lactic acid has been researched along with Acute Brain Injuries in 269 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study has examined the anticonvulsant and neuroprotective effect of group II metabotropic glutamate receptor (mGluR) agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC) in the model of seizures induced in immature 12-day-old rats by bilateral intracerebroventricular infusion of dl-homocysteic acid (DL-HCA, 600 nmol/side)." | 7.73 | Seizures induced in immature rats by homocysteic acid and the associated brain damage are prevented by group II metabotropic glutamate receptor agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate. ( Druga, R; Folbergrová, J; Haugvicová, R; Kubová, H; Mares, P; Otáhal, J, 2005) |
| "Objective To investigate the effect of focal hypothermia (LH) on traumatic brain edema and the content of lactic acid in rat brain tissue." | 7.72 | [Effect of focal hypothermia on traumatic brain edema and the content of lactic acid in the brain tissue in rats]. ( Li, CH; Liang, YM; Liu, YS; Qu, HT; Wang, GW, 2004) |
| "Lisuride is a dopaminergic agonist with additional serotoninergic, adrenergic, and glutamate antagonistic properties." | 5.37 | Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats. ( Kiening, KL; Sakowitz, OW; Simunovic, F; Unterberg, AW; Zweckberger, K, 2011) |
| "Hyperglycemia was found consistently within 12 hours after injury (224 +/- 98 mg/dl, P less than 0." | 5.27 | Hyperglycemia, cerebrospinal fluid lactic acidosis, and cerebral blood flow in severely head-injured patients. ( De Salles, AA; Muizelaar, JP; Young, HF, 1987) |
| " Despite the use of barbiturate coma in patients with refractory intracranial hypertension, persistent release or impaired uptake of glutamate may be associated with continuous anaerobic metabolism, as shown by increases in cerebrospinal fluid hypoxanthine and lactate levels." | 5.09 | Thiopental attenuates energetic impairment but fails to normalize cerebrospinal fluid glutamate in brain-injured patients. ( Kossmann, T; Morganti-Kossmann, MC; Pleines, UE; Stocker, R; Stover, JF, 1999) |
| " This review discusses 3 issues that concern homeostasis in the acute care of trauma patients directly related to the stress response: hyperglycemia, lactic acidosis, and hypothermia." | 4.89 | Trauma and aggressive homeostasis management. ( Baranov, D; Neligan, PJ, 2013) |
| "Three important issues concerning homeostasis in the acute care of trauma patients that are related directly to the stress response are hyperglycemia, lactic acidosis, and hypothermia." | 4.84 | Trauma and aggressive homeostasis management. ( Baranov, D; Neligan, P, 2007) |
| "An LP ratio >25 and glycerol >100 micromol/L, but not glutamate >12 micromol/L, were associated with significantly higher risk of imminent intracranial hypertension (odds ratio: 9." | 3.74 | Metabolic failure precedes intracranial pressure rises in traumatic brain injury: a microdialysis study. ( Belli, A; Kitchen, N; Petzold, A; Russo, S; Sen, J; Smith, M, 2008) |
| "The present study has examined the anticonvulsant and neuroprotective effect of group II metabotropic glutamate receptor (mGluR) agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC) in the model of seizures induced in immature 12-day-old rats by bilateral intracerebroventricular infusion of dl-homocysteic acid (DL-HCA, 600 nmol/side)." | 3.73 | Seizures induced in immature rats by homocysteic acid and the associated brain damage are prevented by group II metabotropic glutamate receptor agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate. ( Druga, R; Folbergrová, J; Haugvicová, R; Kubová, H; Mares, P; Otáhal, J, 2005) |
| "Objective To investigate the effect of focal hypothermia (LH) on traumatic brain edema and the content of lactic acid in rat brain tissue." | 3.72 | [Effect of focal hypothermia on traumatic brain edema and the content of lactic acid in the brain tissue in rats]. ( Li, CH; Liang, YM; Liu, YS; Qu, HT; Wang, GW, 2004) |
| " Infarcts in substantia nigra pars reticulata were evoked by prolonged pilocarpine-induced status epilepticus." | 3.68 | Immunohistochemical studies with antibodies to neurofilament proteins on axonal damage in experimental focal lesions in rat. ( Bellander, BM; Ingvar, M; Meller, D; Schmidt-Kastner, R, 1993) |
| " It was revealed that alterations in carbohydrate metabolism in the form of lactic acidosis and anaerobiosis developed not only because of hemodynamic and ventilatory disorders." | 3.68 | [Study of the changes in carbohydrate metabolism as a diagnostic test of acute hypothalamic syndrome in severe cranio-cerebral trauma]. ( Borshchagovskiĭ, ML; Krauze, VE; Kuznetsova, VM; Raĭkhinshteĭn, VE, 1990) |
| "Mean Glasgow Coma Scale (GCS) score was 7 (range 4-10)." | 2.72 | Intracerebral microdialysis and intracranial compliance monitoring of patients with traumatic brain injury. ( Contant, CF; Enblad, P; Howells, T; Nilsson, P; Piper, I; Ronne-Engström, E; Salci, K, 2006) |
| " It was the purpose of this study to develop pharmacokinetic and pharmacodynamic models for determination of a dose for a pivotal Phase III clinical trial of DCA in patients with traumatic brain injury (TBI)." | 2.70 | Dichloroacetate: population pharmacokinetics with a pharmacodynamic sequential link model. ( Capparelli, EV; Dziewanowska, Z; Fox, AW; Lane, JR; Turkel, CC; Williams, PJ, 2001) |
| "For better care of postcardiac arrest patients, objective serial assessments of brain injury severity are needed." | 1.48 | Monitoring of Cerebral Metabolism in Postcardiac Arrest Patients: A Pilot Study. ( Chae, MK; Kang, SY; Lee, SE; Sim, MS, 2018) |
| "In TBI patients, seizures and periodic discharges are one mechanism for metabolic crisis, and hence represent a therapeutic target for future study." | 1.43 | Metabolic crisis occurs with seizures and periodic discharges after brain trauma. ( Buitrago-Blanco, M; Claassen, J; McArthur, D; Nuwer, M; Prins, M; Tu, B; Tubi, M; Velazquez, AG; Vespa, P, 2016) |
| "Taurine is an abundant amino acid in the nervous system, which has been proved to possess antioxidation, osmoregulation and membrane stabilization." | 1.43 | Neuroprotective actions of taurine on hypoxic-ischemic brain damage in neonatal rats. ( Hao, YJ; Li, YX; Ma, PS; Niu, Y; Sun, T; Wu, W; Yu, JQ; Zhou, R; Zhu, XY, 2016) |
| " The effect of LLL was further bolstered by combination with metabolic substrates such as pyruvate or lactate both in vivo and in vitro." | 1.42 | Low-level light in combination with metabolic modulators for effective therapy of injured brain. ( Dong, T; Hamblin, MR; Wu, MX; Zhang, Q, 2015) |
| "Acetylpuerarin (AP) is an acetylated derivative of puerarin (PUE)." | 1.42 | Polysorbate 80-coated PLGA nanoparticles improve the permeability of acetylpuerarin and enhance its brain-protective effects in rats. ( Lou, H; Shi, H; Sun, D; Xue, A; Zhang, B; Zhang, X, 2015) |
| "Lisuride is a dopaminergic agonist with additional serotoninergic, adrenergic, and glutamate antagonistic properties." | 1.37 | Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats. ( Kiening, KL; Sakowitz, OW; Simunovic, F; Unterberg, AW; Zweckberger, K, 2011) |
| "Anesthetized rats were assigned to sham; brain injury (BI); controlled hemorrhagic shock (CHS); BI combined with CHS (combined injury [CI]); and CI groups resuscitated with 2." | 1.36 | Moderate Ringer's lactate solution resuscitation yields best neurological outcome in controlled hemorrhagic shock combined with brain injury in rats. ( Brotfain, EM; Dar, DE; Krausz, MM; Leibowitz, A; Semenikhina, L; Shapira, Y; Solopov, A; Soustiel, JF; Zaaroor, M, 2010) |
| "Hypotension was induced 2 h after trauma." | 1.36 | Metabolic effects of a late hypotensive insult combined with reduced intracranial compliance following traumatic brain injury in the rat. ( Contant, CF; Enblad, P; Goiny, M; Nilsson, P; Piper, I; Salci, K, 2010) |
| "In addition, the TBI-induced cerebral infarction, motor and proprioception deficits, and body weight loss evaluated 3 days after TBI were significantly attenuated by brain cooling." | 1.34 | Effect of brain cooling on brain ischemia and damage markers after fluid percussion brain injury in rats. ( Chang, CP; Chio, CC; Hsiao, SH; Kuo, JR; Lin, MT, 2007) |
| "No lactic acidosis was induced by the intravenous infusion of 280 mM L-lactate." | 1.34 | Effect of lactate therapy upon cognitive deficits after traumatic brain injury in the rat. ( Bullock, MR; Hamm, RJ; Harvey, HB; Holloway, R; Levasseur, JE; Rice, AC; Sun, D; Zhou, Z, 2007) |
| "Early brain death (within 48 h) was assumed to be due to early global ischemia." | 1.34 | Cerebral arterio-venous pCO2 difference, estimated respiratory quotient, and early posttraumatic outcome: comparison with arterio-venous lactate and oxygen differences. ( Chieregato, A; Fainardi, E; Marchi, M; Targa, L, 2007) |
| "These four children all had seizure activity and abnormal initial neurological examinations and required admission to the PICU." | 1.33 | Elevated lactate as an early marker of brain injury in inflicted traumatic brain injury. ( Ball, WS; Care, M; Cecil, KM; Makoroff, KL, 2005) |
| "Cerebral ischemia is recognized as one of the most important mechanisms responsible for secondary brain damage following severe traumatic brain injury (TBI), contributing to an increased mortality and a worse neurologic outcome." | 1.33 | Quantitation of ischemic events after severe traumatic brain injury in humans: a simple scoring system. ( Bullock, RM; Choi, S; Gilman, C; Kunene, NK; Mazzeo, AT, 2006) |
| "Brain alkalosis was associated with increased brain lactate/creatine (p < 0." | 1.31 | Brain alkaline intracellular pH after neonatal encephalopathy. ( Cowan, FM; Cox, IJ; Edwards, AD; Robertson, NJ, 2002) |
| "Global cerebral ischemia and increased anaerobic metabolism were considered according to AVDO2 and AVDL respectively." | 1.30 | Cerebral hemodynamic changes during sustained hypocapnia in severe head injury: can hyperventilation cause cerebral ischemia? ( Ausina, A; Báguena, M; Ferrer, A; Garnacho, A; Manrique, S; Nadal, M; Sahuquillo, J, 1998) |
| "However, false cerebral ischemia may be frequently found, if assessed by the lactate-oxygen index, because the denominator of the index (the arteriojugular oxygen content difference) frequently decreases as a function of decreasing hemoglobin, thus yielding false calculated ischemic high values for lactate-oxygen index despite normal cerebral oxygenation and lactate production." | 1.29 | Cerebral lactate-oxygen index in acute brain injury with acute anemia: assessment of false versus true ischemia. ( Cruz, J; Hoffstad, OJ; Jaggi, JL, 1994) |
| "Hyperglycemia was found consistently within 12 hours after injury (224 +/- 98 mg/dl, P less than 0." | 1.27 | Hyperglycemia, cerebrospinal fluid lactic acidosis, and cerebral blood flow in severely head-injured patients. ( De Salles, AA; Muizelaar, JP; Young, HF, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (4.83) | 18.7374 |
| 1990's | 40 (14.87) | 18.2507 |
| 2000's | 120 (44.61) | 29.6817 |
| 2010's | 85 (31.60) | 24.3611 |
| 2020's | 11 (4.09) | 2.80 |
| Authors | Studies |
|---|---|
| Rajagopalan, S | 1 |
| Baker, W | 1 |
| Mahanna-Gabrielli, E | 1 |
| Kofke, AW | 1 |
| Balu, R | 1 |
| Chaudhari, P | 1 |
| Madaan, A | 1 |
| Rivera, JC | 1 |
| Charfi, I | 1 |
| Habelrih, T | 1 |
| Hou, X | 1 |
| Nezhady, M | 1 |
| Lodygensky, G | 1 |
| Pineyro, G | 1 |
| Muanza, T | 1 |
| Chemtob, S | 1 |
| Giannì, G | 1 |
| Minini, A | 1 |
| Fratino, S | 1 |
| Peluso, L | 1 |
| Annoni, F | 1 |
| Oddo, M | 7 |
| Schuind, S | 1 |
| Creteur, J | 1 |
| Taccone, FS | 2 |
| Bogossian, EG | 1 |
| Lei, X | 1 |
| Qin, D | 1 |
| Zhu, G | 1 |
| Wang, S | 2 |
| Liu, Y | 3 |
| Liu, H | 2 |
| Wang, P | 2 |
| Wang, W | 2 |
| Cascant-Vilaplana, MM | 1 |
| Lara-Cantón, I | 1 |
| Núñez-Ramiro, A | 1 |
| Solaz-García, Á | 1 |
| Llorens-Salvador, R | 1 |
| Quintás, G | 1 |
| Kuligowski, J | 1 |
| Vento, M | 1 |
| Gouvêa Bogossian, E | 1 |
| Taleb, C | 1 |
| Aspide, R | 1 |
| Badenes, R | 1 |
| Battaglini, D | 1 |
| Bilotta, F | 1 |
| Blandino Ortiz, A | 1 |
| Caricato, A | 1 |
| Castioni, CA | 1 |
| Citerio, G | 1 |
| Ferraro, G | 1 |
| Martino, C | 1 |
| Melchionda, I | 1 |
| Montanaro, F | 1 |
| Monleon Lopez, B | 1 |
| Nato, CG | 1 |
| Piagnerelli, M | 1 |
| Picetti, E | 2 |
| Robba, C | 1 |
| Simonet, O | 1 |
| Thooft, A | 1 |
| Arulnathan, E | 1 |
| Manchanda, A | 1 |
| Dixit, R | 1 |
| Kumar, A | 1 |
| Casey, S | 1 |
| Goasdoue, K | 1 |
| Miller, SM | 1 |
| Brennan, GP | 1 |
| Cowin, G | 1 |
| O'Mahony, AG | 1 |
| Burke, C | 1 |
| Hallberg, B | 1 |
| Boylan, GB | 1 |
| Sullivan, AM | 1 |
| Henshall, DC | 1 |
| O'Keeffe, GW | 1 |
| Mooney, C | 1 |
| Bjorkman, T | 1 |
| Murray, DM | 1 |
| Tassinari, ID | 1 |
| Andrade, MKG | 1 |
| da Rosa, LA | 1 |
| Hoff, MLM | 1 |
| Nunes, RR | 1 |
| Vogt, EL | 1 |
| Fabres, RB | 1 |
| Sanches, EF | 1 |
| Netto, CA | 1 |
| Paz, AH | 1 |
| de Fraga, LS | 1 |
| Mölström, S | 1 |
| Nielsen, TH | 3 |
| Nordström, CH | 12 |
| Forsse, A | 2 |
| Möller, S | 1 |
| Venö, S | 1 |
| Mamaev, D | 1 |
| Tencer, T | 1 |
| Schmidt, H | 1 |
| Toft, P | 1 |
| Kong, VY | 1 |
| Weale, RD | 1 |
| Laing, GL | 1 |
| Bruce, JL | 1 |
| Oosthuizen, GV | 1 |
| Sartorius, B | 1 |
| Brysiewicz, P | 1 |
| Clarke, DL | 1 |
| Clausen, AH | 1 |
| Poulsen, FR | 1 |
| Chae, MK | 1 |
| Lee, SE | 1 |
| Kang, SY | 1 |
| Sim, MS | 1 |
| Singh, V | 1 |
| Zhou, T | 1 |
| Kalanuria, A | 1 |
| Andelius, TCK | 1 |
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| Kyng, KJ | 1 |
| Henriksen, TB | 1 |
| Sanchez, JJ | 1 |
| Bidot, CJ | 1 |
| O'Phelan, K | 5 |
| Gajavelli, S | 2 |
| Yokobori, S | 4 |
| Olvey, S | 1 |
| Jagid, J | 1 |
| Garcia, JA | 1 |
| Nemeth, Z | 1 |
| Bullock, R | 14 |
| Asgari, S | 1 |
| Vespa, P | 6 |
| Hu, X | 1 |
| Bai, W | 1 |
| Wang, X | 3 |
| Yuan, W | 1 |
| Wang, H | 1 |
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| Ernst, T | 1 |
| Park, D | 1 |
| Stenger, A | 1 |
| Denny, K | 1 |
| Green, D | 1 |
| Chang, C | 1 |
| Chang, L | 1 |
| Sala, N | 1 |
| Suys, T | 3 |
| Zerlauth, JB | 1 |
| Bouzat, P | 3 |
| Messerer, M | 1 |
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| Levivier, M | 1 |
| Magistretti, PJ | 3 |
| Meuli, R | 1 |
| Jalloh, I | 3 |
| Helmy, A | 3 |
| Shannon, RJ | 2 |
| Gallagher, CN | 5 |
| Menon, DK | 9 |
| Carpenter, KL | 7 |
| Hutchinson, PJ | 14 |
| Mazzeo, AT | 2 |
| Bullock, MR | 7 |
| Nielsen, T | 1 |
| Nielsen, H | 1 |
| Sajja, VS | 1 |
| Perrine, SA | 1 |
| Ghoddoussi, F | 1 |
| Hall, CS | 1 |
| Galloway, MP | 1 |
| VandeVord, PJ | 1 |
| Liang, MY | 1 |
| Tang, ZX | 1 |
| Chen, GX | 1 |
| Rong, J | 1 |
| Yao, JP | 1 |
| Chen, Z | 1 |
| Wu, ZK | 1 |
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| Auer, RN | 1 |
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| Sutherland, GR | 2 |
| de Lima Oliveira, M | 2 |
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| Lazaridis, C | 1 |
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| Haux, D | 2 |
| Unterberg, AW | 7 |
| Sakowitz, OW | 6 |
| Dienel, GA | 1 |
| Glenn, TC | 6 |
| Martin, NA | 6 |
| McArthur, DL | 6 |
| Hovda, DA | 12 |
| Johnson, ML | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Exogenous Sodium Lactate Infusion in Traumatic Brain Injury (ELI-TBI)[NCT02776488] | Phase 2 | 0 participants (Actual) | Interventional | 2020-09-30 | Withdrawn (stopped due to The manufacturer of sodium lactate has stopped making the medication) | ||
| Uncovering the 'ORIGINS' of Diabetes[NCT02226640] | 80 participants (Actual) | Observational | 2010-11-30 | Completed | |||
| Continuous, Non-invasive Monitoring of Intraoperative Cerebral Perfusion and Oxidative Metabolism (CPOM): a Knowledge Translation Study.[NCT03907904] | 40 participants (Anticipated) | Observational | 2019-07-01 | Recruiting | |||
| Spreading Depolarization and Ketamine Suppression[NCT02501941] | Phase 1 | 10 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Assessment of the Clinical Importance of Insulin Resistance & Steroid-Associated Hyperglycemia in Relapsing Multiple Sclerosis[NCT03004079] | 160 participants (Anticipated) | Observational | 2016-10-31 | Recruiting | |||
| Multimodality Monitoring Directed Management of Patients Suffering From Traumatic Brain Injury[NCT02993549] | 100 participants (Anticipated) | Observational | 2017-09-16 | Recruiting | |||
| Continuous Monitoring of Cerebral Metabolic State. Combined Intracerebral and Jugular Bulb Microdialysis in Neurocritical Care.[NCT03314779] | 12 participants (Actual) | Observational | 2017-08-28 | Completed | |||
| Conservative vs Conventional Oxygen Administration in Critically Ill Patients: Effects on ICU Mortality. A Multicentre Randomized Open Label Clinical Trial[NCT04198077] | Phase 4 | 1,000 participants (Anticipated) | Interventional | 2019-12-04 | Recruiting | ||
| Impact of Intermediate Normal Compared to High Normal Oxygen Levels on Outcomes of Patients Presenting in the Emergency Department With Severe Traumatic Brain Injury (INACHOS): a Pilot Randomized Controlled Trial[NCT05464277] | 50 participants (Anticipated) | Interventional | 2022-08-31 | Not yet recruiting | |||
| Cerebral Blood Flow (CBF) Disturbances Following Traumatic Brain Injury (TBI) and Subarachnoid Hemorrhage (SAH)[NCT00807833] | 20 participants (Actual) | Observational | 2009-02-28 | Completed | |||
| Safety and Efficacy of Therapeutic Hypothermia in Acute Ischemic Stroke Patients Treated With Mechanical Thrombectomy: a Prospective, Randomized, Controlled Clinical Study[NCT05779176] | 252 participants (Anticipated) | Interventional | 2023-05-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
18 reviews available for lactic acid and Acute Brain Injuries
| Article | Year |
|---|---|
The Impact of Short-Term Hyperoxia on Cerebral Metabolism: A Systematic Review and Meta-Analysis.
Topics: Brain Injuries; Glucose; Humans; Hyperoxia; Lactic Acid; Microdialysis; Observational Studies as Top | 2022 |
Temporal Evolution of Signal Alterations in the Deep Gray Nuclei in term Neonates With Hypoxic-Ischemic Brain Injury: A Comprehensive Review.
Topics: Brain; Brain Injuries; Diffusion Magnetic Resonance Imaging; Humans; Hypoxia-Ischemia, Brain; Infant | 2023 |
[Cerebral monitoring of neurocritical patients].
Topics: Brain; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Humans; Intracranial Pressure; L | 2018 |
Cerebral Microdialysis in Neurocritical Care.
Topics: Biomarkers; Brain Injuries; Brain Injuries, Traumatic; Glucose; Humans; Lactic Acid; Microdialysis; | 2018 |
Mitochondrial neuroprotection in traumatic brain injury: rationale and therapeutic strategies.
Topics: Animals; Brain Injuries; Cyclosporine; Humans; Lactic Acid; Mitochondria; Neuroprotective Agents; Ra | 2014 |
Lactate and the injured brain: friend or foe?
Topics: Brain Injuries; Cerebral Cortex; Cerebrovascular Circulation; Energy Metabolism; Female; Glycolysis; | 2014 |
Brain tissue oxygenation, lactate-pyruvate ratio, and cerebrovascular pressure reactivity monitoring in severe traumatic brain injury: systematic review and viewpoint.
Topics: Arterial Pressure; Brain Injuries; Cerebrovascular Circulation; Humans; Lactic Acid; Monitoring, Phy | 2014 |
Lactate shuttling and lactate use as fuel after traumatic brain injury: metabolic considerations.
Topics: Animals; Brain Injuries; Brain Ischemia; Glutamic Acid; Humans; Lactic Acid; Mitochondria; Oxidation | 2014 |
Cerebral Lactate Metabolism After Traumatic Brain Injury.
Topics: Animals; Brain Injuries; Cerebrovascular Circulation; Glucose; Humans; Hypoxia; Lactic Acid; Neuropr | 2016 |
A systematic review of Magnetic Resonance Imaging and Spectroscopy in brain injury after drowning.
Topics: Aspartic Acid; Brain Injuries; Child; Child, Preschool; Drowning; Female; Humans; Hypoxia, Brain; In | 2009 |
Trauma and aggressive homeostasis management.
Topics: Acidosis, Lactic; Brain Injuries; Homeostasis; Humans; Hyperglycemia; Hypothermia, Induced; Insulin; | 2013 |
Secondary mechanisms in traumatic brain injury: a nurse's perspective.
Topics: Brain Injuries; Excitatory Amino Acids; Free Radicals; Humans; Ion Channels; Lactic Acid; Lipid Pero | 1999 |
Hyperoxia in head injury: therapeutic tool?
Topics: Animals; Brain; Brain Injuries; Humans; Hyperbaric Oxygenation; Italy; Lactic Acid; Oxygen | 2004 |
Trauma and aggressive homeostasis management.
Topics: Acidosis; Animals; Brain Injuries; Homeostasis; Humans; Hyperglycemia; Hypothermia; Lactic Acid; Sho | 2007 |
[Astrocytes in health and disease].
Topics: Animals; Astrocytes; Blood-Brain Barrier; Brain Injuries; Calcium; Cerebrospinal Fluid; Cerebrovascu | 2007 |
[Lactate as an indicator of ischemic-traumatic brain injury].
Topics: Animals; Biomarkers; Brain Injuries; Brain Ischemia; Humans; Lactic Acid | 1999 |
Changes in the treatment of head injury.
Topics: Amino Acids; Animals; Brain Damage, Chronic; Brain Injuries; Critical Care; Free Radicals; Humans; I | 1991 |
Pathophysiology of cerebrospinal fluid in head injury: Part 1. Pathological changes in cerebrospinal fluid solute composition after traumatic injury.
Topics: Acetylcholine; Brain Edema; Brain Injuries; Calcium; Cerebrospinal Fluid Proteins; Dopamine; Fatty A | 1986 |
26 trials available for lactic acid and Acute Brain Injuries
| Article | Year |
|---|---|
Bedside microdialysis for detection of early brain injury after out-of-hospital cardiac arrest.
Topics: Adult; Aged; Biomarkers; Brain; Brain Injuries; Brain Ischemia; Cerebral Veins; Energy Metabolism; F | 2021 |
Increase in cerebral aerobic metabolism by normobaric hyperoxia after traumatic brain injury.
Topics: Adult; Brain Injuries; Female; Humans; Hyperoxia; Lactic Acid; Male; Microdialysis; Middle Aged; Oxi | 2008 |
Ventriculostomy for control of raised ICP in acute traumatic brain injury.
Topics: Adult; Blood Pressure; Brain Injuries; Cerebrospinal Fluid; Female; Glasgow Coma Scale; Humans; Intr | 2008 |
Mild hypothermia therapy reduces blood glucose and lactate and improves neurologic outcomes in patients with severe traumatic brain injury.
Topics: Adult; Blood Glucose; Brain Injuries; Female; Follow-Up Studies; Glasgow Outcome Scale; Humans; Hypo | 2011 |
Biochemical markers analyzed using microdialysis and traumatic brain injury outcomes.
Topics: Adult; Biomarkers; Brain Injuries; Critical Care; Female; Follow-Up Studies; Humans; Lactic Acid; Ma | 2011 |
Cerebral microdialysis: perioperative monitoring and treatment of severe neurosurgical patient.
Topics: Brain Injuries; Glucose; Glycerol; Humans; Intracranial Hemorrhage, Traumatic; Lactic Acid; Microdia | 2011 |
Cerebral microdialysis effects of propofol versus midazolam in severe traumatic brain injury.
Topics: Adult; Biomarkers; Brain Chemistry; Brain Injuries; Cerebral Cortex; Female; Glucose; Glutamic Acid; | 2012 |
A microdialysis study of oral vigabatrin administration in head injury patients: preliminary evaluation of multimodality monitoring.
Topics: Administration, Oral; Adolescent; Adult; Aged; Amino Acids; Anticonvulsants; Blood Pressure; Brain C | 2012 |
A pilot study of cerebral and haemodynamic physiological changes during sedation with dexmedetomidine or propofol in patients with acute brain injury.
Topics: Body Temperature; Brain Injuries; Consciousness Monitors; Cross-Over Studies; Dexmedetomidine; Glasg | 2012 |
Extracellular brain pH with or without hypoxia is a marker of profound metabolic derangement and increased mortality after traumatic brain injury.
Topics: Adult; Biomarkers; Brain; Brain Injuries; Disease-Free Survival; Female; Glucose; Humans; Hydrogen-I | 2013 |
Effect of hyperventilation on extracellular concentrations of glutamate, lactate, pyruvate, and local cerebral blood flow in patients with severe traumatic brain injury.
Topics: Adult; Brain; Brain Injuries; Brain Ischemia; Female; Glutamic Acid; Humans; Hyperventilation; Lacti | 2002 |
Assessment of the lower limit for cerebral perfusion pressure in severe head injuries by bedside monitoring of regional energy metabolism.
Topics: Adolescent; Adult; Aged; Blood Gas Analysis; Brain Chemistry; Brain Injuries; Cerebrovascular Circul | 2003 |
[Experiments in evaluation of brain oxygenation and metabolism based on continuous bilateral SjO2 monitoring and metabolic glucose transformations in patients after severe cranio-cerebral injuries].
Topics: Adult; Aged; Blood Glucose; Brain; Brain Injuries; Female; Glasgow Coma Scale; Humans; Jugular Veins | 2001 |
Relationships between cerebrospinal fluid markers of excitotoxicity, ischemia, and oxidative damage after severe TBI: the impact of gender, age, and hypothermia.
Topics: Adult; Age Factors; Biomarkers; Brain Injuries; Brain Ischemia; F2-Isoprostanes; Female; Glutamic Ac | 2004 |
Dynamic changes in brain glucose and lactate in pericontusional areas of the human cerebral cortex, monitored with rapid sampling on-line microdialysis: relationship with depolarisation-like events.
Topics: Adult; Aged; Brain; Brain Edema; Brain Injuries; Cerebral Cortex; Cortical Spreading Depression; Ele | 2005 |
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study.
Topics: Acute Disease; Adolescent; Adult; Brain Injuries; Brain Ischemia; Glucose; Humans; Incidence; Lactic | 2005 |
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study.
Topics: Acute Disease; Adolescent; Adult; Brain Injuries; Brain Ischemia; Glucose; Humans; Incidence; Lactic | 2005 |
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study.
Topics: Acute Disease; Adolescent; Adult; Brain Injuries; Brain Ischemia; Glucose; Humans; Incidence; Lactic | 2005 |
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study.
Topics: Acute Disease; Adolescent; Adult; Brain Injuries; Brain Ischemia; Glucose; Humans; Incidence; Lactic | 2005 |
Intracerebral microdialysis and intracranial compliance monitoring of patients with traumatic brain injury.
Topics: Adult; Brain Injuries; Coma; Compliance; Female; Fever; Glasgow Coma Scale; Humans; Lactic Acid; Mal | 2006 |
Comparison of moderate hyperventilation and mannitol for control of intracranial pressure control in patients with severe traumatic brain injury--a study of cerebral blood flow and metabolism.
Topics: Adolescent; Adult; Aged; Brain Edema; Brain Injuries; Brain Ischemia; Cerebral Cortex; Cerebrovascul | 2006 |
Lack of utility of arteriojugular venous differences of lactate as a reliable indicator of increased brain anaerobic metabolism in traumatic brain injury.
Topics: Adolescent; Adult; Aged; Brain; Brain Injuries; Female; Glasgow Outcome Scale; Humans; Jugular Veins | 2007 |
Near-infrared spectroscopy monitoring of brain oxygen in infant cardiac surgery.
Topics: Biomarkers; Brain; Brain Injuries; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Circulatory | 2007 |
Thiopental attenuates energetic impairment but fails to normalize cerebrospinal fluid glutamate in brain-injured patients.
Topics: Adolescent; Adult; Biomarkers; Brain Injuries; Electroencephalography; Female; Glutamic Acid; Humans | 1999 |
Low-dose prostacyclin in treatment of severe brain trauma evaluated with microdialysis and jugular bulb oxygen measurements.
Topics: Adult; Aged; Biomarkers; Brain Injuries; Energy Metabolism; Epoprostenol; Female; Humans; Hypoxia; J | 2000 |
High level of extracellular potassium and its correlates after severe head injury: relationship to high intracranial pressure.
Topics: Adolescent; Adult; Brain; Brain Chemistry; Brain Injuries; Cerebrovascular Circulation; Extracellula | 2000 |
Effects of hyperbaric oxygenation therapy on cerebral metabolism and intracranial pressure in severely brain injured patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Gas Analysis; Blood Pressure; Brain; Brain Injurie | 2001 |
Dichloroacetate: population pharmacokinetics with a pharmacodynamic sequential link model.
Topics: Adult; Aged; Bayes Theorem; Brain Injuries; Chromatography, High Pressure Liquid; Computer Simulatio | 2001 |
Clinical cerebral microdialysis: brain metabolism and brain tissue oxygenation after acute brain injury.
Topics: Adolescent; Adult; Brain; Brain Injuries; Critical Care; Female; Glucose; Glutamic Acid; Humans; Int | 2001 |
225 other studies available for lactic acid and Acute Brain Injuries
| Article | Year |
|---|---|
Hierarchical Cluster Analysis Identifies Distinct Physiological States After Acute Brain Injury.
Topics: Brain; Brain Injuries; Cluster Analysis; Hospital Mortality; Humans; Intracranial Pressure; Lactic A | 2022 |
Neuronal GPR81 regulates developmental brain angiogenesis and promotes brain recovery after a hypoxic ischemic insult.
Topics: Animals; Animals, Newborn; Brain; Brain Injuries; Female; Hypoxia-Ischemia, Brain; Infarction; Ische | 2022 |
To Investigate the Effect of Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI) in the Diagnosis of Mild Craniocerebral Injury.
Topics: Brain Injuries; Brain Injuries, Traumatic; Choline; Coma; Creatinine; Diffusion Tensor Imaging; Huma | 2022 |
Clinical application of BIS combined with LCR in assessing brain function and prognosis of patients with severe carbon monoxide poisoning.
Topics: Brain; Brain Injuries; Carbon Monoxide Poisoning; Humans; Lactic Acid; Prognosis; Retrospective Stud | 2023 |
Clinical application of BIS combined with LCR in assessing brain function and prognosis of patients with severe carbon monoxide poisoning.
Topics: Brain; Brain Injuries; Carbon Monoxide Poisoning; Humans; Lactic Acid; Prognosis; Retrospective Stud | 2023 |
Clinical application of BIS combined with LCR in assessing brain function and prognosis of patients with severe carbon monoxide poisoning.
Topics: Brain; Brain Injuries; Carbon Monoxide Poisoning; Humans; Lactic Acid; Prognosis; Retrospective Stud | 2023 |
Clinical application of BIS combined with LCR in assessing brain function and prognosis of patients with severe carbon monoxide poisoning.
Topics: Brain; Brain Injuries; Carbon Monoxide Poisoning; Humans; Lactic Acid; Prognosis; Retrospective Stud | 2023 |
Longitudinal perturbations of plasma nuclear magnetic resonance profiles in neonatal encephalopathy.
Topics: 3-Hydroxybutyric Acid; Biomarkers; Brain Injuries; Humans; Hypothermia, Induced; Hypoxia-Ischemia, B | 2023 |
Cerebro-spinal fluid glucose and lactate concentrations changes in response to therapies in patIents with primary brain injury: the START-TRIP study.
Topics: Adult; Brain Injuries; Glucose; Humans; Intracranial Pressure; Lactic Acid; Linear Models; Prospecti | 2023 |
Temporally Altered miRNA Expression in a Piglet Model of Hypoxic Ischemic Brain Injury.
Topics: Animals; Animals, Newborn; Biomarkers; Bone Morphogenetic Protein Receptors, Type II; Brain; Brain I | 2020 |
Lactate Administration Reduces Brain Injury and Ameliorates Behavioral Outcomes Following Neonatal Hypoxia-Ischemia.
Topics: Animals; Animals, Newborn; Brain; Brain Injuries; Disease Models, Animal; Female; Hypoxia; Hypoxia-I | 2020 |
Cerebral microdialysis in TBI-limitations and possibilities.
Topics: Brain Injuries; Humans; Intracranial Pressure; Lactic Acid; Microdialysis | 2017 |
A raised serum lactate level is an independent predictor of in-hospital mortality in patients with isolated cerebral gunshot wounds.
Topics: Adult; Brain Injuries; Emergency Service, Hospital; Female; Hospital Mortality; Humans; Lactic Acid; | 2018 |
Monitoring of Cerebral Metabolism in Postcardiac Arrest Patients: A Pilot Study.
Topics: Adult; Aged; Aged, 80 and over; Brain Injuries; Cerebrum; Female; Heart Arrest; Humans; Lactic Acid; | 2018 |
Impaired Cerebral Metabolism in Injured Brain: Can Lactate Step in for Glucose?
Topics: Brain; Brain Injuries; Cerebrovascular Circulation; Glucose; Humans; Lactic Acid | 2018 |
Consequence of insertion trauma - effect on early measurements when using intracerebral devices.
Topics: Animals; Brain; Brain Injuries; Glucose; Glycerol; Lactic Acid; Microdialysis; Prostheses and Implan | 2019 |
Neuromonitoring with microdialysis in severe traumatic brain injury patients.
Topics: Adolescent; Adult; Aged; Amino Acids; Biomarkers; Brain; Brain Injuries; Female; Glasgow Outcome Sca | 2013 |
Is there any association between cerebral vasoconstriction/vasodilatation and microdialysis Lactate to Pyruvate ratio increase?
Topics: Adult; Aged; Algorithms; Brain; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Female; | 2013 |
Application of PLGA/type I collagen/chitosan artificial composite dura mater in the treatment of dural injury.
Topics: Animals; Brain Injuries; Collagen Type I; Dura Mater; Lactic Acid; Polyglycolic Acid; Polylactic Aci | 2013 |
Impact of methamphetamine on regional metabolism and cerebral blood flow after traumatic brain injury.
Topics: Adolescent; Adult; Amphetamine-Related Disorders; Aspartic Acid; Brain; Brain Injuries; Central Nerv | 2013 |
Cerebral extracellular lactate increase is predominantly nonischemic in patients with severe traumatic brain injury.
Topics: Adult; Brain Injuries; Cerebral Cortex; Cerebrovascular Circulation; Cohort Studies; Extracellular S | 2013 |
Lactate uptake by the injured human brain: evidence from an arteriovenous gradient and cerebral microdialysis study.
Topics: Adolescent; Adult; Blood Glucose; Brain; Brain Injuries; Cerebral Arteries; Cerebrovascular Circulat | 2013 |
Lactate uptake against a concentration gradient: misinterpretation of analytical imprecision.
Topics: Brain; Brain Injuries; Cerebral Arteries; Cerebrovascular Circulation; Female; Humans; Jugular Veins | 2014 |
Response to letter "Lactate uptake against a concentration gradient: misinterpretation of analytical imprecision".
Topics: Brain; Brain Injuries; Cerebral Arteries; Cerebrovascular Circulation; Female; Humans; Jugular Veins | 2014 |
Blast neurotrauma impairs working memory and disrupts prefrontal myo-inositol levels in rats.
Topics: Animals; Betaine; Blast Injuries; Brain Injuries; Creatine; Ethanolamines; gamma-Aminobutyric Acid; | 2014 |
Is selective antegrade cerebral perfusion superior to retrograde cerebral perfusion for brain protection during deep hypothermic circulatory arrest? Metabolic evidence from microdialysis.
Topics: Analysis of Variance; Animals; Brain; Brain Injuries; Circulatory Arrest, Deep Hypothermia Induced; | 2014 |
Exogenous lactate supplementation to the injured brain: misleading conclusions with clinical implications.
Topics: Brain; Brain Injuries; Humans; Lactic Acid | 2014 |
Hypertonic lactate and the injured brain: facts and the potential for positive clinical implications.
Topics: Brain Injuries; Humans; Hypertonic Solutions; Lactic Acid | 2014 |
Lactate storm marks cerebral metabolism following brain trauma.
Topics: Acetic Acid; Animals; Astrocytes; Brain; Brain Injuries; Glial Fibrillary Acidic Protein; Glucose; G | 2014 |
Brain metabolic crisis in traumatic brain injury: what does it mean?
Topics: Brain; Brain Chemistry; Brain Injuries; Humans; Lactic Acid; Microdialysis; Pyruvic Acid | 2014 |
Lactate and the lactate-to-pyruvate molar ratio cannot be used as independent biomarkers for monitoring brain energetic metabolism: a microdialysis study in patients with traumatic brain injuries.
Topics: Adult; Biomarkers; Brain Injuries; Energy Metabolism; Female; Glucose; Humans; Lactic Acid; Male; Mi | 2014 |
Detecting brain injury in neonatal hypoxic ischemic encephalopathy: closing the gap between experimental and clinical research.
Topics: Analysis of Variance; Animals; Animals, Newborn; Blood Pressure; Brain Injuries; Disease Models, Ani | 2014 |
Cerebral Glucose Metabolism and Sedation in Brain-injured Patients: A Microdialysis Study.
Topics: Adult; Aged; Brain; Brain Injuries; Dose-Response Relationship, Drug; Female; Glucose; Glutamic Acid | 2015 |
Endogenous Nutritive Support after Traumatic Brain Injury: Peripheral Lactate Production for Glucose Supply via Gluconeogenesis.
Topics: Adolescent; Adult; Brain Injuries; Female; Gluconeogenesis; Glucose; Humans; Lactic Acid; Male; Midd | 2015 |
Glycolysis and the pentose phosphate pathway after human traumatic brain injury: microdialysis studies using 1,2-(13)C2 glucose.
Topics: Adolescent; Adult; Aged; Brain; Brain Injuries; Carbon Isotopes; Case-Control Studies; Female; Gluco | 2015 |
Lactate: brain fuel in human traumatic brain injury: a comparison with normal healthy control subjects.
Topics: Adolescent; Adult; Brain; Brain Injuries; Female; Humans; Lactic Acid; Male; Middle Aged; Young Adul | 2015 |
Curcumin, encapsulated in nano-sized PLGA, down-regulates nuclear factor κB (p65) and subarachnoid hemorrhage induced early brain injury in a rat model.
Topics: Analysis of Variance; Animals; Biocompatible Materials; Brain Injuries; Caspase 3; Caspase 9; Curcum | 2015 |
Neuroenergetic Response to Prolonged Cerebral Glucose Depletion after Severe Brain Injury and the Role of Lactate.
Topics: Adult; Blood Glucose; Brain; Brain Injuries; Female; Glucose; Humans; Lactic Acid; Male; Microdialys | 2015 |
Low-level light in combination with metabolic modulators for effective therapy of injured brain.
Topics: Animals; Brain Injuries; Cell Hypoxia; Cell Line, Tumor; Hippocampus; Humans; Lactic Acid; Light; Me | 2015 |
PLGA Nanoparticles Loaded Cerebrolysin: Studies on Their Preparation and Investigation of the Effect of Storage and Serum Stability with Reference to Traumatic Brain Injury.
Topics: Amino Acids; Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Delayed-Action Preparations; | 2015 |
Neuroprotective efficacy of decompressive craniectomy after controlled cortical impact injury in rats: An MRI study.
Topics: Animals; Aspartic Acid; Brain; Brain Edema; Brain Injuries; Choline; Creatine; Decompressive Craniec | 2015 |
Fueling the Brain--a New Role in Lactate Metabolism.
Topics: Brain; Brain Chemistry; Brain Injuries; Energy Metabolism; Humans; Lactic Acid; Nutritional Support | 2015 |
Polysorbate 80-coated PLGA nanoparticles improve the permeability of acetylpuerarin and enhance its brain-protective effects in rats.
Topics: Animals; Apoptosis; Area Under Curve; Biotransformation; Blood-Brain Barrier; Brain; Brain Injuries; | 2015 |
Effect of PLGA NP size on efficiency to target traumatic brain injury.
Topics: Animals; Benzenesulfonates; Brain; Brain Injuries; Cell Line, Tumor; Drug Carriers; Female; Fluoresc | 2016 |
Metabolic crisis occurs with seizures and periodic discharges after brain trauma.
Topics: Adult; Aged; Aged, 80 and over; Brain Injuries; Electroencephalography; Female; Humans; Lactic Acid; | 2016 |
Clinical research on postoperative efficacy and related factors of early simulation hyperbaric oxygen therapy for severe craniocerebral injury.
Topics: Adult; Age Factors; Aged; Blood Glucose; Brain Injuries; Computer Simulation; Critical Care; Female; | 2016 |
Neuroprotective actions of taurine on hypoxic-ischemic brain damage in neonatal rats.
Topics: Animals; Animals, Newborn; Apoptosis Inducing Factor; Brain Infarction; Brain Injuries; Female; Glut | 2016 |
Early rehabilitation aggravates brain damage after stroke via enhanced activation of nicotinamide adenine dinucleotide phosphate oxidase (NOX).
Topics: Animals; Apoptosis; Brain Injuries; Cerebral Cortex; Glucose Transporter Type 1; Glucose Transporter | 2016 |
Simultaneous monitoring of potassium, glucose and lactate during spreading depolarization in the injured human brain - Proof of principle of a novel real-time neurochemical analysis system, continuous online microdialysis.
Topics: Brain Injuries; Coma; Cortical Spreading Depression; Electrocorticography; Glucose; Humans; Lactic A | 2017 |
Hyperoxia results in increased aerobic metabolism following acute brain injury.
Topics: Blood Flow Velocity; Brain; Brain Injuries; Cerebrovascular Circulation; Cytochromes c; Energy Metab | 2017 |
Amyloid-beta dynamics correlate with neurological status in the injured human brain.
Topics: Amyloid beta-Peptides; Brain; Brain Injuries; Extracellular Fluid; Glasgow Coma Scale; Glucose; Huma | 2008 |
Persistent metabolic crisis as measured by elevated cerebral microdialysis lactate-pyruvate ratio predicts chronic frontal lobe brain atrophy after traumatic brain injury.
Topics: Adolescent; Adult; Atrophy; Biomarkers; Brain Diseases; Brain Injuries; Chronic Disease; Cohort Stud | 2008 |
Acute subdural hematoma in pigs: role of volume on multiparametric neuromonitoring and histology.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Evoked Potentials, Somatosensor | 2008 |
Nonischemic energy metabolic crisis in acute brain injury.
Topics: Biomarkers; Brain Injuries; Critical Care; Critical Illness; Energy Metabolism; Female; Glasgow Coma | 2008 |
Neuroprotective effects of erythropoietin on acute metabolic and pathological changes in experimentally induced neurotrauma.
Topics: Acute Disease; Animals; Brain Injuries; Disease Models, Animal; Energy Metabolism; Erythropoietin; G | 2008 |
Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury: a microdialysis study.
Topics: Adult; Aged; Blood Glucose; Brain; Brain Injuries; Female; Glucose; Hospitals, University; Humans; H | 2008 |
Effect of hypoperfusion and the protein C pathway on the early coagulopathy after traumatic brain injury.
Topics: Adult; Blood Coagulation Disorders; Brain Injuries; Brain Ischemia; Hemoperitoneum; Humans; Lactic A | 2008 |
A combined microdialysis and FDG-PET study of glucose metabolism in head injury.
Topics: Adolescent; Adult; Aged; Biomarkers; Brain; Brain Injuries; Energy Metabolism; Extracellular Fluid; | 2009 |
IFN-gamma and IL-4 differentially shape metabolic responses and neuroprotective phenotype of astrocytes.
Topics: Animals; Astrocytes; Brain; Brain Injuries; Cell Hypoxia; Cells, Cultured; Dose-Response Relationshi | 2009 |
Dual microdialysis probe monitoring for patients with traumatic brain injury.
Topics: Brain Injuries; Electrochemistry; Extracellular Space; Female; Glutamic Acid; Humans; Lactic Acid; M | 2008 |
Delayed cerebral oxidative glucose metabolism after traumatic brain injury in young rats.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Edema; Brain Injuries; Glucose; Glutamic Acid; Glutamine; | 2009 |
Adaptation to oxidative challenge induced by chronic physical exercise prevents Na+,K+-ATPase activity inhibition after traumatic brain injury.
Topics: Analysis of Variance; Animals; Body Weight; Brain Injuries; Cerebral Cortex; Lactic Acid; Male; Oxid | 2009 |
Improving the recovery of S100B protein in cerebral microdialysis: implications for multimodal monitoring in neurocritical care.
Topics: Brain Injuries; Catheterization; Enzyme-Linked Immunosorbent Assay; Extracellular Fluid; Glucose; Hu | 2009 |
Enzyme logic gates for the digital analysis of physiological level upon injury.
Topics: Biomarkers; Biosensing Techniques; Brain Injuries; Computers, Molecular; Diagnosis, Computer-Assiste | 2009 |
Metabolic and histologic effects of sodium pyruvate treatment in the rat after cortical contusion injury.
Topics: Analysis of Variance; Animals; Brain; Brain Injuries; Cell Count; Glucose; Lactic Acid; Male; Microd | 2009 |
The human brain utilizes lactate via the tricarboxylic acid cycle: a 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study.
Topics: Acetates; Adolescent; Adult; Brain; Brain Chemistry; Brain Injuries; Citric Acid Cycle; Energy Metab | 2009 |
Temporal and regional changes after focal traumatic brain injury.
Topics: Animals; Aspartic Acid; Brain; Brain Edema; Brain Injuries; Brain Mapping; Cerebral Cortex; Choline; | 2010 |
Brain tissue lactate elevations predict episodes of intracranial hypertension in patients with traumatic brain injury.
Topics: Adolescent; Adult; Aged; Area Under Curve; Australia; Biomarkers; Brain; Brain Injuries; Dermatitis, | 2009 |
Prognosis for severe traumatic brain injury patients treated with bilateral decompressive craniectomy.
Topics: Brain Injuries; Decompressive Craniectomy; Disability Evaluation; Female; Functional Laterality; Gla | 2010 |
Brain metabolism is significantly impaired at blood glucose below 6 mM and brain glucose below 1 mM in patients with severe traumatic brain injury.
Topics: Adolescent; Adult; Blood Glucose; Brain; Brain Injuries; Female; Glutamic Acid; Humans; Insulin; Int | 2010 |
Dynamic metabolic response to multiple spreading depolarizations in patients with acute brain injury: an online microdialysis study.
Topics: Adult; Aged; Area Under Curve; Brain; Brain Injuries; Craniotomy; Electroencephalography; Female; Gl | 2010 |
Metabolic crisis after traumatic brain injury is associated with a novel microdialysis proteome.
Topics: Blood Glucose; Brain; Brain Injuries; Brain Ischemia; Cerebral Hemorrhage, Traumatic; Energy Metabol | 2010 |
Traumatic brain injury and metabolism.
Topics: Blood Flow Velocity; Blood Glucose; Brain; Brain Injuries; Craniotomy; Decompression, Surgical; Ener | 2010 |
Moderate Ringer's lactate solution resuscitation yields best neurological outcome in controlled hemorrhagic shock combined with brain injury in rats.
Topics: Animals; Brain; Brain Injuries; Isotonic Solutions; Lactic Acid; Male; Rats; Rats, Inbred Lew; Ringe | 2010 |
Insulin differentially influences brain glucose and lactate in traumatic brain injured patients.
Topics: Adolescent; Adult; Blood Glucose; Brain Chemistry; Brain Injuries; Female; Glucose; Humans; Hypoglyc | 2010 |
[Is lactate a good indicator of brain tissue hypoxia in the acute phase of traumatic brain injury? Results of a pilot study in 21 patients].
Topics: Adult; Biomarkers; Brain Injuries; Diagnosis, Differential; Energy Metabolism; Glucose; Humans; Hypo | 2010 |
Post-traumatic hypoxia exacerbates brain tissue damage: analysis of axonal injury and glial responses.
Topics: Amyloid beta-Protein Precursor; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Bl | 2010 |
Metabolic effects of a late hypotensive insult combined with reduced intracranial compliance following traumatic brain injury in the rat.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Glycerol; Hypotension; Hypoxant | 2010 |
Cerebral lactic acid and phosphates in concussion.
Topics: Brain; Brain Concussion; Brain Injuries; Lactic Acid; Phosphates | 1946 |
Cerebral glucose metabolism after traumatic brain injury in the rat studied by 13C-glucose and microdialysis.
Topics: Anaerobiosis; Animals; Blood Glucose; Brain Damage, Chronic; Brain Injuries; Carbon Radioisotopes; E | 2011 |
Cerebral microdialysis in acutely brain-injured patients with spreading depolarizations.
Topics: Adult; Brain Injuries; Cerebral Cortex; Cortical Spreading Depression; Electroencephalography; Femal | 2011 |
Alterations in cerebral oxidative metabolism following traumatic brain injury.
Topics: Brain; Brain Injuries; Female; Humans; Lactic Acid; Microdialysis; Oxygen; Pyruvic Acid; Tomography, | 2011 |
Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients.
Topics: Adult; Biomarkers; Brain Injuries; Cerebral Cortex; Extracellular Fluid; Female; Glasgow Coma Scale; | 2011 |
Potential non-hypoxic/ischemic causes of increased cerebral interstitial fluid lactate/pyruvate ratio: a review of available literature.
Topics: Aerobiosis; Anaerobiosis; Blood Glucose; Brain; Brain Injuries; Critical Care; Energy Metabolism; Ex | 2011 |
Analysis of the changes in the oxidation of brain tissue cytochrome-c-oxidase in traumatic brain injury patients during hypercapnoea: a broadband NIRS study.
Topics: Adult; Brain; Brain Injuries; Electron Transport Complex IV; Female; Humans; Hypercapnia; Lactic Aci | 2011 |
Time course of recovery from cerebral vulnerability after severe traumatic brain injury: a microdialysis study.
Topics: Analysis of Variance; Biomarkers; Body Temperature; Brain Injuries; Extracellular Fluid; Female; Gla | 2011 |
Lower extracellular glucose level prolonged in elderly patients with severe traumatic brain injury: a microdialysis study.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Blood Glucose; Brain; Brain Chemistry; Brain Injuries; | 2011 |
Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats.
Topics: Animals; Brain Edema; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Dose-Response Relatio | 2011 |
Effects of a small acute subdural hematoma following traumatic brain injury on neuromonitoring, brain swelling and histology in pigs.
Topics: Animals; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; Evoked Po | 2011 |
Arterial lactate above 2 mM is associated with increased brain lactate and decreased brain glucose in patients with severe traumatic brain injury.
Topics: Adolescent; Adult; Arteries; Brain; Brain Injuries; Female; Glucose; Humans; Injury Severity Score; | 2012 |
Cerebral metabolism after early decompression craniotomy following controlled cortical impact injury in rats.
Topics: Animals; Brain Injuries; Cerebral Cortex; Craniotomy; Decompression, Surgical; Disease Models, Anima | 2011 |
Lactate: a friendly fuel for the injured brain?
Topics: Brain; Brain Injuries; Female; Glucose; Humans; Lactic Acid; Male | 2012 |
Brain tissue oxygenation and cerebral perfusion pressure thresholds of ischemia in a standardized pig brain death model.
Topics: Animals; Blood Pressure; Brain; Brain Death; Brain Injuries; Brain Ischemia; Catheterization; Cerebr | 2012 |
Early cerebral metabolic crisis after TBI influences outcome despite adequate hemodynamic resuscitation.
Topics: Adult; Blood Pressure; Brain; Brain Diseases, Metabolic; Brain Injuries; Cardiopulmonary Resuscitati | 2012 |
'Long' pressure reactivity index (L-PRx) as a measure of autoregulation correlates with outcome in traumatic brain injury patients.
Topics: Adult; Algorithms; Arterial Pressure; Blood Glucose; Brain; Brain Injuries; Disability Evaluation; F | 2012 |
The frontal lobe and thalamus have different sensitivities to hypoxia-hypotension after traumatic brain injury: a microdialysis study in rats.
Topics: Animals; Blood Pressure; Brain Injuries; Cerebrovascular Circulation; Energy Metabolism; Frontal Lob | 2012 |
Normobaric hyperoxia does not change optical scattering or pathlength but does increase oxidised cytochrome C oxidase concentration in patients with brain injury.
Topics: Adult; Aged; Brain Injuries; Cerebrovascular Circulation; Electron Transport Complex IV; Female; Hem | 2013 |
The neuroprotective effect of lactate is not due to improved glutamate uptake after controlled cortical impact in rats.
Topics: Animals; Brain Chemistry; Brain Injuries; Cerebral Cortex; Cerebrovascular Circulation; Chromatograp | 2012 |
Effects of the neurological wake-up test on clinical examination, intracranial pressure, brain metabolism and brain tissue oxygenation in severely brain-injured patients.
Topics: Adult; Brain; Brain Chemistry; Brain Injuries; Deep Sedation; Female; Glucose; Hemodynamics; Humans; | 2012 |
Changes in cerebral glycolytic activity during transport of critically ill neurotrauma patients measured with microdialysis.
Topics: Adolescent; Aged; Brain Injuries; Cerebral Cortex; Cerebrovascular Circulation; Critical Care; Criti | 2002 |
Traumatic brain injury and subarachnoid hemorrhage: in vivo occult pathology demonstrated by magnetic resonance spectroscopy may not be "ischaemic". A primary study and review of the literature.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Injuries; Brain Ischemia; Child; Choline; Creatine; C | 2002 |
Brain alkaline intracellular pH after neonatal encephalopathy.
Topics: Alkalosis; Analysis of Variance; Brain; Brain Injuries; Creatine; Follow-Up Studies; Humans; Hydroge | 2002 |
Correlation between blood glucose concentration and glucose concentration in subcutaneous adipose tissue evaluated with microdialysis during intensive care.
Topics: Adipose Tissue; Blood Glucose; Brain Injuries; Critical Care; Energy Metabolism; Glycerol; Humans; H | 2002 |
Does acute hyperventilation cause cerebral ischemia in severely head-injured patients?
Topics: Brain Injuries; Brain Ischemia; Glutamic Acid; Humans; Hyperventilation; Lactic Acid; Respiration, A | 2002 |
Effects of ganglioside GM1 on reduction of brain edema and amelioration of cerebral metabolism after traumatic brain injury.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Hexosyltransferases; Lactic Aci | 2003 |
Predicting neuropsychologic outcome after traumatic brain injury in children.
Topics: Adolescent; Adult; Brain Chemistry; Brain Injuries; Child; Child, Preschool; Electroencephalography; | 2003 |
Persistently low extracellular glucose correlates with poor outcome 6 months after human traumatic brain injury despite a lack of increased lactate: a microdialysis study.
Topics: Adult; Brain; Brain Injuries; Extracellular Space; Female; Glasgow Coma Scale; Glucose; Humans; Lact | 2003 |
Effects of LY379268, a selective group II metabotropic glutamate receptor agonist on EEG activity, cortical perfusion, tissue damage, and cortical glutamate, glucose, and lactate levels in brain-injured rats.
Topics: Amino Acids; Animals; Brain Edema; Brain Injuries; Bridged Bicyclo Compounds, Heterocyclic; Cerebral | 2003 |
L-glutamate decreases glucose utilization by rat cortical astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Brain Injuries; Cell Hypoxia; Cells, Cultured; Cerebral Corte | 2003 |
Metabolic changes in the vicinity of brain contusions: a proton magnetic resonance spectroscopy and histology study.
Topics: Animals; Aspartic Acid; Biomarkers; Brain Injuries; Choline; Creatine; Functional Laterality; Glutam | 2003 |
Energy dysfunction as a predictor of outcome after moderate or severe head injury: indices of oxygen, glucose, and lactate metabolism.
Topics: Adult; Brain; Brain Injuries; Cerebrovascular Circulation; Cohort Studies; Energy Metabolism; Female | 2003 |
Metabolic changes during impending and manifest cerebral hypoxia in traumatic brain injury.
Topics: Adolescent; Adult; Aged; Brain; Brain Injuries; Female; Glutamic Acid; Humans; Hypoxia, Brain; Lacti | 2003 |
Moderate controlled cortical contusion in pigs: effects on multi-parametric neuromonitoring and clinical relevance.
Topics: Animals; Body Temperature; Brain Edema; Brain Injuries; Disease Models, Animal; Glucose; Glutamic Ac | 2003 |
Creatine-enhanced diet alters levels of lactate and free fatty acids after experimental brain injury.
Topics: Animals; Brain; Brain Injuries; Creatine; Diet; Dietary Supplements; Dose-Response Relationship, Dru | 2004 |
Preoperative brain injury in newborns with transposition of the great arteries.
Topics: Brain Injuries; Cardiopulmonary Bypass; Choline; Gestational Age; Humans; Infant, Newborn; Lactic Ac | 2004 |
Assessment of jugular blood oxygen and lactate indices for detection of cerebral ischemia and prognosis.
Topics: Brain Injuries; Brain Ischemia; Coma; Glasgow Coma Scale; Humans; Intracranial Aneurysm; Jugular Vei | 2004 |
Effects of norepinephrine depletion in rats during cerebral post-ischemic reperfusion.
Topics: Animals; Benzylamines; Brain Chemistry; Brain Injuries; Brain Ischemia; Cerebral Cortex; Coloring Ag | 2004 |
In vivo neuroprotective adaptation of the glutamate/glutamine cycle to neuronal death.
Topics: Animals; Apoptosis; Brain; Brain Injuries; Cell Death; Cell Survival; Denervation; Disease Models, A | 2004 |
Patterns of energy substrates during ischemia measured in the brain by microdialysis.
Topics: Adult; Brain Injuries; Brain Ischemia; Female; Glasgow Coma Scale; Glucose; Glutamic Acid; Humans; H | 2004 |
Influence of oxygen therapy on glucose-lactate metabolism after diffuse brain injury.
Topics: Animals; Blood Gas Analysis; Blood Glucose; Blood Pressure; Body Temperature; Brain Injuries; Carbon | 2004 |
Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study.
Topics: Adolescent; Adult; Aged; Blood Glucose; Brain; Brain Injuries; Cohort Studies; Critical Care; Energy | 2004 |
Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study.
Topics: Adolescent; Adult; Aged; Blood Glucose; Brain; Brain Injuries; Cohort Studies; Critical Care; Energy | 2004 |
Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study.
Topics: Adolescent; Adult; Aged; Blood Glucose; Brain; Brain Injuries; Cohort Studies; Critical Care; Energy | 2004 |
Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study.
Topics: Adolescent; Adult; Aged; Blood Glucose; Brain; Brain Injuries; Cohort Studies; Critical Care; Energy | 2004 |
Cerebral vascular and metabolic response to sustained systemic inflammation in ovine traumatic brain injury.
Topics: Animals; Blood Glucose; Body Temperature; Brain; Brain Injuries; Carbon Dioxide; Cerebrovascular Cir | 2004 |
Gender associations with cerebrospinal fluid glutamate and lactate/pyruvate levels after severe traumatic brain injury.
Topics: Adult; Brain Injuries; Female; Glasgow Coma Scale; Glutamic Acid; Humans; Hypothermia, Induced; Lact | 2005 |
Seizures induced in immature rats by homocysteic acid and the associated brain damage are prevented by group II metabotropic glutamate receptor agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate.
Topics: Amino Acids; Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Brain; Brain Chemistry; B | 2005 |
Intracerebral microdialysis in severe brain trauma: the importance of catheter location.
Topics: Adult; Aged; Brain Injuries; Catheters, Indwelling; Child; Female; Glucose; Humans; Lactic Acid; Mal | 2005 |
Elevated lactate as an early marker of brain injury in inflicted traumatic brain injury.
Topics: Aspartic Acid; Brain Chemistry; Brain Injuries; Critical Care; Female; Fractures, Bone; Frontal Lobe | 2005 |
Detection of the inhibitory neurotransmitter GABA in macrophages by magnetic resonance spectroscopy.
Topics: Amino Acids; Animals; Biomarkers; Brain Injuries; Cell Communication; Cell Extracts; Cell Line; Cell | 2005 |
Effects of cocaine in an experimental model of traumatic brain injury.
Topics: Animals; Blood Pressure; Brain Injuries; Cardiac Output; Cerebrovascular Circulation; Cocaine-Relate | 2005 |
Concurrent monitoring of cerebral electrophysiology and metabolism after traumatic brain injury: an experimental and clinical study.
Topics: Action Potentials; Adult; Animals; Brain Diseases, Metabolic; Brain Injuries; Cerebral Cortex; Disea | 2005 |
[Effect of focal hypothermia on traumatic brain edema and the content of lactic acid in the brain tissue in rats].
Topics: Animals; Brain Edema; Brain Injuries; Hypothermia, Induced; Lactic Acid; Male; Random Allocation; Ra | 2004 |
Monitoring of cerebral blood flow and metabolism in traumatic brain injury.
Topics: Adult; Brain; Brain Injuries; Cerebrovascular Circulation; Glucose; Humans; Lactic Acid; Oxygen Cons | 2005 |
Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury.
Topics: Age Factors; Aging; Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Energy Metabol | 2005 |
Upregulation of pentose phosphate pathway and preservation of tricarboxylic acid cycle flux after experimental brain injury.
Topics: Animals; Brain Injuries; Citric Acid Cycle; Disease Models, Animal; Glucose; Glutamic Acid; Glutamin | 2005 |
Cerebral acid-base homeostasis after severe traumatic brain injury.
Topics: Acid-Base Equilibrium; Adult; Brain Chemistry; Brain Injuries; Carbon Dioxide; Cell Death; Female; H | 2005 |
Intracerebral microdialysis in neurosurgical intensive care patients utilising catheters with different molecular cut-off (20 and 100 kD).
Topics: Brain Chemistry; Brain Injuries; Catheters, Indwelling; Cerebral Cortex; Coma; Critical Care; Extrac | 2006 |
[Influence of temperature on extracellular glucose and lactate after traumatic brain injury].
Topics: Adult; Body Temperature; Brain Injuries; Extracellular Space; Female; Glucose; Humans; Lactic Acid; | 2006 |
Quantitation of ischemic events after severe traumatic brain injury in humans: a simple scoring system.
Topics: Adult; Age Factors; Brain Chemistry; Brain Injuries; Brain Ischemia; Extracellular Fluid; Female; Gl | 2006 |
Increased lactate levels impair the coagulation system--a potential contributing factor to progressive hemorrhage after traumatic brain injury.
Topics: Acidosis; Blood Coagulation; Brain Injuries; Buffers; Cerebral Hemorrhage, Traumatic; Disease Progre | 2006 |
Low intracranial compliance increases the impact of intracranial volume insults to the traumatized brain: a microdialysis study in a traumatic brain injury rodent model.
Topics: Animals; Biomarkers; Brain; Brain Chemistry; Brain Edema; Brain Injuries; Cell Membrane; Cerebral He | 2006 |
High extracellular potassium and its correlates after severe head injury: relationship to high intracranial pressure.
Topics: Adolescent; Adult; Astrocytes; Brain; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Cran | 2000 |
Activin a release into cerebrospinal fluid in a subset of patients with severe traumatic brain injury.
Topics: Activins; Adolescent; Adult; Aged; Brain Injuries; Case-Control Studies; Female; Follistatin; Glutam | 2006 |
Lactate, not glucose, up-regulates mitochondrial oxygen consumption both in sham and lateral fluid percussed rat brains.
Topics: Animals; Brain; Brain Injuries; Cell Respiration; Dose-Response Relationship, Drug; Glucose; Lactic | 2006 |
Pericontusional brain tissue exhibits persistent elevation of lactate/pyruvate ratio independent of cerebral perfusion pressure.
Topics: Adolescent; Adult; Biomarkers; Brain; Brain Injuries; Cerebrovascular Circulation; Female; Glasgow C | 2007 |
Heart sensitivity to electrolyte composition of perfusion solution of rats after severe brain injury.
Topics: Animals; Blood Glucose; Blood Pressure; Brain Injuries; Calcium; Electrolytes; Hydrogen-Ion Concentr | 2006 |
Synthes Award For Resident Research On Craniofacial And Brain Injury: effect of cyclosporin A, topiramate, or 100% oxygen as proposed "neuroprotective" therapies on the neurochemical analytes in patients with severe traumatic brain injury.
Topics: Adult; Awards and Prizes; Brain Injuries; Case-Control Studies; Cohort Studies; Cyclosporine; Fructo | 2006 |
Sleeping Beauty: a tale still with an uncertain happy ending after head trauma.
Topics: Biomarkers; Brain; Brain Injuries; Cerebrovascular Circulation; Glasgow Coma Scale; Hospitals, Unive | 2007 |
Identifying traumatic brain injury in patients with isolated head trauma: are arterial lactate and base deficit as helpful as in polytrauma?
Topics: Acid-Base Imbalance; Adult; Biomarkers; Brain Injuries; Cohort Studies; Female; Humans; Lactic Acid; | 2007 |
Changes in cortical and subcortical energy metabolism after repetitive and single controlled cortical impact injury in the mouse.
Topics: Adenosine Triphosphate; Animals; Brain Injuries; Cerebral Cortex; Energy Metabolism; Glucose; Lactic | 2007 |
Effect of brain cooling on brain ischemia and damage markers after fluid percussion brain injury in rats.
Topics: Animals; Behavior, Animal; Blood Pressure; Body Weight; Brain; Brain Injuries; Brain Ischemia; Cereb | 2007 |
The fate of glucose during the period of decreased metabolism after fluid percussion injury: a 13C NMR study.
Topics: Animals; Brain Injuries; Carbon Isotopes; Cerebral Cortex; Down-Regulation; Free Radicals; Glucose; | 2007 |
Poly(epsilon-caprolactone) and poly (L-lactic-co-glycolic acid) degradable polymer sponges attenuate astrocyte response and lesion growth in acute traumatic brain injury.
Topics: Absorbable Implants; Animals; Astrocytes; Biocompatible Materials; Brain Injuries; Female; Lactic Ac | 2007 |
Effect of lactate therapy upon cognitive deficits after traumatic brain injury in the rat.
Topics: Adenosine Triphosphate; Animals; Brain Injuries; Cerebral Cortex; Cognition; Cognition Disorders; In | 2007 |
Online correlation of spontaneous arterial and intracranial pressure fluctuations in patients with diffuse severe head injury.
Topics: Adolescent; Adult; Aged; Arteries; Blood Pressure; Brain Injuries; Female; Glucose; Humans; Intracra | 2007 |
Cerebral arterio-venous pCO2 difference, estimated respiratory quotient, and early posttraumatic outcome: comparison with arterio-venous lactate and oxygen differences.
Topics: Adult; Brain Death; Brain Injuries; Brain Ischemia; Carbon Dioxide; Cerebrovascular Circulation; Fem | 2007 |
Posttraumatic brain vulnerability to hypoxia-hypotension: the importance of the delay between brain trauma and secondary insult.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; Gl | 2008 |
Effect of hyperoxia on regional oxygenation and metabolism after severe traumatic brain injury: preliminary findings.
Topics: Adolescent; Adult; Brain Injuries; Cerebrum; Female; Humans; Hyperoxia; Intracranial Pressure; Lacti | 2008 |
Metabolic failure precedes intracranial pressure rises in traumatic brain injury: a microdialysis study.
Topics: Biomarkers; Brain; Brain Injuries; Glutamic Acid; Glycerol; Humans; Intracranial Hypertension; Lacti | 2008 |
Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats.
Topics: Aging; Alanine; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Injuries; Cell Respiration; C | 2008 |
[Effect of therapeutic hyperventilation on blood lactate concentration].
Topics: Adult; Aged; Brain Injuries; Carbon Dioxide; Child; Child, Preschool; Female; Humans; Lactates; Lact | 1983 |
[Role of cerebrospinal fluid lactic acid in the evaluation of cranial injuries. Review of the literature].
Topics: Brain Injuries; Glucose; Humans; Lactates; Lactic Acid; Prognosis; Pulmonary Gas Exchange | 1984 |
Neurochemical monitoring and on-line pH measurements using brain microdialysis in patients in intensive care.
Topics: Acid-Base Equilibrium; Adult; Ascorbic Acid; Blood Glucose; Blood-Brain Barrier; Brain Edema; Brain | 1994 |
Regional levels of lactate and norepinephrine after experimental brain injury.
Topics: Adenosine Triphosphate; Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Freezing; | 1994 |
Cerebral lactate-oxygen index in acute brain injury with acute anemia: assessment of false versus true ischemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Anemia; Brain; Brain Injuries; Brain Ischemia; Cerebrovascul | 1994 |
Lactated Ringer's solution alleviates brain trauma-precipitated lactic acidosis in hemorrhagic shock.
Topics: Acidosis, Lactic; Animals; Blood Glucose; Brain Injuries; Cerebral Hemorrhage; Gases; Hydrogen-Ion C | 1993 |
Early ischaemia after severe head injury. Preliminary results in patients with diffuse brain injuries.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Flow Velocity; Brain; Brain Concussion; Brain Dama | 1993 |
Immunohistochemical studies with antibodies to neurofilament proteins on axonal damage in experimental focal lesions in rat.
Topics: Animals; Axons; Biomarkers; Brain Injuries; Cerebral Infarction; Immunoenzyme Techniques; Lactates; | 1993 |
Cerebral extraction of oxygen, lactate production, and perfusion pressure in gunshot wound to the head: case report.
Topics: Adult; Blood Gas Analysis; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Humans; Lact | 1996 |
Proton MR spectroscopy after acute central nervous system injury: outcome prediction in neonates, infants, and children.
Topics: Adolescent; Aspartic Acid; Brain; Brain Diseases; Brain Injuries; Child; Choline; Discriminant Analy | 1997 |
Effects of six weeks of chronic ethanol administration on lactic acid accumulation and high energy phosphate levels after experimental brain injury in rats.
Topics: Adenosine Triphosphate; Animals; Body Weight; Brain; Brain Injuries; Central Nervous System Depressa | 1997 |
Comparison of brain tissue oxygen tension to microdialysis-based measures of cerebral ischemia in fatally head-injured humans.
Topics: Adult; Brain; Brain Death; Brain Injuries; Cations; Chromatography, High Pressure Liquid; Excitatory | 1998 |
Involvement of reactive oxygen species in membrane phospholipid breakdown and energy perturbation after traumatic brain injury in the rat.
Topics: Analysis of Variance; Animals; Biomarkers; Brain Injuries; Disease Models, Animal; Disease Progressi | 1998 |
Magnetic resonance spectroscopy of diffuse brain trauma in the pig.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Axons; Behavior, Animal; Brain Chemistry; Brain Inju | 1998 |
Amphetamine administration improves neurochemical outcome of lateral fluid percussion brain injury in the rat.
Topics: Animals; Brain Chemistry; Brain Injuries; Central Nervous System Stimulants; Dextroamphetamine; Fatt | 1998 |
Cerebral hemodynamic changes during sustained hypocapnia in severe head injury: can hyperventilation cause cerebral ischemia?
Topics: Adolescent; Adult; Brain; Brain Injuries; Brain Ischemia; Carbon Dioxide; Female; Hemodynamics; Home | 1998 |
Significance of multimodal cerebral monitoring under moderate therapeutic hypothermia for severe head injury.
Topics: Adolescent; Adult; Aged; Blood Flow Velocity; Brain; Brain Edema; Brain Injuries; Child; Child, Pres | 1998 |
Brain ischemia detected by tissue-PO2 measurement and the lactate-oxygen index in head injury.
Topics: Brain; Brain Concussion; Brain Injuries; Brain Ischemia; Humans; Lactic Acid; Oxygen; Oxygen Consump | 1998 |
Jugular bulb monitoring of cerebral oxygen metabolism in severe head injury: accuracy of unilateral measurements.
Topics: Brain; Brain Injuries; Brain Ischemia; Coma; Dominance, Cerebral; Female; Humans; Jugular Veins; Lac | 1998 |
Does growth hormone augment brain edema caused by brain injury? A study with a freeze brain injury model in the rat.
Topics: Animals; Blood Glucose; Body Water; Brain Chemistry; Brain Edema; Brain Injuries; Disease Models, An | 1999 |
Regional changes in cerebral extracellular glucose and lactate concentrations following severe cortical impact injury and secondary ischemia in rats.
Topics: Acidosis, Lactic; Animals; Blood Gas Analysis; Body Temperature; Brain Chemistry; Brain Injuries; Br | 1999 |
Extracellular lactate and glucose alterations in the brain after head injury measured by microdialysis.
Topics: Adult; Analysis of Variance; Brain Injuries; Cerebral Cortex; Cerebrovascular Circulation; Female; G | 1999 |
Lactate and traumatic brain injury.
Topics: Brain Injuries; Humans; Jugular Veins; Lactic Acid; Magnetic Resonance Spectroscopy; Microdialysis; | 1999 |
[Transcranial cytokine gradient and intestinal permeability in acute severe brain injury].
Topics: Adult; Brain Injuries; Cytokines; Female; Humans; Interleukin-1; Interleukin-6; Intestinal Mucosa; L | 1999 |
Secondary neurologic injury resulting from nonhypotensive hemorrhage combined with mild traumatic brain injury.
Topics: Animals; Blood Glucose; Brain Hemorrhage, Traumatic; Brain Injuries; Female; Hypotension; Intracrani | 1999 |
Brain tissue oxygenation.
Topics: Blood Glucose; Brain; Brain Injuries; Energy Metabolism; Extracellular Space; Humans; Lactic Acid; O | 1999 |
Glucose and lactate metabolism after severe human head injury: influence of excitatory neurotransmitters and injury type.
Topics: Adult; Brain Injuries; Female; Glasgow Coma Scale; Glucose; Glutamic Acid; Humans; Lactic Acid; Male | 1999 |
Evidence for time-dependent glutamate-mediated glycolysis in head-injured patients: a microdialysis study.
Topics: Adult; Brain Injuries; Female; Glasgow Coma Scale; Glucose; Glutamic Acid; Glycolysis; Humans; Lacti | 1999 |
Determinants of cerebral extracellular potassium after severe human head injury.
Topics: Adolescent; Adult; Biomarkers; Brain; Brain Injuries; Extracellular Space; Female; Glasgow Coma Scal | 1999 |
Effect of hypocapnea on CBF and extracellular intermediates of secondary brain injury.
Topics: Brain; Brain Injuries; Carbon Dioxide; Chromatography, High Pressure Liquid; Extracellular Space; Gl | 1999 |
Continuous monitoring of cerebrospinal fluid acid-base balance and oxygen metabolism in patients with severe head injury: pathophysiology and treatments for cerebral acidosis and ischemia.
Topics: Acidosis; Adolescent; Adult; Brain Injuries; Brain Ischemia; Carbon Dioxide; Fever; Glasgow Coma Sca | 1999 |
Monitoring by subcutaneous microdialysis in neurosurgical intensive care.
Topics: Adolescent; Aged; Blood Glucose; Brain Injuries; Chromatography, High Pressure Liquid; Female; Gluta | 1999 |
Peripheral plasma amino acid abnormalities in rehabilitation patients with severe brain injury.
Topics: Adolescent; Adult; Aged; Amino Acids; Biomarkers; Brain Injuries; Carnitine; Disability Evaluation; | 2000 |
Brain lactate uptake increases at the site of impact after traumatic brain injury.
Topics: Animals; Blood-Brain Barrier; Brain Injuries; Cerebral Cortex; Hippocampus; Lactic Acid; Male; Rats; | 2000 |
Microdialysis-based long-term measurements of energy-related metabolites in the rat brain following a fluid percussion trauma.
Topics: Animals; Brain Chemistry; Brain Injuries; Cerebral Cortex; Energy Metabolism; Extracellular Space; G | 2000 |
Cerebral oxygenation and systemic trauma related factors determining neurological outcome after brain injury.
Topics: Adolescent; Adult; APACHE; Brain Injuries; Catheterization, Peripheral; Female; Glasgow Coma Scale; | 2000 |
Clinical cerebral microdialysis: a methodological study.
Topics: Adult; Blood Glucose; Brain Chemistry; Brain Injuries; Catheters, Indwelling; Chromatography, High P | 2000 |
The impact of hypercarbia on the evolution of brain injury in a porcine model of traumatic brain injury and systemic hemorrhage.
Topics: Animals; Axons; Blood Pressure; Brain; Brain Injuries; Brain Ischemia; Carbon Dioxide; Cardiac Outpu | 2001 |
Interstitial brain adenosine and xanthine increase during jugular venous oxygen desaturations in humans after traumatic brain injury.
Topics: Adenosine; Adolescent; Adult; Blood Gas Analysis; Blood Glucose; Brain Chemistry; Brain Injuries; Ce | 2001 |
Effects of magnesium sulfate on tissue lactate and malondialdehyde levels in experimental head trauma.
Topics: Analysis of Variance; Animals; Brain; Brain Injuries; Female; Lactic Acid; Lipid Peroxidation; Magne | 2001 |
Changes in regional energy metabolism after closed head injury in the rat.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Injuries; Brain Ischemia; Encephalitis; Energy Metabol | 2001 |
17beta-Estradiol reduces cortical lesion size in the glutamate excitotoxicity model by enhancing extracellular lactate: a new neuroprotective pathway.
Topics: Animals; Brain Injuries; Cerebral Cortex; Cerebral Infarction; Disease Models, Animal; Estradiol; Ex | 2001 |
Effects of ethanol and naltrexone in a model of traumatic brain injury with hemorrhagic shock.
Topics: Animals; Blood Pressure; Brain; Brain Injuries; Cardiac Output; Ethanol; Hydrogen-Ion Concentration; | 2001 |
Interstitial lactate in the peritraumatic penumbra of rat brain.
Topics: Animals; Brain Damage, Chronic; Brain Edema; Brain Injuries; Cerebral Cortex; Lactic Acid; Male; Nec | 2000 |
Low extracellular (ECF) glucose affects the neurochemical profile in severe head-injured patients.
Topics: Blood Glucose; Brain; Brain Edema; Brain Injuries; Carbon Dioxide; Critical Care; Energy Metabolism; | 2000 |
On-line monitoring of substrate delivery and brain metabolism in head injury.
Topics: Adolescent; Adult; Aged; Blood Glucose; Brain Injuries; Catheters, Indwelling; Energy Metabolism; Fe | 2000 |
Substrate delivery and ionic balance disturbance after severe human head injury.
Topics: Acid-Base Equilibrium; Brain; Brain Edema; Brain Injuries; Carbon Dioxide; Glutamic Acid; Humans; La | 2000 |
Induced mitochondrial failure in the feline brain: implications for understanding acute post-traumatic metabolic events.
Topics: Animals; Brain; Brain Injuries; Carbon Dioxide; Cats; Cerebrovascular Circulation; Energy Metabolism | 2001 |
Brain energy metabolism during controlled reduction of cerebral perfusion pressure in severe head injuries.
Topics: Adolescent; Adult; Aged; Biomarkers; Brain Injuries; Cerebrovascular Circulation; Child; Child, Pres | 2001 |
Intracerebral microdialysis and bedside biochemical analysis in patients with fatal traumatic brain lesions.
Topics: Adult; Aged; Brain; Brain Injuries; Brain Ischemia; Energy Metabolism; Female; Glucose; Glycerol; Hu | 2001 |
Lactate reduces glutamate-induced neurotoxicity in rat cortex.
Topics: Animals; Brain Injuries; Cerebral Cortex; Drug Interactions; Extracellular Space; Glucose; Glutamic | 2001 |
Monitoring arterio-venous differences of glucose and lactate in the anesthetized rat with or without brain damage with ultrafiltration and biosensor technology.
Topics: Anesthetics; Animals; Arteries; Biosensing Techniques; Blood Glucose; Brain; Brain Injuries; Cerebro | 2001 |
Lactate administration attenuates cognitive deficits following traumatic brain injury.
Topics: Animals; Brain Chemistry; Brain Injuries; Cell Death; Cognition Disorders; Energy Metabolism; Hippoc | 2002 |
Relationship between brain temperature, brain chemistry and oxygen delivery after severe human head injury: the effect of mild hypothermia.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Body Temperature; Brain; Brain Chemistry; Brain Injuries; Ca | 2002 |
Correlation between cerebral blood flow, substrate delivery, and metabolism in head injury: a combined microdialysis and triple oxygen positron emission tomography study.
Topics: Adolescent; Adult; Brain; Brain Chemistry; Brain Injuries; Cerebrovascular Circulation; Female; Gluc | 2002 |
Indomethacin (Confortid) in severe head injury and elevated intracranial pressure (ICP).
Topics: Adult; Blood Pressure; Body Temperature Regulation; Brain; Brain Injuries; Drug Administration Sched | 1992 |
Estimating energy expenditure in traumatic brain injury: comparison of indirect calorimetry with predictive formulas.
Topics: Adult; Blood Glucose; Blood Urea Nitrogen; Brain Injuries; Calorimetry, Indirect; Energy Intake; Ene | 1992 |
Intravenous fluid tonicity: effect on intracranial pressure, cerebral blood flow, and cerebral oxygen delivery in focal brain injury.
Topics: Animals; Brain Injuries; Cerebrovascular Circulation; Hypotonic Solutions; Intracranial Pressure; Is | 1992 |
The effect of age on glucose-modulated cerebral agonal glycolytic rates measured in vivo by 1H NMR spectroscopy.
Topics: Age Factors; Animals; Animals, Newborn; Blood Glucose; Brain; Brain Injuries; Brain Ischemia; Glycol | 1991 |
[Study of the changes in carbohydrate metabolism as a diagnostic test of acute hypothalamic syndrome in severe cranio-cerebral trauma].
Topics: Acid-Base Equilibrium; Acidosis; Acute Disease; Adolescent; Adult; Brain Injuries; Carbohydrate Meta | 1990 |
The effects of indomethacin on intracranial pressure, cerebral blood flow and cerebral metabolism in patients with severe head injury and intracranial hypertension.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Body Temperature; Brain; Brain Injuries; Cerebrovascular | 1991 |
[Enzymes and metabolic products in the cerebrospinal fluid in acute craniocerebral trauma].
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Brain Injuries; Cerebrospinal Fluid; Clini | 1989 |
Effects of hyperventilation, hypothermia, and altered blood viscosity on cerebral blood flow, cross-brain oxygen extraction, and cerebral metabolic rate for oxygen in cats.
Topics: Animals; Blood Viscosity; Brain Injuries; Cats; Cerebrovascular Circulation; Hyperventilation; Hypot | 1989 |
Production and clearance of lactate from brain tissue, cerebrospinal fluid, and serum following experimental brain injury.
Topics: Animals; Arteries; Blood Glucose; Brain; Brain Injuries; Cats; Female; Lactates; Lactic Acid; Magnet | 1988 |
[Value of clinico-chemical studies of ventricular cerebrospinal fluid in patients with severe craniocerebral trauma].
Topics: Brain Damage, Chronic; Brain Injuries; Humans; Lactates; Lactic Acid; Prognosis | 1987 |
The predictive value of cerebral anaerobic metabolism with cerebral infarction after head injury.
Topics: Adult; Brain; Brain Injuries; Cerebral Infarction; Cerebrovascular Circulation; Female; Humans; Lact | 1987 |
Hyperglycemia, cerebrospinal fluid lactic acidosis, and cerebral blood flow in severely head-injured patients.
Topics: Acidosis; Adult; Blood Glucose; Brain; Brain Injuries; Cerebrovascular Circulation; Coma; Humans; Hy | 1987 |
Traumatic brain injury in the rat: alterations in brain lactate and pH as characterized by 1H and 31P nuclear magnetic resonance.
Topics: Animals; Brain; Brain Injuries; Cerebral Hemorrhage; Hemodynamics; Hydrogen-Ion Concentration; Intra | 1987 |
[Lactate concentration in the ventricular fluid and blood plasma following severe craniocerebral trauma].
Topics: Adult; Brain Injuries; Brain Ischemia; Coma; Female; Humans; Hypoxia, Brain; Intracranial Pressure; | 1985 |
[Multiple injury and severe multiple injury (remarks on definition and pathophysiology].
Topics: Abdominal Injuries; Adolescent; Adult; Aged; Blood Coagulation Factors; Brain Injuries; Child; Child | 1985 |