labetalol has been researched along with Preterm Birth in 7 studies
Labetalol: A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.
labetalol : A diastereoisomeric mixture of approximately equal amounts of all four possible stereoisomers ((R,S)-labetolol, (S,R)-labetolol, (S,S)-labetalol and (R,R)-labetalol). It is an adrenergic antagonist used to treat high blood pressure.
2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide : A member of the class of benzamides that is benzamide substituted by a hydroxy group at position 2 and by a 1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A total of 150 consecutive pregnant women without proteinuria and with physician-recorded systolic BP of 140-160 mmHg and/or diastolic BP of 90-105 mmHg on two occasions ≥6 h apart between 20 and 38 weeks of gestation were randomly allocated to receive either labetalol or methyldopa (50 patients each) plus standard care (treatment group) or only standard care (50 patients) (control group)." | 9.16 | Role of antihypertensive therapy in mild to moderate pregnancy-induced hypertension: a prospective randomized study comparing labetalol with alpha methyldopa. ( Jabeen, F; Malik, AR; Mir, S; Molvi, SN; Rana, VS, 2012) |
| "A total of 150 consecutive pregnant women without proteinuria and with physician-recorded systolic BP of 140-160 mmHg and/or diastolic BP of 90-105 mmHg on two occasions ≥6 h apart between 20 and 38 weeks of gestation were randomly allocated to receive either labetalol or methyldopa (50 patients each) plus standard care (treatment group) or only standard care (50 patients) (control group)." | 5.16 | Role of antihypertensive therapy in mild to moderate pregnancy-induced hypertension: a prospective randomized study comparing labetalol with alpha methyldopa. ( Jabeen, F; Malik, AR; Mir, S; Molvi, SN; Rana, VS, 2012) |
| "Preeclampsia is characterized by blood pressure greater than 140/90 mmHg in the second half of pregnancy." | 2.55 | Pathophysiology and Current Clinical Management of Preeclampsia. ( Amaral, LM; LaMarca, B; Owens, M; Wallace, K, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Dublin, S | 1 |
| Idu, A | 1 |
| Avalos, LA | 1 |
| Cheetham, TC | 1 |
| Easterling, TR | 1 |
| Chen, L | 1 |
| Holt, VL | 1 |
| Nance, N | 1 |
| Bider-Canfield, Z | 1 |
| Neugebauer, RS | 1 |
| Reynolds, K | 1 |
| Badon, SE | 1 |
| Shortreed, SM | 1 |
| Magee, LA | 2 |
| Singer, J | 2 |
| Lee, T | 2 |
| McManus, RJ | 1 |
| Lay-Flurrie, S | 1 |
| Rey, E | 2 |
| Chappell, LC | 1 |
| Myers, J | 1 |
| Logan, AG | 2 |
| von Dadelszen, P | 2 |
| Fitton, CA | 1 |
| Steiner, MFC | 1 |
| Aucott, L | 1 |
| Pell, JP | 1 |
| Mackay, DF | 1 |
| Fleming, M | 1 |
| McLay, JS | 1 |
| Amaral, LM | 1 |
| Wallace, K | 1 |
| Owens, M | 1 |
| LaMarca, B | 1 |
| Chattopadhyay, S | 1 |
| Das, A | 1 |
| Pahari, S | 1 |
| Ross, S | 1 |
| Asztalos, E | 1 |
| Murphy, KE | 1 |
| Menzies, J | 1 |
| Sanchez, J | 1 |
| Gafni, A | 1 |
| Gruslin, A | 1 |
| Helewa, M | 1 |
| Hutton, E | 1 |
| Koren, G | 1 |
| Lee, SK | 1 |
| Ganzevoort, JW | 1 |
| Welch, R | 1 |
| Thornton, JG | 1 |
| Moutquin, JM | 1 |
| Molvi, SN | 1 |
| Mir, S | 1 |
| Rana, VS | 1 |
| Jabeen, F | 1 |
| Malik, AR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The CHIPS Trial (Control of Hypertension In Pregnancy Study)[NCT01192412] | 987 participants (Actual) | Interventional | 2009-04-30 | Completed | |||
| Use of Meditation as a Complementary Therapy in the Treatment of Gestational Hypertension[NCT03873194] | 47 participants (Actual) | Interventional | 2019-04-15 | Completed | |||
| The Effect of Prophylactic Magnesium Use in Pregnant Women on Reversal of Neuromuscular Block With Sugammadex:Evaluation With TOF[NCT05558969] | 30 participants (Anticipated) | Interventional | 2022-09-28 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Pregnancy loss or NICU admission for greater than 48 hours, as recorded in the maternal and infant medical records immediately following the birth (or pregnancy loss), and then again after the mothers' and infants' discharge home. Supplemental information, about potential post-discharge maternal or neonatal morbidities in the 6 weeks following birth for the mother, or 28 days of life for the baby, will be obtained by contacting women at 6 weeks postpartum and/or from medical records. (NCT01192412)
Timeframe: 6 weeks
| Intervention | participants (Number) |
|---|---|
| 'Less Tight' Control. | 155 |
| 'Tight' Control. | 150 |
"Serious maternal complications measured up to 6 weeks postpartum. Death or one or more life-threatening maternal complications:~Adverse neurological complications (stroke, eclampsia, and/or blindness), and/or~End-organ failure (uncontrolled hypertension, inotropic support, pulmonary oedema, respiratory failure, myocardial ischaemia/infarction, renal failure, coagulopathy, and/or transfusion)" (NCT01192412)
Timeframe: 6 weeks
| Intervention | participants (Number) |
|---|---|
| 'Less Tight' Control. | 18 |
| 'Tight' Control. | 10 |
2 reviews available for labetalol and Preterm Birth
| Article | Year |
|---|---|
In-utero exposure to antihypertensive medication and neonatal and child health outcomes: a systematic review.
Topics: Antihypertensive Agents; Attention Deficit Disorder with Hyperactivity; Birth Weight; Child; Child H | 2017 |
Pathophysiology and Current Clinical Management of Preeclampsia.
Topics: Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Delivery, Obstetric; Endothelium, | 2017 |
4 trials available for labetalol and Preterm Birth
| Article | Year |
|---|---|
Are blood pressure level and variability related to pregnancy outcome? Analysis of control of hypertension in pregnancy study data.
Topics: Adult; Antihypertensive Agents; Birth Weight; Female; Humans; Hypertension; Hypertension, Pregnancy- | 2020 |
Fetomaternal outcome in severe preeclamptic women undergoing emergency cesarean section under either general or spinal anesthesia.
Topics: Adolescent; Adult; Anesthesia, General; Anesthesia, Spinal; Anticonvulsants; Antihypertensive Agents | 2014 |
Control of Hypertension In Pregnancy Study randomised controlled trial-are the results dependent on the choice of labetalol or methyldopa?
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Decision-Making; Female; Humans; Hypertensi | 2016 |
Role of antihypertensive therapy in mild to moderate pregnancy-induced hypertension: a prospective randomized study comparing labetalol with alpha methyldopa.
Topics: Adult; Antihypertensive Agents; Cesarean Section; Female; Humans; Hypertension, Pregnancy-Induced; I | 2012 |
1 other study available for labetalol and Preterm Birth
| Article | Year |
|---|---|
Maternal and neonatal outcomes of antihypertensive treatment in pregnancy: A retrospective cohort study.
Topics: Antihypertensive Agents; Birth Weight; Female; Humans; Hypertension, Pregnancy-Induced; Infant; Infa | 2022 |