Page last updated: 2024-10-30

labetalol and Apoplexy

labetalol has been researched along with Apoplexy in 22 studies

Labetalol: A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.
labetalol : A diastereoisomeric mixture of approximately equal amounts of all four possible stereoisomers ((R,S)-labetolol, (S,R)-labetolol, (S,S)-labetalol and (R,R)-labetalol). It is an adrenergic antagonist used to treat high blood pressure.
2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide : A member of the class of benzamides that is benzamide substituted by a hydroxy group at position 2 and by a 1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl group at position 5.

Research Excerpts

ExcerptRelevanceReference
"This is a prospective, pseudo-randomized study comparing labetalol and nicardipine for blood pressure (BP) management in acute stroke patients."9.17A prospective evaluation of labetalol versus nicardipine for blood pressure management in patients with acute stroke. ( Coplin, W; Levy, PD; Liu-DeRyke, X; Parker, D; Rhoney, DH, 2013)
" Critical care nurses who appreciate the considerations for treatment of hypertension and who can correctly and efficiently administer intravenous labetalol may save precious time and enhance outcomes for patients with stroke who have hypertension."8.82Managing hypertension in patients with stroke. Are you prepared for labetalol infusion? ( Harrington, C, 2003)
"To assess the safety and efficacy of continuous infusion (CIV)-labetalol compared to -nicardipine in controlling blood pressure (BP) in the acute stroke setting."8.02Blood Pressure Control in Acute Stroke: Labetalol or Nicardipine? ( El-Ghoroury, H; Hecht, JP; Sudekum, DM, 2021)
" Nicardipine and labetalol are commonly administered for the treatment of acute hypertension following stroke."7.91Nicardipine Associated Risk of Short-Term Mortality in Critically Ill Patients with Ischemic Stroke. ( Desai, A; Hanni, C; Mohamed, W; Parker, D; Saber, H; Sadeghi, M; Singh, A, 2019)
"Labetalol and nicardipine are antihypertensives commonly used in the management of elevated blood pressure (BP) following an acute stroke, but there is limited evidence to suggest which agent as a continuous infusion should be used preferentially in this setting."7.88Continuous-Infusion Labetalol vs Nicardipine for Hypertension Management in Stroke Patients. ( Hecht, JP; Richards, PG, 2018)
"This study aimed to compare the effects of labetalol, nicardipine, or hydralazine on time to target blood pressure before alteplase administration in patients with acute ischemic stroke."7.81Time to Blood Pressure Control Before Thrombolytic Therapy in Patients With Acute Ischemic Stroke: Comparison of Labetalol, Nicardipine, and Hydralazine. ( Cortes, J; Hall, AB; McKay, C, 2015)
"Routine use of preoperative metoprolol, but not atenolol, is associated with stroke after noncardiac surgery, even after adjusting for comorbidities."7.79Perioperative metoprolol and risk of stroke after noncardiac surgery. ( Freundlich, RE; Kheterpal, S; Mashour, GA; Matlen, L; Merte, J; Nallamothu, BK; Shanks, A; Sharifpour, M; Tremper, KK; Vlisides, PE; Weightman, A, 2013)
"American Heart Association/American Stroke Association guidelines for management of aneurysmal subarachnoid hemorrhage (aSAH) recommend blood pressure (BP) control, utilizing labetalol or nicardipine, but do not differentiate efficacy between the two agents."7.78Retrospective evaluation of nicardipine versus labetalol for blood pressure control in aneurysmal subarachnoid hemorrhage. ( Barletta, JF; DeShane, RS; Figueroa, BE; McAllen, KJ; Woloszyn, AV, 2012)
"Evaluate the ease of use and tolerability of labetalol (L) and nicardipine (N) for hypertension management in patients with acute stroke."7.74A comparison of nicardipine and labetalol for acute hypertension management following stroke. ( Coplin, WM; Janisse, J; Liu-Deryke, X; Norris, G; Parker, D; Rhoney, DH, 2008)
"This is a prospective, pseudo-randomized study comparing labetalol and nicardipine for blood pressure (BP) management in acute stroke patients."5.17A prospective evaluation of labetalol versus nicardipine for blood pressure management in patients with acute stroke. ( Coplin, W; Levy, PD; Liu-DeRyke, X; Parker, D; Rhoney, DH, 2013)
"Labetalol and lisinopril are effective antihypertensive drugs in acute stroke that do not increase serious adverse events."5.14Controlling hypertension and hypotension immediately post-stroke (CHHIPS): a randomised, placebo-controlled, double-blind pilot trial. ( Chernova, J; Ford, GA; Jagger, C; James, M; Mistri, A; Potter, JF; Robinson, TG, 2009)
" Oral nifedipine is now considered an alternative first-line therapy, along with intravenous hydralazine and labetalol for women presenting with pre-eclampsia."4.98Focused Update on Pharmacologic Management of Hypertensive Emergencies. ( Broscious, R; Devabhakthuni, S; Noel, ZR; Watson, K, 2018)
" Critical care nurses who appreciate the considerations for treatment of hypertension and who can correctly and efficiently administer intravenous labetalol may save precious time and enhance outcomes for patients with stroke who have hypertension."4.82Managing hypertension in patients with stroke. Are you prepared for labetalol infusion? ( Harrington, C, 2003)
"To assess the safety and efficacy of continuous infusion (CIV)-labetalol compared to -nicardipine in controlling blood pressure (BP) in the acute stroke setting."4.02Blood Pressure Control in Acute Stroke: Labetalol or Nicardipine? ( El-Ghoroury, H; Hecht, JP; Sudekum, DM, 2021)
" Nicardipine and labetalol are commonly administered for the treatment of acute hypertension following stroke."3.91Nicardipine Associated Risk of Short-Term Mortality in Critically Ill Patients with Ischemic Stroke. ( Desai, A; Hanni, C; Mohamed, W; Parker, D; Saber, H; Sadeghi, M; Singh, A, 2019)
"Labetalol and nicardipine are antihypertensives commonly used in the management of elevated blood pressure (BP) following an acute stroke, but there is limited evidence to suggest which agent as a continuous infusion should be used preferentially in this setting."3.88Continuous-Infusion Labetalol vs Nicardipine for Hypertension Management in Stroke Patients. ( Hecht, JP; Richards, PG, 2018)
"This study aimed to compare the effects of labetalol, nicardipine, or hydralazine on time to target blood pressure before alteplase administration in patients with acute ischemic stroke."3.81Time to Blood Pressure Control Before Thrombolytic Therapy in Patients With Acute Ischemic Stroke: Comparison of Labetalol, Nicardipine, and Hydralazine. ( Cortes, J; Hall, AB; McKay, C, 2015)
"Routine use of preoperative metoprolol, but not atenolol, is associated with stroke after noncardiac surgery, even after adjusting for comorbidities."3.79Perioperative metoprolol and risk of stroke after noncardiac surgery. ( Freundlich, RE; Kheterpal, S; Mashour, GA; Matlen, L; Merte, J; Nallamothu, BK; Shanks, A; Sharifpour, M; Tremper, KK; Vlisides, PE; Weightman, A, 2013)
"American Heart Association/American Stroke Association guidelines for management of aneurysmal subarachnoid hemorrhage (aSAH) recommend blood pressure (BP) control, utilizing labetalol or nicardipine, but do not differentiate efficacy between the two agents."3.78Retrospective evaluation of nicardipine versus labetalol for blood pressure control in aneurysmal subarachnoid hemorrhage. ( Barletta, JF; DeShane, RS; Figueroa, BE; McAllen, KJ; Woloszyn, AV, 2012)
"Evaluate the ease of use and tolerability of labetalol (L) and nicardipine (N) for hypertension management in patients with acute stroke."3.74A comparison of nicardipine and labetalol for acute hypertension management following stroke. ( Coplin, WM; Janisse, J; Liu-Deryke, X; Norris, G; Parker, D; Rhoney, DH, 2008)
"In the case of hypertensive encephalopathy, the lowering of blood pressure is therapeutic as well as diagnostic."2.43[Antihypertensive management in acute cerebral stroke]. ( Ziliene, V, 2005)
"Hypertension that complicates preeclampsia in pregnancy is a disorder that requires special consideration in both prevention and pharmacologic treatment."2.43Pathophysiology and medical management of systemic hypertension in preeclampsia. ( Frishman, WH; Schlocker, SJ; Tejani, N; Veresh, M, 2006)
" The long-term use of short-acting nifedipine for 30 days was associated with a modest increase in the risk for ischemic stroke (OR 1."1.51Oral short-acting antihypertensive medications and the occurrence of stroke: a nationwide case-crossover study. ( Chen, PC; Hsu, CY; Huang, LY; Lee, JD; Lee, M; Ovbiagele, B; Saver, JL; Wu, YL, 2019)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's10 (45.45)29.6817
2010's10 (45.45)24.3611
2020's2 (9.09)2.80

Authors

AuthorsStudies
Carrera, JF1
Sorace, BJ1
Worrall, BB1
Southerland, AM1
Chiota-McCollum, NA1
El-Ghoroury, H1
Sudekum, DM1
Hecht, JP2
Richards, PG1
Watson, K1
Broscious, R1
Devabhakthuni, S1
Noel, ZR1
Sharma, VK1
Tan, BYQ1
Sim, MY1
Kulkarni, A1
Seow, PA1
Hong, CS1
Du, Z1
Wong, LYH1
Chen, J1
Chee, EYH1
Ng, BSM1
Low, Y1
Ngiam, NJH1
Yeo, LLL1
Teoh, HL1
Paliwal, PR1
Rathakrishnan, R1
Sinha, AK1
Chan, BPL1
Butcher, K1
Anderson, CS1
Sadeghi, M1
Saber, H1
Singh, A1
Hanni, C1
Parker, D3
Desai, A1
Mohamed, W1
Hsu, CY1
Huang, LY1
Saver, JL1
Wu, YL1
Lee, JD1
Chen, PC1
Lee, M1
Ovbiagele, B1
Patel, V1
Ramachandran, B1
Omar, I1
Mashour, GA1
Sharifpour, M1
Freundlich, RE1
Tremper, KK1
Shanks, A1
Nallamothu, BK1
Vlisides, PE1
Weightman, A1
Matlen, L1
Merte, J1
Kheterpal, S1
Liu-DeRyke, X2
Levy, PD1
Coplin, W1
Rhoney, DH2
McKay, C1
Hall, AB1
Cortes, J1
Martin-Schild, S1
Potter, JF1
Robinson, TG1
Ford, GA1
Mistri, A2
James, M2
Chernova, J2
Jagger, C2
Potter, J1
Brodie, F1
Wilson, E1
Ford, G1
Robinson, T1
Woloszyn, AV1
McAllen, KJ1
Figueroa, BE1
DeShane, RS1
Barletta, JF1
Lindsberg, PJ1
Soinne, L1
Roine, RO1
Salonen, O1
Tatlisumak, T1
Kallela, M1
Häppölä, O1
Tiainen, M1
Haapaniemi, E1
Kuisma, M1
Kaste, M1
Harrington, C1
Ziliene, V1
Semplicini, A1
Calò, L1
Frishman, WH1
Veresh, M1
Schlocker, SJ1
Tejani, N1
Janisse, J1
Coplin, WM1
Norris, G1
Fischberg, GM1
Lozano, E1
Rajamani, K1
Ameriso, S1
Fisher, MJ1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomised Clinical Trial for Evaluating the Safety and Feasibility of Intensive Lowering of Blood Pressure in Acute Ischemic Stroke Patients Treated With Intravenous Thrombolysis[NCT03443596]Phase 2/Phase 354 participants (Actual)Interventional2014-12-01Completed
A Multi-center Randomised Controlled Trial to Explore the Ideal Individualized Anti-hypertension Strategies in Patients With Severe Stroke at Acute Stage[NCT02982655]500 participants (Anticipated)Interventional2017-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for labetalol and Apoplexy

ArticleYear
Focused Update on Pharmacologic Management of Hypertensive Emergencies.
    Current hypertension reports, 2018, 06-08, Volume: 20, Issue:7

    Topics: Administration, Oral; Antihypertensive Agents; Blood Pressure; Brain Ischemia; Emergencies; Enalapri

2018
Managing hypertension in patients with stroke. Are you prepared for labetalol infusion?
    Critical care nurse, 2003, Volume: 23, Issue:3

    Topics: Aged; Antihypertensive Agents; Cerebrovascular Circulation; Contraindications; Critical Care; Dose-R

2003
[Antihypertensive management in acute cerebral stroke].
    Medicina (Kaunas, Lithuania), 2005, Volume: 41, Issue:1

    Topics: Acute Disease; Adult; Antihypertensive Agents; Brain Injuries; Cerebrovascular Circulation; Emergenc

2005
Pathophysiology and medical management of systemic hypertension in preeclampsia.
    Current hypertension reports, 2006, Volume: 8, Issue:6

    Topics: Adrenergic beta-Antagonists; Aspirin; Calcium; Calcium Channel Blockers; Cerebral Hemorrhage; Female

2006

Trials

5 trials available for labetalol and Apoplexy

ArticleYear
Rationale and design of a randomized trial of early intensive blood pressure lowering on cerebral perfusion parameters in thrombolysed acute ischemic stroke patients.
    Medicine, 2018, Volume: 97, Issue:40

    Topics: Administration, Intravenous; Adult; Antihypertensive Agents; Blood Pressure; Brain Ischemia; Cerebro

2018
A prospective evaluation of labetalol versus nicardipine for blood pressure management in patients with acute stroke.
    Neurocritical care, 2013, Volume: 19, Issue:1

    Topics: Aged; Antihypertensive Agents; APACHE; Blood Pressure; Female; Hospital Mortality; Humans; Hypertens

2013
Controlling hypertension and hypotension immediately post-stroke (CHHIPS): a randomised, placebo-controlled, double-blind pilot trial.
    The Lancet. Neurology, 2009, Volume: 8, Issue:1

    Topics: Acute Disease; Aged; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Female; Humans; H

2009
Controlling hypertension and hypotension immediately post stroke (CHHIPS)--a randomised controlled trial.
    Health technology assessment (Winchester, England), 2009, Volume: 13, Issue:9

    Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Cardiotonic Agents; Cost-Benefit Analysis; Deg

2009
Community-based thrombolytic therapy of acute ischemic stroke in Helsinki.
    Stroke, 2003, Volume: 34, Issue:6

    Topics: Academic Medical Centers; Acute Disease; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Bl

2003

Other Studies

13 other studies available for labetalol and Apoplexy

ArticleYear
Delay to Tissue Plasminogen Activator in Hypertensive Stroke Patients: An Analysis of Delay Duration Across Agents.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2020, Volume: 29, Issue:2

    Topics: Aged; Antihypertensive Agents; Blood Pressure; Drug Administration Schedule; Female; Fibrinolytic Ag

2020
Blood Pressure Control in Acute Stroke: Labetalol or Nicardipine?
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2021, Volume: 30, Issue:9

    Topics: Adrenergic alpha-1 Receptor Antagonists; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pre

2021
Continuous-Infusion Labetalol vs Nicardipine for Hypertension Management in Stroke Patients.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2018, Volume: 27, Issue:2

    Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Calci

2018
Nicardipine Associated Risk of Short-Term Mortality in Critically Ill Patients with Ischemic Stroke.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2019, Volume: 28, Issue:5

    Topics: Aged; Antihypertensive Agents; Blood Pressure; Brain Ischemia; Critical Illness; Databases, Factual;

2019
Oral short-acting antihypertensive medications and the occurrence of stroke: a nationwide case-crossover study.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2019, Volume: 42, Issue:11

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Captopril; Cerebral Hemorrhage; Female; Humans; La

2019
Posterior reversible encephalopathy syndrome, preeclampsia or stroke? A diagnostic dilemma.
    BMJ case reports, 2019, Jul-27, Volume: 12, Issue:7

    Topics: Abdominal Pain; Adrenergic beta-Antagonists; Aspirin; Diagnosis, Differential; Factor V; Female; Hea

2019
Perioperative metoprolol and risk of stroke after noncardiac surgery.
    Anesthesiology, 2013, Volume: 119, Issue:6

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Analysis of Variance; Ateno

2013
Time to Blood Pressure Control Before Thrombolytic Therapy in Patients With Acute Ischemic Stroke: Comparison of Labetalol, Nicardipine, and Hydralazine.
    The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses, 2015, Volume: 47, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Brain Ischemia; Female; Fib

2015
Blood pressure in acute stroke: lower it or let the CHHIPS fall where they will.
    The Lancet. Neurology, 2009, Volume: 8, Issue:1

    Topics: Acute Disease; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Humans; Hypertensi

2009
Retrospective evaluation of nicardipine versus labetalol for blood pressure control in aneurysmal subarachnoid hemorrhage.
    Neurocritical care, 2012, Volume: 16, Issue:3

    Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Critical Care; Female; Humans; Hypertension; L

2012
Administering antihypertensive drugs after acute ischemic stroke: timing is everything.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2005, Mar-01, Volume: 172, Issue:5

    Topics: Acute Disease; Antihypertensive Agents; Brain; Brain Ischemia; Cerebrovascular Circulation; Homeosta

2005
A comparison of nicardipine and labetalol for acute hypertension management following stroke.
    Neurocritical care, 2008, Volume: 9, Issue:2

    Topics: Acute Disease; Aged; Antihypertensive Agents; APACHE; Blood Pressure; Brain Ischemia; Cerebral Hemor

2008
Stroke precipitated by moderate blood pressure reduction.
    The Journal of emergency medicine, 2000, Volume: 19, Issue:4

    Topics: Adult; Antihypertensive Agents; Blood Pressure; Emergency Treatment; Felodipine; Female; Humans; Hyp

2000