Page last updated: 2024-10-17

lactic acid and Acute Brain Injuries

lactic acid has been researched along with Acute Brain Injuries in 269 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"The present study has examined the anticonvulsant and neuroprotective effect of group II metabotropic glutamate receptor (mGluR) agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC) in the model of seizures induced in immature 12-day-old rats by bilateral intracerebroventricular infusion of dl-homocysteic acid (DL-HCA, 600 nmol/side)."7.73Seizures induced in immature rats by homocysteic acid and the associated brain damage are prevented by group II metabotropic glutamate receptor agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate. ( Druga, R; Folbergrová, J; Haugvicová, R; Kubová, H; Mares, P; Otáhal, J, 2005)
"Objective To investigate the effect of focal hypothermia (LH) on traumatic brain edema and the content of lactic acid in rat brain tissue."7.72[Effect of focal hypothermia on traumatic brain edema and the content of lactic acid in the brain tissue in rats]. ( Li, CH; Liang, YM; Liu, YS; Qu, HT; Wang, GW, 2004)
"Lisuride is a dopaminergic agonist with additional serotoninergic, adrenergic, and glutamate antagonistic properties."5.37Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats. ( Kiening, KL; Sakowitz, OW; Simunovic, F; Unterberg, AW; Zweckberger, K, 2011)
"Hyperglycemia was found consistently within 12 hours after injury (224 +/- 98 mg/dl, P less than 0."5.27Hyperglycemia, cerebrospinal fluid lactic acidosis, and cerebral blood flow in severely head-injured patients. ( De Salles, AA; Muizelaar, JP; Young, HF, 1987)
" Despite the use of barbiturate coma in patients with refractory intracranial hypertension, persistent release or impaired uptake of glutamate may be associated with continuous anaerobic metabolism, as shown by increases in cerebrospinal fluid hypoxanthine and lactate levels."5.09Thiopental attenuates energetic impairment but fails to normalize cerebrospinal fluid glutamate in brain-injured patients. ( Kossmann, T; Morganti-Kossmann, MC; Pleines, UE; Stocker, R; Stover, JF, 1999)
" This review discusses 3 issues that concern homeostasis in the acute care of trauma patients directly related to the stress response: hyperglycemia, lactic acidosis, and hypothermia."4.89Trauma and aggressive homeostasis management. ( Baranov, D; Neligan, PJ, 2013)
"Three important issues concerning homeostasis in the acute care of trauma patients that are related directly to the stress response are hyperglycemia, lactic acidosis, and hypothermia."4.84Trauma and aggressive homeostasis management. ( Baranov, D; Neligan, P, 2007)
"An LP ratio >25 and glycerol >100 micromol/L, but not glutamate >12 micromol/L, were associated with significantly higher risk of imminent intracranial hypertension (odds ratio: 9."3.74Metabolic failure precedes intracranial pressure rises in traumatic brain injury: a microdialysis study. ( Belli, A; Kitchen, N; Petzold, A; Russo, S; Sen, J; Smith, M, 2008)
"The present study has examined the anticonvulsant and neuroprotective effect of group II metabotropic glutamate receptor (mGluR) agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC) in the model of seizures induced in immature 12-day-old rats by bilateral intracerebroventricular infusion of dl-homocysteic acid (DL-HCA, 600 nmol/side)."3.73Seizures induced in immature rats by homocysteic acid and the associated brain damage are prevented by group II metabotropic glutamate receptor agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate. ( Druga, R; Folbergrová, J; Haugvicová, R; Kubová, H; Mares, P; Otáhal, J, 2005)
"Objective To investigate the effect of focal hypothermia (LH) on traumatic brain edema and the content of lactic acid in rat brain tissue."3.72[Effect of focal hypothermia on traumatic brain edema and the content of lactic acid in the brain tissue in rats]. ( Li, CH; Liang, YM; Liu, YS; Qu, HT; Wang, GW, 2004)
" Infarcts in substantia nigra pars reticulata were evoked by prolonged pilocarpine-induced status epilepticus."3.68Immunohistochemical studies with antibodies to neurofilament proteins on axonal damage in experimental focal lesions in rat. ( Bellander, BM; Ingvar, M; Meller, D; Schmidt-Kastner, R, 1993)
" It was revealed that alterations in carbohydrate metabolism in the form of lactic acidosis and anaerobiosis developed not only because of hemodynamic and ventilatory disorders."3.68[Study of the changes in carbohydrate metabolism as a diagnostic test of acute hypothalamic syndrome in severe cranio-cerebral trauma]. ( Borshchagovskiĭ, ML; Krauze, VE; Kuznetsova, VM; Raĭkhinshteĭn, VE, 1990)
"Mean Glasgow Coma Scale (GCS) score was 7 (range 4-10)."2.72Intracerebral microdialysis and intracranial compliance monitoring of patients with traumatic brain injury. ( Contant, CF; Enblad, P; Howells, T; Nilsson, P; Piper, I; Ronne-Engström, E; Salci, K, 2006)
" It was the purpose of this study to develop pharmacokinetic and pharmacodynamic models for determination of a dose for a pivotal Phase III clinical trial of DCA in patients with traumatic brain injury (TBI)."2.70Dichloroacetate: population pharmacokinetics with a pharmacodynamic sequential link model. ( Capparelli, EV; Dziewanowska, Z; Fox, AW; Lane, JR; Turkel, CC; Williams, PJ, 2001)
"For better care of postcardiac arrest patients, objective serial assessments of brain injury severity are needed."1.48Monitoring of Cerebral Metabolism in Postcardiac Arrest Patients: A Pilot Study. ( Chae, MK; Kang, SY; Lee, SE; Sim, MS, 2018)
"In TBI patients, seizures and periodic discharges are one mechanism for metabolic crisis, and hence represent a therapeutic target for future study."1.43Metabolic crisis occurs with seizures and periodic discharges after brain trauma. ( Buitrago-Blanco, M; Claassen, J; McArthur, D; Nuwer, M; Prins, M; Tu, B; Tubi, M; Velazquez, AG; Vespa, P, 2016)
"Taurine is an abundant amino acid in the nervous system, which has been proved to possess antioxidation, osmoregulation and membrane stabilization."1.43Neuroprotective actions of taurine on hypoxic-ischemic brain damage in neonatal rats. ( Hao, YJ; Li, YX; Ma, PS; Niu, Y; Sun, T; Wu, W; Yu, JQ; Zhou, R; Zhu, XY, 2016)
" The effect of LLL was further bolstered by combination with metabolic substrates such as pyruvate or lactate both in vivo and in vitro."1.42Low-level light in combination with metabolic modulators for effective therapy of injured brain. ( Dong, T; Hamblin, MR; Wu, MX; Zhang, Q, 2015)
"Acetylpuerarin (AP) is an acetylated derivative of puerarin (PUE)."1.42Polysorbate 80-coated PLGA nanoparticles improve the permeability of acetylpuerarin and enhance its brain-protective effects in rats. ( Lou, H; Shi, H; Sun, D; Xue, A; Zhang, B; Zhang, X, 2015)
"Lisuride is a dopaminergic agonist with additional serotoninergic, adrenergic, and glutamate antagonistic properties."1.37Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats. ( Kiening, KL; Sakowitz, OW; Simunovic, F; Unterberg, AW; Zweckberger, K, 2011)
"Anesthetized rats were assigned to sham; brain injury (BI); controlled hemorrhagic shock (CHS); BI combined with CHS (combined injury [CI]); and CI groups resuscitated with 2."1.36Moderate Ringer's lactate solution resuscitation yields best neurological outcome in controlled hemorrhagic shock combined with brain injury in rats. ( Brotfain, EM; Dar, DE; Krausz, MM; Leibowitz, A; Semenikhina, L; Shapira, Y; Solopov, A; Soustiel, JF; Zaaroor, M, 2010)
"Hypotension was induced 2 h after trauma."1.36Metabolic effects of a late hypotensive insult combined with reduced intracranial compliance following traumatic brain injury in the rat. ( Contant, CF; Enblad, P; Goiny, M; Nilsson, P; Piper, I; Salci, K, 2010)
"In addition, the TBI-induced cerebral infarction, motor and proprioception deficits, and body weight loss evaluated 3 days after TBI were significantly attenuated by brain cooling."1.34Effect of brain cooling on brain ischemia and damage markers after fluid percussion brain injury in rats. ( Chang, CP; Chio, CC; Hsiao, SH; Kuo, JR; Lin, MT, 2007)
"No lactic acidosis was induced by the intravenous infusion of 280 mM L-lactate."1.34Effect of lactate therapy upon cognitive deficits after traumatic brain injury in the rat. ( Bullock, MR; Hamm, RJ; Harvey, HB; Holloway, R; Levasseur, JE; Rice, AC; Sun, D; Zhou, Z, 2007)
"Early brain death (within 48 h) was assumed to be due to early global ischemia."1.34Cerebral arterio-venous pCO2 difference, estimated respiratory quotient, and early posttraumatic outcome: comparison with arterio-venous lactate and oxygen differences. ( Chieregato, A; Fainardi, E; Marchi, M; Targa, L, 2007)
"These four children all had seizure activity and abnormal initial neurological examinations and required admission to the PICU."1.33Elevated lactate as an early marker of brain injury in inflicted traumatic brain injury. ( Ball, WS; Care, M; Cecil, KM; Makoroff, KL, 2005)
"Cerebral ischemia is recognized as one of the most important mechanisms responsible for secondary brain damage following severe traumatic brain injury (TBI), contributing to an increased mortality and a worse neurologic outcome."1.33Quantitation of ischemic events after severe traumatic brain injury in humans: a simple scoring system. ( Bullock, RM; Choi, S; Gilman, C; Kunene, NK; Mazzeo, AT, 2006)
"Brain alkalosis was associated with increased brain lactate/creatine (p < 0."1.31Brain alkaline intracellular pH after neonatal encephalopathy. ( Cowan, FM; Cox, IJ; Edwards, AD; Robertson, NJ, 2002)
"Global cerebral ischemia and increased anaerobic metabolism were considered according to AVDO2 and AVDL respectively."1.30Cerebral hemodynamic changes during sustained hypocapnia in severe head injury: can hyperventilation cause cerebral ischemia? ( Ausina, A; Báguena, M; Ferrer, A; Garnacho, A; Manrique, S; Nadal, M; Sahuquillo, J, 1998)
"However, false cerebral ischemia may be frequently found, if assessed by the lactate-oxygen index, because the denominator of the index (the arteriojugular oxygen content difference) frequently decreases as a function of decreasing hemoglobin, thus yielding false calculated ischemic high values for lactate-oxygen index despite normal cerebral oxygenation and lactate production."1.29Cerebral lactate-oxygen index in acute brain injury with acute anemia: assessment of false versus true ischemia. ( Cruz, J; Hoffstad, OJ; Jaggi, JL, 1994)
"Hyperglycemia was found consistently within 12 hours after injury (224 +/- 98 mg/dl, P less than 0."1.27Hyperglycemia, cerebrospinal fluid lactic acidosis, and cerebral blood flow in severely head-injured patients. ( De Salles, AA; Muizelaar, JP; Young, HF, 1987)

Research

Studies (269)

TimeframeStudies, this research(%)All Research%
pre-199013 (4.83)18.7374
1990's40 (14.87)18.2507
2000's120 (44.61)29.6817
2010's85 (31.60)24.3611
2020's11 (4.09)2.80

Authors

AuthorsStudies
Rajagopalan, S1
Baker, W1
Mahanna-Gabrielli, E1
Kofke, AW1
Balu, R1
Chaudhari, P1
Madaan, A1
Rivera, JC1
Charfi, I1
Habelrih, T1
Hou, X1
Nezhady, M1
Lodygensky, G1
Pineyro, G1
Muanza, T1
Chemtob, S1
Giannì, G1
Minini, A1
Fratino, S1
Peluso, L1
Annoni, F1
Oddo, M7
Schuind, S1
Creteur, J1
Taccone, FS2
Bogossian, EG1
Lei, X1
Qin, D1
Zhu, G1
Wang, S2
Liu, Y3
Liu, H2
Wang, P2
Wang, W2
Cascant-Vilaplana, MM1
Lara-Cantón, I1
Núñez-Ramiro, A1
Solaz-García, Á1
Llorens-Salvador, R1
Quintás, G1
Kuligowski, J1
Vento, M1
Gouvêa Bogossian, E1
Taleb, C1
Aspide, R1
Badenes, R1
Battaglini, D1
Bilotta, F1
Blandino Ortiz, A1
Caricato, A1
Castioni, CA1
Citerio, G1
Ferraro, G1
Martino, C1
Melchionda, I1
Montanaro, F1
Monleon Lopez, B1
Nato, CG1
Piagnerelli, M1
Picetti, E2
Robba, C1
Simonet, O1
Thooft, A1
Arulnathan, E1
Manchanda, A1
Dixit, R1
Kumar, A1
Casey, S1
Goasdoue, K1
Miller, SM1
Brennan, GP1
Cowin, G1
O'Mahony, AG1
Burke, C1
Hallberg, B1
Boylan, GB1
Sullivan, AM1
Henshall, DC1
O'Keeffe, GW1
Mooney, C1
Bjorkman, T1
Murray, DM1
Tassinari, ID1
Andrade, MKG1
da Rosa, LA1
Hoff, MLM1
Nunes, RR1
Vogt, EL1
Fabres, RB1
Sanches, EF1
Netto, CA1
Paz, AH1
de Fraga, LS1
Mölström, S1
Nielsen, TH3
Nordström, CH12
Forsse, A2
Möller, S1
Venö, S1
Mamaev, D1
Tencer, T1
Schmidt, H1
Toft, P1
Kong, VY1
Weale, RD1
Laing, GL1
Bruce, JL1
Oosthuizen, GV1
Sartorius, B1
Brysiewicz, P1
Clarke, DL1
Clausen, AH1
Poulsen, FR1
Chae, MK1
Lee, SE1
Kang, SY1
Sim, MS1
Singh, V1
Zhou, T1
Kalanuria, A1
Andelius, TCK1
Pedersen, MV1
Bøgh, N1
Omann, C1
Hjortdal, VE1
Pedersen, M1
Kyng, KJ1
Henriksen, TB1
Sanchez, JJ1
Bidot, CJ1
O'Phelan, K5
Gajavelli, S2
Yokobori, S4
Olvey, S1
Jagid, J1
Garcia, JA1
Nemeth, Z1
Bullock, R14
Asgari, S1
Vespa, P6
Hu, X1
Bai, W1
Wang, X3
Yuan, W1
Wang, H1
Wang, Z1
Ernst, T1
Park, D1
Stenger, A1
Denny, K1
Green, D1
Chang, C1
Chang, L1
Sala, N1
Suys, T3
Zerlauth, JB1
Bouzat, P3
Messerer, M1
Bloch, J2
Levivier, M1
Magistretti, PJ3
Meuli, R1
Jalloh, I3
Helmy, A3
Shannon, RJ2
Gallagher, CN5
Menon, DK9
Carpenter, KL7
Hutchinson, PJ14
Mazzeo, AT2
Bullock, MR7
Nielsen, T1
Nielsen, H1
Sajja, VS1
Perrine, SA1
Ghoddoussi, F1
Hall, CS1
Galloway, MP1
VandeVord, PJ1
Liang, MY1
Tang, ZX1
Chen, GX1
Rong, J1
Yao, JP1
Chen, Z1
Wu, ZK1
Lama, S1
Auer, RN1
Tyson, R1
Tomanek, B1
Sutherland, GR2
de Lima Oliveira, M2
Paiva, W1
Teixeira, MJ3
Bor-Seng-Shu, E2
Lazaridis, C1
Andrews, CM1
Sahuquillo, J5
Merino, MA2
Sánchez-Guerrero, A1
Arikan, F1
Vidal-Jorge, M1
Martínez-Valverde, T1
Rey, A1
Riveiro, M2
Poca, MA4
Aridas, JD1
Yawno, T1
Sutherland, AE1
Nitsos, I1
Ditchfield, M1
Wong, FY1
Fahey, MC1
Malhotra, A1
Wallace, EM1
Jenkin, G1
Miller, SL1
Hertle, DN3
Santos, E3
Hagenston, AM1
Jungk, C1
Haux, D2
Unterberg, AW7
Sakowitz, OW6
Dienel, GA1
Glenn, TC6
Martin, NA6
McArthur, DL6
Hovda, DA12
Johnson, ML1
Horning, MA2
Brooks, GA2
Grice, P2
Howe, DJ2
Mason, A2
Murphy, MP1
Carpenter, TA1
Pickard, JD10
Chang, CZ1
Wu, SC1
Lin, CL1
Kwan, AL1
Patet, C2
Quintard, H1
Daniel, RT1
Pellerin, L1
Dong, T1
Zhang, Q2
Hamblin, MR1
Wu, MX1
Ruozi, B1
Belletti, D1
Sharma, HS1
Sharma, A1
Muresanu, DF1
Mössler, H1
Forni, F1
Vandelli, MA1
Tosi, G1
Tian, R1
Han, L1
Hou, Z1
Hao, S1
Mao, X1
Zhu, Z1
Tao, X1
Liu, B1
Welling, LC1
Welling, MS1
Figueiredo, EG1
Sun, D2
Xue, A1
Zhang, B1
Lou, H1
Shi, H1
Zhang, X1
Cruz, LJ1
Stammes, MA1
Que, I1
van Beek, ER1
Knol-Blankevoort, VT1
Snoeks, TJA1
Chan, A1
Kaijzel, EL1
Löwik, CWGM1
Tubi, M1
Claassen, J2
Buitrago-Blanco, M1
McArthur, D3
Velazquez, AG1
Tu, B1
Prins, M1
Nuwer, M1
Carteron, L1
Xu, L1
Li, B1
Yang, C1
Li, C1
Peng, Y1
Zhu, XY1
Ma, PS1
Wu, W1
Zhou, R1
Hao, YJ1
Niu, Y1
Sun, T1
Li, YX1
Yu, JQ1
Shen, J1
Huber, M1
Zhao, EY1
Peng, C1
Li, F1
Li, X1
Geng, X1
Ding, Y1
Rogers, ML1
Leong, CL1
Gowers, SA1
Samper, IC1
Jewell, SL1
Khan, A1
McCarthy, L1
Pahl, C2
Tolias, CM2
Walsh, DC1
Strong, AJ3
Boutelle, MG3
Ghosh, A3
Highton, D2
Kolyva, C2
Tachtsidis, I4
Elwell, CE3
Smith, M6
Brody, DL1
Magnoni, S1
Schwetye, KE1
Spinner, ML1
Esparza, TJ1
Stocchetti, N4
Zipfel, GJ1
Holtzman, DM1
Tisdall, MM2
Leung, TS2
Marcoux, J1
McArthur, DA1
Miller, C2
Villablanca, P1
Alger, JR1
Vespa, PM5
Timaru-Kast, R2
Meissner, A2
Heimann, A4
Hoelper, B3
Kempski, O4
Alessandri, B10
Hillered, L4
Enblad, P5
Hartley, CE1
Varma, M1
Fischer, JP1
Riccardi, R1
Strauss, JA1
Shah, S1
Zhang, S1
Yang, ZJ1
Schmidt, JM1
Carrera, E1
Badjatia, N2
Connolly, ES1
Presciutti, M1
Ostapkovich, ND1
Levine, JM1
Le Roux, P2
Mayer, SA2
Zehtabchi, S2
Liu, T1
O'Connell, MT6
Seal, A1
Nortje, J6
Timofeev, I7
Al-Rawi, PG7
Coles, JP3
Fryer, TD2
Garg, SK1
Kipnis, J1
Banerjee, R1
Dahyot-Fizelier, C1
Keong, N1
Czosnyka, M4
Kirkpatrick, PJ6
Gupta, AK7
Koizumi, H1
Fujisawa, H1
Nomura, S1
Kato, S1
Kajiwara, K1
Fujii, M1
Suzuki, M1
Scafidi, S1
O'Brien, J1
Hopkins, I1
Robertson, C1
Fiskum, G2
McKenna, M1
Lima, FD1
Oliveira, MS1
Furian, AF1
Souza, MA1
Rambo, LM1
Ribeiro, LR1
Silva, LF1
Retamoso, LT1
Hoffmann, MS1
Magni, DV1
Pereira, L1
Fighera, MR1
Mello, CF1
Royes, LF1
Afinowi, R1
Tisdall, M1
Keir, G1
Kitchen, N2
Petzold, A2
Manesh, KM1
Halámek, J1
Pita, M1
Zhou, J1
Tam, TK1
Santhosh, P1
Chuang, MC1
Windmiller, JR1
Abidin, D1
Katz, E1
Wang, J1
Fukushima, M2
Lee, SM3
Moro, N1
Sutton, RL4
Nucci-da-Silva, MP1
Amaro, E1
Lescot, T1
Fulla-Oller, L2
Po, C1
Chen, XR1
Puybasset, L1
Gillet, B1
Plotkine, M1
Meric, P1
Marchand-Leroux, C1
Adamides, AA2
Rosenfeldt, FL1
Winter, CD1
Pratt, NM1
Tippett, NJ1
Lewis, PM1
Bailey, MJ1
Cooper, DJ1
Rosenfeld, JV2
Yatsushige, H1
Takasato, Y1
Masaoka, H1
Hayakawa, T1
Otani, N1
Yoshino, Y1
Sumiyoshi, K1
Sugawara, T1
Miyawaki, H1
Aoyagi, C1
Takeuchi, S1
Suzuki, G1
Meierhans, R3
Béchir, M3
Ludwig, S1
Sommerfeld, J3
Brandi, G3
Haberthür, C1
Stocker, R4
Stover, JF5
Feuerstein, D1
Manning, A1
Hashemi, P2
Bhatia, R1
Fabricius, M2
Tolias, C1
Ervine, M1
Lakshmanan, R1
Loo, JA1
Drake, T1
Leblanc, J1
Ytterberg, AJ1
Etchepare, M3
Dar, DE1
Soustiel, JF3
Zaaroor, M3
Brotfain, EM1
Leibowitz, A1
Shapira, Y1
Semenikhina, L1
Solopov, A1
Krausz, MM1
Fasshauer, M2
Cottini, SR1
Borrull, A1
Expósito, L1
Hellewell, SC1
Yan, EB1
Agyapomaa, DA1
Bye, N2
Morganti-Kossmann, MC3
Zhao, QJ1
Zhang, XG1
Wang, LX1
Salci, K3
Goiny, M2
Contant, CF4
Piper, I3
Nilsson, P3
GURDJIAN, EE1
STONE, WE1
Clausen, F1
Gustafsson, J1
Krajewski, KL1
Orakcioglu, B1
Kiening, KL4
De Fazio, M1
Rammo, R1
Smielewski, P2
Larach, DB1
Kofke, WA1
Pritchard, C1
Watanabe, A2
Matsumoto, G2
Onda, H2
Masuno, T2
Fuse, A2
Kushimoto, S2
Yokota, H2
Zweckberger, K2
Simunovic, F1
Karathanou, A1
Paterakis, K1
Pakopoulou, M1
Tasiou, A1
Hadjigeorgiou, G1
Chovas, A1
Paraforos, G1
Fountas, K1
Komnos, A1
Schüpbach, R1
Hackenberg, K1
Jung, CS1
Omerhodzić, I1
Dizdarević, K1
Rotim, K1
Hajdarpasić, E1
Niksić, M1
Bejtić-Custović, E1
Selimović, E1
Custović, M1
Tanguy, M1
Seguin, P1
Laviolle, B1
Bleichner, JP1
Morandi, X1
Malledant, Y1
Purins, K1
Wiklund, L1
Lewén, A2
Stein, NR1
Sánchez-Porras, R1
Zheng, Z1
Blanié, A1
Vigué, B2
Benhamou, D2
Duranteau, J2
Geeraerts, T2
Elwell, C1
Schwandt, E1
Kamada, Y1
Nagata, M1
Helbok, R1
Kurtz, P1
Schmidt, MJ1
Stuart, MR1
Fernandez, L1
Connolly, SE1
Lee, K1
Schmutzhard, E1
James, ML1
Olson, DM1
Graffagnino, C1
Neligan, PJ1
Baranov, D2
Peerdeman, SM1
Girbes, AR1
Vandertop, WP1
Macmillan, CS1
Wild, JM1
Wardlaw, JM1
Andrews, PJ1
Marshall, I1
Easton, VJ1
Robertson, NJ1
Cowan, FM1
Cox, IJ1
Edwards, AD1
Lourido, J1
Ederoth, P1
Sundvall, N1
Ungerstedt, U6
Marion, DW5
Puccio, A2
Wisniewski, SR1
Kochanek, P1
Dixon, CE1
Bullian, L1
Carlier, P1
Zornow, MH1
Prough, DS1
Chen, ZG1
Lu, YC1
Zhu, C1
Zhang, GJ1
Ding, XH1
Jiang, JY1
Reinstrup, P3
Xu, W1
Gärdenfors, A1
Brenner, T1
Freier, MC1
Holshouser, BA2
Burley, T1
Ashwal, S2
Tyrak, J1
Gościński, I1
Moskała, M1
Traczewski, W1
Witkowska, R1
Andres, J1
Glenn, T2
Kelly, D1
Bergsneider, M3
Beyer, TF1
Dohse, NK1
Kroppenstedt, SN1
Thomale, UW1
Schaser, KD1
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Robertson, CS6
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Schaller, B2
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Greiner, C1
Van Aken, H1
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Hirschberg, R1
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Wu, HM1
Huang, SC1
Folbergrová, J1
Druga, R1
Otáhal, J1
Haugvicová, R1
Mares, P1
Kubová, H1
Engström, M2
Polito, A1
Romner, B2
Ryding, E1
Makoroff, KL1
Cecil, KM2
Care, M1
Ball, WS1
Stuckey, DJ1
Anthony, DC1
Lowe, JP1
Miller, J1
Palm, WM1
Styles, P1
Perry, VH1
Blamire, AM1
Sibson, NR1
McBeth, BD1
Stern, SA2
Mertz, M2
Zink, BJ2
Alves, OL2
Clausen, T4
Reeves, TM1
Liang, YM1
Liu, YS1
Qu, HT1
Wang, GW1
Li, CH1
Shik, V2
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Mahamid, E2
Prins, ML1
Fujima, LS1
Bartnik, BL2
Harris, NG1
Khaldi, A3
Zauner, A8
Doppenberg, E6
Menzel, M2
Soukup, J2
Hillman, J1
Milos, P1
Yu, ZQ1
Sjögren, F1
Anderson, C1
Mellergård, P2
Howells, T1
Ronne-Engström, E1
Zhi, DS1
Huang, HL1
Zhang, GB1
Li, AL1
Fan, WJ1
Wang, C1
Mo, LD1
Chistyakov, A1
Benenson, R1
Kunene, NK1
Choi, S5
Bullock, RM1
Schott, U1
Contant, C1
Phillips, DJ1
Nguyen, P1
Kossmann, T2
Vallance, S1
Murray, L1
Levasseur, JE3
Zhou, Z2
Altememi, N1
Eliseo, M1
Hirt, D1
Rusakov, VV1
Dolgikh, VT1
Samuelson, R1
Mazzeo, A1
Kunene, N1
Young, HF6
Neligan, P1
Murányi, M1
Lacza, Z1
Vilalta, A1
Garnacho, A3
Sinert, R1
Soghoian, S1
Carmody, K1
Shah, L1
Kumar, M1
Lucchesi, M1
Manville, J1
Laurer, HL1
Steudel, WI2
Mautes, AE2
Chio, CC1
Kuo, JR1
Hsiao, SH1
Chang, CP1
Lin, MT1
Huang, JH1
Su, ZK1
Wang, SM1
Wong, DY1
Hollister, SJ1
Krebsbach, PH1
Nosrat, C1
Holloway, R1
Harvey, HB1
Rice, AC3
Hamm, RJ2
Andres, RH1
Fuhrer, M1
Müller, A1
Widmer, H1
Chieregato, A1
Marchi, M1
Fainardi, E1
Targa, L1
Friggeri, A1
Mazoit, JX1
Aigbirhio, FI2
Outtrim, JG1
Chatfield, DA2
Belli, A1
Sen, J1
Russo, S1
Casey, PA1
McKenna, MC1
Saraswati, M1
Robertson, CL1
Brandt, L1
Filos, K1
Link, J1
Tramontano, R1
Cordero, D1
Bagnari, A1
Pagani, L1
Langemann, H2
Mendelowitsch, A2
Gratzl, O2
Prasad, MR1
Ramaiah, C1
McIntosh, TK3
Dempsey, RJ1
Hipkens, S1
Yurek, D1
Cruz, J2
Hoffstad, OJ2
Jaggi, JL1
Yuan, XQ1
Wade, CE1
Robles, A1
Coello, F1
Godet, C1
Triginer, C1
Rubio, E1
Meller, D1
Bellander, BM1
Schmidt-Kastner, R1
Ingvar, M1
Zager, EL1
Sinson, GP1
Luh, GY1
Shu, S1
Kahlon, S1
Auld, KL1
Tomasi, LG1
Perkin, RM1
Hinshaw, DB1
Prasad, RM2
Laabich, A1
Zhang, L1
Maki, A1
Clerici, WJ1
Hicks, R1
Butcher, J1
Barron, S1
Gopinath, SP3
Uzura, M2
Smith, DH1
Meaney, DF1
Chen, XH1
Gennarelli, TA1
Lenkinski, RE1
Dose, JM1
Ausina, A1
Báguena, M1
Nadal, M1
Manrique, S1
Ferrer, A1
Nakamura, T1
Nagao, S1
Kawai, N1
Honma, Y1
Kuyama, H1
Holzschuh, M2
Metz, C3
Woertgen, C1
Rothörl, RD1
Brawanski, A1
Bein, T1
Kallenbach, B1
Taeger, K1
Yamamura, H1
Hiraide, A1
Matsuoka, T1
Takaoka, M1
Shimazu, T1
Sugimoto, H1
Krishnappa, IK1
Pleines, UE1
Castillo, L1
Velasco, N1
Wainstein, C1
Bugedo, G1
Hernández, G1
Klaassen, J1
Errandonea, M1
Méndez, J1
Acosta, AM1
Glass, TF2
Fabian, MJ2
Schweitzer, JB2
Weinberg, JA2
Proctor, KG2
Rossi, S1
Woodward, J2
Koura, S1
Doppenberg, EM2
Massie, TS1
Letarte, PB1
Brown, SD1
Shiogai, T1
Nara, I1
Saruta, K1
Hara, M1
Saito, I1
Maskell, LB3
Aquilani, R1
Viglio, S1
Iadarola, P1
Guarnaschelli, C1
Arrigoni, N1
Fugazza, G1
Catapano, M1
Boschi, F1
Dossena, M1
Pastoris, O1
Chen, T2
Qian, YZ1
Rice, A1
Zhu, JP1
Di, X1
Bentzer, P1
Davidsson, H1
Grände, PO2
Fandino, J1
Prokop, S1
Trentz, O1
Imhof, HG1
Kett-White, R2
Richards, HK1
Hutchinson, DB2
Möller, AD1
Rockswold, SB1
Rockswold, GL1
Vargo, JM1
Erickson, CA1
Bergman, TA1
Biros, MH1
Bell, MJ1
Carcillo, JA1
Clark, RS1
Mi, Z1
Jackson, EK1
Williams, PJ1
Lane, JR1
Turkel, CC1
Capparelli, EV1
Dziewanowska, Z1
Fox, AW1
Ustün, ME1
Gürbilek, M1
Ak, A1
Vatansev, H1
Duman, A1
Thome, D1
Nacimiento, AC1
Yang, Y1
Shohami, E1
Ritz, MF1
Ros, J2
Schultz, CH1
Johnston, P1
Keep, RF1
Eriskat, J1
Stoffel, M1
Plesnila, N1
Rinecker, M1
Baethmann, A1
Ståhl, N2
Hallström, A1
Pecinska, N1
Fillenz, M1
Leegsma-Vogt, G1
Venema, K1
Postema, F1
Korf, J1
Meixensberger, J1
Kunze, E1
Barcsay, E1
Vaeth, A1
Roosen, K1
Zsoldos, R1
Wilson, MS1
Fryer, TF1
Minhas, PS1
Clark, JC1
Jensen, K2
Ohrstrøm, J1
Cold, GE2
Astrup, J2
Sunderland, PM1
Heilbrun, MP1
Shackford, SR1
Zhuang, J1
Schmoker, J1
Corbett, RJ1
Laptook, AR1
Ruley, JI1
Garcia, D1
Caron, MJ1
Becker, DP1
Kuznetsova, VM1
Borshchagovskiĭ, ML1
Raĭkhinshteĭn, VE1
Krauze, VE1
Ohrström, J1
Bakay, RA1
Sweeney, KM1
Wood, JH1
Odinak, MM1
Zaporoshchenko, IA1
Frewen, TC1
Sumabat, WO1
Han, VK1
Campbell, K1
Tiffin, N1
Inao, S1
Marmarou, A1
Clarke, GD1
Andersen, BJ1
Fatouros, PP1
Dauberschmidt, R2
Förster, I2
Griess, B1
Mrochen, H1
Schreiber, G1
Klages, G2
Kynast, J2
Dressler, C2
Schönbeck, S1
Lun, A1
Grossman, RG1
Narayan, RK1
De Salles, AA1
Muizelaar, JP1
Faden, AI1
Bendall, MR1
Bender, V1
Meyer, M1
Arnold, K1

Clinical Trials (11)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Exogenous Sodium Lactate Infusion in Traumatic Brain Injury (ELI-TBI)[NCT02776488]Phase 20 participants (Actual)Interventional2020-09-30Withdrawn (stopped due to The manufacturer of sodium lactate has stopped making the medication)
Uncovering the 'ORIGINS' of Diabetes[NCT02226640]80 participants (Actual)Observational2010-11-30Completed
Continuous, Non-invasive Monitoring of Intraoperative Cerebral Perfusion and Oxidative Metabolism (CPOM): a Knowledge Translation Study.[NCT03907904]40 participants (Anticipated)Observational2019-07-01Recruiting
Spreading Depolarization and Ketamine Suppression[NCT02501941]Phase 110 participants (Actual)Interventional2015-07-31Completed
Assessment of the Clinical Importance of Insulin Resistance & Steroid-Associated Hyperglycemia in Relapsing Multiple Sclerosis[NCT03004079]160 participants (Anticipated)Observational2016-10-31Recruiting
Multimodality Monitoring Directed Management of Patients Suffering From Traumatic Brain Injury[NCT02993549]100 participants (Anticipated)Observational2017-09-16Recruiting
Continuous Monitoring of Cerebral Metabolic State. Combined Intracerebral and Jugular Bulb Microdialysis in Neurocritical Care.[NCT03314779]12 participants (Actual)Observational2017-08-28Completed
Conservative vs Conventional Oxygen Administration in Critically Ill Patients: Effects on ICU Mortality. A Multicentre Randomized Open Label Clinical Trial[NCT04198077]Phase 41,000 participants (Anticipated)Interventional2019-12-04Recruiting
Impact of Intermediate Normal Compared to High Normal Oxygen Levels on Outcomes of Patients Presenting in the Emergency Department With Severe Traumatic Brain Injury (INACHOS): a Pilot Randomized Controlled Trial[NCT05464277]50 participants (Anticipated)Interventional2022-08-31Not yet recruiting
Cerebral Blood Flow (CBF) Disturbances Following Traumatic Brain Injury (TBI) and Subarachnoid Hemorrhage (SAH)[NCT00807833]20 participants (Actual)Observational2009-02-28Completed
Safety and Efficacy of Therapeutic Hypothermia in Acute Ischemic Stroke Patients Treated With Mechanical Thrombectomy: a Prospective, Randomized, Controlled Clinical Study[NCT05779176]252 participants (Anticipated)Interventional2023-05-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

18 reviews available for lactic acid and Acute Brain Injuries

ArticleYear
The Impact of Short-Term Hyperoxia on Cerebral Metabolism: A Systematic Review and Meta-Analysis.
    Neurocritical care, 2022, Volume: 37, Issue:2

    Topics: Brain Injuries; Glucose; Humans; Hyperoxia; Lactic Acid; Microdialysis; Observational Studies as Top

2022
Temporal Evolution of Signal Alterations in the Deep Gray Nuclei in term Neonates With Hypoxic-Ischemic Brain Injury: A Comprehensive Review.
    Journal of child neurology, 2023, Volume: 38, Issue:8-9

    Topics: Brain; Brain Injuries; Diffusion Magnetic Resonance Imaging; Humans; Hypoxia-Ischemia, Brain; Infant

2023
[Cerebral monitoring of neurocritical patients].
    Ugeskrift for laeger, 2018, Jul-23, Volume: 180, Issue:30

    Topics: Brain; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Humans; Intracranial Pressure; L

2018
Cerebral Microdialysis in Neurocritical Care.
    Current neurology and neuroscience reports, 2018, 10-23, Volume: 18, Issue:12

    Topics: Biomarkers; Brain Injuries; Brain Injuries, Traumatic; Glucose; Humans; Lactic Acid; Microdialysis;

2018
Mitochondrial neuroprotection in traumatic brain injury: rationale and therapeutic strategies.
    CNS & neurological disorders drug targets, 2014, Volume: 13, Issue:4

    Topics: Animals; Brain Injuries; Cyclosporine; Humans; Lactic Acid; Mitochondria; Neuroprotective Agents; Ra

2014
Lactate and the injured brain: friend or foe?
    Current opinion in critical care, 2014, Volume: 20, Issue:2

    Topics: Brain Injuries; Cerebral Cortex; Cerebrovascular Circulation; Energy Metabolism; Female; Glycolysis;

2014
Brain tissue oxygenation, lactate-pyruvate ratio, and cerebrovascular pressure reactivity monitoring in severe traumatic brain injury: systematic review and viewpoint.
    Neurocritical care, 2014, Volume: 21, Issue:2

    Topics: Arterial Pressure; Brain Injuries; Cerebrovascular Circulation; Humans; Lactic Acid; Monitoring, Phy

2014
Lactate shuttling and lactate use as fuel after traumatic brain injury: metabolic considerations.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:11

    Topics: Animals; Brain Injuries; Brain Ischemia; Glutamic Acid; Humans; Lactic Acid; Mitochondria; Oxidation

2014
Cerebral Lactate Metabolism After Traumatic Brain Injury.
    Current neurology and neuroscience reports, 2016, Volume: 16, Issue:4

    Topics: Animals; Brain Injuries; Cerebrovascular Circulation; Glucose; Humans; Hypoxia; Lactic Acid; Neuropr

2016
A systematic review of Magnetic Resonance Imaging and Spectroscopy in brain injury after drowning.
    Brain injury, 2009, Volume: 23, Issue:9

    Topics: Aspartic Acid; Brain Injuries; Child; Child, Preschool; Drowning; Female; Humans; Hypoxia, Brain; In

2009
Trauma and aggressive homeostasis management.
    Anesthesiology clinics, 2013, Volume: 31, Issue:1

    Topics: Acidosis, Lactic; Brain Injuries; Homeostasis; Humans; Hyperglycemia; Hypothermia, Induced; Insulin;

2013
Secondary mechanisms in traumatic brain injury: a nurse's perspective.
    The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses, 1999, Volume: 31, Issue:2

    Topics: Brain Injuries; Excitatory Amino Acids; Free Radicals; Humans; Ion Channels; Lactic Acid; Lipid Pero

1999
Hyperoxia in head injury: therapeutic tool?
    Current opinion in critical care, 2004, Volume: 10, Issue:2

    Topics: Animals; Brain; Brain Injuries; Humans; Hyperbaric Oxygenation; Italy; Lactic Acid; Oxygen

2004
Trauma and aggressive homeostasis management.
    Anesthesiology clinics, 2007, Volume: 25, Issue:1

    Topics: Acidosis; Animals; Brain Injuries; Homeostasis; Humans; Hyperglycemia; Hypothermia; Lactic Acid; Sho

2007
[Astrocytes in health and disease].
    Orvosi hetilap, 2007, Apr-15, Volume: 148, Issue:15

    Topics: Animals; Astrocytes; Blood-Brain Barrier; Brain Injuries; Calcium; Cerebrospinal Fluid; Cerebrovascu

2007
[Lactate as an indicator of ischemic-traumatic brain injury].
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 1999, Volume: 34, Issue:4

    Topics: Animals; Biomarkers; Brain Injuries; Brain Ischemia; Humans; Lactic Acid

1999
Changes in the treatment of head injury.
    Neurosurgery clinics of North America, 1991, Volume: 2, Issue:2

    Topics: Amino Acids; Animals; Brain Damage, Chronic; Brain Injuries; Critical Care; Free Radicals; Humans; I

1991
Pathophysiology of cerebrospinal fluid in head injury: Part 1. Pathological changes in cerebrospinal fluid solute composition after traumatic injury.
    Neurosurgery, 1986, Volume: 18, Issue:2

    Topics: Acetylcholine; Brain Edema; Brain Injuries; Calcium; Cerebrospinal Fluid Proteins; Dopamine; Fatty A

1986

Trials

26 trials available for lactic acid and Acute Brain Injuries

ArticleYear
Bedside microdialysis for detection of early brain injury after out-of-hospital cardiac arrest.
    Scientific reports, 2021, 08-05, Volume: 11, Issue:1

    Topics: Adult; Aged; Biomarkers; Brain; Brain Injuries; Brain Ischemia; Cerebral Veins; Energy Metabolism; F

2021
Increase in cerebral aerobic metabolism by normobaric hyperoxia after traumatic brain injury.
    Journal of neurosurgery, 2008, Volume: 109, Issue:3

    Topics: Adult; Brain Injuries; Female; Humans; Hyperoxia; Lactic Acid; Male; Microdialysis; Middle Aged; Oxi

2008
Ventriculostomy for control of raised ICP in acute traumatic brain injury.
    Acta neurochirurgica. Supplement, 2008, Volume: 102

    Topics: Adult; Blood Pressure; Brain Injuries; Cerebrospinal Fluid; Female; Glasgow Coma Scale; Humans; Intr

2008
Mild hypothermia therapy reduces blood glucose and lactate and improves neurologic outcomes in patients with severe traumatic brain injury.
    Journal of critical care, 2011, Volume: 26, Issue:3

    Topics: Adult; Blood Glucose; Brain Injuries; Female; Follow-Up Studies; Glasgow Outcome Scale; Humans; Hypo

2011
Biochemical markers analyzed using microdialysis and traumatic brain injury outcomes.
    Journal of neurosurgical sciences, 2011, Volume: 55, Issue:3

    Topics: Adult; Biomarkers; Brain Injuries; Critical Care; Female; Follow-Up Studies; Humans; Lactic Acid; Ma

2011
Cerebral microdialysis: perioperative monitoring and treatment of severe neurosurgical patient.
    Acta clinica Croatica, 2011, Volume: 50, Issue:1

    Topics: Brain Injuries; Glucose; Glycerol; Humans; Intracranial Hemorrhage, Traumatic; Lactic Acid; Microdia

2011
Cerebral microdialysis effects of propofol versus midazolam in severe traumatic brain injury.
    Journal of neurotrauma, 2012, Apr-10, Volume: 29, Issue:6

    Topics: Adult; Biomarkers; Brain Chemistry; Brain Injuries; Cerebral Cortex; Female; Glucose; Glutamic Acid;

2012
A microdialysis study of oral vigabatrin administration in head injury patients: preliminary evaluation of multimodality monitoring.
    Acta neurochirurgica. Supplement, 2012, Volume: 114

    Topics: Administration, Oral; Adolescent; Adult; Aged; Amino Acids; Anticonvulsants; Blood Pressure; Brain C

2012
A pilot study of cerebral and haemodynamic physiological changes during sedation with dexmedetomidine or propofol in patients with acute brain injury.
    Anaesthesia and intensive care, 2012, Volume: 40, Issue:6

    Topics: Body Temperature; Brain Injuries; Consciousness Monitors; Cross-Over Studies; Dexmedetomidine; Glasg

2012
Extracellular brain pH with or without hypoxia is a marker of profound metabolic derangement and increased mortality after traumatic brain injury.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2013, Volume: 33, Issue:3

    Topics: Adult; Biomarkers; Brain; Brain Injuries; Disease-Free Survival; Female; Glucose; Humans; Hydrogen-I

2013
Effect of hyperventilation on extracellular concentrations of glutamate, lactate, pyruvate, and local cerebral blood flow in patients with severe traumatic brain injury.
    Critical care medicine, 2002, Volume: 30, Issue:12

    Topics: Adult; Brain; Brain Injuries; Brain Ischemia; Female; Glutamic Acid; Humans; Hyperventilation; Lacti

2002
Assessment of the lower limit for cerebral perfusion pressure in severe head injuries by bedside monitoring of regional energy metabolism.
    Anesthesiology, 2003, Volume: 98, Issue:4

    Topics: Adolescent; Adult; Aged; Blood Gas Analysis; Brain Chemistry; Brain Injuries; Cerebrovascular Circul

2003
[Experiments in evaluation of brain oxygenation and metabolism based on continuous bilateral SjO2 monitoring and metabolic glucose transformations in patients after severe cranio-cerebral injuries].
    Folia medica Cracoviensia, 2001, Volume: 42, Issue:4

    Topics: Adult; Aged; Blood Glucose; Brain; Brain Injuries; Female; Glasgow Coma Scale; Humans; Jugular Veins

2001
Relationships between cerebrospinal fluid markers of excitotoxicity, ischemia, and oxidative damage after severe TBI: the impact of gender, age, and hypothermia.
    Journal of neurotrauma, 2004, Volume: 21, Issue:2

    Topics: Adult; Age Factors; Biomarkers; Brain Injuries; Brain Ischemia; F2-Isoprostanes; Female; Glutamic Ac

2004
Dynamic changes in brain glucose and lactate in pericontusional areas of the human cerebral cortex, monitored with rapid sampling on-line microdialysis: relationship with depolarisation-like events.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2005, Volume: 25, Issue:3

    Topics: Adult; Aged; Brain; Brain Edema; Brain Injuries; Cerebral Cortex; Cortical Spreading Depression; Ele

2005
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2005, Volume: 25, Issue:6

    Topics: Acute Disease; Adolescent; Adult; Brain Injuries; Brain Ischemia; Glucose; Humans; Incidence; Lactic

2005
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2005, Volume: 25, Issue:6

    Topics: Acute Disease; Adolescent; Adult; Brain Injuries; Brain Ischemia; Glucose; Humans; Incidence; Lactic

2005
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2005, Volume: 25, Issue:6

    Topics: Acute Disease; Adolescent; Adult; Brain Injuries; Brain Ischemia; Glucose; Humans; Incidence; Lactic

2005
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2005, Volume: 25, Issue:6

    Topics: Acute Disease; Adolescent; Adult; Brain Injuries; Brain Ischemia; Glucose; Humans; Incidence; Lactic

2005
Intracerebral microdialysis and intracranial compliance monitoring of patients with traumatic brain injury.
    Journal of clinical monitoring and computing, 2006, Volume: 20, Issue:1

    Topics: Adult; Brain Injuries; Coma; Compliance; Female; Fever; Glasgow Coma Scale; Humans; Lactic Acid; Mal

2006
Comparison of moderate hyperventilation and mannitol for control of intracranial pressure control in patients with severe traumatic brain injury--a study of cerebral blood flow and metabolism.
    Acta neurochirurgica, 2006, Volume: 148, Issue:8

    Topics: Adolescent; Adult; Aged; Brain Edema; Brain Injuries; Brain Ischemia; Cerebral Cortex; Cerebrovascul

2006
Lack of utility of arteriojugular venous differences of lactate as a reliable indicator of increased brain anaerobic metabolism in traumatic brain injury.
    Journal of neurosurgery, 2007, Volume: 106, Issue:4

    Topics: Adolescent; Adult; Aged; Brain; Brain Injuries; Female; Glasgow Outcome Scale; Humans; Jugular Veins

2007
Near-infrared spectroscopy monitoring of brain oxygen in infant cardiac surgery.
    Asian cardiovascular & thoracic annals, 2007, Volume: 15, Issue:3

    Topics: Biomarkers; Brain; Brain Injuries; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Circulatory

2007
Thiopental attenuates energetic impairment but fails to normalize cerebrospinal fluid glutamate in brain-injured patients.
    Critical care medicine, 1999, Volume: 27, Issue:7

    Topics: Adolescent; Adult; Biomarkers; Brain Injuries; Electroencephalography; Female; Glutamic Acid; Humans

1999
Low-dose prostacyclin in treatment of severe brain trauma evaluated with microdialysis and jugular bulb oxygen measurements.
    Acta anaesthesiologica Scandinavica, 2000, Volume: 44, Issue:7

    Topics: Adult; Aged; Biomarkers; Brain Injuries; Energy Metabolism; Epoprostenol; Female; Humans; Hypoxia; J

2000
High level of extracellular potassium and its correlates after severe head injury: relationship to high intracranial pressure.
    Journal of neurosurgery, 2000, Volume: 93, Issue:5

    Topics: Adolescent; Adult; Brain; Brain Chemistry; Brain Injuries; Cerebrovascular Circulation; Extracellula

2000
Effects of hyperbaric oxygenation therapy on cerebral metabolism and intracranial pressure in severely brain injured patients.
    Journal of neurosurgery, 2001, Volume: 94, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Gas Analysis; Blood Pressure; Brain; Brain Injurie

2001
Dichloroacetate: population pharmacokinetics with a pharmacodynamic sequential link model.
    Journal of clinical pharmacology, 2001, Volume: 41, Issue:3

    Topics: Adult; Aged; Bayes Theorem; Brain Injuries; Chromatography, High Pressure Liquid; Computer Simulatio

2001
Clinical cerebral microdialysis: brain metabolism and brain tissue oxygenation after acute brain injury.
    Neurological research, 2001, Volume: 23, Issue:8

    Topics: Adolescent; Adult; Brain; Brain Injuries; Critical Care; Female; Glucose; Glutamic Acid; Humans; Int

2001

Other Studies

225 other studies available for lactic acid and Acute Brain Injuries

ArticleYear
Hierarchical Cluster Analysis Identifies Distinct Physiological States After Acute Brain Injury.
    Neurocritical care, 2022, Volume: 36, Issue:2

    Topics: Brain; Brain Injuries; Cluster Analysis; Hospital Mortality; Humans; Intracranial Pressure; Lactic A

2022
Neuronal GPR81 regulates developmental brain angiogenesis and promotes brain recovery after a hypoxic ischemic insult.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2022, Volume: 42, Issue:7

    Topics: Animals; Animals, Newborn; Brain; Brain Injuries; Female; Hypoxia-Ischemia, Brain; Infarction; Ische

2022
To Investigate the Effect of Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI) in the Diagnosis of Mild Craniocerebral Injury.
    BioMed research international, 2022, Volume: 2022

    Topics: Brain Injuries; Brain Injuries, Traumatic; Choline; Coma; Creatinine; Diffusion Tensor Imaging; Huma

2022
Clinical application of BIS combined with LCR in assessing brain function and prognosis of patients with severe carbon monoxide poisoning.
    Clinical neurology and neurosurgery, 2023, Volume: 224

    Topics: Brain; Brain Injuries; Carbon Monoxide Poisoning; Humans; Lactic Acid; Prognosis; Retrospective Stud

2023
Clinical application of BIS combined with LCR in assessing brain function and prognosis of patients with severe carbon monoxide poisoning.
    Clinical neurology and neurosurgery, 2023, Volume: 224

    Topics: Brain; Brain Injuries; Carbon Monoxide Poisoning; Humans; Lactic Acid; Prognosis; Retrospective Stud

2023
Clinical application of BIS combined with LCR in assessing brain function and prognosis of patients with severe carbon monoxide poisoning.
    Clinical neurology and neurosurgery, 2023, Volume: 224

    Topics: Brain; Brain Injuries; Carbon Monoxide Poisoning; Humans; Lactic Acid; Prognosis; Retrospective Stud

2023
Clinical application of BIS combined with LCR in assessing brain function and prognosis of patients with severe carbon monoxide poisoning.
    Clinical neurology and neurosurgery, 2023, Volume: 224

    Topics: Brain; Brain Injuries; Carbon Monoxide Poisoning; Humans; Lactic Acid; Prognosis; Retrospective Stud

2023
Longitudinal perturbations of plasma nuclear magnetic resonance profiles in neonatal encephalopathy.
    Pediatric research, 2023, Volume: 94, Issue:1

    Topics: 3-Hydroxybutyric Acid; Biomarkers; Brain Injuries; Humans; Hypothermia, Induced; Hypoxia-Ischemia, B

2023
Cerebro-spinal fluid glucose and lactate concentrations changes in response to therapies in patIents with primary brain injury: the START-TRIP study.
    Critical care (London, England), 2023, 03-31, Volume: 27, Issue:1

    Topics: Adult; Brain Injuries; Glucose; Humans; Intracranial Pressure; Lactic Acid; Linear Models; Prospecti

2023
Temporally Altered miRNA Expression in a Piglet Model of Hypoxic Ischemic Brain Injury.
    Molecular neurobiology, 2020, Volume: 57, Issue:10

    Topics: Animals; Animals, Newborn; Biomarkers; Bone Morphogenetic Protein Receptors, Type II; Brain; Brain I

2020
Lactate Administration Reduces Brain Injury and Ameliorates Behavioral Outcomes Following Neonatal Hypoxia-Ischemia.
    Neuroscience, 2020, 11-10, Volume: 448

    Topics: Animals; Animals, Newborn; Brain; Brain Injuries; Disease Models, Animal; Female; Hypoxia; Hypoxia-I

2020
Cerebral microdialysis in TBI-limitations and possibilities.
    Acta neurochirurgica, 2017, Volume: 159, Issue:12

    Topics: Brain Injuries; Humans; Intracranial Pressure; Lactic Acid; Microdialysis

2017
A raised serum lactate level is an independent predictor of in-hospital mortality in patients with isolated cerebral gunshot wounds.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2018, Apr-25, Volume: 108, Issue:5

    Topics: Adult; Brain Injuries; Emergency Service, Hospital; Female; Hospital Mortality; Humans; Lactic Acid;

2018
Monitoring of Cerebral Metabolism in Postcardiac Arrest Patients: A Pilot Study.
    Therapeutic hypothermia and temperature management, 2018, Volume: 8, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Brain Injuries; Cerebrum; Female; Heart Arrest; Humans; Lactic Acid;

2018
Impaired Cerebral Metabolism in Injured Brain: Can Lactate Step in for Glucose?
    Critical care medicine, 2018, Volume: 46, Issue:10

    Topics: Brain; Brain Injuries; Cerebrovascular Circulation; Glucose; Humans; Lactic Acid

2018
Consequence of insertion trauma - effect on early measurements when using intracerebral devices.
    Scientific reports, 2019, 07-23, Volume: 9, Issue:1

    Topics: Animals; Brain; Brain Injuries; Glucose; Glycerol; Lactic Acid; Microdialysis; Prostheses and Implan

2019
Neuromonitoring with microdialysis in severe traumatic brain injury patients.
    Acta neurochirurgica. Supplement, 2013, Volume: 118

    Topics: Adolescent; Adult; Aged; Amino Acids; Biomarkers; Brain; Brain Injuries; Female; Glasgow Outcome Sca

2013
Is there any association between cerebral vasoconstriction/vasodilatation and microdialysis Lactate to Pyruvate ratio increase?
    Neurocritical care, 2013, Volume: 19, Issue:1

    Topics: Adult; Aged; Algorithms; Brain; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Female;

2013
Application of PLGA/type I collagen/chitosan artificial composite dura mater in the treatment of dural injury.
    Journal of materials science. Materials in medicine, 2013, Volume: 24, Issue:9

    Topics: Animals; Brain Injuries; Collagen Type I; Dura Mater; Lactic Acid; Polyglycolic Acid; Polylactic Aci

2013
Impact of methamphetamine on regional metabolism and cerebral blood flow after traumatic brain injury.
    Neurocritical care, 2013, Volume: 19, Issue:2

    Topics: Adolescent; Adult; Amphetamine-Related Disorders; Aspartic Acid; Brain; Brain Injuries; Central Nerv

2013
Cerebral extracellular lactate increase is predominantly nonischemic in patients with severe traumatic brain injury.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2013, Volume: 33, Issue:11

    Topics: Adult; Brain Injuries; Cerebral Cortex; Cerebrovascular Circulation; Cohort Studies; Extracellular S

2013
Lactate uptake by the injured human brain: evidence from an arteriovenous gradient and cerebral microdialysis study.
    Journal of neurotrauma, 2013, Dec-15, Volume: 30, Issue:24

    Topics: Adolescent; Adult; Blood Glucose; Brain; Brain Injuries; Cerebral Arteries; Cerebrovascular Circulat

2013
Lactate uptake against a concentration gradient: misinterpretation of analytical imprecision.
    Journal of neurotrauma, 2014, Sep-01, Volume: 31, Issue:17

    Topics: Brain; Brain Injuries; Cerebral Arteries; Cerebrovascular Circulation; Female; Humans; Jugular Veins

2014
Response to letter "Lactate uptake against a concentration gradient: misinterpretation of analytical imprecision".
    Journal of neurotrauma, 2014, Sep-01, Volume: 31, Issue:17

    Topics: Brain; Brain Injuries; Cerebral Arteries; Cerebrovascular Circulation; Female; Humans; Jugular Veins

2014
Blast neurotrauma impairs working memory and disrupts prefrontal myo-inositol levels in rats.
    Molecular and cellular neurosciences, 2014, Volume: 59

    Topics: Animals; Betaine; Blast Injuries; Brain Injuries; Creatine; Ethanolamines; gamma-Aminobutyric Acid;

2014
Is selective antegrade cerebral perfusion superior to retrograde cerebral perfusion for brain protection during deep hypothermic circulatory arrest? Metabolic evidence from microdialysis.
    Critical care medicine, 2014, Volume: 42, Issue:5

    Topics: Analysis of Variance; Animals; Brain; Brain Injuries; Circulatory Arrest, Deep Hypothermia Induced;

2014
Exogenous lactate supplementation to the injured brain: misleading conclusions with clinical implications.
    Intensive care medicine, 2014, Volume: 40, Issue:6

    Topics: Brain; Brain Injuries; Humans; Lactic Acid

2014
Hypertonic lactate and the injured brain: facts and the potential for positive clinical implications.
    Intensive care medicine, 2014, Volume: 40, Issue:6

    Topics: Brain Injuries; Humans; Hypertonic Solutions; Lactic Acid

2014
Lactate storm marks cerebral metabolism following brain trauma.
    The Journal of biological chemistry, 2014, Jul-18, Volume: 289, Issue:29

    Topics: Acetic Acid; Animals; Astrocytes; Brain; Brain Injuries; Glial Fibrillary Acidic Protein; Glucose; G

2014
Brain metabolic crisis in traumatic brain injury: what does it mean?
    Journal of neurotrauma, 2014, Oct-15, Volume: 31, Issue:20

    Topics: Brain; Brain Chemistry; Brain Injuries; Humans; Lactic Acid; Microdialysis; Pyruvic Acid

2014
Lactate and the lactate-to-pyruvate molar ratio cannot be used as independent biomarkers for monitoring brain energetic metabolism: a microdialysis study in patients with traumatic brain injuries.
    PloS one, 2014, Volume: 9, Issue:7

    Topics: Adult; Biomarkers; Brain Injuries; Energy Metabolism; Female; Glucose; Humans; Lactic Acid; Male; Mi

2014
Detecting brain injury in neonatal hypoxic ischemic encephalopathy: closing the gap between experimental and clinical research.
    Experimental neurology, 2014, Volume: 261

    Topics: Analysis of Variance; Animals; Animals, Newborn; Blood Pressure; Brain Injuries; Disease Models, Ani

2014
Cerebral Glucose Metabolism and Sedation in Brain-injured Patients: A Microdialysis Study.
    Journal of neurosurgical anesthesiology, 2015, Volume: 27, Issue:3

    Topics: Adult; Aged; Brain; Brain Injuries; Dose-Response Relationship, Drug; Female; Glucose; Glutamic Acid

2015
Endogenous Nutritive Support after Traumatic Brain Injury: Peripheral Lactate Production for Glucose Supply via Gluconeogenesis.
    Journal of neurotrauma, 2015, Jun-01, Volume: 32, Issue:11

    Topics: Adolescent; Adult; Brain Injuries; Female; Gluconeogenesis; Glucose; Humans; Lactic Acid; Male; Midd

2015
Glycolysis and the pentose phosphate pathway after human traumatic brain injury: microdialysis studies using 1,2-(13)C2 glucose.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015, Volume: 35, Issue:1

    Topics: Adolescent; Adult; Aged; Brain; Brain Injuries; Carbon Isotopes; Case-Control Studies; Female; Gluco

2015
Lactate: brain fuel in human traumatic brain injury: a comparison with normal healthy control subjects.
    Journal of neurotrauma, 2015, Jun-01, Volume: 32, Issue:11

    Topics: Adolescent; Adult; Brain; Brain Injuries; Female; Humans; Lactic Acid; Male; Middle Aged; Young Adul

2015
Curcumin, encapsulated in nano-sized PLGA, down-regulates nuclear factor κB (p65) and subarachnoid hemorrhage induced early brain injury in a rat model.
    Brain research, 2015, May-22, Volume: 1608

    Topics: Analysis of Variance; Animals; Biocompatible Materials; Brain Injuries; Caspase 3; Caspase 9; Curcum

2015
Neuroenergetic Response to Prolonged Cerebral Glucose Depletion after Severe Brain Injury and the Role of Lactate.
    Journal of neurotrauma, 2015, Oct-15, Volume: 32, Issue:20

    Topics: Adult; Blood Glucose; Brain; Brain Injuries; Female; Glucose; Humans; Lactic Acid; Male; Microdialys

2015
Low-level light in combination with metabolic modulators for effective therapy of injured brain.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015, Volume: 35, Issue:9

    Topics: Animals; Brain Injuries; Cell Hypoxia; Cell Line, Tumor; Hippocampus; Humans; Lactic Acid; Light; Me

2015
PLGA Nanoparticles Loaded Cerebrolysin: Studies on Their Preparation and Investigation of the Effect of Storage and Serum Stability with Reference to Traumatic Brain Injury.
    Molecular neurobiology, 2015, Volume: 52, Issue:2

    Topics: Amino Acids; Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Delayed-Action Preparations;

2015
Neuroprotective efficacy of decompressive craniectomy after controlled cortical impact injury in rats: An MRI study.
    Brain research, 2015, Oct-05, Volume: 1622

    Topics: Animals; Aspartic Acid; Brain; Brain Edema; Brain Injuries; Choline; Creatine; Decompressive Craniec

2015
Fueling the Brain--a New Role in Lactate Metabolism.
    World neurosurgery, 2015, Volume: 84, Issue:3

    Topics: Brain; Brain Chemistry; Brain Injuries; Energy Metabolism; Humans; Lactic Acid; Nutritional Support

2015
Polysorbate 80-coated PLGA nanoparticles improve the permeability of acetylpuerarin and enhance its brain-protective effects in rats.
    The Journal of pharmacy and pharmacology, 2015, Volume: 67, Issue:12

    Topics: Animals; Apoptosis; Area Under Curve; Biotransformation; Blood-Brain Barrier; Brain; Brain Injuries;

2015
Effect of PLGA NP size on efficiency to target traumatic brain injury.
    Journal of controlled release : official journal of the Controlled Release Society, 2016, Feb-10, Volume: 223

    Topics: Animals; Benzenesulfonates; Brain; Brain Injuries; Cell Line, Tumor; Drug Carriers; Female; Fluoresc

2016
Metabolic crisis occurs with seizures and periodic discharges after brain trauma.
    Annals of neurology, 2016, Volume: 79, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Brain Injuries; Electroencephalography; Female; Humans; Lactic Acid;

2016
Clinical research on postoperative efficacy and related factors of early simulation hyperbaric oxygen therapy for severe craniocerebral injury.
    Pakistan journal of pharmaceutical sciences, 2016, Volume: 29, Issue:1 Suppl

    Topics: Adult; Age Factors; Aged; Blood Glucose; Brain Injuries; Computer Simulation; Critical Care; Female;

2016
Neuroprotective actions of taurine on hypoxic-ischemic brain damage in neonatal rats.
    Brain research bulletin, 2016, Volume: 124

    Topics: Animals; Animals, Newborn; Apoptosis Inducing Factor; Brain Infarction; Brain Injuries; Female; Glut

2016
Early rehabilitation aggravates brain damage after stroke via enhanced activation of nicotinamide adenine dinucleotide phosphate oxidase (NOX).
    Brain research, 2016, 10-01, Volume: 1648, Issue:Pt A

    Topics: Animals; Apoptosis; Brain Injuries; Cerebral Cortex; Glucose Transporter Type 1; Glucose Transporter

2016
Simultaneous monitoring of potassium, glucose and lactate during spreading depolarization in the injured human brain - Proof of principle of a novel real-time neurochemical analysis system, continuous online microdialysis.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017, Volume: 37, Issue:5

    Topics: Brain Injuries; Coma; Cortical Spreading Depression; Electrocorticography; Glucose; Humans; Lactic A

2017
Hyperoxia results in increased aerobic metabolism following acute brain injury.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017, Volume: 37, Issue:8

    Topics: Blood Flow Velocity; Brain; Brain Injuries; Cerebrovascular Circulation; Cytochromes c; Energy Metab

2017
Amyloid-beta dynamics correlate with neurological status in the injured human brain.
    Science (New York, N.Y.), 2008, Aug-29, Volume: 321, Issue:5893

    Topics: Amyloid beta-Peptides; Brain; Brain Injuries; Extracellular Fluid; Glasgow Coma Scale; Glucose; Huma

2008
Persistent metabolic crisis as measured by elevated cerebral microdialysis lactate-pyruvate ratio predicts chronic frontal lobe brain atrophy after traumatic brain injury.
    Critical care medicine, 2008, Volume: 36, Issue:10

    Topics: Adolescent; Adult; Atrophy; Biomarkers; Brain Diseases; Brain Injuries; Chronic Disease; Cohort Stud

2008
Acute subdural hematoma in pigs: role of volume on multiparametric neuromonitoring and histology.
    Journal of neurotrauma, 2008, Volume: 25, Issue:9

    Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Evoked Potentials, Somatosensor

2008
Nonischemic energy metabolic crisis in acute brain injury.
    Critical care medicine, 2008, Volume: 36, Issue:10

    Topics: Biomarkers; Brain Injuries; Critical Care; Critical Illness; Energy Metabolism; Female; Glasgow Coma

2008
Neuroprotective effects of erythropoietin on acute metabolic and pathological changes in experimentally induced neurotrauma.
    Journal of neurosurgery, 2008, Volume: 109, Issue:4

    Topics: Acute Disease; Animals; Brain Injuries; Disease Models, Animal; Energy Metabolism; Erythropoietin; G

2008
Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury: a microdialysis study.
    Critical care medicine, 2008, Volume: 36, Issue:12

    Topics: Adult; Aged; Blood Glucose; Brain; Brain Injuries; Female; Glucose; Hospitals, University; Humans; H

2008
Effect of hypoperfusion and the protein C pathway on the early coagulopathy after traumatic brain injury.
    The Journal of trauma, 2008, Volume: 65, Issue:6

    Topics: Adult; Blood Coagulation Disorders; Brain Injuries; Brain Ischemia; Hemoperitoneum; Humans; Lactic A

2008
A combined microdialysis and FDG-PET study of glucose metabolism in head injury.
    Acta neurochirurgica, 2009, Volume: 151, Issue:1

    Topics: Adolescent; Adult; Aged; Biomarkers; Brain; Brain Injuries; Energy Metabolism; Extracellular Fluid;

2009
IFN-gamma and IL-4 differentially shape metabolic responses and neuroprotective phenotype of astrocytes.
    Journal of neurochemistry, 2009, Volume: 108, Issue:5

    Topics: Animals; Astrocytes; Brain; Brain Injuries; Cell Hypoxia; Cells, Cultured; Dose-Response Relationshi

2009
Dual microdialysis probe monitoring for patients with traumatic brain injury.
    Acta neurochirurgica. Supplement, 2008, Volume: 102

    Topics: Brain Injuries; Electrochemistry; Extracellular Space; Female; Glutamic Acid; Humans; Lactic Acid; M

2008
Delayed cerebral oxidative glucose metabolism after traumatic brain injury in young rats.
    Journal of neurochemistry, 2009, Volume: 109 Suppl 1

    Topics: Amino Acids; Animals; Aspartic Acid; Brain Edema; Brain Injuries; Glucose; Glutamic Acid; Glutamine;

2009
Adaptation to oxidative challenge induced by chronic physical exercise prevents Na+,K+-ATPase activity inhibition after traumatic brain injury.
    Brain research, 2009, Jul-07, Volume: 1279

    Topics: Analysis of Variance; Animals; Body Weight; Brain Injuries; Cerebral Cortex; Lactic Acid; Male; Oxid

2009
Improving the recovery of S100B protein in cerebral microdialysis: implications for multimodal monitoring in neurocritical care.
    Journal of neuroscience methods, 2009, Jun-30, Volume: 181, Issue:1

    Topics: Brain Injuries; Catheterization; Enzyme-Linked Immunosorbent Assay; Extracellular Fluid; Glucose; Hu

2009
Enzyme logic gates for the digital analysis of physiological level upon injury.
    Biosensors & bioelectronics, 2009, Aug-15, Volume: 24, Issue:12

    Topics: Biomarkers; Biosensing Techniques; Brain Injuries; Computers, Molecular; Diagnosis, Computer-Assiste

2009
Metabolic and histologic effects of sodium pyruvate treatment in the rat after cortical contusion injury.
    Journal of neurotrauma, 2009, Volume: 26, Issue:7

    Topics: Analysis of Variance; Animals; Brain; Brain Injuries; Cell Count; Glucose; Lactic Acid; Male; Microd

2009
The human brain utilizes lactate via the tricarboxylic acid cycle: a 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study.
    Brain : a journal of neurology, 2009, Volume: 132, Issue:Pt 10

    Topics: Acetates; Adolescent; Adult; Brain; Brain Chemistry; Brain Injuries; Citric Acid Cycle; Energy Metab

2009
Temporal and regional changes after focal traumatic brain injury.
    Journal of neurotrauma, 2010, Volume: 27, Issue:1

    Topics: Animals; Aspartic Acid; Brain; Brain Edema; Brain Injuries; Brain Mapping; Cerebral Cortex; Choline;

2010
Brain tissue lactate elevations predict episodes of intracranial hypertension in patients with traumatic brain injury.
    Journal of the American College of Surgeons, 2009, Volume: 209, Issue:4

    Topics: Adolescent; Adult; Aged; Area Under Curve; Australia; Biomarkers; Brain; Brain Injuries; Dermatitis,

2009
Prognosis for severe traumatic brain injury patients treated with bilateral decompressive craniectomy.
    Acta neurochirurgica. Supplement, 2010, Volume: 106

    Topics: Brain Injuries; Decompressive Craniectomy; Disability Evaluation; Female; Functional Laterality; Gla

2010
Brain metabolism is significantly impaired at blood glucose below 6 mM and brain glucose below 1 mM in patients with severe traumatic brain injury.
    Critical care (London, England), 2010, Volume: 14, Issue:1

    Topics: Adolescent; Adult; Blood Glucose; Brain; Brain Injuries; Female; Glutamic Acid; Humans; Insulin; Int

2010
Dynamic metabolic response to multiple spreading depolarizations in patients with acute brain injury: an online microdialysis study.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010, Volume: 30, Issue:7

    Topics: Adult; Aged; Area Under Curve; Brain; Brain Injuries; Craniotomy; Electroencephalography; Female; Gl

2010
Metabolic crisis after traumatic brain injury is associated with a novel microdialysis proteome.
    Neurocritical care, 2010, Volume: 12, Issue:3

    Topics: Blood Glucose; Brain; Brain Injuries; Brain Ischemia; Cerebral Hemorrhage, Traumatic; Energy Metabol

2010
Traumatic brain injury and metabolism.
    Journal of neurosurgery, 2010, Volume: 112, Issue:6

    Topics: Blood Flow Velocity; Blood Glucose; Brain; Brain Injuries; Craniotomy; Decompression, Surgical; Ener

2010
Moderate Ringer's lactate solution resuscitation yields best neurological outcome in controlled hemorrhagic shock combined with brain injury in rats.
    Shock (Augusta, Ga.), 2010, Volume: 34, Issue:1

    Topics: Animals; Brain; Brain Injuries; Isotonic Solutions; Lactic Acid; Male; Rats; Rats, Inbred Lew; Ringe

2010
Insulin differentially influences brain glucose and lactate in traumatic brain injured patients.
    Minerva anestesiologica, 2010, Volume: 76, Issue:11

    Topics: Adolescent; Adult; Blood Glucose; Brain Chemistry; Brain Injuries; Female; Glucose; Humans; Hypoglyc

2010
[Is lactate a good indicator of brain tissue hypoxia in the acute phase of traumatic brain injury? Results of a pilot study in 21 patients].
    Neurocirugia (Asturias, Spain), 2010, Volume: 21, Issue:4

    Topics: Adult; Biomarkers; Brain Injuries; Diagnosis, Differential; Energy Metabolism; Glucose; Humans; Hypo

2010
Post-traumatic hypoxia exacerbates brain tissue damage: analysis of axonal injury and glial responses.
    Journal of neurotrauma, 2010, Volume: 27, Issue:11

    Topics: Amyloid beta-Protein Precursor; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Bl

2010
Metabolic effects of a late hypotensive insult combined with reduced intracranial compliance following traumatic brain injury in the rat.
    Upsala journal of medical sciences, 2010, Volume: 115, Issue:4

    Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Glycerol; Hypotension; Hypoxant

2010
Cerebral lactic acid and phosphates in concussion.
    Federation proceedings, 1946, Volume: 5, Issue:1

    Topics: Brain; Brain Concussion; Brain Injuries; Lactic Acid; Phosphates

1946
Cerebral glucose metabolism after traumatic brain injury in the rat studied by 13C-glucose and microdialysis.
    Acta neurochirurgica, 2011, Volume: 153, Issue:3

    Topics: Anaerobiosis; Animals; Blood Glucose; Brain Damage, Chronic; Brain Injuries; Carbon Radioisotopes; E

2011
Cerebral microdialysis in acutely brain-injured patients with spreading depolarizations.
    Acta neurochirurgica. Supplement, 2011, Volume: 110, Issue:Pt 1

    Topics: Adult; Brain Injuries; Cerebral Cortex; Cortical Spreading Depression; Electroencephalography; Femal

2011
Alterations in cerebral oxidative metabolism following traumatic brain injury.
    Neurocritical care, 2011, Volume: 14, Issue:1

    Topics: Brain; Brain Injuries; Female; Humans; Lactic Acid; Microdialysis; Oxygen; Pyruvic Acid; Tomography,

2011
Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients.
    Brain : a journal of neurology, 2011, Volume: 134, Issue:Pt 2

    Topics: Adult; Biomarkers; Brain Injuries; Cerebral Cortex; Extracellular Fluid; Female; Glasgow Coma Scale;

2011
Potential non-hypoxic/ischemic causes of increased cerebral interstitial fluid lactate/pyruvate ratio: a review of available literature.
    Neurocritical care, 2011, Volume: 15, Issue:3

    Topics: Aerobiosis; Anaerobiosis; Blood Glucose; Brain; Brain Injuries; Critical Care; Energy Metabolism; Ex

2011
Analysis of the changes in the oxidation of brain tissue cytochrome-c-oxidase in traumatic brain injury patients during hypercapnoea: a broadband NIRS study.
    Advances in experimental medicine and biology, 2011, Volume: 701

    Topics: Adult; Brain; Brain Injuries; Electron Transport Complex IV; Female; Humans; Hypercapnia; Lactic Aci

2011
Time course of recovery from cerebral vulnerability after severe traumatic brain injury: a microdialysis study.
    The Journal of trauma, 2011, Volume: 71, Issue:5

    Topics: Analysis of Variance; Biomarkers; Body Temperature; Brain Injuries; Extracellular Fluid; Female; Gla

2011
Lower extracellular glucose level prolonged in elderly patients with severe traumatic brain injury: a microdialysis study.
    Neurologia medico-chirurgica, 2011, Volume: 51, Issue:4

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Blood Glucose; Brain; Brain Chemistry; Brain Injuries;

2011
Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats.
    Neuroscience letters, 2011, Jul-25, Volume: 499, Issue:3

    Topics: Animals; Brain Edema; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Dose-Response Relatio

2011
Effects of a small acute subdural hematoma following traumatic brain injury on neuromonitoring, brain swelling and histology in pigs.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 2011, Volume: 47, Issue:3

    Topics: Animals; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; Evoked Po

2011
Arterial lactate above 2 mM is associated with increased brain lactate and decreased brain glucose in patients with severe traumatic brain injury.
    Minerva anestesiologica, 2012, Volume: 78, Issue:2

    Topics: Adolescent; Adult; Arteries; Brain; Brain Injuries; Female; Glucose; Humans; Injury Severity Score;

2012
Cerebral metabolism after early decompression craniotomy following controlled cortical impact injury in rats.
    Neurological research, 2011, Volume: 33, Issue:8

    Topics: Animals; Brain Injuries; Cerebral Cortex; Craniotomy; Decompression, Surgical; Disease Models, Anima

2011
Lactate: a friendly fuel for the injured brain?
    Minerva anestesiologica, 2012, Volume: 78, Issue:2

    Topics: Brain; Brain Injuries; Female; Glucose; Humans; Lactic Acid; Male

2012
Brain tissue oxygenation and cerebral perfusion pressure thresholds of ischemia in a standardized pig brain death model.
    Neurocritical care, 2012, Volume: 16, Issue:3

    Topics: Animals; Blood Pressure; Brain; Brain Death; Brain Injuries; Brain Ischemia; Catheterization; Cerebr

2012
Early cerebral metabolic crisis after TBI influences outcome despite adequate hemodynamic resuscitation.
    Neurocritical care, 2012, Volume: 17, Issue:1

    Topics: Adult; Blood Pressure; Brain; Brain Diseases, Metabolic; Brain Injuries; Cardiopulmonary Resuscitati

2012
'Long' pressure reactivity index (L-PRx) as a measure of autoregulation correlates with outcome in traumatic brain injury patients.
    Acta neurochirurgica, 2012, Volume: 154, Issue:9

    Topics: Adult; Algorithms; Arterial Pressure; Blood Glucose; Brain; Brain Injuries; Disability Evaluation; F

2012
The frontal lobe and thalamus have different sensitivities to hypoxia-hypotension after traumatic brain injury: a microdialysis study in rats.
    Journal of neurotrauma, 2012, Dec-10, Volume: 29, Issue:18

    Topics: Animals; Blood Pressure; Brain Injuries; Cerebrovascular Circulation; Energy Metabolism; Frontal Lob

2012
Normobaric hyperoxia does not change optical scattering or pathlength but does increase oxidised cytochrome C oxidase concentration in patients with brain injury.
    Advances in experimental medicine and biology, 2013, Volume: 765

    Topics: Adult; Aged; Brain Injuries; Cerebrovascular Circulation; Electron Transport Complex IV; Female; Hem

2013
The neuroprotective effect of lactate is not due to improved glutamate uptake after controlled cortical impact in rats.
    Journal of neurotrauma, 2012, Aug-10, Volume: 29, Issue:12

    Topics: Animals; Brain Chemistry; Brain Injuries; Cerebral Cortex; Cerebrovascular Circulation; Chromatograp

2012
Effects of the neurological wake-up test on clinical examination, intracranial pressure, brain metabolism and brain tissue oxygenation in severely brain-injured patients.
    Critical care (London, England), 2012, Nov-27, Volume: 16, Issue:6

    Topics: Adult; Brain; Brain Chemistry; Brain Injuries; Deep Sedation; Female; Glucose; Hemodynamics; Humans;

2012
Changes in cerebral glycolytic activity during transport of critically ill neurotrauma patients measured with microdialysis.
    Journal of neurology, 2002, Volume: 249, Issue:6

    Topics: Adolescent; Aged; Brain Injuries; Cerebral Cortex; Cerebrovascular Circulation; Critical Care; Criti

2002
Traumatic brain injury and subarachnoid hemorrhage: in vivo occult pathology demonstrated by magnetic resonance spectroscopy may not be "ischaemic". A primary study and review of the literature.
    Acta neurochirurgica, 2002, Volume: 144, Issue:9

    Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Injuries; Brain Ischemia; Child; Choline; Creatine; C

2002
Brain alkaline intracellular pH after neonatal encephalopathy.
    Annals of neurology, 2002, Volume: 52, Issue:6

    Topics: Alkalosis; Analysis of Variance; Brain; Brain Injuries; Creatine; Follow-Up Studies; Humans; Hydroge

2002
Correlation between blood glucose concentration and glucose concentration in subcutaneous adipose tissue evaluated with microdialysis during intensive care.
    Scandinavian journal of clinical and laboratory investigation, 2002, Volume: 62, Issue:4

    Topics: Adipose Tissue; Blood Glucose; Brain Injuries; Critical Care; Energy Metabolism; Glycerol; Humans; H

2002
Does acute hyperventilation cause cerebral ischemia in severely head-injured patients?
    Critical care medicine, 2002, Volume: 30, Issue:12

    Topics: Brain Injuries; Brain Ischemia; Glutamic Acid; Humans; Hyperventilation; Lactic Acid; Respiration, A

2002
Effects of ganglioside GM1 on reduction of brain edema and amelioration of cerebral metabolism after traumatic brain injury.
    Chinese journal of traumatology = Zhonghua chuang shang za zhi, 2003, Volume: 6, Issue:1

    Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Hexosyltransferases; Lactic Aci

2003
Predicting neuropsychologic outcome after traumatic brain injury in children.
    Pediatric neurology, 2003, Volume: 28, Issue:2

    Topics: Adolescent; Adult; Brain Chemistry; Brain Injuries; Child; Child, Preschool; Electroencephalography;

2003
Persistently low extracellular glucose correlates with poor outcome 6 months after human traumatic brain injury despite a lack of increased lactate: a microdialysis study.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2003, Volume: 23, Issue:7

    Topics: Adult; Brain; Brain Injuries; Extracellular Space; Female; Glasgow Coma Scale; Glucose; Humans; Lact

2003
Effects of LY379268, a selective group II metabotropic glutamate receptor agonist on EEG activity, cortical perfusion, tissue damage, and cortical glutamate, glucose, and lactate levels in brain-injured rats.
    Journal of neurotrauma, 2003, Volume: 20, Issue:4

    Topics: Amino Acids; Animals; Brain Edema; Brain Injuries; Bridged Bicyclo Compounds, Heterocyclic; Cerebral

2003
L-glutamate decreases glucose utilization by rat cortical astrocytes.
    Neuroscience letters, 2003, Sep-11, Volume: 348, Issue:2

    Topics: Animals; Animals, Newborn; Astrocytes; Brain Injuries; Cell Hypoxia; Cells, Cultured; Cerebral Corte

2003
Metabolic changes in the vicinity of brain contusions: a proton magnetic resonance spectroscopy and histology study.
    Journal of neurotrauma, 2003, Volume: 20, Issue:8

    Topics: Animals; Aspartic Acid; Biomarkers; Brain Injuries; Choline; Creatine; Functional Laterality; Glutam

2003
Energy dysfunction as a predictor of outcome after moderate or severe head injury: indices of oxygen, glucose, and lactate metabolism.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2003, Volume: 23, Issue:10

    Topics: Adult; Brain; Brain Injuries; Cerebrovascular Circulation; Cohort Studies; Energy Metabolism; Female

2003
Metabolic changes during impending and manifest cerebral hypoxia in traumatic brain injury.
    British journal of neurosurgery, 2003, Volume: 17, Issue:4

    Topics: Adolescent; Adult; Aged; Brain; Brain Injuries; Female; Glutamic Acid; Humans; Hypoxia, Brain; Lacti

2003
Moderate controlled cortical contusion in pigs: effects on multi-parametric neuromonitoring and clinical relevance.
    Journal of neurotrauma, 2003, Volume: 20, Issue:12

    Topics: Animals; Body Temperature; Brain Edema; Brain Injuries; Disease Models, Animal; Glucose; Glutamic Ac

2003
Creatine-enhanced diet alters levels of lactate and free fatty acids after experimental brain injury.
    Neurochemical research, 2004, Volume: 29, Issue:2

    Topics: Animals; Brain; Brain Injuries; Creatine; Diet; Dietary Supplements; Dose-Response Relationship, Dru

2004
Preoperative brain injury in newborns with transposition of the great arteries.
    The Annals of thoracic surgery, 2004, Volume: 77, Issue:5

    Topics: Brain Injuries; Cardiopulmonary Bypass; Choline; Gestational Age; Humans; Infant, Newborn; Lactic Ac

2004
Assessment of jugular blood oxygen and lactate indices for detection of cerebral ischemia and prognosis.
    Journal of neurosurgical anesthesiology, 2004, Volume: 16, Issue:3

    Topics: Brain Injuries; Brain Ischemia; Coma; Glasgow Coma Scale; Humans; Intracranial Aneurysm; Jugular Vei

2004
Effects of norepinephrine depletion in rats during cerebral post-ischemic reperfusion.
    Neurotoxicology, 2004, Volume: 25, Issue:5

    Topics: Animals; Benzylamines; Brain Chemistry; Brain Injuries; Brain Ischemia; Cerebral Cortex; Coloring Ag

2004
In vivo neuroprotective adaptation of the glutamate/glutamine cycle to neuronal death.
    Hippocampus, 2004, Volume: 14, Issue:5

    Topics: Animals; Apoptosis; Brain; Brain Injuries; Cell Death; Cell Survival; Denervation; Disease Models, A

2004
Patterns of energy substrates during ischemia measured in the brain by microdialysis.
    Journal of neurotrauma, 2004, Volume: 21, Issue:7

    Topics: Adult; Brain Injuries; Brain Ischemia; Female; Glasgow Coma Scale; Glucose; Glutamic Acid; Humans; H

2004
Influence of oxygen therapy on glucose-lactate metabolism after diffuse brain injury.
    Journal of neurosurgery, 2004, Volume: 101, Issue:2

    Topics: Animals; Blood Gas Analysis; Blood Glucose; Blood Pressure; Body Temperature; Brain Injuries; Carbon

2004
Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study.
    Journal of neurosurgery, 2004, Volume: 101, Issue:3

    Topics: Adolescent; Adult; Aged; Blood Glucose; Brain; Brain Injuries; Cohort Studies; Critical Care; Energy

2004
Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study.
    Journal of neurosurgery, 2004, Volume: 101, Issue:3

    Topics: Adolescent; Adult; Aged; Blood Glucose; Brain; Brain Injuries; Cohort Studies; Critical Care; Energy

2004
Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study.
    Journal of neurosurgery, 2004, Volume: 101, Issue:3

    Topics: Adolescent; Adult; Aged; Blood Glucose; Brain; Brain Injuries; Cohort Studies; Critical Care; Energy

2004
Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study.
    Journal of neurosurgery, 2004, Volume: 101, Issue:3

    Topics: Adolescent; Adult; Aged; Blood Glucose; Brain; Brain Injuries; Cohort Studies; Critical Care; Energy

2004
Cerebral vascular and metabolic response to sustained systemic inflammation in ovine traumatic brain injury.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2004, Volume: 24, Issue:12

    Topics: Animals; Blood Glucose; Body Temperature; Brain; Brain Injuries; Carbon Dioxide; Cerebrovascular Cir

2004
Gender associations with cerebrospinal fluid glutamate and lactate/pyruvate levels after severe traumatic brain injury.
    Critical care medicine, 2005, Volume: 33, Issue:2

    Topics: Adult; Brain Injuries; Female; Glasgow Coma Scale; Glutamic Acid; Humans; Hypothermia, Induced; Lact

2005
Seizures induced in immature rats by homocysteic acid and the associated brain damage are prevented by group II metabotropic glutamate receptor agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate.
    Experimental neurology, 2005, Volume: 192, Issue:2

    Topics: Amino Acids; Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Brain; Brain Chemistry; B

2005
Intracerebral microdialysis in severe brain trauma: the importance of catheter location.
    Journal of neurosurgery, 2005, Volume: 102, Issue:3

    Topics: Adult; Aged; Brain Injuries; Catheters, Indwelling; Child; Female; Glucose; Humans; Lactic Acid; Mal

2005
Elevated lactate as an early marker of brain injury in inflicted traumatic brain injury.
    Pediatric radiology, 2005, Volume: 35, Issue:7

    Topics: Aspartic Acid; Brain Chemistry; Brain Injuries; Critical Care; Female; Fractures, Bone; Frontal Lobe

2005
Detection of the inhibitory neurotransmitter GABA in macrophages by magnetic resonance spectroscopy.
    Journal of leukocyte biology, 2005, Volume: 78, Issue:2

    Topics: Amino Acids; Animals; Biomarkers; Brain Injuries; Cell Communication; Cell Extracts; Cell Line; Cell

2005
Effects of cocaine in an experimental model of traumatic brain injury.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2005, Volume: 12, Issue:6

    Topics: Animals; Blood Pressure; Brain Injuries; Cardiac Output; Cerebrovascular Circulation; Cocaine-Relate

2005
Concurrent monitoring of cerebral electrophysiology and metabolism after traumatic brain injury: an experimental and clinical study.
    Journal of neurotrauma, 2005, Volume: 22, Issue:7

    Topics: Action Potentials; Adult; Animals; Brain Diseases, Metabolic; Brain Injuries; Cerebral Cortex; Disea

2005
[Effect of focal hypothermia on traumatic brain edema and the content of lactic acid in the brain tissue in rats].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2004, Volume: 29, Issue:6

    Topics: Animals; Brain Edema; Brain Injuries; Hypothermia, Induced; Lactic Acid; Male; Random Allocation; Ra

2004
Monitoring of cerebral blood flow and metabolism in traumatic brain injury.
    Journal of neurotrauma, 2005, Volume: 22, Issue:9

    Topics: Adult; Brain; Brain Injuries; Cerebrovascular Circulation; Glucose; Humans; Lactic Acid; Oxygen Cons

2005
Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury.
    Journal of neuroscience research, 2005, Nov-01, Volume: 82, Issue:3

    Topics: Age Factors; Aging; Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Energy Metabol

2005
Upregulation of pentose phosphate pathway and preservation of tricarboxylic acid cycle flux after experimental brain injury.
    Journal of neurotrauma, 2005, Volume: 22, Issue:10

    Topics: Animals; Brain Injuries; Citric Acid Cycle; Disease Models, Animal; Glucose; Glutamic Acid; Glutamin

2005
Cerebral acid-base homeostasis after severe traumatic brain injury.
    Journal of neurosurgery, 2005, Volume: 103, Issue:4

    Topics: Acid-Base Equilibrium; Adult; Brain Chemistry; Brain Injuries; Carbon Dioxide; Cell Death; Female; H

2005
Intracerebral microdialysis in neurosurgical intensive care patients utilising catheters with different molecular cut-off (20 and 100 kD).
    Acta neurochirurgica, 2006, Volume: 148, Issue:3

    Topics: Brain Chemistry; Brain Injuries; Catheters, Indwelling; Cerebral Cortex; Coma; Critical Care; Extrac

2006
[Influence of temperature on extracellular glucose and lactate after traumatic brain injury].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2006, Volume: 28, Issue:2

    Topics: Adult; Body Temperature; Brain Injuries; Extracellular Space; Female; Glucose; Humans; Lactic Acid;

2006
Quantitation of ischemic events after severe traumatic brain injury in humans: a simple scoring system.
    Journal of neurosurgical anesthesiology, 2006, Volume: 18, Issue:3

    Topics: Adult; Age Factors; Brain Chemistry; Brain Injuries; Brain Ischemia; Extracellular Fluid; Female; Gl

2006
Increased lactate levels impair the coagulation system--a potential contributing factor to progressive hemorrhage after traumatic brain injury.
    Journal of neurosurgical anesthesiology, 2006, Volume: 18, Issue:3

    Topics: Acidosis; Blood Coagulation; Brain Injuries; Buffers; Cerebral Hemorrhage, Traumatic; Disease Progre

2006
Low intracranial compliance increases the impact of intracranial volume insults to the traumatized brain: a microdialysis study in a traumatic brain injury rodent model.
    Neurosurgery, 2006, Volume: 59, Issue:2

    Topics: Animals; Biomarkers; Brain; Brain Chemistry; Brain Edema; Brain Injuries; Cell Membrane; Cerebral He

2006
High extracellular potassium and its correlates after severe head injury: relationship to high intracranial pressure.
    Neurosurgical focus, 2000, Volume: 8, Issue:1

    Topics: Adolescent; Adult; Astrocytes; Brain; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Cran

2000
Activin a release into cerebrospinal fluid in a subset of patients with severe traumatic brain injury.
    Journal of neurotrauma, 2006, Volume: 23, Issue:9

    Topics: Activins; Adolescent; Adult; Aged; Brain Injuries; Case-Control Studies; Female; Follistatin; Glutam

2006
Lactate, not glucose, up-regulates mitochondrial oxygen consumption both in sham and lateral fluid percussed rat brains.
    Neurosurgery, 2006, Volume: 59, Issue:5

    Topics: Animals; Brain; Brain Injuries; Cell Respiration; Dose-Response Relationship, Drug; Glucose; Lactic

2006
Pericontusional brain tissue exhibits persistent elevation of lactate/pyruvate ratio independent of cerebral perfusion pressure.
    Critical care medicine, 2007, Volume: 35, Issue:4

    Topics: Adolescent; Adult; Biomarkers; Brain; Brain Injuries; Cerebrovascular Circulation; Female; Glasgow C

2007
Heart sensitivity to electrolyte composition of perfusion solution of rats after severe brain injury.
    Bulletin of experimental biology and medicine, 2006, Volume: 141, Issue:6

    Topics: Animals; Blood Glucose; Blood Pressure; Brain Injuries; Calcium; Electrolytes; Hydrogen-Ion Concentr

2006
Synthes Award For Resident Research On Craniofacial And Brain Injury: effect of cyclosporin A, topiramate, or 100% oxygen as proposed "neuroprotective" therapies on the neurochemical analytes in patients with severe traumatic brain injury.
    Clinical neurosurgery, 2006, Volume: 53

    Topics: Adult; Awards and Prizes; Brain Injuries; Case-Control Studies; Cohort Studies; Cyclosporine; Fructo

2006
Sleeping Beauty: a tale still with an uncertain happy ending after head trauma.
    Critical care medicine, 2007, Volume: 35, Issue:4

    Topics: Biomarkers; Brain; Brain Injuries; Cerebrovascular Circulation; Glasgow Coma Scale; Hospitals, Unive

2007
Identifying traumatic brain injury in patients with isolated head trauma: are arterial lactate and base deficit as helpful as in polytrauma?
    Emergency medicine journal : EMJ, 2007, Volume: 24, Issue:5

    Topics: Acid-Base Imbalance; Adult; Biomarkers; Brain Injuries; Cohort Studies; Female; Humans; Lactic Acid;

2007
Changes in cortical and subcortical energy metabolism after repetitive and single controlled cortical impact injury in the mouse.
    Journal of molecular neuroscience : MN, 2007, Volume: 31, Issue:2

    Topics: Adenosine Triphosphate; Animals; Brain Injuries; Cerebral Cortex; Energy Metabolism; Glucose; Lactic

2007
Effect of brain cooling on brain ischemia and damage markers after fluid percussion brain injury in rats.
    Shock (Augusta, Ga.), 2007, Volume: 28, Issue:3

    Topics: Animals; Behavior, Animal; Blood Pressure; Body Weight; Brain; Brain Injuries; Brain Ischemia; Cereb

2007
The fate of glucose during the period of decreased metabolism after fluid percussion injury: a 13C NMR study.
    Journal of neurotrauma, 2007, Volume: 24, Issue:7

    Topics: Animals; Brain Injuries; Carbon Isotopes; Cerebral Cortex; Down-Regulation; Free Radicals; Glucose;

2007
Poly(epsilon-caprolactone) and poly (L-lactic-co-glycolic acid) degradable polymer sponges attenuate astrocyte response and lesion growth in acute traumatic brain injury.
    Tissue engineering, 2007, Volume: 13, Issue:10

    Topics: Absorbable Implants; Animals; Astrocytes; Biocompatible Materials; Brain Injuries; Female; Lactic Ac

2007
Effect of lactate therapy upon cognitive deficits after traumatic brain injury in the rat.
    Acta neurochirurgica, 2007, Volume: 149, Issue:9

    Topics: Adenosine Triphosphate; Animals; Brain Injuries; Cerebral Cortex; Cognition; Cognition Disorders; In

2007
Online correlation of spontaneous arterial and intracranial pressure fluctuations in patients with diffuse severe head injury.
    Neurological research, 2007, Volume: 29, Issue:5

    Topics: Adolescent; Adult; Aged; Arteries; Blood Pressure; Brain Injuries; Female; Glucose; Humans; Intracra

2007
Cerebral arterio-venous pCO2 difference, estimated respiratory quotient, and early posttraumatic outcome: comparison with arterio-venous lactate and oxygen differences.
    Journal of neurosurgical anesthesiology, 2007, Volume: 19, Issue:4

    Topics: Adult; Brain Death; Brain Injuries; Brain Ischemia; Carbon Dioxide; Cerebrovascular Circulation; Fem

2007
Posttraumatic brain vulnerability to hypoxia-hypotension: the importance of the delay between brain trauma and secondary insult.
    Intensive care medicine, 2008, Volume: 34, Issue:3

    Topics: Animals; Brain; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; Gl

2008
Effect of hyperoxia on regional oxygenation and metabolism after severe traumatic brain injury: preliminary findings.
    Critical care medicine, 2008, Volume: 36, Issue:1

    Topics: Adolescent; Adult; Brain Injuries; Cerebrum; Female; Humans; Hyperoxia; Intracranial Pressure; Lacti

2008
Metabolic failure precedes intracranial pressure rises in traumatic brain injury: a microdialysis study.
    Acta neurochirurgica, 2008, Volume: 150, Issue:5

    Topics: Biomarkers; Brain; Brain Injuries; Glutamic Acid; Glycerol; Humans; Intracranial Hypertension; Lacti

2008
Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats.
    Journal of neurotrauma, 2008, Volume: 25, Issue:6

    Topics: Aging; Alanine; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Injuries; Cell Respiration; C

2008
[Effect of therapeutic hyperventilation on blood lactate concentration].
    Der Anaesthesist, 1983, Volume: 32, Issue:10

    Topics: Adult; Aged; Brain Injuries; Carbon Dioxide; Child; Child, Preschool; Female; Humans; Lactates; Lact

1983
[Role of cerebrospinal fluid lactic acid in the evaluation of cranial injuries. Review of the literature].
    Minerva anestesiologica, 1984, Volume: 50, Issue:5

    Topics: Brain Injuries; Glucose; Humans; Lactates; Lactic Acid; Prognosis; Pulmonary Gas Exchange

1984
Neurochemical monitoring and on-line pH measurements using brain microdialysis in patients in intensive care.
    Acta neurochirurgica. Supplementum, 1994, Volume: 60

    Topics: Acid-Base Equilibrium; Adult; Ascorbic Acid; Blood Glucose; Blood-Brain Barrier; Brain Edema; Brain

1994
Regional levels of lactate and norepinephrine after experimental brain injury.
    Journal of neurochemistry, 1994, Volume: 63, Issue:3

    Topics: Adenosine Triphosphate; Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Freezing;

1994
Cerebral lactate-oxygen index in acute brain injury with acute anemia: assessment of false versus true ischemia.
    Critical care medicine, 1994, Volume: 22, Issue:9

    Topics: Acute Disease; Adolescent; Adult; Aged; Anemia; Brain; Brain Injuries; Brain Ischemia; Cerebrovascul

1994
Lactated Ringer's solution alleviates brain trauma-precipitated lactic acidosis in hemorrhagic shock.
    Journal of neurotrauma, 1993,Fall, Volume: 10, Issue:3

    Topics: Acidosis, Lactic; Animals; Blood Glucose; Brain Injuries; Cerebral Hemorrhage; Gases; Hydrogen-Ion C

1993
Early ischaemia after severe head injury. Preliminary results in patients with diffuse brain injuries.
    Acta neurochirurgica, 1993, Volume: 122, Issue:3-4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Flow Velocity; Brain; Brain Concussion; Brain Dama

1993
Immunohistochemical studies with antibodies to neurofilament proteins on axonal damage in experimental focal lesions in rat.
    Journal of the neurological sciences, 1993, Volume: 117, Issue:1-2

    Topics: Animals; Axons; Biomarkers; Brain Injuries; Cerebral Infarction; Immunoenzyme Techniques; Lactates;

1993
Cerebral extraction of oxygen, lactate production, and perfusion pressure in gunshot wound to the head: case report.
    The Journal of trauma, 1996, Volume: 40, Issue:3

    Topics: Adult; Blood Gas Analysis; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Humans; Lact

1996
Proton MR spectroscopy after acute central nervous system injury: outcome prediction in neonates, infants, and children.
    Radiology, 1997, Volume: 202, Issue:2

    Topics: Adolescent; Aspartic Acid; Brain; Brain Diseases; Brain Injuries; Child; Choline; Discriminant Analy

1997
Effects of six weeks of chronic ethanol administration on lactic acid accumulation and high energy phosphate levels after experimental brain injury in rats.
    Journal of neurotrauma, 1997, Volume: 14, Issue:12

    Topics: Adenosine Triphosphate; Animals; Body Weight; Brain; Brain Injuries; Central Nervous System Depressa

1997
Comparison of brain tissue oxygen tension to microdialysis-based measures of cerebral ischemia in fatally head-injured humans.
    Journal of neurotrauma, 1998, Volume: 15, Issue:7

    Topics: Adult; Brain; Brain Death; Brain Injuries; Cations; Chromatography, High Pressure Liquid; Excitatory

1998
Involvement of reactive oxygen species in membrane phospholipid breakdown and energy perturbation after traumatic brain injury in the rat.
    Journal of neurotrauma, 1998, Volume: 15, Issue:7

    Topics: Analysis of Variance; Animals; Biomarkers; Brain Injuries; Disease Models, Animal; Disease Progressi

1998
Magnetic resonance spectroscopy of diffuse brain trauma in the pig.
    Journal of neurotrauma, 1998, Volume: 15, Issue:9

    Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Axons; Behavior, Animal; Brain Chemistry; Brain Inju

1998
Amphetamine administration improves neurochemical outcome of lateral fluid percussion brain injury in the rat.
    Brain research, 1998, Sep-07, Volume: 804, Issue:2

    Topics: Animals; Brain Chemistry; Brain Injuries; Central Nervous System Stimulants; Dextroamphetamine; Fatt

1998
Cerebral hemodynamic changes during sustained hypocapnia in severe head injury: can hyperventilation cause cerebral ischemia?
    Acta neurochirurgica. Supplement, 1998, Volume: 71

    Topics: Adolescent; Adult; Brain; Brain Injuries; Brain Ischemia; Carbon Dioxide; Female; Hemodynamics; Home

1998
Significance of multimodal cerebral monitoring under moderate therapeutic hypothermia for severe head injury.
    Acta neurochirurgica. Supplement, 1998, Volume: 71

    Topics: Adolescent; Adult; Aged; Blood Flow Velocity; Brain; Brain Edema; Brain Injuries; Child; Child, Pres

1998
Brain ischemia detected by tissue-PO2 measurement and the lactate-oxygen index in head injury.
    Acta neurochirurgica. Supplement, 1998, Volume: 71

    Topics: Brain; Brain Concussion; Brain Injuries; Brain Ischemia; Humans; Lactic Acid; Oxygen; Oxygen Consump

1998
Jugular bulb monitoring of cerebral oxygen metabolism in severe head injury: accuracy of unilateral measurements.
    Acta neurochirurgica. Supplement, 1998, Volume: 71

    Topics: Brain; Brain Injuries; Brain Ischemia; Coma; Dominance, Cerebral; Female; Humans; Jugular Veins; Lac

1998
Does growth hormone augment brain edema caused by brain injury? A study with a freeze brain injury model in the rat.
    The Journal of trauma, 1999, Volume: 46, Issue:2

    Topics: Animals; Blood Glucose; Body Water; Brain Chemistry; Brain Edema; Brain Injuries; Disease Models, An

1999
Regional changes in cerebral extracellular glucose and lactate concentrations following severe cortical impact injury and secondary ischemia in rats.
    Journal of neurotrauma, 1999, Volume: 16, Issue:3

    Topics: Acidosis, Lactic; Animals; Blood Gas Analysis; Body Temperature; Brain Chemistry; Brain Injuries; Br

1999
Extracellular lactate and glucose alterations in the brain after head injury measured by microdialysis.
    Critical care medicine, 1999, Volume: 27, Issue:9

    Topics: Adult; Analysis of Variance; Brain Injuries; Cerebral Cortex; Cerebrovascular Circulation; Female; G

1999
Lactate and traumatic brain injury.
    Critical care medicine, 1999, Volume: 27, Issue:9

    Topics: Brain Injuries; Humans; Jugular Veins; Lactic Acid; Magnetic Resonance Spectroscopy; Microdialysis;

1999
[Transcranial cytokine gradient and intestinal permeability in acute severe brain injury].
    Revista medica de Chile, 1999, Volume: 127, Issue:6

    Topics: Adult; Brain Injuries; Cytokines; Female; Humans; Interleukin-1; Interleukin-6; Intestinal Mucosa; L

1999
Secondary neurologic injury resulting from nonhypotensive hemorrhage combined with mild traumatic brain injury.
    Journal of neurotrauma, 1999, Volume: 16, Issue:9

    Topics: Animals; Blood Glucose; Brain Hemorrhage, Traumatic; Brain Injuries; Female; Hypotension; Intracrani

1999
Brain tissue oxygenation.
    Journal of neurosurgery, 1999, Volume: 91, Issue:6

    Topics: Blood Glucose; Brain; Brain Injuries; Energy Metabolism; Extracellular Space; Humans; Lactic Acid; O

1999
Glucose and lactate metabolism after severe human head injury: influence of excitatory neurotransmitters and injury type.
    Acta neurochirurgica. Supplement, 1999, Volume: 75

    Topics: Adult; Brain Injuries; Female; Glasgow Coma Scale; Glucose; Glutamic Acid; Humans; Lactic Acid; Male

1999
Evidence for time-dependent glutamate-mediated glycolysis in head-injured patients: a microdialysis study.
    Acta neurochirurgica. Supplement, 1999, Volume: 75

    Topics: Adult; Brain Injuries; Female; Glasgow Coma Scale; Glucose; Glutamic Acid; Glycolysis; Humans; Lacti

1999
Determinants of cerebral extracellular potassium after severe human head injury.
    Acta neurochirurgica. Supplement, 1999, Volume: 75

    Topics: Adolescent; Adult; Biomarkers; Brain; Brain Injuries; Extracellular Space; Female; Glasgow Coma Scal

1999
Effect of hypocapnea on CBF and extracellular intermediates of secondary brain injury.
    Acta neurochirurgica. Supplement, 1999, Volume: 75

    Topics: Brain; Brain Injuries; Carbon Dioxide; Chromatography, High Pressure Liquid; Extracellular Space; Gl

1999
Continuous monitoring of cerebrospinal fluid acid-base balance and oxygen metabolism in patients with severe head injury: pathophysiology and treatments for cerebral acidosis and ischemia.
    Acta neurochirurgica. Supplement, 1999, Volume: 75

    Topics: Acidosis; Adolescent; Adult; Brain Injuries; Brain Ischemia; Carbon Dioxide; Fever; Glasgow Coma Sca

1999
Monitoring by subcutaneous microdialysis in neurosurgical intensive care.
    Acta neurochirurgica. Supplement, 1999, Volume: 75

    Topics: Adolescent; Aged; Blood Glucose; Brain Injuries; Chromatography, High Pressure Liquid; Female; Gluta

1999
Peripheral plasma amino acid abnormalities in rehabilitation patients with severe brain injury.
    Archives of physical medicine and rehabilitation, 2000, Volume: 81, Issue:2

    Topics: Adolescent; Adult; Aged; Amino Acids; Biomarkers; Brain Injuries; Carnitine; Disability Evaluation;

2000
Brain lactate uptake increases at the site of impact after traumatic brain injury.
    Brain research, 2000, Apr-10, Volume: 861, Issue:2

    Topics: Animals; Blood-Brain Barrier; Brain Injuries; Cerebral Cortex; Hippocampus; Lactic Acid; Male; Rats;

2000
Microdialysis-based long-term measurements of energy-related metabolites in the rat brain following a fluid percussion trauma.
    Journal of neurotrauma, 2000, Volume: 17, Issue:5

    Topics: Animals; Brain Chemistry; Brain Injuries; Cerebral Cortex; Energy Metabolism; Extracellular Space; G

2000
Cerebral oxygenation and systemic trauma related factors determining neurological outcome after brain injury.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2000, Volume: 7, Issue:3

    Topics: Adolescent; Adult; APACHE; Brain Injuries; Catheterization, Peripheral; Female; Glasgow Coma Scale;

2000
Clinical cerebral microdialysis: a methodological study.
    Journal of neurosurgery, 2000, Volume: 93, Issue:1

    Topics: Adult; Blood Glucose; Brain Chemistry; Brain Injuries; Catheters, Indwelling; Chromatography, High P

2000
The impact of hypercarbia on the evolution of brain injury in a porcine model of traumatic brain injury and systemic hemorrhage.
    Journal of neurotrauma, 2001, Volume: 18, Issue:1

    Topics: Animals; Axons; Blood Pressure; Brain; Brain Injuries; Brain Ischemia; Carbon Dioxide; Cardiac Outpu

2001
Interstitial brain adenosine and xanthine increase during jugular venous oxygen desaturations in humans after traumatic brain injury.
    Critical care medicine, 2001, Volume: 29, Issue:2

    Topics: Adenosine; Adolescent; Adult; Blood Gas Analysis; Blood Glucose; Brain Chemistry; Brain Injuries; Ce

2001
Effects of magnesium sulfate on tissue lactate and malondialdehyde levels in experimental head trauma.
    Intensive care medicine, 2001, Volume: 27, Issue:1

    Topics: Analysis of Variance; Animals; Brain; Brain Injuries; Female; Lactic Acid; Lipid Peroxidation; Magne

2001
Changes in regional energy metabolism after closed head injury in the rat.
    Journal of molecular neuroscience : MN, 2001, Volume: 16, Issue:1

    Topics: Adenosine Triphosphate; Animals; Brain; Brain Injuries; Brain Ischemia; Encephalitis; Energy Metabol

2001
17beta-Estradiol reduces cortical lesion size in the glutamate excitotoxicity model by enhancing extracellular lactate: a new neuroprotective pathway.
    Brain research, 2001, May-18, Volume: 901, Issue:1-2

    Topics: Animals; Brain Injuries; Cerebral Cortex; Cerebral Infarction; Disease Models, Animal; Estradiol; Ex

2001
Effects of ethanol and naltrexone in a model of traumatic brain injury with hemorrhagic shock.
    Alcoholism, clinical and experimental research, 2001, Volume: 25, Issue:6

    Topics: Animals; Blood Pressure; Brain; Brain Injuries; Cardiac Output; Ethanol; Hydrogen-Ion Concentration;

2001
Interstitial lactate in the peritraumatic penumbra of rat brain.
    Acta neurochirurgica. Supplement, 2000, Volume: 76

    Topics: Animals; Brain Damage, Chronic; Brain Edema; Brain Injuries; Cerebral Cortex; Lactic Acid; Male; Nec

2000
Low extracellular (ECF) glucose affects the neurochemical profile in severe head-injured patients.
    Acta neurochirurgica. Supplement, 2000, Volume: 76

    Topics: Blood Glucose; Brain; Brain Edema; Brain Injuries; Carbon Dioxide; Critical Care; Energy Metabolism;

2000
On-line monitoring of substrate delivery and brain metabolism in head injury.
    Acta neurochirurgica. Supplement, 2000, Volume: 76

    Topics: Adolescent; Adult; Aged; Blood Glucose; Brain Injuries; Catheters, Indwelling; Energy Metabolism; Fe

2000
Substrate delivery and ionic balance disturbance after severe human head injury.
    Acta neurochirurgica. Supplement, 2000, Volume: 76

    Topics: Acid-Base Equilibrium; Brain; Brain Edema; Brain Injuries; Carbon Dioxide; Glutamic Acid; Humans; La

2000
Induced mitochondrial failure in the feline brain: implications for understanding acute post-traumatic metabolic events.
    Brain research, 2001, Jul-20, Volume: 908, Issue:1

    Topics: Animals; Brain; Brain Injuries; Carbon Dioxide; Cats; Cerebrovascular Circulation; Energy Metabolism

2001
Brain energy metabolism during controlled reduction of cerebral perfusion pressure in severe head injuries.
    Intensive care medicine, 2001, Volume: 27, Issue:7

    Topics: Adolescent; Adult; Aged; Biomarkers; Brain Injuries; Cerebrovascular Circulation; Child; Child, Pres

2001
Intracerebral microdialysis and bedside biochemical analysis in patients with fatal traumatic brain lesions.
    Acta anaesthesiologica Scandinavica, 2001, Volume: 45, Issue:8

    Topics: Adult; Aged; Brain; Brain Injuries; Brain Ischemia; Energy Metabolism; Female; Glucose; Glycerol; Hu

2001
Lactate reduces glutamate-induced neurotoxicity in rat cortex.
    Journal of neuroscience research, 2001, Dec-01, Volume: 66, Issue:5

    Topics: Animals; Brain Injuries; Cerebral Cortex; Drug Interactions; Extracellular Space; Glucose; Glutamic

2001
Monitoring arterio-venous differences of glucose and lactate in the anesthetized rat with or without brain damage with ultrafiltration and biosensor technology.
    Journal of neuroscience research, 2001, Dec-01, Volume: 66, Issue:5

    Topics: Anesthetics; Animals; Arteries; Biosensing Techniques; Blood Glucose; Brain; Brain Injuries; Cerebro

2001
Lactate administration attenuates cognitive deficits following traumatic brain injury.
    Brain research, 2002, Feb-22, Volume: 928, Issue:1-2

    Topics: Animals; Brain Chemistry; Brain Injuries; Cell Death; Cognition Disorders; Energy Metabolism; Hippoc

2002
Relationship between brain temperature, brain chemistry and oxygen delivery after severe human head injury: the effect of mild hypothermia.
    Neurological research, 2002, Volume: 24, Issue:2

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Body Temperature; Brain; Brain Chemistry; Brain Injuries; Ca

2002
Correlation between cerebral blood flow, substrate delivery, and metabolism in head injury: a combined microdialysis and triple oxygen positron emission tomography study.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2002, Volume: 22, Issue:6

    Topics: Adolescent; Adult; Brain; Brain Chemistry; Brain Injuries; Cerebrovascular Circulation; Female; Gluc

2002
Indomethacin (Confortid) in severe head injury and elevated intracranial pressure (ICP).
    Acta neurochirurgica. Supplementum, 1992, Volume: 55

    Topics: Adult; Blood Pressure; Body Temperature Regulation; Brain; Brain Injuries; Drug Administration Sched

1992
Estimating energy expenditure in traumatic brain injury: comparison of indirect calorimetry with predictive formulas.
    Neurosurgery, 1992, Volume: 31, Issue:2

    Topics: Adult; Blood Glucose; Blood Urea Nitrogen; Brain Injuries; Calorimetry, Indirect; Energy Intake; Ene

1992
Intravenous fluid tonicity: effect on intracranial pressure, cerebral blood flow, and cerebral oxygen delivery in focal brain injury.
    Journal of neurosurgery, 1992, Volume: 76, Issue:1

    Topics: Animals; Brain Injuries; Cerebrovascular Circulation; Hypotonic Solutions; Intracranial Pressure; Is

1992
The effect of age on glucose-modulated cerebral agonal glycolytic rates measured in vivo by 1H NMR spectroscopy.
    Pediatric research, 1991, Volume: 30, Issue:6

    Topics: Age Factors; Animals; Animals, Newborn; Blood Glucose; Brain; Brain Injuries; Brain Ischemia; Glycol

1991
[Study of the changes in carbohydrate metabolism as a diagnostic test of acute hypothalamic syndrome in severe cranio-cerebral trauma].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1990, Volume: 90, Issue:12

    Topics: Acid-Base Equilibrium; Acidosis; Acute Disease; Adolescent; Adult; Brain Injuries; Carbohydrate Meta

1990
The effects of indomethacin on intracranial pressure, cerebral blood flow and cerebral metabolism in patients with severe head injury and intracranial hypertension.
    Acta neurochirurgica, 1991, Volume: 108, Issue:3-4

    Topics: Adult; Blood Flow Velocity; Blood Pressure; Body Temperature; Brain; Brain Injuries; Cerebrovascular

1991
[Enzymes and metabolic products in the cerebrospinal fluid in acute craniocerebral trauma].
    Vrachebnoe delo, 1989, Issue:1

    Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Brain Injuries; Cerebrospinal Fluid; Clini

1989
Effects of hyperventilation, hypothermia, and altered blood viscosity on cerebral blood flow, cross-brain oxygen extraction, and cerebral metabolic rate for oxygen in cats.
    Critical care medicine, 1989, Volume: 17, Issue:9

    Topics: Animals; Blood Viscosity; Brain Injuries; Cats; Cerebrovascular Circulation; Hyperventilation; Hypot

1989
Production and clearance of lactate from brain tissue, cerebrospinal fluid, and serum following experimental brain injury.
    Journal of neurosurgery, 1988, Volume: 69, Issue:5

    Topics: Animals; Arteries; Blood Glucose; Brain; Brain Injuries; Cats; Female; Lactates; Lactic Acid; Magnet

1988
[Value of clinico-chemical studies of ventricular cerebrospinal fluid in patients with severe craniocerebral trauma].
    Zeitschrift fur medizinische Laboratoriumsdiagnostik, 1987, Volume: 28, Issue:3

    Topics: Brain Damage, Chronic; Brain Injuries; Humans; Lactates; Lactic Acid; Prognosis

1987
The predictive value of cerebral anaerobic metabolism with cerebral infarction after head injury.
    Journal of neurosurgery, 1987, Volume: 67, Issue:3

    Topics: Adult; Brain; Brain Injuries; Cerebral Infarction; Cerebrovascular Circulation; Female; Humans; Lact

1987
Hyperglycemia, cerebrospinal fluid lactic acidosis, and cerebral blood flow in severely head-injured patients.
    Neurosurgery, 1987, Volume: 21, Issue:1

    Topics: Acidosis; Adult; Blood Glucose; Brain; Brain Injuries; Cerebrovascular Circulation; Coma; Humans; Hy

1987
Traumatic brain injury in the rat: alterations in brain lactate and pH as characterized by 1H and 31P nuclear magnetic resonance.
    Journal of neurochemistry, 1987, Volume: 49, Issue:5

    Topics: Animals; Brain; Brain Injuries; Cerebral Hemorrhage; Hemodynamics; Hydrogen-Ion Concentration; Intra

1987
[Lactate concentration in the ventricular fluid and blood plasma following severe craniocerebral trauma].
    Zentralblatt fur Neurochirurgie, 1985, Volume: 46, Issue:2

    Topics: Adult; Brain Injuries; Brain Ischemia; Coma; Female; Humans; Hypoxia, Brain; Intracranial Pressure;

1985
[Multiple injury and severe multiple injury (remarks on definition and pathophysiology].
    Zeitschrift fur arztliche Fortbildung, 1985, Volume: 79, Issue:22

    Topics: Abdominal Injuries; Adolescent; Adult; Aged; Blood Coagulation Factors; Brain Injuries; Child; Child

1985