labetalol has been researched along with Cardiomegaly in 10 studies
Labetalol: A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.
labetalol : A diastereoisomeric mixture of approximately equal amounts of all four possible stereoisomers ((R,S)-labetolol, (S,R)-labetolol, (S,S)-labetalol and (R,R)-labetalol). It is an adrenergic antagonist used to treat high blood pressure.
2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide : A member of the class of benzamides that is benzamide substituted by a hydroxy group at position 2 and by a 1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl group at position 5.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of angiotensin II (ANG II) in the development of isoproterenol (Iso)-induced cardiac hypertrophy was examined in rats." | 7.69 | Angiotensin II maintains, but does not mediate, isoproterenol-induced cardiac hypertrophy in rats. ( Abassi, ZA; Cuda, G; Golomb, E; Keiser, HR; Panchal, VR; Stylianou, M; Trachewsky, D, 1994) |
| "We determined echocardiographic (M-mode) indices of left ventricular mass and function serially at 1-month intervals in 10 patients with uncomplicated mild or moderate essential hypertension, before and after adequate control of blood pressure with labetalol, a combined alpha- and beta-receptor blocking agent." | 7.67 | Effects of labetalol on left ventricular mass and function in hypertension--an assessment by serial echocardiography. ( Bhatia, ML; Kaul, U; Mohan, JC, 1984) |
| "Two infants with features of severe beta adrenergic blockade, pericardial effusions, and myocardial hypertrophy were born to mothers receiving long term treatment with oral labetalol for hypertension in pregnancy." | 3.70 | Adverse neonatal effects of maternal labetalol treatment. ( Crooks, BN; Deshpande, SA; Hall, C; Milligan, DW; Platt, MP, 1998) |
| "The role of angiotensin II (ANG II) in the development of isoproterenol (Iso)-induced cardiac hypertrophy was examined in rats." | 3.69 | Angiotensin II maintains, but does not mediate, isoproterenol-induced cardiac hypertrophy in rats. ( Abassi, ZA; Cuda, G; Golomb, E; Keiser, HR; Panchal, VR; Stylianou, M; Trachewsky, D, 1994) |
| "We determined echocardiographic (M-mode) indices of left ventricular mass and function serially at 1-month intervals in 10 patients with uncomplicated mild or moderate essential hypertension, before and after adequate control of blood pressure with labetalol, a combined alpha- and beta-receptor blocking agent." | 3.67 | Effects of labetalol on left ventricular mass and function in hypertension--an assessment by serial echocardiography. ( Bhatia, ML; Kaul, U; Mohan, JC, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (50.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kujal, P | 1 |
| Chábová, VČ | 1 |
| Vernerová, Z | 1 |
| Walkowska, A | 1 |
| Kompanowska-Jezierska, E | 1 |
| Sadowski, J | 1 |
| Vaňourková, Z | 1 |
| Husková, Z | 1 |
| Opočenský, M | 1 |
| Skaroupková, P | 1 |
| Schejbalová, S | 1 |
| Kramer, HJ | 1 |
| Rakušan, D | 1 |
| Malý, J | 1 |
| Netuka, I | 1 |
| Vaněčková, I | 1 |
| Kopkan, L | 1 |
| Cervenka, L | 1 |
| Kaul, U | 1 |
| Mohan, JC | 1 |
| Bhatia, ML | 1 |
| Golomb, E | 1 |
| Abassi, ZA | 1 |
| Cuda, G | 1 |
| Stylianou, M | 1 |
| Panchal, VR | 1 |
| Trachewsky, D | 1 |
| Keiser, HR | 1 |
| Crooks, BN | 1 |
| Deshpande, SA | 1 |
| Hall, C | 1 |
| Platt, MP | 1 |
| Milligan, DW | 1 |
| D'Ascia, C | 1 |
| Rengo, F | 1 |
| Manzolillo, G | 1 |
| Maione, S | 1 |
| Bonaduce, D | 1 |
| Brevetti, G | 1 |
| Condorelli, M | 1 |
| Foster, E | 1 |
| Plehn, JF | 1 |
| Bernard, SA | 1 |
| Battinelli, NJ | 1 |
| Huntington-Coats, M | 1 |
| Apstein, CS | 1 |
| Szlachcic, J | 1 |
| Hall, WD | 1 |
| Tubau, JF | 1 |
| Porter, V | 1 |
| Vollmer, C | 1 |
| Wollam, G | 1 |
| Hirsch, A | 1 |
| Massie, B | 1 |
| Messerli, FH | 1 |
| Glasser, SP | 1 |
| Koehn, DK | 1 |
| Powell, R | 1 |
| Zanozdra, NS | 1 |
| Kupchinskaia, EG | 1 |
| Svishchenko, EP | 1 |
| Chernoguz, LS | 1 |
| Malyshko, LN | 1 |
1 review available for labetalol and Cardiomegaly
| Article | Year |
|---|---|
Hemodynamic and cardiac adaptation in essential hypertension. Consequences for therapy.
Topics: Adaptation, Physiological; Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aging; Black People | 1985 |
2 trials available for labetalol and Cardiomegaly
| Article | Year |
|---|---|
Left ventricular hypertrophy reversal with labetalol and propranolol: a prospective randomized, double-blind study.
Topics: Adult; Blood Pressure; Cardiomegaly; Double-Blind Method; Echocardiography; Female; Heart Rate; Huma | 1990 |
Regression of left ventricular hypertrophy in treated hypertensive patients with dilevalol and metoprolol--a double blind randomized study.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Cardiomegaly; Double-Blind Method; Echocardiography; Elect | 1989 |
7 other studies available for labetalol and Cardiomegaly
| Article | Year |
|---|---|
Similar renoprotection after renin-angiotensin-dependent and -independent antihypertensive therapy in 5/6-nephrectomized Ren-2 transgenic rats: are there blood pressure-independent effects?
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme | 2010 |
Effects of labetalol on left ventricular mass and function in hypertension--an assessment by serial echocardiography.
Topics: Adult; Cardiomegaly; Echocardiography; Ethanolamines; Female; Heart; Humans; Hypertension; Labetalol | 1984 |
Angiotensin II maintains, but does not mediate, isoproterenol-induced cardiac hypertrophy in rats.
Topics: Actins; Angiotensin II; Animals; Base Sequence; Biphenyl Compounds; Blood Pressure; Captopril; Cardi | 1994 |
Adverse neonatal effects of maternal labetalol treatment.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adult; Cardiomegaly; Dobutamine; Dopamine; Dr | 1998 |
[Protective effect of labetalol in myocardial hypertrophy caused by experimentally-induced aortic stenosis in the rat].
Topics: Animals; Aortic Stenosis, Subvalvular; Cardiomegaly; Cardiomyopathies; Cardiomyopathy, Hypertrophic; | 1978 |
Regression of left ventricular hypertrophy in "previously untreated" hypertensive blacks after 6 months of blood pressure reduction with alpha- and beta-adrenergic blockade and thiazide therapy.
Topics: Adult; Aged; Black People; Blood Pressure; Cardiomegaly; Drug Therapy, Combination; Echocardiography | 1992 |
[Structural and functional status of the myocardium in patients with hypertension after long-term use of albetol].
Topics: Adult; Cardiomegaly; Hemodynamics; Humans; Hypertension; Labetalol; Male; Middle Aged; Myocardial Co | 1988 |