lactic acid has been researched along with Adenocarcinoma in 62 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Adenocarcinoma: A malignant epithelial tumor with a glandular organization.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Resistance to gemcitabine remains a key challenge in the treatment of pancreatic ductal adenocarcinoma (PDAC), necessitating the constant search for effective strategies for a priori prediction of clinical outcome." | 7.88 | Metabolomic prediction of treatment outcome in pancreatic ductal adenocarcinoma patients receiving gemcitabine. ( Alkaff, SMF; Chan, CY; Chan, ECY; Goh, S; Kam, JH; Leow, WQ; Lim, TKH; Phua, LC; Tai, DWM, 2018) |
| " In this work CUR-NPs (curcumin-loaded lipid-polymer-lecithin hybrid nanoparticles) were synthesized and functionalized with ribonucleic acid (RNA) Aptamers (Apts) against epithelial cell adhesion molecule (EpCAM) for targeted delivery to colorectal adenocarcinoma cells." | 7.80 | Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells. ( Duan, W; Li, L; Li, Q; Lin, J; Liu, K; Shigdar, S; Xiang, D; Yang, W, 2014) |
| " Mutations in the tyrosine kinase epidermal growth factor receptor (EGFR) induce oncogenic addiction in lung adenocarcinoma (LAD)." | 7.80 | Epidermal growth factor receptor (EGFR) signaling regulates global metabolic pathways in EGFR-mutated lung adenocarcinoma. ( Esumi, H; Makinoshima, H; Matsumoto, S; Owada, S; Takita, M; Tsuchihara, K; Yagishita, A, 2014) |
| " However, due to its minimal water solubility, it is necessary to prepare an optimal nano-sized vehicle to overcome the low bioavailability issue." | 5.72 | Design and Development of a New Type of Hybrid PLGA/Lipid Nanoparticle as an Ursolic Acid Delivery System against Pancreatic Ductal Adenocarcinoma Cells. ( Gubernator, J; Jaromin, A; Markowski, A; Migdał, P; Olczak, E; Pawlik, K; Zaremba-Czogalla, M; Zygmunt, A, 2022) |
| "Metabolic profiles of human colon cancer cells have been extensively studied, but comparison with non-tumour counterparts has been neglected." | 5.40 | Validation of NCM460 cell model as control in antitumor strategies targeting colon adenocarcinoma metabolic reprogramming: trichostatin A as a case study. ( Alcarraz-Vizán, G; Cascante, M; Moyer, MP; Sánchez-Tena, S, 2014) |
| "Resistance to gemcitabine remains a key challenge in the treatment of pancreatic ductal adenocarcinoma (PDAC), necessitating the constant search for effective strategies for a priori prediction of clinical outcome." | 3.88 | Metabolomic prediction of treatment outcome in pancreatic ductal adenocarcinoma patients receiving gemcitabine. ( Alkaff, SMF; Chan, CY; Chan, ECY; Goh, S; Kam, JH; Leow, WQ; Lim, TKH; Phua, LC; Tai, DWM, 2018) |
| " While age was found to be a significant factor driving microbiome composition, bacterial signatures and functions such as enrichment with Gram-negative oral-associated bacteria and microbial lactic acid production were associated with the early stages of the esophageal adenocarcinoma cascade." | 3.88 | Signatures within the esophageal microbiome are associated with host genetics, age, and disease. ( Castaño-Rodríguez, N; Deshpande, NP; Kaakoush, NO; Riordan, SM; Wilkins, MR, 2018) |
| " In this work CUR-NPs (curcumin-loaded lipid-polymer-lecithin hybrid nanoparticles) were synthesized and functionalized with ribonucleic acid (RNA) Aptamers (Apts) against epithelial cell adhesion molecule (EpCAM) for targeted delivery to colorectal adenocarcinoma cells." | 3.80 | Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells. ( Duan, W; Li, L; Li, Q; Lin, J; Liu, K; Shigdar, S; Xiang, D; Yang, W, 2014) |
| " Mutations in the tyrosine kinase epidermal growth factor receptor (EGFR) induce oncogenic addiction in lung adenocarcinoma (LAD)." | 3.80 | Epidermal growth factor receptor (EGFR) signaling regulates global metabolic pathways in EGFR-mutated lung adenocarcinoma. ( Esumi, H; Makinoshima, H; Matsumoto, S; Owada, S; Takita, M; Tsuchihara, K; Yagishita, A, 2014) |
| " The present study demonstrates that chitosan (CS)-modified PLGA NSs (CS-PLGA NSs) are preferentially taken up by human lung adenocarcinoma cells (A549)." | 3.75 | Improved cellular uptake of chitosan-modified PLGA nanospheres by A549 cells. ( Hirashima, N; Kawashima, Y; Sakai, T; Tahara, K; Takeuchi, H; Yamamoto, H, 2009) |
| " However, due to its minimal water solubility, it is necessary to prepare an optimal nano-sized vehicle to overcome the low bioavailability issue." | 1.72 | Design and Development of a New Type of Hybrid PLGA/Lipid Nanoparticle as an Ursolic Acid Delivery System against Pancreatic Ductal Adenocarcinoma Cells. ( Gubernator, J; Jaromin, A; Markowski, A; Migdał, P; Olczak, E; Pawlik, K; Zaremba-Czogalla, M; Zygmunt, A, 2022) |
| "Previous studies have shown that cervical cancer cells display markers of aerobic glycolysis, indicating that these tumors are likely to secrete lactate." | 1.51 | Lactate secreted by cervical cancer cells modulates macrophage phenotype. ( Alvarez, KLF; Baracat, EC; Boccardo, E; Carvalho, JP; Lepique, AP; Lorenzi, NP; Margarido, PFR; Rossetti, RAM; Stone, SC; Tacla, M; Yokochi, K, 2019) |
| "In the treatment of lung adenocarcinoma, targeting PFKFB3 would be a promising therapeutic strategy." | 1.48 | Expression of PFKFB3 and Ki67 in lung adenocarcinomas and targeting PFKFB3 as a therapeutic strategy. ( Ke, H; Li, X; Liu, J; Liu, Y; Qian, L; Tian, W; Yao, C; Zhang, J, 2018) |
| "The two main histological variants, squamous cell carcinomas (SCC) and adenocarcinomas (AC), resemble the cell morphology of exocervix and endocervix, respectively." | 1.43 | STAT3:FOXM1 and MCT1 drive uterine cervix carcinoma fitness to a lactate-rich microenvironment. ( Dias, S; Domingues, G; Felix, A; Ferreira, J; Goncalves, LG; Lam, EW; Maximo, V; Serpa, J; Silva, F; Silva, LS, 2016) |
| "Metabolic profiles of human colon cancer cells have been extensively studied, but comparison with non-tumour counterparts has been neglected." | 1.40 | Validation of NCM460 cell model as control in antitumor strategies targeting colon adenocarcinoma metabolic reprogramming: trichostatin A as a case study. ( Alcarraz-Vizán, G; Cascante, M; Moyer, MP; Sánchez-Tena, S, 2014) |
| ") Thus, overall results suggest that nano-encapsulation of PD (NPD) increases drug bioavailability and thereby has a better chemo-preventive action against lung cancer in vivo and on A549 cells in vitro than that of PD." | 1.38 | Poly (lactide-co-glycolide) encapsulated extract of Phytolacca decandra demonstrates better intervention against induced lung adenocarcinoma in mice and on A549 cells. ( Bhadra, K; Das, J; Das, S; Khuda-Bukhsh, AR; Samadder, A, 2012) |
| "The purpose of this work was to assess synergistic inhibitory responses of a novel chemopreventive combination regimen of drugs namely, aspirin in combination with calcium and folic acid on two human colon cancer cell lines, HT-29 and SW-480." | 1.36 | Nanoparticulate delivery of novel drug combination regimens for the chemoprevention of colon cancer. ( Chaudhary, A; Kanthamneni, N; Prabhu, S; Wang, J, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (6.45) | 18.7374 |
| 1990's | 4 (6.45) | 18.2507 |
| 2000's | 12 (19.35) | 29.6817 |
| 2010's | 33 (53.23) | 24.3611 |
| 2020's | 9 (14.52) | 2.80 |
| Authors | Studies |
|---|---|
| Govindarasu, M | 1 |
| Abirami, P | 1 |
| Alharthi, SS | 1 |
| Thiruvengadam, M | 1 |
| Rajakumar, G | 1 |
| Vaiyapuri, M | 1 |
| Mai, S | 1 |
| Liang, L | 1 |
| Mai, G | 1 |
| Liu, X | 1 |
| Diao, D | 1 |
| Cai, R | 1 |
| Liu, L | 1 |
| Chen, Y | 3 |
| Hu, L | 1 |
| Lin, H | 1 |
| Yu, H | 1 |
| You, J | 1 |
| Markowski, A | 1 |
| Jaromin, A | 1 |
| Migdał, P | 1 |
| Olczak, E | 1 |
| Zygmunt, A | 1 |
| Zaremba-Czogalla, M | 1 |
| Pawlik, K | 1 |
| Gubernator, J | 1 |
| Chen, Z | 1 |
| Song, Y | 1 |
| Li, P | 2 |
| Gao, W | 2 |
| Cheng, S | 1 |
| Li, Z | 1 |
| Bai, X | 1 |
| Feng, J | 1 |
| Su, R | 1 |
| Song, L | 1 |
| Yang, H | 1 |
| Zhan, X | 1 |
| Xia, X | 1 |
| Lü, X | 1 |
| Shi, C | 1 |
| Wang, M | 1 |
| He, T | 1 |
| Meng, D | 1 |
| Lv, W | 1 |
| Ye, J | 1 |
| Cheng, L | 1 |
| Hu, J | 1 |
| Donisi, G | 1 |
| Barbagallo, M | 1 |
| Capretti, G | 1 |
| Nappo, G | 1 |
| Takis, PG | 1 |
| Zerbi, A | 1 |
| Marchesi, F | 1 |
| Cortese, N | 1 |
| Markovic, S | 1 |
| Roussel, T | 1 |
| Agemy, L | 1 |
| Sasson, K | 1 |
| Preise, D | 1 |
| Scherz, A | 1 |
| Frydman, L | 1 |
| Phua, LC | 1 |
| Goh, S | 1 |
| Tai, DWM | 1 |
| Leow, WQ | 1 |
| Alkaff, SMF | 1 |
| Chan, CY | 1 |
| Kam, JH | 1 |
| Lim, TKH | 1 |
| Chan, ECY | 1 |
| Li, X | 1 |
| Liu, J | 1 |
| Qian, L | 1 |
| Ke, H | 1 |
| Yao, C | 1 |
| Tian, W | 1 |
| Liu, Y | 1 |
| Zhang, J | 1 |
| Sahin, A | 1 |
| Spiroux, F | 1 |
| Guedon, I | 1 |
| Arslan, FB | 1 |
| Sarcan, ET | 1 |
| Ozkan, T | 1 |
| Colak, N | 1 |
| Yuksel, S | 1 |
| Ozdemir, S | 1 |
| Ozdemir, B | 1 |
| Akbas, S | 1 |
| Ultav, G | 1 |
| Aktas, Y | 1 |
| Capan, Y | 1 |
| Milshteyn, E | 1 |
| von Morze, C | 1 |
| Gordon, JW | 1 |
| Zhu, Z | 1 |
| Larson, PEZ | 1 |
| Vigneron, DB | 3 |
| Jiang, W | 1 |
| Wang, H | 1 |
| Cui, Y | 1 |
| Lei, Y | 1 |
| Wang, Y | 2 |
| Xu, D | 1 |
| Jiang, N | 1 |
| Sun, Y | 1 |
| Zhang, Y | 1 |
| Cao, J | 1 |
| Ke, Z | 1 |
| Deshpande, NP | 1 |
| Riordan, SM | 1 |
| Castaño-Rodríguez, N | 1 |
| Wilkins, MR | 1 |
| Kaakoush, NO | 1 |
| Stone, SC | 1 |
| Rossetti, RAM | 1 |
| Alvarez, KLF | 1 |
| Carvalho, JP | 1 |
| Margarido, PFR | 1 |
| Baracat, EC | 1 |
| Tacla, M | 1 |
| Boccardo, E | 1 |
| Yokochi, K | 1 |
| Lorenzi, NP | 1 |
| Lepique, AP | 1 |
| Xing, Y | 1 |
| Reed, GD | 1 |
| Pauly, JM | 2 |
| Kerr, AB | 2 |
| Larson, PE | 2 |
| He, X | 1 |
| Mishchuk, DO | 1 |
| Shah, J | 1 |
| Weimer, BC | 1 |
| Slupsky, CM | 1 |
| Alcarraz-Vizán, G | 1 |
| Sánchez-Tena, S | 1 |
| Moyer, MP | 1 |
| Cascante, M | 1 |
| Chen, L | 1 |
| Zeng, F | 1 |
| Kong, LX | 1 |
| Li, L | 1 |
| Xiang, D | 1 |
| Shigdar, S | 1 |
| Yang, W | 1 |
| Li, Q | 1 |
| Lin, J | 1 |
| Liu, K | 1 |
| Duan, W | 1 |
| An, YJ | 1 |
| Cho, HR | 1 |
| Kim, TM | 1 |
| Keam, B | 1 |
| Kim, JW | 1 |
| Wen, H | 1 |
| Park, CK | 1 |
| Lee, SH | 1 |
| Im, SA | 1 |
| Kim, JE | 1 |
| Choi, SH | 1 |
| Park, S | 1 |
| Makinoshima, H | 2 |
| Takita, M | 2 |
| Matsumoto, S | 2 |
| Yagishita, A | 1 |
| Owada, S | 1 |
| Esumi, H | 2 |
| Tsuchihara, K | 2 |
| Jiang, L | 1 |
| Wang, R | 1 |
| Lu, M | 1 |
| Zhang, Q | 1 |
| Zhou, Y | 1 |
| Wang, Z | 1 |
| Lu, G | 1 |
| Liang, P | 1 |
| Ran, H | 1 |
| Chen, H | 1 |
| Zheng, Y | 1 |
| Tsujimoto, H | 1 |
| Morimoto, Y | 1 |
| Takahata, R | 1 |
| Nomura, S | 1 |
| Yoshida, K | 2 |
| Hiraki, S | 1 |
| Horiguchi, H | 1 |
| Miyazaki, H | 1 |
| Ono, S | 1 |
| Saito, D | 1 |
| Hara, I | 1 |
| Ozeki, E | 1 |
| Yamamoto, J | 1 |
| Hase, K | 1 |
| Saruwatari, K | 1 |
| Umemura, S | 1 |
| Obata, Y | 1 |
| Ishii, G | 1 |
| Sugiyama, E | 1 |
| Ochiai, A | 1 |
| Abe, R | 1 |
| Goto, K | 1 |
| Essa, S | 1 |
| Daoud, J | 1 |
| Lafleur, M | 1 |
| Martel, S | 1 |
| Tabrizian, M | 1 |
| Vlachostergios, PJ | 1 |
| Oikonomou, KG | 1 |
| Gibilaro, E | 1 |
| Apergis, G | 1 |
| Silva, LS | 1 |
| Goncalves, LG | 1 |
| Silva, F | 1 |
| Domingues, G | 1 |
| Maximo, V | 1 |
| Ferreira, J | 1 |
| Lam, EW | 1 |
| Dias, S | 1 |
| Felix, A | 1 |
| Serpa, J | 1 |
| Bernacchioni, C | 1 |
| Ghini, V | 1 |
| Cencetti, F | 1 |
| Japtok, L | 1 |
| Donati, C | 1 |
| Bruni, P | 1 |
| Turano, P | 1 |
| Albers, MJ | 1 |
| Bok, R | 1 |
| Chen, AP | 1 |
| Cunningham, CH | 1 |
| Zierhut, ML | 1 |
| Zhang, VY | 1 |
| Kohler, SJ | 1 |
| Tropp, J | 1 |
| Hurd, RE | 1 |
| Yen, YF | 1 |
| Nelson, SJ | 1 |
| Kurhanewicz, J | 1 |
| Patil, Y | 1 |
| Sadhukha, T | 1 |
| Ma, L | 1 |
| Panyam, J | 1 |
| Tahara, K | 2 |
| Sakai, T | 1 |
| Yamamoto, H | 2 |
| Takeuchi, H | 1 |
| Hirashima, N | 1 |
| Kawashima, Y | 2 |
| Wartenberg, M | 1 |
| Richter, M | 1 |
| Datchev, A | 1 |
| Günther, S | 1 |
| Milosevic, N | 1 |
| Bekhite, MM | 1 |
| Figulla, HR | 1 |
| Aran, JM | 1 |
| Pétriz, J | 1 |
| Sauer, H | 1 |
| Kanthamneni, N | 1 |
| Chaudhary, A | 1 |
| Wang, J | 1 |
| Prabhu, S | 1 |
| Mishra, D | 1 |
| Kang, HC | 1 |
| Bae, YH | 1 |
| Şengel-Türk, CT | 1 |
| Hasçiçek, C | 1 |
| Dogan, AL | 1 |
| Esendagli, G | 1 |
| Guc, D | 1 |
| Gönül, N | 1 |
| Zhang, L | 1 |
| Webster, TJ | 1 |
| Dauchy, RT | 1 |
| Dauchy, EM | 1 |
| Mao, L | 1 |
| Belancio, VP | 1 |
| Hill, SM | 1 |
| Blask, DE | 1 |
| Mueller, M | 1 |
| Reichardt, W | 1 |
| Koerner, J | 1 |
| Groettrup, M | 1 |
| Das, J | 1 |
| Das, S | 1 |
| Samadder, A | 1 |
| Bhadra, K | 1 |
| Khuda-Bukhsh, AR | 1 |
| Hur, H | 1 |
| Xuan, Y | 1 |
| Kim, YB | 1 |
| Lee, G | 1 |
| Shim, W | 1 |
| Yun, J | 1 |
| Ham, IH | 1 |
| Han, SU | 1 |
| Swisher, CL | 1 |
| Jiménez, B | 1 |
| Mirnezami, R | 1 |
| Kinross, J | 1 |
| Cloarec, O | 1 |
| Keun, HC | 1 |
| Holmes, E | 1 |
| Goldin, RD | 1 |
| Ziprin, P | 1 |
| Darzi, A | 1 |
| Nicholson, JK | 1 |
| Zhang, GZ | 1 |
| Huang, GJ | 1 |
| Li, WL | 1 |
| Wu, GM | 1 |
| Qian, GS | 1 |
| Walenta, S | 2 |
| Chau, TV | 1 |
| Schroeder, T | 1 |
| Lehr, HA | 1 |
| Kunz-Schughart, LA | 1 |
| Fuerst, A | 1 |
| Mueller-Klieser, W | 1 |
| RAMKISSOON, RA | 1 |
| CHAMBERLAIN, NO | 1 |
| BAKER, EL | 1 |
| JENNINGS, ER | 1 |
| Alrefai, WA | 1 |
| Tyagi, S | 1 |
| Gill, R | 1 |
| Saksena, S | 1 |
| Hadjiagapiou, C | 1 |
| Mansour, F | 1 |
| Ramaswamy, K | 1 |
| Dudeja, PK | 1 |
| Guo, J | 1 |
| Higashi, K | 1 |
| Yokota, H | 1 |
| Nagao, Y | 1 |
| Ueda, Y | 1 |
| Kodama, Y | 1 |
| Oguchi, M | 1 |
| Taki, S | 1 |
| Tonami, H | 1 |
| Yamamoto, I | 1 |
| VANNOTTI, A | 1 |
| NEUKOMM, S | 1 |
| Koukourakis, MI | 1 |
| Giatromanolaki, A | 1 |
| Harris, AL | 1 |
| Sivridis, E | 1 |
| Son, HJ | 1 |
| Kim, JS | 1 |
| Tamulevicius, P | 1 |
| Streffer, C | 1 |
| Waki, A | 1 |
| Fujibayashi, Y | 1 |
| Sadato, N | 1 |
| Tsuchida, T | 1 |
| Ishii, Y | 1 |
| Yokoyama, A | 1 |
| Yonekura, Y | 1 |
| Wang, F | 1 |
| Larsson, J | 1 |
| Adrian, TE | 1 |
| Gasslander, T | 1 |
| Permert, J | 1 |
| Parnaud, G | 1 |
| Corpet, DE | 1 |
| Gamet-Payrastre, L | 1 |
| Sabel, MS | 1 |
| Hill, H | 1 |
| Jong, YS | 1 |
| Mathiowitz, E | 1 |
| Bankert, RB | 1 |
| Egilmez, NK | 1 |
| Morello, E | 1 |
| Dernell, WS | 1 |
| Kuntz, CA | 1 |
| LaRue, SM | 1 |
| Lafferty, M | 1 |
| Nelson, A | 1 |
| Brekke, JH | 1 |
| Mallinckrodt, CH | 1 |
| Withrow, SJ | 1 |
| Manning, MC | 1 |
| Wiedemann, G | 1 |
| Müller-Klieser, W | 1 |
| Schleinkofer, L | 1 |
| Wood, WG | 1 |
| Tisdale, MJ | 1 |
| Brennan, RA | 1 |
| Takahashi, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hyperpolarized 13-C Pyruvate MRI Surveillance of Multiple Cancers[NCT05697406] | Phase 1/Phase 2 | 25 participants (Anticipated) | Interventional | 2024-02-01 | Not yet recruiting | ||
| A Phase 1 Ascending-dose Study to Assess the Safety and Tolerability and Imaging Potential of Hyperpolarized Pyruvate (13C) Injection in Subjects With Prostate Cancer[NCT01229618] | Phase 1 | 31 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for lactic acid and Adenocarcinoma
| Article | Year |
|---|---|
Elevated lactic acid is a negative prognostic factor in metastatic lung cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Large Cell; Carcinoma, Non-Sm | 2015 |
61 other studies available for lactic acid and Adenocarcinoma
| Article | Year |
|---|---|
Synthesis, physicochemical characterization, and in vitro evaluation of biodegradable PLGA nanoparticles entrapped to folic acid for targeted delivery of kaempferitrin.
Topics: Adenocarcinoma; Colonic Neoplasms; Drug Carriers; Folic Acid; Humans; Lactic Acid; Nanoparticles; Pa | 2022 |
Development and Validation of Lactate Metabolism-Related lncRNA Signature as a Prognostic Model for Lung Adenocarcinoma.
Topics: Adenocarcinoma; Biomarkers, Tumor; CD8-Positive T-Lymphocytes; Humans; Lactic Acid; Lung; Prognosis; | 2022 |
Serum metabolomic profiling for patients with adenocarcinoma of the esophagogastric junction.
Topics: Adenocarcinoma; Esophagogastric Junction; Glutamic Acid; Humans; Lactic Acid; Metabolomics; Stomach | 2022 |
Design and Development of a New Type of Hybrid PLGA/Lipid Nanoparticle as an Ursolic Acid Delivery System against Pancreatic Ductal Adenocarcinoma Cells.
Topics: Adenocarcinoma; Humans; Lactic Acid; Liposomes; Nanoparticles; Pancreatic Neoplasms; Particle Size; | 2022 |
GRIN2D knockdown suppresses the progression of lung adenocarcinoma by regulating the E2F signalling pathway.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Cell Proliferation; Gene Expression Regulation, Neoplastic; | 2023 |
The biochemical characteristics of viable but nonculturable state Yersinia enterocolitica induced by lactic acid stress and its presence in food systems.
Topics: Adenocarcinoma; Caco-2 Cells; Caffeine; Humans; Lactic Acid; Yersinia enterocolitica | 2023 |
BZW2 Modulates Lung Adenocarcinoma Progression through Glycolysis-Mediated IDH3G Lactylation Modification.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Cell Line, Tumor; Cell Proliferation; Gene Expressi | 2023 |
Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma.
Topics: Adenocarcinoma; Animals; Biomarkers, Tumor; Cell Line, Tumor; Extracellular Fluid; Glucose; Humans; | 2020 |
Deuterium MRSI characterizations of glucose metabolism in orthotopic pancreatic cancer mouse models.
Topics: Adenocarcinoma; Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Deuterium; Disease Models, | 2021 |
Metabolomic prediction of treatment outcome in pancreatic ductal adenocarcinoma patients receiving gemcitabine.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Biomarkers; Carcinoma, Pancreatic Ductal; Deo | 2018 |
Expression of PFKFB3 and Ki67 in lung adenocarcinomas and targeting PFKFB3 as a therapeutic strategy.
Topics: A549 Cells; Adenocarcinoma; Adenocarcinoma of Lung; Adult; Aged; Aged, 80 and over; Apoptosis; Bioma | 2018 |
Using PVA and TPGS as combined emulsifier in nanoprecipitation method improves characteristics and anticancer activity of ibuprofen loaded PLGA nanoparticles.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Breast Neoplasms; Caco-2 Cells; Chemistry, Pharmaceu | 2017 |
High spatiotemporal resolution bSSFP imaging of hyperpolarized [1-
Topics: Adenocarcinoma; Alanine; Animals; Carbon Isotopes; Image Processing, Computer-Assisted; Lactic Acid; | 2018 |
Polymer nanofiber-based microchips for EGFR mutation analysis of circulating tumor cells in lung adenocarcinoma.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Base Sequence; Carcinoma, Non-Small-Cell Lung; Cell Count; C | 2018 |
Signatures within the esophageal microbiome are associated with host genetics, age, and disease.
Topics: Adenocarcinoma; Age Factors; Aged; Bacteria; Bacteriophages; DNA, Bacterial; DNA, Ribosomal; Esophag | 2018 |
Lactate secreted by cervical cancer cells modulates macrophage phenotype.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Cell Line, Tumor; Cocultur | 2019 |
Optimal variable flip angle schemes for dynamic acquisition of exchanging hyperpolarized substrates.
Topics: Adenocarcinoma; Algorithms; Animals; Biotransformation; Carbon Isotopes; Computer Simulation; Image | 2013 |
Cross-talk between E. coli strains and a human colorectal adenocarcinoma-derived cell line.
Topics: Adenocarcinoma; Caco-2 Cells; Cell Line, Tumor; Citric Acid Cycle; Coculture Techniques; Colorectal | 2013 |
Validation of NCM460 cell model as control in antitumor strategies targeting colon adenocarcinoma metabolic reprogramming: trichostatin A as a case study.
Topics: Adenocarcinoma; Antineoplastic Agents; Citric Acid Cycle; Colonic Neoplasms; Glucose; Glycolysis; Hi | 2014 |
Targeted delivery of 5-fluorouracil to HT-29 cells using high efficient folic acid-conjugated nanoparticles.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Biological Transport; Cell Survival; Colonic Neopla | 2015 |
Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells.
Topics: Adenocarcinoma; Animals; Antigens, Neoplasm; Antineoplastic Agents; Aptamers, Nucleotide; Cell Adhes | 2014 |
An NMR metabolomics approach for the diagnosis of leptomeningeal carcinomatosis in lung adenocarcinoma cancer patients.
Topics: Adenocarcinoma; Alanine; Area Under Curve; Biomarkers, Tumor; Case-Control Studies; Citric Acid; Cre | 2015 |
Epidermal growth factor receptor (EGFR) signaling regulates global metabolic pathways in EGFR-mutated lung adenocarcinoma.
Topics: Adenocarcinoma; Aspartate Carbamoyltransferase; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) | 2014 |
Injectable smart phase-transformation implants for highly efficient in vivo magnetic-hyperthermia regression of tumors.
Topics: Ablation Techniques; Adenocarcinoma; Animals; Humans; Hyperthermia, Induced; Lactic Acid; Magnetic F | 2014 |
Theranostic Photosensitive Nanoparticles for Lymph Node Metastasis of Gastric Cancer.
Topics: Adenocarcinoma; Animals; Apoptosis; Cell Proliferation; Coloring Agents; Drug Delivery Systems; Fluo | 2015 |
Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Aerobiosis; Cell Line, Tumor; Cell Proliferation; ErbB Recep | 2015 |
SN-38 active loading in poly(lactic-co-glycolic acid) nanoparticles and assessment of their anticancer properties on COLO-205 human colon adenocarcinoma cells.
Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Line, Tumor; Cell P | 2015 |
STAT3:FOXM1 and MCT1 drive uterine cervix carcinoma fitness to a lactate-rich microenvironment.
Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Cell Cycle Proteins; Cervix Uteri; Female; Forkhe | 2016 |
NMR metabolomics highlights sphingosine kinase-1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells.
Topics: Adenocarcinoma; Animals; Carbon Dioxide; Cell Cycle Proteins; Cell Line, Tumor; Female; Glucose; Glu | 2017 |
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.
Topics: Adenocarcinoma; Alanine; Animals; Biomarkers, Tumor; Carbon Isotopes; Disease Models, Animal; Lactic | 2008 |
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.
Topics: Adenocarcinoma; Alanine; Animals; Biomarkers, Tumor; Carbon Isotopes; Disease Models, Animal; Lactic | 2008 |
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.
Topics: Adenocarcinoma; Alanine; Animals; Biomarkers, Tumor; Carbon Isotopes; Disease Models, Animal; Lactic | 2008 |
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.
Topics: Adenocarcinoma; Alanine; Animals; Biomarkers, Tumor; Carbon Isotopes; Disease Models, Animal; Lactic | 2008 |
Nanoparticle-mediated simultaneous and targeted delivery of paclitaxel and tariquidar overcomes tumor drug resistance.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfam | 2009 |
Improved cellular uptake of chitosan-modified PLGA nanospheres by A549 cells.
Topics: Adenocarcinoma; Biological Transport, Active; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceut | 2009 |
Glycolytic pyruvate regulates P-Glycoprotein expression in multicellular tumor spheroids via modulation of the intracellular redox state.
Topics: Adenocarcinoma; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1 | 2010 |
Cellular uptake mechanisms and intracellular distributions of polysorbate 80-modified poly (D,L-lactide-co-glycolide) nanospheres for gene delivery.
Topics: Adenocarcinoma; Cell Line, Tumor; Clathrin; DNA; Endocytosis; Gene Transfer Techniques; Genetic Vect | 2010 |
Nanoparticulate delivery of novel drug combination regimens for the chemoprevention of colon cancer.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Calcium; Cell Line, Tumor; | 2010 |
Reconstitutable charged polymeric (PLGA)(2)-b-PEI micelles for gene therapeutics delivery.
Topics: Adenocarcinoma; Breast Neoplasms; Cell Line, Tumor; DNA; Female; Gene Transfer Techniques; Genetic T | 2011 |
Preparation and in vitro evaluation of meloxicam-loaded PLGA nanoparticles on HT-29 human colon adenocarcinoma cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Biological Transport; Cell Survival; Chemistry, Pharmaceutica | 2012 |
Poly-lactic-glycolic-acid surface nanotopographies selectively decrease breast adenocarcinoma cell functions.
Topics: Adenocarcinoma; Apoptosis; Breast; Breast Neoplasms; Cell Adhesion; Cell Count; Cell Line, Tumor; Ce | 2012 |
A new apparatus and surgical technique for the dual perfusion of human tumor xenografts in situ in nude rats.
Topics: Adenocarcinoma; Animals; Artificial Organs; Blood Glucose; Carbon Dioxide; Cell Proliferation; Colon | 2012 |
Coencapsulation of tumor lysate and CpG-ODN in PLGA-microspheres enables successful immunotherapy of prostate carcinoma in TRAMP mice.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; Cell Line; Drug Carriers; Humans; Immunization; Lac | 2012 |
Poly (lactide-co-glycolide) encapsulated extract of Phytolacca decandra demonstrates better intervention against induced lung adenocarcinoma in mice and on A549 cells.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antineoplastic Agents; Arsenites; bcl-2-Associated | 2012 |
Expression of pyruvate dehydrogenase kinase-1 in gastric cancer as a potential therapeutic target.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Aged; Antimetabolites, Antineoplastic; Blotting, Western; | 2013 |
A rapid method for direct detection of metabolic conversion and magnetization exchange with application to hyperpolarized substrates.
Topics: Adenocarcinoma; Algorithms; Animals; Electromagnetic Fields; Humans; Kinetics; L-Lactate Dehydrogena | 2012 |
1H HR-MAS NMR spectroscopy of tumor-induced local metabolic "field-effects" enables colorectal cancer staging and prognostication.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Amino Acids; Biomarkers, Tumor; Cell Transformation, | 2013 |
[Effect of co-inhibition of MCT1 gene and NHE1 gene on proliferation and growth of human lung adenocarcinoma cells].
Topics: Adenocarcinoma; Animals; Cell Cycle; Cell Division; Disease Models, Animal; DNA, Antisense; Humans; | 2002 |
Metabolic classification of human rectal adenocarcinomas: a novel guideline for clinical oncologists?
Topics: Adenocarcinoma; Adenosine Triphosphate; Aged; Aged, 80 and over; Biopsy; Female; Humans; Lactic Acid | 2003 |
DIAGNOSTIC SIGNIFICANCE OF URINARY LACTIC ACID DEHYDROGENASE.
Topics: Adenocarcinoma; Albuminuria; Carcinoma, Papillary; Carcinoma, Transitional Cell; Clinical Enzyme Tes | 1964 |
Regulation of butyrate uptake in Caco-2 cells by phorbol 12-myristate 13-acetate.
Topics: Adenocarcinoma; Butyric Acid; Caco-2 Cells; Carcinogens; Colonic Neoplasms; Drug Administration Sche | 2004 |
In vitro proton magnetic resonance spectroscopic lactate and choline measurements, 18F-FDG uptake, and prognosis in patients with lung adenocarcinoma.
Topics: Adenocarcinoma; Aged; Choline; Disease-Free Survival; Female; Fluorodeoxyglucose F18; Humans; Japan; | 2004 |
[Action of dehydrase of lactic acid on the growth of mammary adenocarcinoma of mice].
Topics: Adenocarcinoma; Animals; Lactic Acid; Mice; Neoplasms; Physiological Phenomena | 1950 |
Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma.
Topics: Adenocarcinoma; Cell Cycle Proteins; Cell Hypoxia; Cell Proliferation; Cell Survival; Colon; Colorec | 2006 |
Therapeutic efficacy of DNA-loaded PLGA microspheres in tumor-bearing mice.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Combined Modality Therap | 2007 |
Metabolic imaging in tumours by means of bioluminescence.
Topics: Adenocarcinoma; Adenosine Triphosphate; Animals; Carcinoma, Squamous Cell; Cell Death; Colorectal Ne | 1995 |
Effects of antitumor agents on 3H-2-deoxyglucose uptake in tumor cells and their relationship with the main targets of the antitumor agents.
Topics: 2,4-Dinitrophenol; Adenocarcinoma; Adenosine Triphosphate; Antineoplastic Agents; Cisplatin; Deoxygl | 1997 |
In vitro influences between pancreatic adenocarcinoma cells and pancreatic islets.
Topics: Adenocarcinoma; Animals; Cell Division; Coculture Techniques; Glucose; Humans; Insulin; Insulin Secr | 1998 |
Cytostatic effect of polyethylene glycol on human colonic adenocarcinoma cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Caco-2 Cells; Cell Differentiation; Cell Division; | 2001 |
Neoadjuvant therapy with interleukin-12-loaded polylactic acid microspheres reduces local recurrence and distant metastases.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; Immunity; Injections, Intralesional; Interleukin-12 | 2001 |
Evaluation of cisplatin in combination with a biologic response modifier in a murine mammary carcinoma model.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; Antineoplastic Agents; Bile; Cisplatin; Delayed-Act | 2002 |
Low light level in vitro monitoring of cellular and antigen-antibody reactions using a photon detection camera system--new perspectives for clinical diagnosis and research.
Topics: Adenocarcinoma; Adenosine Triphosphate; Animals; Antigen-Antibody Reactions; Blood Glucose; Cell Lin | 1990 |
Metabolic substrate utilization by a tumour cell line which induces cachexia in vivo.
Topics: Adenocarcinoma; Animals; Cachexia; Cell Line; Colonic Neoplasms; Glucose; Ketone Bodies; Lactates; L | 1986 |
[Administration of mitomycin-C with an inactivator].
Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Drug Therapy, Combination; Humans; Lactates; L | 1985 |