labetalol has been researched along with Brain Hemorrhage, Cerebral in 16 studies
Labetalol: A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.
labetalol : A diastereoisomeric mixture of approximately equal amounts of all four possible stereoisomers ((R,S)-labetolol, (S,R)-labetolol, (S,S)-labetalol and (R,R)-labetalol). It is an adrenergic antagonist used to treat high blood pressure.
2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide : A member of the class of benzamides that is benzamide substituted by a hydroxy group at position 2 and by a 1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conducted a single-center, retrospective chart review of individuals diagnosed with spontaneous intracerebral hemorrhage (ICH) receiving labetalol, hydralazine, and/or nicardipine within 24 h of hospital admission to assess the primary endpoint of BPV, defined as the standard deviation of systolic BP, with labetalol and/or hydralazine compared to nicardipine ± labetalol and/or hydralazine." | 7.91 | Nicardipine Reduces Blood Pressure Variability After Spontaneous Intracerebral Hemorrhage. ( Dierkhising, RA; Kuper, PJ; Mara, KC; Poyant, JO; Rabinstein, AA; Ritchie, BM; Wijdicks, EFM, 2019) |
| "Nicardipine and labetalol are two commonly used antihypertensives for treating elevated blood pressures in the setting of intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH)." | 7.79 | Effectiveness and safety of nicardipine and labetalol infusion for blood pressure management in patients with intracerebral and subarachnoid hemorrhage. ( Agarwal, S; Badjatia, N; Carpenter, AM; Claassen, J; Lantigua, H; Lee, K; Lesch, C; Li, M; Mayer, SA; Ortega-Gutierrez, S; Reccius, A; Schmidt, JM; Thomas, J, 2013) |
| "Evaluate the ease of use and tolerability of labetalol (L) and nicardipine (N) for hypertension management in patients with acute stroke." | 7.74 | A comparison of nicardipine and labetalol for acute hypertension management following stroke. ( Coplin, WM; Janisse, J; Liu-Deryke, X; Norris, G; Parker, D; Rhoney, DH, 2008) |
| "We conducted a single-center, retrospective chart review of individuals diagnosed with spontaneous intracerebral hemorrhage (ICH) receiving labetalol, hydralazine, and/or nicardipine within 24 h of hospital admission to assess the primary endpoint of BPV, defined as the standard deviation of systolic BP, with labetalol and/or hydralazine compared to nicardipine ± labetalol and/or hydralazine." | 3.91 | Nicardipine Reduces Blood Pressure Variability After Spontaneous Intracerebral Hemorrhage. ( Dierkhising, RA; Kuper, PJ; Mara, KC; Poyant, JO; Rabinstein, AA; Ritchie, BM; Wijdicks, EFM, 2019) |
| "Nicardipine and labetalol are two commonly used antihypertensives for treating elevated blood pressures in the setting of intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH)." | 3.79 | Effectiveness and safety of nicardipine and labetalol infusion for blood pressure management in patients with intracerebral and subarachnoid hemorrhage. ( Agarwal, S; Badjatia, N; Carpenter, AM; Claassen, J; Lantigua, H; Lee, K; Lesch, C; Li, M; Mayer, SA; Ortega-Gutierrez, S; Reccius, A; Schmidt, JM; Thomas, J, 2013) |
| "Evaluate the ease of use and tolerability of labetalol (L) and nicardipine (N) for hypertension management in patients with acute stroke." | 3.74 | A comparison of nicardipine and labetalol for acute hypertension management following stroke. ( Coplin, WM; Janisse, J; Liu-Deryke, X; Norris, G; Parker, D; Rhoney, DH, 2008) |
| " Initial dosing with nicardipine lowered acute diastolic BP than labetalol (least square mean difference (labetalol-nicardipine)=5." | 3.11 | Initial antihypertensive agent effects on acute blood pressure after intracerebral haemorrhage. ( Behymer, TP; Bettin, M; Christianson, T; Coleman, ER; Divani, A; Flaherty, ML; Gilkerson, LA; James, ML; King, NKK; Krishnamoorthy, V; Langefeld, CD; McCauley, JL; Ng, Y; Qi, W; Shah, S; Testai, FD; Walsh, KB; Woo, D, 2022) |
| "Blood pressure (BP) reduction after intracerebral hemorrhage (ICH) is controversial, because of concerns that this may cause critical reductions in perihematoma perfusion and thereby precipitate tissue damage." | 2.79 | Blood pressure reduction does not reduce perihematoma oxygenation: a CT perfusion study. ( Buck, BH; Butcher, KS; Choi, V; Coutts, SB; Demchuk, AM; Dowlatshahi, D; Emery, DJ; Gould, BE; Hansen, MB; Hill, MD; Kate, MP; McCourt, R; Mouridsen, K; Østergaard, L, 2014) |
| "Hypertension that complicates preeclampsia in pregnancy is a disorder that requires special consideration in both prevention and pharmacologic treatment." | 2.43 | Pathophysiology and medical management of systemic hypertension in preeclampsia. ( Frishman, WH; Schlocker, SJ; Tejani, N; Veresh, M, 2006) |
| " The long-term use of short-acting nifedipine for 30 days was associated with a modest increase in the risk for ischemic stroke (OR 1." | 1.51 | Oral short-acting antihypertensive medications and the occurrence of stroke: a nationwide case-crossover study. ( Chen, PC; Hsu, CY; Huang, LY; Lee, JD; Lee, M; Ovbiagele, B; Saver, JL; Wu, YL, 2019) |
| "We introduced intracerebral hemorrhage in 12 anesthetized dogs by autologous blood injection under arterial pressure in the deep white matter adjacent to the left caudate region." | 1.30 | Pharmacologic reduction of mean arterial pressure does not adversely affect regional cerebral blood flow and intracranial pressure in experimental intracerebral hemorrhage. ( Hanley, DF; Qureshi, AI; Traystman, RJ; Wilson, DA, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Ng, Y | 1 |
| Qi, W | 1 |
| King, NKK | 1 |
| Christianson, T | 1 |
| Krishnamoorthy, V | 1 |
| Shah, S | 1 |
| Divani, A | 1 |
| Bettin, M | 1 |
| Coleman, ER | 1 |
| Flaherty, ML | 1 |
| Walsh, KB | 1 |
| Testai, FD | 1 |
| McCauley, JL | 1 |
| Gilkerson, LA | 1 |
| Langefeld, CD | 1 |
| Behymer, TP | 1 |
| Woo, D | 1 |
| James, ML | 1 |
| Starr, JB | 1 |
| Tirschwell, DL | 1 |
| Becker, KJ | 1 |
| Poyant, JO | 1 |
| Kuper, PJ | 1 |
| Mara, KC | 1 |
| Dierkhising, RA | 1 |
| Rabinstein, AA | 1 |
| Wijdicks, EFM | 1 |
| Ritchie, BM | 1 |
| Hsu, CY | 1 |
| Huang, LY | 1 |
| Saver, JL | 1 |
| Wu, YL | 1 |
| Lee, JD | 1 |
| Chen, PC | 1 |
| Lee, M | 1 |
| Ovbiagele, B | 1 |
| Kate, MP | 1 |
| Hansen, MB | 1 |
| Mouridsen, K | 1 |
| Østergaard, L | 1 |
| Choi, V | 1 |
| Gould, BE | 1 |
| McCourt, R | 1 |
| Hill, MD | 1 |
| Demchuk, AM | 1 |
| Coutts, SB | 1 |
| Dowlatshahi, D | 1 |
| Emery, DJ | 1 |
| Buck, BH | 1 |
| Butcher, KS | 2 |
| Sebastian, J | 1 |
| Emery, D | 1 |
| Kotylak, T | 1 |
| Ortega-Gutierrez, S | 1 |
| Thomas, J | 1 |
| Reccius, A | 1 |
| Agarwal, S | 1 |
| Lantigua, H | 1 |
| Li, M | 1 |
| Carpenter, AM | 1 |
| Mayer, SA | 1 |
| Schmidt, JM | 1 |
| Lee, K | 1 |
| Claassen, J | 1 |
| Badjatia, N | 1 |
| Lesch, C | 1 |
| Lindsberg, PJ | 1 |
| Soinne, L | 1 |
| Roine, RO | 1 |
| Salonen, O | 1 |
| Tatlisumak, T | 1 |
| Kallela, M | 1 |
| Häppölä, O | 1 |
| Tiainen, M | 1 |
| Haapaniemi, E | 1 |
| Kuisma, M | 1 |
| Kaste, M | 1 |
| Frishman, WH | 1 |
| Veresh, M | 1 |
| Schlocker, SJ | 1 |
| Tejani, N | 1 |
| Liu-Deryke, X | 1 |
| Janisse, J | 1 |
| Coplin, WM | 1 |
| Parker, D | 1 |
| Norris, G | 1 |
| Rhoney, DH | 1 |
| Patel, RV | 1 |
| Kertland, HR | 1 |
| Jahns, BE | 1 |
| Zarowitz, BJ | 1 |
| Mlynarek, ME | 1 |
| Fagan, SC | 2 |
| Bowes, MP | 1 |
| Lyden, PD | 1 |
| Zivin, JA | 1 |
| Kochanek, PM | 1 |
| Snyder, JV | 1 |
| Bircher, NG | 1 |
| Qureshi, AI | 1 |
| Wilson, DA | 1 |
| Hanley, DF | 1 |
| Traystman, RJ | 1 |
| Zazulia, AR | 2 |
| Diringer, MN | 2 |
| Videen, TO | 2 |
| Adams, RE | 2 |
| Yundt, K | 1 |
| Aiyagari, V | 2 |
| Grubb, RL | 2 |
| Powers, WJ | 2 |
| Yundt, KD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH)[NCT01202864] | 6,000 participants (Actual) | Observational | 2010-08-01 | Completed | |||
| Clinical Study of the Safety and Efficacy of Analgesia-first Minimal Sedation as an Early Antihypertensive Treatment for Spontaneous Intracerebral Hemorrhage[NCT03207100] | 338 participants (Actual) | Interventional | 2017-12-06 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for labetalol and Brain Hemorrhage, Cerebral
| Article | Year |
|---|---|
Pathophysiology and medical management of systemic hypertension in preeclampsia.
Topics: Adrenergic beta-Antagonists; Aspirin; Calcium; Calcium Channel Blockers; Cerebral Hemorrhage; Female | 2006 |
How low can you go? Blood pressure control after intracranial hemorrhage.
Topics: Animals; Antihypertensive Agents; Basal Ganglia; Blood Pressure; Cerebral Hemorrhage; Cerebrovascula | 1999 |
5 trials available for labetalol and Brain Hemorrhage, Cerebral
| Article | Year |
|---|---|
Initial antihypertensive agent effects on acute blood pressure after intracerebral haemorrhage.
Topics: Antihypertensive Agents; Blood Pressure; Cerebral Hemorrhage; Humans; Hydralazine; Hypertension; Lab | 2022 |
Blood pressure reduction does not reduce perihematoma oxygenation: a CT perfusion study.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Cerebral Hemorrhage; Female; Hematoma; Humans; Hydral | 2014 |
Community-based thrombolytic therapy of acute ischemic stroke in Helsinki.
Topics: Academic Medical Centers; Acute Disease; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Bl | 2003 |
Labetalol: response and safety in critically ill hemorrhagic stroke patients.
Topics: Adult; Aged; Blood Pressure; Cerebral Hemorrhage; Cerebrovascular Disorders; Critical Illness; Femal | 1993 |
Autoregulation of cerebral blood flow surrounding acute (6 to 22 hours) intracerebral hemorrhage.
Topics: Acute Disease; Adult; Aged; Antihypertensive Agents; Blood Pressure; Cerebral Hemorrhage; Cerebrovas | 2001 |
9 other studies available for labetalol and Brain Hemorrhage, Cerebral
| Article | Year |
|---|---|
Labetalol Use Is Associated With Increased In-Hospital Infection Compared With Nicardipine Use in Intracerebral Hemorrhage.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Cerebral Hemorrhage; Cross Infect | 2017 |
Nicardipine Reduces Blood Pressure Variability After Spontaneous Intracerebral Hemorrhage.
Topics: Administration, Intravenous; Adult; Aged; Antihypertensive Agents; Blood Pressure; Cerebral Hemorrha | 2019 |
Oral short-acting antihypertensive medications and the occurrence of stroke: a nationwide case-crossover study.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Captopril; Cerebral Hemorrhage; Female; Humans; La | 2019 |
Cerebral blood flow measurement following extreme blood pressure reduction in an acute intracerebral hemorrhage patient.
Topics: Acute Disease; Antihypertensive Agents; Blood Pressure; Cerebral Hemorrhage; Cerebrovascular Circula | 2011 |
Effectiveness and safety of nicardipine and labetalol infusion for blood pressure management in patients with intracerebral and subarachnoid hemorrhage.
Topics: Adult; Aged; Antihypertensive Agents; Cerebral Hemorrhage; Cohort Studies; Drug Therapy, Combination | 2013 |
A comparison of nicardipine and labetalol for acute hypertension management following stroke.
Topics: Acute Disease; Aged; Antihypertensive Agents; APACHE; Blood Pressure; Brain Ischemia; Cerebral Hemor | 2008 |
Acute hypertension promotes hemorrhagic transformation in a rabbit embolic stroke model: effect of labetalol.
Topics: Acute Disease; Angiotensin II; Animals; Antihypertensive Agents; Cerebral Hemorrhage; Cerebral Infar | 1998 |
Pharmacologic reduction of mean arterial pressure does not adversely affect regional cerebral blood flow and intracranial pressure in experimental intracerebral hemorrhage.
Topics: Animals; Antihypertensive Agents; Blood Flow Velocity; Blood Pressure; Brain Ischemia; Cerebral Hemo | 1999 |
Hypoperfusion without ischemia surrounding acute intracerebral hemorrhage.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Flow Velocity; Blood Pressure; Brain; | 2001 |