labetalol has been researched along with Muscle Contraction in 15 studies
Labetalol: A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.
labetalol : A diastereoisomeric mixture of approximately equal amounts of all four possible stereoisomers ((R,S)-labetolol, (S,R)-labetolol, (S,S)-labetalol and (R,R)-labetalol). It is an adrenergic antagonist used to treat high blood pressure.
2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide : A member of the class of benzamides that is benzamide substituted by a hydroxy group at position 2 and by a 1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl group at position 5.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "2." | 5.26 | Effects of the beta-receptor antagonists propranolol, oxprenolol and labetalol on human vascular smooth-muscle contraction. ( Hobson, JD; Jauernig, RA; Moulds, RF; Shaw, J, 1978) |
| "Eleven patients with essential hypertension participated in a double-blind cross-over comparison of labetalol (L) and propranolol (P)." | 5.05 | Effects of labetalol and propranolol on the peripheral circulation in hypertensive patients. ( Berglund, G; Nyberg, G, 1982) |
| "Labetalol was 6-10 times less potent than phentolamine in blocking alpha-adrenoreceptors and 1." | 2.35 | A review of the animal pharmacology of labetalol, a combined alpha- and beta-adrenoceptor-blocking drug. ( Brittain, RT; Levy, GP, 1976) |
| "4 X 10(-6) M) produced parallel shifts to the right of the dose-response curves to noradrenaline and oxymetazoline in isolated strips of cat splenic capsule." | 1.26 | The effects of labetalol (AH 5158) on adrenergic transmission in the cat spleen. ( Blakeley, AG; Summers, RJ, 1977) |
| "2." | 1.26 | Effects of the beta-receptor antagonists propranolol, oxprenolol and labetalol on human vascular smooth-muscle contraction. ( Hobson, JD; Jauernig, RA; Moulds, RF; Shaw, J, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (80.00) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thulesius, O | 1 |
| Gjöres, JE | 1 |
| Berlin, E | 1 |
| Nakagawa, Y | 1 |
| Shimamoto, N | 1 |
| Nakazawa, M | 1 |
| Imai, S | 1 |
| Brittain, RT | 2 |
| Drew, GM | 1 |
| Levy, GP | 2 |
| Nyberg, G | 1 |
| Berglund, G | 1 |
| Huang, YC | 1 |
| Wu, BN | 1 |
| Lin, YT | 1 |
| Chen, SJ | 1 |
| Chiu, CC | 1 |
| Cheng, CJ | 1 |
| Chen, IJ | 1 |
| Blakeley, AG | 1 |
| Summers, RJ | 1 |
| Doggrell, SA | 3 |
| Paton, DM | 2 |
| Moulds, RF | 1 |
| Jauernig, RA | 1 |
| Hobson, JD | 1 |
| Shaw, J | 1 |
| Shiraishi, K | 1 |
| Moriya, M | 1 |
| Miyake, N | 1 |
| Takayanagi, I | 2 |
| Opie, LH | 1 |
| Kameda, H | 1 |
| Monma, Y | 1 |
| Tanabe, T | 1 |
| Kizawa, Y | 1 |
| Iwasaki, S | 1 |
| Nakagoshi, A | 1 |
1 review available for labetalol and Muscle Contraction
| Article | Year |
|---|---|
A review of the animal pharmacology of labetalol, a combined alpha- and beta-adrenoceptor-blocking drug.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Autonomic Fibers, Preganglionic; | 1976 |
1 trial available for labetalol and Muscle Contraction
| Article | Year |
|---|---|
Effects of labetalol and propranolol on the peripheral circulation in hypertensive patients.
Topics: Adult; Aged; Blood Pressure; Double-Blind Method; Ethanolamines; Extremities; Female; Humans; Hypert | 1982 |
13 other studies available for labetalol and Muscle Contraction
| Article | Year |
|---|---|
Alpha- and beta-adrenoceptor blockade by labetalol in human isolated arteries and veins.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Arteries; Ethanolamines; Guinea | 1980 |
Alpha- and beta-blocking activities of racemates of labetalol.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Aorta; Ethanolamines; Guinea Pig | 1980 |
The alpha- and beta-adrenoceptor blocking potencies of labetalol and its individual stereoisomers in anaesthetized dogs and in isolated tissues.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthesia; Animals; Aorta, Thoracic; Dog | 1982 |
Eugenodilol: a third-generation beta-adrenoceptor blocker, derived from eugenol, with alpha-adrenoceptor blocking and beta2-adrenoceptor agonist-associated vasorelaxant activities.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Anesthesia; Animals; Aorta, Thoracic; Bradyca | 1999 |
The effects of labetalol (AH 5158) on adrenergic transmission in the cat spleen.
Topics: Animals; Cats; Drug Interactions; Electric Stimulation; Ethanolamines; In Vitro Techniques; Labetalo | 1977 |
Effect of labetalol and guanethidine on contractile responses to acetylcholine in the rat anococcygeus muscle.
Topics: Acetylcholine; Animals; Ethanolamines; Guanethidine; Hydroxydopamines; In Vitro Techniques; Labetalo | 1978 |
Effects of the beta-receptor antagonists propranolol, oxprenolol and labetalol on human vascular smooth-muscle contraction.
Topics: Adrenergic beta-Antagonists; Arteries; Barium; Dose-Response Relationship, Drug; Humans; In Vitro Te | 1978 |
Release of noradrenaline by labetalol in the rat anococcygeus muscle.
Topics: Animals; Ethanolamines; Hydroxydopamines; In Vitro Techniques; Labetalol; Male; Muscle Contraction; | 1978 |
Alpha 1-adrenoceptor blocking activities of bevantolol hydrochloride(NC-1400) and labetalol in rat isolated thoracic aorta--do they distinguish between subtypes?
Topics: Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Labetalol; Male; Muscle Contraction; Muscle, | 1992 |
The effects of labetalol and dilevalol on isolated cardiovascular preparations of the guinea-pig and rat.
Topics: Animals; Guinea Pigs; Isoproterenol; Labetalol; Male; Muscle Contraction; Muscle, Smooth, Vascular; | 1992 |
Mechanism of smooth muscle contraction: relevance to safety of beta-adrenergic blockade in hypertensive patients with reversible chronic obstructive airways disease.
Topics: Adrenergic beta-Antagonists; Atenolol; Bronchi; Calcium Channel Blockers; Calmodulin; Celiprolol; Cy | 1986 |
A comparison of the beta-adrenoceptor agonist potency of labetalol with those of sympathomimetic drugs, and the role of alpha-receptors in pharmacological actions of these drugs on tracheal smooth muscles in guinea pigs.
Topics: Adrenergic beta-Agonists; Animals; Female; Guinea Pigs; In Vitro Techniques; Labetalol; Male; Muscle | 1986 |
(+/-)-1-[[2-(3,4-Dimethoxphenyl)ethyl]amino]-3-(3-methylphenoxy)-2- propanol hydrochloride (bevantolol, NC-1400) as a beta 1-selective adrenoceptor blocker with alpha 1-adrenoceptor blocking activity.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atenolol; Guinea Pigs; In Vitro | 1987 |