labetalol has been researched along with Cardiac Hypertrophy in 10 studies
Labetalol: A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.
labetalol : A diastereoisomeric mixture of approximately equal amounts of all four possible stereoisomers ((R,S)-labetolol, (S,R)-labetolol, (S,S)-labetalol and (R,R)-labetalol). It is an adrenergic antagonist used to treat high blood pressure.
2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide : A member of the class of benzamides that is benzamide substituted by a hydroxy group at position 2 and by a 1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl group at position 5.
Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of angiotensin II (ANG II) in the development of isoproterenol (Iso)-induced cardiac hypertrophy was examined in rats." | 7.69 | Angiotensin II maintains, but does not mediate, isoproterenol-induced cardiac hypertrophy in rats. ( Abassi, ZA; Cuda, G; Golomb, E; Keiser, HR; Panchal, VR; Stylianou, M; Trachewsky, D, 1994) |
| "We determined echocardiographic (M-mode) indices of left ventricular mass and function serially at 1-month intervals in 10 patients with uncomplicated mild or moderate essential hypertension, before and after adequate control of blood pressure with labetalol, a combined alpha- and beta-receptor blocking agent." | 7.67 | Effects of labetalol on left ventricular mass and function in hypertension--an assessment by serial echocardiography. ( Bhatia, ML; Kaul, U; Mohan, JC, 1984) |
| "Two infants with features of severe beta adrenergic blockade, pericardial effusions, and myocardial hypertrophy were born to mothers receiving long term treatment with oral labetalol for hypertension in pregnancy." | 3.70 | Adverse neonatal effects of maternal labetalol treatment. ( Crooks, BN; Deshpande, SA; Hall, C; Milligan, DW; Platt, MP, 1998) |
| "The role of angiotensin II (ANG II) in the development of isoproterenol (Iso)-induced cardiac hypertrophy was examined in rats." | 3.69 | Angiotensin II maintains, but does not mediate, isoproterenol-induced cardiac hypertrophy in rats. ( Abassi, ZA; Cuda, G; Golomb, E; Keiser, HR; Panchal, VR; Stylianou, M; Trachewsky, D, 1994) |
| "We determined echocardiographic (M-mode) indices of left ventricular mass and function serially at 1-month intervals in 10 patients with uncomplicated mild or moderate essential hypertension, before and after adequate control of blood pressure with labetalol, a combined alpha- and beta-receptor blocking agent." | 3.67 | Effects of labetalol on left ventricular mass and function in hypertension--an assessment by serial echocardiography. ( Bhatia, ML; Kaul, U; Mohan, JC, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (50.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kujal, P | 1 |
| Chábová, VČ | 1 |
| Vernerová, Z | 1 |
| Walkowska, A | 1 |
| Kompanowska-Jezierska, E | 1 |
| Sadowski, J | 1 |
| Vaňourková, Z | 1 |
| Husková, Z | 1 |
| Opočenský, M | 1 |
| Skaroupková, P | 1 |
| Schejbalová, S | 1 |
| Kramer, HJ | 1 |
| Rakušan, D | 1 |
| Malý, J | 1 |
| Netuka, I | 1 |
| Vaněčková, I | 1 |
| Kopkan, L | 1 |
| Cervenka, L | 1 |
| Kaul, U | 1 |
| Mohan, JC | 1 |
| Bhatia, ML | 1 |
| Golomb, E | 1 |
| Abassi, ZA | 1 |
| Cuda, G | 1 |
| Stylianou, M | 1 |
| Panchal, VR | 1 |
| Trachewsky, D | 1 |
| Keiser, HR | 1 |
| Crooks, BN | 1 |
| Deshpande, SA | 1 |
| Hall, C | 1 |
| Platt, MP | 1 |
| Milligan, DW | 1 |
| D'Ascia, C | 1 |
| Rengo, F | 1 |
| Manzolillo, G | 1 |
| Maione, S | 1 |
| Bonaduce, D | 1 |
| Brevetti, G | 1 |
| Condorelli, M | 1 |
| Foster, E | 1 |
| Plehn, JF | 1 |
| Bernard, SA | 1 |
| Battinelli, NJ | 1 |
| Huntington-Coats, M | 1 |
| Apstein, CS | 1 |
| Szlachcic, J | 1 |
| Hall, WD | 1 |
| Tubau, JF | 1 |
| Porter, V | 1 |
| Vollmer, C | 1 |
| Wollam, G | 1 |
| Hirsch, A | 1 |
| Massie, B | 1 |
| Messerli, FH | 1 |
| Glasser, SP | 1 |
| Koehn, DK | 1 |
| Powell, R | 1 |
| Zanozdra, NS | 1 |
| Kupchinskaia, EG | 1 |
| Svishchenko, EP | 1 |
| Chernoguz, LS | 1 |
| Malyshko, LN | 1 |
1 review available for labetalol and Cardiac Hypertrophy
| Article | Year |
|---|---|
Hemodynamic and cardiac adaptation in essential hypertension. Consequences for therapy.
Topics: Adaptation, Physiological; Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aging; Black People | 1985 |
2 trials available for labetalol and Cardiac Hypertrophy
| Article | Year |
|---|---|
Left ventricular hypertrophy reversal with labetalol and propranolol: a prospective randomized, double-blind study.
Topics: Adult; Blood Pressure; Cardiomegaly; Double-Blind Method; Echocardiography; Female; Heart Rate; Huma | 1990 |
Regression of left ventricular hypertrophy in treated hypertensive patients with dilevalol and metoprolol--a double blind randomized study.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Cardiomegaly; Double-Blind Method; Echocardiography; Elect | 1989 |
7 other studies available for labetalol and Cardiac Hypertrophy
| Article | Year |
|---|---|
Similar renoprotection after renin-angiotensin-dependent and -independent antihypertensive therapy in 5/6-nephrectomized Ren-2 transgenic rats: are there blood pressure-independent effects?
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme | 2010 |
Effects of labetalol on left ventricular mass and function in hypertension--an assessment by serial echocardiography.
Topics: Adult; Cardiomegaly; Echocardiography; Ethanolamines; Female; Heart; Humans; Hypertension; Labetalol | 1984 |
Angiotensin II maintains, but does not mediate, isoproterenol-induced cardiac hypertrophy in rats.
Topics: Actins; Angiotensin II; Animals; Base Sequence; Biphenyl Compounds; Blood Pressure; Captopril; Cardi | 1994 |
Adverse neonatal effects of maternal labetalol treatment.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adult; Cardiomegaly; Dobutamine; Dopamine; Dr | 1998 |
[Protective effect of labetalol in myocardial hypertrophy caused by experimentally-induced aortic stenosis in the rat].
Topics: Animals; Aortic Stenosis, Subvalvular; Cardiomegaly; Cardiomyopathies; Cardiomyopathy, Hypertrophic; | 1978 |
Regression of left ventricular hypertrophy in "previously untreated" hypertensive blacks after 6 months of blood pressure reduction with alpha- and beta-adrenergic blockade and thiazide therapy.
Topics: Adult; Aged; Black People; Blood Pressure; Cardiomegaly; Drug Therapy, Combination; Echocardiography | 1992 |
[Structural and functional status of the myocardium in patients with hypertension after long-term use of albetol].
Topics: Adult; Cardiomegaly; Hemodynamics; Humans; Hypertension; Labetalol; Male; Middle Aged; Myocardial Co | 1988 |