labetalol has been researched along with Complication, Postoperative in 34 studies
Labetalol: A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.
labetalol : A diastereoisomeric mixture of approximately equal amounts of all four possible stereoisomers ((R,S)-labetolol, (S,R)-labetolol, (S,S)-labetalol and (R,R)-labetalol). It is an adrenergic antagonist used to treat high blood pressure.
2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide : A member of the class of benzamides that is benzamide substituted by a hydroxy group at position 2 and by a 1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The antihypertensive efficacy and safety of IV labetalol were evaluated and compared with the efficacy and safety of IV hydralazine in the treatment of postoperative hypertension." | 9.06 | Comparative hemodynamic effects of labetalol and hydralazine in the treatment of postoperative hypertension. ( Dimich, I; Gabrielson, G; Kaplan, JA; Lingham, R; Singh, PP, 1989) |
| "Although considering the pathophysiology of post-coarctectomy hypertension, β-blockers should be effective, experience with labetalol for treatment is limited in the literature." | 8.12 | Treatment of Post-Coarctectomy Hypertension With Labetalol-A 9-Year Single-Center Experience. ( Brouwer, CNM; Roeleveld, PP; Siersma, C; Sojak, V; Ten Harkel, ADJ, 2022) |
| "Routine use of preoperative metoprolol, but not atenolol, is associated with stroke after noncardiac surgery, even after adjusting for comorbidities." | 7.79 | Perioperative metoprolol and risk of stroke after noncardiac surgery. ( Freundlich, RE; Kheterpal, S; Mashour, GA; Matlen, L; Merte, J; Nallamothu, BK; Shanks, A; Sharifpour, M; Tremper, KK; Vlisides, PE; Weightman, A, 2013) |
| "Although labetalol (LAB), the combination of an alpha- and beta-adrenergic blocking agent, is thought to be effective and safe for the control of postoperative hypertension, no study has focused on changes in left ventricular (LV) function when this drug was used to control postoperative hypertension." | 7.68 | Transesophageal echocardiographic assessment of left ventricular function in response to labetalol for control of postoperative hypertension. ( Baron, JF; Coriat, P; Gosgnach, M; Le Bret, F; Reiz, S; Viars, P, 1992) |
| "Three renal transplant recipients developed potentially life-threatening hyperkalemia after receiving intravenous labetalol for postoperative hypertension." | 7.68 | Hyperkalemia associated with intravenous labetalol therapy for acute hypertension in renal transplant recipients. ( Arthur, S; Greenberg, A, 1990) |
| "Intravenous labetalol is commonly used in the management of hypertensive emergencies or urgencies as well as postoperative hypertension." | 7.67 | The safety of cumulative doses of labetalol in perioperative hypertension. ( Cosentino, F; Little, JR; Orlowski, JP; Shiesley, D; Vidt, DG, 1989) |
| "Hypertension is common following coronary artery bypass surgery." | 6.66 | Intravenous labetalol versus sodium nitroprusside for treatment of hypertension postcoronary bypass surgery. ( Cruise, CJ; David, TE; Marquez-Julio, A; Skrobik, Y; Webster, RE, 1989) |
| "Both esmolol and labetalol were equally effective in controlling systolic blood pressure on emergence and in the recovery room in patients undergoing intracranial surgery." | 5.28 | Labetalol and esmolol in the control of hypertension after intracranial surgery. ( Black, S; Cucchiara, RF; Losasso, TJ; Muzzi, DA, 1990) |
| "Paradoxical hypertension is a relatively common complication of surgical repair of coarctation of the aorta." | 5.27 | Intravenous labetalol for the control of hypertension following repair of coarctation of the aorta. ( Bojar, RM; Cleveland, RJ; Weiner, B, 1988) |
| "Labetalol is a combined alpha- and beta-adrenoreceptor blocking agent." | 5.27 | Continuous i.v. infusion of labetalol for postoperative hypertension. Haemodynamic effects and plasma kinetics. ( Chauvin, M; Deriaz, H; Viars, P, 1987) |
| "The antihypertensive efficacy and safety of IV labetalol were evaluated and compared with the efficacy and safety of IV hydralazine in the treatment of postoperative hypertension." | 5.06 | Comparative hemodynamic effects of labetalol and hydralazine in the treatment of postoperative hypertension. ( Dimich, I; Gabrielson, G; Kaplan, JA; Lingham, R; Singh, PP, 1989) |
| "Although considering the pathophysiology of post-coarctectomy hypertension, β-blockers should be effective, experience with labetalol for treatment is limited in the literature." | 4.12 | Treatment of Post-Coarctectomy Hypertension With Labetalol-A 9-Year Single-Center Experience. ( Brouwer, CNM; Roeleveld, PP; Siersma, C; Sojak, V; Ten Harkel, ADJ, 2022) |
| "Routine use of preoperative metoprolol, but not atenolol, is associated with stroke after noncardiac surgery, even after adjusting for comorbidities." | 3.79 | Perioperative metoprolol and risk of stroke after noncardiac surgery. ( Freundlich, RE; Kheterpal, S; Mashour, GA; Matlen, L; Merte, J; Nallamothu, BK; Shanks, A; Sharifpour, M; Tremper, KK; Vlisides, PE; Weightman, A, 2013) |
| "We report a case of a large labetalol overdose in an eight-month-old infant that was being treated for hypertension following surgery for coarctation of the aorta." | 3.74 | Severe labetalol overdose in an 8-month-old infant. ( Eiríksson, H; Helgason, H; Johannesdottir, A; Thorsteinsson, A, 2008) |
| "Hypertension develops in most patients after transplantation when immunosuppression is based on cyclosporine and prednisone." | 3.68 | De novo hypertension after liver transplantation. ( Textor, SC, 1993) |
| "Although labetalol (LAB), the combination of an alpha- and beta-adrenergic blocking agent, is thought to be effective and safe for the control of postoperative hypertension, no study has focused on changes in left ventricular (LV) function when this drug was used to control postoperative hypertension." | 3.68 | Transesophageal echocardiographic assessment of left ventricular function in response to labetalol for control of postoperative hypertension. ( Baron, JF; Coriat, P; Gosgnach, M; Le Bret, F; Reiz, S; Viars, P, 1992) |
| "Three renal transplant recipients developed potentially life-threatening hyperkalemia after receiving intravenous labetalol for postoperative hypertension." | 3.68 | Hyperkalemia associated with intravenous labetalol therapy for acute hypertension in renal transplant recipients. ( Arthur, S; Greenberg, A, 1990) |
| "Intravenous labetalol is commonly used in the management of hypertensive emergencies or urgencies as well as postoperative hypertension." | 3.67 | The safety of cumulative doses of labetalol in perioperative hypertension. ( Cosentino, F; Little, JR; Orlowski, JP; Shiesley, D; Vidt, DG, 1989) |
| "Labetalol was well tolerated in this group of patients who had preserved ventricular function." | 2.68 | Effect of antihypertensive agents on the arterial partial pressure of oxygen and venous admixture after cardiac surgery. ( Wood, G, 1997) |
| " Although 28 patients required no further labetalol in the maintenance period, in the others dosage varied from 5 to 400 mg." | 2.67 | Labetalol for the control of elevated blood pressure following coronary artery bypass grafting. ( Goldberg, JS; Klamerus, KJ; Leslie, JB; Levitsky, S; Mann, HJ; Mills, SA; Molina, JE; Prough, DS; Sladen, RN; Swafford, MW, 1990) |
| "Hypertension is common following coronary artery bypass surgery." | 2.66 | Intravenous labetalol versus sodium nitroprusside for treatment of hypertension postcoronary bypass surgery. ( Cruise, CJ; David, TE; Marquez-Julio, A; Skrobik, Y; Webster, RE, 1989) |
| "Perioperative hypertension is commonly encountered in patients that undergo surgery." | 2.44 | Perioperative hypertension management. ( Marik, PE; Varon, J, 2008) |
| "A case of type III aortic dissection which occurred fourteen months after heart transplantation is presented." | 2.40 | Successful management of acute aortic dissection in a heart transplant recipient. ( Bertrand, O; Defraigne, JO; Demoulin, JC; Detry, O; Limet, R, 1997) |
| "Differentiation from acute cerebral ischemia is important in order to prevent permanent vision loss due to delay in initiating prompt and vigorous treatment of exacerbating factors, such as intermittent hypertension." | 1.36 | Postoperative blindness associated with posterior reversible encephalopathy syndrome: a case report. ( Kim, TK; Kim, WS; Lee, HJ; Park, SC; Yoon, JU; Yoon, JY, 2010) |
| "Correction of high grade carotid artery stenosis may result in cerebral hyperperfusion because of defective vascular autoregulation." | 1.29 | Defective cerebrovascular autoregulation after carotid endarterectomy. ( Jørgensen, LG; Schroeder, TV, 1993) |
| "Both esmolol and labetalol were equally effective in controlling systolic blood pressure on emergence and in the recovery room in patients undergoing intracranial surgery." | 1.28 | Labetalol and esmolol in the control of hypertension after intracranial surgery. ( Black, S; Cucchiara, RF; Losasso, TJ; Muzzi, DA, 1990) |
| "Recognition of algodystrophy is important to avoid further vascular surgery which will exacerbate the symptoms." | 1.27 | Algodystrophy after aortic bifurcation surgery. ( Churcher, MD, 1984) |
| "Paradoxical hypertension is a relatively common complication of surgical repair of coarctation of the aorta." | 1.27 | Intravenous labetalol for the control of hypertension following repair of coarctation of the aorta. ( Bojar, RM; Cleveland, RJ; Weiner, B, 1988) |
| "Labetalol is a combined alpha- and beta-adrenoreceptor blocking agent." | 1.27 | Continuous i.v. infusion of labetalol for postoperative hypertension. Haemodynamic effects and plasma kinetics. ( Chauvin, M; Deriaz, H; Viars, P, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (44.12) | 18.7374 |
| 1990's | 13 (38.24) | 18.2507 |
| 2000's | 2 (5.88) | 29.6817 |
| 2010's | 3 (8.82) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Siersma, C | 1 |
| Brouwer, CNM | 1 |
| Sojak, V | 1 |
| Ten Harkel, ADJ | 1 |
| Roeleveld, PP | 1 |
| Mashour, GA | 1 |
| Sharifpour, M | 1 |
| Freundlich, RE | 1 |
| Tremper, KK | 1 |
| Shanks, A | 1 |
| Nallamothu, BK | 1 |
| Vlisides, PE | 1 |
| Weightman, A | 1 |
| Matlen, L | 1 |
| Merte, J | 1 |
| Kheterpal, S | 1 |
| Mondel, PK | 1 |
| Udare, AS | 1 |
| Anand, S | 1 |
| Kulkarni, AV | 1 |
| Kapadia, FN | 1 |
| Modhe, JM | 1 |
| Limaye, US | 1 |
| Varon, J | 1 |
| Marik, PE | 1 |
| Kim, TK | 1 |
| Yoon, JU | 1 |
| Park, SC | 1 |
| Lee, HJ | 1 |
| Kim, WS | 1 |
| Yoon, JY | 1 |
| Gray, RJ | 1 |
| Thorsteinsson, A | 1 |
| Johannesdottir, A | 1 |
| Eiríksson, H | 1 |
| Helgason, H | 1 |
| Churcher, MD | 1 |
| Montolivo, M | 2 |
| Gemma, M | 2 |
| Regi, B | 2 |
| Coffano, B | 1 |
| Giannini, A | 1 |
| Grandi, L | 1 |
| Fiacchino, F | 2 |
| Textor, SC | 1 |
| Jørgensen, LG | 1 |
| Schroeder, TV | 1 |
| Defraigne, JO | 1 |
| Demoulin, JC | 1 |
| Detry, O | 1 |
| Bertrand, O | 1 |
| Limet, R | 1 |
| Wood, G | 1 |
| Le Bret, F | 2 |
| Coriat, P | 2 |
| Gosgnach, M | 1 |
| Baron, JF | 1 |
| Reiz, S | 1 |
| Viars, P | 3 |
| Pastore, JC | 1 |
| Bricchi, M | 1 |
| Vescovi, A | 1 |
| Mutch, WA | 1 |
| Ringaert, KR | 1 |
| Ewert, FJ | 1 |
| White, IW | 1 |
| Donen, N | 1 |
| Hudson, RJ | 1 |
| Muzzi, DA | 1 |
| Black, S | 1 |
| Losasso, TJ | 1 |
| Cucchiara, RF | 1 |
| Malsch, E | 1 |
| Katonah, J | 1 |
| Gratz, I | 1 |
| Scott, A | 1 |
| Sladen, RN | 1 |
| Klamerus, KJ | 1 |
| Swafford, MW | 1 |
| Prough, DS | 1 |
| Mann, HJ | 1 |
| Leslie, JB | 2 |
| Goldberg, JS | 1 |
| Levitsky, S | 1 |
| Molina, JE | 1 |
| Mills, SA | 1 |
| Arthur, S | 1 |
| Greenberg, A | 1 |
| Geniton, DJ | 1 |
| Turki, S | 1 |
| Mouren, S | 1 |
| Arthaud, M | 1 |
| Higgins, TL | 1 |
| Estafanous, FG | 1 |
| Dimich, I | 1 |
| Lingham, R | 1 |
| Gabrielson, G | 1 |
| Singh, PP | 1 |
| Kaplan, JA | 1 |
| Cruise, CJ | 1 |
| Skrobik, Y | 1 |
| Webster, RE | 1 |
| Marquez-Julio, A | 1 |
| David, TE | 1 |
| Inada, E | 1 |
| Cullen, DJ | 1 |
| Nemeskal, AR | 1 |
| Teplick, R | 1 |
| Cosentino, F | 1 |
| Vidt, DG | 2 |
| Orlowski, JP | 2 |
| Shiesley, D | 2 |
| Little, JR | 2 |
| Bojar, RM | 1 |
| Weiner, B | 1 |
| Cleveland, RJ | 1 |
| Prys-Roberts, C | 1 |
| Dagnino, J | 1 |
| Barnett, GH | 1 |
| Saarnivaara, L | 1 |
| Klemola, UM | 1 |
| Lindgren, L | 1 |
| Kalayjian, RW | 1 |
| Sirgo, MA | 1 |
| Plachetka, JR | 1 |
| Watkins, WD | 1 |
| Chauvin, M | 1 |
| Deriaz, H | 1 |
| Carrasco, MS | 1 |
| Iribarren, MJ | 1 |
| Torres, LM | 1 |
| Esteban, J | 1 |
| Cobo, I | 1 |
| De Castro, J | 1 |
| Arroyo, JL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficiency of Intravenous Lidocaine to Reduce Coughing and the Hemodynamic Changes Associated to Tracheal Extubation[NCT03731429] | Phase 4 | 144 participants (Anticipated) | Interventional | 2019-04-05 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for labetalol and Complication, Postoperative
| Article | Year |
|---|---|
Perioperative hypertension management.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Enalaprilat; Fenoldopam; Hemodynamics; Humans; | 2008 |
Postcardiac surgical hypertension.
Topics: Cardiac Surgical Procedures; Heart Rate; Humans; Hypertension; Labetalol; Nitroprusside; Norepinephr | 1988 |
Successful management of acute aortic dissection in a heart transplant recipient.
Topics: Aged; Antihypertensive Agents; Aortic Aneurysm, Thoracic; Aortic Dissection; Clonidine; Heart Transp | 1997 |
8 trials available for labetalol and Complication, Postoperative
| Article | Year |
|---|---|
Effect of antihypertensive agents on the arterial partial pressure of oxygen and venous admixture after cardiac surgery.
Topics: Aged; Antihypertensive Agents; Cardiac Surgical Procedures; Female; Humans; Hypertension; Intensive | 1997 |
Continuous opioid infusions for neurosurgical procedures: a double-blind comparison of alfentanil and fentanyl.
Topics: Adult; Aged; Alfentanil; Anesthesia Recovery Period; Anesthesia, Intravenous; Blood Pressure; Consci | 1991 |
The effectiveness of labetalol in treating postoperative hypertension.
Topics: Adult; Aged; Female; Humans; Hypertension; Incidence; Labetalol; Male; Middle Aged; Postoperative Co | 1991 |
Labetalol for the control of elevated blood pressure following coronary artery bypass grafting.
Topics: Analysis of Variance; Blood Pressure; Cardiac Output; Coronary Artery Bypass; Diastole; Female; Hear | 1990 |
A comparison of the hemodynamic effects of labetalol and sodium nitroprusside in patients undergoing carotid endarterectomy.
Topics: Carotid Artery Diseases; Endarterectomy; Female; Ferricyanides; Hemodynamics; Humans; Hypertension; | 1990 |
Comparative hemodynamic effects of labetalol and hydralazine in the treatment of postoperative hypertension.
Topics: Aged; Female; Hemodynamics; Humans; Hydralazine; Hypertension; Labetalol; Male; Middle Aged; Postope | 1989 |
Intravenous labetalol versus sodium nitroprusside for treatment of hypertension postcoronary bypass surgery.
Topics: Adult; Aged; Coronary Artery Bypass; Ferricyanides; Humans; Hypertension; Infusions, Intravenous; La | 1989 |
Effect of labetalol or lidocaine on the hemodynamic response to intubation: a controlled randomized double-blind study.
Topics: Adult; Aged; Analysis of Variance; Blood Pressure; Double-Blind Method; Female; Heart Rate; Humans; | 1989 |
23 other studies available for labetalol and Complication, Postoperative
| Article | Year |
|---|---|
Treatment of Post-Coarctectomy Hypertension With Labetalol-A 9-Year Single-Center Experience.
Topics: Antihypertensive Agents; Blood Pressure; Child; Humans; Hypertension; Labetalol; Nitroprusside; Post | 2022 |
Perioperative metoprolol and risk of stroke after noncardiac surgery.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Analysis of Variance; Ateno | 2013 |
Cerebral hyperperfusion syndrome after endovascular reconstruction of carotid artery in high-flow carotid-jugular fistula.
Topics: Adult; Angiography, Digital Subtraction; Antihypertensive Agents; Arteriovenous Fistula; Carotid Art | 2014 |
Postoperative blindness associated with posterior reversible encephalopathy syndrome: a case report.
Topics: Adrenergic beta-Antagonists; Adult; Blindness; Brain Diseases; Brain Ischemia; Diagnosis, Differenti | 2010 |
Severe labetalol overdose in an 8-month-old infant.
Topics: Antihypertensive Agents; Aortic Coarctation; Female; Humans; Hypertension; Infant; Labetalol; Medica | 2008 |
Algodystrophy after aortic bifurcation surgery.
Topics: Aged; Aorta; Aortography; Autonomic Nerve Block; Female; Humans; Intermittent Claudication; Labetalo | 1984 |
Labetalol as prophylaxis of cardiovascular instability after cerebral angioma surgery.
Topics: Brain Neoplasms; Epinephrine; Hemangioma; Humans; Hypertension; Labetalol; Norepinephrine; Postopera | 1993 |
De novo hypertension after liver transplantation.
Topics: Adult; Azathioprine; Cyclosporine; Humans; Hypertension; Immunosuppression Therapy; Labetalol; Liver | 1993 |
Defective cerebrovascular autoregulation after carotid endarterectomy.
Topics: Adult; Aged; Blood Flow Velocity; Blood Pressure; Brain; Carbon Dioxide; Carotid Stenosis; Echoencep | 1993 |
Transesophageal echocardiographic assessment of left ventricular function in response to labetalol for control of postoperative hypertension.
Topics: Adult; Aged; Anesthesia, Intravenous; Aorta, Abdominal; Blood Pressure; Cardiac Output; Echocardiogr | 1992 |
[Labetalol in the prophylaxis of postoperative arterial hypertension in surgery of the posterior cranial fossa].
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Cranial Fossa, Posterior; Female; Humans; Hypertension; La | 1992 |
Labetalol and esmolol in the control of hypertension after intracranial surgery.
Topics: Adrenergic beta-Antagonists; Anesthesia, General; Brain; Heart Rate; Humans; Hypertension; Labetalol | 1990 |
Hyperkalemia associated with intravenous labetalol therapy for acute hypertension in renal transplant recipients.
Topics: Adult; Humans; Hyperkalemia; Hypertension; Infusions, Intravenous; Kidney Failure, Chronic; Kidney T | 1990 |
[Treatment of postoperative hypertensive crisis with labetalol: effects on left ventricular function].
Topics: Heart; Heart Ventricles; Humans; Hypertension; Labetalol; Middle Aged; Postoperative Complications | 1989 |
Labetalol: time, experience, and adrenergic blockade.
Topics: Coronary Disease; Humans; Hypertension; Intubation, Intratracheal; Labetalol; Postoperative Complica | 1989 |
The safety of cumulative doses of labetalol in perioperative hypertension.
Topics: Adult; Cerebrovascular Disorders; Female; Heart Rate; Hemodynamics; Humans; Hypertension; Infusions, | 1989 |
Intravenous labetalol for the control of hypertension following repair of coarctation of the aorta.
Topics: Adolescent; Aortic Coarctation; Humans; Hypertension; Infusions, Intravenous; Labetalol; Male; Posto | 1988 |
Continuous i.v. infusion of labetalol for postoperative hypertension.
Topics: Humans; Hypertension; Infusions, Intravenous; Labetalol; Postoperative Complications | 1988 |
Labetalol to control blood pressure after cerebrovascular surgery.
Topics: Adolescent; Adult; Aged; Arteriovenous Malformations; Brain; Female; Humans; Hypertension; Infusions | 1988 |
Labetalol as a hypotensive agent for middle ear microsurgery.
Topics: Acid-Base Equilibrium; Adult; Anesthesia; Blood Pressure; Ear, Middle; Female; Hemostasis; Humans; H | 1987 |
Intravenous labetalol for treatment of postoperative hypertension.
Topics: Adult; Aged; Humans; Hypertension; Injections, Intravenous; Labetalol; Middle Aged; Postoperative Co | 1987 |
Continuous i.v. infusion of labetalol for postoperative hypertension. Haemodynamic effects and plasma kinetics.
Topics: Adult; Aged; Hemodynamics; Humans; Hypertension; Infusions, Intravenous; Labetalol; Middle Aged; Pos | 1987 |
[A new technic for protection in surgical stress].
Topics: Adult; Alfentanil; Ethanolamines; Female; Fentanyl; Humans; Intraoperative Complications; Labetalol; | 1985 |