labetalol has been researched along with Disease Models, Animal in 21 studies
Labetalol: A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.
labetalol : A diastereoisomeric mixture of approximately equal amounts of all four possible stereoisomers ((R,S)-labetolol, (S,R)-labetolol, (S,S)-labetalol and (R,R)-labetalol). It is an adrenergic antagonist used to treat high blood pressure.
2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide : A member of the class of benzamides that is benzamide substituted by a hydroxy group at position 2 and by a 1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl group at position 5.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effects of labetalol and pindolol on uterine, placental, and fetal hemodynamics following norepinephrine-induced maternal hypertension in a sheep model of increased placental vascular resistance." | 7.75 | Placental and fetal hemodynamics after labetalol or pindolol in a sheep model of increased placental vascular resistance and maternal hypertension. ( Acharya, G; Alahuhta, S; Erkinaro, T; Haapsamo, M; Kavasmaa, T; Mäkikallio, K; Ohtonen, P; Räsänen, J; Ylikauma, L, 2009) |
| "We investigated the effects of the beta1-beta2-alpha1-blocker, labetalol, in the congestive heart failure (CHF) model induced by aortic constriction in the guinea pig." | 7.71 | Early anti-remodeling effect of labetalol in the congestive heart failure model induced by aortic constriction in the guinea pig. ( Bellissant, E; Goineau, S; Guillo, P; Pape, D; Ramée, MP, 2002) |
| "We investigated the effects of labetalol and pindolol on uterine, placental, and fetal hemodynamics following norepinephrine-induced maternal hypertension in a sheep model of increased placental vascular resistance." | 3.75 | Placental and fetal hemodynamics after labetalol or pindolol in a sheep model of increased placental vascular resistance and maternal hypertension. ( Acharya, G; Alahuhta, S; Erkinaro, T; Haapsamo, M; Kavasmaa, T; Mäkikallio, K; Ohtonen, P; Räsänen, J; Ylikauma, L, 2009) |
| "We investigated the effects of the beta1-beta2-alpha1-blocker, labetalol, in the congestive heart failure (CHF) model induced by aortic constriction in the guinea pig." | 3.71 | Early anti-remodeling effect of labetalol in the congestive heart failure model induced by aortic constriction in the guinea pig. ( Bellissant, E; Goineau, S; Guillo, P; Pape, D; Ramée, MP, 2002) |
| "Patients in cardiac arrest are often taking medications affecting adrenergic activity such as the beta blocker metoprolol and the combined alpha and beta blocker, labetalol." | 1.38 | Beta-blockade causes a reduction in the frequency spectrum of VF but improves resuscitation outcome: A potential limitation of quantitative waveform measures. ( Niemann, J; Rosborough, JP; Shah, AP; Sherman, L; Youngquist, ST, 2012) |
| " Hepatic pharmacokinetic modelling was performed with a two-phase physiologically-based organ pharmacokinetic model with the vascular space and dispersion evaluated with the MID technique." | 1.38 | Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage. ( Crawford, DH; Fletcher, LM; Li, P; Roberts, MS; Robertson, TA; Weiss, M; Zhang, Q, 2012) |
| " Studies were undertaken using an in situ-perfused rat liver and multiple indicator dilution, and outflow data were analyzed with a physiologically based organ pharmacokinetic model." | 1.37 | Hepatic pharmacokinetics of cationic drugs in a high-fat emulsion-induced rat model of nonalcoholic steatohepatitis. ( Crawford, DH; Fletcher, LM; Li, P; Roberts, MS; Robertson, TA; Thorling, CA; Zhang, Q, 2011) |
| "Moxonidine has been shown to be antiarrhythmic during ischaemia in vivo." | 1.30 | Facilitation of spontaneous defibrillation by moxonidine during regional ischaemia in an isolated working rabbit heart model. ( Cobbe, SM; Hicks, MN; Kane, KA; Wolk, R, 1999) |
| "We introduced intracerebral hemorrhage in 12 anesthetized dogs by autologous blood injection under arterial pressure in the deep white matter adjacent to the left caudate region." | 1.30 | Pharmacologic reduction of mean arterial pressure does not adversely affect regional cerebral blood flow and intracranial pressure in experimental intracerebral hemorrhage. ( Hanley, DF; Qureshi, AI; Traystman, RJ; Wilson, DA, 1999) |
| "Carvedilol at a lower dose (7." | 1.30 | Carvedilol and lacidipine prevent cardiac hypertrophy and endothelin-1 gene overexpression after aortic banding. ( Donckier, J; Godfraind, T; Heyndrickx, GR; Kyselovic, J; Massart, PE; Wibo, M, 1999) |
| "Amosulalol was approximately threefold more potent than labetalol and arotinolol in decreasing blood pressure (BP) in conscious SHR." | 1.29 | Characterization of the adrenoceptor antagonistic and antihypertensive activity of oral amosulalol, a combined alpha- and beta-adrenoceptor antagonist, in hypertensive rats. ( Honda, K; Inagaki, O; Nakagawa, C; Shibasaki, M; Sudoh, K, 1994) |
| "Postural hypotension is a common side effect observed in the treatment of hypertension with various drugs." | 1.27 | Evaluation of the risk for drug-induced postural hypotension in an experimental model: investigations with carvedilol, prazosin, labetalol, and guanethidine. ( Bartsch, W; Böhm, E; Hooper, RG; Sponer, G; Strein, K, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (19.05) | 18.7374 |
| 1990's | 6 (28.57) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 7 (33.33) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Li, P | 2 |
| Robertson, TA | 2 |
| Thorling, CA | 1 |
| Zhang, Q | 2 |
| Fletcher, LM | 2 |
| Crawford, DH | 2 |
| Roberts, MS | 2 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Zierath, D | 1 |
| Olmstead, T | 1 |
| Stults, A | 1 |
| Shen, A | 1 |
| Kunze, A | 1 |
| Becker, KJ | 1 |
| Tohda, Y | 1 |
| Furuhashi, T | 1 |
| Sakamoto, K | 1 |
| Erkinaro, T | 1 |
| Kavasmaa, T | 1 |
| Ylikauma, L | 1 |
| Mäkikallio, K | 1 |
| Haapsamo, M | 1 |
| Acharya, G | 1 |
| Ohtonen, P | 1 |
| Alahuhta, S | 1 |
| Räsänen, J | 1 |
| Sherman, L | 1 |
| Niemann, J | 1 |
| Youngquist, ST | 1 |
| Shah, AP | 1 |
| Rosborough, JP | 1 |
| Weiss, M | 1 |
| Scannapieco, G | 1 |
| Pauletto, P | 1 |
| Semplicini, A | 1 |
| Dario, C | 1 |
| Vescovo, G | 1 |
| Mazzucato, A | 1 |
| Angelini, A | 1 |
| Pessina, AC | 1 |
| Pogwizd, SM | 1 |
| Sharma, AD | 1 |
| Corr, PB | 1 |
| Nakagawa, Y | 1 |
| Takeda, K | 1 |
| Sakurai, H | 1 |
| Mitomi, A | 1 |
| Imai, S | 1 |
| Inagaki, O | 1 |
| Sudoh, K | 1 |
| Shibasaki, M | 1 |
| Nakagawa, C | 1 |
| Honda, K | 1 |
| Mertes, PM | 1 |
| el-Abbassi, K | 1 |
| Siaghy, EM | 1 |
| Delophont, P | 1 |
| Michel, C | 1 |
| Longrois-Undergureanu, D | 1 |
| Carteaux, JP | 1 |
| Villemot, JP | 1 |
| Wolk, R | 1 |
| Kane, KA | 1 |
| Cobbe, SM | 1 |
| Hicks, MN | 1 |
| Kochanek, PM | 1 |
| Snyder, JV | 1 |
| Bircher, NG | 1 |
| Qureshi, AI | 1 |
| Wilson, DA | 1 |
| Hanley, DF | 1 |
| Traystman, RJ | 1 |
| Massart, PE | 1 |
| Donckier, J | 1 |
| Kyselovic, J | 1 |
| Godfraind, T | 1 |
| Heyndrickx, GR | 1 |
| Wibo, M | 1 |
| Farhat, F | 1 |
| Loisance, D | 1 |
| Garnier, JP | 1 |
| Kirsch, M | 1 |
| Pape, D | 1 |
| Goineau, S | 1 |
| Guillo, P | 1 |
| Ramée, MP | 1 |
| Bellissant, E | 1 |
| Bartsch, W | 1 |
| Sponer, G | 1 |
| Strein, K | 1 |
| Böhm, E | 1 |
| Hooper, RG | 1 |
2 reviews available for labetalol and Disease Models, Animal
| Article | Year |
|---|---|
[My research on asthma today and in the future].
Topics: Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; D | 2013 |
How low can you go? Blood pressure control after intracranial hemorrhage.
Topics: Animals; Antihypertensive Agents; Basal Ganglia; Blood Pressure; Cerebral Hemorrhage; Cerebrovascula | 1999 |
19 other studies available for labetalol and Disease Models, Animal
| Article | Year |
|---|---|
Hepatic pharmacokinetics of cationic drugs in a high-fat emulsion-induced rat model of nonalcoholic steatohepatitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Cations; Cytochrome P-450 | 2011 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Chemical Sympathectomy, but not Adrenergic Blockade, Improves Stroke Outcome.
Topics: Adrenergic Antagonists; Animals; Behavior, Animal; Brain; C-Reactive Protein; Disease Models, Animal | 2018 |
Regulation of AKT activity prevents autonomic nervous system imbalance.
Topics: Acetates; Adrenergic beta-Antagonists; Animals; Autonomic Nervous System Diseases; Benzopyrans; Dise | 2017 |
Placental and fetal hemodynamics after labetalol or pindolol in a sheep model of increased placental vascular resistance and maternal hypertension.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Anima | 2009 |
Beta-blockade causes a reduction in the frequency spectrum of VF but improves resuscitation outcome: A potential limitation of quantitative waveform measures.
Topics: Adrenergic beta-Antagonists; Animals; Cardiopulmonary Resuscitation; Confidence Intervals; Disease M | 2012 |
Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage.
Topics: Adrenergic Antagonists; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti | 2012 |
[Evaluation of the efficacy of various hypotensive drugs in broad-breasted white turkeys as an experimental model of arterial hypertension with high catecholamine levels].
Topics: Animals; Antihypertensive Agents; Captopril; Catecholamines; Disease Models, Animal; Furosemide; Hyp | 1983 |
Influences of labetalol a combined alpha- and beta-adrenergic blocking agent on the dysrhythmias induced by coronary occlusion and reperfusion.
Topics: Animals; Arrhythmias, Cardiac; Cats; Coronary Disease; Disease Models, Animal; Dose-Response Relatio | 1982 |
[Antihypertensive effects of labetalol in three types of hypertensive models of rats (author's transl)].
Topics: Animals; Blood Pressure; Disease Models, Animal; Ethanolamines; Female; Heart Rate; Hypertension; La | 1981 |
Characterization of the adrenoceptor antagonistic and antihypertensive activity of oral amosulalol, a combined alpha- and beta-adrenoceptor antagonist, in hypertensive rats.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Antihypert | 1994 |
[Protective effect of labetalol on cardiovascular consequences of brain death in the swine].
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Brain Death; Disease Models, Ani | 1997 |
Facilitation of spontaneous defibrillation by moxonidine during regional ischaemia in an isolated working rabbit heart model.
Topics: Action Potentials; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Disease Models, Animal; E | 1999 |
Pharmacologic reduction of mean arterial pressure does not adversely affect regional cerebral blood flow and intracranial pressure in experimental intracerebral hemorrhage.
Topics: Animals; Antihypertensive Agents; Blood Flow Velocity; Blood Pressure; Brain Ischemia; Cerebral Hemo | 1999 |
Carvedilol and lacidipine prevent cardiac hypertrophy and endothelin-1 gene overexpression after aortic banding.
Topics: Actins; Animals; Antihypertensive Agents; Aortic Diseases; Blood Pressure; Carbazoles; Carotid Arter | 1999 |
Norepinephrine release after acute brain death abolishes the cardioprotective effects of ischemic preconditioning in rabbit.
Topics: Animals; Brain Death; Coronary Disease; Disease Models, Animal; Female; Hemodynamics; Ischemic Preco | 2001 |
Early anti-remodeling effect of labetalol in the congestive heart failure model induced by aortic constriction in the guinea pig.
Topics: Adrenergic beta-Antagonists; Animals; Aorta; Aortic Valve Stenosis; Body Weight; Disease Models, Ani | 2002 |
Evaluation of the risk for drug-induced postural hypotension in an experimental model: investigations with carvedilol, prazosin, labetalol, and guanethidine.
Topics: Animals; Blood Pressure; Carbazoles; Carvedilol; Disease Models, Animal; Guanethidine; Hypotension, | 1987 |