lacosamide and Essential-Tremor

lacosamide has been researched along with Essential-Tremor* in 2 studies

Trials

1 trial(s) available for lacosamide and Essential-Tremor

Article	Year
Lacosamide, another therapeutic failure in essential tremor: an open-label trial. Movement disorders : official journal of the Movement Disorder Society, 2011, Volume: 26, Issue:1 Topics: Acetamides; Aged; Disability Evaluation; Essential Tremor; Female; Humans; Lacosamide; Male; Middle Aged; Severity of Illness Index; Statistics, Nonparametric; Time Factors; Treatment Failure	2011

Other Studies

1 other study(ies) available for lacosamide and Essential-Tremor

Article	Year
Lacosamide, the new anticonvulsant, effectively reduces harmaline-induced tremors in rats. European journal of pharmacology, 2008, Jul-28, Volume: 589, Issue:1-3 The present study aimed at evaluating the efficacy of lacosamide (0.3 to 30 mg/kg), a new anticonvulsant drug, in a model of essential tremor in comparison to the reference compounds propranolol and primidone. We observed a high tremorlytic effect of lacosamide reducing the intensity of tremors following harmaline administration in a dose-dependent manner. The highest dose also modified the latency and intensity of tremor at onset. The effect of lacosamide was equal or even superior to propranolol and primidone indicating that lacosamide may be a new antitremorgenic drug that merits further clinical investigation. Topics: Acetamides; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Essential Tremor; Harmaline; Lacosamide; Male; Primidone; Propranolol; Rats; Rats, Sprague-Dawley; Reaction Time	2008

Article

Year

Lacosamide, the new anticonvulsant, effectively reduces harmaline-induced tremors in rats.

European journal of pharmacology, 2008, Jul-28, Volume: 589, Issue:1-3

The present study aimed at evaluating the efficacy of lacosamide (0.3 to 30 mg/kg), a new anticonvulsant drug, in a model of essential tremor in comparison to the reference compounds propranolol and primidone. We observed a high tremorlytic effect of lacosamide reducing the intensity of tremors following harmaline administration in a dose-dependent manner. The highest dose also modified the latency and intensity of tremor at onset. The effect of lacosamide was equal or even superior to propranolol and primidone indicating that lacosamide may be a new antitremorgenic drug that merits further clinical investigation.

Topics: Acetamides; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Essential Tremor; Harmaline; Lacosamide; Male; Primidone; Propranolol; Rats; Rats, Sprague-Dawley; Reaction Time

2008