lactic acid has been researched along with Acute Hepatic Failure in 59 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Splenic rupture followed by lactic acidosis and hypoglycaemia should lead to suspicion of a cancer-mediated Warburg effect, and prompt urgent chemotherapy." | 8.31 | B-cell hepatosplenic lymphoma presenting in adult patient after spontaneous splenic rupture followed by severe persistent hypoglycaemia: type B lactic acidosis and acute liver failure. ( Gude, MF; Hamilton-Dutoit, S; Moen, M; Steiniche, T, 2023) |
| " Several patients with lactic acidosis and glucose levels below 1." | 7.80 | A patient with acute liver failure and extreme hypoglycaemia with lactic acidosis who was not in a coma: causes and consequences of lactate-protected hypoglycaemia. ( Gladden, LB; Goodwin, ML; McDonald, JR; Nijsten, MW; Oldenbeuving, G; Reijngoud, DJ; Sayilir, R, 2014) |
| "Data were collected early after admission and again at the time of onset of grade 3-4 hepatic encephalopathy from acetaminophen-induced fulminant hepatic failure." | 7.73 | Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. ( Larsen, FS; Schmidt, LE, 2006) |
| "Splenic rupture followed by lactic acidosis and hypoglycaemia should lead to suspicion of a cancer-mediated Warburg effect, and prompt urgent chemotherapy." | 4.31 | B-cell hepatosplenic lymphoma presenting in adult patient after spontaneous splenic rupture followed by severe persistent hypoglycaemia: type B lactic acidosis and acute liver failure. ( Gude, MF; Hamilton-Dutoit, S; Moen, M; Steiniche, T, 2023) |
| " Several patients with lactic acidosis and glucose levels below 1." | 3.80 | A patient with acute liver failure and extreme hypoglycaemia with lactic acidosis who was not in a coma: causes and consequences of lactate-protected hypoglycaemia. ( Gladden, LB; Goodwin, ML; McDonald, JR; Nijsten, MW; Oldenbeuving, G; Reijngoud, DJ; Sayilir, R, 2014) |
| "The pathogenesis of brain edema in an experimental model of ALF involves a cytotoxic mechanism: the metabolism of ammonia in astrocytes induces an increase of glutamine and lactate that appears to mediate cellular swelling." | 3.76 | Diffusion tensor imaging supports the cytotoxic origin of brain edema in a rat model of acute liver failure. ( Alonso, J; Chavarria, L; Cordoba, J; Lope-Piedrafita, S; Oria, M; Romero-Gimenez, J, 2010) |
| "Hyperammonemia causes brain edema and high intracranial pressure (ICP) in acute liver failure (ALF) by accumulation of glutamine in brain." | 3.74 | Cerebral glutamine concentration and lactate-pyruvate ratio in patients with acute liver failure. ( Bjerring, PN; Frederiksen, HJ; Hansen, BA; Hauerberg, J; Jorgensen, L; Larsen, FS; Tofteng, F, 2008) |
| "The most common causes of ALF were indeterminate liver failure (21%), acute hepatitis B (18%), acetaminophen ingestion (16%), and Budd-Chiari syndrome (9%)." | 3.74 | Prognostic implications of lactate, bilirubin, and etiology in German patients with acute liver failure. ( Bahr, MJ; Hadem, J; Klempnauer, J; Manns, MP; Rifai, K; Schneider, AS; Stiefel, P; Tillmann, HL; Wedemeyer, H, 2008) |
| "Data were collected early after admission and again at the time of onset of grade 3-4 hepatic encephalopathy from acetaminophen-induced fulminant hepatic failure." | 3.73 | Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. ( Larsen, FS; Schmidt, LE, 2006) |
| "Brain alterations such as hepatic encephalopathy or brain edema are usually associated with liver failure." | 2.50 | Magnetic resonance of the brain in chronic and acute liver failure. ( Chavarria, L; Cordoba, J, 2014) |
| "In patients with acute liver failure cerebral microdialysis studies show a linear correlation between the lactate to pyruvate ratio and the glutamine concentration, as well as to some of the adenosine triphosphate degradation products." | 2.49 | Changes in cerebral oxidative metabolism in patients with acute liver failure. ( Bjerring, PN; Larsen, FS, 2013) |
| "2." | 2.43 | Selection for acute liver failure: have we got it right? ( Blei, AT, 2005) |
| "There is increasing evidence that both acute liver failure and sepsis are accompanied by a hypermetabolic state in the hepatosplanchnic area, characterized by enhanced glycolysis and hyperlactatemia." | 2.42 | Splanchnic metabolism in acute liver failure and sepsis. ( Clemmesen, O; Larsen, FS; Ott, P, 2004) |
| "Massive cellular necrosis in acute liver failure (ALF) is dominantly immune mediated and innate immune cells are major pathophysiological determinants in liver damage." | 1.62 | Higher circulating natural killer cells and lower lactate levels at admission predict spontaneous survival in non-acetaminophen induced acute liver failure. ( Agrawal, T; Bajpai, M; Jagdish, RK; Maiwall, R; Rajan, V; Sarin, SK; Trehanpati, N, 2021) |
| " In a separate dose-response experiment cortex from healthy rats was incubated for 120 min in ammonium acetate in concentrations up to 80 mM prior to respirometry." | 1.46 | Accumulation of lactate in the rat brain during hyperammonaemia is not associated with impaired mitochondrial respiratory capacity. ( Bjerring, PN; Larsen, FS; Witt, AM, 2017) |
| "We investigated the association between hepatic encephalopathy (HE) scores, abnormal EEG or neuroimaging, and short-term outcome." | 1.40 | EEG abnormalities are associated with increased risk of transplant or poor outcome in children with acute liver failure. ( Alonso, E; Goldstein, J; Grimason, M; Hussain, E; Smith, CM; Wainwright, MS; Whitington, PF, 2014) |
| "Cerebral edema is a well-recognized and potentially fatal complication of acute liver failure (ALF)." | 1.39 | Cerebral microdialysis reflects the neuroprotective effect of fractionated plasma separation and adsorption in acute liver failure better and earlier than intracranial pressure: a controlled study in pigs. ( Koblihova, E; Laszikova, E; Pantoflicek, T; Prazak, J; Ryska, M; Ryska, O, 2013) |
| "Acetaminophen-induced acute liver failure (ALF) is a complex multiorgan illness." | 1.38 | Comparison of the sequential organ failure assessment score with the King's College Hospital criteria and the model for end-stage liver disease score for the prognosis of acetaminophen-induced acute liver failure. ( Agarwal, B; Betrosian, A; Burroughs, AK; Cholongitas, E; O'Beirne, J; Patch, D; Shaw, S; Theocharidou, E; Vasianopoulou, P, 2012) |
| "Seven patients with acute liver failure and high risk of intracranial hypertension were included for cerebral microdialysis and intracranial pressure monitoring." | 1.38 | The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure. ( Bjerring, PN; Clemmesen, JO; Frederiksen, HJ; Hauerberg, J; Larsen, FS; Nielsen, HB, 2012) |
| "Patients with acute liver failure (ALF) often die of intracranial pressure (IP) and cerebral herniation." | 1.37 | Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats. ( Agusti, A; Boix, J; Cauli, O; Cerdán, S; Felipo, V; López-Larrubia, P; Nieto-Charques, L; Rodrigo, R, 2011) |
| "The pathogenesis of cerebral edema in acute liver failure is suggested, in in vitro and animal studies, to involve a compromised oxidative metabolism with a decrease in cerebral ATP levels and an increase in purine concentrations." | 1.36 | Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure. ( Bjerring, PN; Frederiksen, HJ; Hansen, BA; Hauerberg, J; Jørgensen, L; Larsen, FS; Tofteng, F, 2010) |
| "Acute liver failure is often accompanied by hyperdynamic circulation, which is also a characteristic of septic shock." | 1.35 | Hemodynamics and metabolic studies on septic shock in patients with acute liver failure. ( Chen, PC; Chen, YC; Chu, YY; Fang, JT; Lien, JM; Peng, YS; Tang, JH; Tian, YC; Tsai, MH; Wu, CS; Yang, C, 2008) |
| "We previously demonstrated in pigs with acute liver failure (ALF) that albumin dialysis using the molecular adsorbents recirculating system (MARS) attenuated a rise in intracranial pressure (ICP)." | 1.34 | Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure. ( Belanger, M; Davies, NA; Jalan, R; Nedredal, GI; Revhaug, A; Rose, C; Sen, S; Ytrebø, LM, 2007) |
| "Fulminant hepatic encephalopathy has a high mortality." | 1.33 | Microdialysis in the management of hepatic encephalopathy. ( Al-Rawi, PG; Czosnyka, M; Gimson, A; Hutchinson, PJ; Menon, DK; O'Connell, MT, 2006) |
| "Hepatocyte regeneration in acute hepatic failure is essential for recovery, but requires a large amount of energy." | 1.29 | Plasma exchange and the arterial blood ketone body ratio in patients with acute hepatic failure. ( Maeda, T; Onishi, S; Saibara, T; Yamamoto, Y, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (1.69) | 18.2507 |
| 2000's | 23 (38.98) | 29.6817 |
| 2010's | 31 (52.54) | 24.3611 |
| 2020's | 4 (6.78) | 2.80 |
| Authors | Studies |
|---|---|
| Alhadab, A | 1 |
| AlShihabi, H | 1 |
| Mohamed, F | 1 |
| AlDuhilib, Z | 1 |
| Arain, Z | 1 |
| Bader, R | 1 |
| Moen, M | 1 |
| Hamilton-Dutoit, S | 1 |
| Steiniche, T | 1 |
| Gude, MF | 1 |
| Figueira, ERR | 1 |
| Rocha-Filho, JA | 1 |
| Lanchotte, C | 1 |
| Nacif, LS | 1 |
| de Paiva Haddad, LB | 1 |
| Assalin, AR | 1 |
| Shinkado, YR | 1 |
| Vintimilla, AM | 1 |
| Galvao, FHF | 1 |
| D'Albuquerque, LAC | 1 |
| Agrawal, T | 1 |
| Maiwall, R | 1 |
| Rajan, V | 1 |
| Bajpai, M | 1 |
| Jagdish, RK | 1 |
| Sarin, SK | 1 |
| Trehanpati, N | 1 |
| Wei, YL | 1 |
| Tian, Q | 1 |
| Zhao, XX | 1 |
| Qiu, GZ | 1 |
| Xu, Y | 1 |
| Sasaki, K | 1 |
| Sakamoto, S | 1 |
| Uchida, H | 1 |
| Narumoto, S | 1 |
| Shigeta, T | 1 |
| Fukuda, A | 1 |
| Ito, R | 1 |
| Irie, R | 1 |
| Yoshioka, T | 1 |
| Murayama, K | 1 |
| Kasahara, M | 1 |
| Michard, B | 1 |
| Artzner, T | 1 |
| Lebas, B | 1 |
| Besch, C | 1 |
| Guillot, M | 1 |
| Faitot, F | 1 |
| Lefebvre, F | 1 |
| Bachellier, P | 1 |
| Castelain, V | 1 |
| Maestraggi, Q | 1 |
| Schneider, F | 1 |
| Prazak, J | 2 |
| Laszikova, E | 2 |
| Pantoflicek, T | 2 |
| Ryska, O | 2 |
| Koblihova, E | 2 |
| Ryska, M | 2 |
| Chavarria, L | 3 |
| Cordoba, J | 3 |
| Hussain, E | 1 |
| Grimason, M | 1 |
| Goldstein, J | 1 |
| Smith, CM | 1 |
| Alonso, E | 1 |
| Whitington, PF | 1 |
| Wainwright, MS | 1 |
| Amathieu, R | 1 |
| Triba, MN | 1 |
| Nahon, P | 1 |
| Bouchemal, N | 1 |
| Kamoun, W | 1 |
| Haouache, H | 1 |
| Trinchet, JC | 1 |
| Savarin, P | 1 |
| Le Moyec, L | 1 |
| Dhonneur, G | 1 |
| Chang, RA | 1 |
| Chen, Z | 1 |
| Li, ZF | 1 |
| Oldenbeuving, G | 1 |
| McDonald, JR | 1 |
| Goodwin, ML | 1 |
| Sayilir, R | 1 |
| Reijngoud, DJ | 1 |
| Gladden, LB | 1 |
| Nijsten, MW | 1 |
| Romero-Giménez, J | 2 |
| Monteagudo, E | 1 |
| Lope-Piedrafita, S | 2 |
| Maharaj, R | 1 |
| Pingitore, A | 1 |
| Menon, K | 1 |
| Kane, P | 1 |
| Wendon, J | 1 |
| Bernal, W | 3 |
| Liu, M | 1 |
| Yang, J | 1 |
| Hu, W | 1 |
| Zhang, S | 1 |
| Wang, Y | 1 |
| Hertz, L | 1 |
| Song, D | 1 |
| Peng, L | 1 |
| Chen, Y | 1 |
| Özçay, F | 1 |
| Karadağ Öncel, E | 1 |
| Barış, Z | 1 |
| Canan, O | 1 |
| Moray, G | 1 |
| Haberal, M | 1 |
| Witt, AM | 1 |
| Larsen, FS | 10 |
| Bjerring, PN | 5 |
| Feldman, AG | 1 |
| Sokol, RJ | 1 |
| Hardison, RM | 1 |
| Alonso, EM | 1 |
| Squires, RH | 1 |
| Narkewicz, MR | 1 |
| Tsai, MH | 1 |
| Chen, YC | 1 |
| Lien, JM | 1 |
| Tian, YC | 1 |
| Peng, YS | 1 |
| Fang, JT | 1 |
| Yang, C | 1 |
| Tang, JH | 1 |
| Chu, YY | 1 |
| Chen, PC | 1 |
| Wu, CS | 1 |
| Novelli, G | 1 |
| Rossi, M | 1 |
| Ferretti, G | 1 |
| Pugliese, F | 1 |
| Ruberto, F | 1 |
| Lai, Q | 1 |
| Novelli, S | 1 |
| Piemonte, V | 1 |
| Turchetti, L | 1 |
| Morabito, V | 1 |
| Annesini, MC | 1 |
| Berloco, PB | 1 |
| Oria, M | 1 |
| Alonso, J | 1 |
| Du, WB | 1 |
| Pan, XP | 1 |
| Li, LJ | 1 |
| Schmidt, LE | 2 |
| Kjelland, CB | 1 |
| Djogovic, D | 1 |
| Hauerberg, J | 4 |
| Jørgensen, L | 1 |
| Frederiksen, HJ | 4 |
| Tofteng, F | 2 |
| Hansen, BA | 3 |
| Westbrook, RH | 1 |
| Yeoman, AD | 1 |
| Joshi, D | 1 |
| Heaton, ND | 2 |
| Quaglia, A | 1 |
| O'Grady, JG | 1 |
| Auzinger, G | 1 |
| Heneghan, MA | 1 |
| Wendon, JA | 2 |
| Cauli, O | 1 |
| López-Larrubia, P | 1 |
| Rodrigo, R | 1 |
| Agusti, A | 1 |
| Boix, J | 1 |
| Nieto-Charques, L | 1 |
| Cerdán, S | 1 |
| Felipo, V | 1 |
| Dabos, KJ | 1 |
| Whalen, HR | 1 |
| Newsome, PN | 1 |
| Parkinson, JA | 1 |
| Henderson, NC | 1 |
| Sadler, IH | 1 |
| Hayes, PC | 1 |
| Plevris, JN | 1 |
| Cholongitas, E | 2 |
| Theocharidou, E | 1 |
| Vasianopoulou, P | 1 |
| Betrosian, A | 1 |
| Shaw, S | 3 |
| Patch, D | 3 |
| O'Beirne, J | 2 |
| Agarwal, B | 1 |
| Burroughs, AK | 3 |
| Nielsen, HB | 1 |
| Clemmesen, JO | 1 |
| Li, GZ | 1 |
| Wang, ZH | 1 |
| Cui, W | 1 |
| Fu, JL | 1 |
| Wang, YR | 1 |
| Liu, P | 1 |
| Roy, P | 1 |
| Das, S | 1 |
| Auddy, RG | 1 |
| Saha, A | 1 |
| Mukherjee, A | 1 |
| Zwingmann, C | 2 |
| Chatauret, N | 4 |
| Leibfritz, D | 2 |
| Butterworth, RF | 4 |
| Rose, C | 4 |
| van de Kerkhove, MP | 1 |
| Di Florio, E | 1 |
| Scuderi, V | 1 |
| Mancini, A | 1 |
| Belli, A | 1 |
| Bracco, A | 1 |
| Scala, D | 1 |
| Scala, S | 1 |
| Zeuli, L | 1 |
| Di Nicuolo, G | 1 |
| Amoroso, P | 1 |
| Calise, F | 1 |
| Chamuleau, RA | 1 |
| Clemmesen, O | 1 |
| Ott, P | 1 |
| Lee, KU | 1 |
| Zheng, LX | 1 |
| Cho, YB | 1 |
| Kim, KH | 1 |
| Ha, J | 1 |
| Suh, KS | 1 |
| Jung, SE | 1 |
| Macquillan, GC | 2 |
| Seyam, MS | 1 |
| Nightingale, P | 1 |
| Neuberger, JM | 1 |
| Murphy, N | 1 |
| Blei, AT | 1 |
| Cholongitas, EB | 1 |
| Betrossian, A | 2 |
| Leandro, G | 1 |
| Hutchinson, PJ | 1 |
| Gimson, A | 1 |
| Al-Rawi, PG | 1 |
| O'Connell, MT | 1 |
| Czosnyka, M | 1 |
| Menon, DK | 1 |
| Eefsen, M | 1 |
| Dethloff, T | 1 |
| Ytrebø, LM | 1 |
| Davies, NA | 1 |
| Sen, S | 1 |
| Nedredal, GI | 1 |
| Belanger, M | 1 |
| Revhaug, A | 1 |
| Jalan, R | 1 |
| Gow, PJ | 1 |
| Warrilow, S | 1 |
| Lontos, S | 1 |
| Lubel, J | 1 |
| Wongseelashote, S | 1 |
| Jones, RM | 1 |
| Bellomo, R | 1 |
| Angus, PW | 1 |
| Senzolo, M | 1 |
| Jorgensen, L | 1 |
| Hadem, J | 1 |
| Stiefel, P | 1 |
| Bahr, MJ | 1 |
| Tillmann, HL | 1 |
| Rifai, K | 1 |
| Klempnauer, J | 1 |
| Wedemeyer, H | 1 |
| Manns, MP | 1 |
| Schneider, AS | 1 |
| Saibara, T | 1 |
| Maeda, T | 1 |
| Onishi, S | 1 |
| Yamamoto, Y | 1 |
| Pere, P | 1 |
| Höckerstedt, K | 1 |
| Isoniemi, H | 1 |
| Lindgren, L | 1 |
| Murphy, ND | 1 |
| Kodakat, SK | 1 |
| Jooste, CA | 1 |
| Muiesan, P | 1 |
| Rela, M | 1 |
| Therrien, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-Center Group to Study Acute Liver Failure in Children[NCT00986648] | 158 participants (Actual) | Observational | 2000-01-31 | Completed | |||
| Cerebral Microdialysis in Patients With Fulminant Hepatic Failure[NCT00836420] | 50 participants (Actual) | Observational | 2000-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for lactic acid and Acute Hepatic Failure
| Article | Year |
|---|---|
Magnetic resonance of the brain in chronic and acute liver failure.
Topics: Aspartic Acid; Biomarkers; Brain; Brain Chemistry; Brain Edema; Choline; Creatine; Glutamic Acid; Gl | 2014 |
Multifactorial Effects on Different Types of Brain Cells Contribute to Ammonia Toxicity.
Topics: Ammonia; Animals; Astrocytes; Brain; Cyclic GMP; Energy Metabolism; Glutamine; Hepatic Encephalopath | 2017 |
Prognostic models for acute liver failure.
Topics: alpha-Fetoproteins; Ammonia; Humans; Lactic Acid; Liver Failure, Acute; Models, Biological; Phosphat | 2010 |
The role of serum lactate in the acute care setting.
Topics: Acidosis, Lactic; Adult; Aged; Antiretroviral Therapy, Highly Active; Biomarkers; Critical Care; Dru | 2010 |
Changes in cerebral oxidative metabolism in patients with acute liver failure.
Topics: Amino Acids; Ammonia; Animals; Brain; Brain Chemistry; Humans; Hyperammonemia; Lactic Acid; Liver Fa | 2013 |
Splanchnic metabolism in acute liver failure and sepsis.
Topics: Humans; Ketone Bodies; Lactic Acid; Liver Failure, Acute; Oxygen Consumption; Sepsis; Splanchnic Cir | 2004 |
Selection for acute liver failure: have we got it right?
Topics: alpha-Fetoproteins; Biomarkers; Decision Making; Graft Survival; Humans; Lactic Acid; Liver Failure, | 2005 |
1 trial available for lactic acid and Acute Hepatic Failure
| Article | Year |
|---|---|
Bridging a patient with acute liver failure to liver transplantation by the AMC-bioartificial liver.
Topics: Adult; Ammonia; Animals; Bilirubin; Female; Hepatitis B; Hepatocytes; Humans; Lactic Acid; Liver Fai | 2003 |
51 other studies available for lactic acid and Acute Hepatic Failure
| Article | Year |
|---|---|
Pediatric acute liver failure in Saudi Arabia: prognostic indicators, outcomes and the role of genetic testing.
Topics: Child; Genetic Testing; Humans; Lactic Acid; Liver Failure, Acute; Prognosis; Retrospective Studies; | 2023 |
B-cell hepatosplenic lymphoma presenting in adult patient after spontaneous splenic rupture followed by severe persistent hypoglycaemia: type B lactic acidosis and acute liver failure.
Topics: Acidosis, Lactic; Adult; Humans; Hypoglycemia; Lactic Acid; Liver Failure, Acute; Lymphoma, Non-Hodg | 2023 |
Creatinine-lactate score predicts mortality in non-acetaminophen-induced acute liver failure in patients listed for liver transplantation.
Topics: Adult; Creatinine; Female; Humans; Lactic Acid; Liver Failure, Acute; Liver Transplantation; Male; M | 2021 |
Higher circulating natural killer cells and lower lactate levels at admission predict spontaneous survival in non-acetaminophen induced acute liver failure.
Topics: Adult; Female; Humans; Killer Cells, Natural; Lactic Acid; Liver Failure, Acute; Male; Middle Aged; | 2021 |
Association between MFN2 gene polymorphisms and the risk and prognosis of acute liver failure: a case-control study in a Chinese population.
Topics: Adult; Ammonia; Asian People; Case-Control Studies; China; Female; Gene Frequency; Genetic Predispos | 2017 |
Liver Transplantation for Mitochondrial Respiratory Chain Disorder: A Single-Center Experience and Excellent Marker of Differential Diagnosis.
Topics: Adult; Biomarkers; Diagnosis, Differential; Female; Humans; Lactic Acid; Liver Failure, Acute; Liver | 2017 |
Liver transplantation in critically ill patients: Preoperative predictive factors of post-transplant mortality to avoid futility.
Topics: Adult; Critical Illness; Female; Follow-Up Studies; Graft Rejection; Humans; Lactic Acid; Liver Fail | 2017 |
Cerebral microdialysis reflects the neuroprotective effect of fractionated plasma separation and adsorption in acute liver failure better and earlier than intracranial pressure: a controlled study in pigs.
Topics: Ammonia; Animals; Brain Edema; Cerebrum; Extracorporeal Circulation; Glucose; Glutamic Acid; Glutami | 2013 |
EEG abnormalities are associated with increased risk of transplant or poor outcome in children with acute liver failure.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Child; Child, Preschool; Electroencephalography; | 2014 |
Serum 1H-NMR metabolomic fingerprints of acute-on-chronic liver failure in intensive care unit patients with alcoholic cirrhosis.
Topics: Biomarkers; Creatinine; Glutamine; Humans; Intensive Care Units; Ketone Bodies; Lactic Acid; Liver C | 2014 |
Role of HGF-loaded nanoparticles in treating rat acute hepatic failure.
Topics: Animals; Biomarkers; Cells, Cultured; Chemistry, Pharmaceutical; Chitosan; Delayed-Action Preparatio | 2013 |
A patient with acute liver failure and extreme hypoglycaemia with lactic acidosis who was not in a coma: causes and consequences of lactate-protected hypoglycaemia.
Topics: Acetaminophen; Acidosis, Lactic; Analgesics, Non-Narcotic; Blood Glucose; Follow-Up Studies; Humans; | 2014 |
Real-time assessment of ¹³C metabolism reveals an early lactate increase in the brain of rats with acute liver failure.
Topics: Alanine; Animals; Brain; Carbon; Carbon Isotopes; Computer Systems; Disease Progression; Lactic Acid | 2015 |
Images of the Month: MDMA-Induced Acute Liver Failure and Transient Abdominal Pneumatosis.
Topics: Adult; Female; Heart; Humans; Ileus; Kidney; Lactic Acid; Liver; Liver Failure, Acute; N-Methyl-3,4- | 2015 |
Superior performance of co-cultured mesenchymal stem cells and hepatocytes in poly(lactic acid-glycolic acid) scaffolds for the treatment of acute liver failure.
Topics: Animals; Biocompatible Materials; Cell Differentiation; Cell Survival; Cells, Cultured; Coculture Te | 2016 |
Etiologies, outcomes, and prognostic factors of pediatric acute liver failure: A single center's experience in Turkey.
Topics: Adolescent; Ammonia; Bilirubin; Blood Coagulation Tests; Child; Child, Preschool; Female; Hepatitis | 2016 |
Accumulation of lactate in the rat brain during hyperammonaemia is not associated with impaired mitochondrial respiratory capacity.
Topics: Animals; Biosensing Techniques; Brain Chemistry; Cerebral Cortex; Citric Acid Cycle; Encephalitis; H | 2017 |
Lactate and Lactate: Pyruvate Ratio in the Diagnosis and Outcomes of Pediatric Acute Liver Failure.
Topics: Adolescent; Age Factors; Biomarkers; Child; Child, Preschool; Cohort Studies; Female; Humans; Lactic | 2017 |
Hemodynamics and metabolic studies on septic shock in patients with acute liver failure.
Topics: Aldosterone; APACHE; Blood Gas Analysis; Female; Hemodynamics; Hepatitis B; Hospital Mortality; Huma | 2008 |
Predictive criteria for the outcome of patients with acute liver failure treated with the albumin dialysis molecular adsorbent recirculating system.
Topics: Adult; Albumins; Critical Care; Cytokines; Dialysis; Female; Hemodynamics; Humans; Lactic Acid; Live | 2009 |
Diffusion tensor imaging supports the cytotoxic origin of brain edema in a rat model of acute liver failure.
Topics: Ammonia; Animals; Astrocytes; Blood-Brain Barrier; Brain; Brain Edema; Diffusion Tensor Imaging; Glu | 2010 |
Is lactate concentration of major value in determining the prognosis in patients with acute liver failure? Hardly.
Topics: Acetaminophen; Humans; Lactic Acid; Liver Failure, Acute; Liver Transplantation; Patient Selection; | 2010 |
Lactate is important in determining prognosis in acute liver failure.
Topics: Humans; Lactic Acid; Liver Failure, Acute; Liver Transplantation; Patient Selection; Prognosis | 2010 |
Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure.
Topics: Adolescent; Adult; Brain; Brain Edema; Female; Humans; Hyperammonemia; Hypoxanthine; Inosine; Intrac | 2010 |
Outcomes of severe pregnancy-related liver disease: refining the role of transplantation.
Topics: Adult; Fatty Liver; Female; Humans; Hypertension, Pregnancy-Induced; Lactic Acid; Liver Diseases; Li | 2010 |
Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats.
Topics: Ammonia; Animals; Blood-Brain Barrier; Brain Edema; Capillary Permeability; Cerebellum; Cerebrum; En | 2011 |
Impaired gluconeogenesis in a porcine model of paracetamol induced acute liver failure.
Topics: Acetaminophen; Amino Acids; Animals; Biomarkers; Citric Acid Cycle; Disease Models, Animal; Gluconeo | 2011 |
Comparison of the sequential organ failure assessment score with the King's College Hospital criteria and the model for end-stage liver disease score for the prognosis of acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; APACHE; Biomarkers; Chemical and Drug Induced Liver | 2012 |
Artificial liver support system reduces intracranial pressure more effectively than bioartificial system: an experimental study.
Topics: Ammonia; Animals; Bilirubin; Biomarkers; Cerebrovascular Circulation; Disease Models, Animal; Equipm | 2012 |
The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure.
Topics: Adult; Amino Acids; Cerebrum; Dialysis Solutions; Extracorporeal Circulation; Female; Glutamine; Hep | 2012 |
Tumor necrosis factor alpha increases intestinal permeability in mice with fulminant hepatic failure.
Topics: Animals; Claudin-1; Colon; Intestinal Mucosa; Lactic Acid; Liver Failure, Acute; Male; Mice; Mice, I | 2012 |
Engineered andrographolide nanoparticles mitigate paracetamol hepatotoxicity in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Diterpenes; Heparin; Lac | 2013 |
Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study.
Topics: Amino Acids; Ammonia; Animals; Blood; Body Water; Brain; Brain Edema; Carbon Isotopes; Glucose; Hepa | 2003 |
Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects.
Topics: Ammonia; Brain; Brain Edema; Glutamic Acid; Humans; Hypothermia, Induced; Lactic Acid; Liver Failure | 2002 |
Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study.
Topics: Alanine; Amino Acids; Animals; Brain; Citric Acid Cycle; Glucose; Hypothermia, Induced; Lactic Acid; | 2003 |
An experimental animal model of fulminant hepatic failure in pigs.
Topics: Acidosis; Ammonia; Animals; Aspartate Aminotransferases; Bilirubin; Blood Glucose; Blood Urea Nitrog | 2005 |
Blood lactate but not serum phosphate levels can predict patient outcome in fulminant hepatic failure.
Topics: Adult; Biomarkers; Female; Humans; Lactic Acid; Liver Failure, Acute; Liver Transplantation; Male; M | 2005 |
Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Child; Female; Hepatic Encephalopa | 2006 |
King's criteria, APACHE II, and SOFA scores in acute liver failure.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; APACHE; Female; Humans; Lactic Acid; Liver Failure, | 2006 |
Is it worthwhile to use cerebral microdialysis in patients with acute liver failure?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Bra | 2006 |
Microdialysis in the management of hepatic encephalopathy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Blood Glucose; Brain; Brain Edema; Critical Care; Dextropro | 2006 |
Comparison of terlipressin and noradrenalin on cerebral perfusion, intracranial pressure and cerebral extracellular concentrations of lactate and pyruvate in patients with acute liver failure in need of inotropic support.
Topics: Adolescent; Adult; Brain; Cerebrovascular Circulation; Extracellular Fluid; Female; Humans; Intracra | 2007 |
Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure.
Topics: Ammonia; Animals; Brain Chemistry; Disease Models, Animal; Extracellular Space; Female; Glutamic Aci | 2007 |
Time to review the selection criteria for transplantation in paracetamol-induced fulminant hepatic failure?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Biomarkers; Humans; Lactic Acid; Liver Failure, Acute; Live | 2007 |
Prognostic impact of lactate in acute liver failure.
Topics: Adult; Biomarkers; Female; Follow-Up Studies; Humans; Lactic Acid; Liver Failure, Acute; Male; Progn | 2008 |
Cerebral glutamine concentration and lactate-pyruvate ratio in patients with acute liver failure.
Topics: Adolescent; Adult; Aged; Astrocytes; Brain; Brain Edema; Critical Care; Female; Glutamine; Humans; H | 2008 |
Prognostic implications of lactate, bilirubin, and etiology in German patients with acute liver failure.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Bilirubin; Biomarkers; Budd-Chiari | 2008 |
Plasma exchange and the arterial blood ketone body ratio in patients with acute hepatic failure.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Aged; Arteries; Child; Citrates; Citric Acid; Female; H | 1994 |
Cerebral blood flow and oxygenation in liver transplantation for acute or chronic hepatic disease without venovenous bypass.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Blood Flow Velocity; Brain; Cerebrovascular Circulatio | 2000 |
Liver and intestinal lactate metabolism in patients with acute hepatic failure undergoing liver transplantation.
Topics: Female; Hepatic Veins; Humans; International Normalized Ratio; Intestinal Mucosa; Lactic Acid; Liver | 2001 |
Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure.
Topics: Ammonia; Animals; Brain; Brain Edema; Energy Metabolism; Hepatic Encephalopathy; Hypothermia, Induce | 2001 |