Topics: Ablation Techniques; Adenocarcinoma; Animals; Humans; Hyperthermia, Induced; Lactic Acid; Magnetic F | 2014 |
Theranostic Photosensitive Nanoparticles for Lymph Node Metastasis of Gastric Cancer.
Topics: Adenocarcinoma; Animals; Apoptosis; Cell Proliferation; Coloring Agents; Drug Delivery Systems; Fluo | 2015 |
Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Aerobiosis; Cell Line, Tumor; Cell Proliferation; ErbB Recep | 2015 |
SN-38 active loading in poly(lactic-co-glycolic acid) nanoparticles and assessment of their anticancer properties on COLO-205 human colon adenocarcinoma cells.
Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Line, Tumor; Cell P | 2015 |
STAT3:FOXM1 and MCT1 drive uterine cervix carcinoma fitness to a lactate-rich microenvironment.
Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Cell Cycle Proteins; Cervix Uteri; Female; Forkhe | 2016 |
NMR metabolomics highlights sphingosine kinase-1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells.
Topics: Adenocarcinoma; Animals; Carbon Dioxide; Cell Cycle Proteins; Cell Line, Tumor; Female; Glucose; Glu | 2017 |
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.
Topics: Adenocarcinoma; Alanine; Animals; Biomarkers, Tumor; Carbon Isotopes; Disease Models, Animal; Lactic | 2008 |
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.
Topics: Adenocarcinoma; Alanine; Animals; Biomarkers, Tumor; Carbon Isotopes; Disease Models, Animal; Lactic | 2008 |
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.
Topics: Adenocarcinoma; Alanine; Animals; Biomarkers, Tumor; Carbon Isotopes; Disease Models, Animal; Lactic | 2008 |
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.
Topics: Adenocarcinoma; Alanine; Animals; Biomarkers, Tumor; Carbon Isotopes; Disease Models, Animal; Lactic | 2008 |
Nanoparticle-mediated simultaneous and targeted delivery of paclitaxel and tariquidar overcomes tumor drug resistance.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfam | 2009 |
Improved cellular uptake of chitosan-modified PLGA nanospheres by A549 cells.
Topics: Adenocarcinoma; Biological Transport, Active; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceut | 2009 |
Glycolytic pyruvate regulates P-Glycoprotein expression in multicellular tumor spheroids via modulation of the intracellular redox state.
Topics: Adenocarcinoma; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1 | 2010 |
Cellular uptake mechanisms and intracellular distributions of polysorbate 80-modified poly (D,L-lactide-co-glycolide) nanospheres for gene delivery.
Topics: Adenocarcinoma; Cell Line, Tumor; Clathrin; DNA; Endocytosis; Gene Transfer Techniques; Genetic Vect | 2010 |
Nanoparticulate delivery of novel drug combination regimens for the chemoprevention of colon cancer.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Calcium; Cell Line, Tumor; | 2010 |
Reconstitutable charged polymeric (PLGA)(2)-b-PEI micelles for gene therapeutics delivery.
Topics: Adenocarcinoma; Breast Neoplasms; Cell Line, Tumor; DNA; Female; Gene Transfer Techniques; Genetic T | 2011 |
Preparation and in vitro evaluation of meloxicam-loaded PLGA nanoparticles on HT-29 human colon adenocarcinoma cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Biological Transport; Cell Survival; Chemistry, Pharmaceutica | 2012 |
Poly-lactic-glycolic-acid surface nanotopographies selectively decrease breast adenocarcinoma cell functions.
Topics: Adenocarcinoma; Apoptosis; Breast; Breast Neoplasms; Cell Adhesion; Cell Count; Cell Line, Tumor; Ce | 2012 |
A new apparatus and surgical technique for the dual perfusion of human tumor xenografts in situ in nude rats.
Topics: Adenocarcinoma; Animals; Artificial Organs; Blood Glucose; Carbon Dioxide; Cell Proliferation; Colon | 2012 |
Coencapsulation of tumor lysate and CpG-ODN in PLGA-microspheres enables successful immunotherapy of prostate carcinoma in TRAMP mice.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; Cell Line; Drug Carriers; Humans; Immunization; Lac | 2012 |
Poly (lactide-co-glycolide) encapsulated extract of Phytolacca decandra demonstrates better intervention against induced lung adenocarcinoma in mice and on A549 cells.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antineoplastic Agents; Arsenites; bcl-2-Associated | 2012 |
Expression of pyruvate dehydrogenase kinase-1 in gastric cancer as a potential therapeutic target.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Aged; Antimetabolites, Antineoplastic; Blotting, Western; | 2013 |
A rapid method for direct detection of metabolic conversion and magnetization exchange with application to hyperpolarized substrates.
Topics: Adenocarcinoma; Algorithms; Animals; Electromagnetic Fields; Humans; Kinetics; L-Lactate Dehydrogena | 2012 |
1H HR-MAS NMR spectroscopy of tumor-induced local metabolic "field-effects" enables colorectal cancer staging and prognostication.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Amino Acids; Biomarkers, Tumor; Cell Transformation, | 2013 |
[Effect of co-inhibition of MCT1 gene and NHE1 gene on proliferation and growth of human lung adenocarcinoma cells].
Topics: Adenocarcinoma; Animals; Cell Cycle; Cell Division; Disease Models, Animal; DNA, Antisense; Humans; | 2002 |
Metabolic classification of human rectal adenocarcinomas: a novel guideline for clinical oncologists?
Topics: Adenocarcinoma; Adenosine Triphosphate; Aged; Aged, 80 and over; Biopsy; Female; Humans; Lactic Acid | 2003 |
DIAGNOSTIC SIGNIFICANCE OF URINARY LACTIC ACID DEHYDROGENASE.
Topics: Adenocarcinoma; Albuminuria; Carcinoma, Papillary; Carcinoma, Transitional Cell; Clinical Enzyme Tes | 1964 |
Regulation of butyrate uptake in Caco-2 cells by phorbol 12-myristate 13-acetate.
Topics: Adenocarcinoma; Butyric Acid; Caco-2 Cells; Carcinogens; Colonic Neoplasms; Drug Administration Sche | 2004 |
In vitro proton magnetic resonance spectroscopic lactate and choline measurements, 18F-FDG uptake, and prognosis in patients with lung adenocarcinoma.
Topics: Adenocarcinoma; Aged; Choline; Disease-Free Survival; Female; Fluorodeoxyglucose F18; Humans; Japan; | 2004 |
[Action of dehydrase of lactic acid on the growth of mammary adenocarcinoma of mice].
Topics: Adenocarcinoma; Animals; Lactic Acid; Mice; Neoplasms; Physiological Phenomena | 1950 |
Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma.
Topics: Adenocarcinoma; Cell Cycle Proteins; Cell Hypoxia; Cell Proliferation; Cell Survival; Colon; Colorec | 2006 |
Therapeutic efficacy of DNA-loaded PLGA microspheres in tumor-bearing mice.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Combined Modality Therap | 2007 |
Metabolic imaging in tumours by means of bioluminescence.
Topics: Adenocarcinoma; Adenosine Triphosphate; Animals; Carcinoma, Squamous Cell; Cell Death; Colorectal Ne | 1995 |
Effects of antitumor agents on 3H-2-deoxyglucose uptake in tumor cells and their relationship with the main targets of the antitumor agents.
Topics: 2,4-Dinitrophenol; Adenocarcinoma; Adenosine Triphosphate; Antineoplastic Agents; Cisplatin; Deoxygl | 1997 |
In vitro influences between pancreatic adenocarcinoma cells and pancreatic islets.
Topics: Adenocarcinoma; Animals; Cell Division; Coculture Techniques; Glucose; Humans; Insulin; Insulin Secr | 1998 |
Cytostatic effect of polyethylene glycol on human colonic adenocarcinoma cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Caco-2 Cells; Cell Differentiation; Cell Division; | 2001 |
Neoadjuvant therapy with interleukin-12-loaded polylactic acid microspheres reduces local recurrence and distant metastases.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; Immunity; Injections, Intralesional; Interleukin-12 | 2001 |
Evaluation of cisplatin in combination with a biologic response modifier in a murine mammary carcinoma model.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; Antineoplastic Agents; Bile; Cisplatin; Delayed-Act | 2002 |
Low light level in vitro monitoring of cellular and antigen-antibody reactions using a photon detection camera system--new perspectives for clinical diagnosis and research.
Topics: Adenocarcinoma; Adenosine Triphosphate; Animals; Antigen-Antibody Reactions; Blood Glucose; Cell Lin | 1990 |
Metabolic substrate utilization by a tumour cell line which induces cachexia in vivo.
Topics: Adenocarcinoma; Animals; Cachexia; Cell Line; Colonic Neoplasms; Glucose; Ketone Bodies; Lactates; L | 1986 |
[Administration of mitomycin-C with an inactivator].
Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Drug Therapy, Combination; Humans; Lactates; L | 1985 |