lactic acid has been researched along with Acidosis, Lactic in 631 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Acidosis, Lactic: Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as DIABETES MELLITUS; LEUKEMIA; or LIVER FAILURE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Moreover, MET-associated lactic acidosis (MALA) needs to be considered and the incidence of MALA in patients with type 2 DM-TB coinfection remains unknown." | 9.27 | A case risk study of lactic acidosis risk by metformin use in type 2 diabetes mellitus tuberculosis coinfection patients. ( Mertaniasih, NM; Novita, BD; Pranoto, A; Soediono, EI, 2018) |
| " However, if used in excessive doses for patients with kidney disease, it will be contraindicated with side effects such as lactic acidosis." | 9.22 | Lactic Acidosis Associated with Metformin in Patients with Diabetic Kidney Disease. ( Rahman, F; Tuba, S, 2022) |
| " However, no study has yet discovered which factor is most important for mortality in severe sepsis patients with lactic acidosis." | 9.20 | Lactate Clearance and Vasopressor Seem to Be Predictors for Mortality in Severe Sepsis Patients with Lactic Acidosis Supplementing Sodium Bicarbonate: A Retrospective Analysis. ( An, WS; Jeong, HJ; Kim, EB; Kim, SE; Lee, SM; Son, YK, 2015) |
| "To observe the therapeutic effect of early continuous blood purification (CBP) on lactic acidosis patients." | 9.17 | [Treatment of lactic acidosis with early continuous blood purification]. ( Cai, ZX; Chen, JP; Chen, WH; Fang, XB; Li, ZY; Wu, SW; Zhang, QC, 2013) |
| " Up to 40% of children with severe malarial anaemia have associated lactic acidosis." | 9.17 | The effect of blood storage age on treatment of lactic acidosis by transfusion in children with severe malarial anaemia: a pilot, randomized, controlled trial. ( Cserti-Gazdewich, CM; Dhabangi, A; Dzik, WH; Lubega, IR; Maganda, A; Mworozi, E, 2013) |
| " However, their ability to inhibit polymerase-γ has been associated with several mitochondrial toxicities, including potentially life-threatening lactic acidosis." | 9.16 | Risk factors for symptomatic hyperlactatemia and lactic acidosis among combination antiretroviral therapy-treated adults in Botswana: results from a clinical trial. ( Bussmann, H; D'Aquila, RT; DeGruttola, V; Eden, SK; Essex, M; Hendrickson, SL; Marlink, RG; Novitsky, V; O'Brien, SJ; Samuels, DC; Shepherd, BE; Wester, CW; Winkler, CA, 2012) |
| "The purpose of this research was to report results on long-term administration of dichloroacetate in 36 children with congenital lactic acidosis who participated previously in a controlled trial of this drug." | 9.13 | Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate. ( Carney, PR; Gilbert, LR; Neiberger, RE; Shuster, JJ; Stacpoole, PW; Theriaque, DW; Valenstein, E, 2008) |
| "To evaluate the role of chronic cerebral lactic acidosis in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)." | 9.11 | Cerebral lactic acidosis correlates with neurological impairment in MELAS. ( De Vivo, DC; DiMauro, S; Engelstad, K; Hirano, M; Jhung, S; Kaufmann, P; Mao, X; Mitsis, E; Sano, MC; Shanske, S; Shungu, DC, 2004) |
| "Our first objective was to determine a blood lactate threshold predictive of survival in human immunodeficiency virus patients experiencing lactic acidosis related to nucleoside analogs, and second, to test l-carnitine for the treatment of patients exceeding that threshold." | 9.10 | Detecting life-threatening lactic acidosis related to nucleoside-analog treatment of human immunodeficiency virus-infected patients, and treatment with L-carnitine. ( Azoulay, E; Branche, F; Cariou, A; Claessens, YE; Dhainaut, JF; Goldgran-Toledano, D; Monchi, M; Rouges, P; Soufir, L, 2003) |
| "To determine the influence of lactic acidosis, the Bohr effect, and exercise induced hyperkalaemia on the occurrence of the heart rate deflection point (HRDP) in elite (professional) cyclists." | 9.10 | Lactic acidosis, potassium, and the heart rate deflection point in professional road cyclists. ( Carvajal, A; Chicharro, JL; Hoyos, J; Lucía, A; Pérez, M; Santalla, A, 2002) |
| "Lactic acidosis frequently complicates severe malaria in African children, and is a strong independent predictor of mortality." | 9.08 | Pharmacokinetics and pharmacodynamics of dichloroacetate in children with lactic acidosis due to severe malaria. ( Agbenyega, T; Angus, BJ; Bedu-Addo, G; Henderson, G; Krishna, S; O'Brien, R; Ofori-Amanfo, G; Stacpoole, PW; Szwandt, IS, 1995) |
| " Lactic acidosis and hepatic dysfunction improved." | 9.08 | Intravenous almitrine bismesylate reversibly induces lactic acidosis and hepatic dysfunction in patients with acute lung injury. ( B'chir, A; Losser, MR; Mebazaa, A; Payen, D; Romieu, M, 1998) |
| "Marked lactic acidosis occurs during orthotopic liver transplantation (OLT), especially during the anhepatic phase." | 9.07 | Amelioration of lactic acidosis with dichloroacetate during liver transplantation in humans. ( Gallaher, EJ; Hromco, J; Robinson, ST; Shangraw, RE; Winter, R, 1994) |
| "To determine the pathogenesis and clinical course of lactic acidosis in adults receiving standard medical care." | 9.07 | Natural history and course of acquired lactic acidosis in adults. DCA-Lactic Acidosis Study Group. ( Baumgartner, TG; Bersin, RM; Buchalter, S; Curry, SH; Duncan, C; Harman, EM; Henderson, GN; Jenkinson, S; Stacpoole, PW; Wright, EC, 1994) |
| "L-lactic acidosis (L-LA) is the most common cause of metabolic acidosis in the critical care setting, which has been associated with a large increase in mortality." | 9.05 | L-lactic acidosis: pathophysiology, classification, and causes; emphasis on biochemical and metabolic basis. ( Halperin, ML; Kamel, KS; Oh, MS, 2020) |
| "Metformin-associated lactic acidosis (MALA) may occur after acute metformin overdose, or from therapeutic use in patients with renal compromise." | 9.05 | Do Patients Die with or from Metformin-Associated Lactic Acidosis (MALA)? Systematic Review and Meta-analysis of pH and Lactate as Predictors of Mortality in MALA. ( Benabbas, R; Blumenberg, A; Jeng, A; Sinert, R; Wiener, SW, 2020) |
| "Metformin-associated lactic acidosis (MALA) is a rare adverse effect that has significant morbidity and mortality." | 9.05 | Osmolar-gap in the setting of metformin-associated lactic acidosis: Case report and a literature review highlighting an apparently unusual association. ( Alamin, M; Elshafei, MN; Mohamed, MFH, 2020) |
| "D-lactic acidosis is an uncommon and challenging form of metabolic acidosis that may develop in short bowel syndrome." | 8.98 | D-lactic acidosis in humans: systematic literature review. ( Agostoni, C; Amelio, GS; Bianchetti, DGAM; Bianchetti, MG; Fossali, EF; Lava, SAG; Milani, GP; Simonetti, GD, 2018) |
| "Our main finding was that probiotics and fermented formulas did not cause d-lactic acidosis in healthy children." | 8.98 | Rapid review shows that probiotics and fermented infant formulas do not cause d-lactic acidosis in healthy children. ( Salminen, S; Szajewska, H; Łukasik, J, 2018) |
| " With serum lactate values > 10 mmol/l 80 % of the patients die in intensive care, and if the severe lactic acidosis persists for 48 hours, all patients die." | 8.98 | [Lactic acidosis - update 2018]. ( de Heer, G; Fuhrmann, V; Jarczak, D; Kluge, S; Nierhaus, A, 2018) |
| "The current practice concerning timing, mode, and dose of renal replacement therapy (RRT) in patients with metformin-associated lactic acidosis (MALA) with renal failure remains unknown." | 8.95 | Serum lactate level and mortality in metformin-associated lactic acidosis requiring renal replacement therapy: a systematic review of case reports and case series. ( Kuo, CC; Ting, IW; Tsai, CW; Wu, JY; Yeh, HC, 2017) |
| "Metformin-associated lactic acidosis (MALA) is a rare but potentially fatal condition that can easily be avoided." | 8.95 | [Metformin-associated lactic acidosis: an insufficiently recognised problem]. ( Bosch, FH; Kramers, C; Manders, M; van Luin, M, 2017) |
| "Type B lactic acidosis represents a rare and often lethal complication of haematological malignancy." | 8.91 | A case of type B lactic acidosis as a complication of chronic myelomonocytic leukaemia: a case report and review of the literature. ( Gardner, AJ; Griffiths, J, 2015) |
| " In each case, severe metabolic lactic acidosis was identified through routine laboratory diagnostics." | 8.91 | [Lactic acidosis in the postictal state]. ( Admiraal-van de Pas, Y; van Rooij, FJ, 2015) |
| " Metformin, however, is thought to increase the risk of lactic acidosis, and has been considered to be contraindicated in many chronic hypoxemic conditions that may be associated with lactic acidosis, such as cardiovascular, renal, hepatic and pulmonary disease, and advancing age." | 8.86 | Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. ( Greyber, E; Pasternak, GA; Salpeter Posthumous, EE; Salpeter, SR, 2010) |
| "Lactic acidosis is a common condition encountered by critical care providers." | 8.86 | Lactic acidosis: recognition, kinetics, and associated prognosis. ( Letourneau, JL; Vernon, C, 2010) |
| " Metformin, however, is thought to increase the risk of lactic acidosis, and has been considered to be contraindicated in many chronic hypoxemic conditions that may be associated with lactic acidosis, such as cardiovascular, renal, hepatic and pulmonary disease, and advancing age." | 8.86 | Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. ( Greyber, E; Pasternak, GA; Salpeter, EE; Salpeter, SR, 2010) |
| " During the past decade, however, evidence has accumulated that d-lactic acidosis is a more common occurrence in calves with neonatal diarrhoea." | 8.85 | D-Lactic acidosis in calves. ( Lorenz, I, 2009) |
| "Severe hyperlactataemia and lactic acidosis are rare serious complications of antiretroviral therapy (ART)." | 8.84 | Risk factors for lactic acidosis and severe hyperlactataemia in HIV-1-infected adults exposed to antiretroviral therapy. ( , 2007) |
| " NRTIs can induce mitochondrial impairment that leads to a number of adverse events, including symptomatic lactic acidosis." | 8.82 | Bench-to-bedside review: severe lactic acidosis in HIV patients treated with nucleoside analogue reverse transcriptase inhibitors. ( Cariou, A; Chiche, JD; Claessens, YE; Mira, JP, 2003) |
| "Nucleoside reverse-transcriptase inhibitors (NRTIs) have been associated with functional and structural mitochondrial abnormalities, leading to several adverse events, such as increased serum lactic acid levels and lactic acidosis." | 8.82 | Hyperlactataemia and lactic acidosis in HIV-infected patients receiving antiretroviral therapy. ( Calza, L; Chiodo, F; Manfredi, R, 2005) |
| "This report describes a case of d-lactic acidosis observed by the authors and then reviews all case reports of d-lactic acidosis in the literature in order to define its clinical and biochemical features and pathogenetic mechanisms." | 8.80 | D-lactic acidosis. A review of clinical presentation, biochemical features, and pathophysiologic mechanisms. ( Carroll, HJ; Oh, MS; Uribarri, J, 1998) |
| " D-Lactic acidosis was diagnosed on the basis of a D-lactate level of 8." | 8.80 | D-lactic acidosis: pathologic consequence of saprophytism. ( Farrugia, G; Vella, A, 1998) |
| "This article reviews the current body of knowledge regarding lactic acidosis in critically ill patients." | 8.78 | Lactic acidosis in critical illness. ( Falk, JL; Mizock, BA, 1992) |
| "A new patient with neonatal lactic acidosis due to pyruvate carboxylase deficiency is described." | 8.77 | [Neonatal lactic acidosis caused by severe pyruvate carboxylase deficiency]. ( Cortés Coto, MT; del Valle Martínez, J; García Aparicio, J; García Muñoz, MJ; Merinero Cortés, B; Pérez-Cerdá Silvestre, C; Sáez Pérez, E; Ugarte Pérez, M, 1988) |
| "Lactic acidosis is a clinical status related to clinical worsening." | 8.31 | Development of a prehospital lactic acidosis score for early-mortality. A prospective, multicenter, ambulance-based, cohort study. ( Castro Villamor, MA; Del Pozo Vegas, C; Delgado Benito, JF; López-Izquierdo, R; Martín-Conty, JL; Martín-Rodríguez, F; Ortega, GJ; Sanz-García, A, 2023) |
| "Lactic acidosis is a disease in which lactic acid accumulates in the blood and causes acidosis in the patient." | 8.31 | Metformin-associated severe lactic acidosis combined with multi-organ insufficiency induced by infection with Aeromonas veronii: A case report. ( Wu, C; Xia, Y; Zhu, X, 2023) |
| "Linezolid-induced lactic acidosis is a rare, but life-threatening complication of a commonly used drug." | 8.31 | Mitochondrial toxicity induced by linezolid causing lactic acidosis. ( Dass, J; Keri, VC; Kumar, TP; Mishra, RK; Sethi, P; Sharma, K, 2023) |
| "Lactic acidosis characterizes the tumor microenvironment (TME) and is involved in the mechanisms leading to cancer progression and dissemination through the reprogramming of tumor and local host cells (e." | 8.31 | Extracellular Lactic Acidosis of the Tumor Microenvironment Drives Adipocyte-to-Myofibroblast Transition Fueling the Generation of Cancer-Associated Fibroblasts. ( Andreucci, E; Biagioni, A; Calorini, L; Fioretto, BS; Manetti, M; Matucci-Cerinic, M; Romano, E; Rosa, I, 2023) |
| "Type B lactic acidosis is a rare but serious side effect of metformin use." | 8.31 | Treatment of severe metformin-associated lactic acidosis with renal replacement therapy and tris-hydroxymethyl aminomethane: a case report. ( Abdullin, M; Braden, GL; Hodgins, S; Landry, DL; Tiru, B; Yusim, D, 2023) |
| " LDHD mutations identified in patients with D-lactic acidosis lead to deficient LDHD activity." | 8.31 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. ( Chen, X; Ding, J; Jin, S; Yang, J, 2023) |
| "Splenic rupture followed by lactic acidosis and hypoglycaemia should lead to suspicion of a cancer-mediated Warburg effect, and prompt urgent chemotherapy." | 8.31 | B-cell hepatosplenic lymphoma presenting in adult patient after spontaneous splenic rupture followed by severe persistent hypoglycaemia: type B lactic acidosis and acute liver failure. ( Gude, MF; Hamilton-Dutoit, S; Moen, M; Steiniche, T, 2023) |
| " l-lactic acidosis, a common condition comprising high l-lactate concentration and acidic pH in the tumor microenvironment, has been known to induce tumor metastasis and drug resistance." | 8.12 | l-lactic acidosis confers insensitivity to PKC inhibitors by competing for uptake via monocarboxylate transporters. ( Chen, CH; Chen, CJ; Cheng, FJ; Chiou, JY; Huang, WC; Liu, YC; Nguyen, KTL; Shen, YC; Tang, CH; Tu, CY, 2022) |
| " The present study aims to evaluate the factors that may contribute to the decision whether to start RRT or not and the potential impact of the start of RRT on the outcome in patients with severe lactic acidosis (SLA) (lactate ≥5 mmol/L)." | 8.12 | Patients with Severe Lactic Acidosis in the Intensive Care Unit: A Retrospective Study of Contributing Factors and Impact of Renal Replacement Therapy. ( Hoste, EAJ; Kruse, JM; Van Biesen, W; Van De Ginste, L; Vanommeslaeghe, F; Verbeke, F, 2022) |
| "Type B lactic acidosis is a rare complication of non-tissue perfusion abnormalities caused by solid tumors or hematologic malignancies." | 8.12 | Type B lactic acidosis associated with diffuse large B-cell lymphoma and the Warburg effect. ( Lv, Z; Wang, C; Zhang, Y, 2022) |
| "The combination of propylene glycol ingestion and alcoholic ketoacidosis may have contributed to the severity of lactic acidosis." | 8.12 | Unexplained Metabolic Acidosis: Alcoholic Ketoacidosis or Propylene Glycol Toxicity. ( Boland, L; de Landsheere, F; Dewulf, JP; Dulaurent, S; Hantson, P; Haufroid, V; Laterre, PF; Saint-Marcoux, F, 2022) |
| "Background Lactic acidosis is associated with mortality in patients with cardiogenic shock (CS)." | 8.12 | Association Between the Acidemia, Lactic Acidosis, and Shock Severity With Outcomes in Patients With Cardiogenic Shock. ( Barsness, GW; Blankenberg, S; Holmes, DR; Jentzer, JC; Kashani, KB; Kirchhof, P; Patel, PC; Schrage, B; Westermann, D, 2022) |
| " The authors sought to provide evidence through a retrospective data analysis that helps investigate the relationship between intraoperative opioid dosage and postoperative lactic acidosis after cardiac surgery." | 8.12 | Sufentanil: a risk factor for lactic acidosis in patients after heart valve surgery. ( Ge, YP; Jiang, W; Luo, TG; Pan, YC; Shi, Q; Xiao, ZH; Zhan, YF; Zheng, BS, 2022) |
| " The case of an extremely premature infant with hyperglycemia and lactic acidosis associated with linezolid is reported." | 8.12 | Hyperglycemia and Lactic Acidosis Associated with Linezolid Therapy in an Extremely Premature Infant. ( Aoyama, M; Asai, S; Asai, T; Kakita, H; Mizuno, Y; Mori, M; Nakamura, N; Takeshita, S; Tomita, A; Ueda, H; Yamada, Y, 2022) |
| "Lactic acidosis, the extracellular accumulation of lactate and protons, is a consequence of increased glycolysis triggered by insufficient oxygen supply to tissues." | 8.02 | Acetoacetate protects macrophages from lactic acidosis-induced mitochondrial dysfunction by metabolic reprograming. ( Adam, C; Beauvillain, C; Blanchard, S; Delneste, Y; Gueguen, N; Jeannin, P; Le Mao, M; Mabilleau, G; Manero, F; Morel, A; Paolini, L; Pignon, P; Preisser, L; Procaccio, V; Reynier, P, 2021) |
| "D-lactic acidosis represents a rare form of metabolic acidosis that occurs most commonly in patients with short bowel syndrome." | 8.02 | D-lactic acidosis - a rare complication of short bowel syndrome. ( Majdák, P; Morgošová, S; Podušel, V; Sadloňová, J, 2021) |
| " Initial severe acidosis consisted of acute respiratory acidosis from ventilation-perfusion mismatch and acute metabolic acidosis resulting from bronchospasm and hypoxia-related lactic acidosis, respectively." | 8.02 | Salbutamol-induced lactic acidosis in status asthmaticus survivor. ( Boonkaya, S; Phoophiboon, V; Singhagowinta, P; Sriprasart, T, 2021) |
| "Metformin-associated lactic acidosis (MALA) is a widely documented adverse event of metformin." | 8.02 | The usefulness of measuring the anion gap in diagnosing metformin-associated lactic acidosis: a case series. ( Agra-Montava, I; Juanes-Borrego, A; Lozano-Polo, L; Mangues-Bafalluy, MA; Puig-Campmany, M; Ruiz-Ramos, J, 2021) |
| " We therefore hypothesised that lactic acidosis may confer resistance to Akt inhibition." | 7.96 | Lactic acidosis induces resistance to the pan-Akt inhibitor uprosertib in colon cancer cells. ( Aboagye, EO; Barnes, EME; Benito, A; Herendi, L; Keun, HC; Nijhuis, A; Siskos, AP; Xu, Y, 2020) |
| "Metformin-associated lactic acidosis (MALA) carries a high mortality rate." | 7.96 | Metformin-associated lactic acidosis: reinforcing learning points. ( Creagh, F; Goonoo, MS; Morris, R; Raithatha, A, 2020) |
| " We report three cases of prospectively identified laboratory confirmed metformin-associated lactic acidosis admitted to our intensive care unit." | 7.91 | Laboratory-Confirmed Metformin-Associated Lactic Acidosis ( Canavan, C; Coyle, N; Nasim, S; Nestor, C, 2019) |
| "This study aims to determine whether there is a relationship between nausea level and lactic acidosis during recovery from sprinting." | 7.91 | Role of lactic acidosis as a mediator of sprint-mediated nausea. ( Chivers, PT; Cripps, AJ; Fournier, PA; Merrells, RJ, 2019) |
| "To study the incidence of lactic acidosis due to metformin in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) stage 3-5." | 7.91 | Lactic acidosis due to metformin in type 2 diabetes mellitus and chronic kidney disease stage 3-5: is it significant? ( Guddattu, V; Mareddy, AS; Nagaraju, SP; Prabhu, RA; Rangaswamy, D, 2019) |
| " The primary outcomes were: (1) hyperlactatemia, defined as a lactate concentration ≥ 2 mmol/L at any point during hospital admission and, (2) metformin associated lactic acidosis (MALA), defined as a lactate concentration ≥ 5 mmol/L and pH <7." | 7.91 | Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose. ( Hoffman, RS; Manini, AF; Taub, ES, 2019) |
| "Gap acidosis except lactic acidosis developed and progressed during the CKD stage G5, while lactic acidosis developed in the CKD stages G1-4." | 7.91 | Gap acidosis except lactic acidosis develops and progresses during chronic kidney disease stage G5. ( Tanemoto, M, 2019) |
| "Metformin-associated lactic acidosis is a rare but serious complication of taking metformin." | 7.91 | Metformin-Associated Lactic Acidosis Presenting Like Acute Mesenteric Ischemia. ( Hastings, C; Johnson, K; Slaven, E; Zhang, QC, 2019) |
| "Pharmacokinetic data suggest that the risk of metformin-associated lactic acidosis (MALA) may be increased after Roux-en-Y gastric bypass (RYGB) surgery." | 7.88 | Risk of Metformin-Associated Lactic Acidosis (MALA) in Patients After Gastric Bypass Surgery. ( Aarts, EO; Aelfers, SCW; Berends, FJ; de Boer, H; Deden, LN; Janssen, IMC; van Borren, MMGJ, 2018) |
| "Lactic acidosis is a rare complication of linezolid (LZD) therapy, and its incidence and risk factors remain unknown." | 7.88 | Comparative analysis of lactic acidosis induced by linezolid and vancomycin therapy using cohort and case-control studies of incidence and associated risk factors. ( Aoki, Y; Bito, S; Hirose, S; Kamimura, Y; Kimura, Y; Mori, N, 2018) |
| " We describe 2 children with SBS who we believe are the second and third patients documented to have experienced both D-lactic acidosis and urolithiasis." | 7.88 | Stoned-A Syndrome of D-Lactic Acidosis and Urolithiasis. ( Berman, CM; Merritt, RJ, 2018) |
| "D-lactic acidosis is an infrequent complication, mainly reported in patients with short bowel syndrome." | 7.88 | [Dietetic treatment with fructose in a 5-year-old girl with recurrent D-lactic acidosis]. ( Pedrón Giner, C; Quijada Fraile, P; Travieso Suárez, L, 2018) |
| " D-lactic acidosis (D-LA) is a metabolic disorder that may occur in individuals with short bowel syndrome when lactate-producing bacteria in the colon overproduce D-lactate." | 7.88 | Intestinal Microbial and Metabolic Alterations Following Successful Fecal Microbiota Transplant for D-Lactic Acidosis. ( Bulik-Sullivan, EC; Carroll, IM; Elliott, RJ; Gulati, AS; Kassam, Z; Lichtman, SN; Roy, S, 2018) |
| " An increase of D-lactate-producing bacteria can lead to D-lactic acidosis, also referred to as D-lactate encephalopathy, with severe neurologic impairment." | 7.88 | D-lactic Acidosis: Successful Suppression of D-lactate-Producing ( Macpherson, AJ; Schibli, S; Sokollik, C; Yilmaz, B, 2018) |
| "Lactic acidosis in the emergency department and other hospital settings is typically due to tissue hypoxia with sepsis being the most common cause." | 7.88 | Lactic Acidosis in a Critically Ill Patient: Not Always Sepsis. ( Leger, KJ; Schuh, AM; Summers, C; Uspal, NG, 2018) |
| " Plasmodium falciparum infection can cause severe malaria anaemia (SMA) with insufficient tissue oxygenation, lactic acidosis and death." | 7.88 | Mitochondrial gene sequence variants in children with severe malaria anaemia with or without lactic acidosis: a case control study. ( Amr, SS; Cserti-Gazdewich, C; Dhabangi, A; Dzik, W; Fowler, C; Musoke, C; Sharma, H, 2018) |
| "Metformin is renally excreted and has been associated with the development of lactic acidosis." | 7.85 | Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study. ( Connelly, PJ; Donnelly, L; Lonergan, M; Pearson, ER; Soto-Pedre, E; Zhou, K, 2017) |
| "Chronic metformin treatment mildly increases lactate level, but does not induce hyperlactatemia or lactic acidosis in acute illness on the first day of admission to an internal medicine ward." | 7.85 | Metformin Does Not Induce Hyperlactatemia in Patients Admitted to Internal Medicine Ward. ( Doenyas-Barak, K; Golik, A; Koren, R; Koren, S; Zilberman-Itskovich, S, 2017) |
| "Lactic acidosis represents the pathologic accumulation of lactate and hydrogen ions." | 7.85 | Low sensitivity of anion gap to detect clinically significant lactic acidosis in the emergency department. ( Cembrowski, GS; Fuezery, A; HowlettClyne, S; Xu, Q, 2017) |
| "To investigate the effect of lactic acidosis on the survival of Lewis lung carcinoma cells under glucose-deprived conditions." | 7.85 | Impact of lactic acidosis on the survival of Lewis lung carcinoma cells. ( Kolesnik, DL; Pyaskovskaya, ON; Solyanik, GI, 2017) |
| "D-lactic acidosis can occur in patients with short bowel syndrome (SBS) when excessive malabsorbed carbohydrate (CHO) enters the colon and is metabolized by colonic bacteria to D-lactate." | 7.85 | Fecal Transplantation Successfully Treats Recurrent D-Lactic Acidosis in a Child With Short Bowel Syndrome. ( Davidovics, ZH; Etienne, N; Hyams, JS; Vance, K, 2017) |
| " There was no difference in prevalence of hyperlactatemia and lactic acidosis between the patients with and without metformin use (18." | 7.85 | Association between Metformin Use and Risk of Lactic Acidosis or Elevated Lactate Concentration in Type 2 Diabetes. ( Cha, BS; Han, E; Hwang, S; Kang, ES; Kang, HP; Lee, BW; Lee, EY; Lee, HC; Lee, SH; Lee, W; Lee, YH; Lee, YM, 2017) |
| "The role of metformin in lactic acidosis is regularly questioned." | 7.83 | Lactic acidosis: relationship between metformin levels, lactate concentration and mortality. ( Altman, JJ; Boucaud-Maitre, D; Bouhanick, B; Doucet, J; Emmerich, J; Girardin, E; Kaloustian, E; Lassmann Vague, V; Porokhov, B; Ropers, J, 2016) |
| "To evaluate the strength of association between lactic acidosis (LA) and well-recognized risk factors for LA, particularly the weight of metformin." | 7.83 | Lactic Acidosis in Diabetic Population: Is Metformin Implicated? Results of a Matched Case-Control Study Performed on the Type 2 Diabetes Population of Grenoble Hospital University. ( Chanoine, S; Giai, J; Lepelley, M; Villier, C; Yahiaoui, N, 2016) |
| "We report a case of metformin-associated lactic acidosis (MALA) in the setting of normal renal function and review the relevant medical literature." | 7.83 | Metformin-Associated Lactic Acidosis in a Patient with Normal Renal Function. ( Ellen, R; Omar, A; Sorisky, A, 2016) |
| " Our previous works suggested that cancer cells reverted to OXPHOS, when they were exposed to lactic acidosis, a common factor in tumor environment." | 7.83 | Lactic acidosis switches cancer cells from aerobic glycolysis back to dominant oxidative phosphorylation. ( Hu, X; Wu, H; Ying, M, 2016) |
| "Lactic acidosis is common in critical care; by contrast, a subtype called alcohol-associated lactic acidosis (AALA) is rarely encountered." | 7.83 | Prognosis of alcohol-associated lactic acidosis in critically ill patients: an 8-year study. ( Chan, KS; Tseng, KL; Weng, SF; Yang, CC, 2016) |
| "Lactic acidosis (LA) frequently occurs after heart transplantation (HTx)." | 7.81 | Lactic acidosis after cardiac transplantation: foe or common innocent bystander? ( Alharethi, R; Bair, T; Balling, KD; Brunisholz, K; Budge, D; Doty, J; Goddard, M; Kfoury, AG; McCubrey, R; Nixon, JL; Rasmusson, B; Reid, B; Smith, H; Thomsen, G, 2015) |
| "The March 2012 regulatory action issued by the Japanese government signalled the rare but serious complication of lactic acidosis that can occur during metformin treatment, especially with the high dose formulation, h-metformin, and in those above 75 years old." | 7.81 | Impact of Japanese regulatory action on metformin-associated lactic acidosis in type II diabetes patients. ( Hanatani, T; Sai, K; Saito, Y; Segawa, K; Tohkin, M, 2015) |
| "Metformin-induced lactic acidosis is a rare but severe disease for the individual patients." | 7.81 | [Metformin-induced lactic acidosis : Severe symptoms with difficult diagnostics]. ( Brenner, T; Decker, SO; Hofer, S; Siegler, BH; Ulrich, A; Wortmann, M, 2015) |
| "Thiamine functions as an important cofactor in aerobic metabolism and thiamine deficiency can contribute to lactic acidosis." | 7.80 | The relationship between lactate and thiamine levels in patients with diabetic ketoacidosis. ( Berg, K; Donnino, MW; Gautam, S; Giberson, T; Graver, A; Liu, X; Moskowitz, A; Uber, A, 2014) |
| " All cases of lactic acidosis (pH, ≤ 7." | 7.80 | Metformin accumulation: lactic acidosis and high plasmatic metformin levels in a retrospective case series of 66 patients on chronic therapy. ( Giampreti, A; Locatelli, CA; Lonati, D; Manzo, L; Papa, P; Petrolini, VM; Protti, A; Rocchi, L; Rognoni, C; Rolandi, L; Valli, A; Vecchio, S, 2014) |
| "The relative desirable lactate imprecision for patients with lactic acidosis is about half that of normal individuals." | 7.80 | Tighter precision target required for lactate testing in patients with lactic acidosis. ( Cembrowski, GS; Chin, D; Holmes, D; Kunst, AN; Redel, S; Rimkus, M; Tran, D; Versluys, KA, 2014) |
| "Severe lactic acidosis (SLA) is frequent in intensive care unit (ICU) patients with acute kidney injury (AKI) treated with renal replacement therapy (RRT)." | 7.80 | Severe lactic acidosis in critically ill patients with acute kidney injury treated with renal replacement therapy. ( De Corte, W; De Waele, JJ; Decruyenaere, J; Dhondt, AW; Hoste, EA; Vanholder, R; Vuylsteke, S, 2014) |
| "The objective of this study was to determine whether treatment with metformin in patients with renal impairment is associated with a higher risk of lactic acidosis or elevated lactate concentrations compared with users of a noninsulin antidiabetic drug (NIAD) who had never used metformin." | 7.80 | Risk of lactic acidosis or elevated lactate concentrations in metformin users with renal impairment: a population-based cohort study. ( De Smet, PA; de Vries, F; Derijks, HJ; Egberts, A; Eppenga, WL; Geerts, AF; Lalmohamed, A; Wensing, M, 2014) |
| "A 16-year-old perioperative paediatric patient presented with refractory lactic acidosis and multiorgan failure due to thiamine-deficient total parenteral nutrition during a recent national multivitamin shortage." | 7.80 | Severe lactic acidosis and multiorgan failure due to thiamine deficiency during total parenteral nutrition. ( Hartman, G; Mowbray, C; Pageler, N; Ramsi, M, 2014) |
| " Several patients with lactic acidosis and glucose levels below 1." | 7.80 | A patient with acute liver failure and extreme hypoglycaemia with lactic acidosis who was not in a coma: causes and consequences of lactate-protected hypoglycaemia. ( Gladden, LB; Goodwin, ML; McDonald, JR; Nijsten, MW; Oldenbeuving, G; Reijngoud, DJ; Sayilir, R, 2014) |
| "There is controversy surrounding the risk of metformin and the development of lactic acidosis." | 7.80 | Pharmacist review prevents evolving metformin-associated lactic acidosis. ( Kyle, G; Naunton, M; Naunton-Boom, K; Owoka, F, 2014) |
| "Lactic acidosis occurs in a number of clinical conditions, e." | 7.80 | Lactic acidosis treatment by nanomole level of spermidine in an animal model. ( Mirkhani, H; Sahmeddini, MA; Sattarahmady, N; Sedigh-Ardekani, M, 2014) |
| "Lactic acidosis is an adverse event associated with metformin usage." | 7.79 | The Role of Metformin in Metformin-Associated Lactic Acidosis (MALA): Case Series and Formulation of a Model of Pathogenesis. ( Day, RO; Duong, JK; Furlong, TJ; Graham, GG; Greenfield, JR; Roberts, DM; Williams, KM, 2013) |
| " We conclude that chronic DCA administration is generally well-tolerated in patients with congenital causes of lactic acidosis and is effective in maintaining normal blood lactate levels, even in PDC-deficient children not consuming strict ketogenic diets." | 7.79 | Long-term safety of dichloroacetate in congenital lactic acidosis. ( Abdelmalak, M; Coats, BS; Langaee, T; Lew, A; Neiberger, RE; Ramezani, R; Shankar, MN; Shroads, AL; Stacpoole, PW; Subramony, SH, 2013) |
| "Lactic acidosis is a life-threatening complication of hemorrhagic shock." | 7.79 | Pyruvate Ringer's solution corrects lactic acidosis and prolongs survival during hemorrhagic shock in rats. ( Bai, XD; Fang, T; Hu, S; Liu, XQ; Wang, HB; Zhong, YX; Zhou, FQ, 2013) |
| "Hyperlactatemia and lactic acidosis are common in adults with acute severe asthma however only a few cases have been reported in children." | 7.78 | Mechanism of lactic acidosis in children with acute severe asthma. ( McCaulley, L; Meert, KL; Sarnaik, AP, 2012) |
| "Lactic acidosis is common to most solid tumors and has been found to affect infiltrating immune cells." | 7.78 | Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation. ( Gottfried, E; Hu, B; Kreutz, M; Mendler, AN; Noessner, E; Prinz, PU, 2012) |
| " Metformin-associated lactic acidosis may sometimes be life-threatening." | 7.78 | Metformin-associated lactic acidosis following acute kidney injury. Efficacious treatment with continuous renal replacement therapy. ( Dahan, E; Dichtwald, S; Ekstein, MP; Sorkine, P; Weinbroum, AA, 2012) |
| "Lactic acidosis is a fatal adverse effect of metformin, but the risk factor remains unclear." | 7.78 | Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis. ( Fujimoto, S; Hosokawa, M; Inagaki, N; Inui, K; Katsura, T; Masuda, S; Osawa, R; Toyama, K; Yonezawa, A, 2012) |
| "Hyperlactatemia and lactic acidosis (LA) are among the most dangerous and life-threatening side effect that occurs during therapy with some nucleoside reverse transcriptase inhibitors (NRTIs), mainly didanosine (ddI) and stavudine (d4T), also known as d-drugs." | 7.78 | The role of nucleoside reverse transcriptase inhibitors usage in the incidence of hyperlactatemia and lactic acidosis in HIV/AIDS patients. ( Dragovic, G; Jevtovic, D, 2012) |
| "Genetic factors play a role in the development of lactic acidosis after OLT." | 7.78 | The association of promoter gene polymorphisms of the tumor necrosis factor-α and interleukin-10 with severity of lactic acidosis during liver transplantation surgery. ( Abouelfetoh, F; Baz, H; Farahat, O; Labib, D; Mokhtar, A; Salah, M, 2012) |
| "Lactic acidosis in the absence of hypoxia or tissue hypoperfusion (type B) is very rare and is associated with the use of some drugs or malignancy." | 7.78 | [Type B lactic acidosis associated with marginal lymphoma of the spleen: report of one case]. ( Peña, A; Rodríguez, Mde L; Vásquez, A; Vega, J, 2012) |
| "The aim was to investigate whether the level of lactic acidosis in the first part of a heart rate-based lactate minimum test affects the lactate minimum heart rate and performance." | 7.78 | The level of lactic acidosis affects lactate minimum in a heart rate-based lactate minimum test. ( Labruyère, R; Perret, C, 2012) |
| "Literature review of cases of lymphoma with lactic acidosis, with and without hypoglycemia, demonstrated that these combinations occurred in multiple categories of B- and T-cell lymphoma." | 7.78 | "Hyper-warburgism," a cause of asymptomatic hypoglycemia with lactic acidosis in a patient with non-Hodgkin's lymphoma. ( Albert, SG; Elhomsy, GC; Eranki, V; Fesler, MJ; Griffing, GT; Michael, AG; Parker, SM, 2012) |
| " Laboratory findings showed hypokalemia, hypophosphatemia, and lactic acidosis." | 7.78 | Lactic acidosis following intentional overdose by inhalation of salmeterol and fluticasone. ( Hantson, P; Manara, A; Thys, F; Vanpee, D, 2012) |
| "Metformin has long been thought to cause lactic acidosis (LA) but evidence from various sources has led researchers to question a direct causative relationship." | 7.77 | Diabetes, metformin and lactic acidosis. ( Harvey, JN; Scale, T, 2011) |
| " In contrast, in Himalayan marmots treated with AZT we observed delayed toxicity, including lactic acidosis, severe hepatic steatosis, obvious mitochondrial damage, and significant decreases in respiratory chain complex enzyme activity and mtDNA content." | 7.77 | Evaluation of mitochondrial toxicity in Marmota himalayana treated with metacavir, a novel 2',3'-dideoxyguanosine prodrug for treatment of hepatitis B Virus. ( Chen, H; Hu, M; Jiang, Z; Li, Z; Tao, Y; Xiong, Y; Zhang, L; Zhang, P, 2011) |
| " Two cases of lactic acidosis due to ingestion of high dose metformin for suicidal purposes have been presented here; in both cases, clinical improvement was seen with bicarbonate hemodialysis." | 7.77 | Dialysis therapy for lactic acidosis caused by metformin intoxication: presentation of two cases. ( Aytemiz, E; Begenik, H; Emre, H; Erkoc, R; Ozturk, M; Soyoral, YU, 2011) |
| "Lactic acidosis (LA) and severe hyperlactataemia (HL) are infrequent but serious complications of antiretroviral therapy that have been associated with a high fatality rate." | 7.77 | Risk factors for fatality in HIV-infected patients with dideoxynucleoside-induced severe hyperlactataemia or lactic acidosis. ( Arenas-Pinto, A; Bhaskaran, K; Carr, A; Copas, A; Dunn, D; Grant, A; Hoy, J; Martinez, E; Reiss, P; Weber, R; Weller, I; Worm, SW, 2011) |
| " The use of zidovudine instead of stavudine in higher-risk patients to reduce the likelihood of lactic acidosis and hyperlactatemia (LAHL) has not been examined." | 7.77 | A risk-factor guided approach to reducing lactic acidosis and hyperlactatemia in patients on antiretroviral therapy. ( Axten, K; Bangsberg, DR; Carver, E; Ewusi, A; Gandhi, RT; Geary, MC; Ghebremichael, M; Giddy, J; Guarino, AJ; Hampton, J; Matthews, LT, 2011) |
| "The reported incidence of metformin associated lactic acidosis (MALA) in type 2 diabetes mellitus (DM) is 3-9 cases per 100,000 patient-years." | 7.77 | Metformin associated lactic acidosis: incidence and clinical correlation with metformin serum concentration measurements. ( Doorenbos, CJ; van Berlo-van de Laar, IR; Vermeij, CG, 2011) |
| " His case was reviewed, and the lactic acidosis was thought to be caused by inhaled β2-agonist use." | 7.77 | Take my breath away: a case of lactic acidosis in an asthma exacerbation. ( McGonigle, R; Woods, RA, 2011) |
| "Linezolid administration has been associated with lactic acidosis in adults; however, the same phenomenon has not been reported in children." | 7.77 | Linezolid and lactic acidosis: a role for lactate monitoring with long-term linezolid use in children. ( Carcillo, JA; Crowley, K; Michaels, MG; Su, E, 2011) |
| " This agreement between glycolytic H+ production and elevation of lactate is confirmed by an analysis of the underlying reactions involved in glycolysis in vivo and supports the concept of lactic acidosis under conditions that substantially elevate lactate and drop pH." | 7.76 | Lactic acidosis in vivo: testing the link between lactate generation and H+ accumulation in ischemic mouse muscle. ( Conley, KE; Kushmerick, MJ; Marcinek, DJ, 2010) |
| "Diaspirin cross-linked hemoglobin (DCLHb) has demonstrated a pressor effect that could adversely affect traumatic hemorrhagic shock patients through diminished perfusion to vital organs, causing base deficit (BD) and lactate abnormalities." | 7.76 | Diaspirin cross-linked hemoglobin infusion did not influence base deficit and lactic acid levels in two clinical trials of traumatic hemorrhagic shock patient resuscitation. ( Gao, W; Koenigsberg, MD; Philbin, NB; Sloan, EP, 2010) |
| "Lactic acidosis has been considered to be a side effect of some biguanides, after phenformin was withdrawn from the market because of its association with lactic acidosis." | 7.76 | Comparison of potential risks of lactic acidosis induction by biguanides in rats. ( Bando, K; Deguchi, J; Funabashi, H; Kimura, J; Kunimatsu, T; Ochiai, S; Seki, T, 2010) |
| "Lactic acidosis causes atrial fibrillation (AF), and pulmonary veins (PVs) are the most important focus for the generation of AF." | 7.75 | Cariporide (HOE642) attenuates lactic acidosis induced pulmonary vein arrhythmogenesis. ( Chen, SA; Chen, YC; Chen, YJ; Cheng, CC; Higa, S; Udyavar, AR, 2009) |
| "To compare the prognostic abilities of lactic acidosis and hyperlactatemia and determine the influence of metabolic acidosis when attempting to predict the outcome of septic patients using serum lactate levels." | 7.74 | Lactic acidosis not hyperlactatemia as a predictor of in hospital mortality in septic emergency patients. ( Baek, KJ; Choi, SH; Hong, YS; Kim, JY; Lee, SW; Moon, SW; Park, DW; Park, JS, 2008) |
| "Lactic acidosis is an integral index of metabolic disturbances and severity of inflammation processes." | 7.74 | [Clinical implications of lactic acidosis in purulent meningitis]. ( Chentsov, VB; Menushenkova, SA; Migmanov, TE; Molotilova, TN; Nagibina, MV; Vengerov, IuIa, 2008) |
| "To determine whether lactic acidosis at birth in asphyxiated neonates could predict the grade of EEG encephalopathy by examining the relationship between time taken for the normalisation of lactate, severity of encephalopathy and seizure burden." | 7.74 | Persistent lactic acidosis in neonatal hypoxic-ischaemic encephalopathy correlates with EEG grade and electrographic seizure burden. ( Boylan, GB; Connolly, S; Fitzgerald, AP; Murphy, BP; Murray, DM; Ryan, CA, 2008) |
| "Although the blood lactate-to-pyruvate (L:P) molar ratio is used to distinguish between pyruvate dehydrogenase deficiency (PDH-D) and other causes of congenital lactic acidosis (CLA), its diagnostic accuracy for differentiating between these 2 types of CLA has not been evaluated formally." | 7.74 | Diagnostic accuracy of blood lactate-to-pyruvate molar ratio in the differential diagnosis of congenital lactic acidosis. ( Allard, P; Debray, FG; Hanley, JA; Lambert, M; Mitchell, GA; Robinson, BH, 2007) |
| " Measurement of pH in cerebrospinal fluid (CSF) yielded central lactic acidosis despite alkalosis in peripheral blood." | 7.74 | Central lactic acidosis, hyperventilation, and respiratory alkalosis: leading clinical features in a 3-year-old boy with malignant meningeal melanoma. ( Bierbach, U; Blüher, S; Hirsch, W; Kiess, W; Meixensberger, J; Schober, R; Schulz, M; Siekmeyer, W; Tröbs, RB, 2008) |
| " Lactic acidosis is a clinically important metabolic condition accompanying various tissue disorders in which the extracellular pH and the intracellular pH often change in parallel." | 7.74 | Early and late activation of the voltage-gated proton channel during lactic acidosis through pH-dependent and -independent mechanisms. ( Kawawaki, J; Kuno, M; Morihata, H; Notomi, T; Okina, M; Sakai, H; Sawada, M, 2008) |
| "This study demonstrates that exogenous ADM prevents and reverses hypodynamic circulation, attenuates pulmonary hypertension, and limits lactic acidosis in ovine endotoxaemia." | 7.74 | Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia. ( Booke, M; Ertmer, C; Hucklenbruch, C; Lange, M; Morelli, A; Rehberg, S; Van Aken, H; Westphal, M, 2007) |
| "d-lactic acidosis is a rare and severe complication of short bowel syndrome in children that may result from important ileal bacterial overgrowth by lactobacilli." | 7.74 | [D-lactic acidosis in a child with short bowel syndrome]. ( Dahhak, S; Fontaine, M; Gottrand, F; Mention, K; Michaud, L; Romond, MB; Turck, D; Uhlen, S, 2008) |
| "Mitochondrial myopathies are heterogeneous disorders with diverse presentations including laboratory findings of lactic acidosis." | 7.74 | Severe lactic acidosis secondary to minocycline in a teenager with infectious mononucleosis and mitochondrial myopathy. ( Rison, RA; Zoraster, RM, 2008) |
| "We intended to find out the effectiveness of lactic acidosis therapy for mitochondrial toxicity." | 7.73 | [Treatment of symptomatic hyperlactatemia and lactic acidosis in HIV+ patients under nucleoside reverse transcriptase inhibitors]. ( Deig, E; Garrabou, G; Miró, O; Pedrol, E; Ribell, M; Soler, A; Villà, Mdel C, 2005) |
| " Caenorhabditis elegans strains with complex I mutations exhibit characteristic features of human mitochondrial disease including decreased rates of respiration and lactic acidosis." | 7.73 | Introduction of an additional pathway for lactate oxidation in the treatment of lactic acidosis and mitochondrial dysfunction in Caenorhabditis elegans. ( Grad, LI; Lemire, BD; Sayles, LC, 2005) |
| "Lactic acidosis portends a poor prognosis in trauma, sepsis, and other shock states and is useful for triaging and resuscitating emergency department (ED) patients." | 7.73 | The anion gap does not accurately screen for lactic acidosis in emergency department patients. ( Adams, BD; Bonzani, TA; Hunter, CJ, 2006) |
| " D-lactic acidosis was diagnosed on the basis of a D-lactate level of 5." | 7.72 | D-lactic acidosis secondary to short bowel syndrome. ( Cao, B; Jiang, J; Jiang, ZW; Li, JS; Zhang, DL, 2003) |
| "Biguanides are a class of drugs widely used as oral antihyperglycemic agents for the treatment of type 2 diabetes mellitus, but they are associated with lactic acidosis, a lethal side effect." | 7.72 | Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin. ( Jonker, JW; Kato, Y; Kusuhara, H; Schinkel, AH; Sugiyama, Y; Wang, DS, 2003) |
| "Lactic acidosis has been reported as a complication associated with antiretroviral therapy; in particular, usually with use of nucleoside reverse-transcriptase inhibitors." | 7.72 | Human immunodeficiency virus infection with human granulocytic ehrlichiosis complicated by symptomatic lactic acidosis. ( Altice, FL; Springer, SA, 2003) |
| "In type II diabetes treated with metformin, lactic acidosis is a rare but severe complication." | 7.72 | [Metformin-associated lactic acidosis precipitated by acute renal failure]. ( Azoulay, E; Galy-Floc'h, M; Mariot, J; Pertek, JP; Vidal, S, 2003) |
| "We report 4 cases of lactic acidosis in diabetic patients usually treated with metformin." | 7.72 | [Metformin-associated lactic acidosis remains a serious complication of metformin therapy]. ( Giunti, C; Grimaud, D; Ichai, C; Levraut, J; Orban, JC, 2003) |
| "We describe the case of a 7-year-old boy with osteogenesis imperfecta, who underwent anaesthesia with propofol-fentanyl-nitrous oxide-suxamethonium for orthopaedic surgery of a distal femur fracture." | 7.72 | Lacticacidosis after short-term infusion of propofol for anaesthesia in a child with osteogenesis imperfecta. ( Kill, C; Leonhardt, A; Wulf, H, 2003) |
| "An 11-month-old girl with B-cell leukemia/lymphoma developed profound lethargy due to severe lactic acidosis during chemotherapy and total parenteral nutrition (TPN)." | 7.72 | Severe lactic acidosis due to thiamine deficiency in a patient with B-cell leukemia/lymphoma on total parenteral nutrition during high-dose methotrexate therapy. ( Calvillo, M; Caruso, U; Dufour, C; Minniti, G; Schiaffino, MC; Svahn, J, 2003) |
| "Lactic acidosis is a rare but potentially life-threatening and poorly understood sequelae among HIV-infected patients on highly active antiretroviral therapy (HAART)." | 7.72 | Highly active antiretroviral therapy (HAART)-associated lactic acidosis: in vitro effects of combination of nucleoside analogues and protease inhibitors on mitochondrial function and lactic acid production. ( Frank, JE; Nerurkar, PV; Nerurkar, VR; Pearson, L; Yanagihara, R, 2003) |
| "Myometrial lactic acidosis and a small decrease in O(2) saturation may be contributing factors to dysfunctional labor." | 7.72 | Dysfunctional labor and myometrial lactic acidosis. ( Brigham, S; Pierce, SJ; Quenby, S; Wray, S, 2004) |
| "Lactic acidosis is a life-threatening complication of antiretroviral therapy with an incidence of about 1% per year." | 7.72 | [Lactic acidosis in HIV-patients--diagnosis and treatment]. ( Walker, UA, 2004) |
| " Initial investigations demonstrated a severe lactic acidosis." | 7.72 | Severe lactic acidosis following alcohol related generalised seizures. ( Hulme, J; Sherwood, N, 2004) |
| "To evaluate the prevalence, outcome and possible risk factors for hyperlactataemia and lactic acidosis in HIV-positive persons receiving antiretroviral therapy." | 7.71 | Hyperlactataemia and lactic acidosis during antiretroviral therapy: relevance, reproducibility and possible risk factors. ( Asboe, D; Datta, D; Gazzard, BG; Mandalia, S; Morlese, J; Moyle, GJ, 2002) |
| "Type B lactic acidosis is rare among patients with malignant diseases." | 7.71 | Multiple myeloma associated with lactic acidosis. ( Burgess, R; Dainer, P; Fall, P; Hendricks, L; Jillella, A; Szerlip, HM; Ustun, C, 2002) |
| "Dobutamine increased resting O(2) and O(2) at the lactic acidosis threshold (LAT) but not peak O(2)." | 7.71 | Effects of dobutamine on critical capillary PO(2) and lactic acidosis threshold in patients with cardiovascular disease. ( Adachi, H; Hiroe, M; Itoh, H; Kobayashi, K; Koike, A; Shimizu, N; Wasserman, K, 2001) |
| "Lactic acidosis (LAc) is a common form of metabolic acidosis early after heart transplantation (HTX)." | 7.71 | Lactic acidosis following heart transplantation: a common phenomenon? ( Carrel, T; Hullin, R; Mohacsi, P; Pedrazzinia, G; Tanner, H; Tschanz, HU, 2002) |
| " Lactic acidosis is exceptionally associated to this allergy." | 7.70 | [Severe lactic acidosis disease disclosing milk-protein intolerance to cows' milk]. ( Ogier de Baulny, H; Olivier, C; Rizk, C; Saudubray, JM; Valdes, L, 1999) |
| "The antidiabetic drug metformin has been associated in a small number of patients with lactic acidosis, a serious condition with a poor prognosis." | 7.70 | Lactic acidosis in metformin-treated patients. Prognostic value of arterial lactate levels and plasma metformin concentrations. ( Lalau, JD; Race, JM, 1999) |
| "Hemorrhagic shock is associated with lactic acidosis and increased plasma catecholamines." | 7.70 | Adrenergic antagonists reduce lactic acidosis in response to hemorrhagic shock. ( Frame, SB; Friend, LA; James, JH; Luchette, FA; McCarter, F; Robinson, BR, 1999) |
| "The present study was designed to investigate the efficacy of control of lactic acidosis by immunisation against lactic acid-producing bacteria, Streptococcus bovis and Lactobacillus." | 7.70 | Immunisation against lactic acidosis in cattle. ( Bird, SH; Gill, HS; Hennessy, DW; Leng, RA; Rowe, JB; Shu, Q, 1999) |
| "Oxidative phosphorylation of isolated rat skeletal muscle mitochondria after exposure to lactic acidosis in either phosphorylating or nonphosphorylating states has been evaluated." | 7.70 | Actively phosphorylating mitochondria are more resistant to lactic acidosis than inactive mitochondria. ( Sahlin, K; Tonkonogi, M, 1999) |
| "The biguanide drugs metformin and phenformin have been linked in the past to lactic acidosis, a metabolic condition associated with high rates of mortality." | 7.70 | Lactic acidosis in metformin therapy. ( Lalau, JD; Race, JM, 1999) |
| "In septic shock, the extent to which lactic acidosis (LA) is a consequence of splanchnic lactate overproduction (SLP) or impaired hepatic lactate extraction (HLE) is not clear." | 7.70 | Impaired hepatic extraction and increased splanchnic production contribute to lactic acidosis in canine sepsis. ( Bands, C; Bautista, E; Bose, D; Chrusch, C; Duke, K; Eschun, G; Jacobs, H; Li, X; Light, RB; Mink, SN, 2000) |
| "Microbial and fermentation changes in the ingesta of the large intestine and their influence on the pathogenesis of acute lactic acidosis were studied in 4 cows fitted with permanent cannulas in the ileum and cecum." | 7.70 | [Impact of lactic acid fermentation in the large intestine on acute lactic acidosis in cattle]. ( Pestevsek, U; Vengust, A; Zust, J, 2000) |
| " Lactic acidosis induced by exercise increases the stress on the ventilatory system due to CO2 generated by bicarbonate buffering and hydrogen ion stimulation." | 7.69 | Contribution of the respiratory muscles to the lactic acidosis of heavy exercise in COPD. ( Carithers, E; Casaburi, R; Engelen, MP; Rucker, R, 1995) |
| "D-Lactic acidosis is an unique complication of jejunoileal bypass occurring because of alteration of colonic bacterial flora with selective proliferation of D-lactate-producing bacteria." | 7.69 | D-lactic acidosis in a patient with jejunoileal bypass. ( Kadakia, SC, 1995) |
| "Ethanol intoxication has been widely reported as a cause of lactic acidosis." | 7.69 | Lactic acidosis and acute ethanol intoxication. ( Kruse, JA; Levy, DB; MacDonald, L; Marulendra, S; Sweeny, PJ, 1994) |
| "A hemodialysed patient with abdominal pain, severe lactic acidosis and prolonged hypoglycemia is described." | 7.69 | Acute necrotizing pancreatitis, lactic acidosis and prolonged hypoglycemia in a hemodialysed patient--a logical but unfortunately fatal combination. ( Chagnac, A; Gafter, U; Halperin, M; Korzets, A; Ori, Y; Weinstein, T; Zevin, D, 1996) |
| "Previously, we have demonstrated that short bowel syndrome (SBS) patients suffer daily from D-lactic acidemia; in these patients rather high amounts of (bacterial) D-lactate emerge in blood and urine with a circadian rhythm." | 7.69 | Role of bacteria in the pathogenesis of short bowel syndrome-associated D-lactic acidemia. ( Bakkeren, JA; Bongaerts, GP; Naber, AH; Severijnen, RS; Sperl, WJ; Tolboom, JJ; Willems, JL, 1997) |
| " We hypothesized that the lactic acidosis which identifies those at the greatest risk of death often represents an oxygen debt incurred as a result of inadequate tissue perfusion." | 7.69 | Lactic acidosis and oxygen debt in African children with severe anaemia. ( English, M; Marsh, K; Mithwani, S; Muambi, B, 1997) |
| "During an incremental exercise test, three consequences of the onset of anaerobic metabolism can be observed: rise in blood lactate (lactate threshold, LT); fall in standard bicarbonate (lactic acidosis threshold, LAT); nonlinear increase in CO2 output (V-slope gas exchange threshold, GET)." | 7.68 | Comparison of gas exchange, lactate, and lactic acidosis thresholds in patients with chronic obstructive pulmonary disease. ( Appendini, L; Carone, M; Casaburi, R; Donner, CF; Patessio, A; Wasserman, K, 1993) |
| "Congenital lactic acidosis form a large group of disorders that are commonly associated with profound neurological dysfunction." | 7.68 | Proton magnetic resonance spectroscopy studies in lactic acidosis and mitochondrial disorders. ( Connelly, A; Cross, JH; Gadian, DG; Leonard, JV, 1993) |
| "Plasma ionized calcium [Ca++] concentrations are decreased in patients having lactic acidosis." | 7.68 | Plasma ionized calcium and blood lactate concentrations are inversely associated in human lactic acidosis. ( Cooper, DJ; Dodek, PM; Rosenberg, F; Russell, JA; Walley, KR, 1992) |
| " Chronic lactic acidosis (lactate, 10 +/- 1 mmol/L) persisted for more than 5 wk." | 7.68 | Chronic lactic acidosis in a patient with acquired immunodeficiency syndrome and mitochondrial myopathy: biochemical studies. ( Cheema-Dhadli, S; Gopinath, R; Halperin, M; Hutcheon, M, 1992) |
| " Thus we investigated the effect of lactic acidosis and two proposed treatments on myocardial energetics and intracellular pH in anesthetized living rats." | 7.68 | Lactic acidosis: effect of treatment on intracellular pH and energetics in living rat heart. ( Barrett, E; Gore, JC; Greene, R; Majumdar, S; Zahler, R, 1992) |
| " We propose low molar ratios of ketone bodies in plasma of neonates with congenital lactic acidosis as an indication of dysfunction of the tricarboxylic acid cycle." | 7.68 | Alpha-ketoglutarate dehydrogenase deficiency presenting as congenital lactic acidosis. ( Aupetit, J; Bonnefont, JP; Charpentier, C; Chretien, D; Munnich, A; Rabier, D; Robinson, B; Rustin, P; Saudubray, JM; Vassault, A, 1992) |
| "Two patients aged 37 and 44 years developed life-threatening lactic acidosis following abdominal surgery and a period of about 3 weeks of total parenteral nutrition." | 7.68 | [Thiamine deficiency as a cause of life threatening lactic acidosis in total parenteral nutrition]. ( Asskali, F; Behne, M; Kessler, P; Klein, G; Lorenz, M; Probst, S; Steuer, A, 1991) |
| "Phenformin-induced lactic acidosis has been thought to be rare in India due to a high carbohydrate intake, use of suboptimal doses of phenformin and a lesser prevalence of alcoholism, as compared to Western countries." | 7.68 | Biguanide-induced lactic acidosis. ( Chandalia, HB; Rangnath, M, 1990) |
| "Manipulation of carbohydrate intake was used to treat severe, recurrent D-lactic acidosis in a patient with short bowel syndrome." | 7.68 | Dietary management of D-lactic acidosis in short bowel syndrome. ( Booth, IW; George, RH; Handy, DJ; Mayne, AJ; Preece, MA, 1990) |
| "Two patients, both with short bowel syndrome, presented with severe D-lactic acidosis associated with subacute small bowel obstruction and bizarre neurological signs." | 7.68 | D-lactic acidosis in short bowel syndrome--an examination of possible mechanisms. ( Hudson, M; Mowat, NA; Pocknee, R, 1990) |
| " In the investigation it was found: lactic acidosis; stroke like episodes and calcification in the basal ganglia on computerized axial tomography; ragged red fibers on muscle biopsy and decreased of cytochrome C oxidase in the muscle tissue." | 7.67 | [MELAS (mitochondrial encephalopathy, lactic acidosis and stroke-like episodes): report of a case]. ( Abdalla, H; Lohr, A; Werneck, LC, 1987) |
| "Lactic acidosis is seen frequently after severe anoxia and circulatory failure." | 7.67 | Effect of dichloroacetate in the treatment of anoxic lactic acidosis in dogs. ( Caputo, G; Delgado Paredes, C; Egler, J; Fleisher, G; Schaible, D; Sheikh, A; Swedlow, D, 1986) |
| "A mitochondrial defect was investigated in an infant with fatal congenital lactic acidosis (3-14 mM), high lactate-to-pyruvate ratio, hypotonia, and cardiomyopathy." | 7.67 | Deficiency of the reduced nicotinamide adenine dinucleotide dehydrogenase component of complex I of mitochondrial electron transport. Fatal infantile lactic acidosis and hypermetabolism with skeletal-cardiac myopathy and encephalopathy. ( Dahms, B; Hoppel, CL; Kerr, DS; Roessmann, U, 1987) |
| "The role of lactic acidosis of progressive brain hypoxia (PBH) as both a central chemoreceptor stimulant and a general respiratory depressant was assessed by preventing lactate formation both locally and globally with dichloroacetate (DCA)." | 7.67 | Role of brain lactic acidosis in hypoxic depression of respiration. ( Edelman, NH; Neubauer, JA; Simone, A, 1988) |
| " The responsiveness of these receptors to acetic, propionic, butyric and DL-lactic acids were assessed as well as their ability to be activated by rumen fluids obtained from sheep with induced ruminal lactic acidosis." | 7.67 | Ruminal lactic acidosis: forestomach epithelial receptor activation by undissociated volatile fatty acids and rumen fluids collected during loss of reticuloruminal motility. ( Crichlow, EC, 1988) |
| " strain LB17, was used to study the effects of the ionophores monensin and tetronasin on the changes in ruminal microbial ecology that occur during the onset of lactic acidosis." | 7.67 | Effects of the ionophores monensin and tetronasin on simulated development of ruminal lactic acidosis in vitro. ( Newbold, CJ; Wallace, RJ, 1988) |
| "The rat hippocampal slice preparation was used to study the combined effects of hypoxia and lactic acidosis on neuronal function." | 7.67 | Lactic acidosis and recovery of neuronal function following cerebral hypoxia in vitro. ( Dong, WQ; Reid, KH; Rigor, BM; Schurr, A; West, CA, 1988) |
| ") in rats produced tremors and convulsions with lactic acidosis which was accompanied by depletion of glycogen and activation of glycogen phosphorylase activity in triceps and diaphragm muscles, 2 h after its administration." | 7.67 | Convulsions as the etiology of lactic acidosis in acute diazinon toxicity in rats. ( Husain, K; Matin, MA; Mirza, MA, 1987) |
| "During prolonged anoxia at low temperature, freshwater turtles develop high plasma concentrations of both lactate and calcium." | 6.42 | Surviving extreme lactic acidosis: the role of calcium lactate formation in the anoxic turtle. ( Jackson, DC, 2004) |
| " Because there is little in the published scientific medical literature regarding the effects of long-term administration of probiotics to infants, potential problems must be considered; one such issue is that of administration of D(-)-lactate-producing probiotics." | 6.42 | D(-)-lactic acid-producing probiotics, D(-)-lactic acidosis and infants. ( Mack, DR, 2004) |
| " Metformin toxicity is a spectrum of conditions that may be differentiated into three subgroups: metformin-associated lactic acidosis (MALA), metformin-induced lactic acidosis (MILA), and metformin-unrelated lactic acidosis (MULA)." | 5.41 | High risk and low prevalence diseases: Metformin toxicities. ( Cao, JD; Koyfman, A; Long, B; Onisko, N; Rivera, D, 2023) |
| "Striatal lactic acidosis was performed by direct addition of lactic acid in the incubation medium to obtain a pH as close as possible to that observed in ischemia." | 5.32 | Lactic acidosis progressively impairs dopamine uptake in rat striatal synaptosomes by a mechanism partially independent of the Na+/K+-ATPase dysfunction. ( Barc-Pain, S; Barrier, L; Bestel, E; Fauconneau, B; Page, G; Stadelmann-Ingrand, S, 2004) |
| "During CO2 acidosis, anoxia had no effect on apparent nonbicarbonate buffer value (d[HCO3-]/dpHi = 71 and 89 mM/pH in normoxia and anoxia, respectively) or on pHi regulation (dpHi/dpHe = 0." | 5.28 | 31P-NMR study of normoxic and anoxic perfused turtle heart during graded CO2 and lactic acidosis. ( Arendt, EA; Inman, KC; Jackson, DC; Lawler, RG; Panol, G; Wasser, JS, 1991) |
| "Lactic acid has been shown to affect numerous biologic processes." | 5.28 | Lactic acidosis increases tumor necrosis factor secretion and transcription in vitro. ( Buresh, C; Jensen, JC; Norton, JA, 1990) |
| " Moreover, MET-associated lactic acidosis (MALA) needs to be considered and the incidence of MALA in patients with type 2 DM-TB coinfection remains unknown." | 5.27 | A case risk study of lactic acidosis risk by metformin use in type 2 diabetes mellitus tuberculosis coinfection patients. ( Mertaniasih, NM; Novita, BD; Pranoto, A; Soediono, EI, 2018) |
| " However, if used in excessive doses for patients with kidney disease, it will be contraindicated with side effects such as lactic acidosis." | 5.22 | Lactic Acidosis Associated with Metformin in Patients with Diabetic Kidney Disease. ( Rahman, F; Tuba, S, 2022) |
| " However, no study has yet discovered which factor is most important for mortality in severe sepsis patients with lactic acidosis." | 5.20 | Lactate Clearance and Vasopressor Seem to Be Predictors for Mortality in Severe Sepsis Patients with Lactic Acidosis Supplementing Sodium Bicarbonate: A Retrospective Analysis. ( An, WS; Jeong, HJ; Kim, EB; Kim, SE; Lee, SM; Son, YK, 2015) |
| "To observe the therapeutic effect of early continuous blood purification (CBP) on lactic acidosis patients." | 5.17 | [Treatment of lactic acidosis with early continuous blood purification]. ( Cai, ZX; Chen, JP; Chen, WH; Fang, XB; Li, ZY; Wu, SW; Zhang, QC, 2013) |
| " Up to 40% of children with severe malarial anaemia have associated lactic acidosis." | 5.17 | The effect of blood storage age on treatment of lactic acidosis by transfusion in children with severe malarial anaemia: a pilot, randomized, controlled trial. ( Cserti-Gazdewich, CM; Dhabangi, A; Dzik, WH; Lubega, IR; Maganda, A; Mworozi, E, 2013) |
| " However, their ability to inhibit polymerase-γ has been associated with several mitochondrial toxicities, including potentially life-threatening lactic acidosis." | 5.16 | Risk factors for symptomatic hyperlactatemia and lactic acidosis among combination antiretroviral therapy-treated adults in Botswana: results from a clinical trial. ( Bussmann, H; D'Aquila, RT; DeGruttola, V; Eden, SK; Essex, M; Hendrickson, SL; Marlink, RG; Novitsky, V; O'Brien, SJ; Samuels, DC; Shepherd, BE; Wester, CW; Winkler, CA, 2012) |
| "The purpose of this research was to report results on long-term administration of dichloroacetate in 36 children with congenital lactic acidosis who participated previously in a controlled trial of this drug." | 5.13 | Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate. ( Carney, PR; Gilbert, LR; Neiberger, RE; Shuster, JJ; Stacpoole, PW; Theriaque, DW; Valenstein, E, 2008) |
| "Increasing evidence from pathological and biochemical investigations suggests that mitochondrial metabolic impairment and oxidative stress play a crucial role in the pathogenesis of mitochondrial diseases, such as mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome, and various neurodegenerative disorders." | 5.12 | Molecular imaging for mitochondrial metabolism and oxidative stress in mitochondrial diseases and neurodegenerative disorders. ( Ikawa, M; Okazawa, H; Yoneda, M, 2021) |
| "To evaluate the role of chronic cerebral lactic acidosis in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)." | 5.11 | Cerebral lactic acidosis correlates with neurological impairment in MELAS. ( De Vivo, DC; DiMauro, S; Engelstad, K; Hirano, M; Jhung, S; Kaufmann, P; Mao, X; Mitsis, E; Sano, MC; Shanske, S; Shungu, DC, 2004) |
| "Our first objective was to determine a blood lactate threshold predictive of survival in human immunodeficiency virus patients experiencing lactic acidosis related to nucleoside analogs, and second, to test l-carnitine for the treatment of patients exceeding that threshold." | 5.10 | Detecting life-threatening lactic acidosis related to nucleoside-analog treatment of human immunodeficiency virus-infected patients, and treatment with L-carnitine. ( Azoulay, E; Branche, F; Cariou, A; Claessens, YE; Dhainaut, JF; Goldgran-Toledano, D; Monchi, M; Rouges, P; Soufir, L, 2003) |
| "To determine the influence of lactic acidosis, the Bohr effect, and exercise induced hyperkalaemia on the occurrence of the heart rate deflection point (HRDP) in elite (professional) cyclists." | 5.10 | Lactic acidosis, potassium, and the heart rate deflection point in professional road cyclists. ( Carvajal, A; Chicharro, JL; Hoyos, J; Lucía, A; Pérez, M; Santalla, A, 2002) |
| "Children with severe malaria often present with lactic acidosis and hypoglycemia." | 5.09 | Glucose and lactate kinetics in children with severe malaria. ( Agbenyega, T; Angus, BJ; Baffoe-Bonnie, B; Bedu-Addo, G; Guyton, T; Krishna, S; Stacpoole, PW, 2000) |
| " It is concluded that the greater EIH with treadmill running is a consequence of the combined effect of a reduced lactic acidosis-induced hyperventilation and greater ventilation-perfusion inequality with this exercise mode." | 5.09 | Arterial hypoxaemia in endurance athletes is greater during running than cycling. ( Chapman, MJ; Gore, CJ; Greville, HW; McNaughton, NS; Rice, AJ; Rogers, KJ; Scicchitano, R; Scroop, GC; Thornton, AT, 2000) |
| "Fatal lactic acidosis is a serious complication of therapy with nucleoside analogues." | 5.09 | Symptomatic hyperlactataemia: an emerging complication of antiretroviral therapy. ( Amiel, C; De La Tribonnière, X; Dhennain, C; Gérard, Y; Maulin, L; Maurage, CA; Mouton, Y; Robin, S; Sablonnière, B; Yazdanpanah, Y, 2000) |
| "The aim of this study was to determine the relationship between blood lactate and glucose during an incremental test after exercise induced lactic acidosis, under normal and acute beta-adrenergic blockade." | 5.09 | Effect of an acute beta-adrenergic blockade on the blood glucose response during lactate minimum test. ( Denadai, BS; Júnior, PB; Neiva, CM, 2001) |
| "Lactic acidosis frequently complicates severe malaria in African children, and is a strong independent predictor of mortality." | 5.08 | Pharmacokinetics and pharmacodynamics of dichloroacetate in children with lactic acidosis due to severe malaria. ( Agbenyega, T; Angus, BJ; Bedu-Addo, G; Henderson, G; Krishna, S; O'Brien, R; Ofori-Amanfo, G; Stacpoole, PW; Szwandt, IS, 1995) |
| " Lactic acidosis and hepatic dysfunction improved." | 5.08 | Intravenous almitrine bismesylate reversibly induces lactic acidosis and hepatic dysfunction in patients with acute lung injury. ( B'chir, A; Losser, MR; Mebazaa, A; Payen, D; Romieu, M, 1998) |
| "Marked lactic acidosis occurs during orthotopic liver transplantation (OLT), especially during the anhepatic phase." | 5.07 | Amelioration of lactic acidosis with dichloroacetate during liver transplantation in humans. ( Gallaher, EJ; Hromco, J; Robinson, ST; Shangraw, RE; Winter, R, 1994) |
| "To determine the pathogenesis and clinical course of lactic acidosis in adults receiving standard medical care." | 5.07 | Natural history and course of acquired lactic acidosis in adults. DCA-Lactic Acidosis Study Group. ( Baumgartner, TG; Bersin, RM; Buchalter, S; Curry, SH; Duncan, C; Harman, EM; Henderson, GN; Jenkinson, S; Stacpoole, PW; Wright, EC, 1994) |
| " Further, we sought to determine whether exercise training at a work rate associated with lactic acidosis is more effective in inducing a training effect in patients with COPD than a work rate not associated with lactic acidosis." | 5.07 | Ventilatory and metabolic changes as a result of exercise training in COPD patients. ( Carone, M; Donner, CF; Ioli, F; Patessio, A, 1992) |
| " We suggest that these results reflect a model of grand mal seizure-induced lactic acidosis." | 5.06 | Effect of consecutive exercise bouts on plasma potassium concentration during exercise and recovery. ( Busse, MW; Maassen, N, 1989) |
| "The reduced maximal exercise capacity of patients with heart failure has been attributed to skeletal muscle underperfusion with resultant intramuscular lactic acidosis and muscular fatigue." | 5.06 | Effect of dichloroacetate on the exercise performance of patients with heart failure. ( Egler, J; Ferraro, N; Mancini, DM; Wilson, JR, 1988) |
| "L-lactic acidosis (L-LA) is the most common cause of metabolic acidosis in the critical care setting, which has been associated with a large increase in mortality." | 5.05 | L-lactic acidosis: pathophysiology, classification, and causes; emphasis on biochemical and metabolic basis. ( Halperin, ML; Kamel, KS; Oh, MS, 2020) |
| "Metformin-associated lactic acidosis (MALA) may occur after acute metformin overdose, or from therapeutic use in patients with renal compromise." | 5.05 | Do Patients Die with or from Metformin-Associated Lactic Acidosis (MALA)? Systematic Review and Meta-analysis of pH and Lactate as Predictors of Mortality in MALA. ( Benabbas, R; Blumenberg, A; Jeng, A; Sinert, R; Wiener, SW, 2020) |
| "Metformin-associated lactic acidosis (MALA) is a rare adverse effect that has significant morbidity and mortality." | 5.05 | Osmolar-gap in the setting of metformin-associated lactic acidosis: Case report and a literature review highlighting an apparently unusual association. ( Alamin, M; Elshafei, MN; Mohamed, MFH, 2020) |
| "D-lactic acidosis is an uncommon and challenging form of metabolic acidosis that may develop in short bowel syndrome." | 4.98 | D-lactic acidosis in humans: systematic literature review. ( Agostoni, C; Amelio, GS; Bianchetti, DGAM; Bianchetti, MG; Fossali, EF; Lava, SAG; Milani, GP; Simonetti, GD, 2018) |
| "Our main finding was that probiotics and fermented formulas did not cause d-lactic acidosis in healthy children." | 4.98 | Rapid review shows that probiotics and fermented infant formulas do not cause d-lactic acidosis in healthy children. ( Salminen, S; Szajewska, H; Łukasik, J, 2018) |
| " With serum lactate values > 10 mmol/l 80 % of the patients die in intensive care, and if the severe lactic acidosis persists for 48 hours, all patients die." | 4.98 | [Lactic acidosis - update 2018]. ( de Heer, G; Fuhrmann, V; Jarczak, D; Kluge, S; Nierhaus, A, 2018) |
| "The current practice concerning timing, mode, and dose of renal replacement therapy (RRT) in patients with metformin-associated lactic acidosis (MALA) with renal failure remains unknown." | 4.95 | Serum lactate level and mortality in metformin-associated lactic acidosis requiring renal replacement therapy: a systematic review of case reports and case series. ( Kuo, CC; Ting, IW; Tsai, CW; Wu, JY; Yeh, HC, 2017) |
| "Metformin has been associated with lactic acidosis." | 4.95 | Lactate Levels with Chronic Metformin Use: A Narrative Review. ( Castelino, RL; Huang, W; Peterson, GM, 2017) |
| "Metformin-associated lactic acidosis (MALA) is a rare but potentially fatal condition that can easily be avoided." | 4.95 | [Metformin-associated lactic acidosis: an insufficiently recognised problem]. ( Bosch, FH; Kramers, C; Manders, M; van Luin, M, 2017) |
| "A review of the literature was performed, focusing on glucose and lactate in relation to cerebral energy metabolism, in the context of four typical clinical situations, namely (transient states of) low glucose availability for the brain due to hypoglycemia, combined with high blood lactate concentrations; permanent neuroglycopenia; lactic acidosis in mitochondrial disorders; and ischemic as well as traumatic brain injury." | 4.93 | Lactate and its many faces. ( Leen, WG; Taher, M; Wevers, RA; Willemsen, MA, 2016) |
| " Increased l-lactate, the isoform produced by most mammals, reflects increased anaerobic metabolism secondary to tissue hypoperfusion or tissue hypoxia in most clinical situations, and is called type A lactic acidosis." | 4.93 | Point of Care Measurement of Lactate. ( Di Mauro, FM; Schoeffler, GL, 2016) |
| "Type B lactic acidosis represents a rare and often lethal complication of haematological malignancy." | 4.91 | A case of type B lactic acidosis as a complication of chronic myelomonocytic leukaemia: a case report and review of the literature. ( Gardner, AJ; Griffiths, J, 2015) |
| "Metformin poisoning with lactic acidosis appears to be amenable to extracorporeal treatments." | 4.91 | Extracorporeal Treatment for Metformin Poisoning: Systematic Review and Recommendations From the Extracorporeal Treatments in Poisoning Workgroup. ( Calello, DP; Ghannoum, M; Gosselin, S; Hoffman, RS; Lavergne, V; Liu, KD; Nolin, TD; Roberts, DM; Wiegand, TJ, 2015) |
| " In each case, severe metabolic lactic acidosis was identified through routine laboratory diagnostics." | 4.91 | [Lactic acidosis in the postictal state]. ( Admiraal-van de Pas, Y; van Rooij, FJ, 2015) |
| "The aim was to justify less restrictive use of metformin in stable chronic renal failure, because a literature review reveals metformin is associated with a significantly lower incidence of cardiovascular events and mortality compared with other hypoglycaemic agents, and metformin-associated lactic acidosis is rare and causation uncertain." | 4.90 | A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure. ( Adam, WR; O'Brien, RC, 2014) |
| " This review discusses 3 issues that concern homeostasis in the acute care of trauma patients directly related to the stress response: hyperglycemia, lactic acidosis, and hypothermia." | 4.89 | Trauma and aggressive homeostasis management. ( Baranov, D; Neligan, PJ, 2013) |
| "Hyperlactataemia and lactic acidosis are commonly encountered during and after cardiac surgery." | 4.88 | The interpretation of perioperative lactate abnormalities in patients undergoing cardiac surgery. ( Fraser, JF; O'Connor, E, 2012) |
| " Metformin, however, is thought to increase the risk of lactic acidosis, and has been considered to be contraindicated in many chronic hypoxemic conditions that may be associated with lactic acidosis, such as cardiovascular, renal, hepatic and pulmonary disease, and advancing age." | 4.86 | Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. ( Greyber, E; Pasternak, GA; Salpeter Posthumous, EE; Salpeter, SR, 2010) |
| "Lactic acidosis is a common condition encountered by critical care providers." | 4.86 | Lactic acidosis: recognition, kinetics, and associated prognosis. ( Letourneau, JL; Vernon, C, 2010) |
| " Metformin, however, is thought to increase the risk of lactic acidosis, and has been considered to be contraindicated in many chronic hypoxemic conditions that may be associated with lactic acidosis, such as cardiovascular, renal, hepatic and pulmonary disease, and advancing age." | 4.86 | Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. ( Greyber, E; Pasternak, GA; Salpeter, EE; Salpeter, SR, 2010) |
| " During the past decade, however, evidence has accumulated that d-lactic acidosis is a more common occurrence in calves with neonatal diarrhoea." | 4.85 | D-Lactic acidosis in calves. ( Lorenz, I, 2009) |
| "Severe hyperlactataemia and lactic acidosis are rare serious complications of antiretroviral therapy (ART)." | 4.84 | Risk factors for lactic acidosis and severe hyperlactataemia in HIV-1-infected adults exposed to antiretroviral therapy. ( , 2007) |
| " Suspected antiretroviral toxicities meeting these criteria include: HIV-associated lipodystrophy which can include peripheral lipoatrophy, lipohypertrophy and metabolic abnormalities; hyperlactatemia and lactic acidosis; and metabolic bone abnormalities such as decreased bone mineral density, osteoporosis and osteonecrosis." | 4.82 | Emerging drug toxicities of highly active antiretroviral therapy for human immunodeficiency virus (HIV) infection. ( Bondy, G; Heath, KV; Hogg, RS; Montaner, JS; O'Shaughnessy, MV; Singer, J, 2003) |
| " NRTIs can induce mitochondrial impairment that leads to a number of adverse events, including symptomatic lactic acidosis." | 4.82 | Bench-to-bedside review: severe lactic acidosis in HIV patients treated with nucleoside analogue reverse transcriptase inhibitors. ( Cariou, A; Chiche, JD; Claessens, YE; Mira, JP, 2003) |
| " Lactic acidosis is being re-evaluated as a factor in muscle fatigue." | 4.82 | Lactate metabolism: a new paradigm for the third millennium. ( Gladden, LB, 2004) |
| "The development of acidosis during intense exercise has traditionally been explained by the increased production of lactic acid, causing the release of a proton and the formation of the acid salt sodium lactate." | 4.82 | Biochemistry of exercise-induced metabolic acidosis. ( Ghiasvand, F; Parker, D; Robergs, RA, 2004) |
| "Nucleoside reverse-transcriptase inhibitors (NRTIs) have been associated with functional and structural mitochondrial abnormalities, leading to several adverse events, such as increased serum lactic acid levels and lactic acidosis." | 4.82 | Hyperlactataemia and lactic acidosis in HIV-infected patients receiving antiretroviral therapy. ( Calza, L; Chiodo, F; Manfredi, R, 2005) |
| "This report describes a case of d-lactic acidosis observed by the authors and then reviews all case reports of d-lactic acidosis in the literature in order to define its clinical and biochemical features and pathogenetic mechanisms." | 4.80 | D-lactic acidosis. A review of clinical presentation, biochemical features, and pathophysiologic mechanisms. ( Carroll, HJ; Oh, MS; Uribarri, J, 1998) |
| " D-Lactic acidosis was diagnosed on the basis of a D-lactate level of 8." | 4.80 | D-lactic acidosis: pathologic consequence of saprophytism. ( Farrugia, G; Vella, A, 1998) |
| " Sustained lactic acidosis, or changes in lactate in response to inotropic support, are useful predictors of mortality in severe sepsis and trauma, and superior to hemodynamic markers such as DO2 and VO2." | 4.80 | Lactate in sepsis and trauma--hindrance or help? ( Sladen, RN, 1999) |
| "Bovine lactic acidosis syndrome is associated with large increases of lactic acid in the rumen, which result from diets that are high in ruminally available carbohydrates, or forage that is low in effective fiber, or both." | 4.79 | Bovine acidosis: implications on laminitis. ( Nocek, JE, 1997) |
| "This article reviews the current body of knowledge regarding lactic acidosis in critically ill patients." | 4.78 | Lactic acidosis in critical illness. ( Falk, JL; Mizock, BA, 1992) |
| "A new patient with neonatal lactic acidosis due to pyruvate carboxylase deficiency is described." | 4.77 | [Neonatal lactic acidosis caused by severe pyruvate carboxylase deficiency]. ( Cortés Coto, MT; del Valle Martínez, J; García Aparicio, J; García Muñoz, MJ; Merinero Cortés, B; Pérez-Cerdá Silvestre, C; Sáez Pérez, E; Ugarte Pérez, M, 1988) |
| "Lactic acidosis is a clinical status related to clinical worsening." | 4.31 | Development of a prehospital lactic acidosis score for early-mortality. A prospective, multicenter, ambulance-based, cohort study. ( Castro Villamor, MA; Del Pozo Vegas, C; Delgado Benito, JF; López-Izquierdo, R; Martín-Conty, JL; Martín-Rodríguez, F; Ortega, GJ; Sanz-García, A, 2023) |
| "Lactic acidosis is a disease in which lactic acid accumulates in the blood and causes acidosis in the patient." | 4.31 | Metformin-associated severe lactic acidosis combined with multi-organ insufficiency induced by infection with Aeromonas veronii: A case report. ( Wu, C; Xia, Y; Zhu, X, 2023) |
| "Linezolid-induced lactic acidosis is a rare, but life-threatening complication of a commonly used drug." | 4.31 | Mitochondrial toxicity induced by linezolid causing lactic acidosis. ( Dass, J; Keri, VC; Kumar, TP; Mishra, RK; Sethi, P; Sharma, K, 2023) |
| "Lactic acidosis characterizes the tumor microenvironment (TME) and is involved in the mechanisms leading to cancer progression and dissemination through the reprogramming of tumor and local host cells (e." | 4.31 | Extracellular Lactic Acidosis of the Tumor Microenvironment Drives Adipocyte-to-Myofibroblast Transition Fueling the Generation of Cancer-Associated Fibroblasts. ( Andreucci, E; Biagioni, A; Calorini, L; Fioretto, BS; Manetti, M; Matucci-Cerinic, M; Romano, E; Rosa, I, 2023) |
| "We report a 76-year-old Caucasian woman with double-expressor diffuse large B cell lymphoma who presented with severe lactic acidosis and extreme hypoglycemia with normal mentation." | 4.31 | Clinical presentation of Warburg effect in aggressive lymphoma: a case report. ( Afzal, MZ; Cao, Y; Chen, Y; Hanlon, EL; Hayes, CA; Hill, JM; Liu, MC, 2023) |
| " Lactic acidosis correlates with cancer malignancy, and the benefit it offers to tumours has been the subject of numerous hypotheses." | 4.31 | Warburg-associated acidification represses lactic fermentation independently of lactate, contribution from real-time NMR on cell-free systems. ( Bendridi, N; Berger, MA; Brunet, L; Daverio, Z; Kolkman, M; Panthu, B; Perrier, J; Rautureau, GJP; Sanglar, C, 2023) |
| "Type B lactic acidosis is a rare but serious side effect of metformin use." | 4.31 | Treatment of severe metformin-associated lactic acidosis with renal replacement therapy and tris-hydroxymethyl aminomethane: a case report. ( Abdullin, M; Braden, GL; Hodgins, S; Landry, DL; Tiru, B; Yusim, D, 2023) |
| " LDHD mutations identified in patients with D-lactic acidosis lead to deficient LDHD activity." | 4.31 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. ( Chen, X; Ding, J; Jin, S; Yang, J, 2023) |
| "Splenic rupture followed by lactic acidosis and hypoglycaemia should lead to suspicion of a cancer-mediated Warburg effect, and prompt urgent chemotherapy." | 4.31 | B-cell hepatosplenic lymphoma presenting in adult patient after spontaneous splenic rupture followed by severe persistent hypoglycaemia: type B lactic acidosis and acute liver failure. ( Gude, MF; Hamilton-Dutoit, S; Moen, M; Steiniche, T, 2023) |
| " l-lactic acidosis, a common condition comprising high l-lactate concentration and acidic pH in the tumor microenvironment, has been known to induce tumor metastasis and drug resistance." | 4.12 | l-lactic acidosis confers insensitivity to PKC inhibitors by competing for uptake via monocarboxylate transporters. ( Chen, CH; Chen, CJ; Cheng, FJ; Chiou, JY; Huang, WC; Liu, YC; Nguyen, KTL; Shen, YC; Tang, CH; Tu, CY, 2022) |
| " The present study aims to evaluate the factors that may contribute to the decision whether to start RRT or not and the potential impact of the start of RRT on the outcome in patients with severe lactic acidosis (SLA) (lactate ≥5 mmol/L)." | 4.12 | Patients with Severe Lactic Acidosis in the Intensive Care Unit: A Retrospective Study of Contributing Factors and Impact of Renal Replacement Therapy. ( Hoste, EAJ; Kruse, JM; Van Biesen, W; Van De Ginste, L; Vanommeslaeghe, F; Verbeke, F, 2022) |
| "Type B lactic acidosis is a rare complication of non-tissue perfusion abnormalities caused by solid tumors or hematologic malignancies." | 4.12 | Type B lactic acidosis associated with diffuse large B-cell lymphoma and the Warburg effect. ( Lv, Z; Wang, C; Zhang, Y, 2022) |
| "The combination of propylene glycol ingestion and alcoholic ketoacidosis may have contributed to the severity of lactic acidosis." | 4.12 | Unexplained Metabolic Acidosis: Alcoholic Ketoacidosis or Propylene Glycol Toxicity. ( Boland, L; de Landsheere, F; Dewulf, JP; Dulaurent, S; Hantson, P; Haufroid, V; Laterre, PF; Saint-Marcoux, F, 2022) |
| " However, the mutual dependence between lactate dehydrogenase (LDH) catalytic action and lactic acidosis is far from being fully understood." | 4.12 | Allosteric transitions of rabbit skeletal muscle lactate dehydrogenase induced by pH-dependent dissociation of the tetrameric enzyme. ( Binda, C; Brigotti, M; Cerini, S; Dal Piaz, F; Di Stefano, G; Hochkoeppler, A; Iacovino, LG; Pasti, AP; Rossi, M; Rossi, V; Tomaselli, F, 2022) |
| "Background Lactic acidosis is associated with mortality in patients with cardiogenic shock (CS)." | 4.12 | Association Between the Acidemia, Lactic Acidosis, and Shock Severity With Outcomes in Patients With Cardiogenic Shock. ( Barsness, GW; Blankenberg, S; Holmes, DR; Jentzer, JC; Kashani, KB; Kirchhof, P; Patel, PC; Schrage, B; Westermann, D, 2022) |
| "Lactic acidosis is a rare but life-threatening complication associated with prolonged linezolid therapy." | 4.12 | Linezolid Intoxication with Extreme Lactate Blood Levels Successfully Treated with Dialytic Treatment in ICU: A Case Report. ( Agrò, FE; Chello, M; Mattei, A; Nenna, A; Pascarella, G; Schiavoni, L; Strumia, A, 2022) |
| " The authors sought to provide evidence through a retrospective data analysis that helps investigate the relationship between intraoperative opioid dosage and postoperative lactic acidosis after cardiac surgery." | 4.12 | Sufentanil: a risk factor for lactic acidosis in patients after heart valve surgery. ( Ge, YP; Jiang, W; Luo, TG; Pan, YC; Shi, Q; Xiao, ZH; Zhan, YF; Zheng, BS, 2022) |
| " The case of an extremely premature infant with hyperglycemia and lactic acidosis associated with linezolid is reported." | 4.12 | Hyperglycemia and Lactic Acidosis Associated with Linezolid Therapy in an Extremely Premature Infant. ( Aoyama, M; Asai, S; Asai, T; Kakita, H; Mizuno, Y; Mori, M; Nakamura, N; Takeshita, S; Tomita, A; Ueda, H; Yamada, Y, 2022) |
| "Lactic acidosis, the extracellular accumulation of lactate and protons, is a consequence of increased glycolysis triggered by insufficient oxygen supply to tissues." | 4.02 | Acetoacetate protects macrophages from lactic acidosis-induced mitochondrial dysfunction by metabolic reprograming. ( Adam, C; Beauvillain, C; Blanchard, S; Delneste, Y; Gueguen, N; Jeannin, P; Le Mao, M; Mabilleau, G; Manero, F; Morel, A; Paolini, L; Pignon, P; Preisser, L; Procaccio, V; Reynier, P, 2021) |
| "D-lactic acidosis represents a rare form of metabolic acidosis that occurs most commonly in patients with short bowel syndrome." | 4.02 | D-lactic acidosis - a rare complication of short bowel syndrome. ( Majdák, P; Morgošová, S; Podušel, V; Sadloňová, J, 2021) |
| " Initial severe acidosis consisted of acute respiratory acidosis from ventilation-perfusion mismatch and acute metabolic acidosis resulting from bronchospasm and hypoxia-related lactic acidosis, respectively." | 4.02 | Salbutamol-induced lactic acidosis in status asthmaticus survivor. ( Boonkaya, S; Phoophiboon, V; Singhagowinta, P; Sriprasart, T, 2021) |
| "Metformin-associated lactic acidosis (MALA) is a widely documented adverse event of metformin." | 4.02 | The usefulness of measuring the anion gap in diagnosing metformin-associated lactic acidosis: a case series. ( Agra-Montava, I; Juanes-Borrego, A; Lozano-Polo, L; Mangues-Bafalluy, MA; Puig-Campmany, M; Ruiz-Ramos, J, 2021) |
| " Initial workup showed profound lactic acidosis on a point-of-care arterial blood gas, without clinical signs of hypoperfusion." | 4.02 | Spurious point-of-care lactate elevation in ethylene glycol intoxication: rediscovering a clinical pearl. ( Poirier-Blanchette, L; Schwartz, BC; Simard, C, 2021) |
| " Inhibition of mitochondrial respiration likely explains lactate formation in the brain during metformin infusion which may cause lactic acidosis during metformin intoxication." | 4.02 | Cholinergic and metabolic effects of metformin in mouse brain. ( Klein, J; Lau, H; Lehto, A; Piechotta, C; Thinnes, A; Westenberger, M; Wirth, F, 2021) |
| "D-lactic acidosis is an uncommon cause of high anion gap acidosis." | 3.96 | High anion gap metabolic acidosis caused by D-lactate: mind the time of blood collection. ( Hiele, M; Vermeersch, P; Weemaes, M, 2020) |
| "The FDA approved 'label' for metformin lists hepatic insufficiency as a risk for lactic acidosis." | 3.96 | The safety and pharmacokinetics of metformin in patients with chronic liver disease. ( Braithwaite, HE; Carland, JE; Cheng, TS; Danta, M; Day, RO; Graham, GG; Greenfield, JR; Kumar, SS; Liu, Z; Smith, FC; Stocker, SL; Williams, KM, 2020) |
| " We therefore hypothesised that lactic acidosis may confer resistance to Akt inhibition." | 3.96 | Lactic acidosis induces resistance to the pan-Akt inhibitor uprosertib in colon cancer cells. ( Aboagye, EO; Barnes, EME; Benito, A; Herendi, L; Keun, HC; Nijhuis, A; Siskos, AP; Xu, Y, 2020) |
| " Organic acids in urine analysis, in addition to the clinical context, suggested a diagnosis of D-lactic acidosis." | 3.96 | [An acidosis not so basic]. ( Benoist, JF; Ecochard-Dugelay, E; Hugot, JP; Imbard, A; Lefrère, B; Mosca, A, 2020) |
| "Metformin-associated lactic acidosis (MALA) carries a high mortality rate." | 3.96 | Metformin-associated lactic acidosis: reinforcing learning points. ( Creagh, F; Goonoo, MS; Morris, R; Raithatha, A, 2020) |
| " We report three cases of prospectively identified laboratory confirmed metformin-associated lactic acidosis admitted to our intensive care unit." | 3.91 | Laboratory-Confirmed Metformin-Associated Lactic Acidosis ( Canavan, C; Coyle, N; Nasim, S; Nestor, C, 2019) |
| "This study aims to determine whether there is a relationship between nausea level and lactic acidosis during recovery from sprinting." | 3.91 | Role of lactic acidosis as a mediator of sprint-mediated nausea. ( Chivers, PT; Cripps, AJ; Fournier, PA; Merrells, RJ, 2019) |
| " High PG levels can cause lactic acidosis." | 3.91 | Spectroscopic detection of brain propylene glycol in neonates: Effects of different pharmaceutical formulations of phenobarbital. ( Pouwels, PJW; van de Lagemaat, M; van de Pol, LA; Witjes, BCM; Zonnenberg, IA, 2019) |
| " A 48-week, prospective, single-centre, exploratory, clinical study enrolled 11 Japanese adult patients with genetically, biochemically, and clinically confirmed mitochondrial disease; they had intractable lactic acidosis and received SP (0." | 3.91 | Biomarkers and clinical rating scales for sodium pyruvate therapy in patients with mitochondrial disease. ( Inoue, E; Koga, Y; Nashiki, K; Povalko, N; Tanaka, M, 2019) |
| " This broadens the differential diagnosis of D-lactic acidosis, an increasingly recognized complication of short bowel syndrome with unpredictable onset and severity." | 3.91 | Identification of human D lactate dehydrogenase deficiency. ( Bakkers, J; Bosco, P; Calì, F; de Koning, TJ; de Sain-van der Velden, MGM; Duran, KJ; Duran, M; Fuchs, SA; Geleijns, K; Gerrits, J; Jans, JJ; Knoers, NV; Koot, BG; Lichtenbelt, KD; Monroe, GR; Oostendorp, M; Savelberg, SMC; Terhal, PA; Tessadori, F; van Aalderen, M; van Alfen, JC; van der Crabben, SN; van Eerde, AM; van Gassen, KL; van Haaften, G; van Roosmalen, MJ; Verhoeven-Duif, NM; Visser, G, 2019) |
| "To study the incidence of lactic acidosis due to metformin in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) stage 3-5." | 3.91 | Lactic acidosis due to metformin in type 2 diabetes mellitus and chronic kidney disease stage 3-5: is it significant? ( Guddattu, V; Mareddy, AS; Nagaraju, SP; Prabhu, RA; Rangaswamy, D, 2019) |
| " The primary outcomes were: (1) hyperlactatemia, defined as a lactate concentration ≥ 2 mmol/L at any point during hospital admission and, (2) metformin associated lactic acidosis (MALA), defined as a lactate concentration ≥ 5 mmol/L and pH <7." | 3.91 | Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose. ( Hoffman, RS; Manini, AF; Taub, ES, 2019) |
| "Gap acidosis except lactic acidosis developed and progressed during the CKD stage G5, while lactic acidosis developed in the CKD stages G1-4." | 3.91 | Gap acidosis except lactic acidosis develops and progresses during chronic kidney disease stage G5. ( Tanemoto, M, 2019) |
| "Metformin-associated lactic acidosis is a rare but serious complication of taking metformin." | 3.91 | Metformin-Associated Lactic Acidosis Presenting Like Acute Mesenteric Ischemia. ( Hastings, C; Johnson, K; Slaven, E; Zhang, QC, 2019) |
| " We aimed to follow the variation of some biochemical and clinical parameters in T2D patients before and after Ramadan; and to determine the incidence of fasting on hypoglycaemia and lactic acidosis associated with antidiabetic agents such as metformin." | 3.91 | Follow-up of glycemic index before and after Ramadan fasting in type 2 diabetes patients under antidiabetic medications. ( Abdessadek, M; Ajdi, F; Khabbal, Y; Magoul, R; Marmouzi, I, 2019) |
| "Pharmacokinetic data suggest that the risk of metformin-associated lactic acidosis (MALA) may be increased after Roux-en-Y gastric bypass (RYGB) surgery." | 3.88 | Risk of Metformin-Associated Lactic Acidosis (MALA) in Patients After Gastric Bypass Surgery. ( Aarts, EO; Aelfers, SCW; Berends, FJ; de Boer, H; Deden, LN; Janssen, IMC; van Borren, MMGJ, 2018) |
| "In the general population, the absolute risk of lactic acidosis in patients treated with metformin appears to be low." | 3.88 | Safety of Metformin Therapy in Patients with Type 2 Diabetes Living on an Oxygen-Deficient Plateau, Tibet, China. ( Geng, Y; Lv, X; Meng, S; Mina, A; Puchi, B; Ren, Q; Song, J; Yang, L; Yang, S; Zhou, L, 2018) |
| "Lactic acidosis is a rare complication of linezolid (LZD) therapy, and its incidence and risk factors remain unknown." | 3.88 | Comparative analysis of lactic acidosis induced by linezolid and vancomycin therapy using cohort and case-control studies of incidence and associated risk factors. ( Aoki, Y; Bito, S; Hirose, S; Kamimura, Y; Kimura, Y; Mori, N, 2018) |
| " We describe 2 children with SBS who we believe are the second and third patients documented to have experienced both D-lactic acidosis and urolithiasis." | 3.88 | Stoned-A Syndrome of D-Lactic Acidosis and Urolithiasis. ( Berman, CM; Merritt, RJ, 2018) |
| "D-lactic acidosis is an infrequent complication, mainly reported in patients with short bowel syndrome." | 3.88 | [Dietetic treatment with fructose in a 5-year-old girl with recurrent D-lactic acidosis]. ( Pedrón Giner, C; Quijada Fraile, P; Travieso Suárez, L, 2018) |
| " D-lactic acidosis (D-LA) is a metabolic disorder that may occur in individuals with short bowel syndrome when lactate-producing bacteria in the colon overproduce D-lactate." | 3.88 | Intestinal Microbial and Metabolic Alterations Following Successful Fecal Microbiota Transplant for D-Lactic Acidosis. ( Bulik-Sullivan, EC; Carroll, IM; Elliott, RJ; Gulati, AS; Kassam, Z; Lichtman, SN; Roy, S, 2018) |
| "D-lactic acidosis is characterized by brain fogginess (BF) and elevated D-lactate and occurs in short bowel syndrome." | 3.88 | Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis. ( Andino, NM; Rao, SSC; Rehman, A; Yu, S, 2018) |
| " An increase of D-lactate-producing bacteria can lead to D-lactic acidosis, also referred to as D-lactate encephalopathy, with severe neurologic impairment." | 3.88 | D-lactic Acidosis: Successful Suppression of D-lactate-Producing ( Macpherson, AJ; Schibli, S; Sokollik, C; Yilmaz, B, 2018) |
| "The application of iodinated contrast medium has become a risk factor for metformin-associated lactic acidosis (MALA), which leads to the accumulation of metformin in vivo is one of the principal reasons for MALA." | 3.88 | Involvement of organic cation transporter 2 in the metformin-associated increased lactate levels caused by contrast-induced nephropathy. ( Dai, Y; Huo, X; Liu, K; Liu, Z; Ma, X; Meng, Q; Peng, J; Sun, H; Wang, C; Yang, S, 2018) |
| "Lactic acidosis in the emergency department and other hospital settings is typically due to tissue hypoxia with sepsis being the most common cause." | 3.88 | Lactic Acidosis in a Critically Ill Patient: Not Always Sepsis. ( Leger, KJ; Schuh, AM; Summers, C; Uspal, NG, 2018) |
| " Plasmodium falciparum infection can cause severe malaria anaemia (SMA) with insufficient tissue oxygenation, lactic acidosis and death." | 3.88 | Mitochondrial gene sequence variants in children with severe malaria anaemia with or without lactic acidosis: a case control study. ( Amr, SS; Cserti-Gazdewich, C; Dhabangi, A; Dzik, W; Fowler, C; Musoke, C; Sharma, H, 2018) |
| "Metformin is renally excreted and has been associated with the development of lactic acidosis." | 3.85 | Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study. ( Connelly, PJ; Donnelly, L; Lonergan, M; Pearson, ER; Soto-Pedre, E; Zhou, K, 2017) |
| "Chronic metformin treatment mildly increases lactate level, but does not induce hyperlactatemia or lactic acidosis in acute illness on the first day of admission to an internal medicine ward." | 3.85 | Metformin Does Not Induce Hyperlactatemia in Patients Admitted to Internal Medicine Ward. ( Doenyas-Barak, K; Golik, A; Koren, R; Koren, S; Zilberman-Itskovich, S, 2017) |
| "Lactic acidosis represents the pathologic accumulation of lactate and hydrogen ions." | 3.85 | Low sensitivity of anion gap to detect clinically significant lactic acidosis in the emergency department. ( Cembrowski, GS; Fuezery, A; HowlettClyne, S; Xu, Q, 2017) |
| "None of the patients developed lactic acidosis during follow-up [median: 58 (6-155) months]." | 3.85 | Lactate serum concentrations during treatment with nucleos(t)ide analogues in hepatitis B with or without cirrhosis. ( Aggeletopoulou, I; Anastassiou, ED; Assimakopoulos, S; Gogos, C; Kalafateli, M; Labropoulou-Karatza, C; Mandellou, M; Taprantzi, D; Thomopoulos, K; Triantos, C; Tselekouni, P; Tsiaoussis, G; Vourli, G, 2017) |
| " Peripheral venoarterial extracorporeal membrane oxygenation (splanchnic ECMO) may be more effective at reducing lactic acidosis for these patients." | 3.85 | Peripheral venoarterial extracorporeal membrane oxygenation for severe hyperlactataemia after cardiac surgery: a pilot study. ( Bellomo, R; Biesenbach, P; Crisman, M; Ghanpur, R; Hilton, A; Lindstrom, S; Mårtensson, J; Matalanis, G, 2017) |
| "To investigate the effect of lactic acidosis on the survival of Lewis lung carcinoma cells under glucose-deprived conditions." | 3.85 | Impact of lactic acidosis on the survival of Lewis lung carcinoma cells. ( Kolesnik, DL; Pyaskovskaya, ON; Solyanik, GI, 2017) |
| "D-lactic acidosis can occur in patients with short bowel syndrome (SBS) when excessive malabsorbed carbohydrate (CHO) enters the colon and is metabolized by colonic bacteria to D-lactate." | 3.85 | Fecal Transplantation Successfully Treats Recurrent D-Lactic Acidosis in a Child With Short Bowel Syndrome. ( Davidovics, ZH; Etienne, N; Hyams, JS; Vance, K, 2017) |
| " There was no difference in prevalence of hyperlactatemia and lactic acidosis between the patients with and without metformin use (18." | 3.85 | Association between Metformin Use and Risk of Lactic Acidosis or Elevated Lactate Concentration in Type 2 Diabetes. ( Cha, BS; Han, E; Hwang, S; Kang, ES; Kang, HP; Lee, BW; Lee, EY; Lee, HC; Lee, SH; Lee, W; Lee, YH; Lee, YM, 2017) |
| "The role of metformin in lactic acidosis is regularly questioned." | 3.83 | Lactic acidosis: relationship between metformin levels, lactate concentration and mortality. ( Altman, JJ; Boucaud-Maitre, D; Bouhanick, B; Doucet, J; Emmerich, J; Girardin, E; Kaloustian, E; Lassmann Vague, V; Porokhov, B; Ropers, J, 2016) |
| "To evaluate the strength of association between lactic acidosis (LA) and well-recognized risk factors for LA, particularly the weight of metformin." | 3.83 | Lactic Acidosis in Diabetic Population: Is Metformin Implicated? Results of a Matched Case-Control Study Performed on the Type 2 Diabetes Population of Grenoble Hospital University. ( Chanoine, S; Giai, J; Lepelley, M; Villier, C; Yahiaoui, N, 2016) |
| " Hemodialysis appears to be a beneficial therapeutic option in cases of massive acetaminophen ingestion with coma and lactic acidosis." | 3.83 | Massive acetaminophen overdose: effect of hemodialysis on acetaminophen and acetylcysteine kinetics. ( Ghannoum, M; Gosselin, S; Grunbaum, AM; Kazim, S; Villeneuve, E, 2016) |
| "Lactic acidosis during metformin intoxication is classically mainly attributed to diminished lactate clearance through liver gluconeogenesis." | 3.83 | Skeletal muscle lactate overproduction during metformin intoxication: An animal study with reverse microdialysis. ( Bassani, G; Ferrero, S; Gattinoni, L; Guenzani, S; Langer, T; Magnoni, S; Properzi, P; Protti, A; Santini, A; Stocchetti, N, 2016) |
| "We report a case of metformin-associated lactic acidosis (MALA) in the setting of normal renal function and review the relevant medical literature." | 3.83 | Metformin-Associated Lactic Acidosis in a Patient with Normal Renal Function. ( Ellen, R; Omar, A; Sorisky, A, 2016) |
| " Our previous works suggested that cancer cells reverted to OXPHOS, when they were exposed to lactic acidosis, a common factor in tumor environment." | 3.83 | Lactic acidosis switches cancer cells from aerobic glycolysis back to dominant oxidative phosphorylation. ( Hu, X; Wu, H; Ying, M, 2016) |
| "Lactic acidosis is common in critical care; by contrast, a subtype called alcohol-associated lactic acidosis (AALA) is rarely encountered." | 3.83 | Prognosis of alcohol-associated lactic acidosis in critically ill patients: an 8-year study. ( Chan, KS; Tseng, KL; Weng, SF; Yang, CC, 2016) |
| "Lactic acidosis (LA) frequently occurs after heart transplantation (HTx)." | 3.81 | Lactic acidosis after cardiac transplantation: foe or common innocent bystander? ( Alharethi, R; Bair, T; Balling, KD; Brunisholz, K; Budge, D; Doty, J; Goddard, M; Kfoury, AG; McCubrey, R; Nixon, JL; Rasmusson, B; Reid, B; Smith, H; Thomsen, G, 2015) |
| " Here we sought to identify whether the enhanced lactic acidosis and increased expression of monocarboxylate transporters (MCTs) observed after stroke might be attenuated by single and/or combined EtOH and NBO therapies." | 3.81 | Reduced cerebral monocarboxylate transporters and lactate levels by ethanol and normobaric oxygen therapy in severe transient and permanent ischemic stroke. ( Brogan, D; Cai, L; Ding, Y; Du, H; Geng, X; Ji, X; Kwiecien, TD; Peng, C; Rafols, JA; Rastogi, R; Singh, S; Sy, CA, 2015) |
| " One in particular, D-lactic acidosis, causes a neurologic syndrome characterized by altered mental status, slurred speech, and ataxia, typically after a large carbohydrate meal." | 3.81 | A 3-year-old boy with ataxia. ( Fichadia, U; Park, B; Shah, A, 2015) |
| "The March 2012 regulatory action issued by the Japanese government signalled the rare but serious complication of lactic acidosis that can occur during metformin treatment, especially with the high dose formulation, h-metformin, and in those above 75 years old." | 3.81 | Impact of Japanese regulatory action on metformin-associated lactic acidosis in type II diabetes patients. ( Hanatani, T; Sai, K; Saito, Y; Segawa, K; Tohkin, M, 2015) |
| "Metformin-induced lactic acidosis is a rare but severe disease for the individual patients." | 3.81 | [Metformin-induced lactic acidosis : Severe symptoms with difficult diagnostics]. ( Brenner, T; Decker, SO; Hofer, S; Siegler, BH; Ulrich, A; Wortmann, M, 2015) |
| " However, due to its rare association with lactic acidosis, its safety in COPD is uncertain." | 3.81 | Safety of metformin in patients with chronic obstructive pulmonary disease and type 2 diabetes mellitus. ( Archer, JR; Baker, EH; Hitchings, AW; Srivastava, SA, 2015) |
| " These data demonstrate for the first time that energy depletion may lead to lactic acidosis in the DMRC patient by reduction of lactate uptake via AMPK in liver." | 3.81 | Mitochondrial Respiratory Defect Causes Dysfunctional Lactate Turnover via AMP-activated Protein Kinase Activation in Human-induced Pluripotent Stem Cell-derived Hepatocytes. ( Choi, JH; Han, YM; Im, I; Jang, MJ; Kim, S; Lee, SH; Park, SJ; Yoo, HW, 2015) |
| "Thiamine functions as an important cofactor in aerobic metabolism and thiamine deficiency can contribute to lactic acidosis." | 3.80 | The relationship between lactate and thiamine levels in patients with diabetic ketoacidosis. ( Berg, K; Donnino, MW; Gautam, S; Giberson, T; Graver, A; Liu, X; Moskowitz, A; Uber, A, 2014) |
| " All cases of lactic acidosis (pH, ≤ 7." | 3.80 | Metformin accumulation: lactic acidosis and high plasmatic metformin levels in a retrospective case series of 66 patients on chronic therapy. ( Giampreti, A; Locatelli, CA; Lonati, D; Manzo, L; Papa, P; Petrolini, VM; Protti, A; Rocchi, L; Rognoni, C; Rolandi, L; Valli, A; Vecchio, S, 2014) |
| "The relative desirable lactate imprecision for patients with lactic acidosis is about half that of normal individuals." | 3.80 | Tighter precision target required for lactate testing in patients with lactic acidosis. ( Cembrowski, GS; Chin, D; Holmes, D; Kunst, AN; Redel, S; Rimkus, M; Tran, D; Versluys, KA, 2014) |
| " Mutation carriers included 45 patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS); 11 participants who would develop the MELAS syndrome during follow-up (converters); and 79 participants who would not develop the MELAS syndrome during follow-up (nonconverters)." | 3.80 | Cerebral metabolic abnormalities in A3243G mitochondrial DNA mutation carriers. ( De Vivo, D; DiMauro, S; Engelstad, KM; Hinton, V; Kaufmann, P; Mao, X; Shungu, D; Weiduschat, N, 2014) |
| "In a number of patients, the antidiabetic drug metformin has been associated with lactic acidosis." | 3.80 | Metformin in peritoneal dialysis: a pilot experience. ( Abdul-Rahman, IS; Al-Hwiesh, AK; Al-Mohanna, FA; Divino-Filho, JC; El-Deen, MA; Gupta, KL; Larbi, E, 2014) |
| "Severe lactic acidosis (SLA) is frequent in intensive care unit (ICU) patients with acute kidney injury (AKI) treated with renal replacement therapy (RRT)." | 3.80 | Severe lactic acidosis in critically ill patients with acute kidney injury treated with renal replacement therapy. ( De Corte, W; De Waele, JJ; Decruyenaere, J; Dhondt, AW; Hoste, EA; Vanholder, R; Vuylsteke, S, 2014) |
| "Neuroprotective properties of the new derivative of glutamic and apovincaminic acids, ethyl -(3-alpha,16-alpha)-eburnamenin-14-carbopxylate of 2-aminopentadionic acid (LHT 1-02) were studied on a model of acute brain ischemia in cats." | 3.80 | [Effect of a new derivative of glutamic and apovincaminic acids on brain metabolism in post-ischemic period]. ( Makarova, LM; Mirzoian, RS; Pogorelyĭ, VE; Prikhod'ko, MA; Skachilova, SIa, 2014) |
| " When cancer cells are under regular culture condition, they show Warburg effect; whereas under lactic acidosis, they show a nonglycolytic phenotype, characterized by a high ratio of oxygen consumption rate over glycolytic rate, negligible lactate production and efficient incorporation of glucose carbon(s) into cellular mass." | 3.80 | Beyond Warburg effect--dual metabolic nature of cancer cells. ( Dai, C; Ding, Z; Hu, D; Hu, X; Ji, B; Luo, Y; Pan, Q; Wu, H; Xie, J, 2014) |
| "The objective of this study was to determine whether treatment with metformin in patients with renal impairment is associated with a higher risk of lactic acidosis or elevated lactate concentrations compared with users of a noninsulin antidiabetic drug (NIAD) who had never used metformin." | 3.80 | Risk of lactic acidosis or elevated lactate concentrations in metformin users with renal impairment: a population-based cohort study. ( De Smet, PA; de Vries, F; Derijks, HJ; Egberts, A; Eppenga, WL; Geerts, AF; Lalmohamed, A; Wensing, M, 2014) |
| "A 16-year-old perioperative paediatric patient presented with refractory lactic acidosis and multiorgan failure due to thiamine-deficient total parenteral nutrition during a recent national multivitamin shortage." | 3.80 | Severe lactic acidosis and multiorgan failure due to thiamine deficiency during total parenteral nutrition. ( Hartman, G; Mowbray, C; Pageler, N; Ramsi, M, 2014) |
| " Several patients with lactic acidosis and glucose levels below 1." | 3.80 | A patient with acute liver failure and extreme hypoglycaemia with lactic acidosis who was not in a coma: causes and consequences of lactate-protected hypoglycaemia. ( Gladden, LB; Goodwin, ML; McDonald, JR; Nijsten, MW; Oldenbeuving, G; Reijngoud, DJ; Sayilir, R, 2014) |
| "There is controversy surrounding the risk of metformin and the development of lactic acidosis." | 3.80 | Pharmacist review prevents evolving metformin-associated lactic acidosis. ( Kyle, G; Naunton, M; Naunton-Boom, K; Owoka, F, 2014) |
| "Lactic acidosis occurs in a number of clinical conditions, e." | 3.80 | Lactic acidosis treatment by nanomole level of spermidine in an animal model. ( Mirkhani, H; Sahmeddini, MA; Sattarahmady, N; Sedigh-Ardekani, M, 2014) |
| " The disorder is manifested by the appearance of hypoglycaemia, ketosis and lactic acidosis (neonatally or later during fasting or induced by fructose) and may also be life-threatening." | 3.80 | Fructose-1,6-diphosphatase deficiency: a treatable neurometabolic disorder. ( Gowda, P; Jambagi, M; Kamate, M; Sonoli, S, 2014) |
| "Lactic acidosis is an adverse event associated with metformin usage." | 3.79 | The Role of Metformin in Metformin-Associated Lactic Acidosis (MALA): Case Series and Formulation of a Model of Pathogenesis. ( Day, RO; Duong, JK; Furlong, TJ; Graham, GG; Greenfield, JR; Roberts, DM; Williams, KM, 2013) |
| " After an extensive workup, she was diagnosed with a rare clinical problem, D-lactic acidosis." | 3.79 | Formerly obese, now thin and confused: the utility of mnemonics in the approach to altered mental status. ( Burski, CM; Centor, RM; Miller, CS, 2013) |
| " We conclude that chronic DCA administration is generally well-tolerated in patients with congenital causes of lactic acidosis and is effective in maintaining normal blood lactate levels, even in PDC-deficient children not consuming strict ketogenic diets." | 3.79 | Long-term safety of dichloroacetate in congenital lactic acidosis. ( Abdelmalak, M; Coats, BS; Langaee, T; Lew, A; Neiberger, RE; Ramezani, R; Shankar, MN; Shroads, AL; Stacpoole, PW; Subramony, SH, 2013) |
| " It was found that the development of diabetes mellitus is associated with dramatic changes in the metabolism of blood cells and kidney tissue: inhibition of aerobic ATP synthesis, accumulation of lactate, uncoupling of oxidative phosphorylation, and development of lactic acidosis." | 3.79 | Dysfunction of membrane-receptor system of blood cells and kidney tissue in experimental diabetes mellitus. ( Gurina, AE; Mikaelian, NP; Terent'ev, AA, 2013) |
| " It frequently causes peripheral neuropathy and lipodystrophy and increases the risk of lactic acidosis and other high lactate syndromes." | 3.79 | Longitudinal lactate levels from routine point-of-care monitoring in adult Malawian antiretroviral therapy patients: associations with stavudine toxicities. ( Chagoma, N; Heyderman, RS; Kampira, E; Kaunda, S; Mallewa, J; Mukaka, M; Njalale, Y; van Oosterhout, JJ, 2013) |
| " Lactic acidosis, induced by the addition of 25 mm lactic acid, also induced the release of 20-kDa IL-1β." | 3.79 | Acidosis drives damage-associated molecular pattern (DAMP)-induced interleukin-1 secretion via a caspase-1-independent pathway. ( Allan, SM; Brough, D; Edye, ME; Lopez-Castejon, G, 2013) |
| "Lactic acidosis is a life-threatening complication of hemorrhagic shock." | 3.79 | Pyruvate Ringer's solution corrects lactic acidosis and prolongs survival during hemorrhagic shock in rats. ( Bai, XD; Fang, T; Hu, S; Liu, XQ; Wang, HB; Zhong, YX; Zhou, FQ, 2013) |
| "Hyperlactatemia and lactic acidosis are common in adults with acute severe asthma however only a few cases have been reported in children." | 3.78 | Mechanism of lactic acidosis in children with acute severe asthma. ( McCaulley, L; Meert, KL; Sarnaik, AP, 2012) |
| "Pyruvate dehydrogenase (PDH) deficiency is a major cause of primary lactic acidosis and neurological dysfunction in infancy and early childhood." | 3.78 | Unilateral periventricular leukomalacia in association with pyruvate dehydrogenase deficiency. ( Connolly, DJ; Mordekar, SR; Sharma, R; Sharrard, MJ, 2012) |
| "Lactic acidosis is common to most solid tumors and has been found to affect infiltrating immune cells." | 3.78 | Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation. ( Gottfried, E; Hu, B; Kreutz, M; Mendler, AN; Noessner, E; Prinz, PU, 2012) |
| " Metformin-associated lactic acidosis may sometimes be life-threatening." | 3.78 | Metformin-associated lactic acidosis following acute kidney injury. Efficacious treatment with continuous renal replacement therapy. ( Dahan, E; Dichtwald, S; Ekstein, MP; Sorkine, P; Weinbroum, AA, 2012) |
| "Perinatal antiretroviral (ARV) exposure has been related to hyperlactatemia and lactic acidosis in infants born to HIV-infected mothers." | 3.78 | Hyperlactatemia and in utero exposure to antiretrovirals: is the control group the clue? ( Arranz, JA; Espiau, M; Figueras, C; Martín-Nalda, A; Martínez-Gómez, X; Melendo, S; Riudor, E; Soler-Palacín, P, 2012) |
| "Lactic acidosis is a fatal adverse effect of metformin, but the risk factor remains unclear." | 3.78 | Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis. ( Fujimoto, S; Hosokawa, M; Inagaki, N; Inui, K; Katsura, T; Masuda, S; Osawa, R; Toyama, K; Yonezawa, A, 2012) |
| "Metformin therapy is limited in patients with chronic kidney disease (CKD) due to the potential risk of lactic acidosis." | 3.78 | Metformin therapy in patients with chronic kidney disease. ( Day, RO; Duong, JK; Furlong, TJ; Graham, GG; Greenfield, JR; Kirkpatrick, CM; Kumar, SS; Roberts, DM; Williams, KM, 2012) |
| "Hyperlactatemia and lactic acidosis (LA) are among the most dangerous and life-threatening side effect that occurs during therapy with some nucleoside reverse transcriptase inhibitors (NRTIs), mainly didanosine (ddI) and stavudine (d4T), also known as d-drugs." | 3.78 | The role of nucleoside reverse transcriptase inhibitors usage in the incidence of hyperlactatemia and lactic acidosis in HIV/AIDS patients. ( Dragovic, G; Jevtovic, D, 2012) |
| "Genetic factors play a role in the development of lactic acidosis after OLT." | 3.78 | The association of promoter gene polymorphisms of the tumor necrosis factor-α and interleukin-10 with severity of lactic acidosis during liver transplantation surgery. ( Abouelfetoh, F; Baz, H; Farahat, O; Labib, D; Mokhtar, A; Salah, M, 2012) |
| "Lactic acidosis in the absence of hypoxia or tissue hypoperfusion (type B) is very rare and is associated with the use of some drugs or malignancy." | 3.78 | [Type B lactic acidosis associated with marginal lymphoma of the spleen: report of one case]. ( Peña, A; Rodríguez, Mde L; Vásquez, A; Vega, J, 2012) |
| "The aim was to investigate whether the level of lactic acidosis in the first part of a heart rate-based lactate minimum test affects the lactate minimum heart rate and performance." | 3.78 | The level of lactic acidosis affects lactate minimum in a heart rate-based lactate minimum test. ( Labruyère, R; Perret, C, 2012) |
| "Lactic acidosis is a frequent cause of poor outcome in the intensive care settings." | 3.78 | Sodium bicarbonate treatment during transient or sustained lactic acidemia in normoxic and normotensive rats. ( Chevallard, G; Comi, GP; Coppola, S; Fortunato, F; Fossali, T; Froio, S; Gatti, S; Gattinoni, L; Pizzocri, M; Polli, F; Salice, V; Valenza, F, 2012) |
| "Literature review of cases of lymphoma with lactic acidosis, with and without hypoglycemia, demonstrated that these combinations occurred in multiple categories of B- and T-cell lymphoma." | 3.78 | "Hyper-warburgism," a cause of asymptomatic hypoglycemia with lactic acidosis in a patient with non-Hodgkin's lymphoma. ( Albert, SG; Elhomsy, GC; Eranki, V; Fesler, MJ; Griffing, GT; Michael, AG; Parker, SM, 2012) |
| " Laboratory findings showed hypokalemia, hypophosphatemia, and lactic acidosis." | 3.78 | Lactic acidosis following intentional overdose by inhalation of salmeterol and fluticasone. ( Hantson, P; Manara, A; Thys, F; Vanpee, D, 2012) |
| "Metformin has long been thought to cause lactic acidosis (LA) but evidence from various sources has led researchers to question a direct causative relationship." | 3.77 | Diabetes, metformin and lactic acidosis. ( Harvey, JN; Scale, T, 2011) |
| " In contrast, in Himalayan marmots treated with AZT we observed delayed toxicity, including lactic acidosis, severe hepatic steatosis, obvious mitochondrial damage, and significant decreases in respiratory chain complex enzyme activity and mtDNA content." | 3.77 | Evaluation of mitochondrial toxicity in Marmota himalayana treated with metacavir, a novel 2',3'-dideoxyguanosine prodrug for treatment of hepatitis B Virus. ( Chen, H; Hu, M; Jiang, Z; Li, Z; Tao, Y; Xiong, Y; Zhang, L; Zhang, P, 2011) |
| "D-lactic acidosis has been reported in patients after a variety of gastrointestinal surgeries, particularly jejunoileal bypass." | 3.77 | An extreme and life-threatening case of recurrent D-lactate encephalopathy. ( Htyte, N; Jones, J; Meisels, I; Sandhu, G; White, L, 2011) |
| " Two cases of lactic acidosis due to ingestion of high dose metformin for suicidal purposes have been presented here; in both cases, clinical improvement was seen with bicarbonate hemodialysis." | 3.77 | Dialysis therapy for lactic acidosis caused by metformin intoxication: presentation of two cases. ( Aytemiz, E; Begenik, H; Emre, H; Erkoc, R; Ozturk, M; Soyoral, YU, 2011) |
| "Lactic acidosis (LA) and severe hyperlactataemia (HL) are infrequent but serious complications of antiretroviral therapy that have been associated with a high fatality rate." | 3.77 | Risk factors for fatality in HIV-infected patients with dideoxynucleoside-induced severe hyperlactataemia or lactic acidosis. ( Arenas-Pinto, A; Bhaskaran, K; Carr, A; Copas, A; Dunn, D; Grant, A; Hoy, J; Martinez, E; Reiss, P; Weber, R; Weller, I; Worm, SW, 2011) |
| " The use of zidovudine instead of stavudine in higher-risk patients to reduce the likelihood of lactic acidosis and hyperlactatemia (LAHL) has not been examined." | 3.77 | A risk-factor guided approach to reducing lactic acidosis and hyperlactatemia in patients on antiretroviral therapy. ( Axten, K; Bangsberg, DR; Carver, E; Ewusi, A; Gandhi, RT; Geary, MC; Ghebremichael, M; Giddy, J; Guarino, AJ; Hampton, J; Matthews, LT, 2011) |
| "The reported incidence of metformin associated lactic acidosis (MALA) in type 2 diabetes mellitus (DM) is 3-9 cases per 100,000 patient-years." | 3.77 | Metformin associated lactic acidosis: incidence and clinical correlation with metformin serum concentration measurements. ( Doorenbos, CJ; van Berlo-van de Laar, IR; Vermeij, CG, 2011) |
| " His case was reviewed, and the lactic acidosis was thought to be caused by inhaled β2-agonist use." | 3.77 | Take my breath away: a case of lactic acidosis in an asthma exacerbation. ( McGonigle, R; Woods, RA, 2011) |
| "D-lactic acidosis occurs in ruminants, such as cattle, with acute ruminal acidosis caused by ingestion of excessive amounts of highly fermentable carbohydrates." | 3.77 | D-lactic acid interferes with the effects of platelet activating factor on bovine neutrophils. ( Alarcón, P; Burgos, RA; Carretta, MD; Concha, C; Conejeros, I; Hidalgo, MA; Jara, E; Tadich, N, 2011) |
| "Linezolid administration has been associated with lactic acidosis in adults; however, the same phenomenon has not been reported in children." | 3.77 | Linezolid and lactic acidosis: a role for lactate monitoring with long-term linezolid use in children. ( Carcillo, JA; Crowley, K; Michaels, MG; Su, E, 2011) |
| " Intoxication is associated with lactic acidosis and has significant clinical consequences." | 3.77 | Metformin intoxication requiring dialysis. ( Concepcion, L; Nguyen, HL, 2011) |
| "Symptomatic hyperlactataemia and lactic acidosis (SHLA) are potentially life-threatening complications associated with stavudine (d4T), an antiretroviral therapy (ART) drug widely used in developing countries." | 3.76 | Risk factors for and clinical characteristics of severe hyperlactataemia in patients receiving antiretroviral therapy: a case-control study. ( Boulle, A; Meintjes, G; Osler, M; Rebe, K; Stead, D, 2010) |
| " This agreement between glycolytic H+ production and elevation of lactate is confirmed by an analysis of the underlying reactions involved in glycolysis in vivo and supports the concept of lactic acidosis under conditions that substantially elevate lactate and drop pH." | 3.76 | Lactic acidosis in vivo: testing the link between lactate generation and H+ accumulation in ischemic mouse muscle. ( Conley, KE; Kushmerick, MJ; Marcinek, DJ, 2010) |
| "Diaspirin cross-linked hemoglobin (DCLHb) has demonstrated a pressor effect that could adversely affect traumatic hemorrhagic shock patients through diminished perfusion to vital organs, causing base deficit (BD) and lactate abnormalities." | 3.76 | Diaspirin cross-linked hemoglobin infusion did not influence base deficit and lactic acid levels in two clinical trials of traumatic hemorrhagic shock patient resuscitation. ( Gao, W; Koenigsberg, MD; Philbin, NB; Sloan, EP, 2010) |
| "Lactic acidosis has been considered to be a side effect of some biguanides, after phenformin was withdrawn from the market because of its association with lactic acidosis." | 3.76 | Comparison of potential risks of lactic acidosis induction by biguanides in rats. ( Bando, K; Deguchi, J; Funabashi, H; Kimura, J; Kunimatsu, T; Ochiai, S; Seki, T, 2010) |
| " In our study, the civilian device caused a mild lactic acidosis." | 3.76 | The cardiovascular, respiratory, and metabolic effects of a long duration electronic control device exposure in human volunteers. ( Dawes, DM; Ho, JD; Miner, JR; Reardon, RF, 2010) |
| "Lactic acidemia is one manifestation of the mitochondrial diseases caused by pathogenic mutant mitochondrial DNA (mtDNA)." | 3.76 | Lactic acidemia in the pathogenesis of mice carrying mitochondrial DNA with a deletion. ( Hayashi, J; Nakada, K; Ogasawara, E, 2010) |
| "d-Lactic acidosis is associated with memory impairment in humans." | 3.76 | Increased plasma d-lactic acid associated with impaired memory in rats. ( Clayton, EH; Hanstock, TL; Mallet, PE, 2010) |
| "Lactic acidosis causes atrial fibrillation (AF), and pulmonary veins (PVs) are the most important focus for the generation of AF." | 3.75 | Cariporide (HOE642) attenuates lactic acidosis induced pulmonary vein arrhythmogenesis. ( Chen, SA; Chen, YC; Chen, YJ; Cheng, CC; Higa, S; Udyavar, AR, 2009) |
| "Lactic acidosis is considered an early sign of propofol infusion syndrome." | 3.75 | Prolonged propofol anesthesia is not associated with an increase in blood lactate. ( Lam, AM; Lee, LA; Rozet, I; Tontisirin, N; Treggiari, MM; Vavilala, MS, 2009) |
| " However, the acute effects of these repeated sprint sequences on lactic acidosis and resulting autonomic state perturbation are not known." | 3.75 | Cardiac autonomic responses to repeated shuttle sprints. ( Buchheit, M; Laursen, PB; Leme, LC; Nakamura, FY; Polito, MD; Soares-Caldeira, LF, 2009) |
| "The relationship among metformin use, plasma lactate levels, and lactic acidosis in patients with type 2 diabetes mellitus and the appropriateness of metformin use in patients with renal dysfunction are discussed." | 3.75 | Metformin use in renal dysfunction: is a serum creatinine threshold appropriate? ( Ernst, ME; McDanel, DL; Moores, KG; Philbrick, AM; Ross, MB, 2009) |
| " In resource-poor settings it is difficult to definitively diagnose lactic acidosis by laboratory measurement of lactate." | 3.74 | Validation of the Accutrend lactate meter for hyperlactatemia screening during antiretroviral therapy in a resource-poor setting. ( Bizaare, M; Chetty, U; Dawood, H; Esterhuizen, TM; Pérez, EH, 2008) |
| "Female gender should be carefully monitored with respect to their clinical, laboratory and biological data to diminish the occurrence of lactic acidosis." | 3.74 | Co-factors for abnormal lactate levels among persons with HIV disease at a tertiary HIV care setting in South India. ( Balakrishnan, P; Deepak, M; Kumarasamy, N; Murugavel, KG; Shankar, EM; Solomon, S; Srinivas, CN; Sundaram, M, 2008) |
| " In conclusion, no thiamine deficiency was noted in patients with normal anion gap, but thiamine deficiency was not uncommon in patients with a wide anion gap, regardless of lactic acidosis." | 3.74 | A preliminary study of thiamine status in northeastern Thai children with acute diarrhea. ( Boonsiri, P; Panthongviriyakul, C; Tangrassameeprasert, R; Yongvanit, P, 2007) |
| "As a class, the biguanides induce lactic acidosis, a hallmark of mitochondrial impairment." | 3.74 | Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro. ( Billis, PA; Dykens, JA; Jamieson, J; Marroquin, L; Nadanaciva, S; Will, Y, 2008) |
| "To compare the prognostic abilities of lactic acidosis and hyperlactatemia and determine the influence of metabolic acidosis when attempting to predict the outcome of septic patients using serum lactate levels." | 3.74 | Lactic acidosis not hyperlactatemia as a predictor of in hospital mortality in septic emergency patients. ( Baek, KJ; Choi, SH; Hong, YS; Kim, JY; Lee, SW; Moon, SW; Park, DW; Park, JS, 2008) |
| "Lactic acidosis is an integral index of metabolic disturbances and severity of inflammation processes." | 3.74 | [Clinical implications of lactic acidosis in purulent meningitis]. ( Chentsov, VB; Menushenkova, SA; Migmanov, TE; Molotilova, TN; Nagibina, MV; Vengerov, IuIa, 2008) |
| "Lactic acidosis is a common problem in the peri-operative period." | 3.74 | Augmented serum lactic acid combined with metabolic alkalosis: a case report. ( Jacobs, TF; Niewold, C; Szegedi, LL, 2008) |
| " At a target pressure of 40 mmHg, the initial blood pressure response to oxygen is the same, but it gradually decreases as the animal develops a lactic acidosis." | 3.74 | Cardiovascular responses to oxygen inhalation after hemorrhage in anesthetized rats: hyperoxic vasoconstriction. ( Atkins, JL; Johnson, KB; Pearce, FJ, 2007) |
| "To determine whether lactic acidosis at birth in asphyxiated neonates could predict the grade of EEG encephalopathy by examining the relationship between time taken for the normalisation of lactate, severity of encephalopathy and seizure burden." | 3.74 | Persistent lactic acidosis in neonatal hypoxic-ischaemic encephalopathy correlates with EEG grade and electrographic seizure burden. ( Boylan, GB; Connolly, S; Fitzgerald, AP; Murphy, BP; Murray, DM; Ryan, CA, 2008) |
| "Although the blood lactate-to-pyruvate (L:P) molar ratio is used to distinguish between pyruvate dehydrogenase deficiency (PDH-D) and other causes of congenital lactic acidosis (CLA), its diagnostic accuracy for differentiating between these 2 types of CLA has not been evaluated formally." | 3.74 | Diagnostic accuracy of blood lactate-to-pyruvate molar ratio in the differential diagnosis of congenital lactic acidosis. ( Allard, P; Debray, FG; Hanley, JA; Lambert, M; Mitchell, GA; Robinson, BH, 2007) |
| "Lactic acidosis (DAC) occurs as a complication of short-bowel syndrome in humans and in a variety of other gastrointestinal disorders in monogastrics and ruminants." | 3.74 | D-Lactic acid-induced neurotoxicity in a calf model. ( Abeysekara, S; Isak, U; Naylor, JM; Wassef, AW; Zello, GA, 2007) |
| " Measurement of pH in cerebrospinal fluid (CSF) yielded central lactic acidosis despite alkalosis in peripheral blood." | 3.74 | Central lactic acidosis, hyperventilation, and respiratory alkalosis: leading clinical features in a 3-year-old boy with malignant meningeal melanoma. ( Bierbach, U; Blüher, S; Hirsch, W; Kiess, W; Meixensberger, J; Schober, R; Schulz, M; Siekmeyer, W; Tröbs, RB, 2008) |
| "The goals of this work were first to assess whether the lactic acidosis observed in vivo in ischemia may by itself explain the inhibition of protein synthesis described in the literature and second to study the factors controlling the initiation of protein synthesis under lactic acid stress." | 3.74 | Regulation of initiation factors controlling protein synthesis on cultured astrocytes in lactic acid-induced stress. ( Barrier, L; Fauconneau, B; Guillard, O; Ingrand, S; Page, G; Pain, S; Piriou, A; Rioux-Bilan, A; Vantelon, N, 2007) |
| "Patients had net metabolic acidosis owing to unmeasured anions and owing to hyperchloraemic, dilutional and lactic acidosis." | 3.74 | Acid-base disturbances in critically ill patients with cirrhosis. ( Doberer, D; Funk, GC; Holzinger, U; Kneidinger, N; Lindner, G; Schneeweiss, B, 2007) |
| " Lactic acidosis is a clinically important metabolic condition accompanying various tissue disorders in which the extracellular pH and the intracellular pH often change in parallel." | 3.74 | Early and late activation of the voltage-gated proton channel during lactic acidosis through pH-dependent and -independent mechanisms. ( Kawawaki, J; Kuno, M; Morihata, H; Notomi, T; Okina, M; Sakai, H; Sawada, M, 2008) |
| "This study demonstrates that exogenous ADM prevents and reverses hypodynamic circulation, attenuates pulmonary hypertension, and limits lactic acidosis in ovine endotoxaemia." | 3.74 | Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia. ( Booke, M; Ertmer, C; Hucklenbruch, C; Lange, M; Morelli, A; Rehberg, S; Van Aken, H; Westphal, M, 2007) |
| " An increased lactate level was found in asphyctic infants and a clear correlation between lactic acidosis and foetal distress was documented." | 3.74 | Prevention of cerebral palsy during labour: role of foetal lactate. ( Borruto, F; Comparetto, C; Treisser, A, 2008) |
| " Forty-two percent of nonsurvivors had normal lactate levels, whereas 33% of survivors had lactic acidosis." | 3.74 | Comparison of acid-base models for prediction of hospital mortality after trauma. ( Kaplan, LJ; Kellum, JA, 2008) |
| " Extracellular pH defense against lactic acidosis was estimated from changes (Delta) in lactic acid ([La]), [HCO3-], pH and PCO2 in plasma, which equilibrates with interstitial fluid." | 3.74 | Extracellular pH defense against lactic acid in untrained and trained altitude residents. ( Böning, D; Coy, L; Mora, M; Reyes, O; Rojas, J; Serrato, M, 2008) |
| "d-lactic acidosis is a rare and severe complication of short bowel syndrome in children that may result from important ileal bacterial overgrowth by lactobacilli." | 3.74 | [D-lactic acidosis in a child with short bowel syndrome]. ( Dahhak, S; Fontaine, M; Gottrand, F; Mention, K; Michaud, L; Romond, MB; Turck, D; Uhlen, S, 2008) |
| "Mitochondrial myopathies are heterogeneous disorders with diverse presentations including laboratory findings of lactic acidosis." | 3.74 | Severe lactic acidosis secondary to minocycline in a teenager with infectious mononucleosis and mitochondrial myopathy. ( Rison, RA; Zoraster, RM, 2008) |
| " Other metabolic abnormalities, including hypernatremia, hyponatremia, low ionized calcium and magnesium levels, and lactic acidosis may contribute to muscle fatigue and collapse." | 3.74 | Cardiac biomarkers, electrolytes, and other analytes in collapsed marathon runners: implications for the evaluation of runners following competition. ( Januzzi, J; Lee-Lewandrowski, E; Lewandrowski, KB; Shirey, T; Siegel, AJ; Sluss, P; Wood, M, 2008) |
| " It could be proposed that patients having one or more of these risk factors undergo regular monitoring of plasma lactate and renal function to prevent lactic acidosis." | 3.73 | Risk factors for hyperlactataemia in HIV-infected patients, Aquitaine Cohort, 1999--2003. ( Balestre, E; Bernardin, E; Bonnet, F; Dabis, F; Neau, D; Pellegrin, JL, 2005) |
| " He developed a marked lactic acidosis with mild biological signs of renal impairment and rhabdomyolysis but no cardiocirculatory failure." | 3.73 | Propofol infusion syndrome associated with short-term large-dose infusion during surgical anesthesia in an adult. ( Guérit, JM; Hantson, P; Liolios, A; Raftopoulos, C; Scholtes, JL, 2005) |
| "We intended to find out the effectiveness of lactic acidosis therapy for mitochondrial toxicity." | 3.73 | [Treatment of symptomatic hyperlactatemia and lactic acidosis in HIV+ patients under nucleoside reverse transcriptase inhibitors]. ( Deig, E; Garrabou, G; Miró, O; Pedrol, E; Ribell, M; Soler, A; Villà, Mdel C, 2005) |
| "Lactic acidosis is a rare but life-threatening complication of combination antiretroviral therapy (CART)." | 3.73 | Risk factors for and outcome of hyperlactatemia in HIV-infected persons: is there a need for routine lactate monitoring? ( Günthard, HF; Haupts, S; Imhof, A; Ledergerber, B; Weber, R, 2005) |
| " We recently encountered a patient with a mysterious lactic acidosis." | 3.73 | Lactate in a laubenpieper. ( Claus, T; Derer, W; Elitok, S; Kettritz, R; Luft, FC; Pilz, B; Ruf, R; Schütt, H, 2005) |
| " This is largely due to the historical experience of lactic acidosis with phenformin, despite the fact that metformin does not predispose to this when compared with other therapies." | 3.73 | Contraindications can damage your health--is metformin a case in point? ( Holstein, A; Stumvoll, M, 2005) |
| " Caenorhabditis elegans strains with complex I mutations exhibit characteristic features of human mitochondrial disease including decreased rates of respiration and lactic acidosis." | 3.73 | Introduction of an additional pathway for lactate oxidation in the treatment of lactic acidosis and mitochondrial dysfunction in Caenorhabditis elegans. ( Grad, LI; Lemire, BD; Sayles, LC, 2005) |
| "Lactic acidosis portends a poor prognosis in trauma, sepsis, and other shock states and is useful for triaging and resuscitating emergency department (ED) patients." | 3.73 | The anion gap does not accurately screen for lactic acidosis in emergency department patients. ( Adams, BD; Bonzani, TA; Hunter, CJ, 2006) |
| " An increased lactate level was found in asphyctic infants and a clear correlation between lactic acidosis and foetal distress was documented." | 3.73 | Screening of foetal distress by assessment of umbilical cord lactate. ( Borruto, F; Comparetto, C; Treisser, A; Wegher, E, 2006) |
| " Only one case experienced lactic acidosis and died during follow-up." | 3.72 | Prevalence, risk factors and outcome of hyperlactataemia in HIV-infected patients. ( Alberti, C; Bagnard, G; Carel, O; Erlich, D; Feugeas, JP; Hocqueloux, L; Lafaurie, M; Lukasiewicz, E; Molina, JM, 2003) |
| " D-lactic acidosis was diagnosed on the basis of a D-lactate level of 5." | 3.72 | D-lactic acidosis secondary to short bowel syndrome. ( Cao, B; Jiang, J; Jiang, ZW; Li, JS; Zhang, DL, 2003) |
| "Biguanides are a class of drugs widely used as oral antihyperglycemic agents for the treatment of type 2 diabetes mellitus, but they are associated with lactic acidosis, a lethal side effect." | 3.72 | Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin. ( Jonker, JW; Kato, Y; Kusuhara, H; Schinkel, AH; Sugiyama, Y; Wang, DS, 2003) |
| "Lactic acidosis in patients infected with the human immunodeficiency virus was initially identified as a rare complication of therapy with nucleoside analog reverse transcriptase inhibitors (NRTIs)." | 3.72 | Lactic acidemia in infection with human immunodeficiency virus. ( Carr, A, 2003) |
| "Lactic acidosis has been reported as a complication associated with antiretroviral therapy; in particular, usually with use of nucleoside reverse-transcriptase inhibitors." | 3.72 | Human immunodeficiency virus infection with human granulocytic ehrlichiosis complicated by symptomatic lactic acidosis. ( Altice, FL; Springer, SA, 2003) |
| " The frequencies of hyperlactatemia and lactic acidosis were determined, and the risk factors were analyzed by a multivariate logistic regression model." | 3.72 | Frequency, risk factors, and outcome of hyperlactatemia in HIV-positive persons: implications for the management of treated patients. ( Beytout, J; Cormerais, L; Dastugue, B; Jacomet, C; Laurichesse, H; Marceau, G; Peigue-Lafeuille, H; Regagnon, C; Sapin, V; Ughetto, S, 2003) |
| "In type II diabetes treated with metformin, lactic acidosis is a rare but severe complication." | 3.72 | [Metformin-associated lactic acidosis precipitated by acute renal failure]. ( Azoulay, E; Galy-Floc'h, M; Mariot, J; Pertek, JP; Vidal, S, 2003) |
| "We report 4 cases of lactic acidosis in diabetic patients usually treated with metformin." | 3.72 | [Metformin-associated lactic acidosis remains a serious complication of metformin therapy]. ( Giunti, C; Grimaud, D; Ichai, C; Levraut, J; Orban, JC, 2003) |
| " We conclude that caiman osteoderms sequester lactate during lactic acidosis and that the time course is fast enough to have benefit to these animals following normal anaerobic burst activity." | 3.72 | Lactate sequestration by osteoderms of the broad-nose caiman, Caiman latirostris, following capture and forced submergence. ( Abe, AS; Andrade, DV; Jackson, DC, 2003) |
| " The animals developed severe lactic acidosis between 30 and 90 min, which was accompanied by a trend for initial rise and subsequent 40% drop of CH50/mL, indicating massive C activation even before resuscitation, i." | 3.72 | Complement activation during hemorrhagic shock and resuscitation in swine. ( Alving, CR; Baranyi, L; Bünger, R; Götze, O; Mongan, PD; Savay, S; Szebeni, J, 2003) |
| "Hyperlactatemia and lactic acidosis occur in HIV-infected adults receiving antiretroviral treatment." | 3.72 | Hyperlactatemia in human immunodeficiency virus-infected children receiving antiretroviral treatment. ( Artuch, R; Fortuny, C; Jiménez, R; Muñoz-Almagro, C; Noguera, A; Pou, J; Sanchez, E; Vilaseca, MA, 2003) |
| "Lactic acidosis is a life-threatening event during antiretroviral therapy (ART)." | 3.72 | Matched case-control study to evaluate risk factors for hyperlactataemia in HIV patients on antiretroviral therapy. ( Datta, D; Gazzard, B; Mandalia, S; Moyle, G, 2003) |
| "Lactic acidosis is a feared side effect of nucleoside analog treatment, one of the cornerstones in the management of HIV infection." | 3.72 | Preanalytical handling of samples for measurement of plasma lactate in HIV patients. ( Andersen, O; Haugaard, SB; Iversen, J; Jørgensen, LT; Madsbad, S; Nielsen, JO; Sørensen, S, 2003) |
| "We describe the case of a 7-year-old boy with osteogenesis imperfecta, who underwent anaesthesia with propofol-fentanyl-nitrous oxide-suxamethonium for orthopaedic surgery of a distal femur fracture." | 3.72 | Lacticacidosis after short-term infusion of propofol for anaesthesia in a child with osteogenesis imperfecta. ( Kill, C; Leonhardt, A; Wulf, H, 2003) |
| "An 11-month-old girl with B-cell leukemia/lymphoma developed profound lethargy due to severe lactic acidosis during chemotherapy and total parenteral nutrition (TPN)." | 3.72 | Severe lactic acidosis due to thiamine deficiency in a patient with B-cell leukemia/lymphoma on total parenteral nutrition during high-dose methotrexate therapy. ( Calvillo, M; Caruso, U; Dufour, C; Minniti, G; Schiaffino, MC; Svahn, J, 2003) |
| " The initial patient, and later her newborn sibling, had mildly dysmorphic features, lactic acidosis and a defect in mitochondrial respiratory complex II associated with many biochemical features of a block in fatty acid oxidation." | 3.72 | Respiratory complex II defect in siblings associated with a symptomatic secondary block in fatty acid oxidation. ( Bocian, M; Boyle, K; Gargus, JJ; Roe, CR; Roe, DS; Vianey-Saban, C, 2003) |
| "Lactic acidosis is a rare but potentially life-threatening and poorly understood sequelae among HIV-infected patients on highly active antiretroviral therapy (HAART)." | 3.72 | Highly active antiretroviral therapy (HAART)-associated lactic acidosis: in vitro effects of combination of nucleoside analogues and protease inhibitors on mitochondrial function and lactic acid production. ( Frank, JE; Nerurkar, PV; Nerurkar, VR; Pearson, L; Yanagihara, R, 2003) |
| "Myometrial lactic acidosis and a small decrease in O(2) saturation may be contributing factors to dysfunctional labor." | 3.72 | Dysfunctional labor and myometrial lactic acidosis. ( Brigham, S; Pierce, SJ; Quenby, S; Wray, S, 2004) |
| "During constant work-rate exercise above the lactic acidosis threshold, oxygen consumption fails to plateau by 3 minutes, but continues to rise slowly." | 3.72 | Gas exchange responses to constant work-rate exercise in patients with glycogenosis type V and VII. ( Lovell, S; Nicholls, DP; O'Dochartaigh, CS; Ong, HY; Patterson, VH; Riley, MS; Wasserman, K, 2004) |
| "Lactic acidosis is a life-threatening complication of antiretroviral therapy with an incidence of about 1% per year." | 3.72 | [Lactic acidosis in HIV-patients--diagnosis and treatment]. ( Walker, UA, 2004) |
| " Initial investigations demonstrated a severe lactic acidosis." | 3.72 | Severe lactic acidosis following alcohol related generalised seizures. ( Hulme, J; Sherwood, N, 2004) |
| "To evaluate the prevalence, outcome and possible risk factors for hyperlactataemia and lactic acidosis in HIV-positive persons receiving antiretroviral therapy." | 3.71 | Hyperlactataemia and lactic acidosis during antiretroviral therapy: relevance, reproducibility and possible risk factors. ( Asboe, D; Datta, D; Gazzard, BG; Mandalia, S; Morlese, J; Moyle, GJ, 2002) |
| " mtDNA depletion may contribute to lactic acidosis, steatohepatitis and liver failure." | 3.71 | Increased long-term mitochondrial toxicity in combinations of nucleoside analogue reverse-transcriptase inhibitors. ( Setzer, B; Venhoff, N; Walker, UA, 2002) |
| "Long-term treatment with nucleoside reverse transcriptase inhibitors (NRTIs) can induce mitochondrial dysfunction, most severely represented by lactic acidosis." | 3.71 | Hyperlactataemia in HIV-infected patients: the role of NRTI-treatment. ( Brinkman, K; Frissen, PH; Regez, RM; Smulders, YM; Treskes, M; Troost, N; Vrouenraets, SM; Weigel, HM, 2002) |
| "Type B lactic acidosis is rare among patients with malignant diseases." | 3.71 | Multiple myeloma associated with lactic acidosis. ( Burgess, R; Dainer, P; Fall, P; Hendricks, L; Jillella, A; Szerlip, HM; Ustun, C, 2002) |
| " Thus, continuous parenteral infusion of glucose solution at an early stage after exposure may be an effective clinical therapy for the prevention of hypoglycaemia and metabolic lactic acidosis caused by MCA." | 3.71 | Therapeutic effects of glucose infusion on monochloroacetic acid exposure in rats. ( Dote, T; Furuya, E; Kato, J; Kono, K; Sakai, A; Shimizu, H; Toshina, Y; Usuda, K, 2002) |
| "In 516 patient-years of observation, two patients experienced severe fulminant lactic acidosis (lactate > 5 mmol/l) and hepatic steatosis attributable to nucleoside analogue reverse transcriptase inhibitors (NRTI)." | 3.71 | Chronic hyperlactatemia in HIV-infected patients taking antiretroviral therapy. ( James, IR; John, M; Mallal, SA; McKinnon, EJ; Moore, CB; Nolan, D; Upton, RP, 2001) |
| "Dobutamine increased resting O(2) and O(2) at the lactic acidosis threshold (LAT) but not peak O(2)." | 3.71 | Effects of dobutamine on critical capillary PO(2) and lactic acidosis threshold in patients with cardiovascular disease. ( Adachi, H; Hiroe, M; Itoh, H; Kobayashi, K; Koike, A; Shimizu, N; Wasserman, K, 2001) |
| "05) protected from lactic acidosis, glutamate buildup, and diminished HCO(3)(-) levels." | 3.71 | CD8(+)-T-cell depletion ameliorates circulatory shock in Plasmodium berghei-infected mice. ( Chang, WL; Granger, DN; Huang, J; Jones, SP; Lefer, DJ; Sun, G; Suzuki, H; van der Heyde, HC; Welbourne, T; Yin, L, 2001) |
| " The diagnosis of pyruvate dehydrogenase deficiency was made in the presenting fetus after delivery on the basis of subsequent mortality from severe lactic acidosis." | 3.71 | Prenatal diagnosis of pyruvate dehydrogenase deficiency using magnetic resonance imaging. ( Brown, SA; Mulkern, R; Norwitz, ER; Robinson, JN; Rybicki, F; Tempany, CM, 2001) |
| "Lactic acidosis (LAc) is a common form of metabolic acidosis early after heart transplantation (HTX)." | 3.71 | Lactic acidosis following heart transplantation: a common phenomenon? ( Carrel, T; Hullin, R; Mohacsi, P; Pedrazzinia, G; Tanner, H; Tschanz, HU, 2002) |
| " Lactic acidosis, characterized by metabolic acidosis, blood lactate above 5 mmol/l, hepatic steatosis and high mortality, represents the extreme end of this spectrum where there is complete decompensation." | 3.71 | Hyperlactatemia syndromes in people with HIV infection. ( John, M; Mallal, S, 2002) |
| "Premature lactic acidosis during exercise in patients with chronic obstructive pulmonary disease (COPD) may play a role in exercise intolerance." | 3.70 | Metabolic and hemodynamic responses of lower limb during exercise in patients with COPD. ( Bélanger, M; Bernard, S; Desmeules, M; Jobin, J; Killian, KJ; LeBlanc, P; Maltais, F; Sullivan, MJ; Whittom, F, 1998) |
| " immature brain, and may reflect differences in the extent or duration of cerebral lactic acidosis." | 3.70 | Maturational changes in cerebral lactate and acid clearance following ischemia measured in vivo using magnetic resonance spectroscopy and microdialysis. ( Corbett, R; Garcia, D; Kim, B; Laptook, A; Silmon, S; Tollefsbol, G, 1999) |
| " Lactic acidosis is exceptionally associated to this allergy." | 3.70 | [Severe lactic acidosis disease disclosing milk-protein intolerance to cows' milk]. ( Ogier de Baulny, H; Olivier, C; Rizk, C; Saudubray, JM; Valdes, L, 1999) |
| "The antidiabetic drug metformin has been associated in a small number of patients with lactic acidosis, a serious condition with a poor prognosis." | 3.70 | Lactic acidosis in metformin-treated patients. Prognostic value of arterial lactate levels and plasma metformin concentrations. ( Lalau, JD; Race, JM, 1999) |
| "Hemorrhagic shock is associated with lactic acidosis and increased plasma catecholamines." | 3.70 | Adrenergic antagonists reduce lactic acidosis in response to hemorrhagic shock. ( Frame, SB; Friend, LA; James, JH; Luchette, FA; McCarter, F; Robinson, BR, 1999) |
| " Thus muscle deoxygenation observed in the present study from 60-65% of VO(2 peak) could be attributed to capillary-venular Hb desaturation in the presence of relatively constant capillary-venular PO(2) levels, as a consequence of a rightward shift of the O(2)Hb dissociation curve determined by the onset of lactic acidosis." | 3.70 | Blood lactate accumulation and muscle deoxygenation during incremental exercise. ( Cerretelli, P; Ferrari, M; Grassi, B; Marconi, C; Quaresima, V, 1999) |
| "The present study was designed to investigate the efficacy of control of lactic acidosis by immunisation against lactic acid-producing bacteria, Streptococcus bovis and Lactobacillus." | 3.70 | Immunisation against lactic acidosis in cattle. ( Bird, SH; Gill, HS; Hennessy, DW; Leng, RA; Rowe, JB; Shu, Q, 1999) |
| "Oxidative phosphorylation of isolated rat skeletal muscle mitochondria after exposure to lactic acidosis in either phosphorylating or nonphosphorylating states has been evaluated." | 3.70 | Actively phosphorylating mitochondria are more resistant to lactic acidosis than inactive mitochondria. ( Sahlin, K; Tonkonogi, M, 1999) |
| "Glycolate causes large artifactual elevations in plasma L-lactate measurements by two analyzers in common use, with potential for misdiagnosis of lactic acidosis in ethylene glycol poisoning." | 3.70 | Artifactual elevation of measured plasma L-lactate concentration in the presence of glycolate. ( Clague, A; Clark, C; Morgan, TJ, 1999) |
| " Lactic acidosis and poor cardiac performance, as evidenced by low cardiac index (CI) with normal filling pressures, were seen in all cases of MSOF and RC, as well as in all deaths." | 3.70 | The golden hour and the silver day: detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma. ( Blow, O; Butler, K; Claridge, JA; Magliore, L; Young, JS, 1999) |
| "The biguanide drugs metformin and phenformin have been linked in the past to lactic acidosis, a metabolic condition associated with high rates of mortality." | 3.70 | Lactic acidosis in metformin therapy. ( Lalau, JD; Race, JM, 1999) |
| "Sixty consecutive adult patients who developed septic shock and lactic acidosis requiring the administration of vasopressors." | 3.70 | Evolution of lactate/pyruvate and arterial ketone body ratios in the early course of catecholamine-treated septic shock. ( Bollaert, PE; Gelot, AM; Larcan, A; Levy, B; Nabet, P; Sadoune, LO, 2000) |
| "In septic shock, the extent to which lactic acidosis (LA) is a consequence of splanchnic lactate overproduction (SLP) or impaired hepatic lactate extraction (HLE) is not clear." | 3.70 | Impaired hepatic extraction and increased splanchnic production contribute to lactic acidosis in canine sepsis. ( Bands, C; Bautista, E; Bose, D; Chrusch, C; Duke, K; Eschun, G; Jacobs, H; Li, X; Light, RB; Mink, SN, 2000) |
| " These results indicate that animals may develop a considerable lactic acidosis during a winter in which temperatures fall below 0 degree C for weeks or months and that accumulation of lactate may contribute to mortality of overwintering animals." | 3.70 | Accumulation of lactate by supercooled hatchlings of the painted turtle (Chrysemys picta): implications for overwinter survival. ( Hartley, LM; Packard, GC; Packard, MJ, 2000) |
| "The purpose of this study was to determine whether oxygenation in localized working muscle depended on the muscle activity and on the lactic acidosis level." | 3.70 | Relationship among oxygenation, myoelectric activity, and lactic acid accumulation in vastus lateralis muscle during exercise with constant work rate. ( Araki, H; Kitagawa, K; Matoba, H; Miura, H, 2000) |
| " Hyperlactatemia with L/P ratio elevation and lactic acidosis is likely to be associated with inadequate tissue perfusion." | 3.70 | Time-pattern of lactate and lactate to pyruvate ratio in the first 24 hours of intensive care emergency admissions. ( Kari, A; Ruokonen, E; Suistomaa, M; Takala, J, 2000) |
| "64) l x min(-1)] and mean VO2 at lactic acidosis threshold [LAT, 0." | 3.70 | Gas exchange responses to continuous incremental cycle ergometry exercise in primary pulmonary hypertension in humans. ( Brundage, BH; Engelen, MP; Pórszász, J; Riley, MS; Wasserman, K, 2000) |
| "Patients with tissue perfusion deficit usually have lactic acidosis or hyperlactacidemia and blood lactate level has been used to diagnose this condition and to monitor the disease progression." | 3.70 | Blood lactate determined by a portable device in critically ill patients. ( Neungton, N; Permpikul, C; Ratanarat, R, 2000) |
| "Microbial and fermentation changes in the ingesta of the large intestine and their influence on the pathogenesis of acute lactic acidosis were studied in 4 cows fitted with permanent cannulas in the ileum and cecum." | 3.70 | [Impact of lactic acid fermentation in the large intestine on acute lactic acidosis in cattle]. ( Pestevsek, U; Vengust, A; Zust, J, 2000) |
| " Lactic acidosis induced by exercise increases the stress on the ventilatory system due to CO2 generated by bicarbonate buffering and hydrogen ion stimulation." | 3.69 | Contribution of the respiratory muscles to the lactic acidosis of heavy exercise in COPD. ( Carithers, E; Casaburi, R; Engelen, MP; Rucker, R, 1995) |
| "To report the clinical history and laboratory evaluation of a patient presenting with lactic acidosis secondary to pyruvate carboxylase deficiency." | 3.69 | Prolonged survival in pyruvate carboxylase deficiency: lack of correlation with enzyme activity in cultured fibroblasts. ( Depalma, L; Nayar, R; Rifai, N; Stern, HJ, 1995) |
| " Parallel to these changes, systemic lactic acidosis developed." | 3.69 | Detection of liver ischemia using microdialysis during experimental peritonitis in pigs. ( Haglund, U; Hillered, L; Rasmussen, I; Ungerstedt, U, 1994) |
| "D-Lactic acidosis is an unique complication of jejunoileal bypass occurring because of alteration of colonic bacterial flora with selective proliferation of D-lactate-producing bacteria." | 3.69 | D-lactic acidosis in a patient with jejunoileal bypass. ( Kadakia, SC, 1995) |
| " Above the anaerobic threshold, accelerated glycolysis increases muscle lactic acidosis." | 3.69 | Determination of the anaerobic threshold by gas exchange: biochemical considerations, methodology and physiological effects. ( Casaburi, R; Cooper, CB; Koike, A; Stringer, WW; Wasserman, K, 1994) |
| "The present study was designed to determine whether lactate changes the critical pH point at which the recovery of rat population spike is inhibited following glucose-oxygen deprivation and second, which degree of lactic acidosis is similar to the effect of CO2 acidosis." | 3.69 | Effect of lactic and CO2 acidosis on neuronal function following glucose-oxygen deprivation in rat hippocampal slices. ( Kemmotsu, O; Morimoto, Y, 1994) |
| "5-7 m/s), the Arabian mare showed a marked lactic acidosis, increased mixed venous PVO2, and little change in oxygen consumption." | 3.69 | Skeletal muscle mitochondrial myopathy as a cause of exercise intolerance in a horse. ( Birks, EK; Cardinet, GH; Carlson, GP; Chomyn, A; DiMauro, S; Jones, JH; Valberg, SJ, 1994) |
| "Ethanol intoxication has been widely reported as a cause of lactic acidosis." | 3.69 | Lactic acidosis and acute ethanol intoxication. ( Kruse, JA; Levy, DB; MacDonald, L; Marulendra, S; Sweeny, PJ, 1994) |
| "A 6-month-old female infant with hypotonia and keto and lactic acidosis was diagnosed with lipoamide dehydrogenase (E3) deficiency." | 3.69 | Leigh disease with deficiency of lipoamide dehydrogenase: treatment failure with dichloroacetate. ( Craigen, WJ, 1996) |
| "The goal of this study was to evaluate whether sodium bicarbonate might be a useful form of therapy for hypoxic L-lactic acidosis; our aim was to determine if alkali could extend the time of survival in this setting." | 3.69 | Alkali therapy extends the period of survival during hypoxia: studies in rats. ( Cheema-Dhadli, S; Chen, CB; Halperin, FA; Halperin, ML, 1996) |
| "A hemodialysed patient with abdominal pain, severe lactic acidosis and prolonged hypoglycemia is described." | 3.69 | Acute necrotizing pancreatitis, lactic acidosis and prolonged hypoglycemia in a hemodialysed patient--a logical but unfortunately fatal combination. ( Chagnac, A; Gafter, U; Halperin, M; Korzets, A; Ori, Y; Weinstein, T; Zevin, D, 1996) |
| " Lactic acidosis occurred in 8 septic patients irrespective of the substitution fluid." | 3.69 | Comparison of a lactate-versus acetate-based hemofiltration replacement fluid in patients with acute renal failure. ( Grabensee, B; Heering, P; Heintzen, M; Manassa, E; Morgera, S; Passlick-Deetjen, J; Szentandrasi, T; Willers, R, 1997) |
| "Previously, we have demonstrated that short bowel syndrome (SBS) patients suffer daily from D-lactic acidemia; in these patients rather high amounts of (bacterial) D-lactate emerge in blood and urine with a circadian rhythm." | 3.69 | Role of bacteria in the pathogenesis of short bowel syndrome-associated D-lactic acidemia. ( Bakkeren, JA; Bongaerts, GP; Naber, AH; Severijnen, RS; Sperl, WJ; Tolboom, JJ; Willems, JL, 1997) |
| "With the same degree of lactic acidosis (blood lactate concentration of 52 mmol/L), the position of the oxyhemoglobin dissociation curve was the same for blood with PCO2 of 30 torr (4 kPa) and pH of 6." | 3.69 | Effect of extreme metabolic acidosis on oxygen delivery capacity of the blood--an in vitro investigation of changes in the oxyhemoglobin dissociation curve in blood with pH values of approximately 6.30. ( Leraand, S; Opdahl, H; Refsum, HE, 1997) |
| " In addition, all tyrphostins and genistein attenuated the liver injury/failure, the pancreatic injury, the hypoglycaemia and the lactic acidosis caused by LPS." | 3.69 | Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: a possible role for protein tyrosine kinase. ( Ruetten, H; Thiemermann, C, 1997) |
| " We hypothesized that the lactic acidosis which identifies those at the greatest risk of death often represents an oxygen debt incurred as a result of inadequate tissue perfusion." | 3.69 | Lactic acidosis and oxygen debt in African children with severe anaemia. ( English, M; Marsh, K; Mithwani, S; Muambi, B, 1997) |
| "Lactic acidosis decreases left ventricular contractility, but whether bicarbonate increases left ventricular contractility during lactic acidosis in vivo is controversial." | 3.68 | Bicarbonate does not increase left ventricular contractility during L-lactic acidemia in pigs. ( Cooper, DJ; Herbertson, MJ; Walley, KR; Werner, HA, 1993) |
| "During an incremental exercise test, three consequences of the onset of anaerobic metabolism can be observed: rise in blood lactate (lactate threshold, LT); fall in standard bicarbonate (lactic acidosis threshold, LAT); nonlinear increase in CO2 output (V-slope gas exchange threshold, GET)." | 3.68 | Comparison of gas exchange, lactate, and lactic acidosis thresholds in patients with chronic obstructive pulmonary disease. ( Appendini, L; Carone, M; Casaburi, R; Donner, CF; Patessio, A; Wasserman, K, 1993) |
| "Congenital lactic acidosis form a large group of disorders that are commonly associated with profound neurological dysfunction." | 3.68 | Proton magnetic resonance spectroscopy studies in lactic acidosis and mitochondrial disorders. ( Connelly, A; Cross, JH; Gadian, DG; Leonard, JV, 1993) |
| " Twenty-five patients with chronic heart failure performed cycle ergometry for 6 min at 25 W and at a work rate midway (50 percent delta) between their lactic acidosis threshold (LAT) and peak VO2." | 3.68 | O2 uptake kinetics in response to exercise. A measure of tissue anaerobiosis in heart failure. ( Barstow, TJ; Ben-Dov, I; Mizumoto, G; Sietsema, KE; Sullivan, CS; Wasserman, K; Zhang, YY, 1993) |
| "Plasma ionized calcium [Ca++] concentrations are decreased in patients having lactic acidosis." | 3.68 | Plasma ionized calcium and blood lactate concentrations are inversely associated in human lactic acidosis. ( Cooper, DJ; Dodek, PM; Rosenberg, F; Russell, JA; Walley, KR, 1992) |
| " Chronic lactic acidosis (lactate, 10 +/- 1 mmol/L) persisted for more than 5 wk." | 3.68 | Chronic lactic acidosis in a patient with acquired immunodeficiency syndrome and mitochondrial myopathy: biochemical studies. ( Cheema-Dhadli, S; Gopinath, R; Halperin, M; Hutcheon, M, 1992) |
| " Within 5-15 min after the onset of reperfusion, the Lac/NAA peak ratio increased further in all rats; however, only in extremely hyperglycemic rats (serum glucose greater than 960 mg/dl) did the lactic acidosis progress rather than recover later during reperfusion." | 3.68 | Effects of hyperglycemia on the time course of changes in energy metabolism and pH during global cerebral ischemia and reperfusion in rats: correlation of 1H and 31P NMR spectroscopy with fatty acid and excitatory amino acid levels. ( Abiko, H; Faden, AI; James, TL; Weinstein, PR; Widmer, H, 1992) |
| " The lactic acidosis threshold and VO2 kinetics were examined." | 3.68 | Is the anaerobic threshold truly anaerobic? ( Koike, A; Wasserman, K, 1992) |
| " Thus we investigated the effect of lactic acidosis and two proposed treatments on myocardial energetics and intracellular pH in anesthetized living rats." | 3.68 | Lactic acidosis: effect of treatment on intracellular pH and energetics in living rat heart. ( Barrett, E; Gore, JC; Greene, R; Majumdar, S; Zahler, R, 1992) |
| " We propose low molar ratios of ketone bodies in plasma of neonates with congenital lactic acidosis as an indication of dysfunction of the tricarboxylic acid cycle." | 3.68 | Alpha-ketoglutarate dehydrogenase deficiency presenting as congenital lactic acidosis. ( Aupetit, J; Bonnefont, JP; Charpentier, C; Chretien, D; Munnich, A; Rabier, D; Robinson, B; Rustin, P; Saudubray, JM; Vassault, A, 1992) |
| "Two patients aged 37 and 44 years developed life-threatening lactic acidosis following abdominal surgery and a period of about 3 weeks of total parenteral nutrition." | 3.68 | [Thiamine deficiency as a cause of life threatening lactic acidosis in total parenteral nutrition]. ( Asskali, F; Behne, M; Kessler, P; Klein, G; Lorenz, M; Probst, S; Steuer, A, 1991) |
| "The risk of D-lactic acidosis after consumption of yogurt was investigated in seven healthy volunteers." | 3.68 | Postprandial plasma D-lactate concentrations after yogurt ingestion. ( Barth, CA; de Vrese, M, 1991) |
| " We hypothesized that the lactic acidosis associated with prolonged systemic hypoxemia might mediate the adaptation of the hypoxemic inhibition of FBM." | 3.68 | Vascular lactic acid infusions do not alter the incidence of fetal breathing movements or their inhibition by acute hypoxemia. ( Bissonnette, JM; Hohimer, AR, 1991) |
| "To determine whether the levels of oxygen consumption (VO2) required to relieve an existing oxygen debt are variable, increases in VO2 produced by increases in oxygen delivery (DO2) were evaluated longitudinally in septic patients with lactic acidosis and related to changes in lactate levels." | 3.68 | Lack of a relationship between induced changes in oxygen consumption and changes in lactate levels. ( Silverman, HJ, 1991) |
| " Despite this there is still controversy about the most appropriate therapy of lactic acidosis, and the relationship of commonly used acid base measurements to blood lactate levels." | 3.68 | Lactate and acid base changes in the critically ill. ( Grant, IS; Mackenzie, SJ; Nimmo, GR, 1991) |
| "We report a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes who experienced visual and auditory hallucinations." | 3.68 | Therapeutic effect of sodium dichloroacetate on visual and auditory hallucinations in a patient with MELAS. ( Hashimoto, T; Ito, M; Kuroda, Y; Naito, E; Saijo, T; Takeda, E, 1991) |
| " Patients with mitochondrial encephalopathy with lactic acidosis and stroke-like episodes demonstrated only minor changes in redox state and in the behavior of the mitochondrial respiratory chain." | 3.68 | The use of skin fibroblast cultures in the detection of respiratory chain defects in patients with lacticacidemia. ( Capaldi, R; Chow, W; Glerum, DM; Lightowlers, R; Petrova-Benedict, R; Robinson, BH, 1990) |
| "Phenformin-induced lactic acidosis has been thought to be rare in India due to a high carbohydrate intake, use of suboptimal doses of phenformin and a lesser prevalence of alcoholism, as compared to Western countries." | 3.68 | Biguanide-induced lactic acidosis. ( Chandalia, HB; Rangnath, M, 1990) |
| "Manipulation of carbohydrate intake was used to treat severe, recurrent D-lactic acidosis in a patient with short bowel syndrome." | 3.68 | Dietary management of D-lactic acidosis in short bowel syndrome. ( Booth, IW; George, RH; Handy, DJ; Mayne, AJ; Preece, MA, 1990) |
| "Two patients, both with short bowel syndrome, presented with severe D-lactic acidosis associated with subacute small bowel obstruction and bizarre neurological signs." | 3.68 | D-lactic acidosis in short bowel syndrome--an examination of possible mechanisms. ( Hudson, M; Mowat, NA; Pocknee, R, 1990) |
| "We sought to determine the longitudinal distribution of pulmonary vascular resistance (PVR) in acute lactic acidosis utilizing pulmonary artery and vein balloon occlusion techniques (Holloway et al." | 3.68 | Distribution of pulmonary vascular resistance during lactic acid infusion in dogs. ( Abrahams, C; Lewis, T; Melendres, J; Presberg, KW; Sznajder, JI; Wood, LD, 1990) |
| " We studied the effects of carbicarb in an animal preparation of hypoxic lactic acidosis (HLA)." | 3.67 | Improved hemodynamic function during hypoxia with Carbicarb, a new agent for the management of acidosis. ( Arieff, AI; Bersin, RM, 1988) |
| " In the investigation it was found: lactic acidosis; stroke like episodes and calcification in the basal ganglia on computerized axial tomography; ragged red fibers on muscle biopsy and decreased of cytochrome C oxidase in the muscle tissue." | 3.67 | [MELAS (mitochondrial encephalopathy, lactic acidosis and stroke-like episodes): report of a case]. ( Abdalla, H; Lohr, A; Werneck, LC, 1987) |
| "Lactic acidosis is seen frequently after severe anoxia and circulatory failure." | 3.67 | Effect of dichloroacetate in the treatment of anoxic lactic acidosis in dogs. ( Caputo, G; Delgado Paredes, C; Egler, J; Fleisher, G; Schaible, D; Sheikh, A; Swedlow, D, 1986) |
| "Critics of bicarbonate therapy for life-threatening lactic acidosis have argued that the treatment is not only ineffective but that it also worsens morbidity and mortality." | 3.67 | Bicarbonate therapy for organic acidosis: the case for its continued use. ( Cohen, JJ; Narins, RG, 1987) |
| "A mitochondrial defect was investigated in an infant with fatal congenital lactic acidosis (3-14 mM), high lactate-to-pyruvate ratio, hypotonia, and cardiomyopathy." | 3.67 | Deficiency of the reduced nicotinamide adenine dinucleotide dehydrogenase component of complex I of mitochondrial electron transport. Fatal infantile lactic acidosis and hypermetabolism with skeletal-cardiac myopathy and encephalopathy. ( Dahms, B; Hoppel, CL; Kerr, DS; Roessmann, U, 1987) |
| "The role of lactic acidosis of progressive brain hypoxia (PBH) as both a central chemoreceptor stimulant and a general respiratory depressant was assessed by preventing lactate formation both locally and globally with dichloroacetate (DCA)." | 3.67 | Role of brain lactic acidosis in hypoxic depression of respiration. ( Edelman, NH; Neubauer, JA; Simone, A, 1988) |
| " The responsiveness of these receptors to acetic, propionic, butyric and DL-lactic acids were assessed as well as their ability to be activated by rumen fluids obtained from sheep with induced ruminal lactic acidosis." | 3.67 | Ruminal lactic acidosis: forestomach epithelial receptor activation by undissociated volatile fatty acids and rumen fluids collected during loss of reticuloruminal motility. ( Crichlow, EC, 1988) |
| " strain LB17, was used to study the effects of the ionophores monensin and tetronasin on the changes in ruminal microbial ecology that occur during the onset of lactic acidosis." | 3.67 | Effects of the ionophores monensin and tetronasin on simulated development of ruminal lactic acidosis in vitro. ( Newbold, CJ; Wallace, RJ, 1988) |
| "The rat hippocampal slice preparation was used to study the combined effects of hypoxia and lactic acidosis on neuronal function." | 3.67 | Lactic acidosis and recovery of neuronal function following cerebral hypoxia in vitro. ( Dong, WQ; Reid, KH; Rigor, BM; Schurr, A; West, CA, 1988) |
| ") in rats produced tremors and convulsions with lactic acidosis which was accompanied by depletion of glycogen and activation of glycogen phosphorylase activity in triceps and diaphragm muscles, 2 h after its administration." | 3.67 | Convulsions as the etiology of lactic acidosis in acute diazinon toxicity in rats. ( Husain, K; Matin, MA; Mirza, MA, 1987) |
| "We have investigated the effect of dichloroacetate (DCA) on the urinary excretion of lactate and pyruvate in a patient with congenital lactic acidosis and in healthy human controls." | 3.67 | Renal effects of dichloroacetate in vivo. ( Kamoshita, S; Kodama, H; Kodama, M; Okabe, I; Orii, T; Yamaguchi, S, 1986) |
| " A diagnosis of idiopathic lactic acidosis was established when the arterial blood pH was found to be 6." | 3.64 | THE CLINICAL SIGNIFICANCE OF ELEVATED BLOOD LACTATE. ( PHILLIPSON, EA; SPROULE, BJ, 1965) |
| "Fenoldopam infusion was well tolerated in all patients." | 2.79 | Beneficial effect of fenoldopam mesylate in preventing peak blood lactate level during cardiopulmonary bypass for paediatric cardiac surgery. ( Calevo, MG; Carleo, AM; Lerzo, F; Montobbio, G; Petrucci, L; Ressia, L, 2014) |
| ""Lactic acidosis" is thus an inappropriate term as it indicates causality and in this review, we suggest that in the future, the term "hyperlactataemia-associated metabolic acidosis" should be used instead." | 2.72 | [Hyperlactataemia]. ( Andreasen, AS; Berg, RM; Iepsen, UW; Jeppesen, TE; Mohammad, M; Plovsing, RR, 2021) |
| " Similarly, no adverse changes occurred in systemic or pulmonary arterial pressures or in cardiac ejection fraction." | 2.67 | Safety of low-dose intraoperative bicarbonate therapy: a prospective, double-blind, randomized study. The Study of Perioperative Ischemia (SPI) Research Group. ( Arieff, AI; Leung, JM; Mangano, DT; Mark, NH, 1993) |
| "Cardiogenic shock is difficult to diagnose due to diverse presentations, overlap with other shock states (i." | 2.66 | Identifying cardiogenic shock in the emergency department. ( Daly, M; Koyfman, A; Lentz, S; Long, B, 2020) |
| "Early-onset hyperlactatemia is that which develops in the operating room or very early following intensive care unit (ICU) admission." | 2.55 | Hyperlactatemia and Cardiac Surgery. ( Minton, J; Sidebotham, DA, 2017) |
| "Metformin is known to cause potentially fatal metabolic acidosis with an increased lactate level in both overdose and therapeutic use." | 2.45 | Acute metformin overdose: examining serum pH, lactate level, and metformin concentrations in survivors versus nonsurvivors: a systematic review of the literature. ( Abramson, J; Dell'Aglio, DM; Kazzi, Z; Morgan, BW; Perino, LJ; Schwartz, MD, 2009) |
| "During prolonged anoxia at low temperature, freshwater turtles develop high plasma concentrations of both lactate and calcium." | 2.42 | Surviving extreme lactic acidosis: the role of calcium lactate formation in the anoxic turtle. ( Jackson, DC, 2004) |
| " Because there is little in the published scientific medical literature regarding the effects of long-term administration of probiotics to infants, potential problems must be considered; one such issue is that of administration of D(-)-lactate-producing probiotics." | 2.42 | D(-)-lactic acid-producing probiotics, D(-)-lactic acidosis and infants. ( Mack, DR, 2004) |
| "The exercise lactic acidosis has been observed to occur after the minimal capillary PO2 is reached." | 2.39 | Coupling of external to cellular respiration during exercise: the wisdom of the body revisited. ( Wasserman, K, 1994) |
| "Sepsis is frequently characterized by a number of metabolic abnormalities: increased plasma lactate concentration, metabolic acidosis, increased glycolysis, and an abnormal "delivery-dependent" oxygen consumption." | 2.38 | Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis. ( Hotchkiss, RS; Karl, IE, 1992) |
| " The previously unstudied dose-response also was evaluated in our study." | 2.38 | Effects of various doses of sodium dichloroacetate on hyperlactatemia in fed ischemic rats. ( Dimlich, RV; Kaplan, J; Timerding, BL; Van Ligten, PF, 1989) |
| "Lactic acid (LA) is a byproduct of glycolysis resulting from intense exercise or a metabolic defect in aerobic processes." | 1.56 | Novel metabolic system for lactic acid via LRPGC1/ERRγ signaling pathway. ( Matsuda, KI; Tanaka, M; Tanida, T, 2020) |
| "Is it really septic shock? Our aim was to determine differences in outcome between patients diagnosed as having septic shock but exhibiting normal vs elevated lactate levels during evolution." | 1.37 | Persistent sepsis-induced hypotension without hyperlactatemia: is it really septic shock? ( Angulo, D; Aranguiz, I; Bruhn, A; Bujes, A; Castro, R; de la Hoz, C; Hernandez, G; Larrondo, J; Romero, C, 2011) |
| "Tachycardia is an important early sign of shock in trauma." | 1.37 | Discrepancy between heart rate and makers of hypoperfusion is a predictor of mortality in trauma patients. ( Ishikawa, K; Matsuoka, T; Mizushima, Y; Ueno, M; Watanabe, H, 2011) |
| "Her lactic acid concentration was 16." | 1.36 | A case of human poisoning with a flufenoxuron-containing insecticide. ( Cho, SJ; Han, SK; Jeong, J; Kim, J; Ryu, J; Yeom, S, 2010) |
| "Patients with chronic obstructive pulmonary disease (COPD) may suffer dyspnea when performing unsupported arm exercises (UAE)." | 1.36 | Lactic acid levels in patients with chronic obstructive pulmonary disease accomplishing unsupported arm exercises. ( Castro, AA; de Souza, GF; Jardim, JR; Silva, CR; Velloso, M, 2010) |
| "PDHc deficiency was demonstrated in muscle and fibroblasts without detectable PDHA1 mutations." | 1.36 | Dihydrolipoamide dehydrogenase (DLD) deficiency in a Spanish patient with myopathic presentation due to a new mutation in the interface domain. ( Briones, P; Font, A; Pineda, M; Quintana, E; Ribes, A; Tort, F; Vilaseca, MA, 2010) |
| "He had a history of psychoses and substance abuse." | 1.36 | Falsely elevated lactate in severe ethylene glycol intoxication. ( Rood, PP; Russcher, H; Sandberg, Y; van Daele, PL; Weige, JD; Zwaans, JJ, 2010) |
| "Ethylene glycol poisoning is a medical emergency." | 1.35 | False elevation of blood lactate reveals ethylene glycol poisoning. ( Bénéteau-Burnat, B; Maury, E; Offenstadt, G; Pernet, P; Vaubourdolle, M, 2009) |
| "Shock was more frequently present in the low [BE] group (46% versus 24%, P = 0." | 1.35 | Severe hyperlactatemia with normal base excess: a quantitative analysis using conventional and Stewart approaches. ( Dubin, A; Kutscherauer, DO; Masevicius, FD; Pein, MC; Tuhay, G, 2008) |
| "The conditions included seizures, inflammatory changes, and proven metabolic disorders." | 1.33 | The significance of elevated CSF lactate. ( Chow, SL; Clayton, PT; Cleary, MA; Leonard, JV; Rooney, ZJ, 2005) |
| "Striatal lactic acidosis was performed by direct addition of lactic acid in the incubation medium to obtain a pH as close as possible to that observed in ischemia." | 1.32 | Lactic acidosis progressively impairs dopamine uptake in rat striatal synaptosomes by a mechanism partially independent of the Na+/K+-ATPase dysfunction. ( Barc-Pain, S; Barrier, L; Bestel, E; Fauconneau, B; Page, G; Stadelmann-Ingrand, S, 2004) |
| "Lactic acid levels were 1." | 1.31 | Oxygen consumption, carbon dioxide production and lactic acid during normothermic cardiopulmonary bypass. ( Engoren, M; Evans, M, 2000) |
| "Osteopenia has been associated with antiretroviral therapy, particularly with protease inhibitors." | 1.31 | Osteopenia in HIV-infected men: association with asymptomatic lactic acidemia and lower weight pre-antiretroviral therapy. ( Carr, A; Cooper, DA; Eisman, JA; Miller, J, 2001) |
| "Recurrent episodes of confusion are most commonly due to transient brain dysfunction related to vascular, epileptic or metabolic abnormalities." | 1.31 | [Recurrent encephalopathy after small bowel resection. Implication of D-lactate]. ( Burkhard, PR; Hadengue, A; Lalive, PH; Mensi, N, 2001) |
| "Ten critically ill patients with acute renal failure and stable blood lactate concentrations." | 1.30 | Effect of continuous venovenous hemofiltration with dialysis on lactate clearance in critically ill patients. ( Ciebiera, JP; Grimaud, D; Ichai, C; Jambou, P; Labib, Y; Levraut, J, 1997) |
| "Both steroids and hemorrhage may affect the hepatic energy metabolism." | 1.30 | [Effects of steroids on hepatic ATP and L/P ratio in rats subjected to acute hemorrhage]. ( Ikeya, K; Kashimoto, S; Kumazawa, T; Kume, M, 1997) |
| "The majority of patients with PDHC deficiency have abnormalities in the major catalytic and regulatory subunit, E1 alpha, which is encoded on the X chromosome." | 1.29 | Cerebral dysgenesis and lactic acidemia: an MRI/MRS phenotype associated with pyruvate dehydrogenase deficiency. ( Arnold, DL; Brown, GK; Brown, RM; Legris, M; Matthews, PM; Otero, LJ; Scriver, CR; Shevell, MI, 1994) |
| "Before cardiac arrest, the blood plasma glucose concentration in seven newborn (113 d postconception; normal gestation, 115 d) and seven 1-mo-old (144 d postconception) piglets was adjusted to a specific value (range, 1 to 64 mM), and then inspired ventilation gases were changed to 10:50:40 CO2:O2:N2 for 20 min." | 1.29 | The effect of hypercarbia on age-related changes in cerebral glucose transport and glucose-modulated agonal glycolytic rates. ( Corbett, RJ; Garcia, D; Laptook, AR; Sterett, R; Tollefsbol, G, 1993) |
| "During CO2 acidosis, anoxia had no effect on apparent nonbicarbonate buffer value (d[HCO3-]/dpHi = 71 and 89 mM/pH in normoxia and anoxia, respectively) or on pHi regulation (dpHi/dpHe = 0." | 1.28 | 31P-NMR study of normoxic and anoxic perfused turtle heart during graded CO2 and lactic acidosis. ( Arendt, EA; Inman, KC; Jackson, DC; Lawler, RG; Panol, G; Wasser, JS, 1991) |
| "Lactic acid has been shown to affect numerous biologic processes." | 1.28 | Lactic acidosis increases tumor necrosis factor secretion and transcription in vitro. ( Buresh, C; Jensen, JC; Norton, JA, 1990) |
| "D-Lactate-associated encephalopathy is a rare clinical syndrome characterized by dizziness, ataxia, confusion, headaches, memory loss, lethargy, and aggressiveness which may progress to frank but reversible coma." | 1.28 | D-lactate-associated encephalopathy after massive small-bowel resection. ( Carr, WC; Harig, JM; Kraft, SC; Scully, TB, 1989) |
| " Because higher doses of DCA may be more effective, the main objective of our study was to examine the dose-response of brain tissue lactate to DCA." | 1.28 | Effects of sodium dichloroacetate dose. Brain metabolites associated with cerebral ischemia. ( Cammenga, R; Dimlich, RV; Kaplan, J; Timerding, BL; Van Ligten, PF, 1989) |
| "The carnitine concentration was diminished in blood and muscle tissue." | 1.27 | Mitochondrial myopathy with lactic acidaemia, Fanconi-De Toni-Debré syndrome and a disturbed succinate: cytochrome c oxidoreductase activity. ( Guggenbichler, JP; Ruitenbeek, W; Sengers, RC; Sperl, W; Stadhouders, AM; Trijbels, JM, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (5.71) | 18.7374 |
| 1990's | 134 (21.24) | 18.2507 |
| 2000's | 199 (31.54) | 29.6817 |
| 2010's | 207 (32.81) | 24.3611 |
| 2020's | 55 (8.72) | 2.80 |
| Authors | Studies |
|---|---|
| Nguyen, KTL | 1 |
| Chiou, JY | 1 |
| Liu, YC | 1 |
| Cheng, FJ | 1 |
| Shen, YC | 1 |
| Chen, CJ | 1 |
| Tang, CH | 1 |
| Huang, WC | 1 |
| Chen, CH | 1 |
| Tu, CY | 1 |
| Berg, RM | 1 |
| Jeppesen, TE | 1 |
| Mohammad, M | 1 |
| Andreasen, AS | 1 |
| Iepsen, UW | 1 |
| Plovsing, RR | 1 |
| Van De Ginste, L | 1 |
| Vanommeslaeghe, F | 1 |
| Hoste, EAJ | 1 |
| Kruse, JM | 1 |
| Van Biesen, W | 1 |
| Verbeke, F | 1 |
| Adam, C | 1 |
| Paolini, L | 1 |
| Gueguen, N | 1 |
| Mabilleau, G | 1 |
| Preisser, L | 1 |
| Blanchard, S | 1 |
| Pignon, P | 1 |
| Manero, F | 1 |
| Le Mao, M | 1 |
| Morel, A | 1 |
| Reynier, P | 2 |
| Beauvillain, C | 1 |
| Delneste, Y | 1 |
| Procaccio, V | 1 |
| Jeannin, P | 1 |
| Wang, C | 2 |
| Lv, Z | 1 |
| Zhang, Y | 1 |
| de Landsheere, F | 1 |
| Saint-Marcoux, F | 1 |
| Haufroid, V | 1 |
| Dulaurent, S | 1 |
| Dewulf, JP | 1 |
| Boland, L | 1 |
| Laterre, PF | 1 |
| Hantson, P | 3 |
| Theurey, P | 1 |
| Vial, G | 1 |
| Fontaine, E | 1 |
| Monternier, PA | 1 |
| Fouqueray, P | 1 |
| Bolze, S | 1 |
| Moller, DE | 1 |
| Hallakou-Bozec, S | 1 |
| Heneberg, P | 1 |
| Iacovino, LG | 1 |
| Rossi, M | 1 |
| Di Stefano, G | 1 |
| Rossi, V | 1 |
| Binda, C | 1 |
| Brigotti, M | 1 |
| Tomaselli, F | 1 |
| Pasti, AP | 1 |
| Dal Piaz, F | 1 |
| Cerini, S | 1 |
| Hochkoeppler, A | 1 |
| Podušel, V | 1 |
| Morgošová, S | 1 |
| Majdák, P | 1 |
| Sadloňová, J | 1 |
| Jentzer, JC | 1 |
| Schrage, B | 1 |
| Patel, PC | 1 |
| Kashani, KB | 1 |
| Barsness, GW | 1 |
| Holmes, DR | 1 |
| Blankenberg, S | 1 |
| Kirchhof, P | 1 |
| Westermann, D | 1 |
| Schiavoni, L | 1 |
| Mattei, A | 1 |
| Pascarella, G | 1 |
| Strumia, A | 1 |
| Nenna, A | 1 |
| Chello, M | 1 |
| Agrò, FE | 1 |
| Sener, K | 1 |
| Arslan, B | 1 |
| Ozselcuk, S | 1 |
| Guven, R | 1 |
| Zhan, YF | 1 |
| Shi, Q | 1 |
| Pan, YC | 1 |
| Zheng, BS | 1 |
| Ge, YP | 1 |
| Luo, TG | 1 |
| Xiao, ZH | 1 |
| Jiang, W | 1 |
| Asai, T | 1 |
| Kakita, H | 1 |
| Nakamura, N | 1 |
| Asai, S | 1 |
| Mori, M | 1 |
| Takeshita, S | 1 |
| Ueda, H | 1 |
| Mizuno, Y | 1 |
| Tomita, A | 1 |
| Aoyama, M | 1 |
| Yamada, Y | 1 |
| Rahman, F | 1 |
| Tuba, S | 1 |
| Martín-Rodríguez, F | 1 |
| Ortega, GJ | 1 |
| Castro Villamor, MA | 1 |
| Del Pozo Vegas, C | 1 |
| Delgado Benito, JF | 1 |
| Martín-Conty, JL | 1 |
| Sanz-García, A | 1 |
| López-Izquierdo, R | 1 |
| Xia, Y | 1 |
| Zhu, X | 1 |
| Wu, C | 1 |
| Sharma, K | 1 |
| Keri, VC | 1 |
| Kumar, TP | 1 |
| Sethi, P | 1 |
| Dass, J | 1 |
| Mishra, RK | 1 |
| Andreucci, E | 1 |
| Fioretto, BS | 1 |
| Rosa, I | 1 |
| Matucci-Cerinic, M | 1 |
| Biagioni, A | 1 |
| Romano, E | 1 |
| Calorini, L | 1 |
| Manetti, M | 1 |
| Hussain, M | 1 |
| Zaki, KE | 1 |
| Asef, MA | 1 |
| Song, H | 1 |
| Treger, RM | 1 |
| Hughes, BW | 1 |
| Gray, LA | 1 |
| Bradberry, SM | 1 |
| Sandilands, EA | 1 |
| Thanacoody, RH | 1 |
| Coulson, JM | 1 |
| Lefèvre, CR | 1 |
| Sacaze, E | 1 |
| Damaj, L | 1 |
| Rollier, P | 1 |
| Lenski, M | 1 |
| Le Stradic, C | 1 |
| Bendavid, C | 1 |
| Dieu, X | 1 |
| Prunier, D | 1 |
| Moreau, C | 1 |
| Homedan, C | 1 |
| Rivera, D | 1 |
| Onisko, N | 1 |
| Cao, JD | 1 |
| Koyfman, A | 2 |
| Long, B | 2 |
| Gkiourtzis, N | 1 |
| Tramma, D | 1 |
| Papadopoulou-Legbelou, K | 1 |
| Moutafi, M | 1 |
| Evangeliou, A | 1 |
| Cao, Y | 1 |
| Liu, MC | 1 |
| Hanlon, EL | 1 |
| Chen, Y | 1 |
| Afzal, MZ | 1 |
| Hayes, CA | 1 |
| Hill, JM | 1 |
| Daverio, Z | 1 |
| Kolkman, M | 1 |
| Perrier, J | 1 |
| Brunet, L | 1 |
| Bendridi, N | 1 |
| Sanglar, C | 1 |
| Berger, MA | 1 |
| Panthu, B | 1 |
| Rautureau, GJP | 1 |
| Yusim, D | 1 |
| Tiru, B | 1 |
| Abdullin, M | 1 |
| Landry, DL | 1 |
| Hodgins, S | 1 |
| Braden, GL | 1 |
| Jin, S | 1 |
| Chen, X | 1 |
| Yang, J | 1 |
| Ding, J | 1 |
| Moen, M | 1 |
| Hamilton-Dutoit, S | 1 |
| Steiniche, T | 1 |
| Gude, MF | 1 |
| Tanemoto, M | 2 |
| Yamada, S | 1 |
| Kimura, T | 1 |
| Yokoyama, T | 1 |
| Okazaki, Y | 1 |
| Wardi, G | 1 |
| Brice, J | 1 |
| Correia, M | 1 |
| Liu, D | 1 |
| Self, M | 1 |
| Tainter, C | 1 |
| Li, W | 1 |
| Zhang, L | 2 |
| Huang, X | 1 |
| Feng, D | 1 |
| Zou, X | 1 |
| Zhou, Y | 1 |
| Nestor, C | 1 |
| Nasim, S | 1 |
| Coyle, N | 1 |
| Canavan, C | 1 |
| Merrells, RJ | 1 |
| Cripps, AJ | 1 |
| Chivers, PT | 1 |
| Fournier, PA | 1 |
| Kamel, KS | 3 |
| Oh, MS | 3 |
| Halperin, ML | 3 |
| Weemaes, M | 1 |
| Hiele, M | 1 |
| Vermeersch, P | 1 |
| Blumenberg, A | 2 |
| Benabbas, R | 2 |
| Sinert, R | 2 |
| Jeng, A | 2 |
| Wiener, SW | 2 |
| Smith, FC | 1 |
| Stocker, SL | 1 |
| Danta, M | 1 |
| Carland, JE | 1 |
| Kumar, SS | 2 |
| Liu, Z | 2 |
| Greenfield, JR | 3 |
| Braithwaite, HE | 1 |
| Cheng, TS | 1 |
| Graham, GG | 3 |
| Williams, KM | 3 |
| Day, RO | 3 |
| Barnes, EME | 1 |
| Xu, Y | 1 |
| Benito, A | 1 |
| Herendi, L | 1 |
| Siskos, AP | 1 |
| Aboagye, EO | 1 |
| Nijhuis, A | 1 |
| Keun, HC | 1 |
| Wang, JJ | 1 |
| Hoffman, RS | 3 |
| Worrell, SG | 1 |
| Haug, K | 1 |
| Dubovoy, A | 1 |
| Lin, J | 1 |
| Engoren, M | 2 |
| Ogata, T | 1 |
| Makino, H | 1 |
| Ishizuka, N | 1 |
| Iwamoto, E | 1 |
| Masaki, T | 1 |
| Kizaki, K | 1 |
| Kim, YH | 1 |
| Sato, S | 1 |
| Stephens, EH | 1 |
| Epting, CL | 1 |
| Backer, CL | 1 |
| Wald, EL | 1 |
| Thomson, G | 1 |
| Simon, A | 1 |
| Cazaubon, Y | 1 |
| Schneider, N | 1 |
| Oudart, JB | 1 |
| Lefrère, B | 1 |
| Ecochard-Dugelay, E | 1 |
| Mosca, A | 1 |
| Benoist, JF | 1 |
| Hugot, JP | 1 |
| Imbard, A | 1 |
| Tanida, T | 1 |
| Matsuda, KI | 1 |
| Tanaka, M | 2 |
| Goonoo, MS | 1 |
| Morris, R | 1 |
| Raithatha, A | 1 |
| Creagh, F | 1 |
| Baumann, L | 1 |
| Studhalter, M | 1 |
| Elshafei, MN | 1 |
| Alamin, M | 1 |
| Mohamed, MFH | 1 |
| Daly, M | 1 |
| Lentz, S | 1 |
| Prouhèze, A | 1 |
| Girault, A | 1 |
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| Lepercq, J | 1 |
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| Mangues-Bafalluy, MA | 1 |
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| Simard, C | 1 |
| Schwartz, BC | 1 |
| Thinnes, A | 1 |
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| Lehto, A | 1 |
| Wirth, F | 1 |
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| Ma, X | 1 |
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| Bosco, P | 1 |
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| de Sain-van der Velden, MGM | 1 |
| Knoers, NV | 1 |
| Bakkers, J | 1 |
| Verhoeven-Duif, NM | 1 |
| van Haaften, G | 1 |
| Jans, JJ | 1 |
| Prabhu, RA | 1 |
| Mareddy, AS | 1 |
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| Rangaswamy, D | 1 |
| Guddattu, V | 1 |
| Taub, ES | 1 |
| Manini, AF | 1 |
| Patel, JJ | 1 |
| Bergl, P | 1 |
| Lindberg, D | 1 |
| Ho, AMC | 1 |
| Peyton, L | 1 |
| Choi, DS | 1 |
| Zhang, QC | 2 |
| Hastings, C | 1 |
| Johnson, K | 1 |
| Slaven, E | 1 |
| Abdessadek, M | 1 |
| Khabbal, Y | 1 |
| Magoul, R | 1 |
| Marmouzi, I | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study of Metformin Overdose in Adult Patients Treated at the University Hospital of Nancy: Single-center Descriptive Retrospective Observational Study[NCT04762966] | 50 participants (Anticipated) | Observational | 2021-03-01 | Recruiting | |||
| Pilot Feasibility Study of Fecal Microbiota Transplant for the Treatment of Small Intestinal Bacterial Overgrowth[NCT05967871] | Phase 1 | 20 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
| Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)[NCT05120284] | Phase 2 | 40 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
| Phase 3 Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency:[NCT02616484] | Phase 3 | 34 participants (Actual) | Interventional | 2020-07-14 | Active, not recruiting | ||
| Effect of the Administration of Melatonin and Metformin on Glycemic Control, Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes: Pilot Study[NCT03848533] | Phase 2 | 42 participants (Anticipated) | Interventional | 2019-08-22 | Recruiting | ||
| Mitochondrial Encephalomyopathies and Mental Retardation: Investigations of Clinical Syndromes Associated With MtDNA Point Mutations[NCT01532791] | 300 participants (Anticipated) | Observational | 2004-07-31 | Recruiting | |||
| Mean Arterial Pressure (MAP) Trial: Study Protocol for a Multicenter, Randomized, Controlled Trial to Compare Three Different Strategies of Mean Arterial Pressure Management During Cardiopulmonary By-pass[NCT05740397] | 900 participants (Anticipated) | Interventional | 2021-05-03 | Recruiting | |||
| Determination of Ka of Isolated Plasma and Whole Blood of Critically Ill Patients With Sepsis, Non-septic Patients and Healthy Volunteers: an International, In-vitro Acid-base Study.[NCT03966664] | 90 participants (Anticipated) | Observational | 2019-06-03 | Recruiting | |||
| Perioperative Continuation of Metformin Therapy in Patients With Typ 2 Diabetes Mellitus Undergoing Non-cardiac Surgery[NCT04284722] | Phase 4 | 400 participants (Anticipated) | Interventional | 2020-02-29 | Not yet recruiting | ||
| A Prospective, Randomized Open-Label Phase II Study of the Safety and Tolerability of Metformin in Combination With Standard Antimicrobial Treatment of Pulmonary Tuberculosis in People With TB and Co-infected With HIV[NCT04930744] | Phase 2 | 112 participants (Anticipated) | Interventional | 2021-08-03 | Recruiting | ||
| Metformin Continuation Versus Interruption Following Coronary Angiography: a Pilot Randomized Controlled Trial[NCT03980990] | Phase 4 | 500 participants (Anticipated) | Interventional | 2019-06-17 | Recruiting | ||
| A Randomized Trial of Metformin as Adjunct Therapy for Overweight Adolescents With Type 1 Diabetes[NCT01881828] | Phase 3 | 164 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| Capillary Refill Time Response to a Rapid Fluid Challenge in Septic Shock Patients: Pathophysiological Determinants, and Relation to Changes in Systemic, Regional and Microcirculatory Blood Flow[NCT04693923] | 42 participants (Anticipated) | Interventional | 2021-02-01 | Not yet recruiting | |||
| Early Goal Directed Therapy Using a Physiological Holistic View. A Multicenter Study in Latin America: The ANDROMEDA-SHOCK Study[NCT03078712] | 424 participants (Actual) | Interventional | 2017-03-01 | Completed | |||
| Association of Postoperative Lactate Levels With Postoperative Atrial Fibrillation in Patients Undergoing Isolated Coronary Artery Bypass Graft Surgery[NCT05448521] | 250 participants (Anticipated) | Observational | 2022-08-15 | Recruiting | |||
| Prognostic Value of Peak Lactate During Cardiopulmonary Bypass in Adult Cardiac Surgeries: a Cohort Study[NCT03934892] | 97 participants (Actual) | Observational | 2015-01-01 | Completed | |||
| "Influence of High Vitamin C Dose on Lactate During Extracorporeal Circulation for Heart Surgery and During the 24 Hours Thereafter. (Double Blind Prospective Randomised Study)"[NCT04046861] | 200 participants (Anticipated) | Interventional | 2023-02-01 | Not yet recruiting | |||
| Carnosine for Peripheral Arterial Disease Patients (Car-PAD)[NCT05371145] | Phase 1/Phase 2 | 20 participants (Anticipated) | Interventional | 2023-03-01 | Recruiting | ||
| Effect of Blood Storage Age on the Resolution of Lactic Acidosis in Children With Severe Malarial Anemia at Mulago Hospital[NCT01580111] | 74 participants (Actual) | Interventional | 2010-12-31 | Completed | |||
| Strong Ion Gap as Prognostic Indicator for Adult Patients Admitted With Shock to the Intensive Care Units[NCT02652364] | 112 participants (Actual) | Observational | 2015-10-31 | Completed | |||
| Use of Nitroglycerine to Improve Signs of Poor Peripheral Perfusion in Patients With Traumatic Hemorrhagic Shock[NCT03235921] | Phase 2 | 100 participants (Anticipated) | Interventional | 2016-03-31 | Recruiting | ||
| The Effects of Swedish Massage and Manual Lymph Drainage After Muscle Fatigue in Healthy Young Men[NCT06112899] | 12 participants (Anticipated) | Interventional | 2023-10-26 | Not yet recruiting | |||
| [NCT01824771] | 15 participants (Actual) | Observational [Patient Registry] | 2013-03-03 | Completed | |||
| Almitrine and Severe COVID-19 Patients in ICU [Almitrine et Patients COVID-19 en Reanimation (French)][NCT04380727] | 17 participants (Actual) | Observational [Patient Registry] | 2020-03-20 | Completed | |||
| Early Lactate-Directed Therapy on the ICU: A Randomized Controlled Trial[NCT00270673] | Phase 3 | 350 participants (Anticipated) | Interventional | 2006-02-28 | Completed | ||
| Emergency Department (ED) Flow-directed Fluid Optimization Resuscitation Trial (EFFORT)[NCT01128413] | 22 participants (Actual) | Interventional | 2010-07-31 | Terminated (stopped due to lack of resources) | |||
| Assessing the Relationship Between Fatigue and Mitochondrial Toxicity in Patients With HIV/AIDS[NCT00106795] | 82 participants (Actual) | Observational | 2005-03-22 | Completed | |||
| Pharmacotoxicology of Trichloroethylene Metabolites: Short-term Effect of DCA on in Vivo Tyrosine Catabolism and MAAI Expression[NCT00865514] | 2 participants (Actual) | Interventional | 2011-08-31 | Terminated (stopped due to Difficulty in obtaining the solution from the compounding pharmacies caused a two year delay in start-up; the funding ended prior to study completion.) | |||
| Comparing Exercise Capacity in Patients With COPD Using High Flow Nasal Cannula Oxygen vs The Venturi Mask[NCT02858960] | 28 participants (Actual) | Interventional | 2016-04-30 | Completed | |||
| Exercise Capacity Testing in COPD Patients With High Flow Nasal Cannula[NCT02860273] | 28 participants (Actual) | Interventional | 2016-04-30 | Completed | |||
| Phase 3 Trial of Coenzyme Q10 in Mitochondrial Disease[NCT00432744] | Phase 3 | 24 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in percent body fat (NCT01881828)
Timeframe: 0-26 weeks
| Intervention | percentage of change (Mean) |
|---|---|
| Metformin | -0 |
| Oral Placebo | 1 |
(NCT01881828)
Timeframe: 0-26 weeks
| Intervention | percentile (Mean) |
|---|---|
| Metformin | -1 |
| Oral Placebo | 1 |
(NCT01881828)
Timeframe: 0-26 weeks
| Intervention | insulin per kg (Mean) |
|---|---|
| Metformin | -0.1 |
| Oral Placebo | -0.0 |
(NCT01881828)
Timeframe: 0-26 weeks
| Intervention | centimeters (Mean) |
|---|---|
| Metformin | -0 |
| Oral Placebo | 1 |
(NCT01881828)
Timeframe: 0-26 weeks
| Intervention | mm Hg (Mean) | |
|---|---|---|
| Change in Systolic | Change in Diastolic | |
| Metformin | 0 | 0 |
| Oral Placebo | -0 | 0 |
Hemoglobin A1c is a measure of glycemic control over approximately the past 3 months (NCT01881828)
Timeframe: 0-26 weeks
| Intervention | percentage (Mean) | |
|---|---|---|
| HbA1c | Change from Baseline to 26 Weeks | |
| Metformin | 9.0 | 0.2 |
| Oral Placebo | 8.9 | 0.2 |
Hemoglobin A1c is a measure of glycemic control over approximately the past 3 months (NCT01881828)
Timeframe: 0-26 weeks
| Intervention | percentage of participants (Number) | ||
|---|---|---|---|
| HbA1c Decrease ≥0.5% | HbA1c Increase ≥0.5% | HbA1c <7.5% | |
| Metformin | 19 | 44 | 3 |
| Oral Placebo | 18 | 35 | 4 |
(NCT01881828)
Timeframe: 0-26 weeks
| Intervention | mg/dL (Mean) | ||||
|---|---|---|---|---|---|
| Change in LDL | Change in VLDL | Change in HDL | Change in Triglycerides | Change in Total Cholesterol | |
| Metformin | -6 | -0 | -0 | 4 | -5 |
| Oral Placebo | 2 | 1 | -1 | 6 | 3 |
The median lactate clearance from time zero to within 6 hours of the ED stay. (NCT01128413)
Timeframe: The median lactate clearance within 6 hours of the ED stay.
| Intervention | percent lactate clearance (Median) |
|---|---|
| Fluid Optimization (FO) | 54 |
| Routine Care (RC) | 56 |
The McMaster Gross Motor Function is a validated scale ranging from 0 to 100 (the higher the better). Since there was the possibility of a subject becoming totally disabled our FDA peer reviewed design called for its use as follows: If the subject completed both periods, the score was calculated as the difference in scores between the end of Period 2 (at 12 months) minus that at the end of Period 1 (6 months). If a subject became totally disabled, this difference was considered as plus infinity if it occurred in period 1 (Penalizes period 1), and minus infinity if it occurred in Period 2 (Penalizes period 2). The two treatments were compared via the Wilcoxon test, and the effect size was estimated using Kendall's Tau-B. This is interpreted in a similar manner to correlation with positive values favoring COQenzyme10 and negative values favoring placebo. One of the links in this report is to the the GMFM scale and how it is scored. A link to the instrument is included. (NCT00432744)
Timeframe: Taken at 6 and 12 Months
| Intervention | units on a scale (Median) |
|---|---|
| Placebo First | -0.002 |
| CoenzymeQ10 Frist | -0.12 |
This is a multivariate analysis of the first two outcomes: Period 2 minus Period 1 GMFM88 and Peds Quality of Life, analyzed as follows: First, to be in the analysis, subjects must contribute at least one of these endpoints. Second, if the subject became totally disabled during period 1, the difference was defined as + infinity, (highest possible evidence favoring period 2), and if the subject became totally disabled in period 2, the subject was scored as - infinity (highest possible evidence favoring period 1). Period 2 minus period 1 differences were ranked form low to high with missing values scores at the mid-rank. The Hotelling T-square was computed on these ranks and the P-value was obtained from 100,000 rerandomizations as the fraction of rerandomizations with T-sq at least as large as that observed. (NCT00432744)
Timeframe: end of 12 month minus end of 6 month difference.
| Intervention | participants (Number) |
|---|---|
| Placebo First | 7 |
| CoenzymeQ10 Frist | 8 |
"The Pediatric Quality of Life Scale is a validated scale ranging from 0 to 100 (the higher the better). Since there was the possibility of a subject becoming totally disabled our FDA peer reviewed design called for its use as follows: If the subject completed both periods, the score was calculated as the difference in scores between the end of Period 2 (at 12 months) minus that at the end of Period 1 (6 months). If a subject became totally disabled, this difference was considered as plus infinity if it occurred in period 1 (Penalizes period 1), and minus infinity if it occurred in Period 2 (Penalizes period 2). The two treatments were compared via the Wilcoxon test, and the effect size was estimated using Kendall's Tau-B. This is interpreted in a similar manner to correlation with positive values favoring COQenzyme10 and negative values favoring placebo. Goggle pedsQL and Mapi to browse the copyrighted manual. A link to the instrument is included." (NCT00432744)
Timeframe: At 6 and 12 Months
| Intervention | units on a scale (Median) |
|---|---|
| Placebo First | -1.1 |
| CoenzymeQ10 Frist | -11.9 |
82 reviews available for lactic acid and Acidosis, Lactic
| Article | Year |
|---|---|
[Hyperlactataemia].
Topics: Acidosis; Acidosis, Lactic; Humans; Lactic Acid | 2021 |
Lactic Acidosis in Patients with Solid Cancer.
Topics: Acidosis, Lactic; Evidence Gaps; Humans; Lactic Acid; Neoplasms; Tumor Microenvironment | 2022 |
Lactic Acidosis Associated with Metformin in Patients with Diabetic Kidney Disease.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Hypoglycemic Agents; La | 2022 |
High risk and low prevalence diseases: Metformin toxicities.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Pr | 2023 |
Demystifying Lactate in the Emergency Department.
Topics: Acidosis, Lactic; Emergency Service, Hospital; Humans; Hyperlactatemia; Lactic Acid; Prognosis; Seps | 2020 |
L-lactic acidosis: pathophysiology, classification, and causes; emphasis on biochemical and metabolic basis.
Topics: Acidosis, Lactic; Anions; Bicarbonates; Citric Acid Cycle; Critical Illness; Electron Transport Chai | 2020 |
Do Patients Die with or from Metformin-Associated Lactic Acidosis (MALA)? Systematic Review and Meta-analysis of pH and Lactate as Predictors of Mortality in MALA.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Aged; Biomarkers; Female; Humans; Hydrogen-Ion Concentratio | 2020 |
Hyperlactatemia: An Update on Postoperative Lactate.
Topics: Acidosis, Lactic; Biomarkers; Cardiac Surgical Procedures; Female; Humans; Hyperlactatemia; Hypoxia; | 2020 |
Osmolar-gap in the setting of metformin-associated lactic acidosis: Case report and a literature review highlighting an apparently unusual association.
Topics: Acid-Base Imbalance; Acidosis, Lactic; Acute Kidney Injury; Diabetes Mellitus, Type 2; Humans; Hypog | 2020 |
Identifying cardiogenic shock in the emergency department.
Topics: Acidosis, Lactic; Bradycardia; Confusion; Early Diagnosis; Echocardiography; Edema; Electrocardiogra | 2020 |
Molecular imaging for mitochondrial metabolism and oxidative stress in mitochondrial diseases and neurodegenerative disorders.
Topics: Acidosis, Lactic; Brain Diseases; Electron Transport; Fatty Acids; Glucose; Humans; Lactic Acid; Mag | 2021 |
Serum lactate level and mortality in metformin-associated lactic acidosis requiring renal replacement therapy: a systematic review of case reports and case series.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Aged; Biomarkers; Female; Humans; Hypoglycemic Agents; | 2017 |
Lactate Levels with Chronic Metformin Use: A Narrative Review.
Topics: Acidosis, Lactic; Humans; Hypoglycemic Agents; Incidence; Lactic Acid; Metformin; Renal Insufficienc | 2017 |
[Metformin-associated lactic acidosis: an insufficiently recognised problem].
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic A | 2017 |
D-lactic acidosis in humans: systematic literature review.
Topics: Acidosis, Lactic; Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Female; Human | 2018 |
Rapid review shows that probiotics and fermented infant formulas do not cause d-lactic acidosis in healthy children.
Topics: Acidosis, Lactic; Child, Preschool; Female; Fermentation; Humans; Infant; Infant Formula; Infant Hea | 2018 |
[Lactic acidosis - update 2018].
Topics: Acidosis, Lactic; Critical Care; Humans; Lactic Acid; Liver Diseases; Metabolic Clearance Rate; Prog | 2018 |
A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure.
Topics: Acidosis, Lactic; Diabetes Mellitus; Drug Administration Schedule; Drug Overdose; Glomerular Filtrat | 2014 |
Lactic acidosis.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Fluid Therapy; Humans; Hyperlactatemia; Lactic Acid; Progno | 2014 |
A case of type B lactic acidosis as a complication of chronic myelomonocytic leukaemia: a case report and review of the literature.
Topics: Acidosis, Lactic; Aged; Antibiotics, Antineoplastic; Doxorubicin; Fatal Outcome; Hematoma, Subdural, | 2015 |
Extracorporeal Treatment for Metformin Poisoning: Systematic Review and Recommendations From the Extracorporeal Treatments in Poisoning Workgroup.
Topics: Acidosis, Lactic; Consciousness; Delphi Technique; Humans; Hydrogen-Ion Concentration; Lactic Acid; | 2015 |
Use of Lactate in Small Animal Clinical Practice.
Topics: Acidosis, Lactic; Animals; Biomarkers; Blood Chemical Analysis; Cats; Diagnosis, Differential; Dogs; | 2015 |
Lactate and its many faces.
Topics: Acidosis, Lactic; Brain Chemistry; Child; Energy Metabolism; Glucose; Humans; Hypoglycemia; Lactic A | 2016 |
[Lactic acidosis in the postictal state].
Topics: Acidosis, Lactic; Adult; Emergency Service, Hospital; Epilepsy; Humans; Incidence; Lactic Acid; Male | 2015 |
Point of Care Measurement of Lactate.
Topics: Acidosis, Lactic; Animals; Cat Diseases; Cats; Dog Diseases; Dogs; Lactic Acid; Point-of-Care Testin | 2016 |
Hyperlactatemia and Cardiac Surgery.
Topics: Acidosis, Lactic; Biomarkers; Cardiac Surgical Procedures; Humans; Hyperlactatemia; Hypoxia; Lactic | 2017 |
Acute metformin overdose: examining serum pH, lactate level, and metformin concentrations in survivors versus nonsurvivors: a systematic review of the literature.
Topics: Acidosis, Lactic; Acute Disease; Adult; Drug Overdose; Female; Humans; Hydrogen-Ion Concentration; H | 2009 |
Blood lactate monitoring in critically ill patients: a systematic health technology assessment.
Topics: Acidosis, Lactic; Algorithms; Critical Care; Decision Support Techniques; Humans; Lactic Acid; Monit | 2009 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Lactic acidosis: recognition, kinetics, and associated prognosis.
Topics: Acidosis, Lactic; Humans; Lactic Acid; Prognosis | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
The role of serum lactate in the acute care setting.
Topics: Acidosis, Lactic; Adult; Aged; Antiretroviral Therapy, Highly Active; Biomarkers; Critical Care; Dru | 2010 |
The interpretation of perioperative lactate abnormalities in patients undergoing cardiac surgery.
Topics: Acidosis, Lactic; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Humans; Lactic Acid; Myocardi | 2012 |
The interpretation of perioperative lactate abnormalities in patients undergoing cardiac surgery.
Topics: Acidosis, Lactic; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Humans; Lactic Acid; Myocardi | 2012 |
The interpretation of perioperative lactate abnormalities in patients undergoing cardiac surgery.
Topics: Acidosis, Lactic; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Humans; Lactic Acid; Myocardi | 2012 |
The interpretation of perioperative lactate abnormalities in patients undergoing cardiac surgery.
Topics: Acidosis, Lactic; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Humans; Lactic Acid; Myocardi | 2012 |
The interpretation of perioperative lactate abnormalities in patients undergoing cardiac surgery.
Topics: Acidosis, Lactic; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Humans; Lactic Acid; Myocardi | 2012 |
The interpretation of perioperative lactate abnormalities in patients undergoing cardiac surgery.
Topics: Acidosis, Lactic; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Humans; Lactic Acid; Myocardi | 2012 |
The interpretation of perioperative lactate abnormalities in patients undergoing cardiac surgery.
Topics: Acidosis, Lactic; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Humans; Lactic Acid; Myocardi | 2012 |
The interpretation of perioperative lactate abnormalities in patients undergoing cardiac surgery.
Topics: Acidosis, Lactic; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Humans; Lactic Acid; Myocardi | 2012 |
The interpretation of perioperative lactate abnormalities in patients undergoing cardiac surgery.
Topics: Acidosis, Lactic; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Humans; Lactic Acid; Myocardi | 2012 |
Ergogenic effects of β-alanine and carnosine: proposed future research to quantify their efficacy.
Topics: Acidosis, Lactic; beta-Alanine; Carnosine; Dietary Supplements; Exercise; Fatigue; Humans; Lactic Ac | 2012 |
Trauma and aggressive homeostasis management.
Topics: Acidosis, Lactic; Brain Injuries; Homeostasis; Humans; Hyperglycemia; Hypothermia, Induced; Insulin; | 2013 |
[Positional paper of the German working group "cardiopulmonary exercise testing" to ventilatory and metabolic (lactate) thresholds].
Topics: Acidosis; Acidosis, Lactic; Anaerobic Threshold; Carbon Dioxide; Exercise Test; Germany; Humans; Lac | 2013 |
Lactate, glucose and energy metabolism in the ischemic brain (Review).
Topics: Acidosis, Lactic; Anaerobiosis; Animals; Brain; Brain Damage, Chronic; Brain Ischemia; Corticosteron | 2002 |
[Lactate . pyruvate].
Topics: Acidosis, Lactic; Biomarkers; Diabetes Mellitus; Humans; Lactic Acid; Neoplasms; Pyruvic Acid | 2002 |
Metabolic acidosis: separation methods and biological relevance of organic acids and lactic acid enantiomers.
Topics: Acidosis, Lactic; Acids; Animals; Chromatography, Gas; Chromatography, Liquid; Humans; Lactic Acid; | 2002 |
Emerging drug toxicities of highly active antiretroviral therapy for human immunodeficiency virus (HIV) infection.
Topics: Acidosis, Lactic; Antiretroviral Therapy, Highly Active; Bone Diseases, Metabolic; DNA, Mitochondria | 2003 |
Bench-to-bedside review: severe lactic acidosis in HIV patients treated with nucleoside analogue reverse transcriptase inhibitors.
Topics: Acidosis, Lactic; Adult; Anti-HIV Agents; Carnitine; HIV Infections; Humans; Lactic Acid; Mitochondr | 2003 |
Effects of prior exercise on metabolic and gas exchange responses to exercise.
Topics: Acidosis, Lactic; Electromyography; Exercise; Exercise Tolerance; Humans; Lactic Acid; Muscle Fibers | 2003 |
Lactate metabolism: a new paradigm for the third millennium.
Topics: Acidosis, Lactic; Animals; Energy Metabolism; Exercise; Humans; Lactic Acid | 2004 |
Lactate metabolism: a new paradigm for the third millennium.
Topics: Acidosis, Lactic; Animals; Energy Metabolism; Exercise; Humans; Lactic Acid | 2004 |
Lactate metabolism: a new paradigm for the third millennium.
Topics: Acidosis, Lactic; Animals; Energy Metabolism; Exercise; Humans; Lactic Acid | 2004 |
Lactate metabolism: a new paradigm for the third millennium.
Topics: Acidosis, Lactic; Animals; Energy Metabolism; Exercise; Humans; Lactic Acid | 2004 |
Biochemistry of exercise-induced metabolic acidosis.
Topics: Acidosis; Acidosis, Lactic; Animals; Buffers; Exercise; History, 18th Century; History, 20th Century | 2004 |
[Progress in diagnosis of and therapy for diabetic lactic acidosis].
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Blood Gas Analysis; Consciousness Disorders; Diabetes Compl | 2004 |
Surviving extreme lactic acidosis: the role of calcium lactate formation in the anoxic turtle.
Topics: Acidosis, Lactic; Adaptation, Physiological; Animals; Bone and Bones; Calcium; Calcium Compounds; Hu | 2004 |
D(-)-lactic acid-producing probiotics, D(-)-lactic acidosis and infants.
Topics: Acidosis, Lactic; Bifidobacterium; Child Development; Humans; Infant; Lactic Acid; Lactobacillus; Pr | 2004 |
Hyperlactataemia and lactic acidosis in HIV-infected patients receiving antiretroviral therapy.
Topics: Acidosis, Lactic; Anti-HIV Agents; HIV Infections; Humans; Lactic Acid; Nucleosides; Prevalence; Rev | 2005 |
The role of hepatitis C virus (HCV) in mitochondrial DNA damage in HIV/HCV-coinfected individuals.
Topics: Acidosis, Lactic; Anti-HIV Agents; Antiviral Agents; DNA Damage; DNA, Mitochondrial; Hepatitis C; HI | 2005 |
Symptomatic hyperlactataemia and lactic acidosis in the era of highly active antiretroviral therapy.
Topics: Acidosis, Lactic; Antiretroviral Therapy, Highly Active; HIV Infections; Humans; Lactic Acid; Revers | 2005 |
Lactic acid and exercise performance : culprit or friend?
Topics: Acidosis, Lactic; Animals; Exercise Tolerance; Humans; Lactic Acid; Muscle Contraction; Muscle Fatig | 2006 |
[Diabetic lactic acidosis].
Topics: Acidosis, Lactic; Contraindications; Diabetic Ketoacidosis; Humans; Hypoglycemic Agents; Insulin; La | 2006 |
D-Lactic acidosis in calves.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Animals; Animals, Newborn; Blood Gas Analysis; Cattle; Catt | 2009 |
Risk factors for lactic acidosis and severe hyperlactataemia in HIV-1-infected adults exposed to antiretroviral therapy.
Topics: Acidosis, Lactic; Adult; Age Factors; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Ly | 2007 |
Lactic acidosis in paediatrics: clinical and laboratory evaluation.
Topics: Acidosis, Lactic; Adult; Child; Citric Acid Cycle; Female; Gluconeogenesis; Glycogen; Humans; Infant | 1994 |
Coupling of external to cellular respiration during exercise: the wisdom of the body revisited.
Topics: Acidosis, Lactic; Animals; Bicarbonates; Buffers; Capillaries; Carbon Dioxide; Humans; Lactates; Lac | 1994 |
Metformin and intestinal glucose handling.
Topics: Acidosis, Lactic; Animals; Diabetes Mellitus, Type 2; Glucose; Humans; Hypoglycemic Agents; Intestin | 1995 |
[Is sepsis and septic shock due to a global oxygen insufficiency? A review in 2 parts. 2: Sepsis and lactate].
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Humans; Lactates; Lactic Acid; Oxygen; Risk Factors; Shock, | 1996 |
[Lactic acid].
Topics: Acidosis, Lactic; Humans; Lactates; Lactic Acid | 1995 |
D-lactic acidosis: turning sugar into acids in the gastrointestinal tract.
Topics: Acidosis, Lactic; Animals; Digestive System; Humans; Lactic Acid | 1996 |
Fetal monitoring with lactate.
Topics: Acidosis, Lactic; Blood Specimen Collection; Fetal Blood; Fetal Hypoxia; Fetal Monitoring; Humans; L | 1996 |
Buffers: bicarbonate, lactate and pyruvate.
Topics: Acidosis, Lactic; Bicarbonates; Buffers; Dialysis Solutions; Humans; Lactic Acid; Peritoneal Dialysi | 1996 |
Bovine acidosis: implications on laminitis.
Topics: Acidosis, Lactic; Animal Nutritional Physiological Phenomena; Animals; Cattle; Cattle Diseases; Derm | 1997 |
Lactate and short chain fatty acid production in the human colon: implications for D-lactic acidosis, short-bowel syndrome, antibiotic-associated diarrhoea, colonic cancer, and inflammatory bowel disease.
Topics: Acidosis, Lactic; Animals; Colon; Colonic Neoplasms; Diarrhea; Fatty Acids, Volatile; Humans; Intest | 1998 |
D-lactic acidosis. A review of clinical presentation, biochemical features, and pathophysiologic mechanisms.
Topics: Acidosis, Lactic; Adolescent; Adult; Age Distribution; Child; Child, Preschool; Feces; Female; Human | 1998 |
Metabolic acidosis in the critically ill: lessons from physical chemistry.
Topics: Acid-Base Equilibrium; Acidosis; Acidosis, Lactic; Carbon Dioxide; Chemical Phenomena; Chemistry, Ph | 1998 |
D-lactic acidosis: pathologic consequence of saprophytism.
Topics: Acidosis, Lactic; Diagnosis, Differential; Female; Humans; Intestines; Lactic Acid; Middle Aged | 1998 |
Lactate in sepsis and trauma--hindrance or help?
Topics: Acidosis, Lactic; Biomarkers; Humans; Lactic Acid; Sepsis; Wounds and Injuries | 1999 |
Unmeasured anions: déjà vu all over again?
Topics: Acidosis, Lactic; Bias; Blood Gas Analysis; Child; Critical Care; Critical Illness; Electrolytes; Hu | 1999 |
Dysoxia and lactate.
Topics: Acidosis, Lactic; Adult; Cell Hypoxia; Child; Critical Illness; Forecasting; Humans; Lactic Acid; Ox | 1999 |
Reaction of lactate electrodes to glycolate.
Topics: Acidosis, Lactic; Biosensing Techniques; Coated Materials, Biocompatible; Ethylene Glycol; Glycolate | 1999 |
[Biochemistry of cerebral ischemia].
Topics: Acidosis, Lactic; Brain; Brain Ischemia; Calcium Channels; Cerebrovascular Circulation; Humans; Lact | 1999 |
[Serum lactate level as a indicator of tissue hypoxia in severely ill patients].
Topics: Acid-Base Imbalance; Acidosis, Lactic; Cell Hypoxia; Fluid Therapy; Humans; Lactic Acid; Severity of | 2000 |
[Threshold parameters in clinical practice].
Topics: Acid-Base Equilibrium; Acid-Base Imbalance; Acidosis, Lactic; Anaerobic Threshold; Diagnosis, Differ | 2000 |
Epinephrine and gut lactate production.
Topics: Acidosis, Lactic; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Epinephrine; Humans; | 2001 |
Hodgkin's disease and lactic acidosis.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Fatal Outcome; Hodgkin Disease; Humans; Lactic Acid; Live | 2001 |
Lactate doesn't necessarily cause fatigue: why are we surprised?
Topics: Acidosis, Lactic; Fatigue; Humans; Lactic Acid | 2001 |
Lactic acidosis in critical illness.
Topics: Acidosis, Lactic; Bicarbonates; Blood Gas Analysis; Carbonates; Citric Acid Cycle; Critical Illness; | 1992 |
[Lactic acidosis].
Topics: Acidosis, Lactic; Humans; Lactates; Lactic Acid | 1992 |
Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis.
Topics: Acidosis, Lactic; Animals; Blood Gas Analysis; Cell Hypoxia; Energy Metabolism; Fluorine Radioisotop | 1992 |
Effects of various doses of sodium dichloroacetate on hyperlactatemia in fed ischemic rats.
Topics: Acetates; Acidosis, Lactic; Animals; Brain Chemistry; Brain Ischemia; Dichloroacetic Acid; Disease M | 1989 |
[Neonatal lactic acidosis caused by severe pyruvate carboxylase deficiency].
Topics: Acidosis, Lactic; Humans; Infant; Infant, Newborn; Lactates; Lactic Acid; Male; Metabolism, Inborn E | 1988 |
31 trials available for lactic acid and Acidosis, Lactic
| Article | Year |
|---|---|
A case risk study of lactic acidosis risk by metformin use in type 2 diabetes mellitus tuberculosis coinfection patients.
Topics: Acidosis, Lactic; Adult; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Lactic Acid | 2018 |
Lactate acidosis and cardiac output during initial therapeutic cooling in asphyxiated newborn infants.
Topics: Acidosis, Lactic; Asphyxia Neonatorum; Cardiac Output; Female; Humans; Hypothermia, Induced; Infant, | 2019 |
[Treatment of lactic acidosis with early continuous blood purification].
Topics: Acidosis, Lactic; Aged; APACHE; Female; Hemofiltration; Humans; Lactic Acid; Male; Middle Aged; Pros | 2013 |
Beneficial effect of fenoldopam mesylate in preventing peak blood lactate level during cardiopulmonary bypass for paediatric cardiac surgery.
Topics: Acidosis, Lactic; Age Factors; Biomarkers; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Chil | 2014 |
Lactate Clearance and Vasopressor Seem to Be Predictors for Mortality in Severe Sepsis Patients with Lactic Acidosis Supplementing Sodium Bicarbonate: A Retrospective Analysis.
Topics: Acidosis, Lactic; Aged; C-Reactive Protein; Female; Hospital Mortality; Humans; Lactic Acid; Male; M | 2015 |
Inspiratory loading intensity does not influence lactate clearance during recovery.
Topics: Acidosis, Lactic; Adult; Area Under Curve; Bicycling; Breathing Exercises; Exercise Test; Humans; Hy | 2012 |
Risk factors for symptomatic hyperlactatemia and lactic acidosis among combination antiretroviral therapy-treated adults in Botswana: results from a clinical trial.
Topics: Acidosis, Lactic; Adult; Anti-Retroviral Agents; Botswana; Drug Therapy, Combination; Female; Follow | 2012 |
Lactate production as a response to intrapartum hypoxia in the growth-restricted fetus.
Topics: Acidosis, Lactic; Adult; Birth Weight; Female; Fetal Blood; Fetal Growth Retardation; Fetal Hypoxia; | 2012 |
The effect of blood storage age on treatment of lactic acidosis by transfusion in children with severe malarial anaemia: a pilot, randomized, controlled trial.
Topics: Acidosis, Lactic; Blood Transfusion; Child, Preschool; Drug Storage; Female; Hemoglobins; Humans; In | 2013 |
Detecting life-threatening lactic acidosis related to nucleoside-analog treatment of human immunodeficiency virus-infected patients, and treatment with L-carnitine.
Topics: Acidosis, Lactic; Adult; Antiviral Agents; Carnitine; Female; HIV Infections; Humans; Lactic Acid; M | 2003 |
Cerebral lactic acidosis correlates with neurological impairment in MELAS.
Topics: Acidosis, Lactic; Adult; Blood Glucose; Cerebral Ventricles; Chronic Disease; DNA Mutational Analysi | 2004 |
Lactic acidosis after cardiac surgery is associated with adverse outcome.
Topics: Acidosis, Lactic; Coronary Artery Bypass; Female; Humans; Incidence; Lactic Acid; Male; Middle Aged; | 2004 |
NaHCO3-induced alkalosis reduces the phosphocreatine slow component during heavy-intensity forearm exercise.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Adenosine Diphosphate; Adenosine Triphosphate; Adult; Alkal | 2005 |
Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate.
Topics: Acidosis, Lactic; Administration, Oral; Adolescent; Adult; Child; Child, Preschool; Dichloroacetic A | 2008 |
Determination of pH or lactate in fetal scalp blood in management of intrapartum fetal distress: randomised controlled multicentre trial.
Topics: Acidosis, Lactic; Female; Fetal Blood; Fetal Distress; Fetal Hypoxia; Fetal Monitoring; Fetus; Human | 2008 |
Pharmacokinetics and pharmacodynamics of dichloroacetate in children with lactic acidosis due to severe malaria.
Topics: Acidosis, Lactic; Child; Child, Preschool; Dichloroacetic Acid; Drug Therapy, Combination; Female; H | 1995 |
Amelioration of lactic acidosis with dichloroacetate during liver transplantation in humans.
Topics: Acidosis, Lactic; Adult; Blood Glucose; Dichloroacetic Acid; Female; Humans; Hydrogen-Ion Concentrat | 1994 |
Natural history and course of acquired lactic acidosis in adults. DCA-Lactic Acidosis Study Group.
Topics: Acidosis, Lactic; Adult; Aged; Female; Humans; Lactates; Lactic Acid; Male; Middle Aged; Predictive | 1994 |
Safety of low-dose intraoperative bicarbonate therapy: a prospective, double-blind, randomized study. The Study of Perioperative Ischemia (SPI) Research Group.
Topics: Acidosis, Lactic; Aged; Bicarbonates; Blood Gas Analysis; Blood Glucose; Calcium; Cardiac Output; Co | 1993 |
Intravenous almitrine bismesylate reversibly induces lactic acidosis and hepatic dysfunction in patients with acute lung injury.
Topics: Acidosis, Lactic; Acute Disease; Adolescent; Adult; Aged; Almitrine; Analysis of Variance; Bilirubin | 1998 |
Evaluation of a new, rapid lactate analyzer in critical care.
Topics: Acidosis, Lactic; Analysis of Variance; Blood Gas Analysis; Humans; Intensive Care Units; Lactic Aci | 1999 |
Glucose and lactate kinetics in children with severe malaria.
Topics: Acidosis, Lactic; Antimalarials; Artemisinins; Artesunate; Blood Glucose; Child; Child, Preschool; D | 2000 |
Arterial hypoxaemia in endurance athletes is greater during running than cycling.
Topics: Acidosis, Lactic; Adult; Arteries; Blood Gas Analysis; Exercise Test; Humans; Hydrogen-Ion Concentra | 2000 |
Symptomatic hyperlactataemia: an emerging complication of antiretroviral therapy.
Topics: Acidosis, Lactic; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyt | 2000 |
High levels of lactic acid in some users of HAART.
Topics: Acidosis, Lactic; Adult; Antiretroviral Therapy, Highly Active; Female; HIV Infections; Humans; Lact | 2001 |
Effect of an acute beta-adrenergic blockade on the blood glucose response during lactate minimum test.
Topics: Acidosis, Lactic; Adrenergic beta-Antagonists; Adult; Blood Glucose; Double-Blind Method; Exercise; | 2001 |
Lactic acidosis, potassium, and the heart rate deflection point in professional road cyclists.
Topics: Acidosis, Lactic; Adult; Anaerobic Threshold; Bicycling; Exercise; Exercise Test; Heart Rate; Humans | 2002 |
Ventilatory and metabolic changes as a result of exercise training in COPD patients.
Topics: Acidosis, Lactic; Adult; Anaerobic Threshold; Exercise Test; Exercise Therapy; Humans; Lactates; Lac | 1992 |
Ventilatory and metabolic changes as a result of exercise training in COPD patients.
Topics: Acidosis, Lactic; Adult; Anaerobic Threshold; Exercise Test; Exercise Therapy; Humans; Lactates; Lac | 1992 |
Ventilatory and metabolic changes as a result of exercise training in COPD patients.
Topics: Acidosis, Lactic; Adult; Anaerobic Threshold; Exercise Test; Exercise Therapy; Humans; Lactates; Lac | 1992 |
Ventilatory and metabolic changes as a result of exercise training in COPD patients.
Topics: Acidosis, Lactic; Adult; Anaerobic Threshold; Exercise Test; Exercise Therapy; Humans; Lactates; Lac | 1992 |
Lactate or bicarbonate for intermittent hemofiltration?
Topics: Acidosis, Lactic; Acute Kidney Injury; Bicarbonates; Buffers; Female; Hemodialysis Solutions; Hemofi | 1991 |
Effect of consecutive exercise bouts on plasma potassium concentration during exercise and recovery.
Topics: Acidosis, Lactic; Adolescent; Adult; Bicarbonates; Clinical Trials as Topic; Exercise; Humans; Hydro | 1989 |
Effect of dichloroacetate on the exercise performance of patients with heart failure.
Topics: Acetates; Acidosis, Lactic; Adult; Aged; Dichloroacetic Acid; Exercise; Fatigue; Heart Failure; Huma | 1988 |
518 other studies available for lactic acid and Acidosis, Lactic
| Article | Year |
|---|---|
l-lactic acidosis confers insensitivity to PKC inhibitors by competing for uptake via monocarboxylate transporters.
Topics: Acidosis, Lactic; Carcinoma, Non-Small-Cell Lung; ErbB Receptors; Humans; Lactic Acid; Lung Neoplasm | 2022 |
Patients with Severe Lactic Acidosis in the Intensive Care Unit: A Retrospective Study of Contributing Factors and Impact of Renal Replacement Therapy.
Topics: Acidosis, Lactic; Acute Kidney Injury; Humans; Hyperlactatemia; Intensive Care Units; Lactic Acid; R | 2022 |
Acetoacetate protects macrophages from lactic acidosis-induced mitochondrial dysfunction by metabolic reprograming.
Topics: Acetoacetates; Acidosis, Lactic; Cellular Reprogramming; Energy Metabolism; Gene Expression; Humans; | 2021 |
Type B lactic acidosis associated with diffuse large B-cell lymphoma and the Warburg effect.
Topics: Acidosis, Lactic; Adult; Humans; Hypoglycemia; Lactic Acid; Lymphoma, Large B-Cell, Diffuse; Male; P | 2022 |
Unexplained Metabolic Acidosis: Alcoholic Ketoacidosis or Propylene Glycol Toxicity.
Topics: Acidosis; Acidosis, Lactic; Ethanol; Ethylene Glycol; Female; Humans; Ketosis; Lactic Acid; Methanol | 2022 |
Reduced lactic acidosis risk with Imeglimin: Comparison with Metformin.
Topics: Acidosis, Lactic; Animals; Diabetes Mellitus, Type 2; Dogs; Humans; Hypoglycemic Agents; Lactic Acid | 2022 |
Allosteric transitions of rabbit skeletal muscle lactate dehydrogenase induced by pH-dependent dissociation of the tetrameric enzyme.
Topics: Acidosis, Lactic; Animals; Citrates; Hydrogen-Ion Concentration; Kinetics; L-Lactate Dehydrogenase; | 2022 |
D-lactic acidosis - a rare complication of short bowel syndrome.
Topics: Acidosis; Acidosis, Lactic; Female; Humans; Lactic Acid; Middle Aged; Short Bowel Syndrome | 2021 |
Association Between the Acidemia, Lactic Acidosis, and Shock Severity With Outcomes in Patients With Cardiogenic Shock.
Topics: Acidosis; Acidosis, Lactic; Aged; Cohort Studies; Female; Humans; Lactic Acid; Male; Shock; Shock, C | 2022 |
Linezolid Intoxication with Extreme Lactate Blood Levels Successfully Treated with Dialytic Treatment in ICU: A Case Report.
Topics: Acidosis, Lactic; Aged; Anti-Bacterial Agents; Female; Humans; Lactic Acid; Linezolid; Renal Dialysi | 2022 |
Resistant Lactic Acidemia Due to Accidental Cheese Starter Culture Ingestion.
Topics: Acidosis, Lactic; Adult; Cheese; Child; Eating; Humans; Lactic Acid; Short Bowel Syndrome | 2022 |
Sufentanil: a risk factor for lactic acidosis in patients after heart valve surgery.
Topics: Acidosis, Lactic; Analgesics, Opioid; Cardiac Surgical Procedures; Epinephrine; Heart Valves; Humans | 2022 |
Hyperglycemia and Lactic Acidosis Associated with Linezolid Therapy in an Extremely Premature Infant.
Topics: Acidosis, Lactic; Cesarean Section; Female; Glucose; Humans; Infant, Extremely Premature; Infant, Ne | 2022 |
Development of a prehospital lactic acidosis score for early-mortality. A prospective, multicenter, ambulance-based, cohort study.
Topics: Acidosis, Lactic; Adult; Ambulances; Cohort Studies; Emergency Medical Services; Hospital Mortality; | 2023 |
Metformin-associated severe lactic acidosis combined with multi-organ insufficiency induced by infection with Aeromonas veronii: A case report.
Topics: Acidosis, Lactic; Aeromonas veronii; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic A | 2023 |
Mitochondrial toxicity induced by linezolid causing lactic acidosis.
Topics: Acidosis, Lactic; Humans; Lactic Acid; Linezolid | 2023 |
Extracellular Lactic Acidosis of the Tumor Microenvironment Drives Adipocyte-to-Myofibroblast Transition Fueling the Generation of Cancer-Associated Fibroblasts.
Topics: Acidosis, Lactic; Adipocytes; Cancer-Associated Fibroblasts; Endothelial Cells; Humans; Lactic Acid; | 2023 |
Unmeasured Organic Anions as Predictors of Clinical Outcomes in Lactic Acidosis due to Sepsis.
Topics: Acidosis, Lactic; Adult; Albumins; Anions; Humans; Lactic Acid; Retrospective Studies; ROC Curve; Se | 2023 |
Metformin-associated lactic acidosis reported to the United Kingdom National Poisons Information Service (NPIS) between 2010 and 2019: a ten-year retrospective analysis.
Topics: Acidosis, Lactic; Drug Overdose; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Poisons; Retro | 2023 |
Laboratory medicine unveiling an unusual cause of D-lactic acidosis as the trigger of decompensation of a rare inborn error of metabolism.
Topics: Acidosis, Lactic; Humans; Lactic Acid | 2023 |
Α rare case of myopathy, lactic acidosis, and severe rhabdomyolysis, due to a homozygous mutation of the ferredoxin-2 (FDX2) gene.
Topics: Acidosis, Lactic; Cell Cycle Proteins; Child; Cytoskeletal Proteins; Female; Ferredoxins; Humans; La | 2023 |
Clinical presentation of Warburg effect in aggressive lymphoma: a case report.
Topics: Acidosis, Lactic; Aged; Aggression; Cognition; Female; Humans; Lactic Acid; Lymphoma, Large B-Cell, | 2023 |
Warburg-associated acidification represses lactic fermentation independently of lactate, contribution from real-time NMR on cell-free systems.
Topics: Acidosis, Lactic; Cell-Free System; Fermentation; Glucose; Glycolysis; Humans; Hydrogen-Ion Concentr | 2023 |
Treatment of severe metformin-associated lactic acidosis with renal replacement therapy and tris-hydroxymethyl aminomethane: a case report.
Topics: Acidosis, Lactic; Adult; Carbon Dioxide; Continuous Renal Replacement Therapy; Humans; Hypoglycemic | 2023 |
Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Topics: Acidosis, Lactic; Animals; Binding Sites; Humans; Hydroxy Acids; L-Lactate Dehydrogenase; Lactate De | 2023 |
B-cell hepatosplenic lymphoma presenting in adult patient after spontaneous splenic rupture followed by severe persistent hypoglycaemia: type B lactic acidosis and acute liver failure.
Topics: Acidosis, Lactic; Adult; Humans; Hypoglycemia; Lactic Acid; Liver Failure, Acute; Lymphoma, Non-Hodg | 2023 |
Misdiagnosis of high anion gap acidosis owing to instrument error of a device.
Topics: Acid-Base Equilibrium; Acidosis; Acidosis, Lactic; Aged; Albumins; Bicarbonates; Blood Chemical Anal | 2019 |
A Case of Lung Involvement in Peripheral T Cell Lymphoma.
Topics: Acidosis, Lactic; Adult; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Cyclophosphamide; D | 2019 |
Laboratory-Confirmed Metformin-Associated Lactic Acidosis
Topics: Acidosis, Lactic; Aged; Alcohol Drinking; Continuous Renal Replacement Therapy; Diabetes Mellitus, T | 2019 |
Role of lactic acidosis as a mediator of sprint-mediated nausea.
Topics: Acidosis, Lactic; Adult; Bicarbonates; Carbon Dioxide; Humans; Hydrogen-Ion Concentration; Lactic Ac | 2019 |
High anion gap metabolic acidosis caused by D-lactate: mind the time of blood collection.
Topics: Acidosis; Acidosis, Lactic; Adult; False Positive Reactions; Female; Gas Chromatography-Mass Spectro | 2020 |
The safety and pharmacokinetics of metformin in patients with chronic liver disease.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Chronic Disease; Comorbidity; Cross-Sectional Stud | 2020 |
Lactic acidosis induces resistance to the pan-Akt inhibitor uprosertib in colon cancer cells.
Topics: Acidosis, Lactic; Angiogenesis Inhibitors; Apoptosis; Colonic Neoplasms; Diamines; Drug Resistance, | 2020 |
The Effect of Residual Confoundingon Mortality in Metformin-Associated Lactic Acidosis.
Topics: Acidosis, Lactic; Humans; Hydrogen-Ion Concentration; Lactic Acid; Metformin; Risk Factors | 2020 |
Is Lactic Acidosis After Lung Transplantation Associated With Worse Outcomes?
Topics: Acidosis, Lactic; Airway Extubation; Female; Humans; Lactic Acid; Lung Transplantation; Male; Middle | 2020 |
In Reply: More Questions than Answers in Metformin-Associated Lactic Acidosis (MALA).
Topics: Acidosis, Lactic; Humans; Hydrogen-Ion Concentration; Lactic Acid; Metformin; Risk Factors | 2020 |
Long-term high-grain diet alters ruminal pH, fermentation, and epithelial transcriptomes, leading to restored mitochondrial oxidative phosphorylation in Japanese Black cattle.
Topics: Acidosis, Lactic; Animal Feed; Animals; Cattle; Diet; Edible Grain; Fatty Acids, Volatile; Fermentat | 2020 |
Lactic Acidosis after Drinking Mysterious Beverage.
Topics: Acidosis, Lactic; Beverages; Ethylene Glycol; Humans; Lactic Acid; Poisoning | 2020 |
[An acidosis not so basic].
Topics: Acid-Base Equilibrium; Acidosis; Acidosis, Lactic; Blood Chemical Analysis; Child, Preschool; Coma; | 2020 |
Novel metabolic system for lactic acid via LRPGC1/ERRγ signaling pathway.
Topics: Acidosis, Lactic; Active Transport, Cell Nucleus; Animals; Cell Nucleus; Chlorocebus aethiops; COS C | 2020 |
Metformin-associated lactic acidosis: reinforcing learning points.
Topics: Acidosis, Lactic; Acute Kidney Injury; Bicarbonates; Continuous Renal Replacement Therapy; Diabetes | 2020 |
[Lactic Acidosis and Other Misunderstandings].
Topics: Acidosis; Acidosis, Lactic; Biomarkers; Critical Care; Humans; Lactic Acid | 2020 |
Fetal scalp blood sampling: Do pH and lactates provide the same information?
Topics: Acidosis, Lactic; Adult; Amniotic Fluid; Female; Fetal Blood; Humans; Hydrogen-Ion Concentration; In | 2021 |
Salbutamol-induced lactic acidosis in status asthmaticus survivor.
Topics: Acidosis; Acidosis, Lactic; Acidosis, Respiratory; Adrenergic beta-2 Receptor Agonists; Adult; Albut | 2021 |
The usefulness of measuring the anion gap in diagnosing metformin-associated lactic acidosis: a case series.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Aged; Aged, 80 and over; Anions; Cations; Diabetes Mellitus | 2021 |
Spurious point-of-care lactate elevation in ethylene glycol intoxication: rediscovering a clinical pearl.
Topics: Acidosis, Lactic; Aged; Antidotes; Ethylene Glycol; Fomepizole; Humans; Lactic Acid; Male; Renal Rep | 2021 |
Cholinergic and metabolic effects of metformin in mouse brain.
Topics: Acetylcholine; Acidosis, Lactic; Animals; Choline; Glucose; Hypoglycemic Agents; Hypothalamus; Lacti | 2021 |
Plasma Metformin Levels at Almost 24 Hours Would Help With the Delicate Decision to Start Renal Replacement Therapy: We Disagree as Lactate That Is More Widely and Early Available Should Be a Much Better Trigger to Start Renal Replacement Therapy!
Topics: Acidosis, Lactic; Humans; Lactic Acid; Metformin; Renal Replacement Therapy | 2021 |
Evolving cutoff values of "hyperlactatemia" and the role of infection.
Topics: Acidosis, Lactic; Humans; Hyperlactatemia; Lactic Acid; Sepsis; Shock, Septic | 2017 |
Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells.
Topics: Acidosis, Lactic; Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Connexin 43; Gap Junction | 2017 |
Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Case-Control Studies; Diabetes Melli | 2017 |
Metformin Does Not Induce Hyperlactatemia in Patients Admitted to Internal Medicine Ward.
Topics: Acidosis, Lactic; Contraindications, Drug; Diabetes Mellitus; Hospitalization; Humans; Hyperlactatem | 2017 |
Low sensitivity of anion gap to detect clinically significant lactic acidosis in the emergency department.
Topics: Acidosis, Lactic; Blood Chemical Analysis; Emergency Service, Hospital; Female; Humans; Lactic Acid; | 2017 |
Lactate serum concentrations during treatment with nucleos(t)ide analogues in hepatitis B with or without cirrhosis.
Topics: Acidosis, Lactic; Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Biomarkers; Drug Therap | 2017 |
Peripheral venoarterial extracorporeal membrane oxygenation for severe hyperlactataemia after cardiac surgery: a pilot study.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Alanine Transaminase; Cardiac Surgical Procedures; Case-C | 2017 |
Risk of Metformin-Associated Lactic Acidosis (MALA) in Patients After Gastric Bypass Surgery.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Female; Gastric Bypass; Humans; Hypoglycemic Agents; La | 2018 |
Safety of Metformin Therapy in Patients with Type 2 Diabetes Living on an Oxygen-Deficient Plateau, Tibet, China.
Topics: Acidosis, Lactic; Adult; Altitude; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Human | 2018 |
Severe type B lactic acidosis and insulin-resistant hyperglycemia related to cadaveric kidney transplantation.
Topics: Acidosis, Lactic; Blood Glucose; Hemofiltration; Humans; Hyperglycemia; Insulin; Kidney Failure, Chr | 2018 |
Comparative analysis of lactic acidosis induced by linezolid and vancomycin therapy using cohort and case-control studies of incidence and associated risk factors.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Aged; Aged, 80 and over; Anti-Bacterial Agents; Biomarkers; | 2018 |
Type B lactic acidosis, an uncommon paraneoplastic syndrome.
Topics: Acidosis, Lactic; Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Bone Marrow; Humans; | 2018 |
Use of Lactate Pro
Topics: Acidosis, Lactic; Adolescent; Adult; Cross-Sectional Studies; Female; Fetal Monitoring; Humans; Lact | 2019 |
Impact of lactic acidosis on the survival of Lewis lung carcinoma cells.
Topics: Acidosis, Lactic; Animals; Carcinoma, Lewis Lung; Cell Cycle; Cell Line, Tumor; Cell Survival; Cells | 2017 |
Stoned-A Syndrome of D-Lactic Acidosis and Urolithiasis.
Topics: Acidosis, Lactic; Adolescent; Dysbiosis; Feces; Female; Gastrointestinal Microbiome; Humans; Infant; | 2018 |
[Dietetic treatment with fructose in a 5-year-old girl with recurrent D-lactic acidosis].
Topics: Acidosis, Lactic; Child, Preschool; Diet, Carbohydrate-Restricted; Enteral Nutrition; Female; Fructo | 2018 |
Metabolic acidosis in short bowel syndrome: think D-lactic acid acidosis.
Topics: Acidosis, Lactic; Aged; Anti-Infective Agents; C-Reactive Protein; Humans; Lactic Acid; Male; Parent | 2018 |
Assessment of lactate production as a response to sustained intrapartum hypoxia in large-for-gestational-age newborns.
Topics: Acidosis, Lactic; Birth Weight; Diabetes, Gestational; Female; Fetal Blood; Fetal Hypoxia; Fetal Mac | 2018 |
Intestinal Microbial and Metabolic Alterations Following Successful Fecal Microbiota Transplant for D-Lactic Acidosis.
Topics: Acidosis, Lactic; Child; Fecal Microbiota Transplantation; Female; Gastrointestinal Microbiome; Huma | 2018 |
Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Blind Loop Syndrome; Breath | 2018 |
D-lactic Acidosis: Successful Suppression of D-lactate-Producing
Topics: Acidosis, Lactic; Anti-Bacterial Agents; Feces; Gastrointestinal Microbiome; Humans; Infant; Lactic | 2018 |
Involvement of organic cation transporter 2 in the metformin-associated increased lactate levels caused by contrast-induced nephropathy.
Topics: Acidosis, Lactic; Acute Kidney Injury; Animals; Cell Line; Contrast Media; Disease Models, Animal; H | 2018 |
Lactic Acidosis in a Critically Ill Patient: Not Always Sepsis.
Topics: Acidosis, Lactic; Antineoplastic Agents; Child; Critical Illness; Diagnosis, Differential; Fatal Out | 2018 |
Spectroscopic detection of brain propylene glycol in neonates: Effects of different pharmaceutical formulations of phenobarbital.
Topics: Acidosis, Lactic; Brain; Drug Compounding; Female; Humans; Infant, Newborn; Intensive Care, Neonatal | 2019 |
Mitochondrial gene sequence variants in children with severe malaria anaemia with or without lactic acidosis: a case control study.
Topics: Acidosis, Lactic; Anemia; Case-Control Studies; Child, Preschool; DNA, Mitochondrial; Female; Humans | 2018 |
Biomarkers and clinical rating scales for sodium pyruvate therapy in patients with mitochondrial disease.
Topics: Acidosis, Lactic; Adolescent; Adult; Biomarkers; Female; Fibroblast Growth Factors; Growth Different | 2019 |
Identification of human D lactate dehydrogenase deficiency.
Topics: Acidosis, Lactic; Adult; Animals; Consanguinity; Diagnosis, Differential; Homozygote; Humans; Infant | 2019 |
Lactic acidosis due to metformin in type 2 diabetes mellitus and chronic kidney disease stage 3-5: is it significant?
Topics: Acidosis, Lactic; Creatinine; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Moni | 2019 |
Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose.
Topics: Acetaminophen; Acidosis, Lactic; Analgesics, Non-Narcotic; Case-Control Studies; Drug Overdose; Emer | 2019 |
Thiamine and Difficulties in Differentiating Type A From B Lactic Acidosis.
Topics: Acidosis, Lactic; Humans; Lactic Acid; Shock, Septic; Thiamine; Thiamine Deficiency | 2019 |
Gap acidosis except lactic acidosis develops and progresses during chronic kidney disease stage G5.
Topics: Acid-Base Equilibrium; Acidosis; Acidosis, Lactic; Aged; Aged, 80 and over; Biomarkers; Disease Prog | 2019 |
Chronic Ethanol Exposure Disrupts Lactate and Glucose Homeostasis and Induces Dysfunction of the Astrocyte-Neuron Lactate Shuttle in the Brain.
Topics: Acidosis, Lactic; Animals; Astrocytes; Central Nervous System Depressants; Ethanol; Glucose; Hippoca | 2019 |
Metformin-Associated Lactic Acidosis Presenting Like Acute Mesenteric Ischemia.
Topics: Acidosis, Lactic; Creatinine; Diabetes Mellitus, Type 2; Emergency Service, Hospital; Female; Humans | 2019 |
Follow-up of glycemic index before and after Ramadan fasting in type 2 diabetes patients under antidiabetic medications.
Topics: Acidosis, Lactic; Adult; Aged; Blood Glucose; Creatinine; Diabetes Mellitus, Type 2; Fasting; Female | 2019 |
Experimentally induced hyperchloremic and DL-lactic acidosis in calves: an attempt to study the effects of oral rehydration on acid-base status.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Animals; Animals, Newborn; Calcium; Carbon Dioxide; Cattle; | 2013 |
The Role of Metformin in Metformin-Associated Lactic Acidosis (MALA): Case Series and Formulation of a Model of Pathogenesis.
Topics: Acidosis, Lactic; Aged; Creatinine; Female; Humans; Hydrogen-Ion Concentration; Lactic Acid; Male; M | 2013 |
Formerly obese, now thin and confused: the utility of mnemonics in the approach to altered mental status.
Topics: Acidosis, Lactic; Adult; Bariatric Surgery; Confusion; Diagnosis, Differential; Female; Humans; Inte | 2013 |
Long-term safety of dichloroacetate in congenital lactic acidosis.
Topics: Acidosis, Lactic; Adolescent; Adult; Child; Child, Preschool; Dichloroacetic Acid; Female; Humans; L | 2013 |
Long-term safety of dichloroacetate in congenital lactic acidosis.
Topics: Acidosis, Lactic; Adolescent; Adult; Child; Child, Preschool; Dichloroacetic Acid; Female; Humans; L | 2013 |
Long-term safety of dichloroacetate in congenital lactic acidosis.
Topics: Acidosis, Lactic; Adolescent; Adult; Child; Child, Preschool; Dichloroacetic Acid; Female; Humans; L | 2013 |
Long-term safety of dichloroacetate in congenital lactic acidosis.
Topics: Acidosis, Lactic; Adolescent; Adult; Child; Child, Preschool; Dichloroacetic Acid; Female; Humans; L | 2013 |
Dysfunction of membrane-receptor system of blood cells and kidney tissue in experimental diabetes mellitus.
Topics: Acidosis, Lactic; Adenosine Triphosphate; Animals; Blood Glucose; Cell Membrane; Diabetes Mellitus, | 2013 |
Case records of the Massachusetts General Hospital. Case 23-2013. A 54-year-old woman with abdominal pain, vomiting, and confusion.
Topics: Abdominal Pain; Acidosis, Lactic; Confusion; Diabetes Mellitus, Type 2; Diagnosis, Differential; Fem | 2013 |
A patient with congenital hyperlactataemia and Leigh syndrome: an uncommon mitochondrial variant.
Topics: Acidosis, Lactic; DNA, Mitochondrial; Female; Humans; Infant; Lactic Acid; Leigh Disease; Pyruvic Ac | 2013 |
Longitudinal lactate levels from routine point-of-care monitoring in adult Malawian antiretroviral therapy patients: associations with stavudine toxicities.
Topics: Acidosis, Lactic; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cohort Studies; Dru | 2013 |
The relationship between lactate and thiamine levels in patients with diabetic ketoacidosis.
Topics: Acidosis, Lactic; Adult; Comorbidity; Diabetic Ketoacidosis; Female; Humans; Lactic Acid; Male; Midd | 2014 |
Acidosis drives damage-associated molecular pattern (DAMP)-induced interleukin-1 secretion via a caspase-1-independent pathway.
Topics: Acidosis, Lactic; Animals; Carrier Proteins; Caspase 1; Cathepsin D; Cell Line, Tumor; Humans; Hydro | 2013 |
Pyruvate Ringer's solution corrects lactic acidosis and prolongs survival during hemorrhagic shock in rats.
Topics: Acidosis, Lactic; Analysis of Variance; Animals; Arterial Pressure; Carbon Dioxide; Disease Models, | 2013 |
An in vitro model of the horse gut microbiome enables identification of lactate-utilizing bacteria that differentially respond to starch induction.
Topics: Acetic Acid; Acidosis, Lactic; Animal Feed; Animals; Bacterial Load; Cecum; Colon; Feces; Horses; Hy | 2013 |
Rate of increase in serum lactate level risk-stratifies infants after surgery for congenital heart disease.
Topics: Acidosis, Lactic; Age Factors; Area Under Curve; Biomarkers; Cardiac Surgical Procedures; Cardiopulm | 2014 |
Case 23-2013: a 54-year-old woman with metformin toxicity.
Topics: Acidosis, Lactic; Female; Humans; Lactic Acid; Metformin | 2013 |
Case 23-2013: a 54-year-old woman with metformin toxicity.
Topics: Acidosis, Lactic; Female; Humans; Lactic Acid; Metformin | 2013 |
Case 23-2013: a 54-year-old woman with metformin toxicity.
Topics: Acidosis, Lactic; Female; Humans; Lactic Acid; Metformin | 2013 |
Case 23-2013: a 54-year-old woman with metformin toxicity.
Topics: Acidosis, Lactic; Female; Humans; Lactic Acid; Metformin | 2013 |
Case 23-2013: a 54-year-old woman with metformin toxicity.
Topics: Acidosis, Lactic; Female; Humans; Lactic Acid; Metformin | 2013 |
Microcirculatory perfusion shift in the gut wall layers induced by extracorporeal circulation.
Topics: Acidosis, Lactic; Animals; Aorta, Thoracic; Blood Flow Velocity; Constriction; Extracorporeal Circul | 2015 |
Metformin accumulation: lactic acidosis and high plasmatic metformin levels in a retrospective case series of 66 patients on chronic therapy.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Chronic Disease; Creatinine; | 2014 |
Tighter precision target required for lactate testing in patients with lactic acidosis.
Topics: Acidosis, Lactic; Blood Chemical Analysis; Humans; Intensive Care Units; Lactic Acid; Reference Valu | 2014 |
Metformin accumulation without hyperlactataemia and metformin-induced hyperlactataemia without metformin accumulation.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Hypersensitivi | 2014 |
Salmeterol and lactic acidosis: clinical and educational aspects.
Topics: Acidosis, Lactic; Albuterol; Androstadienes; Asthma; Drug Overdose; Female; Humans; Intention; Lacti | 2014 |
Cerebral metabolic abnormalities in A3243G mitochondrial DNA mutation carriers.
Topics: Acidosis, Lactic; Adult; Aged; Aspartic Acid; Cerebral Cortex; Choline; Creatine; DNA, Mitochondrial | 2014 |
Metformin in peritoneal dialysis: a pilot experience.
Topics: Acidosis, Lactic; Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin | 2014 |
Severe lactic acidosis in critically ill patients with acute kidney injury treated with renal replacement therapy.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Aged; APACHE; Cohort Studies; Critical Care; Critical | 2014 |
Hyperlactemia induction modes affect the lactate minimum power and physiological responses in cycling.
Topics: Acidosis, Lactic; Adult; Bicarbonates; Bicycling; Exercise Test; Humans; Hydrogen-Ion Concentration; | 2014 |
[Effect of a new derivative of glutamic and apovincaminic acids on brain metabolism in post-ischemic period].
Topics: Acidosis, Lactic; Animals; Blood Glucose; Brain; Brain Ischemia; Cats; Glutamic Acid; Glycine; Lacti | 2014 |
Beyond Warburg effect--dual metabolic nature of cancer cells.
Topics: Acidosis, Lactic; Animals; Biological Transport; Cell Line, Tumor; Cell Proliferation; Disease Model | 2014 |
Risk of lactic acidosis or elevated lactate concentrations in metformin users with renal impairment: a population-based cohort study.
Topics: Acidosis, Lactic; Adult; Aged; Cohort Studies; Comorbidity; Diabetes Mellitus, Type 2; Female; Human | 2014 |
[Toxicological analysis is mandatory to interpret elevation in blood lactate concentration in toxic alcohol poisoning].
Topics: Acidosis, Lactic; Antidotes; Ethylene Glycol; Fomepizole; Humans; Lactic Acid; Pyrazoles | 2014 |
Severe lactic acidosis and multiorgan failure due to thiamine deficiency during total parenteral nutrition.
Topics: Acidosis, Lactic; Adolescent; Diagnosis, Differential; Humans; Hydrogen-Ion Concentration; Lactic Ac | 2014 |
A patient with acute liver failure and extreme hypoglycaemia with lactic acidosis who was not in a coma: causes and consequences of lactate-protected hypoglycaemia.
Topics: Acetaminophen; Acidosis, Lactic; Analgesics, Non-Narcotic; Blood Glucose; Follow-Up Studies; Humans; | 2014 |
Metabolic acidosis in the first 14 days of life in infants of gestation less than 26 weeks.
Topics: Acidosis, Lactic; Dopamine; Female; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Lac | 2015 |
Pharmacist review prevents evolving metformin-associated lactic acidosis.
Topics: Acidosis, Lactic; Aged; Community Pharmacy Services; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2014 |
Response to Dr Verd correspondence.
Topics: Acidosis, Lactic; Female; Humans; Infant, Premature; Lactic Acid; Male | 2015 |
Acid-base equilibrium in premature infants: don't forget feeding type.
Topics: Acidosis, Lactic; Female; Humans; Infant, Premature; Lactic Acid; Male | 2015 |
Lactic acidosis treatment by nanomole level of spermidine in an animal model.
Topics: Acidosis, Lactic; Animals; Disease Models, Animal; Hydrogen-Ion Concentration; Lactic Acid; Male; Ra | 2014 |
Fructose-1,6-diphosphatase deficiency: a treatable neurometabolic disorder.
Topics: Acidosis, Lactic; Child, Preschool; Female; Fructose-1,6-Diphosphatase Deficiency; Humans; Hypoglyce | 2014 |
Intermittent Cold-Blood Cardioplegia and Its Impact on Myocardial Acidosis during Coronary Bypass Surgery.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Biomarkers; Coronary Artery Bypass; Elective Surgical Pro | 2015 |
Lactic acidosis after cardiac transplantation: foe or common innocent bystander?
Topics: Acidosis, Lactic; Adult; Assisted Circulation; Cardiotonic Agents; Female; Graft Survival; Heart Tra | 2015 |
[Effects of ß-alanine supplementation on wingate tests in university female footballers].
Topics: Acidosis, Lactic; beta-Alanine; Dietary Supplements; Ergometry; Female; Humans; Lactic Acid; Soccer; | 2014 |
Reduced cerebral monocarboxylate transporters and lactate levels by ethanol and normobaric oxygen therapy in severe transient and permanent ischemic stroke.
Topics: Acidosis, Lactic; Animals; Brain; Brain Ischemia; Combined Modality Therapy; Disease Models, Animal; | 2015 |
A 3-year-old boy with ataxia.
Topics: Acidosis, Lactic; Ataxia; Child, Preschool; Diagnosis, Differential; Humans; Lactic Acid; Male; Shor | 2015 |
Lactic acidosis.
Topics: Acidosis, Lactic; Humans; Lactic Acid | 2015 |
Lactic acidosis.
Topics: Acidosis, Lactic; Humans; Lactic Acid | 2015 |
Lactic acidosis.
Topics: Acidosis, Lactic; Humans; Lactic Acid | 2015 |
Lactic acidosis.
Topics: Acidosis, Lactic; Humans; Lactic Acid | 2015 |
Lactic acidosis.
Topics: Acidosis, Lactic; Humans; Lactic Acid | 2015 |
Lactic acidosis.
Topics: Acidosis, Lactic; Humans; Lactic Acid | 2015 |
Intrauterine Growth Restricted Rats Exercised at Pregnancy: Maternal-Fetal Repercussions.
Topics: Acidosis, Lactic; Animals; Biomarkers; Birth Weight; Blood Glucose; Diabetes Mellitus, Experimental; | 2015 |
Peripheral venous lactate at admission is associated with in-hospital mortality, a prospective cohort study.
Topics: Acidosis, Lactic; Adolescent; Adult; Aged; Aged, 80 and over; Cohort Studies; Female; Hospital Morta | 2015 |
Impact of Japanese regulatory action on metformin-associated lactic acidosis in type II diabetes patients.
Topics: Acidosis, Lactic; Adult; Aged; Cohort Studies; Data Collection; Databases, Factual; Diabetes Mellitu | 2015 |
[Metformin-induced lactic acidosis : Severe symptoms with difficult diagnostics].
Topics: Acidosis, Lactic; Acute Kidney Injury; Carbon Dioxide; Diabetes Mellitus, Type 2; Epinephrine; Human | 2015 |
Safety of metformin in patients with chronic obstructive pulmonary disease and type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Biomarkers; Diabetes Mellitus, Type 2; Female; Hum | 2015 |
Does lactate account for all of the increase in anion gap in cases of metformin-induced lactic acidosis?
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Shock, | 2015 |
Hextend-perfluorocarbon cocktail inhibits mean arterial pressure response in a rabbit shock model.
Topics: Acidosis, Lactic; Animals; Blood Pressure; Blood Substitutes; Disease Models, Animal; Drug Evaluatio | 2015 |
Prognostic role of lactate on mortality in younger and older patients with cardio-respiratory failure admitted to an acute intensive care unit.
Topics: Acidosis, Lactic; Acute Coronary Syndrome; Aged; Female; Hospital Mortality; Hospitalization; Humans | 2016 |
Mitochondrial Respiratory Defect Causes Dysfunctional Lactate Turnover via AMP-activated Protein Kinase Activation in Human-induced Pluripotent Stem Cell-derived Hepatocytes.
Topics: Acidosis, Lactic; AMP-Activated Protein Kinases; Cell Differentiation; DNA, Mitochondrial; Electron | 2015 |
Fecal Transplantation Successfully Treats Recurrent D-Lactic Acidosis in a Child With Short Bowel Syndrome.
Topics: Acidosis, Lactic; Adolescent; Fecal Microbiota Transplantation; Feces; Humans; Intestinal Mucosa; In | 2017 |
Lactic acidosis: relationship between metformin levels, lactate concentration and mortality.
Topics: Acidosis, Lactic; Adolescent; Adult; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Female; Hum | 2016 |
Umbilical Cord Venous Lactate for Predicting Arterial Lactic Acidemia and Neonatal Morbidity at Term.
Topics: Acidosis, Lactic; Adult; Female; Fetal Blood; Humans; Infant, Newborn; Lactic Acid; Predictive Value | 2016 |
Cost effectiveness of universal umbilical cord blood gas and lactate analysis in a tertiary level maternity unit.
Topics: Acidosis, Lactic; Adult; Blood Gas Analysis; Cost-Benefit Analysis; Decision Trees; Female; Fetal Bl | 2016 |
Lactic Acidosis in Diabetic Population: Is Metformin Implicated? Results of a Matched Case-Control Study Performed on the Type 2 Diabetes Population of Grenoble Hospital University.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Di | 2016 |
Massive acetaminophen overdose: effect of hemodialysis on acetaminophen and acetylcysteine kinetics.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Adolescent; Coma; Drug Overdose; Emergency Service, | 2016 |
Skeletal muscle lactate overproduction during metformin intoxication: An animal study with reverse microdialysis.
Topics: Acidosis, Lactic; Animals; Glycolysis; Hypoglycemic Agents; Infusions, Parenteral; Lactic Acid; Metf | 2016 |
Metformin-Associated Lactic Acidosis in a Patient with Normal Renal Function.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Female; Humans; Kidney Function Tests; Lactic Aci | 2016 |
Lactic acidosis switches cancer cells from aerobic glycolysis back to dominant oxidative phosphorylation.
Topics: Acidosis, Lactic; Adenosine Triphosphate; Aerobiosis; Cell Line, Tumor; Glucose; Glycolysis; HeLa Ce | 2016 |
Intraoperative acidosis is a new predictor for postoperative pancreatic fistula after pancreaticoduodenectomy.
Topics: Acidosis, Lactic; Aged; Amylases; Area Under Curve; Biomarkers; Early Diagnosis; Erythrocyte Indices | 2016 |
Umbilical Cord Venous Lactate for Predicting Arterial Lactic Acidemia and Neonatal Morbidity at Term.
Topics: Acidosis, Lactic; Fetal Blood; Humans; Hydrogen-Ion Concentration; Lactic Acid; Term Birth; Umbilica | 2016 |
Umbilical Cord Venous Lactate for Predicting Arterial Lactic Acidemia and Neonatal Morbidity at Term.
Topics: Acidosis, Lactic; Fetal Blood; Humans; Hydrogen-Ion Concentration; Lactic Acid; Term Birth; Umbilica | 2016 |
Diagnostic accuracy of fetal scalp lactate for intrapartum acidosis compared with scalp pH.
Topics: Acidosis, Lactic; Adult; Cohort Studies; False Positive Reactions; Female; Fetal Blood; Fetal Monito | 2017 |
Prognosis of alcohol-associated lactic acidosis in critically ill patients: an 8-year study.
Topics: Acidosis, Lactic; Adult; Aged; Alcoholism; Critical Care; Critical Illness; Female; Hospital Mortali | 2016 |
An improved amperometric L-lactate biosensor based on covalent immobilization of microbial lactate oxidase onto carboxylated multiwalled carbon nanotubes/copper nanoparticles/polyaniline modified pencil graphite electrode.
Topics: Acidosis, Lactic; Aniline Compounds; Bacterial Proteins; Biosensing Techniques; Blood Chemical Analy | 2017 |
Uncovering molecular abnormalities leading to the Warburg effect in primary refractory diffuse large B-cell lymphoma.
Topics: Acidosis, Lactic; Aged; Antineoplastic Combined Chemotherapy Protocols; Chromosome Aberrations; Drug | 2016 |
Association between Metformin Use and Risk of Lactic Acidosis or Elevated Lactate Concentration in Type 2 Diabetes.
Topics: Acidosis, Lactic; Adult; Aged; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; H | 2017 |
White sturgeon (Acipenser transmontanus) acid-base regulation differs in response to different types of acidoses.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Acidosis, Respiratory; Animals; Brain; Carbon Dioxide; Chlo | 2017 |
Validation of the Accutrend lactate meter for hyperlactatemia screening during antiretroviral therapy in a resource-poor setting.
Topics: Acidosis, Lactic; Cross-Sectional Studies; Humans; Lactic Acid; Point-of-Care Systems; Predictive Va | 2008 |
[Levels of lactic acid].
Topics: Acidosis, Lactic; Arteries; Blood Specimen Collection; Causality; Drug Interactions; Humans; Hypoxia | 2008 |
Co-factors for abnormal lactate levels among persons with HIV disease at a tertiary HIV care setting in South India.
Topics: Acidosis, Lactic; Adult; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Cross-Sectiona | 2008 |
A preliminary study of thiamine status in northeastern Thai children with acute diarrhea.
Topics: Acidosis, Lactic; Acute Disease; Case-Control Studies; Child; Child, Preschool; Diarrhea; Female; Hu | 2007 |
Counterpoint: Lactic acid is not the only physicochemical contributor to the acidosis of exercise.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Animals; Chemical Phenomena; Chemistry, Physical; Erythrocy | 2008 |
Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro.
Topics: Acidosis, Lactic; Animals; Blood Glucose; Buformin; Cell Line; Cell Respiration; Cell Survival; Cult | 2008 |
Increased brain lactate during stroke-like episode in a patient with congenital disorder of glycosylation type Ia.
Topics: Acidosis, Lactic; Aspartic Acid; Brain; Carbohydrate Metabolism, Inborn Errors; Child; Female; Fever | 2009 |
Lactic acidosis not hyperlactatemia as a predictor of in hospital mortality in septic emergency patients.
Topics: Acidosis, Lactic; Emergency Service, Hospital; Epidemiologic Methods; Female; Hospital Mortality; Hu | 2008 |
False elevation of blood lactate reveals ethylene glycol poisoning.
Topics: Acidosis, Lactic; Alcohols; Blood Gas Analysis; Ethylene Glycol; Humans; Lactic Acid; Male; Middle A | 2009 |
[Clinical implications of lactic acidosis in purulent meningitis].
Topics: Acidosis, Lactic; Adolescent; Adult; Aged; Female; Humans; Lactic Acid; Male; Meningitis, Meningococ | 2008 |
Anion gap, anion gap corrected for albumin, base deficit and unmeasured anions in critically ill patients: implications on the assessment of metabolic acidosis and the diagnosis of hyperlactatemia.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Adult; Aged; Albumins; Anions; Blood Chemical Analysis; Coh | 2008 |
Symptomatic hyperlactataemia in adults on antiretroviral therapy: a single-centre experience.
Topics: Acidosis, Lactic; Adult; Aged; Anti-Retroviral Agents; Cohort Studies; Female; HIV Infections; Human | 2008 |
Pyruvate dehydrogenase phosphatase 1 (PDP1) null mutation produces a lethal infantile phenotype.
Topics: Acidosis, Lactic; Animals; Base Sequence; Brain; Cells, Cultured; Codon, Nonsense; Consanguinity; DN | 2009 |
Augmented serum lactic acid combined with metabolic alkalosis: a case report.
Topics: Acidosis, Lactic; Fatal Outcome; Female; Fluid Therapy; Humans; Hydrogen-Ion Concentration; Lactic A | 2008 |
Cariporide (HOE642) attenuates lactic acidosis induced pulmonary vein arrhythmogenesis.
Topics: Acidosis, Lactic; Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electric | 2009 |
Prolonged propofol anesthesia is not associated with an increase in blood lactate.
Topics: Acidosis, Lactic; Adult; Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Drug Administratio | 2009 |
Cardiac autonomic responses to repeated shuttle sprints.
Topics: Acidosis, Lactic; Adult; Autonomic Nervous System; Exercise Test; Heart Rate; Humans; Lactic Acid; M | 2009 |
Risk factors for and clinical characteristics of severe hyperlactataemia in patients receiving antiretroviral therapy: a case-control study.
Topics: Acidosis, Lactic; Adult; Alanine Transaminase; Anti-HIV Agents; Developing Countries; Drug Administr | 2010 |
Lactate: finally ready for prime time?
Topics: Acidosis, Lactic; Critical Care; Decision Support Techniques; Humans; Lactic Acid; Monitoring, Physi | 2009 |
Metformin use in renal dysfunction: is a serum creatinine threshold appropriate?
Topics: Acidosis, Lactic; Creatinine; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Kidney Disease | 2009 |
Loading of trained inspiratory muscles speeds lactate recovery kinetics.
Topics: Acidosis, Lactic; Bicycling; Blood Gas Analysis; Breathing Exercises; Case-Control Studies; Exercise | 2010 |
Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes.
Topics: Acidosis, Lactic; Cell Line, Tumor; Cell Survival; Cells, Cultured; Coculture Techniques; Energy Met | 2010 |
A case of human poisoning with a flufenoxuron-containing insecticide.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Aged; Bicarbonates; Cardiac Output; Female; Humans; Insecti | 2010 |
D-lactic acidosis and ataxia in a man with Crohn disease.
Topics: Acidosis, Lactic; Anti-Inflammatory Agents; Antidiarrheals; Ataxia; Crohn Disease; Diagnosis, Differ | 2010 |
Lactic acidosis in vivo: testing the link between lactate generation and H+ accumulation in ischemic mouse muscle.
Topics: Acidosis, Lactic; Animals; Female; Hydrogen-Ion Concentration; Ischemia; Lactic Acid; Mice; Muscle, | 2010 |
Diaspirin cross-linked hemoglobin infusion did not influence base deficit and lactic acid levels in two clinical trials of traumatic hemorrhagic shock patient resuscitation.
Topics: Acidosis, Lactic; Adult; Aspirin; Emergency Medical Services; Emergency Treatment; Europe; Fluid The | 2010 |
What does glycolysis make and why is it important?
Topics: Acidosis, Lactic; Animals; Female; Glycolysis; Hydrogen-Ion Concentration; Ischemia; Lactic Acid; Mi | 2010 |
Hyperlactatemia in neonates admitted to the cardiac intensive care unit with critical heart disease.
Topics: Acidosis, Lactic; Acute Disease; Heart Defects, Congenital; Humans; Infant, Newborn; Intensive Care | 2010 |
Lactic acid levels in patients with chronic obstructive pulmonary disease accomplishing unsupported arm exercises.
Topics: Acidosis, Lactic; Aged; Arm; Blood Pressure; Exercise; Exercise Test; Exercise Tolerance; Female; Fo | 2010 |
When the skin gives the alarm.
Topics: Acidosis, Lactic; Aged; Blood Pressure; Dehydration; Humans; Lactic Acid; Livedo Reticularis; Male | 2010 |
Postexercise heart rate recovery in children: relationship with power output, blood pH, and lactate.
Topics: Acidosis, Lactic; Adolescent; Age Factors; Aging; Bicycling; Biomarkers; Child; Exercise; Glycolysis | 2010 |
Hyperlactic acidosis as metabolic side-effect of albuterol and theophylline in acute severe asthma.
Topics: Acidosis, Lactic; Administration, Inhalation; Adolescent; Albuterol; Anti-Asthmatic Agents; Anti-Inf | 2010 |
Comparison of potential risks of lactic acidosis induction by biguanides in rats.
Topics: Acidosis, Lactic; Animals; Dose-Response Relationship, Drug; Female; Hypoglycemic Agents; Lactic Aci | 2010 |
The cardiovascular, respiratory, and metabolic effects of a long duration electronic control device exposure in human volunteers.
Topics: Acidosis, Lactic; Adult; Biomarkers; Cardiovascular Diseases; Conducted Energy Weapon Injuries; Crea | 2010 |
Lactic acidemia in the pathogenesis of mice carrying mitochondrial DNA with a deletion.
Topics: Acidosis, Lactic; Animals; Behavior, Animal; Cell Respiration; Dichloroacetic Acid; Disease Models, | 2010 |
Preoperative acidosis and infant development following surgery for congenital heart disease.
Topics: Acidosis, Lactic; Cardiopulmonary Bypass; Cohort Studies; Developmental Disabilities; Heart Arrest, | 2010 |
Dihydrolipoamide dehydrogenase (DLD) deficiency in a Spanish patient with myopathic presentation due to a new mutation in the interface domain.
Topics: Acidosis, Lactic; Adult; Amino Acid Sequence; Base Sequence; Biomarkers; Blepharoptosis; Cells, Cult | 2010 |
Changes in blood constituents of swine transported for 8 or 16 h to an Abattoir.
Topics: Abattoirs; Acidosis, Lactic; Animals; Blood Glucose; Body Temperature; Calcium; Dehydration; Female; | 2010 |
Falsely elevated lactate in severe ethylene glycol intoxication.
Topics: Acidosis, Lactic; Adult; Blood Gas Analysis; Diagnosis, Differential; Ethanol; Ethylene Glycol; Fals | 2010 |
Early anion gap metabolic acidosis in acetaminophen overdose.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis, Lactic; Adult; Analgesics, Non-Narcotic; Analysis of | 2010 |
Increased plasma d-lactic acid associated with impaired memory in rats.
Topics: Acidosis, Lactic; Analysis of Variance; Animals; Diet; Fermentation; Lactic Acid; Male; Memory Disor | 2010 |
Diabetes, metformin and lactic acidosis.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus; Female; Humans; Lactic Acid; Male; Metformin; Middle Aged | 2011 |
Persistent sepsis-induced hypotension without hyperlactatemia: is it really septic shock?
Topics: Acidosis, Lactic; Algorithms; APACHE; Biomarkers; Chi-Square Distribution; Female; Humans; Hypertens | 2011 |
Persistent sepsis-induced hypotension without hyperlactatemia: is it really septic shock?
Topics: Acidosis, Lactic; Algorithms; APACHE; Biomarkers; Chi-Square Distribution; Female; Humans; Hypertens | 2011 |
Persistent sepsis-induced hypotension without hyperlactatemia: is it really septic shock?
Topics: Acidosis, Lactic; Algorithms; APACHE; Biomarkers; Chi-Square Distribution; Female; Humans; Hypertens | 2011 |
Persistent sepsis-induced hypotension without hyperlactatemia: is it really septic shock?
Topics: Acidosis, Lactic; Algorithms; APACHE; Biomarkers; Chi-Square Distribution; Female; Humans; Hypertens | 2011 |
Evaluation of mitochondrial toxicity in Marmota himalayana treated with metacavir, a novel 2',3'-dideoxyguanosine prodrug for treatment of hepatitis B Virus.
Topics: Acidosis, Lactic; Animals; Antiviral Agents; Dideoxynucleosides; DNA, Mitochondrial; Fatty Liver; He | 2011 |
An extreme and life-threatening case of recurrent D-lactate encephalopathy.
Topics: Acidosis, Lactic; Brain Diseases; Humans; Kidney Failure, Chronic; Lactic Acid; Male; Middle Aged; R | 2011 |
[Peptide-bound oxyproline content in patients with nail hyperkeratosis and lactic acidosis].
Topics: Acidosis, Lactic; Female; Humans; Hydroxyproline; Hyperkeratosis, Epidermolytic; Lactic Acid; Male; | 2011 |
Dialysis therapy for lactic acidosis caused by metformin intoxication: presentation of two cases.
Topics: Acidosis, Lactic; Adolescent; Bicarbonates; Diabetes Mellitus, Type 2; Dialysis Solutions; Humans; H | 2011 |
Risk factors for fatality in HIV-infected patients with dideoxynucleoside-induced severe hyperlactataemia or lactic acidosis.
Topics: Acidosis, Lactic; Adult; Anti-HIV Agents; Dideoxynucleosides; Female; HIV Infections; HIV-1; Humans; | 2011 |
Mechanism of lactic acidosis in children with acute severe asthma.
Topics: Acidosis, Lactic; Adolescent; Blood Gas Analysis; Bronchodilator Agents; Child; Child, Preschool; Co | 2012 |
A risk-factor guided approach to reducing lactic acidosis and hyperlactatemia in patients on antiretroviral therapy.
Topics: Acidosis, Lactic; Adult; Antiretroviral Therapy, Highly Active; Body Mass Index; Cell Death; Cohort | 2011 |
Metformin associated lactic acidosis: incidence and clinical correlation with metformin serum concentration measurements.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Early | 2011 |
Comments on Point:Counterpoint: Muscle lactate and H⁺ production do/do not have a 1:1 association in skeletal muscle. Lactate and acidosis yet again?
Topics: Acidosis, Lactic; Anaerobic Threshold; Animals; Humans; Lactic Acid; Models, Biological; Muscle Cont | 2011 |
Comments on Point:Counterpoint: Muscle lactate and H⁺ production do/do not have a 1:1 association in skeletal muscle. Lactate and acidosis yet again?
Topics: Acidosis, Lactic; Anaerobic Threshold; Animals; Humans; Lactic Acid; Models, Biological; Muscle Cont | 2011 |
Comments on Point:Counterpoint: Muscle lactate and H⁺ production do/do not have a 1:1 association in skeletal muscle. Lactate and acidosis yet again?
Topics: Acidosis, Lactic; Anaerobic Threshold; Animals; Humans; Lactic Acid; Models, Biological; Muscle Cont | 2011 |
Take my breath away: a case of lactic acidosis in an asthma exacerbation.
Topics: Acidosis, Lactic; Adult; Asthma; Diagnosis, Differential; Electrocardiography; Humans; Lactic Acid; | 2011 |
D-lactic acid interferes with the effects of platelet activating factor on bovine neutrophils.
Topics: Acidosis, Lactic; Animals; Calcium; Cattle; Cattle Diseases; CD11b Antigen; Female; Flow Cytometry; | 2011 |
Linezolid and lactic acidosis: a role for lactate monitoring with long-term linezolid use in children.
Topics: Acetamides; Acidosis, Lactic; Adolescent; Anti-Bacterial Agents; Fatal Outcome; Female; Humans; Infa | 2011 |
Unilateral periventricular leukomalacia in association with pyruvate dehydrogenase deficiency.
Topics: Acidosis, Lactic; Alleles; Cerebral Ventricles; Developmental Disabilities; Diagnosis, Differential; | 2012 |
Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation.
Topics: Acidosis, Lactic; Cell Line, Tumor; Cytotoxicity, Immunologic; Humans; Hydrogen-Ion Concentration; I | 2012 |
Metformin-associated lactic acidosis following acute kidney injury. Efficacious treatment with continuous renal replacement therapy.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Biomarkers; Creatinine; Female; Huma | 2012 |
Discrepancy between heart rate and makers of hypoperfusion is a predictor of mortality in trauma patients.
Topics: Acidosis, Lactic; Adult; Blood Pressure; Heart Rate; Humans; Injury Severity Score; Lactic Acid; Log | 2011 |
Hyperlactatemia and in utero exposure to antiretrovirals: is the control group the clue?
Topics: Acidosis, Lactic; Adult; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Cohort Studi | 2012 |
Metformin intoxication requiring dialysis.
Topics: Acidosis, Lactic; Diabetes Mellitus; Female; Humans; Lactic Acid; Male; Metformin; Middle Aged; Rena | 2011 |
Impact of peripherally established cardiopulmonary bypass on regional and systemic blood lactate levels.
Topics: Acidosis, Lactic; Adolescent; Adult; Carbon Dioxide; Cardiopulmonary Bypass; Child; Child, Preschool | 2012 |
Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis.
Topics: Acidosis, Lactic; Animals; Diabetes Mellitus; Dose-Response Relationship, Drug; HEK293 Cells; Homozy | 2012 |
Metformin therapy in patients with chronic kidney disease.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Dose-Response Relationship, Dr | 2012 |
An energy-failure based brain edema concept.
Topics: Acidosis, Lactic; Animals; Brain Edema; Energy Metabolism; Glucose; Humans; Lactic Acid; Models, Neu | 2012 |
The role of nucleoside reverse transcriptase inhibitors usage in the incidence of hyperlactatemia and lactic acidosis in HIV/AIDS patients.
Topics: Acidosis, Lactic; Acquired Immunodeficiency Syndrome; Adult; CD4 Lymphocyte Count; Didanosine; Drug | 2012 |
The association of promoter gene polymorphisms of the tumor necrosis factor-α and interleukin-10 with severity of lactic acidosis during liver transplantation surgery.
Topics: Acidosis, Lactic; Adult; Biomarkers; Egypt; Female; Genetic Predisposition to Disease; Heterozygote; | 2012 |
[Type B lactic acidosis associated with marginal lymphoma of the spleen: report of one case].
Topics: Acidosis, Lactic; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Diagnosis, Di | 2012 |
The level of lactic acidosis affects lactate minimum in a heart rate-based lactate minimum test.
Topics: Acidosis, Lactic; Adult; Athletic Performance; Bicycling; Exercise Test; Heart Rate; Humans; Lactic | 2012 |
Sodium bicarbonate treatment during transient or sustained lactic acidemia in normoxic and normotensive rats.
Topics: Acidosis, Lactic; Animals; Hemodynamics; Hydrogen-Ion Concentration; Lactic Acid; Phosphofructokinas | 2012 |
"Hyper-warburgism," a cause of asymptomatic hypoglycemia with lactic acidosis in a patient with non-Hodgkin's lymphoma.
Topics: Acidosis, Lactic; Asymptomatic Diseases; Female; Glucose; Glycolysis; Humans; Hypoglycemia; Lactic A | 2012 |
Incidence and significance of elevated lactate in the identification of critically ill patients.
Topics: Acidosis, Lactic; Adult; Critical Illness; Emergency Medical Services; Female; Humans; Intensive Car | 2012 |
Lactic acidosis following intentional overdose by inhalation of salmeterol and fluticasone.
Topics: Acidosis, Lactic; Administration, Inhalation; Adolescent; Adrenergic beta-2 Receptor Agonists; Albut | 2012 |
Salbutamol usage and lactic acidosis in acute severe asthma.
Topics: Acidosis, Lactic; Female; Humans; Intensive Care Units, Pediatric; Lactic Acid; Male; Status Asthmat | 2013 |
The author replies.
Topics: Acidosis, Lactic; Female; Humans; Intensive Care Units, Pediatric; Lactic Acid; Male; Status Asthmat | 2013 |
Lactate to creatinine ratio in amniotic fluid: a pilot study.
Topics: Acidosis, Lactic; Amniotic Fluid; Biomarkers; Cesarean Section; Creatinine; Female; Fetal Blood; Fet | 2013 |
Hyperlactatemia and concurrent use of antiretroviral therapy among HIV infected patients in Uganda.
Topics: Acidosis, Lactic; Adolescent; Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Cross-Sectional Studi | 2012 |
Hyperlactataemia and lactic acidosis during antiretroviral therapy: relevance, reproducibility and possible risk factors.
Topics: Acidosis, Lactic; Adult; Anti-HIV Agents; Cross-Sectional Studies; Didanosine; Dideoxynucleosides; F | 2002 |
Hyperlactatemia and lactic acidosis: should routine screening be considered?
Topics: Acidosis, Lactic; HIV Infections; Humans; Lactic Acid; Reverse Transcriptase Inhibitors | 2002 |
Increased long-term mitochondrial toxicity in combinations of nucleoside analogue reverse-transcriptase inhibitors.
Topics: Acidosis, Lactic; Cell Line; Chemical and Drug Induced Liver Injury; Cyclooxygenase 2; DNA, Mitochon | 2002 |
Evidence that acidosis alters the high-affinity dopamine uptake in rat striatal slices and synaptosomes by different mechanisms partially related to oxidative damage.
Topics: Acidosis; Acidosis, Lactic; Animals; Antioxidants; Chromans; Corpus Striatum; Culture Media; Dopamin | 2003 |
Lactic acidemia associated with metformin.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; L | 2003 |
Prevalence, risk factors and outcome of hyperlactataemia in HIV-infected patients.
Topics: Acidosis, Lactic; Adult; Anti-HIV Agents; Didanosine; Female; Follow-Up Studies; HIV Infections; Hum | 2003 |
Hyperlactataemia in HIV-infected patients: the role of NRTI-treatment.
Topics: Acidosis, Lactic; Adult; Anti-HIV Agents; Cross-Sectional Studies; Female; HIV Infections; Humans; L | 2002 |
Effects of epinephrine and norepinephrine on hemodynamics, oxidative metabolism, and organ energetics in endotoxemic rats.
Topics: Acidosis, Lactic; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Blood Gas Analysis; Diseas | 2003 |
D-lactic acidosis secondary to short bowel syndrome.
Topics: Acidosis, Lactic; Child; Humans; Lactic Acid; Male; Short Bowel Syndrome | 2003 |
Multiple myeloma associated with lactic acidosis.
Topics: Acidosis, Lactic; Disease Progression; Humans; Immunoglobulin G; Immunoglobulin kappa-Chains; Lactic | 2002 |
The hepatosplanchnic area is not a common source of lactate production.
Topics: Acidosis, Lactic; Acute Disease; Humans; Lactic Acid; Liver; Mesentery; Sepsis; Time Factors | 2003 |
Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin.
Topics: Acidosis, Lactic; Animals; Biguanides; Disease Models, Animal; DNA-Binding Proteins; Hepatocytes; Ho | 2003 |
Lactic acidemia in infection with human immunodeficiency virus.
Topics: Acidosis, Lactic; HIV; HIV Infections; Humans; Lactic Acid; Outcome Assessment, Health Care; Reverse | 2003 |
Lactic acidosis.
Topics: Acidosis, Lactic; Animals; Humans; Hydrogen-Ion Concentration; Lactic Acid; Prognosis | 2003 |
Reversible nucleoside analogue-associated lactic acidosis despite a prolonged course.
Topics: Acidosis, Lactic; Adult; Anti-HIV Agents; Bicarbonates; Female; Hemodiafiltration; HIV Reverse Trans | 2003 |
Blood glucose threshold and the metabolic responses to incremental exercise tests with and without prior lactic acidosis induction.
Topics: Acidosis, Lactic; Adult; Anaerobic Threshold; Blood Glucose; Energy Metabolism; Exercise Test; Heart | 2003 |
Human immunodeficiency virus infection with human granulocytic ehrlichiosis complicated by symptomatic lactic acidosis.
Topics: Acidosis, Lactic; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Ehrlichiosis; HIV Infectio | 2003 |
Frequency, risk factors, and outcome of hyperlactatemia in HIV-positive persons: implications for the management of treated patients.
Topics: Acidosis, Lactic; Adult; Anti-HIV Agents; Cross-Sectional Studies; Drug Therapy, Combination; Female | 2003 |
[Metformin-associated lactic acidosis precipitated by acute renal failure].
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Blood Gas Analysis; Diabetes Mellitus, Type 2; Female; | 2003 |
[Metformin-associated lactic acidosis remains a serious complication of metformin therapy].
Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Aged; Diabetes Complications; Diabetes Mellitus, Type | 2003 |
EMG signs of neuromuscular fatigue related to the ventilatory threshold during cycling exercise.
Topics: Acidosis, Lactic; Adult; Electromyography; Exercise Test; Female; Humans; Hydrogen-Ion Concentration | 2003 |
Lactate sequestration by osteoderms of the broad-nose caiman, Caiman latirostris, following capture and forced submergence.
Topics: Acidosis, Lactic; Alligators and Crocodiles; Analysis of Variance; Animals; Bone and Bones; Calcium; | 2003 |
Unmeasured anions in critically ill patients: can they predict mortality?
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Aged; APACHE; Bicarbonates; Blood Gas Analysis; Calcium; Ca | 2003 |
LACTIC ACID ACIDEMIA AND PHENFORMIN.
Topics: Acidosis; Acidosis, Lactic; Blood; Diabetes Mellitus; Diabetic Ketoacidosis; Humans; Lactates; Lacti | 1964 |
[STUDIES ON THE BIOCHEMISTRY AND CLINICAL ASPECTS OF LACTIC ACID ACIDOSIS].
Topics: Acidosis; Acidosis, Lactic; Blood Chemical Analysis; Humans; Lactates; Lactic Acid | 1964 |
THE CLINICAL SIGNIFICANCE OF ELEVATED BLOOD LACTATE.
Topics: Acidosis; Acidosis, Lactic; Blood; Chemical Phenomena; Chemistry; Geriatrics; Humans; Hypertension; | 1965 |
Complement activation during hemorrhagic shock and resuscitation in swine.
Topics: Acidosis, Lactic; Animals; Complement Activation; Complement C5a; Complement System Proteins; In Vit | 2003 |
Hyperlactatemia in human immunodeficiency virus-infected children receiving antiretroviral treatment.
Topics: Acidosis, Lactic; Adolescent; Age Distribution; Analysis of Variance; Anti-HIV Agents; Child; Child, | 2003 |
Lactic acidemia in human immunodeficiency virus-uninfected infants exposed to perinatal antiretroviral therapy.
Topics: Acidosis, Lactic; Adult; Antiretroviral Therapy, Highly Active; Case-Control Studies; Cohort Studies | 2003 |
Lactate as a modulator of hypoxia-induced hyperventilation.
Topics: Acidosis, Lactic; Animals; Dichloroacetic Acid; Enzyme Inhibitors; Hyperventilation; Hypoxia; Lactic | 2003 |
Matched case-control study to evaluate risk factors for hyperlactataemia in HIV patients on antiretroviral therapy.
Topics: Acidosis, Lactic; Anti-HIV Agents; Case-Control Studies; Didanosine; Female; HIV Infections; Humans; | 2003 |
Preanalytical handling of samples for measurement of plasma lactate in HIV patients.
Topics: Acidosis, Lactic; Adult; Blood Preservation; Glycolysis; HIV Infections; Humans; Hydrogen-Ion Concen | 2003 |
Lacticacidosis after short-term infusion of propofol for anaesthesia in a child with osteogenesis imperfecta.
Topics: Acidosis, Lactic; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Dose-Response Relationsh | 2003 |
Severe lactic acidosis due to thiamine deficiency in a patient with B-cell leukemia/lymphoma on total parenteral nutrition during high-dose methotrexate therapy.
Topics: Acidosis, Lactic; Female; Gas Chromatography-Mass Spectrometry; Humans; Infant; Lactic Acid; Leukemi | 2003 |
Respiratory complex II defect in siblings associated with a symptomatic secondary block in fatty acid oxidation.
Topics: Acidosis, Lactic; Acyl-CoA Dehydrogenase; Behavior; Bicarbonates; Carnitine; Cell Line; Fatty Acids; | 2003 |
Depletion of mitochondrial DNA in liver under antiretroviral therapy with didanosine, stavudine, or zalcitabine.
Topics: Acidosis, Lactic; Adult; Cross-Sectional Studies; Didanosine; DNA, Mitochondrial; Female; Hepatitis | 2004 |
Highly active antiretroviral therapy (HAART)-associated lactic acidosis: in vitro effects of combination of nucleoside analogues and protease inhibitors on mitochondrial function and lactic acid production.
Topics: Acidosis, Lactic; Adenosine Triphosphate; Antiretroviral Therapy, Highly Active; Cell Line, Tumor; D | 2003 |
Lactic acidosis progressively impairs dopamine uptake in rat striatal synaptosomes by a mechanism partially independent of the Na+/K+-ATPase dysfunction.
Topics: Acidosis, Lactic; Animals; Corpus Striatum; Dopamine; Lactic Acid; Male; Rats; Rats, Wistar; Sodium- | 2004 |
Dysfunctional labor and myometrial lactic acidosis.
Topics: Acidosis, Lactic; Blood Gas Analysis; Cesarean Section; Culture Techniques; Female; Humans; Lactic A | 2004 |
Gas exchange responses to constant work-rate exercise in patients with glycogenosis type V and VII.
Topics: Acidosis, Lactic; Adult; Case-Control Studies; Epinephrine; Exercise; Exercise Test; Exercise Tolera | 2004 |
Therapeutic effects of glucose infusion on monochloroacetic acid exposure in rats.
Topics: Acetates; Acidosis, Lactic; Animals; Blood Glucose; Glucose; Hypoglycemia; Infusions, Intravenous; L | 2002 |
[Lactic acidosis in HIV-patients--diagnosis and treatment].
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Anti-HIV Agents; DNA Polymerase gamma; DNA Replication; DNA | 2004 |
Too much lactate or too little liver?
Topics: Acidosis, Lactic; Adenosine Triphosphate; Aged; Female; Hemofiltration; Humans; Lactic Acid; Liver; | 2004 |
Investigations on the influence of serum D-lactate levels on clinical signs in calves with metabolic acidosis.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Animals; Animals, Suckling; Cattle; Cattle Diseases; Diarrh | 2004 |
Severe lactic acidosis following alcohol related generalised seizures.
Topics: Acidosis, Lactic; Alcoholism; Epilepsy, Tonic-Clonic; Humans; Lactic Acid; Male; Middle Aged | 2004 |
Influence of D-lactate on metabolic acidosis and on prognosis in neonatal calves with diarrhoea.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Animals; Animals, Newborn; Blood Gas Analysis; Cattle; Catt | 2004 |
Cerebral lactic acidosis correlates with neurological impairment in MELAS.
Topics: Acidosis, Lactic; Astrocytes; Biological Transport; Brain Damage, Chronic; Cerebral Ventricles; Huma | 2004 |
A response to 'Severe lactic acidosis following alcohol related generalised seizures'.
Topics: Acidosis, Lactic; Alcoholism; Epilepsy, Tonic-Clonic; Humans; Lactic Acid | 2005 |
Risk factors for hyperlactataemia in HIV-infected patients, Aquitaine Cohort, 1999--2003.
Topics: Acidosis, Lactic; Acquired Immunodeficiency Syndrome; Adult; Age Factors; Anti-HIV Agents; CD4 Antig | 2005 |
The strong ion gap predicts mortality in children following cardiopulmonary bypass surgery.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Cardiopulmonary Bypass; Child, Preschool; Heart Defects, Co | 2005 |
Propofol infusion syndrome associated with short-term large-dose infusion during surgical anesthesia in an adult.
Topics: Acidosis, Lactic; Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Brain Stem Neoplasms; El | 2005 |
Evidence that erythrocytes are highly susceptible to exercise oxidative stress: FT-IR spectrometric studies at the molecular level.
Topics: Acidosis, Lactic; Erythrocytes; Exercise; Glucose; Hemoglobins; Humans; Lactic Acid; Oxidative Stres | 2005 |
[Treatment of symptomatic hyperlactatemia and lactic acidosis in HIV+ patients under nucleoside reverse transcriptase inhibitors].
Topics: Acidosis, Lactic; Adult; Anti-HIV Agents; Carnitine; HIV Infections; Humans; Lactic Acid; Male; Midd | 2005 |
[Lactic acidosis following antiretroviral therapy].
Topics: Acidosis, Lactic; Anti-HIV Agents; HIV Infections; Humans; Lactic Acid; Reverse Transcriptase Inhibi | 2005 |
Risk factors for and outcome of hyperlactatemia in HIV-infected persons: is there a need for routine lactate monitoring?
Topics: Acidosis, Lactic; Adult; Anti-HIV Agents; Drug Therapy, Combination; Female; HIV Infections; Humans; | 2005 |
Lactate production and exercise-induced metabolic acidosis: guilty or not guilty?
Topics: Acidosis, Lactic; Exercise; Exercise Test; Humans; Lactic Acid; Respiratory Function Tests | 2005 |
Lactic acidosis in sepsis: another commentary.
Topics: Acidosis, Lactic; Glucose; Humans; Lactic Acid; Pyruvic Acid; Sepsis | 2005 |
Lactate in a laubenpieper.
Topics: Acidosis, Lactic; Beriberi; Biomarkers; Diagnosis, Differential; Disease Progression; Humans; Lactic | 2005 |
The significance of elevated CSF lactate.
Topics: Acidosis, Lactic; Biomarkers; Child; Diagnosis, Differential; Humans; Inflammation; Lactic Acid; Met | 2005 |
Contraindications can damage your health--is metformin a case in point?
Topics: Acidosis, Lactic; Aging; Contraindications; Diabetes Mellitus, Type 2; Heart Diseases; Humans; Hypog | 2005 |
Introduction of an additional pathway for lactate oxidation in the treatment of lactic acidosis and mitochondrial dysfunction in Caenorhabditis elegans.
Topics: Acidosis, Lactic; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Energy Metabolism; | 2005 |
The anion gap does not accurately screen for lactic acidosis in emergency department patients.
Topics: Acidosis, Lactic; Adult; Aged; Anions; Cohort Studies; Emergency Service, Hospital; Female; Humans; | 2006 |
Serial transverse enteroplasty for management of refractory D-lactic acidosis in short-bowel syndrome.
Topics: Acidosis, Lactic; Adolescent; Anti-Bacterial Agents; Bacteria; Digestive System Surgical Procedures; | 2006 |
Comments on Point:Counterpoint series "Lactic acid accumulation is an advantage/disadvantage during muscle activity".
Topics: Acidosis, Lactic; Animals; Biological Transport; Humans; Lactic Acid; Muscle Contraction; Muscle Fat | 2006 |
Cardiovascular responses to oxygen inhalation after hemorrhage in anesthetized rats: hyperoxic vasoconstriction.
Topics: Acidosis, Lactic; Administration, Inhalation; Animals; Blood Pressure; Carbon Dioxide; Cardiovascula | 2007 |
Lactic acidosis in patients with neoplasms: an oncologic emergency.
Topics: Acidosis, Lactic; Humans; Lactic Acid; Neoplasms | 2006 |
Persistent lactic acidosis in neonatal hypoxic-ischaemic encephalopathy correlates with EEG grade and electrographic seizure burden.
Topics: Acidosis, Lactic; Asphyxia Neonatorum; Electroencephalography; Female; Humans; Hypoxia-Ischemia, Bra | 2008 |
Screening of foetal distress by assessment of umbilical cord lactate.
Topics: Acidosis, Lactic; Asphyxia Neonatorum; Biomarkers; Female; Fetal Blood; Fetal Distress; Humans; Infa | 2006 |
Additive protective effects of the addition of lactic acid and adrenaline on excitability and force in isolated rat skeletal muscle depressed by elevated extracellular K+.
Topics: Acidosis, Lactic; Animals; Carbon Dioxide; Chlorides; Dose-Response Relationship, Drug; Epinephrine; | 2007 |
Metabolic complications of HIV therapy.
Topics: Acidosis, Lactic; Anti-HIV Agents; Bone Diseases; Dyslipidemias; HIV Infections; Humans; Insulin Res | 2006 |
Combating muscle fatigue: extracellular lactic acidosis and catecholamines.
Topics: Acidosis, Lactic; Animals; Catecholamines; Exercise Tolerance; Extracellular Fluid; Humans; Hydrogen | 2007 |
Diagnostic accuracy of blood lactate-to-pyruvate molar ratio in the differential diagnosis of congenital lactic acidosis.
Topics: Acidosis, Lactic; Child; Diagnosis, Differential; Female; Hospitals, Pediatric; Humans; Lactic Acid; | 2007 |
Changes in urinary level and configuration ratio of D-lactic acid in patients with short bowel syndrome.
Topics: Acidosis, Lactic; Gas Chromatography-Mass Spectrometry; Humans; Lactic Acid; Short Bowel Syndrome; S | 2007 |
D-Lactic acid-induced neurotoxicity in a calf model.
Topics: Acidosis, Lactic; Animals; Ataxia; Cattle; Hydrochloric Acid; Lactic Acid; Models, Animal; Nervous S | 2007 |
Sustained low-efficiency dialysis as a treatment modality in a patient with lymphoma-associated lactic acidosis.
Topics: Acidosis, Lactic; Aged; Bicarbonates; Dialysis; Humans; Hydrogen-Ion Concentration; Lactates; Lactic | 2007 |
Central lactic acidosis, hyperventilation, and respiratory alkalosis: leading clinical features in a 3-year-old boy with malignant meningeal melanoma.
Topics: Acidosis, Lactic; Alkalosis, Respiratory; Child, Preschool; Diagnosis, Differential; Fatal Outcome; | 2008 |
Isolated sulfite oxidase deficiency in the newborn: lactic acidaemia and leukoencephalopathy.
Topics: Acidosis, Lactic; Brain Diseases; Homocysteine; Humans; Infant, Newborn; Lactic Acid; Male; Sulfite | 2007 |
Symptomatic hyperlactatemia associated with nucleoside analogue reverse-transcriptase inhibitor use in HIV-infected patients: a report of 24 cases in a resource-limited setting (Uganda).
Topics: Acidosis, Lactic; Adult; Anti-HIV Agents; Female; HIV Infections; Humans; Lactic Acid; Lamivudine; M | 2007 |
Regulation of initiation factors controlling protein synthesis on cultured astrocytes in lactic acid-induced stress.
Topics: Acidosis, Lactic; Animals; Animals, Newborn; Astrocytes; Brain Chemistry; Brain Ischemia; Cells, Cul | 2007 |
Acid-base disturbances in critically ill patients with cirrhosis.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Adult; APACHE; Critical Illness; Female; Hospital Mortality | 2007 |
Early and late activation of the voltage-gated proton channel during lactic acidosis through pH-dependent and -independent mechanisms.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Animals; Cell Line; Cell Size; Electric Stimulation; Enzyme | 2008 |
Lactate levels in Asian patients with type 2 diabetes mellitus on metformin and its association with dose of metformin and renal function.
Topics: Acidosis, Lactic; Asia; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; | 2007 |
Impact of female sex hormones on liver tissue lactic acidosis during ischemia.
Topics: Acidosis, Lactic; Animals; Estradiol; Female; Gonadal Steroid Hormones; Hydrogen; Lactic Acid; Liver | 2007 |
Cyclic stretch of human lung cells induces an acidification and promotes bacterial growth.
Topics: Acidosis; Acidosis, Lactic; Antimetabolites; Cell Line; Cell Survival; Colony Count, Microbial; Cult | 2008 |
Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia.
Topics: Acidosis, Lactic; Adrenomedullin; Animals; Cardiac Output; Drug Evaluation, Preclinical; Endotoxemia | 2007 |
Umbilical cord blood lactate: a valuable tool in the assessment of fetal metabolic acidosis.
Topics: Acidosis, Lactic; Blood Gas Analysis; Fetal Blood; Fetal Diseases; Humans; Infant, Newborn; Lactic A | 2008 |
Prevention of cerebral palsy during labour: role of foetal lactate.
Topics: Acidosis, Lactic; Apgar Score; Asphyxia; Cerebral Palsy; Extraction, Obstetrical; Female; Fetal Bloo | 2008 |
Symptomatic hyperlactatemia: lessons learned using a point-of-care device in a health care center- and nurse-based antiretroviral program in Rwanda.
Topics: Acidosis, Lactic; Acquired Immunodeficiency Syndrome; Ambulatory Care Facilities; Anti-HIV Agents; A | 2008 |
Comparison of acid-base models for prediction of hospital mortality after trauma.
Topics: Acidosis, Lactic; Adult; Bicarbonates; Biomarkers; Female; Hospital Mortality; Humans; Hydrogen-Ion | 2008 |
Extracellular pH defense against lactic acid in untrained and trained altitude residents.
Topics: Acclimatization; Acid-Base Equilibrium; Acidosis, Lactic; Adaptation, Physiological; Adult; Altitude | 2008 |
[D-lactic acidosis in a child with short bowel syndrome].
Topics: Acidosis, Lactic; Anti-Bacterial Agents; Child; Follow-Up Studies; Humans; Intestines; Lactic Acid; | 2008 |
Point: Lactic acid is the only physicochemical contributor to the acidosis of exercise.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Anaerobiosis; Animals; Chemical Phenomena; Chemistry, Physi | 2008 |
Risk factors for mortality in symptomatic hyperlactatemia among HIV-infected patients receiving antiretroviral therapy in a resource-limited setting.
Topics: Acidosis, Lactic; Adult; Anti-HIV Agents; Drug Therapy, Combination; Female; HIV Infections; Humans; | 2008 |
Use of tissue microdialysis to investigate hyperlactataemia following paediatric cardiac surgery.
Topics: Abdominal Wall; Acidosis, Lactic; Biomarkers; Child, Preschool; Epinephrine; Feasibility Studies; Fo | 2008 |
Mitochondrial lactate oxidation complex and an adaptive role for lactate production.
Topics: Acidosis, Lactic; Adaptation, Physiological; Basigin; Electron Transport Complex IV; Humans; L-Lacta | 2008 |
Severe lactic acidosis secondary to minocycline in a teenager with infectious mononucleosis and mitochondrial myopathy.
Topics: Acidosis, Lactic; Acne Vulgaris; Adolescent; Anti-Bacterial Agents; DNA, Mitochondrial; Female; Huma | 2008 |
Severe hyperlactatemia with normal base excess: a quantitative analysis using conventional and Stewart approaches.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Aged; Bicarbonates; Blood Gas Analysis; Carbon Dioxide; Chl | 2008 |
Cardiac biomarkers, electrolytes, and other analytes in collapsed marathon runners: implications for the evaluation of runners following competition.
Topics: Acidosis, Lactic; Adult; Biomarkers; Blood Chemical Analysis; Calcium; Female; Humans; Hyponatremia; | 2008 |
Contribution of the respiratory muscles to the lactic acidosis of heavy exercise in COPD.
Topics: Acidosis, Lactic; Adult; Exercise; Exercise Tolerance; Female; Forced Expiratory Volume; Humans; Lac | 1995 |
[Metformin in patients with coronary disease?].
Topics: Acidosis, Lactic; Contraindications; Coronary Disease; Humans; Lactates; Lactic Acid; Metformin; Ris | 1995 |
Prolonged survival in pyruvate carboxylase deficiency: lack of correlation with enzyme activity in cultured fibroblasts.
Topics: Acidosis, Lactic; Adult; Alanine; Cells, Cultured; Child; Child, Preschool; Female; Fibroblasts; Hum | 1995 |
Detection of liver ischemia using microdialysis during experimental peritonitis in pigs.
Topics: Acidosis, Lactic; Animals; Disease Models, Animal; Extracellular Space; Female; Hypoxanthine; Hypoxa | 1994 |
D-lactic acidosis in a patient with jejunoileal bypass.
Topics: Acidosis, Lactic; Brain Diseases, Metabolic; Colon; Female; Humans; Jejunoileal Bypass; Lactates; La | 1995 |
Molecular analysis of abnormal pyruvate dehydrogenase in a patient with thiamine-responsive congenital lactic acidemia.
Topics: Acidosis, Lactic; Base Sequence; Decarboxylation; Humans; Immunoblotting; Infant, Newborn; Lactates; | 1994 |
D-lactic acidemia and aciduria in pediatric and adult patients with short bowel syndrome.
Topics: Acidosis, Lactic; Adult; Child, Preschool; Circadian Rhythm; Female; Humans; Infant; Lactates; Lacti | 1995 |
Cerebral dysgenesis and lactic acidemia: an MRI/MRS phenotype associated with pyruvate dehydrogenase deficiency.
Topics: Acidosis, Lactic; Agenesis of Corpus Callosum; Brain; Brain Damage, Chronic; Brain Diseases, Metabol | 1994 |
Determination of the anaerobic threshold by gas exchange: biochemical considerations, methodology and physiological effects.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Adult; Anaerobic Threshold; Bicarbonates; Carbon Dioxide; E | 1994 |
Effect of lactic and CO2 acidosis on neuronal function following glucose-oxygen deprivation in rat hippocampal slices.
Topics: Acidosis, Lactic; Acidosis, Respiratory; Animals; Carbon Dioxide; Female; Glucose; Hippocampus; Hydr | 1994 |
Prevention of acidosis and laminitis associated with grain feeding in horses.
Topics: Acidosis, Lactic; Animal Feed; Animals; Eating; Edible Grain; Feces; Foot Diseases; Hoof and Claw; H | 1994 |
Stability of plasma lactate in vitro in the presence of antiglycolytic agents.
Topics: Acidosis, Lactic; Blood Specimen Collection; Drug Stability; Glycolysis; Humans; Lactates; Lactic Ac | 1994 |
[Effects of fructose on left ventricular function during hypoxia].
Topics: Acidosis, Lactic; Anesthesia; Animals; Blood Glucose; Dogs; Fructose; Hypoxia; Lactates; Lactic Acid | 1994 |
Lactic acidosis and mitochondrial dysfunction in two children with peroxisomal disorders.
Topics: Acidosis, Lactic; Adrenoleukodystrophy; Catalase; Cells, Cultured; Citrate (si)-Synthase; Female; Fi | 1993 |
Skeletal muscle mitochondrial myopathy as a cause of exercise intolerance in a horse.
Topics: Acidosis, Lactic; Animals; Female; Horse Diseases; Horses; Lactates; Lactic Acid; Mitochondrial Myop | 1994 |
The effect of hypercarbia on age-related changes in cerebral glucose transport and glucose-modulated agonal glycolytic rates.
Topics: Acidosis, Lactic; Age Factors; Animals; Animals, Newborn; Animals, Suckling; Biological Transport; B | 1993 |
Bicarbonate does not increase left ventricular contractility during L-lactic acidemia in pigs.
Topics: Acidosis, Lactic; Animals; Bicarbonates; Heart Ventricles; Hydrogen-Ion Concentration; Lactates; Lac | 1994 |
Relationship between intracellular pH, extracellular pH, and ventilation during dilution acidosis.
Topics: Acidosis, Lactic; Animals; Brain; Ducks; Extracellular Space; Female; Hydrogen-Ion Concentration; Hy | 1994 |
Lactated Ringer's solution alleviates brain trauma-precipitated lactic acidosis in hemorrhagic shock.
Topics: Acidosis, Lactic; Animals; Blood Glucose; Brain Injuries; Cerebral Hemorrhage; Gases; Hydrogen-Ion C | 1993 |
Training does not affect zero-trans lactate transport across mixed rat skeletal muscle sarcolemmal vesicles.
Topics: Acidosis, Lactic; Animals; Carboxylic Acids; Citrate (si)-Synthase; Female; Kinetics; Lactates; Lact | 1993 |
Lactic acidosis and acute ethanol intoxication.
Topics: Acidosis, Lactic; Adult; Aged; Alcoholic Intoxication; Ethanol; Female; Humans; Lactates; Lactic Aci | 1994 |
Bicarbonate does not increase left ventricular contractility during L-lactic acidemia in pigs.
Topics: Acidosis, Lactic; Animals; Bicarbonates; Blood Pressure; Carbon Dioxide; Cardiac Output; Cardiac Pac | 1993 |
Comparison of gas exchange, lactate, and lactic acidosis thresholds in patients with chronic obstructive pulmonary disease.
Topics: Acidosis, Lactic; Anaerobic Threshold; Bicarbonates; Carbon Dioxide; Exercise Test; Humans; Lactates | 1993 |
Proton magnetic resonance spectroscopy studies in lactic acidosis and mitochondrial disorders.
Topics: Acidosis, Lactic; Aspartic Acid; Brain; Child; Child, Preschool; Choline; Creatine; Female; Humans; | 1993 |
O2 uptake kinetics in response to exercise. A measure of tissue anaerobiosis in heart failure.
Topics: Acidosis, Lactic; Adult; Aged; Anaerobiosis; Catecholamines; Energy Metabolism; Exercise; Exercise T | 1993 |
D-lactic acidosis: a treatable encephalopathy in pediatric patients.
Topics: Acidosis, Lactic; Brain Diseases, Metabolic; Enteral Nutrition; Humans; Infant; Lactates; Lactic Aci | 1993 |
[Measuring lactate concentration with electrodes].
Topics: Acidosis, Lactic; Blood Gas Analysis; Critical Care; Electrodes; Humans; Lactates; Lactic Acid; Refe | 1995 |
Leigh disease with deficiency of lipoamide dehydrogenase: treatment failure with dichloroacetate.
Topics: Acidosis, Lactic; Amino Acids, Branched-Chain; Child, Preschool; Dichloroacetic Acid; Dihydrolipoami | 1996 |
Alkali therapy extends the period of survival during hypoxia: studies in rats.
Topics: Acidosis, Lactic; Adenosine Triphosphate; Alkalies; Anaerobiosis; Animals; Glycolysis; Hypoxia; Lact | 1996 |
Acute necrotizing pancreatitis, lactic acidosis and prolonged hypoglycemia in a hemodialysed patient--a logical but unfortunately fatal combination.
Topics: Acidosis, Lactic; Blood Gas Analysis; Blood Glucose; Diabetes Mellitus, Type 2; Fatal Outcome; Femal | 1996 |
Pulmonary lactate release in patients with sepsis and the adult respiratory distress syndrome.
Topics: Acidosis, Lactic; Adolescent; Adult; Aged; Aged, 80 and over; Cardiac Output; Female; Gastric Mucosa | 1996 |
Continuous venovenous hemofiltration with dialysis and lactate clearance in critically ill patients.
Topics: Acidosis, Lactic; Critical Illness; Hemodiafiltration; Humans; Lactic Acid | 1997 |
Effect of continuous venovenous hemofiltration with dialysis on lactate clearance in critically ill patients.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adolescent; Adult; Aged; Critical Illness; Dialysis Solutions | 1997 |
Comparison of a lactate-versus acetate-based hemofiltration replacement fluid in patients with acute renal failure.
Topics: Acetates; Acid-Base Equilibrium; Acidosis, Lactic; Acute Kidney Injury; APACHE; Bicarbonates; Blood | 1997 |
Effects of moderate hypothermia on extracellular lactic acid and amino acids after severe compression injury of rat spinal cord.
Topics: Acidosis, Lactic; Amino Acids; Animals; Excitatory Amino Acids; Extracellular Space; Hypothermia, In | 1997 |
Lactic acidosis associated with Glucophage use in a man with normal renal and hepatic function.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Drug Therapy, Combination; Human | 1997 |
Role of bacteria in the pathogenesis of short bowel syndrome-associated D-lactic acidemia.
Topics: Acidosis, Lactic; Administration, Oral; Adult; Anti-Bacterial Agents; Bacterial Physiological Phenom | 1997 |
Bicarbonate haemodialysis as a treatment of metformin overdose.
Topics: Acidosis, Lactic; Adult; Bicarbonates; Buffers; Drug Overdose; Humans; Hypoglycemic Agents; Lactic A | 1997 |
[Effects of steroids on hepatic ATP and L/P ratio in rats subjected to acute hemorrhage].
Topics: Acidosis, Lactic; Acute Disease; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Glycogen | 1997 |
Fixed acid uptake by visceral organs during early endotoxemia.
Topics: Acidosis; Acidosis, Lactic; Acids; Animals; Bicarbonates; Biological Transport, Active; Body Fluids; | 1997 |
Effect of extreme metabolic acidosis on oxygen delivery capacity of the blood--an in vitro investigation of changes in the oxyhemoglobin dissociation curve in blood with pH values of approximately 6.30.
Topics: Acidosis, Lactic; Acidosis, Respiratory; Blood Gas Analysis; Female; Humans; Hydrogen-Ion Concentrat | 1997 |
Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: a possible role for protein tyrosine kinase.
Topics: Acidosis, Lactic; Animals; Cells, Cultured; Cyclooxygenase 2; Endotoxemia; Endotoxins; Enzyme Induct | 1997 |
Lactic acidosis and oxygen debt in African children with severe anaemia.
Topics: Acidosis, Lactic; Anemia; Blood Transfusion; Child; Child, Preschool; Female; Humans; Infant; Kenya; | 1997 |
Fecal microflora in a patient with short-bowel syndrome and identification of dominant lactobacilli.
Topics: Acidosis, Lactic; Base Composition; Base Sequence; Child, Preschool; Colony Count, Microbial; DNA Pr | 1997 |
Prolonged pneumoperitoneum at 15 mmHg causes lactic acidosis.
Topics: Acidosis, Lactic; Aged; Carbon Dioxide; Colon, Sigmoid; Female; Humans; Hydrogen-Ion Concentration; | 1998 |
Distribution of lactate and other ions in inactive skeletal muscle: influence of hyperkalemic lactacidosis.
Topics: Acidosis, Lactic; Animals; Hyperkalemia; Ion Transport; Lactic Acid; Male; Membrane Potentials; Musc | 1997 |
Metabolic and hemodynamic responses of lower limb during exercise in patients with COPD.
Topics: Acidosis, Lactic; Aged; Carbon Dioxide; Exercise; Hemodynamics; Humans; Hydrogen-Ion Concentration; | 1998 |
Hyperlactatemia during acute severe asthma.
Topics: Acidosis, Lactic; Acute Disease; Adult; Arteries; Asthma; Blood Gas Analysis; Disease Progression; F | 1998 |
Systemic and regional pCO2 gradients as markers of intestinal ischaemia.
Topics: Acidosis, Lactic; Acidosis, Respiratory; Animals; Biomarkers; Carbon Dioxide; Disease Models, Animal | 1998 |
L-2-hydroxyglutaric aciduria and lactic acidosis.
Topics: Acidosis, Lactic; Alcohol Oxidoreductases; Child, Preschool; Glutarates; Humans; Lactic Acid; Liver; | 1998 |
Maturational changes in cerebral lactate and acid clearance following ischemia measured in vivo using magnetic resonance spectroscopy and microdialysis.
Topics: Acidosis, Lactic; Age Factors; Animals; Animals, Newborn; Brain Ischemia; Cerebral Cortex; Lactic Ac | 1999 |
Regional changes in cerebral extracellular glucose and lactate concentrations following severe cortical impact injury and secondary ischemia in rats.
Topics: Acidosis, Lactic; Animals; Blood Gas Analysis; Body Temperature; Brain Chemistry; Brain Injuries; Br | 1999 |
[Severe lactic acidosis disease disclosing milk-protein intolerance to cows' milk].
Topics: Acidosis, Lactic; Animals; Fasting; Female; Humans; Infant; Lactic Acid; Milk; Milk Hypersensitivity | 1999 |
Lactic acidosis in metformin-treated patients. Prognostic value of arterial lactate levels and plasma metformin concentrations.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Female; Humans; Hydrogen-Ion Concentration; Hypogl | 1999 |
Adrenergic antagonists reduce lactic acidosis in response to hemorrhagic shock.
Topics: Acidosis, Lactic; Adrenergic alpha-Antagonists; Adrenergic Antagonists; Adrenergic beta-Antagonists; | 1999 |
Simulated airplane flight increases plasma lactate in fetal rabbits.
Topics: Acidosis, Lactic; Aerospace Medicine; Altitude; Animals; Disease Models, Animal; Female; Fetal Hypox | 1999 |
Blood lactate accumulation and muscle deoxygenation during incremental exercise.
Topics: Acidosis, Lactic; Adult; Exercise; Exercise Test; Hemoglobins; Humans; Lactic Acid; Male; Muscle, Sk | 1999 |
Immunisation against lactic acidosis in cattle.
Topics: Acidosis, Lactic; Animals; Antibodies, Bacterial; Bacterial Vaccines; Cattle; Cattle Diseases; Energ | 1999 |
Lactic acid-induced increase of extracellular dopamine measured by microdialysis in rat striatum: evidence for glutamatergic and oxidative mechanisms.
Topics: Acidosis, Lactic; Animals; Antioxidants; Chromans; Chromatography, High Pressure Liquid; Corpus Stri | 1999 |
Actively phosphorylating mitochondria are more resistant to lactic acidosis than inactive mitochondria.
Topics: Acidosis, Lactic; Adenosine Diphosphate; Animals; Disease Susceptibility; Hydrogen-Ion Concentration | 1999 |
Unmeasured anions identified by the Fencl-Stewart method predict mortality better than base excess, anion gap, and lactate in patients in the pediatric intensive care unit.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Bicarbonates; Blood Gas Analysis; Carbon Dioxide; Chlorides | 1999 |
Effect of recovery duration on muscular power and blood lactate during the bench press exercise.
Topics: Acidosis, Lactic; Adult; Humans; Lactic Acid; Male; Muscle Fatigue; Muscle, Skeletal; Physical Endur | 1999 |
Artifactual elevation of measured plasma L-lactate concentration in the presence of glycolate.
Topics: Acidosis, Lactic; Blood Gas Analysis; Blood Glucose; Diagnosis, Differential; Ethylene Glycol; Forma | 1999 |
Effect of ruminal glucose infusion on dry matter intake, urinary nitrogen composition, and serum metabolite and hormone profiles in Ewes.
Topics: Acidosis, Lactic; Animals; Energy Intake; Glucose; Hydrogen-Ion Concentration; Lactic Acid; Nitrogen | 1999 |
The golden hour and the silver day: detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma.
Topics: Acidosis, Lactic; Adult; Critical Care; Female; Hemodynamics; Humans; Injury Severity Score; Ischemi | 1999 |
The golden hour and the silver day: detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma.
Topics: Acidosis, Lactic; Adult; Critical Care; Female; Hemodynamics; Humans; Injury Severity Score; Ischemi | 1999 |
The golden hour and the silver day: detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma.
Topics: Acidosis, Lactic; Adult; Critical Care; Female; Hemodynamics; Humans; Injury Severity Score; Ischemi | 1999 |
The golden hour and the silver day: detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma.
Topics: Acidosis, Lactic; Adult; Critical Care; Female; Hemodynamics; Humans; Injury Severity Score; Ischemi | 1999 |
Lactic acidosis in metformin therapy.
Topics: Acidosis, Lactic; Adult; Aged; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lactic Acid; | 1999 |
Cocaine and exercise: alpha-1 receptor blockade does not alter muscle glycogenolysis or blood lactacidosis.
Topics: Acidosis, Lactic; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Co | 2000 |
Critical capillary PO2 and the role of lactate production in oxyhemoglobin dissociation during exercise.
Topics: Acidosis, Lactic; Adult; Blood Gas Analysis; Buffers; Capillaries; Cardiac Output, Low; Exercise; Fe | 1999 |
Evolution of lactate/pyruvate and arterial ketone body ratios in the early course of catecholamine-treated septic shock.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Case-Control Studies; Catecholamines; Female; Hemo | 2000 |
Impaired hepatic extraction and increased splanchnic production contribute to lactic acidosis in canine sepsis.
Topics: Acidosis, Lactic; Animals; Critical Care; Dogs; Escherichia coli Infections; Lactic Acid; Liver; Oxy | 2000 |
Accumulation of lactate by supercooled hatchlings of the painted turtle (Chrysemys picta): implications for overwinter survival.
Topics: Acidosis, Lactic; Analysis of Variance; Animals; Animals, Newborn; Cold Temperature; Energy Metaboli | 2000 |
Early hyperlactataemia in critically ill children.
Topics: Acidosis, Lactic; Adolescent; Child; Child, Preschool; Critical Illness; Female; Humans; Incidence; | 2000 |
Relationship among oxygenation, myoelectric activity, and lactic acid accumulation in vastus lateralis muscle during exercise with constant work rate.
Topics: Acidosis, Lactic; Adult; Electromyography; Exercise; Exercise Test; Humans; Lactic Acid; Male; Muscl | 2000 |
[Serum lactate levels as an indicator of tissue hypoxia in severely ill patients].
Topics: Acidosis, Lactic; Cell Hypoxia; Humans; Lactic Acid; Severity of Illness Index; Shock; Sodium Bicarb | 2000 |
Time-pattern of lactate and lactate to pyruvate ratio in the first 24 hours of intensive care emergency admissions.
Topics: Acidosis, Lactic; APACHE; Biomarkers; Critical Care; Emergencies; Female; Finland; Glasgow Coma Scal | 2000 |
[Serum lactate level as an indicator of tissue hypoxia in severely ill patients].
Topics: Acidosis, Lactic; Cell Hypoxia; Critical Illness; Humans; Lactic Acid; Risk Factors | 2000 |
Osmolar gap metabolic acidosis in a 60-year-old man treated for hypoxemic respiratory failure.
Topics: Acidosis, Lactic; Drug Combinations; Humans; Hypnotics and Sedatives; Hypoxia; Infusions, Intravenou | 2000 |
Depletion of lactate by dichloroacetate reduces cardiac efficiency after hemorrhagic shock.
Topics: Acidosis, Lactic; Animals; Dichloroacetic Acid; Dogs; Drug Evaluation, Preclinical; Energy Metabolis | 2000 |
Rapid enantiomeric differentiation of urinary metabolites in a patient with bacterial overgrowth syndrome.
Topics: Acidosis, Lactic; Bacteria; Child, Preschool; Gas Chromatography-Mass Spectrometry; Humans; Lactic A | 2000 |
Sodium bicarbonate controversy in lactic acidosis.
Topics: Acidosis, Lactic; Humans; Infusions, Intravenous; Lactic Acid; Sodium Bicarbonate; Treatment Outcome | 2000 |
[Serum lactate level as an indicator of tissue hypoxia in severely ill patients].
Topics: Acidosis, Lactic; Cell Hypoxia; Humans; Lactic Acid; Severity of Illness Index; Shock | 2000 |
Oxygen consumption, carbon dioxide production and lactic acid during normothermic cardiopulmonary bypass.
Topics: Acidosis, Lactic; Aged; Blood Gas Analysis; Carbon Dioxide; Cardiopulmonary Bypass; Female; Hemoglob | 2000 |
Gas exchange responses to continuous incremental cycle ergometry exercise in primary pulmonary hypertension in humans.
Topics: Acidosis, Lactic; Adult; Case-Control Studies; Exercise; Exercise Test; Female; Heart Failure; Human | 2000 |
Respiratory compensation point during incremental exercise as related to hypoxic ventilatory chemosensitivity and lactate increase in man.
Topics: Acidosis, Lactic; Adult; Carbon Dioxide; Carotid Body; Female; Humans; Hypercapnia; Hypoxia; Lactic | 2000 |
Osteoblast expression of vascular endothelial growth factor is modulated by the extracellular microenvironment.
Topics: Acidosis, Lactic; Animals; Animals, Newborn; Cells, Cultured; Endothelial Growth Factors; Extracellu | 2001 |
Don't forget to test for D-lactic acid in short bowel syndrome.
Topics: Acidosis, Lactic; Central Nervous System Diseases; Child, Preschool; Female; Humans; Lactic Acid; Sh | 2000 |
Effects of cardiogenic shock on lactate and glucose metabolism after heart surgery.
Topics: Acidosis, Lactic; Adult; Aged; Bilirubin; Cardiac Surgical Procedures; Case-Control Studies; Female; | 2000 |
Type A lactic acidosis in cardiogenic shock.
Topics: Acidosis, Lactic; Anaerobiosis; Humans; Lactic Acid; Metabolic Clearance Rate; Oxygen Consumption; S | 2000 |
Holocarboxylase synthetase deficiency: urinary metabolites masked by gross ketosis.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis, Lactic; Carbon-Nitrogen Ligases; Carboxy-Lyases; Chi | 2000 |
Blood lactate determined by a portable device in critically ill patients.
Topics: Acidosis, Lactic; Critical Illness; Equipment and Supplies; Female; Humans; Lactic Acid; Male; Middl | 2000 |
Evidence against a major role of plasmalogens in the resistance of astrocytes in lactic acid-induced oxidative stress in vitro.
Topics: Acidosis, Lactic; Animals; Animals, Newborn; Antioxidants; Astrocytes; Cells, Cultured; Cerebral Cor | 2001 |
The hepatosplanchnic area is not a common source of lactate in patients with severe sepsis.
Topics: Acidosis, Lactic; Aged; APACHE; Blood Flow Velocity; Blood Gas Analysis; Carbon Dioxide; Catecholami | 2001 |
Effect of NaHCO3 on cardiac energy metabolism and contractile function during hypoxemia.
Topics: Acidosis, Lactic; Analysis of Variance; Animals; Blood Gas Analysis; Disease Models, Animal; Dogs; D | 2001 |
Peritoneal dialysis in an infant with type 1 diabetes and hyperosmolar coma.
Topics: Acidosis, Lactic; Dehydration; Diabetes Mellitus, Type 1; Female; Follow-Up Studies; Humans; Hypergl | 2001 |
[An autopsy case of neonatal lactic acidosis].
Topics: Acidosis, Lactic; Atrophy; Autopsy; Body Fluids; Brain; Cardiomegaly; Epilepsy, Generalized; Fatal O | 2001 |
Confusion after antibiotics.
Topics: Acidosis, Lactic; Anti-Bacterial Agents; Confusion; Female; Humans; Lactic Acid; Lacticaseibacillus | 2001 |
Osteopenia in HIV-infected men: association with asymptomatic lactic acidemia and lower weight pre-antiretroviral therapy.
Topics: Absorptiometry, Photon; Acidosis, Lactic; Adult; Anti-HIV Agents; Body Composition; Body Weight; Bon | 2001 |
Chronic hyperlactatemia in HIV-infected patients taking antiretroviral therapy.
Topics: Acidosis, Lactic; Adult; Antiretroviral Therapy, Highly Active; Chronic Disease; Data Interpretation | 2001 |
Management of hyperlactatemia: no need for routine lactate measurements.
Topics: Acidosis, Lactic; Anti-HIV Agents; HIV Infections; Humans; Lactic Acid; Mitochondria; Monitoring, Ph | 2001 |
[Recurrent encephalopathy after small bowel resection. Implication of D-lactate].
Topics: Acidosis, Lactic; Brain Diseases, Metabolic; Confusion; Humans; Intestine, Small; Ischemia; Lactic A | 2001 |
[Impact of lactic acid fermentation in the large intestine on acute lactic acidosis in cattle].
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Animals; Cattle; Cattle Diseases; Dietary Carbohydrates; Fe | 2000 |
Both L- and D-lactate contribute to metabolic acidosis in diarrheic calves.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Animals; Animals, Suckling; Bacteria; Carbon Dioxide; Cattl | 2001 |
Of power plants and energy shortages.
Topics: Acidosis, Lactic; Anti-HIV Agents; HIV Infections; Humans; Lactic Acid; Mitochondria; Reverse Transc | 2001 |
Bone damage--more than just nukes involved.
Topics: Acidosis, Lactic; Anti-HIV Agents; Bone Resorption; HIV Infections; Humans; Lactic Acid; Life Style; | 2001 |
Lactic acid elevation in extramitochondrial childhood neurodegenerative diseases.
Topics: Acidosis, Lactic; Brain; Coenzymes; Female; Genetic Carrier Screening; Heredodegenerative Disorders, | 2001 |
Effects of dobutamine on critical capillary PO(2) and lactic acidosis threshold in patients with cardiovascular disease.
Topics: Acidosis, Lactic; Aged; Blood Gas Analysis; Blood Pressure; Capillaries; Coronary Disease; Dobutamin | 2001 |
Role of pH on the calcium ion dependence of the nitric oxide synthase in the carp brain.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Animals; Brain; Calcium; Carps; Cerebrovascular Circulation | 2001 |
CD8(+)-T-cell depletion ameliorates circulatory shock in Plasmodium berghei-infected mice.
Topics: Acidosis, Lactic; Adenosine Triphosphatases; Animals; Anion Transport Proteins; Capillary Permeabili | 2001 |
Blocking of acidosis-mediated apoptosis by a reduction of lactate dehydrogenase activity through antisense mRNA expression.
Topics: Acidosis, Lactic; Animals; Apoptosis; Chimera; CHO Cells; Cricetinae; Gene Expression; Glycolysis; H | 2001 |
Prenatal diagnosis of pyruvate dehydrogenase deficiency using magnetic resonance imaging.
Topics: Acidosis, Lactic; Adult; Cerebral Cortex; Cerebral Ventricles; Cerebrospinal Fluid; Diseases in Twin | 2001 |
Renal manifestations of congenital lactic acidosis.
Topics: Acidosis, Lactic; Adolescent; Adult; Bicarbonates; Blood Urea Nitrogen; Calcium; Child; Child, Presc | 2002 |
[Analysis of anionic gap and lactic acid levels significance in metabolic acidosis in small children].
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Anions; Child, Preschool; Diarrhea, Infantile; Female; Huma | 1995 |
Lactacidemia in asymptomatic HIV-infected subjects receiving nucleoside reverse-transcriptase inhibitors.
Topics: Acidosis, Lactic; Adult; Antiretroviral Therapy, Highly Active; HIV Infections; Humans; Lactic Acid; | 2002 |
Lactic acidosis following heart transplantation: a common phenomenon?
Topics: Acidosis, Lactic; Adolescent; Adrenergic beta-Agonists; Adult; Cardiotonic Agents; Combined Modality | 2002 |
Hyperlactatemia syndromes in people with HIV infection.
Topics: Acidosis, Lactic; Anti-HIV Agents; Chemical and Drug Induced Liver Injury; HIV Infections; Homeostas | 2002 |
Lactacidosis in the neonate is minimized by prenatal detection of congenital heart disease.
Topics: Acidosis, Lactic; Female; Heart Defects, Congenital; Humans; Hydrogen-Ion Concentration; Infant, New | 2002 |
Arterial norepinephrine changes in patients with septic shock.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Arteries; Epinephrine; Female; Humans; Lactates; L | 1992 |
Plasma ionized calcium and blood lactate concentrations are inversely associated in human lactic acidosis.
Topics: Acidosis, Lactic; Adult; Aged; Calcium; Female; Humans; Hydrogen-Ion Concentration; Lactates; Lactic | 1992 |
Postoperative TPN-induced lactic acidosis.
Topics: Acidosis, Lactic; Humans; Lactates; Lactic Acid; Parenteral Nutrition, Total; Stomach Neoplasms; Thi | 1992 |
Lactic acidosis from thiamine deficiency during parenteral nutrition in a two-year-old boy.
Topics: Acidosis, Lactic; Child, Preschool; Humans; Intestinal Atresia; Jejunum; Lactates; Lactic Acid; Male | 1992 |
Early metabolic effects of sepsis in the preterm infant: lactic acidosis and increased glucose requirement.
Topics: Acidosis, Lactic; Analysis of Variance; Bacterial Infections; Biomarkers; Blood Glucose; Glucose; Hu | 1992 |
Chronic lactic acidosis in a patient with acquired immunodeficiency syndrome and mitochondrial myopathy: biochemical studies.
Topics: Acidosis, Lactic; Acquired Immunodeficiency Syndrome; Adult; Exercise; Humans; Kidney; Lactates; Lac | 1992 |
Effects of hyperglycemia on the time course of changes in energy metabolism and pH during global cerebral ischemia and reperfusion in rats: correlation of 1H and 31P NMR spectroscopy with fatty acid and excitatory amino acid levels.
Topics: Acidosis, Lactic; Animals; Aspartic Acid; Brain Chemistry; Brain Ischemia; Energy Metabolism; Fatty | 1992 |
Is the anaerobic threshold truly anaerobic?
Topics: Acidosis, Lactic; Anaerobic Threshold; Anaerobiosis; Exercise; Exercise Test; Humans; Lactates; Lact | 1992 |
Lactic acidosis: effect of treatment on intracellular pH and energetics in living rat heart.
Topics: Acidosis, Lactic; Animals; Bicarbonates; Energy Metabolism; Hemodynamics; Hydrogen; Hydrogen-Ion Con | 1992 |
Alpha-ketoglutarate dehydrogenase deficiency presenting as congenital lactic acidosis.
Topics: Acidosis, Lactic; Humans; Infant, Newborn; Ketoglutarate Dehydrogenase Complex; Ketone Bodies; Lacta | 1992 |
Alterations in anion gap following cardiopulmonary bypass.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Blood Gas Analysis; Blood P | 1992 |
Hyperlactataemia and metabolic acidosis during haemofiltration using lactate-buffered fluids.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Buffers; Female; Hemofiltrati | 1991 |
[Thiamine deficiency as a cause of life threatening lactic acidosis in total parenteral nutrition].
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Adult; Cholecystectomy; Choledochostomy; Colostomy; Critica | 1991 |
[Lactic acidosis inpatients with diabetes mellitus].
Topics: Acidosis, Lactic; Adolescent; Adult; Aged; Bicarbonates; Blood Glucose; Diabetic Ketoacidosis; Dichl | 1991 |
Lactate metabolism in inactive skeletal muscle during lactacidosis.
Topics: Acidosis, Lactic; Animals; Glucose; Hindlimb; Lactates; Lactic Acid; Male; Muscles; Oxygen Consumpti | 1991 |
Lactic acid levels as a prognostic measure in acutely Ill patients.
Topics: Acidosis, Lactic; Acute Disease; Adolescent; Child; Child, Preschool; Female; Humans; Hydrogen-Ion C | 1991 |
Marked reduction in CSF lactate and pyruvate levels after CoQ therapy in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS).
Topics: Acidosis, Lactic; Adult; Agnosia; Cerebrovascular Disorders; Delirium; Dose-Response Relationship, D | 1991 |
Postprandial plasma D-lactate concentrations after yogurt ingestion.
Topics: Acidosis, Lactic; Adult; Bicarbonates; Female; Humans; Hydrogen-Ion Concentration; Lactates; Lactic | 1991 |
Extracellular pH in the brain during ischemia: relationship to the severity of lactic acidosis.
Topics: Acidosis, Lactic; Animals; Brain; Carbon Dioxide; Hydrogen-Ion Concentration; Hyperglycemia; Ischemi | 1991 |
31P-NMR study of normoxic and anoxic perfused turtle heart during graded CO2 and lactic acidosis.
Topics: Acidosis, Lactic; Adenosine Triphosphate; Animals; Carbon Dioxide; Female; Heart; Heart Rate; Hydrog | 1991 |
Vascular lactic acid infusions do not alter the incidence of fetal breathing movements or their inhibition by acute hypoxemia.
Topics: Acidosis, Lactic; Animals; Blood Glucose; Blood Pressure; Carbon Dioxide; Female; Heart Rate; Hypoxi | 1991 |
Lack of a relationship between induced changes in oxygen consumption and changes in lactate levels.
Topics: Acidosis, Lactic; Blood Transfusion; Dobutamine; Female; Fluid Therapy; Humans; Infections; Lactates | 1991 |
Lactate and acid base changes in the critically ill.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Catecholamines; Hemofiltration; Humans; Lactates; | 1991 |
Therapeutic effect of sodium dichloroacetate on visual and auditory hallucinations in a patient with MELAS.
Topics: Acidosis, Lactic; Administration, Oral; Adult; Auditory Perception; Dichloroacetic Acid; Hallucinati | 1991 |
Comparative effects of bicarbonate and dichloroacetate in newborn swine with hypoxic lactic acidosis.
Topics: Acidosis, Lactic; Animals; Animals, Newborn; Bicarbonates; Blood Pressure; Cardiac Output; Dichloroa | 1990 |
The use of skin fibroblast cultures in the detection of respiratory chain defects in patients with lacticacidemia.
Topics: Acidosis, Lactic; Brain Diseases; Cells, Cultured; Cytochrome-c Oxidase Deficiency; Fibroblasts; Hum | 1990 |
Lactic acidosis increases tumor necrosis factor secretion and transcription in vitro.
Topics: Acidosis, Lactic; Animals; Ascitic Fluid; Cell Survival; Cells, Cultured; Female; Gene Expression; H | 1990 |
Hyperlactatemia and increasing metabolic acidosis in hepatorenal failure treated by hemofiltration.
Topics: Acidosis, Lactic; Aged; Buffers; Dialysis Solutions; Female; Hemofiltration; Hepatorenal Syndrome; H | 1990 |
A semiquantitative filter paper method for screening for lactic acidemia.
Topics: Acidosis, Lactic; Filtration; Humans; Lactates; Lactic Acid; Mass Screening | 1990 |
Biguanide-induced lactic acidosis.
Topics: Acidosis, Lactic; Adult; Diabetes Mellitus, Type 2; Follow-Up Studies; Humans; Lactates; Lactic Acid | 1990 |
Propylene glycol ingestion causes D-lactic acidosis.
Topics: Acidosis, Lactic; Animals; Cats; Dose-Response Relationship, Drug; Female; Lactates; Lactic Acid; Ma | 1990 |
Dietary management of D-lactic acidosis in short bowel syndrome.
Topics: Acidosis, Lactic; Carbohydrate Metabolism; Child; Colon; Dietary Carbohydrates; Female; Humans; Lact | 1990 |
D-lactic acidosis in short bowel syndrome--an examination of possible mechanisms.
Topics: Acidosis, Lactic; Adult; Blood Glucose; Female; Humans; Isomerism; Lactates; Lactic Acid; Malabsorpt | 1990 |
Distribution of pulmonary vascular resistance during lactic acid infusion in dogs.
Topics: Acidosis, Lactic; Animals; Blood Pressure; Capillaries; Cardiac Output; Dogs; Erythrocyte Membrane; | 1990 |
Involvement of lactic acidosis in anoxia-induced perturbations of synaptosomal function.
Topics: Acidosis, Lactic; Animals; Glucose; Hypoxia; Lactates; Lactic Acid; Male; Rats; Rats, Inbred Strains | 1990 |
Oxygen uptake/supply dependency. Effects of short-term dobutamine infusion.
Topics: Acidosis, Lactic; Aged; Bacterial Infections; Dobutamine; Female; Heart Failure; Humans; Lactates; L | 1990 |
Effect of acute acidemia on blood biochemical variables in healthy ponies.
Topics: Acidosis, Lactic; Animals; Carbonic Acid; Horses; Hydrochloric Acid; Hydrogen-Ion Concentration; Lac | 1990 |
The effect of cardiopulmonary bypass resuscitation on cardiac arrest induced lactic acidosis in dogs.
Topics: Acidosis, Lactic; Animals; Cardiopulmonary Bypass; Dogs; Heart Arrest; Lactates; Lactic Acid; Oxygen | 1989 |
[Significance of lactate analysis in clinical tests].
Topics: Acidosis, Lactic; Diabetes Mellitus; Heart Diseases; Humans; Lactates; Lactic Acid; Liver Diseases; | 1989 |
Effects of in vivo and in vitro production of lactic acid on ionized, protein-bound, and complex-bound calcium in blood.
Topics: Acidosis, Lactic; Calcium; Calcium-Binding Proteins; Exercise; Humans; Hydrogen-Ion Concentration; I | 1989 |
[Continuous pH registration in the coronary sinus in vivo in ischemic and normoxic lactic acidosis using an ion sensitive field effect transistor catheter].
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Animals; Blood Gas Analysis; Cardiac Catheterization; Coron | 1989 |
Renal responses to exercise-induced lactic acidosis.
Topics: Acidosis, Lactic; Adult; Bicarbonates; Chlorides; Exercise; Glomerular Filtration Rate; Humans; Hydr | 1989 |
D-lactate-associated encephalopathy after massive small-bowel resection.
Topics: Acidosis, Lactic; Adolescent; Brain Diseases; Humans; Ileum; Intestinal Absorption; Isomerism; Jejun | 1989 |
Influence of in vitro lactic acidosis on central nervous system neurons.
Topics: Acidosis, Lactic; Brain Diseases; Cells, Cultured; Central Nervous System; Chromatin; Citrates; Citr | 1989 |
Effects of sodium dichloroacetate dose. Brain metabolites associated with cerebral ischemia.
Topics: Acetates; Acidosis, Lactic; Animals; Brain Chemistry; Brain Ischemia; Dichloroacetic Acid; Disease M | 1989 |
[Comparative effects of dichloroacetate and sodium bicarbonate on plasma lactic acid levels in experimentally produced hypoxia].
Topics: Acetates; Acidosis, Lactic; Animals; Bicarbonates; Dichloroacetic Acid; Dogs; Hemodynamics; Hypoxia; | 1987 |
Improved hemodynamic function during hypoxia with Carbicarb, a new agent for the management of acidosis.
Topics: Acidosis, Lactic; Animals; Bicarbonates; Blood Gas Analysis; Carbonates; Cardiac Output; Dogs; Drug | 1988 |
[MELAS (mitochondrial encephalopathy, lactic acidosis and stroke-like episodes): report of a case].
Topics: Acidosis, Lactic; Brain Diseases; Cerebrovascular Disorders; Child; Electron Transport Complex IV; H | 1987 |
Mitochondrial myopathy with lactic acidaemia, Fanconi-De Toni-Debré syndrome and a disturbed succinate: cytochrome c oxidoreductase activity.
Topics: Acidosis, Lactic; Carnitine; Fanconi Syndrome; Female; Humans; Infant, Newborn; Lactates; Lactic Aci | 1988 |
[The diagnosis and therapy of lactic acidosis].
Topics: Acidosis, Lactic; Bicarbonates; Humans; Lactates; Lactic Acid; Male; Middle Aged; Sodium; Sodium Bic | 1988 |
Effect of dichloroacetate in the treatment of anoxic lactic acidosis in dogs.
Topics: Acetates; Acidosis, Lactic; Animals; Bicarbonates; Carbon Dioxide; Dichloroacetic Acid; Dogs; Heart | 1986 |
Bicarbonate therapy for organic acidosis: the case for its continued use.
Topics: Acidosis, Lactic; Animals; Bicarbonates; Carbon Dioxide; Hemodynamics; Humans; Hydrogen-Ion Concentr | 1987 |
Deficiency of the reduced nicotinamide adenine dinucleotide dehydrogenase component of complex I of mitochondrial electron transport. Fatal infantile lactic acidosis and hypermetabolism with skeletal-cardiac myopathy and encephalopathy.
Topics: Acidosis, Lactic; Bone and Bones; Brain; Electron Transport; Energy Metabolism; Humans; Infant, Newb | 1987 |
Role of brain lactic acidosis in hypoxic depression of respiration.
Topics: Acidosis, Lactic; Animals; Brain; Carbon Monoxide; Cats; Chemoreceptor Cells; Denervation; Dichloroa | 1988 |
Ruminal lactic acidosis: forestomach epithelial receptor activation by undissociated volatile fatty acids and rumen fluids collected during loss of reticuloruminal motility.
Topics: Acetates; Acetic Acid; Acidosis, Lactic; Animals; Butyrates; Butyric Acid; Fatty Acids, Volatile; La | 1988 |
Effects of the ionophores monensin and tetronasin on simulated development of ruminal lactic acidosis in vitro.
Topics: Acidosis, Lactic; Animals; Cattle; Furans; Glucose; Hydrogen-Ion Concentration; In Vitro Techniques; | 1988 |
Electrolyte case vignette: a case of unusual organic acidosis.
Topics: Acid-Base Equilibrium; Acidosis; Acidosis, Lactic; Adult; Diagnosis, Differential; Humans; Ketosis; | 1988 |
Lactic acidosis and recovery of neuronal function following cerebral hypoxia in vitro.
Topics: Acidosis, Lactic; Action Potentials; Animals; Hippocampus; In Vitro Techniques; Lactates; Lactic Aci | 1988 |
Hyperlactataemia and metabolic acidosis following paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Adolescent; Adult; Aged; Aged, 80 and over; Female; | 1987 |
[Effect of dichloroacetate on plasma lactic acid in experimentally produced hypoxia].
Topics: Acetates; Acidosis, Lactic; Animals; Dichloroacetic Acid; Dogs; Hemodynamics; Hypoxia; Lactates; Lac | 1986 |
Convulsions as the etiology of lactic acidosis in acute diazinon toxicity in rats.
Topics: Acidosis, Lactic; Acute Disease; Animals; Diazinon; Female; Glycogen; Insecticides; Lactates; Lactic | 1987 |
Metabolic acidosis not due to lactic acidosis in patients with severe acute asthma.
Topics: Acid-Base Equilibrium; Acidosis; Acidosis, Lactic; Adolescent; Adult; Aged; Asthma; Bicarbonates; Bl | 1987 |
Lactic acidosis during closed-chest CPR in dogs.
Topics: Acidosis, Lactic; Animals; Arteries; Blood Pressure; Dogs; Electric Countershock; Lactates; Lactic A | 1987 |
Mitochondrial acetoacetyl-CoA thiolase deficiency.
Topics: Acetyl-CoA C-Acyltransferase; Acidosis, Lactic; Acyltransferases; Carboxylic Acids; Child, Preschool | 1986 |
Renal effects of dichloroacetate in vivo.
Topics: Acetates; Acidosis, Lactic; Administration, Oral; Child, Preschool; Dichloroacetic Acid; Gas Chromat | 1986 |
Delayed lactate clearance in patients surviving circulatory shock.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Female; Humans; Lactates; Lactic Acid; Male; Middle Aged; | 1985 |