lactic acid has been researched along with ALS - Amyotrophic Lateral Sclerosis in 19 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the efficacy of curcumin oral supplementation (600 mg/day, Brainoil), a natural antioxidant compound, in Amyotrophic Lateral Sclerosis (ALS)." | 9.27 | Amyotrophic Lateral Sclerosis and Oxidative Stress: A Double-Blind Therapeutic Trial After Curcumin Supplementation. ( Bisordi, C; Chico, L; Ienco, EC; Lo Gerfo, A; Mancuso, M; Petrozzi, L; Petrucci, A; Siciliano, G, 2018) |
| "In this study, we aim to verify whether swim training can improve lactate metabolism, NAD+ and NADH levels, as well as modify the activity of glycolytic and NADH shuttle enzymes and monocarboxylate transporters (MCTs) in skeletal muscle of amyotrophic lateral sclerosis (ALS) mice." | 8.12 | Swim Training Affects on Muscle Lactate Metabolism, Nicotinamide Adenine Dinucleotides Concentration, and the Activity of NADH Shuttle Enzymes in a Mouse Model of Amyotrophic Lateral Sclerosis. ( Antosiewicz, J; Cieminski, K; Dzik, KP; Flis, DJ; Kaczor, JJ; Wieckowski, MR; Ziolkowski, W, 2022) |
| "To investigate the efficacy of curcumin oral supplementation (600 mg/day, Brainoil), a natural antioxidant compound, in Amyotrophic Lateral Sclerosis (ALS)." | 5.27 | Amyotrophic Lateral Sclerosis and Oxidative Stress: A Double-Blind Therapeutic Trial After Curcumin Supplementation. ( Bisordi, C; Chico, L; Ienco, EC; Lo Gerfo, A; Mancuso, M; Petrozzi, L; Petrucci, A; Siciliano, G, 2018) |
| "In this study, we aim to verify whether swim training can improve lactate metabolism, NAD+ and NADH levels, as well as modify the activity of glycolytic and NADH shuttle enzymes and monocarboxylate transporters (MCTs) in skeletal muscle of amyotrophic lateral sclerosis (ALS) mice." | 4.12 | Swim Training Affects on Muscle Lactate Metabolism, Nicotinamide Adenine Dinucleotides Concentration, and the Activity of NADH Shuttle Enzymes in a Mouse Model of Amyotrophic Lateral Sclerosis. ( Antosiewicz, J; Cieminski, K; Dzik, KP; Flis, DJ; Kaczor, JJ; Wieckowski, MR; Ziolkowski, W, 2022) |
| "Amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease) is a progressive debilitating neurodegenerative disease with no cure." | 2.48 | Lactate dyscrasia: a novel explanation for amyotrophic lateral sclerosis. ( Atwood, CS; Vadakkadath Meethal, S, 2012) |
| "To assess how often mitochondrial myopathy (MMP) mimics amyotrophic lateral sclerosis (ALS) and the phenotypic similarities and differences between these two disorders." | 1.31 | Mitochondriopathy as a differential diagnosis of amyotrophic lateral sclerosis. ( Finsterer, J, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.53) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 11 (57.89) | 24.3611 |
| 2020's | 3 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Bøgh, N | 1 |
| Laustsen, C | 1 |
| Hansen, ESS | 1 |
| Tankisi, H | 1 |
| Bertelsen, LB | 1 |
| Blicher, JU | 1 |
| Cieminski, K | 1 |
| Flis, DJ | 1 |
| Dzik, KP | 1 |
| Kaczor, JJ | 1 |
| Wieckowski, MR | 1 |
| Antosiewicz, J | 1 |
| Ziolkowski, W | 1 |
| Vandoorne, T | 1 |
| Veys, K | 1 |
| Guo, W | 1 |
| Sicart, A | 1 |
| Vints, K | 1 |
| Swijsen, A | 1 |
| Moisse, M | 1 |
| Eelen, G | 1 |
| Gounko, NV | 1 |
| Fumagalli, L | 1 |
| Fazal, R | 1 |
| Germeys, C | 1 |
| Quaegebeur, A | 1 |
| Fendt, SM | 1 |
| Carmeliet, P | 1 |
| Verfaillie, C | 1 |
| Van Damme, P | 1 |
| Ghesquière, B | 1 |
| De Bock, K | 1 |
| Van Den Bosch, L | 1 |
| Gyawali, A | 1 |
| Kang, YS | 1 |
| Lanfranconi, F | 1 |
| Ferri, A | 1 |
| Corna, G | 1 |
| Bonazzi, R | 1 |
| Lunetta, C | 1 |
| Silani, V | 1 |
| Riva, N | 1 |
| Rigamonti, A | 1 |
| Maggiani, A | 1 |
| Ferrarese, C | 1 |
| Tremolizzo, L | 1 |
| Yang, LP | 1 |
| Fan, DS | 2 |
| Chico, L | 1 |
| Ienco, EC | 1 |
| Bisordi, C | 1 |
| Lo Gerfo, A | 1 |
| Petrozzi, L | 1 |
| Petrucci, A | 1 |
| Mancuso, M | 1 |
| Siciliano, G | 3 |
| Gray, E | 1 |
| Larkin, JR | 1 |
| Claridge, TD | 1 |
| Talbot, K | 1 |
| Sibson, NR | 1 |
| Turner, MR | 1 |
| Zhang, YJ | 1 |
| Ferraiuolo, L | 2 |
| Meyer, K | 1 |
| Sherwood, TW | 1 |
| Vick, J | 1 |
| Likhite, S | 1 |
| Frakes, A | 1 |
| Miranda, CJ | 1 |
| Braun, L | 1 |
| Heath, PR | 2 |
| Pineda, R | 1 |
| Beattie, CE | 1 |
| Shaw, PJ | 2 |
| Askwith, CC | 1 |
| McTigue, D | 1 |
| Kaspar, BK | 1 |
| Pradat, PF | 1 |
| Bruneteau, G | 1 |
| Gordon, PH | 1 |
| Dupuis, L | 1 |
| Bonnefont-Rousselot, D | 1 |
| Simon, D | 1 |
| Salachas, F | 1 |
| Corcia, P | 1 |
| Frochot, V | 1 |
| Lacorte, JM | 1 |
| Jardel, C | 1 |
| Coussieu, C | 1 |
| Le Forestier, N | 1 |
| Lacomblez, L | 1 |
| Loeffler, JP | 1 |
| Meininger, V | 1 |
| Vadakkadath Meethal, S | 1 |
| Atwood, CS | 1 |
| Higginbottom, A | 1 |
| Barber, S | 1 |
| Greenald, D | 1 |
| Kirby, J | 1 |
| Lee, Y | 1 |
| Morrison, BM | 1 |
| Li, Y | 1 |
| Lengacher, S | 1 |
| Farah, MH | 1 |
| Hoffman, PN | 1 |
| Liu, Y | 1 |
| Tsingalia, A | 1 |
| Jin, L | 1 |
| Zhang, PW | 1 |
| Pellerin, L | 1 |
| Magistretti, PJ | 1 |
| Rothstein, JD | 1 |
| D'Avino, C | 1 |
| Del Corona, A | 1 |
| Barsacchi, R | 1 |
| Kusmic, C | 1 |
| Rocchi, A | 1 |
| Pastorini, E | 2 |
| Murri, L | 2 |
| Finsterer, J | 1 |
| Pasquali, L | 1 |
| Manca, ML | 1 |
| Iudice, A | 1 |
| Yase, Y | 1 |
| Sanjak, M | 1 |
| Paulson, D | 1 |
| Sufit, R | 1 |
| Reddan, W | 1 |
| Beaulieu, D | 1 |
| Erickson, L | 1 |
| Shug, A | 1 |
| Brooks, BR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of Moderate Aerobic Exercise as Determined by Cardiopulmonary Exercise Testing in ALS[NCT03326622] | 48 participants (Actual) | Interventional | 2013-07-01 | Completed | |||
| Impact of the Combined Treatment of Curcumin and Resveratrol Liposomed Polyphenols With G04CB02 on the Clinical Improvement of ALS Patients[NCT04654689] | Phase 2 | 90 participants (Actual) | Interventional | 2021-11-20 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for lactic acid and ALS - Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Lactate dyscrasia: a novel explanation for amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Humans; Lactic Acid; Mitochondrial Diseases; Nerve Degenerat | 2012 |
3 trials available for lactic acid and ALS - Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Amyotrophic Lateral Sclerosis and Oxidative Stress: A Double-Blind Therapeutic Trial After Curcumin Supplementation.
Topics: Advanced Oxidation Protein Products; Aged; Amyotrophic Lateral Sclerosis; Anti-Inflammatory Agents, | 2018 |
Impaired oxidative metabolism and lipid peroxidation in exercising muscle from ALS patients.
Topics: Aged; Amyotrophic Lateral Sclerosis; Biopsy; Exercise Test; Female; Humans; Lactic Acid; Lipid Perox | 2002 |
Impaired oxidative metabolism in exercising muscle from ALS patients.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Electromyography; Exercise Test; Female; Heart Rate; Hum | 2001 |
15 other studies available for lactic acid and ALS - Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Imaging Neurodegenerative Metabolism in Amyotrophic Lateral Sclerosis with Hyperpolarized [1-
Topics: Amyotrophic Lateral Sclerosis; Bicarbonates; Humans; Lactic Acid; Magnetic Resonance Imaging; Neurod | 2022 |
Swim Training Affects on Muscle Lactate Metabolism, Nicotinamide Adenine Dinucleotides Concentration, and the Activity of NADH Shuttle Enzymes in a Mouse Model of Amyotrophic Lateral Sclerosis.
Topics: Adenine; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Lactic Acid; Malate Dehydro | 2022 |
Differentiation but not ALS mutations in FUS rewires motor neuron metabolism.
Topics: Amyotrophic Lateral Sclerosis; Case-Control Studies; Cell Differentiation; Cell Respiration; Glucose | 2019 |
Transport Alteration of 4-Phenyl Butyric Acid Mediated by a Sodium- and Proton-Coupled Monocarboxylic Acid Transporter System in ALS Model Cell Lines (NSC-34) Under Inflammatory States.
Topics: Amyotrophic Lateral Sclerosis; Butyrates; Cell Line; Humans; Hydrogen Peroxide; Lactic Acid; Monocar | 2021 |
Inefficient skeletal muscle oxidative function flanks impaired motor neuron recruitment in Amyotrophic Lateral Sclerosis during exercise.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Exercise; Exercise Test; Female; Humans; Lactic Acid; Ma | 2017 |
Diets for Patients with Amyotrophic Lateral Sclerosis: Pay Attention to Nutritional Intervention.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antioxidants; Diet, Ketogenic; Female; Humans; Lactic Acid; | 2017 |
The longitudinal cerebrospinal fluid metabolomic profile of amyotrophic lateral sclerosis.
Topics: Aged; Amyotrophic Lateral Sclerosis; Biomarkers; Case-Control Studies; Citric Acid; Cohort Studies; | 2015 |
Elimination Rate of Serum Lactate is Correlated with Amyotrophic Lateral Sclerosis Progression.
Topics: Adult; Amyotrophic Lateral Sclerosis; Analysis of Variance; Disease Progression; Female; Humans; Kap | 2016 |
Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism.
Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Biomarkers; C9orf72 Protein; Cell Communication; | 2016 |
Impaired glucose tolerance in patients with amyotrophic lateral sclerosis.
Topics: Adiponectin; Adolescent; Adult; Aged; Amyotrophic Lateral Sclerosis; Blood Glucose; Fatty Acids, Non | 2010 |
Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Cell Communication; Cell Death; Cells, Cultured; | 2011 |
Oligodendroglia metabolically support axons and contribute to neurodegeneration.
Topics: Amyotrophic Lateral Sclerosis; Animals; Axons; Cell Line; Cell Survival; Disease Models, Animal; Dow | 2012 |
Mitochondriopathy as a differential diagnosis of amyotrophic lateral sclerosis.
Topics: Action Potentials; Adult; Aged; Amyotrophic Lateral Sclerosis; Diagnosis, Differential; Electromyogr | 2002 |
The pathogenetic role of metals in motor neuron disease--the participation of aluminum.
Topics: Amyotrophic Lateral Sclerosis; Animals; Anterior Horn Cells; Calcium; Central Nervous System; Guam; | 1987 |
Physiologic and metabolic response to progressive and prolonged exercise in amyotrophic lateral sclerosis.
Topics: 3-Hydroxybutyric Acid; Amyotrophic Lateral Sclerosis; Carnitine; Exercise Test; Fatty Acids, Noneste | 1987 |