lactic acid and Acidosis studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Acidosis: A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.

Research Excerpts

Excerpt	Relevance	Reference
"Studies in healthy patients undergoing elective caesarean delivery show that, compared with phenylephrine, ephedrine used to treat spinal hypotension is associated with increased fetal acidosis."	9.27	A randomised comparison of bolus phenylephrine and ephedrine for the management of spinal hypotension in patients with severe preeclampsia and fetal compromise. ( Adams, SC; Arcache, MJ; Dyer, RA; Emmanuel, A; Higgins, N; James, MF; Joolay, Y; Lombard, CJ; Reed, AR; Schulein, S; van Dyk, D; Vorster, A; Wong, CA, 2018)
"The combination of propylene glycol ingestion and alcoholic ketoacidosis may have contributed to the severity of lactic acidosis."	8.12	Unexplained Metabolic Acidosis: Alcoholic Ketoacidosis or Propylene Glycol Toxicity. ( Boland, L; de Landsheere, F; Dewulf, JP; Dulaurent, S; Hantson, P; Haufroid, V; Laterre, PF; Saint-Marcoux, F, 2022)
"Background Lactic acidosis is associated with mortality in patients with cardiogenic shock (CS)."	8.12	Association Between the Acidemia, Lactic Acidosis, and Shock Severity With Outcomes in Patients With Cardiogenic Shock. ( Barsness, GW; Blankenberg, S; Holmes, DR; Jentzer, JC; Kashani, KB; Kirchhof, P; Patel, PC; Schrage, B; Westermann, D, 2022)
"D-lactic acidosis represents a rare form of metabolic acidosis that occurs most commonly in patients with short bowel syndrome."	8.02	D-lactic acidosis - a rare complication of short bowel syndrome. ( Majdák, P; Morgošová, S; Podušel, V; Sadloňová, J, 2021)
" Initial severe acidosis consisted of acute respiratory acidosis from ventilation-perfusion mismatch and acute metabolic acidosis resulting from bronchospasm and hypoxia-related lactic acidosis, respectively."	8.02	Salbutamol-induced lactic acidosis in status asthmaticus survivor. ( Boonkaya, S; Phoophiboon, V; Singhagowinta, P; Sriprasart, T, 2021)
" We describe a rare case of multiple organ failure due to intravascular lymphoma with severe lactic acidosis in a patient who survived."	7.96	Successful Intensive Care Treatment of Severe Lactic Acidosis and Tumor Lysis Syndrome Related to Intravascular Lymphoma. ( Genda, Y; Ichiba, S; Mase, H; Ogawa, Y; Sakamoto, A; Takeuchi, J, 2020)
"Gap acidosis except lactic acidosis developed and progressed during the CKD stage G5, while lactic acidosis developed in the CKD stages G1-4."	7.91	Gap acidosis except lactic acidosis develops and progresses during chronic kidney disease stage G5. ( Tanemoto, M, 2019)
" We propose the research and development of therapeutic approaches for preemptive, short- and long-term management of cancer pain using available drugs or nutraceutical agents that can suppress or neutralize lactic acid production in combination with formaldehyde scavengers."	7.81	Acidosis and Formaldehyde Secretion as a Possible Pathway of Cancer Pain and Options for Improved Cancer Pain Control. ( Fang, JY; Han, B; Hoang, BX; Nimni, M; Shaw, DG, 2015)
" elsdenii H6F32) on ruminal pH and the lactic acid concentrations in simulated rumen acidosis conditions in vitro."	7.80	Effects of the acid-tolerant engineered bacterial strain Megasphaera elsdenii H6F32 on ruminal pH and the lactic acid concentration of simulated rumen acidosis in vitro. ( Feng, WJ; He, JB; He, RX; Jing, WY; Li, P; Li, YM; Liu, GW; Long, M; Wang, Z; Yu, LH; Zhang, Y, 2014)
" Our purposes were to study the efficacy of tranexamic acid (TXA) and prothrombin complex concentrate (PCC) on a traumatic coagulopathy with a severe native metabolic acidosis and compare the efficacy of PCC versus fresh frozen plasma (FFP) to reverse a dilutional coagulopathy."	7.79	The effects of tranexamic acid and prothrombin complex concentrate on the coagulopathy of trauma: an in vitro analysis of the impact of severe acidosis. ( Eckert, M; Izenberg, S; Martin, MJ; McVay, D; Nelson, D; Porta, CR; Salgar, S, 2013)
" The aim of the present study was to examine the impact of a novel NHE1 inhibitor, sabiporide, on cardiovascular function, blood oxygen transportation, and inflammatory response in an experimental model of metabolic acidosis produced by hemorrhage-induced hypovolemia followed by an infusion of lactic acid."	7.79	Sabiporide improves cardiovascular function, decreases the inflammatory response and reduces mortality in acute metabolic acidosis in pigs. ( Abraham, WM; Kraut, JA; Wu, D, 2013)
"The effects of grain, fructose, and histidine on ruminal pH and fermentation products were studied in dairy cattle during an induced subacute acidosis protocol."	7.78	Effects of grain, fructose, and histidine on ruminal pH and fermentation products during an induced subacute acidosis protocol. ( Bramley, E; Celi, P; Golder, HM; Heuer, C; King, R; Lean, IJ; Miller, DW; Rabiee, AR, 2012)
" Two important determinants in this environment are hypoxia and lactic acidosis."	7.74	The genomic analysis of lactic acidosis and acidosis response in human cancers. ( Chen, JL; Chi, JT; Dewhirst, M; Lucas, JE; Mori, S; Nevins, J; Schroeder, T; West, M; Wu, J, 2008)
"Compared with dobutamine, levosimendan increased intestinal blood flow and diminished intramucosal acidosis in this experimental model of sepsis."	7.74	Effects of levosimendan and dobutamine in experimental acute endotoxemia: a preliminary controlled study. ( Barán, M; Canales, HS; Dubin, A; Edul, VS; Estenssoro, E; Etcheverry, G; Maskin, B; Murias, G; Pozo, MO; Sottile, JP, 2007)
"Propofol-induced metabolic acidosis is well recognised in the paediatric literature, but the existence of such a syndrome in adults remains contentious."	7.73	Short-term low-dose propofol anaesthesia associated with severe metabolic acidosis. ( Chukwuemeka, A; Ko, R; Ralph-Edwards, A, 2006)
" We have studied the components of the metabolic acidosis that accompanies urethane anaesthesia in rats, both with and without the hypothermia that results from this anaesthesia."	7.69	Components of the blood acid-base disturbance that accompanies urethane anaesthesia in rats during normothermia and hypothermia. ( Alfaro, V; Palacios, L, 1997)
"A 71 year old hypertensive, non insulin-dependent diabetic patient with moderate renal insufficiency taking 500 mg/d of metformin and 5 mg/d of enalapril, developed metabolic acidosis characterized by fairly elevated anion gap, hyperchloremia, severe hyperkaliemia, normal plasma level of 3-hydroxybutyric acid, absence of ketonuria and high plasma level of lactic acid."	7.69	Possible synergistic effect of metformin and enalapril on the development of hyperkaliemic lactic acidosis. ( Elisabetta, Z; Emanuela, M; Franzetti, I; Marco, G; Paolo, D; Renato, U, 1997)
" We observed a patient with nonmetastatic breast cancer who died because of severe lactic acidosis (plasma lactate concentration = 27 mmol/l) after ingestion of 25 g of elemental germanium over a 2-months period."	7.68	Abuse of germanium associated with fatal lactic acidosis. ( Iten, PX; Krapf, R; Schaffner, T, 1992)
"A case of a unique combination of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like syndrome (MELAS) with acanthocytosis is reported."	7.67	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes with acanthocytosis: a clinicopathological study of a unique case. ( Kazui, H; Mukoyama, M; Nonaka, I; Satoyoshi, E; Sunohara, N; Yoshida, M, 1986)
"An enzymatic study of cultured skin fibroblasts was made in 28 patients with lactic acidosis."	7.67	Biochemical study in 28 children with lactic acidosis, in relation to Leigh's encephalomyelopathy. ( Iinuma, K; Ito, T; Miyabayashi, S; Narisawa, K; Tada, K, 1985)
"Sodium dichloroacetate (DCA) was administered orally at a dose of 50 mg per kg body weight twice or three times per day to a newborn infant with lactic acidosis of unknown cause (patient 1) and to a 15-year-old boy with mitochondrial encephalomyopathy associated with lactic acidosis (patient 2)."	7.67	Treatment of chronic congenital lactic acidosis by oral administration of dichloroacetate. ( Hashimoto, T; Hwang, TJ; Ito, M; Kuroda, Y; Masuda, M; Miyao, M; Naito, E; Takeda, E; Toshima, K; Yamashita, K, 1986)
"Hypoxic lactic acidosis (HLA) was induced in dogs by ventilating them with a hypoxic gas mixture of 8% O2-92% N2."	7.67	Pathophysiology of type A hypoxic lactic acidosis in dogs. ( Arieff, AI; Graf, H, 1987)
"We report on a patient, now 17 year old, in whom lactic acidosis was detected at the age of 7 while attempting to diagnose the causes of increasing weakness."	7.67	[Lactic acid acidosis with mitochondrial myopathy due to a pyruvate dehydrogenase deficiency]. ( Dworschak, E; Hammerer, I; Höpfel, I; Maurer, H; Sperl, W, 1985)
"1) in leukocytes and muscle tissue from a 10-year old child with persistent lactic acidosis, suffering from myasthenia and growth retardation."	7.67	[Pyruvate dehydrogenase deficiency in a child with persistent lactic acidosis]. ( Berger, H; Dworzak, E; Grunicke, H; Haas, H; Höpfel, I; Jarosch, E, 1985)
"It appears that glutamine and lactate are the principal substrates for the kidney in dogs with chronic metabolic acidosis."	7.67	Effect of the blood lactate concentration on renal glutamine metabolism in dogs with chronic metabolic acidosis. ( Cheema-Dhadli, S; Chen, CB; Halperin, ML, 1985)
"The mechanism(s) for the hyperphosphatemia associated with lactic acidosis is unknown."	7.67	Pathogenesis of hyperphosphatemia in lactic acidosis: disparate effects of racemic (DL-) and levo (L-) lactic acid on plasma phosphorus concentration. ( Alpert, HC; Oster, JR; Vaamonde, CA, 1985)
"Lactic acidosis is a clinical condition due to accumulation of H(+) ions from lactic acid, characterized by blood lactate levels >5 mM and arterial pH <7."	7.66	Treatment of lactic acidosis with dichloroacetate in dogs. ( Arieff, AI; Park, R, 1982)
"Two patients with biotin-responsive multiple carboxylase deficiency, both presenting with predominant lactic acidosis, are reported."	7.66	Lactic acidosis in biotin-responsive multiple carboxylase deficiency caused by holocarboxylase synthetase deficiency of early and late onset. ( Brewster, T; Gravel, RA; Robinson, BH; Saunders, M; Sherwood, WG, 1982)
"Pyruvate dehydrogenase complex (PDHC) activity was measured in cultured fibroblasts from 12 patients with Friedreich's ataxia (FA), and in 1 patient with lactic acidosis and ataxia."	7.66	Pyruvate-dehydrogenase complex in ataxic patients: enzyme deficiency in ataxic encephalopathy plus lactic acidosis and normal activity in Friedreich ataxia. ( Bottacchi, E; Cardace, G; Di Donato, S; Giovanardi-Rossi, P; Moschen, G; Uziel, G, 1982)
"We administered dichloroacetate, which prevents or reverses hyperlactatemia in animals and lowers plasma lactate levels in human beings, to 13 patients with lactic acidosis of various causes."	7.66	Treatment of lactic acidosis with dichloroacetate. ( Baumgartner, TG; Curry, SH; Harman, EM; Misbin, RI; Stacpoole, PW, 1983)
" During the challenge, the morning feeding was replaced by an intraruminal supply of wheat (readily fermentable starch), corn (slowly fermentable starch), or beet pulp (easily digestible fiber), dosed at 1."	6.75	Experimental feed induction of ruminal lactic, propionic, or butyric acidosis in sheep. ( Berger, C; Lettat, A; Martin, C; Morgavi, DP; Nozière, P; Silberberg, M, 2010)
"Extracellular acidosis is considered as a hallmark of most human tumors, which plays an important role in promoting tumor malignant and aggressive phenotype in tumorigenesis."	5.56	Differential metabolic responses in breast cancer cell lines to acidosis and lactic acidosis revealed by stable isotope assisted metabolomics. ( Cheng, J; Dong, F; Gao, J; Guo, Z; Li, H; Sun, B; Wu, S; Yan, X; Yang, J, 2020)
"Metabolic acidosis is one of the many metabolic derangements triggered by severe trauma/hemorrhagic shock, also including enhanced proteolysis, lipid mobilization, as well as traumatic diabetes."	5.43	Plasma First Resuscitation Reduces Lactate Acidosis, Enhances Redox Homeostasis, Amino Acid and Purine Catabolism in a Rat Model of Profound Hemorrhagic Shock. ( Banerjee, A; Chapman, MP; D'Alessandro, A; Fragoso, M; Gonzalez, E; Hansen, KC; Moore, EE; Moore, HB; Morton, AP; Nemkov, T; Sauaia, A; Silliman, CC; Slaughter, A; Wither, MJ, 2016)
"Studies in healthy patients undergoing elective caesarean delivery show that, compared with phenylephrine, ephedrine used to treat spinal hypotension is associated with increased fetal acidosis."	5.27	A randomised comparison of bolus phenylephrine and ephedrine for the management of spinal hypotension in patients with severe preeclampsia and fetal compromise. ( Adams, SC; Arcache, MJ; Dyer, RA; Emmanuel, A; Higgins, N; James, MF; Joolay, Y; Lombard, CJ; Reed, AR; Schulein, S; van Dyk, D; Vorster, A; Wong, CA, 2018)
"Hyperglycemia was found consistently within 12 hours after injury (224 +/- 98 mg/dl, P less than 0."	5.27	Hyperglycemia, cerebrospinal fluid lactic acidosis, and cerebral blood flow in severely head-injured patients. ( De Salles, AA; Muizelaar, JP; Young, HF, 1987)
"The hyperproteinemia was attributed to dehydration, the lactic acidemia to shock, and the hyperphosphatemia to acidosis and transient renal failure."	5.27	The acidosis of cholera. Contributions of hyperproteinemia, lactic acidemia, and hyperphosphatemia to an increased serum anion gap. ( Butler, T; Jones, PK; Rabbani, GH; Wang, F, 1986)
"In 31 cases of proved viral meningitis as with 58 cases of clinically diagnosed viral meningitis, levels were below 3."	5.26	Cerebrospinal fluid lactic acidosis in bacterial meningitis. ( Dorman, D; Eross, J; Silink, M, 1981)
"3 g·kg of sodium bicarbonate (NaHCO3, alkalosis), or 0."	5.24	Acidosis, but Not Alkalosis, Affects Anaerobic Metabolism and Performance in a 4-km Time Trial. ( Bertuzzi, R; Bishop, DJ; Correia-Oliveira, CR; Kiss, MAPD; Lima-Silva, AE; Lopes-Silva, JP; McConell, GK, 2017)
"Acute acidosis was induced in sheep, and gastrointestinal permeability was assessed by using lactulose as a permeability marker."	5.19	Experimental acute rumen acidosis in sheep: consequences on clinical, rumen, and gastrointestinal permeability conditions and blood chemistry. ( Ahmed, S; Bani, P; Bertoni, G; Jahan, N; Minuti, A; Piccioli-Cappelli, F; Trevisi, E, 2014)
" The postoperative incidence and severity of lactic acidosis were higher in the placebo group."	5.08	Evaluation of oxygen availability with oxygen status algorithm in patients undergoing open heart surgery treated with epoetin beta. ( Franke, W; Glatzel, E; Gross, J; Lun, A; Messinger, D; Scigalla, P; Sowade, B; Sowade, O; Warnke, H, 1997)
"5 mmol/l) lead to hyperlactatemia in all patients without signs of overt lactic acidosis but showed a better control of acid-base balance (pH, base excess, standard bicarbonate) than the type I bicarbonate-buffered fluid (p < 0."	5.07	Which bicarbonate concentration is adequate to lactate-buffered substitution fluids in maintenance hemofiltration? ( Böhm, R; Clasen, W; Gladziwa, U; Mann, H; Riehl, J; Sieberth, HG, 1994)
"10 at each work load); 2) hyperventilation following acetazolamide (which returned pH to control values despite ventilation and PaCO2 identical to condition 1); and 3) metabolic acidosis induced by acetazolamide (with spontaneous ventilation)."	5.06	Effect of respiratory alkalosis during exercise on blood lactate. ( Davies, SF; Iber, C; Keene, SA; McArthur, CD; Path, MJ, 1986)
" The primary outcomes were mortality, occurrence of lactic acidosis and myocardial infarction (MI) in patients taking metformin during dialysis treatment for ≥12 months (long term)."	5.01	Is the use of metformin in patients undergoing dialysis hazardous for life? A systematic review of the safety of metformin in patients undergoing dialysis. ( Abdel Shaheed, C; Carland, JE; Chowdhury, G; Day, RO; Furlong, T; Graham, GG; Greenfield, JR; Hicks, M; Macdonald, P; Smith, FC; Smith, G; Stocker, SL; Williams, KM, 2019)
"Three important issues concerning homeostasis in the acute care of trauma patients that are related directly to the stress response are hyperglycemia, lactic acidosis, and hypothermia."	4.84	Trauma and aggressive homeostasis management. ( Baranov, D; Neligan, P, 2007)
"The development of acidosis during intense exercise has traditionally been explained by the increased production of lactic acid, causing the release of a proton and the formation of the acid salt sodium lactate."	4.82	Biochemistry of exercise-induced metabolic acidosis. ( Ghiasvand, F; Parker, D; Robergs, RA, 2004)
" Then, the clinical interpretation of lactate measurements includes sections on the causes and treatments of hemodynamic deficits leading to lactic acidosis, the classification of lactate abnormalities, and the use of lactate measurements in critical care monitoring, including surgery."	4.78	Blood lactate: biochemistry, laboratory methods, and clinical interpretation. ( Toffaletti, JG, 1991)
"Although the term anaerobic threshold was introduced 20 years ago, the concept that an exercise-induced lactic acidosis occurs at a particular oxygen uptake which varies among subjects is over 50 years old."	4.77	Anaerobic threshold: review of the concept and directions for future research. ( Davis, JA, 1985)
"The combination of propylene glycol ingestion and alcoholic ketoacidosis may have contributed to the severity of lactic acidosis."	4.12	Unexplained Metabolic Acidosis: Alcoholic Ketoacidosis or Propylene Glycol Toxicity. ( Boland, L; de Landsheere, F; Dewulf, JP; Dulaurent, S; Hantson, P; Haufroid, V; Laterre, PF; Saint-Marcoux, F, 2022)
"Background Lactic acidosis is associated with mortality in patients with cardiogenic shock (CS)."	4.12	Association Between the Acidemia, Lactic Acidosis, and Shock Severity With Outcomes in Patients With Cardiogenic Shock. ( Barsness, GW; Blankenberg, S; Holmes, DR; Jentzer, JC; Kashani, KB; Kirchhof, P; Patel, PC; Schrage, B; Westermann, D, 2022)
"D-lactic acidosis represents a rare form of metabolic acidosis that occurs most commonly in patients with short bowel syndrome."	4.02	D-lactic acidosis - a rare complication of short bowel syndrome. ( Majdák, P; Morgošová, S; Podušel, V; Sadloňová, J, 2021)
" Initial severe acidosis consisted of acute respiratory acidosis from ventilation-perfusion mismatch and acute metabolic acidosis resulting from bronchospasm and hypoxia-related lactic acidosis, respectively."	4.02	Salbutamol-induced lactic acidosis in status asthmaticus survivor. ( Boonkaya, S; Phoophiboon, V; Singhagowinta, P; Sriprasart, T, 2021)
" Records were reviewed to identify cases coded as "methanol" or "ethylene glycol"; or coded as "alcohol" or "ethanol with acidosis."	4.02	Distinguishing between toxic alcohol ingestion vs alcoholic ketoacidosis: how can we tell the difference? ( Biary, R; Cohen, ET; Hoffman, RS; Su, MK, 2021)
"D-lactic acidosis is an uncommon cause of high anion gap acidosis."	3.96	High anion gap metabolic acidosis caused by D-lactate: mind the time of blood collection. ( Hiele, M; Vermeersch, P; Weemaes, M, 2020)
" The patient showed severe intraoperative hypotension, lactic acidosis, and complete abolition of motor-evoked potentials during the positioning of posterior corrective bars."	3.96	Liver and skeletal muscle injury in a 12-year-old female patient after scoliosis correction in prone position: a case report. ( Bacchin, R; Feoli, A; Ghisi, D; Greggi, T; Morigi, A, 2020)
" Organic acids in urine analysis, in addition to the clinical context, suggested a diagnosis of D-lactic acidosis."	3.96	[An acidosis not so basic]. ( Benoist, JF; Ecochard-Dugelay, E; Hugot, JP; Imbard, A; Lefrère, B; Mosca, A, 2020)
" We describe a rare case of multiple organ failure due to intravascular lymphoma with severe lactic acidosis in a patient who survived."	3.96	Successful Intensive Care Treatment of Severe Lactic Acidosis and Tumor Lysis Syndrome Related to Intravascular Lymphoma. ( Genda, Y; Ichiba, S; Mase, H; Ogawa, Y; Sakamoto, A; Takeuchi, J, 2020)
"Amino acid derangements are common in severe falciparum malaria and have been associated with endothelial dysfunction (L-arginine), metabolic acidosis (alanine and lactate), and disease severity (phenylalanine and tryptophan metabolites)."	3.91	Amino acid derangements in adults with severe falciparum malaria. ( Apinan, S; Barua, A; Day, NPJ; Dondorp, AM; Dutta, AK; Ghose, A; Hossain, A; Kingston, HW; Leopold, SJ; Paul, S; Plewes, KA; Sattar, A; Tarning, J; White, NJ; Winterberg, M, 2019)
"Gap acidosis except lactic acidosis developed and progressed during the CKD stage G5, while lactic acidosis developed in the CKD stages G1-4."	3.91	Gap acidosis except lactic acidosis develops and progresses during chronic kidney disease stage G5. ( Tanemoto, M, 2019)
"Frequent causes of high anion gap metabolic acidosis (HAGMA) are lactic acidosis, ketoacidosis and impaired renal function."	3.88	High anion gap metabolic acidosis induced by cumulation of ketones, L- and D-lactate, 5-oxoproline and acute renal failure. ( Heireman, L; Helbert, M; Mahieu, B; Piqueur, M; Stroobants, J; Uyttenbroeck, W, 2018)
"The presence and magnitude of hyperlactatemia on presentation to the emergency room may help identify dogs and cats with high likelihood of in-hospital mortality, and the presence of lactic acidosis specifically may help identify dogs with yet higher risk of in-hospital mortality."	3.88	Retrospective evaluation of the prognostic utility of plasma lactate concentration, base deficit, pH, and anion gap in canine and feline emergency patients. ( Epstein, SE; Hopper, K; Kass, PH; Kohen, CJ, 2018)
"Ethylene glycol toxicity is a known cause of anion gap metabolic acidosis, with the presence of an osmolar gap and the right clinical context suggesting to the diagnosis."	3.88	Lactate gap as a tool in identifying ethylene glycol poisoning. ( Jimenez, CA; Mckelvy, BJ; Sagar, AS, 2018)
"The effect of lactic acidosis on neurological development in the first year of life."	3.88	Neurological impairments in hypoxic neonates and lactate levels. ( Jovandaric, MZ; Milenkovic, SJ, 2018)
" It appears that alkaline water can be an effective alternative to sodium bicarbonate in preventing the effects of exercise-induced metabolic acidosis."	3.88	Alkaline water improves exercise-induced metabolic acidosis and enhances anaerobic exercise performance in combat sport athletes. ( Chycki, J; Golas, A; Kurylas, A; Maszczyk, A; Zajac, A, 2018)
" He was found to have high anion gap metabolic acidosis with significantly elevated lactate along with an elevated osmolal gap and calcium oxalate crystals in his urine."	3.85	Two gaps too many, three clues too few? Do elevated osmolal and anion gaps with crystalluria always mean ethylene glycol poisoning? ( Abu Sitta, E; Gaddam, M; Kanzy, A; Velagapudi, RK, 2017)
" We propose the research and development of therapeutic approaches for preemptive, short- and long-term management of cancer pain using available drugs or nutraceutical agents that can suppress or neutralize lactic acid production in combination with formaldehyde scavengers."	3.81	Acidosis and Formaldehyde Secretion as a Possible Pathway of Cancer Pain and Options for Improved Cancer Pain Control. ( Fang, JY; Han, B; Hoang, BX; Nimni, M; Shaw, DG, 2015)
" elsdenii H6F32) on ruminal pH and the lactic acid concentrations in simulated rumen acidosis conditions in vitro."	3.80	Effects of the acid-tolerant engineered bacterial strain Megasphaera elsdenii H6F32 on ruminal pH and the lactic acid concentration of simulated rumen acidosis in vitro. ( Feng, WJ; He, JB; He, RX; Jing, WY; Li, P; Li, YM; Liu, GW; Long, M; Wang, Z; Yu, LH; Zhang, Y, 2014)
"In 70 mechanically-ventilated patients with septic shock, we examined: a) S' and E' mitral annular velocities using tissue Doppler imaging (TDI), b) CFR of the left anterior descending artery after adenosine infusion using transesophageal Doppler echocardiography and c) lactate, pyruvate and glycerol in tissue by means of a microdialysis (MD) catheter inserted into the subcutaneous adipose tissue as markers of tissue ischemia and acidosis."	3.80	Coronary flow reserve is associated with tissue ischemia and is an additive predictor of intensive care unit mortality to traditional risk scores in septic shock. ( Armaganidis, A; Diamantakis, A; Dimopoulou, I; Ikonomidis, I; Kopterides, P; Lekakis, J; Makavos, G; Nikitas, N; Paraskevaidis, I; Parissis, J; Theodorakopoulou, M, 2014)
" The aim of this study was to clarify the association between lactic acidosis and NPE in patients with nontraumatic SAH."	3.80	Association between serum lactate levels and early neurogenic pulmonary edema after nontraumatic subarachnoid hemorrhage. ( Fuse, A; Gemma, A; Matsumoto, G; Onda, H; Satoh, E; Suzuki, G; Tagami, T; Watanabe, A; Yokota, H, 2014)
"Flutamide failed to show any benefit to resuscitation in a model of severe injury and was associated with increased acidosis, hemodilution, and liver injury compared with standard crystalloid resuscitation."	3.79	Flutamide fails to reduce resuscitation requirements in a porcine ischemia-reperfusion model. ( Hempel, J; Hoffer, Z; Martin, M; Satterly, SA; Stallings, JD; Wingerd, M, 2013)
" Our purposes were to study the efficacy of tranexamic acid (TXA) and prothrombin complex concentrate (PCC) on a traumatic coagulopathy with a severe native metabolic acidosis and compare the efficacy of PCC versus fresh frozen plasma (FFP) to reverse a dilutional coagulopathy."	3.79	The effects of tranexamic acid and prothrombin complex concentrate on the coagulopathy of trauma: an in vitro analysis of the impact of severe acidosis. ( Eckert, M; Izenberg, S; Martin, MJ; McVay, D; Nelson, D; Porta, CR; Salgar, S, 2013)
" Metabolic acidosis was defined by base excess (BE) <-2 mmol/L and, wherever applicable, subdivided into lactic acidosis by lactate >50% of BE, anion gap (AG)-acidosis by AG >16 mmol/L, hyperchloraemic acidosis by chloride >115 mmol/L."	3.79	Point-of-care testing on admission to the intensive care unit: lactate and glucose independently predict mortality. ( Blobner, M; Busch, R; Kochs, E; Luppa, PB; Martin, J; Moser, N, 2013)
" The aim of the present study was to examine the impact of a novel NHE1 inhibitor, sabiporide, on cardiovascular function, blood oxygen transportation, and inflammatory response in an experimental model of metabolic acidosis produced by hemorrhage-induced hypovolemia followed by an infusion of lactic acid."	3.79	Sabiporide improves cardiovascular function, decreases the inflammatory response and reduces mortality in acute metabolic acidosis in pigs. ( Abraham, WM; Kraut, JA; Wu, D, 2013)
"The effects of grain, fructose, and histidine on ruminal pH and fermentation products were studied in dairy cattle during an induced subacute acidosis protocol."	3.78	Effects of grain, fructose, and histidine on ruminal pH and fermentation products during an induced subacute acidosis protocol. ( Bramley, E; Celi, P; Golder, HM; Heuer, C; King, R; Lean, IJ; Miller, DW; Rabiee, AR, 2012)
"The effectiveness of sodium bicarbonate (SB) has recently been questioned although it is often used to correct metabolic acidosis of neonates."	3.78	Infusing sodium bicarbonate suppresses hydrogen peroxide accumulation and superoxide dismutase activity in hypoxic-reoxygenated newborn piglets. ( Bigam, DL; Cheung, PY; Lee, TF; Liu, JQ; Manouchehri, N; Yao, M, 2012)
" Calves that stand insecurely and are not able to correct their position if pushed require higher doses of sodium bicarbonate, if there is clinical evidence of a marked D-lactic acidosis."	3.78	Construction and validation of a decision tree for treating metabolic acidosis in calves with neonatal diarrhea. ( Feist, M; Lorch, A; Lorenz, I; Sauter-Louis, C; Trefz, FM, 2012)
"Because previous researchers have reported a reduced lactic acid production that accompanies a delayed or an absent ventilatory threshold (VTh) in water-based exercise, we hypothesized that the metaboreflex, activated by muscle acidosis, might be absent in fin swimming."	3.76	EMG changes in thigh and calf muscles in fin swimming exercise. ( Bregeon, F; Brerro-Saby, C; Coulange, M; Delliaux, S; Jammes, C; Jammes, Y; Kipson, N, 2010)
"The cause-effect relationship between lactic acid, acidosis, and muscle fatigue has been established in the literature."	3.75	Is lactate production related to muscular fatigue? A pedagogical proposition using empirical facts. ( Catanho da Silva, FO; Hohl, R; Lazarim, FL; Macedo, DV; Tessuti, LS, 2009)
"Recovery of endothelial function in severe malaria is associated with recovery from hypoargininemia and lactic acidosis."	3.74	Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations. ( Anstey, NM; Celermajer, DS; Darcy, CJ; Duffull, SB; Gitawati, R; Granger, DL; Kenangalem, E; Lampah, DA; Lopansri, BK; McNeil, YR; Price, RN; Tjitra, E; Weinberg, JB; Yeo, TW, 2008)
" Two important determinants in this environment are hypoxia and lactic acidosis."	3.74	The genomic analysis of lactic acidosis and acidosis response in human cancers. ( Chen, JL; Chi, JT; Dewhirst, M; Lucas, JE; Mori, S; Nevins, J; Schroeder, T; West, M; Wu, J, 2008)
"It has been concluded from comparisons of base excess (BE) and lactic acid (La) concentration changes in blood during exercise-induced acidosis that more H+ than La- leave the muscle and enter interstitial fluid and blood."	3.74	Causes of differences in exercise-induced changes of base excess and blood lactate. ( Böning, D; Himmelsbach, B; Hütler, M; Klarholz, C; Maassen, N, 2007)
"Compared with dobutamine, levosimendan increased intestinal blood flow and diminished intramucosal acidosis in this experimental model of sepsis."	3.74	Effects of levosimendan and dobutamine in experimental acute endotoxemia: a preliminary controlled study. ( Barán, M; Canales, HS; Dubin, A; Edul, VS; Estenssoro, E; Etcheverry, G; Maskin, B; Murias, G; Pozo, MO; Sottile, JP, 2007)
" One possible mechanism of brain edema is glial swelling due to lactic acidosis associated with ischemia."	3.74	Lactic acid increases aquaporin 4 expression on the cell membrane of cultured rat astrocytes. ( Aoyama, M; Arima, H; Asai, K; Fujita, Y; Hirate, H; Iida, Y; Katsuya, H; Morishima, T; Sasano, H; Sobue, K; Tsuda, T; Yamamoto, N, 2008)
" Biochemically, beta-ketothiolase deficiency is characterized by intermittent ketoacidosis and urinary excretion of 2-methyl-acetoacetate (MAA), 2-methyl-3-hydroxybutyrate (MHB) and tiglylglycine (TG), whereas in MHBD deficiency only MHB and tiglylglycine accumulate."	3.73	Inhibition of energy metabolism by 2-methylacetoacetate and 2-methyl-3-hydroxybutyrate in cerebral cortex of developing rats. ( da C Ferreira, G; Dalcin, KB; de Assis, DR; Filho, CS; Latini, A; Leipnitz, G; Maria, RC; Perry, ML; Ribeiro, CA; Rosa, RB; Schuck, PF; Wajner, M; Wannmacher, CM; Wyse, AT, 2005)
" His blood gas analysis showed a metabolic acidosis caused by renal failure and lactic acidosis combined with a hypochloraemic alkalosis."	3.73	[A mixed acid-base disorder revealing a cystic dystrophy of aberrant pancreatic tissue]. ( Bedock, B; Dumaine, A; Gauclère, V; Legrand, E; Proust, P; Rozière, A; Tayssir, A, 2006)
"Levosimendan improved oxygen transport and prevented the development of intramucosal acidosis in this experimental model of endotoxaemia."	3.73	Effects of levosimendan in normodynamic endotoxaemia: a controlled experimental study. ( Barán, M; Canales, HS; Dubin, A; Edul, VS; Estenssoro, E; Maskin, B; Murias, G; Pozo, MO; Sottile, JP, 2006)
" Critically ill patients were selected on the clinical suspicion of the presence of lactic acidosis."	3.73	Lactate versus non-lactate metabolic acidosis: a retrospective outcome evaluation of critically ill patients. ( Gunnerson, KJ; He, S; Kellum, JA; Saul, M, 2006)
" The authors present the cases of two children who developed relatively uncommon adverse effects to new anticonvulsant medications, including metabolic acidosis with topiramate and hyponatremia with oxcarbazepine."	3.73	New anticonvulsants--new adverse effects. ( Tebb, Z; Tobias, JD, 2006)
" This effect disappeared, however, when hypoxia was combined with acidosis obtained by 24 mM lactic acid."	3.73	Force development at elevated [Mg2+]o and [K+]o in myocardium from the freshwater turtle (Trachemys scripta) and influence of factors associated with hibernation. ( Gesser, H, 2006)
"Propofol-induced metabolic acidosis is well recognised in the paediatric literature, but the existence of such a syndrome in adults remains contentious."	3.73	Short-term low-dose propofol anaesthesia associated with severe metabolic acidosis. ( Chukwuemeka, A; Ko, R; Ralph-Edwards, A, 2006)
"Lactic acidosis and increased production of CO(2) are common in septic shock."	3.72	Increased tissue oxygen extraction and acidosis with progressive severity of sepsis. ( Chinkes, DL; Gore, DC; Hart, DW, 2003)
" The principal findings included metabolic acidosis accompanied by an increase in the plasma anion gap that was not caused by L -lactic acidosis, hyperkalemia, and the abrupt onset of hypotension."	3.71	Citric acid ingestion: a life-threatening cause of metabolic acidosis. ( DeMars, CS; Halperin, ML; Himmelfarb, J; Hollister, K; Tomassoni, A, 2001)
"We tested the hypothesis that the respiratory function of skeletal muscle mitochondria is impaired by lactic acidosis and elevated concentrations of P(i)."	3.71	Increased concentrations of P(i) and lactic acid reduce creatine-stimulated respiration in muscle fibers. ( Sahlin, K; Tiivel, T; Tonkonogi, M; Walsh, B, 2002)
" A variety of conditions preceded the onset of acidosis, and all had taken acetaminophen (paracetamol), although in therapeutic amounts in most subjects."	3.70	Transient 5-oxoprolinuria and high anion gap metabolic acidosis: clinical and biochemical findings in eleven subjects. ( Hauser, S; Pitt, JJ, 1998)
" Ingestion of ammonium chloride developed a state of metabolic acidosis."	3.70	Pre-exercise acidification induced by ingestion of NH4Cl increases the magnitude of the slow component of VO2 kinetics in humans. ( Domański, J; Duda, K; Emmerich, J; Majerczak, J; Zoładź, J, 1998)
" The effects of diltiazem, verapamil, and nifedipine on extracellular potassium concentration ([K+]e), acidosis, and level of metabolic markers were examined during 30-min global ischemia and postischemic left ventricular (LV) function in isolated guinea pig hearts."	3.70	Temporal differences in actions of calcium channel blockers on K+ accumulation, cardiac function, and high-energy phosphate levels in ischemic guinea pig hearts. ( Nagao, T; Sato, R; Yamazaki, J, 1999)
"The intraoperative development of metabolic acidosis is frequently attributed to hypovolemia, tissue hypoperfusion, and lactic acidosis."	3.70	Cause of metabolic acidosis in prolonged surgery. ( Clack, S; Kim, JV; Miller, LR; Waters, JH, 1999)
"In children with small short bowel and acidosis, the common intestinal flora of mainly lactobacilli abundantly produces D-lactic acid from easily fermentable carbohydrates."	3.70	Lactobacilli and acidosis in children with short small bowel. ( Bakkeren, J; Bongaerts, G; Naber, T; Severijnen, R; Sperl, W; Tolboom, J; van Meurs, A; Wevers, R; Willems, H, 2000)
"To study effects of acidosis on glucagon secretion and gluconeogenetic action of glucagon, rat pancreas and liver were perfused with media of pH 6."	3.70	Acidotic pH augments glucagon secretion and gluconeogenesis in the isolated perfused rat pancreas and liver. ( Mokuda, O; Sakamoto, Y, 2000)
"The aim was to examine the effects of the Na+/H+ exchange inhibitor methylisobutylamiloride (MIA) as well as protein kinase C, a putative regulator of Na+/H+ exchange, on intracellular calcium, intracellular pH, and unloaded cell shortening in isolated guinea pig cardiac myocytes subjected to lactic acid induced acidosis followed by realkalinisation."	3.69	Modulation of sodium-hydrogen exchange activity in cardiac myocytes during acidosis and realkalinisation: effects on calcium, pHi, and cell shortening. ( Moffat, MP; Ward, CA, 1995)
"Pyruvate transport and carboxylation have been determined in mitochondria from liver and kidney cortex isolated from Wistar rats with acidosis produced by three different treatments: fasting, exercise and ingestion of ammonium chloride."	3.69	Mitochondrial pyruvate metabolism in liver and kidney during acidosis. ( Oliver, FJ; Salto, R; Sola, MM; Vargas, AM, 1994)
"This study examines the neonatal response to graded hypoxia and determines the arterial PO2 (PaO2) threshold for oxygen-restricted metabolism as confirmed by the development of lactic acidosis and altered oxygen handling."	3.69	Blood lactate and acid-base balance in graded neonatal hypoxia: evidence for oxygen-restricted metabolism. ( Torrance, SM; Wittnich, C, 1994)
" After propranolol, CaCl2 was given during acidosis and hyperkalemia."	3.69	Role of Ca2+ in protecting the heart from hyperkalemia and acidosis in the rabbit: implications for exercise. ( Leitch, SP; Paterson, DJ, 1994)
" IDDM children exhibited pronounced lactic acidosis under stress (pH: group 2, 7."	3.69	Sympathetic-adrenergic activity and acid-base regulation under acute physical stress in type I (insulin-dependent) diabetic children. ( Körner, A; Madácsy, L; Miltényi, M; Nagy, I; Szabó, A; Szücs, L; Tulassay, T; Yasar, SA, 1994)
" We have studied the components of the metabolic acidosis that accompanies urethane anaesthesia in rats, both with and without the hypothermia that results from this anaesthesia."	3.69	Components of the blood acid-base disturbance that accompanies urethane anaesthesia in rats during normothermia and hypothermia. ( Alfaro, V; Palacios, L, 1997)
"A 71 year old hypertensive, non insulin-dependent diabetic patient with moderate renal insufficiency taking 500 mg/d of metformin and 5 mg/d of enalapril, developed metabolic acidosis characterized by fairly elevated anion gap, hyperchloremia, severe hyperkaliemia, normal plasma level of 3-hydroxybutyric acid, absence of ketonuria and high plasma level of lactic acid."	3.69	Possible synergistic effect of metformin and enalapril on the development of hyperkaliemic lactic acidosis. ( Elisabetta, Z; Emanuela, M; Franzetti, I; Marco, G; Paolo, D; Renato, U, 1997)
" The application of cyanide (to mimic hypoxia) produced a fall of the concentration of phosphocreatine ([PCr]) and a rise of those of inorganic phosphate ([Pi]) and sugar phosphates."	3.68	Relationship between intracellular pH and metabolite concentrations during metabolic inhibition in isolated ferret heart. ( Bauer, CJ; Donoso, P; Eisner, DA; Smith, GL, 1993)
" Of the 24 fetuses with normal heart rates and abnormal velocimetry, 4 (17 percent) had moderate lactic acidosis, 1 (4 percent) had a low pH value, and 3 (12 percent) had hypoxia."	3.68	Diagnostic value of blood sampling in fetuses with growth retardation. ( Battaglia, FC; Bozzetti, P; Buscaglia, M; Cetin, I; Ferrazzi, E; Lanfranchi, A; Marconi, AM; Pardi, G, 1993)
" We observed a patient with nonmetastatic breast cancer who died because of severe lactic acidosis (plasma lactate concentration = 27 mmol/l) after ingestion of 25 g of elemental germanium over a 2-months period."	3.68	Abuse of germanium associated with fatal lactic acidosis. ( Iten, PX; Krapf, R; Schaffner, T, 1992)
" It was revealed that alterations in carbohydrate metabolism in the form of lactic acidosis and anaerobiosis developed not only because of hemodynamic and ventilatory disorders."	3.68	[Study of the changes in carbohydrate metabolism as a diagnostic test of acute hypothalamic syndrome in severe cranio-cerebral trauma]. ( Borshchagovskiĭ, ML; Krauze, VE; Kuznetsova, VM; Raĭkhinshteĭn, VE, 1990)
"These data indicate that lactic acidosis does not entirely account for the metabolic acidosis during severe sepsis."	3.68	Unaccounted for anion in metabolic acidosis during severe sepsis in humans. ( Astiz, ME; Mecher, C; Rackow, EC; Weil, MH, 1991)
" To study this problem, acute isocapnic metabolic acidosis was induced by HCl or lactic acid infusions in rats, and recovery from acidosis was accomplished by NaHCO3 infusion."	3.68	Brain pH in acute isocapnic metabolic acidosis and hypoxia: a 31P-nuclear magnetic resonance study. ( Adler, S; Ho, C; Simplaceanu, V, 1990)
" Mild hepatic energy charge deficiency and hepatic lactic acidosis were observed in sterile abscess rats, and slightly enhanced energy charge was seen in monoclonal E."	3.67	Hepatic and systemic metabolic responses to aerobic and anaerobic intra-abdominal abscesses in a highly reproducible chronic rat model. ( Hirai, F; Marzella, L; Nakatani, T; Sato, T; Siegel, JH; Trump, BF, 1984)
" Since a mixed acidosis results during a systemic toxicity reaction to bupivacaine, the influences of an acidic pH, resulting from the addition of lactic acid, also was examined."	3.67	The influence of lactic acid on the serum protein binding of bupivacaine: species differences. ( Arthur, GR; Bridenbaugh, PO; Coyle, DE; Denson, DD; Myers, JA; Thompson, GA, 1984)
"The mechanism(s) underlying the hyperphosphatemia of lactic acidosis is uncertain."	3.67	Effect of acid-base status on plasma phosphorus response to lactate. ( Alpert, HC; Oster, JR; Vaamonde, CA, 1984)
"A case of a unique combination of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like syndrome (MELAS) with acanthocytosis is reported."	3.67	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes with acanthocytosis: a clinicopathological study of a unique case. ( Kazui, H; Mukoyama, M; Nonaka, I; Satoyoshi, E; Sunohara, N; Yoshida, M, 1986)
" We suggest that activated leukocytes consume CSF glucose and produce lactic acid and secrete protons, which causes the CSF and interstitial acidosis."	3.67	Brain acidosis in experimental pneumococcal meningitis. ( Andersen, NE; Gyring, J; Hansen, AJ; Laursen, H; Siesjö, BK, 1989)
"An enzymatic study of cultured skin fibroblasts was made in 28 patients with lactic acidosis."	3.67	Biochemical study in 28 children with lactic acidosis, in relation to Leigh's encephalomyelopathy. ( Iinuma, K; Ito, T; Miyabayashi, S; Narisawa, K; Tada, K, 1985)
"Sodium dichloroacetate (DCA) was administered orally at a dose of 50 mg per kg body weight twice or three times per day to a newborn infant with lactic acidosis of unknown cause (patient 1) and to a 15-year-old boy with mitochondrial encephalomyopathy associated with lactic acidosis (patient 2)."	3.67	Treatment of chronic congenital lactic acidosis by oral administration of dichloroacetate. ( Hashimoto, T; Hwang, TJ; Ito, M; Kuroda, Y; Masuda, M; Miyao, M; Naito, E; Takeda, E; Toshima, K; Yamashita, K, 1986)
"Hypoxic lactic acidosis (HLA) was induced in dogs by ventilating them with a hypoxic gas mixture of 8% O2-92% N2."	3.67	Pathophysiology of type A hypoxic lactic acidosis in dogs. ( Arieff, AI; Graf, H, 1987)
"Ethylene glycol intoxication produces a severe metabolic acidosis with an increased anion gap."	3.67	Organic acids in ethylene glycol intoxication. ( Clay, K; Gabow, PA; Lepoff, R; Sullivan, JB, 1986)
"Metabolic acidosis was induced in 18 piglets of Swedish native breed by prolonged iv infusion of lactic acid, which decreased both blood and muscle pH."	3.67	Induction and treatment of metabolic acidosis: a study of pH changes in porcine skeletal muscle and cerebrospinal fluid. ( Sahlin, K; Wiklund, L, 1985)
"We report on a patient, now 17 year old, in whom lactic acidosis was detected at the age of 7 while attempting to diagnose the causes of increasing weakness."	3.67	[Lactic acid acidosis with mitochondrial myopathy due to a pyruvate dehydrogenase deficiency]. ( Dworschak, E; Hammerer, I; Höpfel, I; Maurer, H; Sperl, W, 1985)
"1) in leukocytes and muscle tissue from a 10-year old child with persistent lactic acidosis, suffering from myasthenia and growth retardation."	3.67	[Pyruvate dehydrogenase deficiency in a child with persistent lactic acidosis]. ( Berger, H; Dworzak, E; Grunicke, H; Haas, H; Höpfel, I; Jarosch, E, 1985)
"It appears that glutamine and lactate are the principal substrates for the kidney in dogs with chronic metabolic acidosis."	3.67	Effect of the blood lactate concentration on renal glutamine metabolism in dogs with chronic metabolic acidosis. ( Cheema-Dhadli, S; Chen, CB; Halperin, ML, 1985)
"The mechanism(s) for the hyperphosphatemia associated with lactic acidosis is unknown."	3.67	Pathogenesis of hyperphosphatemia in lactic acidosis: disparate effects of racemic (DL-) and levo (L-) lactic acid on plasma phosphorus concentration. ( Alpert, HC; Oster, JR; Vaamonde, CA, 1985)
", the highest workrate or VO2 which was achieved without evidence of lactic acidosis, as judged from the profile of ventilatory and gas exchange responses."	3.67	Effect of simulated weightlessness on exercise-induced anaerobic threshold. ( Convertino, VA; Goldwater, DJ; Karst, GM; Kirby, CR, 1986)
"Lactic acidosis is a clinical condition due to accumulation of H(+) ions from lactic acid, characterized by blood lactate levels >5 mM and arterial pH <7."	3.66	Treatment of lactic acidosis with dichloroacetate in dogs. ( Arieff, AI; Park, R, 1982)
" Eight of the 16 subjects performed a second incremental exercise test initiated during lactic acidosis."	3.66	Anaerobic threshold and lactate turnpoint. ( Bassett, J; Davis, HA; Gass, GC; Hughes, P, 1983)
"Two patients with biotin-responsive multiple carboxylase deficiency, both presenting with predominant lactic acidosis, are reported."	3.66	Lactic acidosis in biotin-responsive multiple carboxylase deficiency caused by holocarboxylase synthetase deficiency of early and late onset. ( Brewster, T; Gravel, RA; Robinson, BH; Saunders, M; Sherwood, WG, 1982)
"Pyruvate dehydrogenase complex (PDHC) activity was measured in cultured fibroblasts from 12 patients with Friedreich's ataxia (FA), and in 1 patient with lactic acidosis and ataxia."	3.66	Pyruvate-dehydrogenase complex in ataxic patients: enzyme deficiency in ataxic encephalopathy plus lactic acidosis and normal activity in Friedreich ataxia. ( Bottacchi, E; Cardace, G; Di Donato, S; Giovanardi-Rossi, P; Moschen, G; Uziel, G, 1982)
"We administered dichloroacetate, which prevents or reverses hyperlactatemia in animals and lowers plasma lactate levels in human beings, to 13 patients with lactic acidosis of various causes."	3.66	Treatment of lactic acidosis with dichloroacetate. ( Baumgartner, TG; Curry, SH; Harman, EM; Misbin, RI; Stacpoole, PW, 1983)
" These compounds were evaluated for their potential to protect ruminants against lactic acidosis."	3.66	Synthesis and evaluation of ureido- and vinylureidopenicillins as inhibitors of intraruminal lactic acid production. ( Caroon, JM; Clark, RD; Harrison, IT; Kluge, AF; Mathews, TR; Spires, HR; Unger, SH, 1981)
" A diagnosis of idiopathic lactic acidosis was established when the arterial blood pH was found to be 6."	3.64	THE CLINICAL SIGNIFICANCE OF ELEVATED BLOOD LACTATE. ( PHILLIPSON, EA; SPROULE, BJ, 1965)
"Plasma acidosis was not associated with the decline of PPO in a supramaximal trial with elite cyclists."	3.30	Plasma Acidosis and Peak Power after a Supramaximal Trial in Elite Sprint and Endurance Cyclists: Effect of Bicarbonate. ( Cairns, SP; Lindinger, MI; Maunder, ED; Mildenhall, MJ; Plews, DJ, 2023)
"Lactate acidosis is often observed in the tumor microenvironment (TME) of solid tumors."	3.01	Lactate acidosis and simultaneous recruitment of TGF-β leads to alter plasticity of hypoxic cancer cells in tumor microenvironment. ( Arora, MK; Banerjee, S; Kaithwas, G; Mishra, SS; Rastogi, S; Ravichandiran, V; Roy, S; Singh, L, 2023)
"Metabolic acidosis was induced in each horse twice, with a minimum 15-day interval after recovery from the first induction: the first time no treatment was administered (control group) and the second time horses were treated with an intravenous infusion of L84 solution, 100 ml/kg bwt for 5 h, beginning 3 h after the end of HCl infusion."	2.84	Intravenous administration of a polyionic solution containing 84 mEq/l of lactate resolves experimentally induced hyperchloraemic acidosis in horses. ( Dearo, AC; Fernandes, TM; Flaiban, KK; Lisbôa, JA; Pereira, PF; Romão, FT, 2017)
"Sodium bicarbonate (SB) was used as a positive control."	2.84	Chronic lactate supplementation does not improve blood buffering capacity and repeated high-intensity exercise. ( Artioli, GG; de Salles Painelli, V; Gonçalves, LS; Gualano, B; Nemezio, K; Oliveira, LF; Saunders, B; Yamaguchi, G, 2017)
" faecium in combination with Saccharomyces cerevisiae or Lactococcus lactis during a subacute ruminal acidosis (SARA) challenge."	2.80	Efficacy of the direct-fed microbial Enterococcus faecium alone or in combination with Saccharomyces cerevisiae or Lactococcus lactis during induced subacute ruminal acidosis. ( Chiquette, J; Girard, CL; Hindrichsen, IK; Lagrost, J; Li, S; Plaizier, JC; Talbot, G, 2015)
"Ruminal acidosis was induced by restricting feed to 50% of DMI:BW for 24 h followed by an intraruminal infusion of ground barley at 10% DMI:BW."	2.78	Duration of time that beef cattle are fed a high-grain diet affects the recovery from a bout of ruminal acidosis: short-chain fatty acid and lactate absorption, saliva production, and blood metabolites. ( Beauchemin, KA; Penner, GB; Schwaiger, T, 2013)
"Thirty consecutive patients with septic shock were prospectively included on ICU admission."	2.77	Defining metabolic acidosis in patients with septic shock using Stewart approach. ( Mallat, J; Michel, D; Salaun, P; Thevenin, D; Tronchon, L, 2012)
" During the challenge, the morning feeding was replaced by an intraruminal supply of wheat (readily fermentable starch), corn (slowly fermentable starch), or beet pulp (easily digestible fiber), dosed at 1."	2.75	Experimental feed induction of ruminal lactic, propionic, or butyric acidosis in sheep. ( Berger, C; Lettat, A; Martin, C; Morgavi, DP; Nozière, P; Silberberg, M, 2010)
"Milrinone was used in patients with pulmonary hypertension (MPAP >20 mmHg)."	2.73	The effect of milrinone on metabolism after cardiopulmonary bypass. ( Gerolioliou, K; Papakonstantinou, C; Spanos, P; Tatlis, A; Toumbouras, M, 2008)
""Lactic acidosis" is thus an inappropriate term as it indicates causality and in this review, we suggest that in the future, the term "hyperlactataemia-associated metabolic acidosis" should be used instead."	2.72	[Hyperlactataemia]. ( Andreasen, AS; Berg, RM; Iepsen, UW; Jeppesen, TE; Mohammad, M; Plovsing, RR, 2021)
"Metabolic acidosis is the most frequent acid-base disorder in the intensive care unit."	2.71	Conventional or physicochemical approach in intensive care unit patients with metabolic acidosis. ( Moviat, M; van der Hoeven, H; van Haren, F, 2003)
"Metabolic acidosis is a frequent complication of cardiopulmonary bypass (CPB)."	2.71	Metabolic acidosis developing during cardiopulmonary bypass is related to a decrease in strong ion difference. ( Alston, RP; Collinson, C; Cormack, L, 2004)
"Acute ruminal acidosis is a metabolic status defined by decreased blood pH and bicarbonate, caused by overproduction of ruminal D-lactate."	2.50	Ruminal acidosis in feedlot: from aetiology to prevention. ( Abuelo, A; Benedito, JL; Castillo, C; Hernández, J, 2014)
"Moderate to severe neonatal encephalopathy in asphyxiated term infants is associated with a high risk of cerebral palsy (especially quadriplegic or dyskinetic type) and/or cognitive disorders."	2.44	[Definition of intrapartum asphyxia and effects on outcome]. ( Zupan Simunek, V, 2008)
"In addition, the management of hemorrhagic shock is continuing to evolve and challenge the dogmatic practices of normotensive resuscitation."	2.42	Targeted resuscitation strategies after injury. ( Bilkovski, RN; Horst, HM; Rivers, EP, 2004)
"Severe Acidosis was present in 35."	1.72	Laboratory Markers of Acidosis and Mortality in Cardiogenic Shock: Developing a Definition of Hemometabolic Shock. ( Baran, DA; Barsness, GW; Henry, TD; Jentzer, JC; Kashani, KB; Patel, PC; Van Diepen, S; Wiley, BM, 2022)
"Metabolic transformation of cancer cells leads to the accumulation of lactate and significant acidification in the tumor microenvironment."	1.62	Inhibition of Mitochondrial Metabolism Leads to Selective Eradication of Cells Adapted to Acidic Microenvironment. ( Dvořák, A; Koncošová, M; Křížová, I; Rimpelová, S; Ruml, T; Rumlová, M; Tomášová, P; Vítek, L; Vrzáčková, N; Zelenka, J, 2021)
"Extracellular acidosis is considered as a hallmark of most human tumors, which plays an important role in promoting tumor malignant and aggressive phenotype in tumorigenesis."	1.56	Differential metabolic responses in breast cancer cell lines to acidosis and lactic acidosis revealed by stable isotope assisted metabolomics. ( Cheng, J; Dong, F; Gao, J; Guo, Z; Li, H; Sun, B; Wu, S; Yan, X; Yang, J, 2020)
"Cerebral ischemia is a serious possible manifestation of diabetic vascular disease."	1.48	Acidosis mediates recurrent hypoglycemia-induced increase in ischemic brain injury in treated diabetic rats. ( Dave, KR; Perez-Pinzon, MA; Rehni, AK; Shukla, V, 2018)
"Metabolic acidosis was defined by the presence of pH <7."	1.46	Preoperative metabolic acidosis in infants with gastroschisis. ( Almudeer, A; El-Naggar, W; Vincer, M; Yanchar, NL, 2017)
"Sepsis is a major public health problem as well as one of the leading causes of preventable death in children because of failure to recognise the early signs and symptoms and to resuscitate rapidly."	1.46	Importance of measuring lactate levels in children with sepsis. ( Anil, N, 2017)
"Ruminal acidosis is a prevalent disorder among dairy cows and feedlot cattle, which can significantly impair their health and productivity."	1.46	Potential influence of dairy propionibacteria on the growth and acid metabolism of Streptococcus bovis and Megasphaera elsdenii. ( Baines, SK; Evans, CA; King, S; Luo, J; Ranadheera, CS, 2017)
"Metabolic acidosis is one of the many metabolic derangements triggered by severe trauma/hemorrhagic shock, also including enhanced proteolysis, lipid mobilization, as well as traumatic diabetes."	1.43	Plasma First Resuscitation Reduces Lactate Acidosis, Enhances Redox Homeostasis, Amino Acid and Purine Catabolism in a Rat Model of Profound Hemorrhagic Shock. ( Banerjee, A; Chapman, MP; D'Alessandro, A; Fragoso, M; Gonzalez, E; Hansen, KC; Moore, EE; Moore, HB; Morton, AP; Nemkov, T; Sauaia, A; Silliman, CC; Slaughter, A; Wither, MJ, 2016)
"Metabolic acidosis has been proposed as the gold standard to define shock in trauma patients."	1.42	Determining the utility of metabolic acidosis for trauma patients in the emergency department. ( Caputo, ND; Fraser, RM; Kanter, M; Simon, R; Summersgill, A, 2015)
"Acidosis is a well-known factor leading to coagulopathy."	1.42	Moderate-degree acidosis is an independent determinant of postoperative bleeding in cardiac surgery. ( Baryshnikova, E; Ranucci, M; Scolletta, S; Simeone, F, 2015)
"Severe falciparum malaria is commonly complicated by metabolic acidosis."	1.42	The role of previously unmeasured organic acids in the pathogenesis of severe malaria. ( Charunwatthana, P; Chotinavich, K; Day, NP; Dondorp, AM; Douthwaite, S; Faiz, MA; Ghose, A; Hassan, MM; Herdman, MT; Hossain, MA; Kingston, HW; Leepipatpiboon, N; Leopold, SJ; Maude, RJ; Mishra, S; Mohanty, S; Plewes, K; Silamut, K; Sriboonvorakul, N; Tarning, J; White, NJ; Woodrow, CJ, 2015)
"The acute coagulopathy of trauma is associated with hypoperfusion, metabolic acidosis and an increased mortality rate."	1.39	Base deficit as an early marker of coagulopathy in trauma. ( Cheddie, S; Hardcastle, TC; Muckart, DJ, 2013)
"Hyperkalemia is a clinically important electrolyte imbalance in neonatal diarrheic calves that has previously been associated with skeletal muscle weakness and life-threatening cardiac arrhythmias."	1.39	Hyperkalemia in neonatal diarrheic calves depends on the degree of dehydration and the cause of the metabolic acidosis but does not require the presence of acidemia. ( Constable, PD; Knubben-Schweizer, G; Lorch, A; Lorenz, I; Sauter-Louis, C; Trefz, FM, 2013)
"Secondary hyperparathyroidism is not involved in postoperative bone loss."	1.39	Roux-en-Y gastric bypass surgery reduces bone mineral density and induces metabolic acidosis in rats. ( Abegg, K; Bueter, M; Gehring, N; Liesegang, A; Lutz, TA; Schiesser, M; Wagner, CA, 2013)
"Despite treatment, this syndrome complicated the interpretation of blood glucose readings as a measure of islet graft function and resulted in death or the need for euthanasia in all seven animals."	1.38	A syndrome of severe hypoglycemia and acidosis in young immunosuppressed diabetic monkeys and pigs-association with sepsis. ( Bottino, R; Cooper, DK; Dons, EM; Echeverri, GJ; Rigatti, LH; van der Windt, DJ; Wagner, R; Wijkstrom, M; Zhou, H, 2012)
"Pediatric medication dosing and administration, faced with inherent challenges of dose to body weight adjustment and variable delivery vehicles, may lead to inadvertent errors effectively resulting in overdose."	1.37	Zidovudine (AZT) overdose in a healthy newborn receiving postnatal prophylaxis. ( Esteban-Cruciani, N; Hoffman, RS; Lee, S; Livshits, Z; Nelson, LS, 2011)
"Nutritional interventions for intrauterine growth restriction (IUGR) have raised concerns for fetal toxicity, the mechanisms of which are unknown."	1.35	Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction. ( Barry, JS; Brown, LD; Hay, WW; Limesand, SW; Rozance, PJ, 2009)
"Alzheimer's disease is characterized by beta-amyloid plaques, tau pathology, cell death of cholinergic neurons, inflammatory processes and cerebrovascular damage."	1.35	[Does acidosis in brain play a role in Alzheimer's disease?]. ( Humpel, C; Pirchl, M, 2009)
"Ethylene glycol ingestion was subsequently diagnosed."	1.34	Falsely elevated point-of-care lactate measurement after ingestion of ethylene glycol. ( Brindley, DN; Brindley, PG; Butler, MS; Cembrowski, G, 2007)
" The aim of the present study was to investigate if spiny dogfish were equally sensitive to copper exposure and whether the toxic mechanisms were the same."	1.34	Copper toxicity in the spiny dogfish (Squalus acanthias): urea loss contributes to the osmoregulatory disturbance. ( Bucking, CP; De Boeck, G; Franklin, NM; Hattink, J; Walsh, PJ; Wood, CM; Wood, S, 2007)
"Metabolic acidosis is common in patients with cardiac arrest and is conventionally considered to be essentially due to hyperlactatemia."	1.33	A quantitative analysis of the acidosis of cardiac arrest: a prospective observational study. ( Bellomo, R; Makino, J; Morimatsu, H; Uchino, S, 2005)
"Alzheimer's disease is a progressive brain disorder which is neuropathologically characterized by an increased number of beta-amyloid plaques, tau pathology and synapse loss."	1.33	Effects of acidosis on brain capillary endothelial cells and cholinergic neurons: relevance to vascular dementia and Alzheimer's disease. ( Humpel, C; Marksteiner, J; Pirchl, M, 2006)
" Our results demonstrate that glucose per se, but not lactate, in combination with acidosis mediates the detrimental hyperglycemic effect through a mechanism independent of ionotropic glutamate receptors."	1.32	Glucose but not lactate in combination with acidosis aggravates ischemic neuronal death in vitro. ( Asztély, F; Cronberg, T; Rytter, A; Söder, A; Wieloch, T, 2004)
"Severe hypoxemia induces similar alterations of renal excretion in newborn piglets."	1.31	Effect of severe normocapnic hypoxia on renal function in growth-restricted newborn piglets. ( Bauer, R; Walter, B; Zwiener, U, 2000)
"Congenital heart disease is the leading cause of death in the first year after birth."	1.31	Prenatal diagnosis of congenital heart disease affects preoperative acidosis in the newborn patient. ( Bennink, GB; Brenner, JI; Copel, JA; Hitchcock, JF; Kleinman, CS; Lisowski, LA; Meijboom, EJ; Stoutenbeek, P; Verheijen, PM, 2001)
"Identified causes of colic included gastric ulceration, small intestinal volvulus, cecal intussusception, cecal rupture, colonic impaction, left dorsal colon displacement, right dorsal colon displacement, colonic volvulus, colitis, peritonitis, and uterine torsion."	1.31	Determination of the acid-base status in 50 horses admitted with colic between December 1998 and May 1999. ( Johnson, PJ; Nappert, G, 2001)
"1."	1.31	The exercise metaboreflex is maintained in the absence of muscle acidosis: insights from muscle microdialysis in humans with McArdle's disease. ( Haller, RG; MacLean, DA; Saltin, B; Sander, M; Vissing, J; Vissing, SF, 2001)
"The mean occlusion time until cardiac arrest was 14."	1.31	Reduced postnatal cerebral glucose metabolism measured by PET after asphyxia in near term fetal lambs. ( Hellström-Westas, L; Hernandez-Andrade, E; Ley, D; Lingman, G; Marsal, K; Ohlsson, T; Oskarsson, G; Pesonen, E; Sandell, A; Strand, SE; Thorngren-Jerneck, K; Werner, O, 2001)
"Louis Animal Emergency Clinic South for treatment of enteritis caused by parvovirus infection were used in our study."	1.31	Determination of serum organic acids in puppies with naturally acquired parvoviral enteritis. ( Dunphy, E; Mann, FA; Nappert, G; Ruben, D, 2002)
"Children with coma and respiratory distress (CM + RD) had greater evidence of renal dysfunction, lower mean pH and higher mean plasma osmolality than those with respiratory distress (RD) or coma (CM) as isolated findings (mean urea 10."	1.30	Acidosis in severe childhood malaria. ( English, M; Lowe, B; Marsh, K; Mosobo, M; Obiero, J; Sauerwein, R; Waruiru, C, 1997)
"Lactic acidosis was not the cause of the acidemia."	1.29	Hypertonic saline-dextran resuscitation from hemorrhagic shock induces transient mixed acidosis. ( Kramer, GC; Moon, PF, 1995)
"It is suggested that cerebral ischemia acidosis could be improved by hemodilution, in addition to the clearance of lactate acid."	1.29	[Hemodilution therapy for cerebral ischemic acidosis]. ( Shi, YS, 1993)
"7."	1.29	Metabolic acidosis is a potent stimulus for cellular inorganic phosphate generation in uraemia. ( Baker, FE; Bevington, A; Brough, D; Hattersley, J; Walls, J, 1995)
"Acid-base balance in cerebral infarction might be affected not only by lactate production but also by complicated interactions with tissue edema and some other factors."	1.29	Dissociation between lactate accumulation and acidosis in middle cerebral artery-occluded rats assessed by 31P and 1H NMR metabolic images under a 2-T magnetic field. ( Inubushi, T; Ishii, H; Morikawa, S; Shigemori, S; Takahashi, K, 1996)
"Ibuprofen pretreatment increases arterial pressure and reduces mortality in endotoxic dogs."	1.28	Cardiovascular response in canine endotoxic shock: effect of ibuprofen pretreatment. ( Pinsky, MR, 1992)
"A ten-month-old infant with pyruvate dehydrogenase deficiency received anaesthesia on two occasions, once for a laparotomy and once for a tracheostomy."	1.27	Anaesthesia and pyruvate dehydrogenase deficiency. ( Dierdorf, SF; McNiece, WL, 1983)
"During respiratory acidosis, this value was 0."	1.27	Role of acidosis in early contractile dysfunction during ischemia: evidence from pHo measurements. ( Couper, GS; Hiltbrand, B; Shine, KI; Weiss, J, 1984)
"Metabolic acidosis is due to lactic acidosis, ketoacidosis and acetic acidosis but the degree of each varies from patient to patient."	1.27	Metabolic acidosis in the alcoholic: a pathophysiologic approach. ( Halperin, ML; Hammeke, M; Josse, RG; Jungas, RL, 1983)
"Hyperglycemia was found consistently within 12 hours after injury (224 +/- 98 mg/dl, P less than 0."	1.27	Hyperglycemia, cerebrospinal fluid lactic acidosis, and cerebral blood flow in severely head-injured patients. ( De Salles, AA; Muizelaar, JP; Young, HF, 1987)
"9 mmol/l, respectively, developed in three patients with hyperosmolar syndromes (two hypernatremic, 417 and 415 mosmol/kg H2O; one hyperglycemic 437 mosmol/kg H2O) during rehydration treatment with 5% fructose in water (fructose dosage 0."	1.27	Fructose-induced hyperlactemia in hyperosmolar syndromes. ( Druml, W; Kleinberger, G; Laggner, A; Lenz, K; Schneeweiss, B, 1986)
"The hyperproteinemia was attributed to dehydration, the lactic acidemia to shock, and the hyperphosphatemia to acidosis and transient renal failure."	1.27	The acidosis of cholera. Contributions of hyperproteinemia, lactic acidemia, and hyperphosphatemia to an increased serum anion gap. ( Butler, T; Jones, PK; Rabbani, GH; Wang, F, 1986)
" Samples were taken at time 0, then every 2 h for 48 h after a switch from an alfalfa diet to C, or dosing with G."	1.27	Net portal absorption of lactate and volatile fatty acids in steers experiencing glucose-induced acidosis or fed a 70% concentrate diet ad libitum. ( Britton, RA; Harmon, DL; Prior, RL; Stock, RA, 1985)
"The symptoms of D-lactate encephalopathy are quite sensitive, but not necessarily specific for this disorder."	1.27	D-lactate encephalopathy. ( Eckfeldt, JH; Ludvigsen, CW; Pierpont, GL; Thurn, JR, 1985)
"In 31 cases of proved viral meningitis as with 58 cases of clinically diagnosed viral meningitis, levels were below 3."	1.26	Cerebrospinal fluid lactic acidosis in bacterial meningitis. ( Dorman, D; Eross, J; Silink, M, 1981)
"We conclude that with progressive hypoxemia, CMRO2 remains stable until oxygen demand exceeds oxygen delivery, resulting thereafter in a progressive reduction in CMRO2."	1.26	Canine cerebral metabolism and blood flow during hypoxemia and normoxic recovery from hypoxemia. ( Artru, AA; Michenfelder, JD, 1981)

Research

Studies (517)

Authors

Clinical Trials (10)

Trial Overview

Trial Outcomes

Cerebral Fractional Anisotropy Measured by Diffusion Weighted Magnetic Resonance Imaging

Timeframe	Studies, this research(%)	All Research%
pre-1990	138 (26.69)	18.7374
1990's	81 (15.67)	18.2507
2000's	132 (25.53)	29.6817
2010's	127 (24.56)	24.3611
2020's	39 (7.54)	2.80

Authors	Studies
Berg, RM	1
Jeppesen, TE	1
Mohammad, M	1
Andreasen, AS	1
Iepsen, UW	1
Plovsing, RR	1
Torres Yordán, NC	1
Lewis, AG	1
McElrath, TF	1
Tolan, NV	1
Greenberg, JA	1
Koncošová, M	1
Vrzáčková, N	1
Křížová, I	1
Tomášová, P	1
Rimpelová, S	1
Dvořák, A	1
Vítek, L	1
Rumlová, M	1
Ruml, T	1
Zelenka, J	1
Gant, CM	1
Gijzen, K	1
Josephus Jitta, N	1
de Landsheere, F	1
Saint-Marcoux, F	1
Haufroid, V	1
Dulaurent, S	2
Dewulf, JP	1
Boland, L	1
Laterre, PF	1
Hantson, P	1
Fan, Y	1
Xia, G	1
Jin, Y	1
Wang, H	3
Podušel, V	1
Morgošová, S	1
Majdák, P	1
Sadloňová, J	1
Jentzer, JC	2
Schrage, B	1
Patel, PC	2
Kashani, KB	2
Barsness, GW	2
Holmes, DR	1
Blankenberg, S	1
Kirchhof, P	1
Westermann, D	1
Sarmikasoglou, E	1
Ferrell, J	1
Vinyard, JR	1
Flythe, MD	1
Tuanyok, A	1
Faciola, AP	1
Ahmed, MG	1
Al-Sagheer, AA	1
El-Zarkouny, SZ	1
Elwakeel, EA	1
Nikvand, AA	1
Nouri, M	1
Gharibi, D	1
Rakhshandeh, R	1
Han, SJ	3
Zhou, ZW	3
Yang, C	3
Wei, KP	3
Ma, JZ	3
Chu, ZF	3
Gu, P	3
Mildenhall, MJ	1
Maunder, ED	1
Plews, DJ	1
Lindinger, MI	2
Cairns, SP	1
Ladde, JG	1
Miller, S	1
Chin, K	1
Feffer, C	1
Gulenay, G	1
Kepple, K	1
Hunter, C	1
Thundiyil, JG	1
Papa, L	1
Golder, HM	4
LeBlanc, SJ	1
Duffield, T	2
Rossow, HA	1
Bogdanich, R	1
Hernandez, L	1
Block, E	1
Rehberger, J	1
Smith, AH	1
Thomson, J	1
Lean, IJ	5
Rastogi, S	1
Mishra, SS	1
Arora, MK	1
Kaithwas, G	1
Banerjee, S	1
Ravichandiran, V	1
Roy, S	1
Singh, L	1
Zhao, X	1
Zhang, Y	2
He, B	1
Han, Y	1
Shen, B	1
Zang, Y	1
Tanemoto, M	2
Yamada, S	1
Kimura, T	1
Yokoyama, T	1
Okazaki, Y	1
Abdel Shaheed, C	1
Carland, JE	1
Graham, GG	1
Stocker, SL	1
Smith, G	1
Hicks, M	1
Williams, KM	1
Furlong, T	1
Macdonald, P	1
Greenfield, JR	2
Smith, FC	1
Chowdhury, G	1
Day, RO	1
Weemaes, M	1
Hiele, M	1
Vermeersch, P	1
Bacchin, R	1
Feoli, A	1
Morigi, A	1
Ghisi, D	1
Greggi, T	1
Vanspranghels, R	1
De Jonckheere, J	1
Drumez, E	1
Lauriot Dit Prevost, A	1
Sharma, D	1
Ghesquiere, L	1
Storme, L	1
Houfflin-Debarge, V	1
Garabedian, C	1
Bowe, S	1
Staff, AC	1
Sugulle, M	1
Pohanka, M	1
Lefrère, B	1
Ecochard-Dugelay, E	1
Mosca, A	1
Benoist, JF	1
Hugot, JP	1
Imbard, A	1
Cheng, CF	1
Hsu, WC	1
Kuo, YH	1
Chen, TW	1
Kuo, YC	1
Baumann, L	1
Studhalter, M	1
Nee, J	1
Koerner, R	1
Zickler, D	1
Schroeder, T	2
Enghard, P	1
Nibbe, L	1
Hasper, D	1
Buder, R	1
Leithner, C	1
Ploner, CJ	1
Eckardt, KU	1
Storm, C	1
Kruse, JM	1
Nakamura, M	1
Imamura, T	1
Cortellazzo Wiel, L	1
Conversano, E	1
Carlone, G	1
Di Leo, G	1
Gortani, G	1
Zanchi, C	1
Barbi, E	1
Messonnier, LA	1
Bartolucci, P	1
d'Humières, T	1
Dalmais, E	1
Lacour, JR	1
Freund, H	1
Galactéros, F	1
Féasson, L	1
Gao, J	1
Guo, Z	1
Cheng, J	1
Sun, B	1
Yang, J	1
Li, H	1
Wu, S	1
Dong, F	1
Yan, X	1
Phoophiboon, V	1
Singhagowinta, P	1
Boonkaya, S	1
Sriprasart, T	1
Cohen, ET	1
Su, MK	1
Biary, R	1
Hoffman, RS	2
Fenu, EM	1
O'Neill, SS	1
Insuasti-Beltran, G	1
Pettenati, MJ	1
Giffen, M	1
Harrison, WT	1
Bergstedt, JH	1
Pfalzgraff, T	1
Skov, PV	1
Holzmann, M	2
Nordström, L	2
Steer, P	1
Wiley, BM	1
Baran, DA	1
Henry, TD	1
Van Diepen, S	1
Wang, J	2
Applefeld, WN	1
Sun, J	1
Solomon, SB	1
Feng, J	1
Couse, ZG	1
Risoleo, TF	1
Danner, RL	1
Tejero, J	1
Lertora, J	1
Alipour, E	1
Basu, S	1
Sachdev, V	1
Kim-Shapiro, DB	1
Gladwin, MT	1
Klein, HG	1
Natanson, C	1
Annoni, F	1
Peluso, L	1
Gouvêa Bogossian, E	1
Creteur, J	1
Zanier, ER	1
Taccone, FS	1
Correia-Oliveira, CR	1
Lopes-Silva, JP	1
Bertuzzi, R	1
McConell, GK	1
Bishop, DJ	2
Lima-Silva, AE	1
Kiss, MAPD	1
Hagenmaier, JA	1
Reinhardt, CD	1
Bartle, SJ	1
Henningson, JN	1
Ritter, MJ	1
Calvo-Lorenzo, MS	1
Vogel, GJ	1
Guthrie, CA	1
Siemens, MG	1
Thomson, DU	1
Heireman, L	1
Mahieu, B	1
Helbert, M	1
Uyttenbroeck, W	1
Stroobants, J	1
Piqueur, M	1
El-Naggar, W	1
Almudeer, A	1
Vincer, M	1
Yanchar, NL	1
Dyer, RA	1
Emmanuel, A	1
Adams, SC	1
Lombard, CJ	1
Arcache, MJ	1
Vorster, A	1
Wong, CA	1
Higgins, N	1
Reed, AR	1
James, MF	1
Joolay, Y	1
Schulein, S	1
van Dyk, D	1
Masevicius, FD	1
Rubatto Birri, PN	1
Risso Vazquez, A	1
Zechner, FE	1
Motta, MF	1
Valenzuela Espinoza, ED	1
Welsh, S	1
Guerra Arias, EF	1
Furche, MA	1
Berdaguer, FD	1
Dubin, A	3
Gaddam, M	1
Velagapudi, RK	1
Abu Sitta, E	1
Kanzy, A	1
Kettritz, R	1
Ritter, T	1
Rudolph, B	1
Luft, FC	1
Anil, N	1
Kohen, CJ	1
Hopper, K	1
Kass, PH	1
Epstein, SE	1
Lambert, FN	1
Treberg, JR	1
Anderson, WG	1
Brandt, C	1
Evans, AN	1
Sagar, AS	1
Jimenez, CA	1
Mckelvy, BJ	1
Rehni, AK	1
Shukla, V	1
Perez-Pinzon, MA	1
Dave, KR	1
Zhao, C	1
Liu, G	1
Li, X	2
Guan, Y	1
Wang, Y	1
Yuan, X	1
Sun, G	1
Wang, Z	2
Jovandaric, MZ	1
Milenkovic, SJ	1
Drangsholt, E	1
Vangstad, M	1
Zakharov, S	1
Hovda, KE	1
Jacobsen, D	1
Cummins, G	1
Kremer, J	1
Bernassau, A	1
Brown, A	1
Bridle, HL	1
Schulze, H	1
Bachmann, TT	1
Crichton, M	1
Denison, FC	1
Desmulliez, MPY	1
Chycki, J	1
Kurylas, A	1
Maszczyk, A	1
Golas, A	1
Zajac, A	1
Jiawan, A	1
Tandjung, K	1
Alarcon, P	1
Hidalgo, AI	1
Manosalva, C	1
Cristi, R	1
Teuber, S	1
Hidalgo, MA	1
Burgos, RA	1
Andresen, JH	1
Saugstad, OD	1
Leopold, SJ	2
Apinan, S	1
Ghose, A	2
Kingston, HW	2
Plewes, KA	1
Hossain, A	1
Dutta, AK	1
Paul, S	1
Barua, A	1
Sattar, A	1
Day, NPJ	1
Tarning, J	2
Winterberg, M	1
White, NJ	4
Dondorp, AM	3
Robergs, RA	2
Mase, H	1
Ogawa, Y	1
Takeuchi, J	1
Genda, Y	1
Ichiba, S	1
Sakamoto, A	1
Choserot, M	1
Lamy, C	1
Perdriolle-Galet, E	1
Behm-Gauchotte, E	1
Coevet, V	1
Morel, O	1
Jenkins, DM	1
Murray, WB	1
Kennett, MJ	1
Hughes, EL	1
Werner, JR	1
Mokarami, P	1
Wiberg, N	1
Olofsson, P	2
Tobias, G	1
Benatti, FB	1
de Salles Painelli, V	3
Roschel, H	1
Gualano, B	3
Sale, C	1
Harris, RC	1
Lancha, AH	1
Artioli, GG	3
Satterly, SA	1
Martin, M	1
Wingerd, M	1
Hempel, J	1
Hoffer, Z	1
Stallings, JD	1
Mayer, A	2
Vaupel, P	2
Cheddie, S	1
Muckart, DJ	1
Hardcastle, TC	1
Racinet, C	2
Richalet, G	2
Corne, C	2
Faure, P	1
Peresse, JF	2
Leverve, X	1
Fine-Goulden, MR	1
Durward, A	2
Trefz, FM	2
Constable, PD	1
Sauter-Louis, C	2
Lorch, A	2
Knubben-Schweizer, G	1
Lorenz, I	2
Abegg, K	1
Gehring, N	1
Wagner, CA	2
Liesegang, A	1
Schiesser, M	1
Bueter, M	1
Lutz, TA	1
Dani, C	1
Bresci, C	1
Berti, E	1
Lori, S	1
Di Tommaso, MR	1
Pratesi, S	1
Grosche, A	1
Morton, AJ	1
Graham, AS	1
Polyak, MM	1
Freeman, DE	1
White, CR	1
Doherty, DA	1
Newnham, JP	1
Pennell, CE	1
Schwaiger, T	1
Beauchemin, KA	1
Penner, GB	1
Porta, CR	1
Nelson, D	1
McVay, D	1
Salgar, S	1
Eckert, M	1
Izenberg, S	1
Martin, MJ	1
Ho, JD	2
Dawes, DM	2
Nystrom, PC	1
Collins, DP	1
Nelson, RS	1
Moore, JC	1
Miner, JR	2
Salomonsen, M	1
Hardersen, R	1
Carlsson, M	1
Nielsen, EW	1
Long, M	1
Feng, WJ	1
Li, P	1
He, RX	1
Yu, LH	1
He, JB	1
Jing, WY	1
Li, YM	1
Liu, GW	1
Ikonomidis, I	1
Makavos, G	1
Nikitas, N	1
Paraskevaidis, I	1
Diamantakis, A	1
Kopterides, P	1
Theodorakopoulou, M	1
Parissis, J	1
Lekakis, J	1
Armaganidis, A	1
Dimopoulou, I	1
Chung, W	1
Baguet, A	1
Bex, T	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Is There Any Effect of Maternal Dietary Acid Load During Pregnancy on Arising Gestational Diabetes Mellitus?[NCT03790579]		80 participants (Actual)	Observational	2014-01-05	Completed
Neuroprotective Effects of Hypothermia Combined With Inhaled Xenon Following Perinatal Asphyxia[NCT00934700]		92 participants (Actual)	Interventional	2012-02-29	Completed
Proton Pump Inhibitors (PPI) as a New Strategy for Therapy in Sepsis: Clinical Trial to Reduce Severity of Organ Failure and in Vitro Experiments to Search Specific Hallmarks in Monocytes From Septic Patients and to Characterize the Mechanism of Action of[NCT03452865]	Phase 3	300 participants (Anticipated)	Interventional	2020-01-28	Recruiting
An Open Monocentric Observational Study to Investigate Fluid- and Electrolyte Balance in Post Cardiac-surgery Patients in the ICU[NCT02914782]		176 participants (Actual)	Observational [Patient Registry]	2016-09-30	Completed
Strong Ion Gap as Prognostic Indicator for Adult Patients Admitted With Shock to the Intensive Care Units[NCT02652364]		112 participants (Actual)	Observational	2015-10-31	Completed
Randomized, Long-Term Administration of pH-Neutral PD Solutions Containing Lactate (BALANCE) or Bicarbonate (BICAVERA) in Children[NCT01632046]	Phase 4	42 participants (Actual)	Interventional	2004-03-31	Completed
Comparative Analysis Between Ringer's Lactate vs Acetate Containing Balanced Crystalloid Solution (Plasma Lyte-A) as Cardiopulmonary Bypass Prime[NCT03043131]	Phase 3	60 participants (Anticipated)	Interventional	2017-02-10	Not yet recruiting
Sodium Bicarbonate to Treat Severe Acidosis in the Critically Ill : A Multiple Center Randomized Clinical Trial (BICAR-ICU)[NCT02476253]	Phase 3	400 participants (Anticipated)	Interventional	2015-05-05	Recruiting
The Effect of Intra Aortic Balloon Pump Early Insertion on Mortality in Post Cardiac Arrest Patients With Acute Coronary Syndrome[NCT03638609]		102 participants (Anticipated)	Interventional	2017-10-23	Recruiting
Pharmacotoxicology of Trichloroethylene Metabolites: Short-term Effect of DCA on in Vivo Tyrosine Catabolism and MAAI Expression[NCT00865514]		2 participants (Actual)	Interventional	2011-08-31	Terminated (stopped due to Difficulty in obtaining the solution from the compounding pharmacies caused a two year delay in start-up; the funding ended prior to study completion.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"Fractional anisotropy (FA) is a measure of tissue integrity in white matter tracts measured by diffusion tensor MRI, and it has been used in work in animals to assess potential neuroprotectants and can be used to predict subsequent neurological outcomes after birth asphyxia, including in infants treated with moderate hypothermia.~It is a scalar value between 0-1 that describe anisotropy of a diffusion process. A value of zero means that diffusion is unrestricted (or equally restricted) in all directions. A value of one means that diffusion occurs only along one axis and is fully restricted along all other directions or similar.~Fractional anisotropy data were extracted froma mask of the posterior limb of the internal capsule via tract-based spatial statistics. *Coefficient of variation=√(exp(var)-1), where var is the variance on the log scale" (NCT00934700)
Timeframe: 10 days

Lactate (Lac) / N Acetyl Aspartate (NAA) Ratio on Magnetic Resonance Spectroscopy

Intervention	units on a scale (Mean)
Combination of Hypothermia and Xenon	0.40
Hypothermia and Standard Intensive Care	0.40

Cerebral Lac/NAA ratio measured by magnetic resonance spectroscopy in patents (NCT00934700)
Timeframe: 10 days

Article	Year
[Hyperlactataemia]. Ugeskrift for laeger, 2021, 08-16, Volume: 183, Issue:33 Topics: Acidosis; Acidosis, Lactic; Humans; Lactic Acid	2021
Lactate acidosis and simultaneous recruitment of TGF-β leads to alter plasticity of hypoxic cancer cells in tumor microenvironment. Pharmacology & therapeutics, 2023, Volume: 250 Topics: Acidosis; Humans; Hypoxia; Lactic Acid; Neoplasms; Transforming Growth Factor beta; Tumor Microenvir	2023
Is the use of metformin in patients undergoing dialysis hazardous for life? A systematic review of the safety of metformin in patients undergoing dialysis. British journal of clinical pharmacology, 2019, Volume: 85, Issue:12 Topics: Acidosis; Diabetes Mellitus, Type 2; Drug Monitoring; Humans; Hypoglycemic Agents; Kidney; Kidney Di	2019
D-Lactic Acid as a Metabolite: Toxicology, Diagnosis, and Detection. BioMed research international, 2020, Volume: 2020 Topics: Acidosis; Animals; Humans; Lactic Acid; Metabolic Networks and Pathways; Metabolome	2020
Practical Management of ECPELLA. International heart journal, 2020, Nov-28, Volume: 61, Issue:6 Topics: Acidosis; Assisted Circulation; Combined Modality Therapy; Extracorporeal Membrane Oxygenation; Femo	2020
Brain Protection after Anoxic Brain Injury: Is Lactate Supplementation Helpful? Cells, 2021, 07-06, Volume: 10, Issue:7 Topics: Acidosis; Animals; Brain Injuries, Traumatic; Cell Death; Cerebrovascular Circulation; Energy Metabo	2021
Sensors for Fetal Hypoxia and Metabolic Acidosis: A Review. Sensors (Basel, Switzerland), 2018, Aug-13, Volume: 18, Issue:8 Topics: Acidosis; Female; Fetal Hypoxia; Fetal Monitoring; Humans; Labor, Obstetric; Lactic Acid; Pregnancy;	2018
Invited review: Quantifying proton exchange from chemical reactions - Implications for the biochemistry of metabolic acidosis. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2019, Volume: 235 Topics: Acidosis; Alkalosis; Bicarbonates; Body Fluids; Glycolysis; Humans; Hydrogen-Ion Concentration; Lact	2019
Hypoxia, lactate accumulation, and acidosis: siblings or accomplices driving tumor progression and resistance to therapy? Advances in experimental medicine and biology, 2013, Volume: 789 Topics: Acidosis; Disease Progression; Drug Resistance, Neoplasm; Humans; Hypoxia; Lactic Acid; Neoplasms	2013
How to use lactate. Archives of disease in childhood. Education and practice edition, 2014, Volume: 99, Issue:1 Topics: Acidosis; Adult; Biomarkers; Child; Child, Preschool; Cohort Studies; Female; Humans; Infant; Infant	2014
Ruminal acidosis in feedlot: from aetiology to prevention. TheScientificWorldJournal, 2014, Volume: 2014 Topics: Acidosis; Animal Feed; Animals; Lactic Acid; Rumen	2014
Intrapartum fetal scalp lactate sampling for fetal assessment in the presence of a non-reassuring fetal heart rate trace. The Cochrane database of systematic reviews, 2015, May-01, Issue:5 Topics: Acidosis; Biomarkers; Blood Specimen Collection; Cardiotocography; Female; Fetal Death; Fetal Distre	2015
Foetal scalp blood sampling during labour for pH and lactate measurements. Best practice & research. Clinical obstetrics & gynaecology, 2016, Volume: 30 Topics: Acidosis; Asphyxia Neonatorum; Blood Specimen Collection; Cerebral Palsy; Female; Fetal Blood; Fetal	2016
Umbilical lactate as a measure of acidosis and predictor of neonatal risk: a systematic review. BJOG : an international journal of obstetrics and gynaecology, 2017, Volume: 124, Issue:4 Topics: Acidosis; Apgar Score; Female; Fetal Blood; Fetal Distress; Humans; Hydrogen-Ion Concentration; Infa	2017
Deaths in custody: are some due to electronic control devices (including TASER devices) or excited delirium? Journal of forensic and legal medicine, 2010, Volume: 17, Issue:1 Topics: Acidosis; Animals; Cause of Death; Confounding Factors, Epidemiologic; Delirium; Electroshock; Fever	2010
Intrapartum fetal scalp lactate sampling for fetal assessment in the presence of a non-reassuring fetal heart rate trace. The Cochrane database of systematic reviews, 2010, Mar-17, Issue:3 Topics: Acidosis; Biomarkers; Blood Specimen Collection; Cardiotocography; Female; Fetal Distress; Fetal Hyp	2010
Pathophysiologic changes due to TASER® devices versus excited delirium: potential relevance to deaths-in-custody? Journal of forensic and legal medicine, 2011, Volume: 18, Issue:4 Topics: Acidosis; Animals; Blood Glucose; Body Temperature; Catecholamines; Channelopathies; Conducted Energ	2011
Effects of acute alkalosis and acidosis on performance: a meta-analysis. Sports medicine (Auckland, N.Z.), 2011, Oct-01, Volume: 41, Issue:10 Topics: Acidosis; Alkalosis; Ammonium Chloride; Athletes; Athletic Performance; Buffers; Citrates; Female; H	2011
Tumor metabolism as modulator of immune response and tumor progression. Seminars in cancer biology, 2012, Volume: 22, Issue:4 Topics: Acidosis; Amino Acids; Animals; Biological Transport; Disease Progression; Glycolysis; Humans; Immun	2012
[Positional paper of the German working group "cardiopulmonary exercise testing" to ventilatory and metabolic (lactate) thresholds]. Deutsche medizinische Wochenschrift (1946), 2013, Volume: 138, Issue:6 Topics: Acidosis; Acidosis, Lactic; Anaerobic Threshold; Carbon Dioxide; Exercise Test; Germany; Humans; Lac	2013
[Rapid microanalysis of lactate in cord blood and at fetal scalp blood sampling]. Gynecologie, obstetrique & fertilite, 2004, Volume: 32, Issue:3 Topics: Acidosis; Apgar Score; Electron Probe Microanalysis; Female; Fetal Blood; Fetal Monitoring; Humans;	2004
Biochemistry of exercise-induced metabolic acidosis. American journal of physiology. Regulatory, integrative and comparative physiology, 2004, Volume: 287, Issue:3 Topics: Acidosis; Acidosis, Lactic; Animals; Buffers; Exercise; History, 18th Century; History, 20th Century	2004
Targeted resuscitation strategies after injury. Current opinion in critical care, 2004, Volume: 10, Issue:6 Topics: Acidosis; Algorithms; Humans; Hydrogen-Ion Concentration; Lactic Acid; Oxygen; Oxygen Consumption; R	2004
Bench-to-bedside review: oxygen debt and its metabolic correlates as quantifiers of the severity of hemorrhagic and post-traumatic shock. Critical care (London, England), 2005, Oct-05, Volume: 9, Issue:5 Topics: Acid-Base Equilibrium; Acidosis; Animals; Disease Models, Animal; Dogs; Humans; Hypovolemia; Hypoxia	2005
Recognition and treatment of acute cyanide poisoning. Journal of emergency nursing, 2006, Volume: 32, Issue:4 Suppl Topics: Acidosis; Acute Disease; Antidotes; Blood Gas Analysis; Causality; Cyanides; Decontamination; Diagno	2006
Measurement of acid-base resuscitation endpoints: lactate, base deficit, bicarbonate or what? Current opinion in critical care, 2006, Volume: 12, Issue:6 Topics: Acidosis; Bicarbonates; Catheterization, Swan-Ganz; Cell Hypoxia; Hemoglobins; Humans; Hydrogen-Ion	2006
Trauma and aggressive homeostasis management. Anesthesiology clinics, 2007, Volume: 25, Issue:1 Topics: Acidosis; Animals; Brain Injuries; Homeostasis; Humans; Hyperglycemia; Hypothermia; Lactic Acid; Sho	2007
Ruminal acidosis in beef cattle: the current microbiological and nutritional outlook. Journal of dairy science, 2007, Volume: 90 Suppl 1 Topics: Acidosis; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Cattle; Cattle Diseases;	2007
[Stewart's acid-base approach]. Wiener klinische Wochenschrift, 2007, Volume: 119, Issue:13-14 Topics: Acid-Base Equilibrium; Acidosis; Alkalosis; Anions; Bicarbonates; Cations; Diabetic Ketoacidosis; El	2007
Use of umbilical cord blood gas analysis in the assessment of the newborn. Archives of disease in childhood. Fetal and neonatal edition, 2007, Volume: 92, Issue:6 Topics: Acidosis; Blood Gas Analysis; Delivery, Obstetric; Fetal Blood; Fetal Monitoring; Humans; Infant, Ne	2007
[Fetal scalp blood sampling for pH and lactate measurement during labour]. Journal de gynecologie, obstetrique et biologie de la reproduction, 2008, Volume: 37 Suppl 1 Topics: Acidosis; Cerebral Palsy; Cesarean Section; Female; Fetal Blood; Fetal Hypoxia; Fetal Monitoring; He	2008
[Definition of intrapartum asphyxia and effects on outcome]. Journal de gynecologie, obstetrique et biologie de la reproduction, 2008, Volume: 37 Suppl 1 Topics: Acidosis; Apgar Score; Biomarkers; Brain Diseases; Cerebral Palsy; Female; Fetal Blood; Fetal Hypoxi	2008
Lactic acidosis in the brain: occurrence, triggering mechanisms and pathophysiological importance. Ciba Foundation symposium, 1982, Volume: 87 Topics: Acidosis; Animals; Blood Glucose; Brain; Brain Ischemia; Carbon Dioxide; Glucose; Hypoxia, Brain; In	1982
Cell damage in the brain: a speculative synthesis. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1981, Volume: 1, Issue:2 Topics: Acidosis; Animals; Biological Transport, Active; Brain Ischemia; Calcium; Cell Membrane; Cerebrovasc	1981
Prognostic value of blood lactate in critically ill patients. Resuscitation, 1984, Volume: 11, Issue:3-4 Topics: Acidosis; Acute Disease; Heart Arrest; Humans; Hypnotics and Sedatives; Intensive Care Units; Lactat	1984
pH control of lactic acid and keto acid production: a mechanism of acid-base regulation. Mineral and electrolyte metabolism, 1983, Volume: 9, Issue:4-6 Topics: Acid-Base Equilibrium; Acidosis; Animals; Feedback; Humans; Hydrogen-Ion Concentration; Keto Acids;	1983
Undesired effects of biguanide therapy. Adverse drug reactions and acute poisoning reviews, 1984,Autumn, Volume: 3, Issue:3 Topics: Acidosis; Biguanides; Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Drug Interact	1984
[Tissue chemoreceptors]. Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1982, Volume: 68, Issue:2 Topics: Acid-Base Imbalance; Acidosis; Acidosis, Respiratory; Animals; Bicarbonates; Blood Pressure; Carbon	1982
Enteral nutrition as primary therapy in short bowel syndrome. Gut, 1994, Volume: 35, Issue:1 Suppl Topics: Acidosis; Adaptation, Physiological; Animals; Enteral Nutrition; Food, Formulated; Glutamine; Humans	1994
Treatment of acute renal failure in intensive care patients. The International journal of artificial organs, 1996, Volume: 19, Issue:2 Topics: Acidosis; Acute Kidney Injury; Bicarbonates; Hemofiltration; Humans; Intensive Care Units; Lactates;	1996
Metabolic acidosis in the critically ill: lessons from physical chemistry. Kidney international. Supplement, 1998, Volume: 66 Topics: Acid-Base Equilibrium; Acidosis; Acidosis, Lactic; Carbon Dioxide; Chemical Phenomena; Chemistry, Ph	1998
In search of the optimal end points of resuscitation in trauma patients: a review. The Journal of trauma, 1998, Volume: 44, Issue:5 Topics: Acidosis; Biomarkers; Gastric Mucosa; Humans; Hydrogen-Ion Concentration; Lactic Acid; Oxygen; Resus	1998
Metabolic acidosis and nutritional status of patients receiving continuous ambulatory peritoneal dialysis (CAPD) The International journal of artificial organs, 1998, Volume: 21, Issue:4 Topics: Acidosis; Bicarbonates; Dietary Proteins; Humans; Kidney Failure, Chronic; Lactic Acid; Nutritional	1998
Protection of acid-base balance by pH regulation of acid production. The New England journal of medicine, 1998, Sep-17, Volume: 339, Issue:12 Topics: Acid-Base Equilibrium; Acidosis; Acids; Energy Metabolism; Humans; Hydrogen-Ion Concentration; Keto	1998
Blood lactate: biochemistry, laboratory methods, and clinical interpretation. Critical reviews in clinical laboratory sciences, 1991, Volume: 28, Issue:4 Topics: Acidosis; Exercise; Homeostasis; Humans; Lactates; Lactic Acid; Monitoring, Physiologic; Reference V	1991
New and old paradoxes. Acidosis and cardiopulmonary resuscitation. Circulation, 1989, Volume: 80, Issue:4 Topics: Acidosis; Animals; Buffers; Carbon Dioxide; Cardiac Output; Collateral Circulation; Coronary Circula	1989
Cellular and molecular events underlying epileptic brain damage. Annals of the New York Academy of Sciences, 1986, Volume: 462 Topics: Acidosis; Animals; Brain; Brain Damage, Chronic; Calcium; Cell Survival; Cerebral Infarction; Electr	1986
Disorders of the pyruvate dehydrogenase complex. Journal of inherited metabolic disease, 1986, Volume: 9, Issue:2 Topics: Acetyl Coenzyme A; Acetyltransferases; Acidosis; Brain; Carbon Dioxide; Child; Child, Preschool; Coe	1986
Regulation of glutamine metabolism in dog kidney in vivo. Kidney international, 1986, Volume: 29, Issue:1 Topics: Acid-Base Equilibrium; Acidosis; Adenosine Triphosphate; Alanine; Ammonia; Animals; Aspartic Acid; B	1986
The anaerobic threshold: definition, physiological significance and identification. Advances in cardiology, 1986, Volume: 35 Topics: Acidosis; Adult; Anaerobiosis; Glycolysis; Heart Diseases; Humans; Kinetics; Lactates; Lactic Acid;	1986
Anaerobic threshold: review of the concept and directions for future research. Medicine and science in sports and exercise, 1985, Volume: 17, Issue:1 Topics: Acidosis; Anaerobiosis; Animals; Glycolysis; Humans; Kinetics; L-Lactate Dehydrogenase; Lactates; La	1985
Anaerobic threshold: review of the concept and directions for future research. Medicine and science in sports and exercise, 1985, Volume: 17, Issue:1 Topics: Acidosis; Anaerobiosis; Energy Metabolism; Humans; Lactates; Lactic Acid; Muscle Contraction; Muscle	1985
The acyl-CoA dehydrogenation deficiencies. Recent advances in the enzymic characterization and understanding of the metabolic and pathophysiological disturbances in patients with acyl-CoA dehydrogenation deficiencies. Scandinavian journal of clinical and laboratory investigation. Supplementum, 1985, Volume: 174 Topics: Acidosis; Acyl Coenzyme A; Acyl-CoA Dehydrogenase, Long-Chain; Ammonia; Carboxylic Acids; Chemical P	1985

Article	Year
Hemorrhagic, hypovolemic shock resuscitated with Ringer's solution using bicarbonate versus lactate: A CONSORT-randomized controlled study comparing patient outcomes and blood inflammatory factors. Medicine, 2022, Nov-18, Volume: 101, Issue:46 Topics: Acidosis; Bicarbonates; Hemorrhage; Humans; Interleukin-6; Lactic Acid; Prospective Studies; Ringer'	2022
Hemorrhagic, hypovolemic shock resuscitated with Ringer's solution using bicarbonate versus lactate: A CONSORT-randomized controlled study comparing patient outcomes and blood inflammatory factors. Medicine, 2022, Nov-18, Volume: 101, Issue:46 Topics: Acidosis; Bicarbonates; Hemorrhage; Humans; Interleukin-6; Lactic Acid; Prospective Studies; Ringer'	2022
Hemorrhagic, hypovolemic shock resuscitated with Ringer's solution using bicarbonate versus lactate: A CONSORT-randomized controlled study comparing patient outcomes and blood inflammatory factors. Medicine, 2022, Nov-18, Volume: 101, Issue:46 Topics: Acidosis; Bicarbonates; Hemorrhage; Humans; Interleukin-6; Lactic Acid; Prospective Studies; Ringer'	2022
Hemorrhagic, hypovolemic shock resuscitated with Ringer's solution using bicarbonate versus lactate: A CONSORT-randomized controlled study comparing patient outcomes and blood inflammatory factors. Medicine, 2022, Nov-18, Volume: 101, Issue:46 Topics: Acidosis; Bicarbonates; Hemorrhage; Humans; Interleukin-6; Lactic Acid; Prospective Studies; Ringer'	2022
Hemorrhagic, hypovolemic shock resuscitated with Ringer's solution using bicarbonate versus lactate: A CONSORT-randomized controlled study comparing patient outcomes and blood inflammatory factors. Medicine, 2022, Nov-18, Volume: 101, Issue:46 Topics: Acidosis; Bicarbonates; Hemorrhage; Humans; Interleukin-6; Lactic Acid; Prospective Studies; Ringer'	2022
Hemorrhagic, hypovolemic shock resuscitated with Ringer's solution using bicarbonate versus lactate: A CONSORT-randomized controlled study comparing patient outcomes and blood inflammatory factors. Medicine, 2022, Nov-18, Volume: 101, Issue:46 Topics: Acidosis; Bicarbonates; Hemorrhage; Humans; Interleukin-6; Lactic Acid; Prospective Studies; Ringer'	2022
Hemorrhagic, hypovolemic shock resuscitated with Ringer's solution using bicarbonate versus lactate: A CONSORT-randomized controlled study comparing patient outcomes and blood inflammatory factors. Medicine, 2022, Nov-18, Volume: 101, Issue:46 Topics: Acidosis; Bicarbonates; Hemorrhage; Humans; Interleukin-6; Lactic Acid; Prospective Studies; Ringer'	2022
Hemorrhagic, hypovolemic shock resuscitated with Ringer's solution using bicarbonate versus lactate: A CONSORT-randomized controlled study comparing patient outcomes and blood inflammatory factors. Medicine, 2022, Nov-18, Volume: 101, Issue:46 Topics: Acidosis; Bicarbonates; Hemorrhage; Humans; Interleukin-6; Lactic Acid; Prospective Studies; Ringer'	2022
Hemorrhagic, hypovolemic shock resuscitated with Ringer's solution using bicarbonate versus lactate: A CONSORT-randomized controlled study comparing patient outcomes and blood inflammatory factors. Medicine, 2022, Nov-18, Volume: 101, Issue:46 Topics: Acidosis; Bicarbonates; Hemorrhage; Humans; Interleukin-6; Lactic Acid; Prospective Studies; Ringer'	2022
Plasma Acidosis and Peak Power after a Supramaximal Trial in Elite Sprint and Endurance Cyclists: Effect of Bicarbonate. Medicine and science in sports and exercise, 2023, 05-01, Volume: 55, Issue:5 Topics: Acidosis; Bicarbonates; Bicycling; Fatigue; Humans; Lactic Acid; Oxygen; Oxygen Consumption; Physica	2023
Acute effect of inspiratory resistive loading on sprint interval exercise performance in team-sport athletes. Respiratory physiology & neurobiology, 2020, Volume: 282 Topics: Acidosis; Adult; Athletes; Athletic Performance; Cross-Over Studies; High-Intensity Interval Trainin	2020
Acidosis, but Not Alkalosis, Affects Anaerobic Metabolism and Performance in a 4-km Time Trial. Medicine and science in sports and exercise, 2017, Volume: 49, Issue:9 Topics: Acidosis; Adult; Alkalosis; Aluminum Chloride; Aluminum Compounds; Athletic Performance; Bicycling;	2017
A randomised comparison of bolus phenylephrine and ephedrine for the management of spinal hypotension in patients with severe preeclampsia and fetal compromise. International journal of obstetric anesthesia, 2018, Volume: 33 Topics: Acidosis; Adult; Anesthesia, Obstetrical; Blood Pressure; Cesarean Section; Ephedrine; Female; Fetal	2018
Additive effects of beta-alanine and sodium bicarbonate on upper-body intermittent performance. Amino acids, 2013, Volume: 45, Issue:2 Topics: Acidosis; Adult; Athletes; Athletic Performance; beta-Alanine; Calcium Carbonate; Dietary Supplement	2013
Duration of time that beef cattle are fed a high-grain diet affects the recovery from a bout of ruminal acidosis: short-chain fatty acid and lactate absorption, saliva production, and blood metabolites. Journal of animal science, 2013, Volume: 91, Issue:12 Topics: Acidosis; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Cattle; Diet; Edible Gra	2013
Doubling of muscle carnosine concentration does not improve laboratory 1-hr cycling time-trial performance. International journal of sport nutrition and exercise metabolism, 2014, Volume: 24, Issue:3 Topics: Acidosis; Athletic Performance; beta-Alanine; Bicycling; Carnosine; Dietary Supplements; Exercise; H	2014
Experimental acute rumen acidosis in sheep: consequences on clinical, rumen, and gastrointestinal permeability conditions and blood chemistry. Journal of animal science, 2014, Volume: 92, Issue:9 Topics: 3-Hydroxybutyric Acid; Acidosis; Animals; Blood Glucose; Ceruloplasmin; Cross-Over Studies; Gastroin	2014
Effects of partial mixed rations and supplement amounts on milk production and composition, ruminal fermentation, bacterial communities, and ruminal acidosis. Journal of dairy science, 2014, Volume: 97, Issue:9 Topics: Acetates; Acidosis; Animals; Biomass; Butyrates; Butyrivibrio; Cattle; Diet; Dietary Fats; DNA, Bact	2014
Efficacy of the direct-fed microbial Enterococcus faecium alone or in combination with Saccharomyces cerevisiae or Lactococcus lactis during induced subacute ruminal acidosis. Journal of dairy science, 2015, Volume: 98, Issue:1 Topics: Acidosis; Acute-Phase Proteins; Adaptation, Physiological; Animals; Cattle; Cattle Diseases; Dairyin	2015
Intravenous administration of a polyionic solution containing 84 mEq/l of lactate resolves experimentally induced hyperchloraemic acidosis in horses. Equine veterinary journal, 2017, Volume: 49, Issue:1 Topics: Acid-Base Imbalance; Acidosis; Animals; Cross-Over Studies; Electrolytes; Female; Horse Diseases; Ho	2017
Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial. The Lancet. Neurology, 2016, Volume: 15, Issue:2 Topics: Acidosis; Anesthetics, Inhalation; Apgar Score; Aspartic Acid; Asphyxia Neonatorum; Combined Modalit	2016
Effects of a bacterial probiotic on ruminal pH and volatile fatty acids during subacute ruminal acidosis (SARA) in cattle. The Journal of veterinary medical science, 2016, Nov-01, Volume: 78, Issue:10 Topics: Acidosis; Ammonia; Animals; Bacteria; Cattle; Cattle Diseases; Circadian Rhythm; Fatty Acids, Volati	2016
Beta-alanine supplementation enhances judo-related performance in highly-trained athletes. Journal of science and medicine in sport, 2017, Volume: 20, Issue:4 Topics: Acidosis; Adolescent; Athletes; Athletic Performance; beta-Alanine; Dietary Supplements; Double-Blin	2017
Chronic lactate supplementation does not improve blood buffering capacity and repeated high-intensity exercise. Scandinavian journal of medicine & science in sports, 2017, Volume: 27, Issue:11 Topics: Acid-Base Equilibrium; Acidosis; Adult; Athletes; Athletic Performance; Calcium Compounds; Cross-Ove	2017
Prolonged TASER use on exhausted humans does not worsen markers of acidosis. The American journal of emergency medicine, 2009, Volume: 27, Issue:4 Topics: Acidosis; Adult; Biomarkers; Electric Injuries; Electric Stimulation; Electroshock; Fatigue; Female;	2009
Effect of pump prime on acidosis, strong-ion-difference and unmeasured ions during cardiopulmonary bypass. Anaesthesia and intensive care, 2009, Volume: 37, Issue:5 Topics: Acid-Base Equilibrium; Acidosis; Aged; Analysis of Variance; Blood Gas Analysis; Cardiopulmonary Byp	2009
Experimental feed induction of ruminal lactic, propionic, or butyric acidosis in sheep. Journal of animal science, 2010, Volume: 88, Issue:9 Topics: Acidosis; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Beta vulgaris; Butyric A	2010
Changes in peak leg power induced by successive judo bouts and their relationship to lactate production. Journal of sports sciences, 2010, Volume: 28, Issue:14 Topics: Acidosis; Adult; Exercise; Humans; Lactic Acid; Leg; Male; Martial Arts; Muscle Strength; Muscle, Sk	2010
Plasma pH does not influence the cerebral metabolic ratio during maximal whole body exercise. The Journal of physiology, 2011, Jan-15, Volume: 589, Issue:Pt 2 Topics: Acidosis; Adult; Brain; Energy Metabolism; Ergometry; Humans; Hydrogen-Ion Concentration; Lactic Aci	2011
Defining metabolic acidosis in patients with septic shock using Stewart approach. The American journal of emergency medicine, 2012, Volume: 30, Issue:3 Topics: Acid-Base Equilibrium; Acidosis; Aged; Anions; Blood Gas Analysis; Chlorides; Female; Humans; Intens	2012
Outcome of severe intrapartum acidemia diagnosed with fetal scalp blood sampling. Journal of perinatal medicine, 2011, Volume: 39, Issue:5 Topics: Acidosis; Female; Fetal Blood; Humans; Hydrogen-Ion Concentration; Hypoxia-Ischemia, Brain; Infant,	2011
pH buffering does not influence BDNF responses to exercise. International journal of sports medicine, 2012, Volume: 33, Issue:1 Topics: Acidosis; Adult; Athletes; Bicarbonates; Bicycling; Brain-Derived Neurotrophic Factor; Exercise; Hum	2012
Detecting activity-evoked pH changes in human brain. Proceedings of the National Academy of Sciences of the United States of America, 2012, May-22, Volume: 109, Issue:21 Topics: Acidosis; Adult; Animals; Bicarbonates; Brain; Brain Mapping; Buffers; Carbon Dioxide; Cerebrovascul	2012
Effect of the dialysis fluid buffer on peritoneal membrane function in children. Clinical journal of the American Society of Nephrology : CJASN, 2013, Volume: 8, Issue:1 Topics: Acid-Base Equilibrium; Acidosis; Adolescent; Bicarbonates; Body Water; Buffers; Child; Child, Presch	2013
Bicarbonate attenuates arterial desaturation during maximal exercise in humans. Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 93, Issue:2 Topics: Acidosis; Adult; Carbon Dioxide; Heart Rate; Humans; Hydrogen-Ion Concentration; Lactic Acid; Male;	2002
Adding lactate to the prime solution during hypothermic cardiopulmonary bypass: a quantitative acid-base analysis. British journal of anaesthesia, 2003, Volume: 90, Issue:4 Topics: Acid-Base Equilibrium; Acidosis; Adult; Aged; Aged, 80 and over; Cardiopulmonary Bypass; Double-Blin	2003
Conventional or physicochemical approach in intensive care unit patients with metabolic acidosis. Critical care (London, England), 2003, Volume: 7, Issue:3 Topics: Acid-Base Equilibrium; Acidosis; Adult; Aged; Aged, 80 and over; Anions; Blood Chemical Analysis; Ch	2003
Intensified exercise training does not alter AMPK signaling in human skeletal muscle. American journal of physiology. Endocrinology and metabolism, 2004, Volume: 286, Issue:5 Topics: Acetyl-CoA Carboxylase; Acidosis; Adult; AMP-Activated Protein Kinases; Analysis of Variance; Exerci	2004
Unidentified acids of strong prognostic significance in severe malaria. Critical care medicine, 2004, Volume: 32, Issue:8 Topics: Acid-Base Equilibrium; Acidosis; Adolescent; Adult; Aged; Cohort Studies; Creatinine; Critical Care;	2004
Metabolic acidosis developing during cardiopulmonary bypass is related to a decrease in strong ion difference. Perfusion, 2004, Volume: 19, Issue:3 Topics: Acid-Base Equilibrium; Acidosis; Aged; Cardioplegic Solutions; Cardiopulmonary Bypass; Hemodilution;	2004
Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial. Neurology, 2006, Jul-11, Volume: 67, Issue:1 Topics: Acidosis; Adolescent; Adult; Child; Cross-Over Studies; Dichloroacetic Acid; Double-Blind Method; Hu	2006
The effect of milrinone on metabolism after cardiopulmonary bypass. The Journal of cardiovascular surgery, 2008, Volume: 49, Issue:1 Topics: Acid-Base Equilibrium; Acidosis; Adult; Aged; Blood Glucose; Cardiac Surgical Procedures; Cardiopulm	2008
Treatment of pyruvic and lactic acidaemia in ophthalmoplegia plus. Advances in experimental medicine and biology, 1982, Volume: 153 Topics: Acidosis; Biopsy; Clinical Trials as Topic; Electromyography; Humans; Lactates; Lactic Acid; Microsc	1982
Effect of pH on sensation and vastus lateralis electromyogram during cycling exercise. Journal of applied physiology: respiratory, environmental and exercise physiology, 1982, Volume: 52, Issue:5 Topics: Acidosis; Adult; Alkalosis; Electromyography; Fatigue; Heart Rate; Humans; Hydrogen-Ion Concentratio	1982
Which bicarbonate concentration is adequate to lactate-buffered substitution fluids in maintenance hemofiltration? Clinical nephrology, 1994, Volume: 42, Issue:4 Topics: Acid-Base Equilibrium; Acidosis; Bicarbonates; Buffers; Cross-Over Studies; Female; Hemodialysis Sol	1994
Acidosis stimulates beta-endorphin release during exercise. Journal of applied physiology (Bethesda, Md. : 1985), 1994, Volume: 77, Issue:4 Topics: Acidosis; Adult; beta-Endorphin; Blood Gas Analysis; Buffers; Humans; Hydrogen-Ion Concentration; La	1994
The metabolic effects of surface cooling neonates prior to cardiac surgery. Anesthesia and analgesia, 1994, Volume: 79, Issue:5 Topics: Acidosis; Cardiac Surgical Procedures; Female; Fentanyl; Hemodynamics; Humans; Hypothermia, Induced;	1994
Traumatic brain tissue acidosis: experimental and clinical studies. Acta neurochirurgica. Supplementum, 1993, Volume: 57 Topics: Acid-Base Equilibrium; Acidosis; Animals; Blood-Brain Barrier; Brain Damage, Chronic; Head Injuries,	1993
Evaluation of oxygen availability with oxygen status algorithm in patients undergoing open heart surgery treated with epoetin beta. The Journal of laboratory and clinical medicine, 1997, Volume: 129, Issue:1 Topics: Acidosis; Algorithms; Cardiac Surgical Procedures; Double-Blind Method; Erythropoietin; Female; Huma	1997
Effects of blood pH and blood lactate on growth hormone, prolactin, and gonadotropin release after acute exercise in male volunteers. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1997, Volume: 214, Issue:2 Topics: Acidosis; Adult; Exercise; Follicle Stimulating Hormone; Gonadotropins; Growth Hormone; Hemodynamics	1997
Comparison of lactate and bicarbonate buffered haemofiltration fluids: use in critically ill patients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1997, Volume: 12, Issue:6 Topics: Acidosis; Adult; Bicarbonates; Buffers; Critical Illness; Hemofiltration; Humans; Lactic Acid; Prosp	1997
Sodium lactate and hypertonic sodium chloride induce equivalent panic incidence, panic symptoms, and hypernatremia in panic disorder. Biological psychiatry, 1998, Nov-15, Volume: 44, Issue:10 Topics: Acidosis; Adrenocorticotropic Hormone; Adult; Alkalosis; Arginine Vasopressin; Double-Blind Method;	1998
Sodium lactate as an alternative to sodium bicarbonate in the management of metabolic acidosis after pancreas transplantation. Transplantation, 1992, Volume: 53, Issue:1 Topics: Acidosis; Bicarbonates; Humans; Lactates; Lactic Acid; Pancreas Transplantation; Postoperative Compl	1992
Effect of respiratory alkalosis during exercise on blood lactate. Journal of applied physiology (Bethesda, Md. : 1985), 1986, Volume: 61, Issue:3 Topics: Acetazolamide; Acidosis; Adult; Alkalosis, Respiratory; Biofeedback, Psychology; Female; Humans; Hyd	1986

lactic acid and Acidosis