labetalol has been researched along with Asthma in 15 studies
Labetalol: A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.
labetalol : A diastereoisomeric mixture of approximately equal amounts of all four possible stereoisomers ((R,S)-labetolol, (S,R)-labetolol, (S,S)-labetalol and (R,R)-labetalol). It is an adrenergic antagonist used to treat high blood pressure.
2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide : A member of the class of benzamides that is benzamide substituted by a hydroxy group at position 2 and by a 1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl group at position 5.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this double-blind, three-way, crossover study, the effects of relatively high single doses of dilevalol (400 mg), metoprolol (200 mg), a placebo on pulmonary function and their interaction with isoproterenol (160 and 480 micrograms) were evaluated in 16 patients with reversible bronchial asthma [isoproterenol-induced increase in forced expiratory volume in 1 s (FEV1) of greater than or equal to 15%]." | 9.06 | The effects of dilevalol, metoprolol, and placebo on ventilatory function in asthmatics. ( Blasucci, DJ; Chodosh, S; Tuck, J, 1988) |
| "The effects of labetalol, metoprolol, and placebo on pulmonary function and their interaction with isoproterenol were evaluated in 18 patients with reversible bronchial asthma [isoproterenol-induced increase in forced expiratory volume in 1 second (FEV1) of greater than or equal to 15%]." | 9.06 | Effect of single doses of labetalol, metoprolol, and placebo on ventilatory function in patients with bronchial asthma: interaction with isoproterenol. ( Falliers, CJ; Medakovic, M; Vincent, ME, 1986) |
| "The acute effect of non-selective beta-blockade alone (propranolol) or in combination with alpha-blockade (labetalol) and beta 1-selective blockade (practolol) on the airways was studied in 14 asthmatic patients." | 9.05 | Influence of labetalol, propranolol and practolol in patients with asthma. ( Larsson, K, 1982) |
| "1 The effects of atenolol (100 mg), a cardioselective beta-adrenoceptor blocking agent, and labetalol (300 mg), a combined alpha- and non-selective beta-adrenoceptor blocking agent given in single doses were examined in a double-blind placebo controlled study in 11 asthmatic patients with hypertension." | 9.05 | Comparison of the effects of single doses of atenolol and labetalol on airways obstruction in patients with hypertension and asthma. ( Beevers, DG; Jackson, SH, 1983) |
| "Previous studies have shown that labetalol, a new alpha- and beta-adrenergic antagonist, is relatively safe for the treatment of hypertension in patients with chronic obstructive pulmonary disease (COPD)." | 9.05 | Comparison of the effects of labetalol and hydrochlorothiazide on the ventilatory function of hypertensive patients with asthma and propranolol sensitivity. ( Burford, JG; Chetty, K; Conrad, SA; George, RB; Hudson, LD; Light, RW; Manocha, K, 1985) |
| "The cardiac and bronchial effects of AH 5158 and propranolol were compared in a double-blind, placebocontrolled intravenous study on 10 asthmatics." | 9.04 | Comparison of intravenous AH 5158 (ibidomide) and propranolol in asthma. ( Gaddie, J; Palmer, KN; Skinner, C, 1975) |
| ", following the initial dose of active treatment) and on each visit when the dosage was increased." | 6.66 | The effects of treatments with labetalol and hydrochlorothiazide on ventilatory function of asthmatic hypertensive patients with demonstrated bronchosensitivity to propranolol. ( Blasucci, DJ; Falliers, CJ; Maloy, JW; Medakovic, M; Vrchota, J, 1985) |
| " Experiments carried out in vitro showed that labetalol relaxed the tonus of isolated tracheal preparation, shifting the histamine dose-response curve to the right and downward." | 5.27 | [A study on the mechanism of the antiasthmatic effect of labetalol on experimental histamine-induced asthma]. ( Kameda, H; Monma, Y; Tanabe, T, 1986) |
| " In this double-blind, three-way, crossover study, the effects of relatively high single doses of dilevalol (400 mg), metoprolol (200 mg), a placebo on pulmonary function and their interaction with isoproterenol (160 and 480 micrograms) were evaluated in 16 patients with reversible bronchial asthma [isoproterenol-induced increase in forced expiratory volume in 1 s (FEV1) of greater than or equal to 15%]." | 5.06 | The effects of dilevalol, metoprolol, and placebo on ventilatory function in asthmatics. ( Blasucci, DJ; Chodosh, S; Tuck, J, 1988) |
| "The effects on baseline ventilation as well as beta 2-receptor stimulant-induced bronchodilation and tremor of atenolol and dilevalol, a beta-blocking agent with non-selective beta-antagonistic properties and intrinsic activity on the beta 2-receptor were evaluated in 8 patients with stable asthma." | 5.06 | Effects of dilevalol, a beta-adrenoceptor antagonist with intrinsic sympathetic activity in asthmatic patients. ( Hedner, J; Lemne, C; Svedmyr, N; Ullman, A, 1989) |
| "The effects of labetalol, metoprolol, and placebo on pulmonary function and their interaction with isoproterenol were evaluated in 18 patients with reversible bronchial asthma [isoproterenol-induced increase in forced expiratory volume in 1 second (FEV1) of greater than or equal to 15%]." | 5.06 | Effect of single doses of labetalol, metoprolol, and placebo on ventilatory function in patients with bronchial asthma: interaction with isoproterenol. ( Falliers, CJ; Medakovic, M; Vincent, ME, 1986) |
| "The acute effect of non-selective beta-blockade alone (propranolol) or in combination with alpha-blockade (labetalol) and beta 1-selective blockade (practolol) on the airways was studied in 14 asthmatic patients." | 5.05 | Influence of labetalol, propranolol and practolol in patients with asthma. ( Larsson, K, 1982) |
| "1 The effects of atenolol (100 mg), a cardioselective beta-adrenoceptor blocking agent, and labetalol (300 mg), a combined alpha- and non-selective beta-adrenoceptor blocking agent given in single doses were examined in a double-blind placebo controlled study in 11 asthmatic patients with hypertension." | 5.05 | Comparison of the effects of single doses of atenolol and labetalol on airways obstruction in patients with hypertension and asthma. ( Beevers, DG; Jackson, SH, 1983) |
| "Previous studies have shown that labetalol, a new alpha- and beta-adrenergic antagonist, is relatively safe for the treatment of hypertension in patients with chronic obstructive pulmonary disease (COPD)." | 5.05 | Comparison of the effects of labetalol and hydrochlorothiazide on the ventilatory function of hypertensive patients with asthma and propranolol sensitivity. ( Burford, JG; Chetty, K; Conrad, SA; George, RB; Hudson, LD; Light, RW; Manocha, K, 1985) |
| "The cardiac and bronchial effects of AH 5158 and propranolol were compared in a double-blind, placebocontrolled intravenous study on 10 asthmatics." | 5.04 | Comparison of intravenous AH 5158 (ibidomide) and propranolol in asthma. ( Gaddie, J; Palmer, KN; Skinner, C, 1975) |
| " It has also been used intravenously in phaeochromocytoma, tetanus, clonidine withdrawal, and as an adjunct to halothane to produce hypotensive anaesthesia." | 4.76 | Combined alpha- and beta-receptor inhibition in the treatment of hypertension. ( Prichard, BN, 1984) |
| " Carboprost was used less frequently in patients with asthma compared with patients with no asthma (11." | 3.88 | Use of Antihypertensive Medications and Uterotonics During Delivery Hospitalizations in Women With Asthma. ( Ananth, CV; Booker, WA; Cleary, KL; DʼAlton, ME; Friedman, AM; Huang, Y; Siddiq, Z; Wright, JD, 2018) |
| ", following the initial dose of active treatment) and on each visit when the dosage was increased." | 2.66 | The effects of treatments with labetalol and hydrochlorothiazide on ventilatory function of asthmatic hypertensive patients with demonstrated bronchosensitivity to propranolol. ( Blasucci, DJ; Falliers, CJ; Maloy, JW; Medakovic, M; Vrchota, J, 1985) |
| " Dosage ranged from 100 to 2400 mg per day (mean 654 mg per day) and treatment was continued for between 6 and 18 months (mean 7." | 1.27 | Side-effects with long-term labetalol: an open study of 251 patients in a single centre. ( Tcherdakoff, P, 1983) |
| " Experiments carried out in vitro showed that labetalol relaxed the tonus of isolated tracheal preparation, shifting the histamine dose-response curve to the right and downward." | 1.27 | [A study on the mechanism of the antiasthmatic effect of labetalol on experimental histamine-induced asthma]. ( Kameda, H; Monma, Y; Tanabe, T, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (80.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Booker, WA | 1 |
| Siddiq, Z | 1 |
| Huang, Y | 1 |
| Ananth, CV | 1 |
| Wright, JD | 1 |
| Cleary, KL | 1 |
| DʼAlton, ME | 1 |
| Friedman, AM | 1 |
| Tohda, Y | 1 |
| Larsson, K | 1 |
| Prichard, BN | 1 |
| Tcherdakoff, P | 1 |
| Jackson, SH | 1 |
| Beevers, DG | 1 |
| Skinner, C | 1 |
| Gaddie, J | 1 |
| Palmer, KN | 1 |
| Larsen, LS | 1 |
| Larsen, A | 1 |
| Chodosh, S | 1 |
| Tuck, J | 1 |
| Blasucci, DJ | 2 |
| Hedner, J | 1 |
| Ullman, A | 1 |
| Lemne, C | 1 |
| Svedmyr, N | 1 |
| Kameda, H | 1 |
| Monma, Y | 1 |
| Tanabe, T | 1 |
| Falliers, CJ | 2 |
| Vincent, ME | 1 |
| Medakovic, M | 2 |
| Vrchota, J | 1 |
| Maloy, JW | 1 |
| George, RB | 2 |
| Light, RW | 2 |
| Hudson, L | 1 |
| Conrad, SA | 2 |
| Manocha, KL | 1 |
| Burford, JG | 2 |
| Hudson, LD | 1 |
| Chetty, K | 1 |
| Manocha, K | 1 |
2 reviews available for labetalol and Asthma
| Article | Year |
|---|---|
[My research on asthma today and in the future].
Topics: Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; D | 2013 |
Combined alpha- and beta-receptor inhibition in the treatment of hypertension.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthesia; Antihyp | 1984 |
8 trials available for labetalol and Asthma
| Article | Year |
|---|---|
Influence of labetalol, propranolol and practolol in patients with asthma.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Asthma; Bronchi; | 1982 |
Comparison of the effects of single doses of atenolol and labetalol on airways obstruction in patients with hypertension and asthma.
Topics: Adult; Asthma; Atenolol; Blood Pressure; Ethanolamines; Female; Forced Expiratory Volume; Humans; Hy | 1983 |
Comparison of intravenous AH 5158 (ibidomide) and propranolol in asthma.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Asthma; Bronchi; Clinical Trials as Topic; Constrict | 1975 |
The effects of dilevalol, metoprolol, and placebo on ventilatory function in asthmatics.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Asthma; Female; Forced Expiratory Volume; Hemo | 1988 |
Effects of dilevalol, a beta-adrenoceptor antagonist with intrinsic sympathetic activity in asthmatic patients.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Asthma; Atenolol; Double-Blind Method; Female; Forced Expi | 1989 |
Effect of single doses of labetalol, metoprolol, and placebo on ventilatory function in patients with bronchial asthma: interaction with isoproterenol.
Topics: Adult; Asthma; Blood Pressure; Double-Blind Method; Drug Interactions; Female; Heart Rate; Humans; L | 1986 |
The effects of treatments with labetalol and hydrochlorothiazide on ventilatory function of asthmatic hypertensive patients with demonstrated bronchosensitivity to propranolol.
Topics: Adolescent; Adult; Aged; Asthma; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Hydr | 1985 |
Comparison of the effects of labetalol and hydrochlorothiazide on the ventilatory function of hypertensive patients with asthma and propranolol sensitivity.
Topics: Adolescent; Adult; Aged; Asthma; Clinical Trials as Topic; Drug Evaluation; Female; Forced Expirator | 1985 |
5 other studies available for labetalol and Asthma
| Article | Year |
|---|---|
Use of Antihypertensive Medications and Uterotonics During Delivery Hospitalizations in Women With Asthma.
Topics: Adult; Antihypertensive Agents; Asthma; Carboprost; Contraindications, Drug; Databases, Factual; Del | 2018 |
Side-effects with long-term labetalol: an open study of 251 patients in a single centre.
Topics: Adult; Aged; Asthma; Ethanolamines; Female; Humans; Hypertension; Hypotension, Orthostatic; Labetalo | 1983 |
Labetalol in the treatment of epinephrine overdose.
Topics: Adult; Ambulatory Care Facilities; Asthma; Epinephrine; Humans; Injections, Intravenous; Injections, | 1990 |
[A study on the mechanism of the antiasthmatic effect of labetalol on experimental histamine-induced asthma].
Topics: Animals; Asthma; Bronchodilator Agents; Female; Guinea Pigs; Histamine H1 Antagonists; In Vitro Tech | 1986 |
The use of labetalol for the treatment of hypertension in patients with reversible airway obstruction.
Topics: Airway Resistance; Asthma; Bronchitis; Forced Expiratory Flow Rates; Forced Expiratory Volume; Human | 1985 |