labetalol has been researched along with Cerebral Ischemia in 12 studies
Labetalol: A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.
labetalol : A diastereoisomeric mixture of approximately equal amounts of all four possible stereoisomers ((R,S)-labetolol, (S,R)-labetolol, (S,S)-labetalol and (R,R)-labetalol). It is an adrenergic antagonist used to treat high blood pressure.
2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide : A member of the class of benzamides that is benzamide substituted by a hydroxy group at position 2 and by a 1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Nicardipine and labetalol are commonly administered for the treatment of acute hypertension following stroke." | 7.91 | Nicardipine Associated Risk of Short-Term Mortality in Critically Ill Patients with Ischemic Stroke. ( Desai, A; Hanni, C; Mohamed, W; Parker, D; Saber, H; Sadeghi, M; Singh, A, 2019) |
| "This study aimed to compare the effects of labetalol, nicardipine, or hydralazine on time to target blood pressure before alteplase administration in patients with acute ischemic stroke." | 7.81 | Time to Blood Pressure Control Before Thrombolytic Therapy in Patients With Acute Ischemic Stroke: Comparison of Labetalol, Nicardipine, and Hydralazine. ( Cortes, J; Hall, AB; McKay, C, 2015) |
| "Evaluate the ease of use and tolerability of labetalol (L) and nicardipine (N) for hypertension management in patients with acute stroke." | 7.74 | A comparison of nicardipine and labetalol for acute hypertension management following stroke. ( Coplin, WM; Janisse, J; Liu-Deryke, X; Norris, G; Parker, D; Rhoney, DH, 2008) |
| " Oral nifedipine is now considered an alternative first-line therapy, along with intravenous hydralazine and labetalol for women presenting with pre-eclampsia." | 4.98 | Focused Update on Pharmacologic Management of Hypertensive Emergencies. ( Broscious, R; Devabhakthuni, S; Noel, ZR; Watson, K, 2018) |
| " Nicardipine and labetalol are commonly administered for the treatment of acute hypertension following stroke." | 3.91 | Nicardipine Associated Risk of Short-Term Mortality in Critically Ill Patients with Ischemic Stroke. ( Desai, A; Hanni, C; Mohamed, W; Parker, D; Saber, H; Sadeghi, M; Singh, A, 2019) |
| "This study aimed to compare the effects of labetalol, nicardipine, or hydralazine on time to target blood pressure before alteplase administration in patients with acute ischemic stroke." | 3.81 | Time to Blood Pressure Control Before Thrombolytic Therapy in Patients With Acute Ischemic Stroke: Comparison of Labetalol, Nicardipine, and Hydralazine. ( Cortes, J; Hall, AB; McKay, C, 2015) |
| "Evaluate the ease of use and tolerability of labetalol (L) and nicardipine (N) for hypertension management in patients with acute stroke." | 3.74 | A comparison of nicardipine and labetalol for acute hypertension management following stroke. ( Coplin, WM; Janisse, J; Liu-Deryke, X; Norris, G; Parker, D; Rhoney, DH, 2008) |
| "Differentiation from acute cerebral ischemia is important in order to prevent permanent vision loss due to delay in initiating prompt and vigorous treatment of exacerbating factors, such as intermittent hypertension." | 1.36 | Postoperative blindness associated with posterior reversible encephalopathy syndrome: a case report. ( Kim, TK; Kim, WS; Lee, HJ; Park, SC; Yoon, JU; Yoon, JY, 2010) |
| "We introduced intracerebral hemorrhage in 12 anesthetized dogs by autologous blood injection under arterial pressure in the deep white matter adjacent to the left caudate region." | 1.30 | Pharmacologic reduction of mean arterial pressure does not adversely affect regional cerebral blood flow and intracranial pressure in experimental intracerebral hemorrhage. ( Hanley, DF; Qureshi, AI; Traystman, RJ; Wilson, DA, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Watson, K | 1 |
| Broscious, R | 1 |
| Devabhakthuni, S | 1 |
| Noel, ZR | 1 |
| Sharma, VK | 1 |
| Tan, BYQ | 1 |
| Sim, MY | 1 |
| Kulkarni, A | 1 |
| Seow, PA | 1 |
| Hong, CS | 1 |
| Du, Z | 1 |
| Wong, LYH | 1 |
| Chen, J | 1 |
| Chee, EYH | 1 |
| Ng, BSM | 1 |
| Low, Y | 1 |
| Ngiam, NJH | 1 |
| Yeo, LLL | 1 |
| Teoh, HL | 1 |
| Paliwal, PR | 1 |
| Rathakrishnan, R | 1 |
| Sinha, AK | 1 |
| Chan, BPL | 1 |
| Butcher, K | 1 |
| Anderson, CS | 1 |
| Sadeghi, M | 1 |
| Saber, H | 1 |
| Singh, A | 1 |
| Hanni, C | 1 |
| Parker, D | 2 |
| Desai, A | 1 |
| Mohamed, W | 1 |
| McKay, C | 1 |
| Hall, AB | 1 |
| Cortes, J | 1 |
| Kim, TK | 1 |
| Yoon, JU | 1 |
| Park, SC | 1 |
| Lee, HJ | 1 |
| Kim, WS | 1 |
| Yoon, JY | 1 |
| Lindsberg, PJ | 1 |
| Soinne, L | 1 |
| Roine, RO | 1 |
| Salonen, O | 1 |
| Tatlisumak, T | 1 |
| Kallela, M | 1 |
| Häppölä, O | 1 |
| Tiainen, M | 1 |
| Haapaniemi, E | 1 |
| Kuisma, M | 1 |
| Kaste, M | 1 |
| Semplicini, A | 1 |
| Calò, L | 1 |
| Donaghy, S | 1 |
| Mocco, J | 1 |
| Rose, JC | 1 |
| Komotar, RJ | 1 |
| Mayer, SA | 1 |
| Liu-Deryke, X | 1 |
| Janisse, J | 1 |
| Coplin, WM | 1 |
| Norris, G | 1 |
| Rhoney, DH | 1 |
| Qureshi, AI | 1 |
| Wilson, DA | 1 |
| Hanley, DF | 1 |
| Traystman, RJ | 1 |
| Zazulia, AR | 1 |
| Diringer, MN | 1 |
| Videen, TO | 1 |
| Adams, RE | 1 |
| Yundt, K | 1 |
| Aiyagari, V | 1 |
| Grubb, RL | 1 |
| Powers, WJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised Clinical Trial for Evaluating the Safety and Feasibility of Intensive Lowering of Blood Pressure in Acute Ischemic Stroke Patients Treated With Intravenous Thrombolysis[NCT03443596] | Phase 2/Phase 3 | 54 participants (Actual) | Interventional | 2014-12-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for labetalol and Cerebral Ischemia
| Article | Year |
|---|---|
Focused Update on Pharmacologic Management of Hypertensive Emergencies.
Topics: Administration, Oral; Antihypertensive Agents; Blood Pressure; Brain Ischemia; Emergencies; Enalapri | 2018 |
Blood pressure management in patients with intracerebral and subarachnoid hemorrhage.
Topics: Antihypertensive Agents; Blood Flow Velocity; Blood Pressure; Blood Volume; Brain; Brain Ischemia; E | 2006 |
2 trials available for labetalol and Cerebral Ischemia
| Article | Year |
|---|---|
Rationale and design of a randomized trial of early intensive blood pressure lowering on cerebral perfusion parameters in thrombolysed acute ischemic stroke patients.
Topics: Administration, Intravenous; Adult; Antihypertensive Agents; Blood Pressure; Brain Ischemia; Cerebro | 2018 |
Community-based thrombolytic therapy of acute ischemic stroke in Helsinki.
Topics: Academic Medical Centers; Acute Disease; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Bl | 2003 |
8 other studies available for labetalol and Cerebral Ischemia
| Article | Year |
|---|---|
Nicardipine Associated Risk of Short-Term Mortality in Critically Ill Patients with Ischemic Stroke.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Brain Ischemia; Critical Illness; Databases, Factual; | 2019 |
Time to Blood Pressure Control Before Thrombolytic Therapy in Patients With Acute Ischemic Stroke: Comparison of Labetalol, Nicardipine, and Hydralazine.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Brain Ischemia; Female; Fib | 2015 |
Postoperative blindness associated with posterior reversible encephalopathy syndrome: a case report.
Topics: Adrenergic beta-Antagonists; Adult; Blindness; Brain Diseases; Brain Ischemia; Diagnosis, Differenti | 2010 |
Administering antihypertensive drugs after acute ischemic stroke: timing is everything.
Topics: Acute Disease; Antihypertensive Agents; Brain; Brain Ischemia; Cerebrovascular Circulation; Homeosta | 2005 |
Choice of antihypertensives after acute ischemic stroke.
Topics: Acute Disease; Antihypertensive Agents; Brain Ischemia; Drug Administration Schedule; Humans; Labeta | 2005 |
A comparison of nicardipine and labetalol for acute hypertension management following stroke.
Topics: Acute Disease; Aged; Antihypertensive Agents; APACHE; Blood Pressure; Brain Ischemia; Cerebral Hemor | 2008 |
Pharmacologic reduction of mean arterial pressure does not adversely affect regional cerebral blood flow and intracranial pressure in experimental intracerebral hemorrhage.
Topics: Animals; Antihypertensive Agents; Blood Flow Velocity; Blood Pressure; Brain Ischemia; Cerebral Hemo | 1999 |
Hypoperfusion without ischemia surrounding acute intracerebral hemorrhage.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Flow Velocity; Blood Pressure; Brain; | 2001 |