labetalol has been researched along with Apoplexy in 22 studies
Labetalol: A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.
labetalol : A diastereoisomeric mixture of approximately equal amounts of all four possible stereoisomers ((R,S)-labetolol, (S,R)-labetolol, (S,S)-labetalol and (R,R)-labetalol). It is an adrenergic antagonist used to treat high blood pressure.
2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide : A member of the class of benzamides that is benzamide substituted by a hydroxy group at position 2 and by a 1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This is a prospective, pseudo-randomized study comparing labetalol and nicardipine for blood pressure (BP) management in acute stroke patients." | 9.17 | A prospective evaluation of labetalol versus nicardipine for blood pressure management in patients with acute stroke. ( Coplin, W; Levy, PD; Liu-DeRyke, X; Parker, D; Rhoney, DH, 2013) |
| " Critical care nurses who appreciate the considerations for treatment of hypertension and who can correctly and efficiently administer intravenous labetalol may save precious time and enhance outcomes for patients with stroke who have hypertension." | 8.82 | Managing hypertension in patients with stroke. Are you prepared for labetalol infusion? ( Harrington, C, 2003) |
| "To assess the safety and efficacy of continuous infusion (CIV)-labetalol compared to -nicardipine in controlling blood pressure (BP) in the acute stroke setting." | 8.02 | Blood Pressure Control in Acute Stroke: Labetalol or Nicardipine? ( El-Ghoroury, H; Hecht, JP; Sudekum, DM, 2021) |
| " Nicardipine and labetalol are commonly administered for the treatment of acute hypertension following stroke." | 7.91 | Nicardipine Associated Risk of Short-Term Mortality in Critically Ill Patients with Ischemic Stroke. ( Desai, A; Hanni, C; Mohamed, W; Parker, D; Saber, H; Sadeghi, M; Singh, A, 2019) |
| "Labetalol and nicardipine are antihypertensives commonly used in the management of elevated blood pressure (BP) following an acute stroke, but there is limited evidence to suggest which agent as a continuous infusion should be used preferentially in this setting." | 7.88 | Continuous-Infusion Labetalol vs Nicardipine for Hypertension Management in Stroke Patients. ( Hecht, JP; Richards, PG, 2018) |
| "This study aimed to compare the effects of labetalol, nicardipine, or hydralazine on time to target blood pressure before alteplase administration in patients with acute ischemic stroke." | 7.81 | Time to Blood Pressure Control Before Thrombolytic Therapy in Patients With Acute Ischemic Stroke: Comparison of Labetalol, Nicardipine, and Hydralazine. ( Cortes, J; Hall, AB; McKay, C, 2015) |
| "Routine use of preoperative metoprolol, but not atenolol, is associated with stroke after noncardiac surgery, even after adjusting for comorbidities." | 7.79 | Perioperative metoprolol and risk of stroke after noncardiac surgery. ( Freundlich, RE; Kheterpal, S; Mashour, GA; Matlen, L; Merte, J; Nallamothu, BK; Shanks, A; Sharifpour, M; Tremper, KK; Vlisides, PE; Weightman, A, 2013) |
| "American Heart Association/American Stroke Association guidelines for management of aneurysmal subarachnoid hemorrhage (aSAH) recommend blood pressure (BP) control, utilizing labetalol or nicardipine, but do not differentiate efficacy between the two agents." | 7.78 | Retrospective evaluation of nicardipine versus labetalol for blood pressure control in aneurysmal subarachnoid hemorrhage. ( Barletta, JF; DeShane, RS; Figueroa, BE; McAllen, KJ; Woloszyn, AV, 2012) |
| "Evaluate the ease of use and tolerability of labetalol (L) and nicardipine (N) for hypertension management in patients with acute stroke." | 7.74 | A comparison of nicardipine and labetalol for acute hypertension management following stroke. ( Coplin, WM; Janisse, J; Liu-Deryke, X; Norris, G; Parker, D; Rhoney, DH, 2008) |
| "This is a prospective, pseudo-randomized study comparing labetalol and nicardipine for blood pressure (BP) management in acute stroke patients." | 5.17 | A prospective evaluation of labetalol versus nicardipine for blood pressure management in patients with acute stroke. ( Coplin, W; Levy, PD; Liu-DeRyke, X; Parker, D; Rhoney, DH, 2013) |
| "Labetalol and lisinopril are effective antihypertensive drugs in acute stroke that do not increase serious adverse events." | 5.14 | Controlling hypertension and hypotension immediately post-stroke (CHHIPS): a randomised, placebo-controlled, double-blind pilot trial. ( Chernova, J; Ford, GA; Jagger, C; James, M; Mistri, A; Potter, JF; Robinson, TG, 2009) |
| " Oral nifedipine is now considered an alternative first-line therapy, along with intravenous hydralazine and labetalol for women presenting with pre-eclampsia." | 4.98 | Focused Update on Pharmacologic Management of Hypertensive Emergencies. ( Broscious, R; Devabhakthuni, S; Noel, ZR; Watson, K, 2018) |
| " Critical care nurses who appreciate the considerations for treatment of hypertension and who can correctly and efficiently administer intravenous labetalol may save precious time and enhance outcomes for patients with stroke who have hypertension." | 4.82 | Managing hypertension in patients with stroke. Are you prepared for labetalol infusion? ( Harrington, C, 2003) |
| "To assess the safety and efficacy of continuous infusion (CIV)-labetalol compared to -nicardipine in controlling blood pressure (BP) in the acute stroke setting." | 4.02 | Blood Pressure Control in Acute Stroke: Labetalol or Nicardipine? ( El-Ghoroury, H; Hecht, JP; Sudekum, DM, 2021) |
| " Nicardipine and labetalol are commonly administered for the treatment of acute hypertension following stroke." | 3.91 | Nicardipine Associated Risk of Short-Term Mortality in Critically Ill Patients with Ischemic Stroke. ( Desai, A; Hanni, C; Mohamed, W; Parker, D; Saber, H; Sadeghi, M; Singh, A, 2019) |
| "Labetalol and nicardipine are antihypertensives commonly used in the management of elevated blood pressure (BP) following an acute stroke, but there is limited evidence to suggest which agent as a continuous infusion should be used preferentially in this setting." | 3.88 | Continuous-Infusion Labetalol vs Nicardipine for Hypertension Management in Stroke Patients. ( Hecht, JP; Richards, PG, 2018) |
| "This study aimed to compare the effects of labetalol, nicardipine, or hydralazine on time to target blood pressure before alteplase administration in patients with acute ischemic stroke." | 3.81 | Time to Blood Pressure Control Before Thrombolytic Therapy in Patients With Acute Ischemic Stroke: Comparison of Labetalol, Nicardipine, and Hydralazine. ( Cortes, J; Hall, AB; McKay, C, 2015) |
| "Routine use of preoperative metoprolol, but not atenolol, is associated with stroke after noncardiac surgery, even after adjusting for comorbidities." | 3.79 | Perioperative metoprolol and risk of stroke after noncardiac surgery. ( Freundlich, RE; Kheterpal, S; Mashour, GA; Matlen, L; Merte, J; Nallamothu, BK; Shanks, A; Sharifpour, M; Tremper, KK; Vlisides, PE; Weightman, A, 2013) |
| "American Heart Association/American Stroke Association guidelines for management of aneurysmal subarachnoid hemorrhage (aSAH) recommend blood pressure (BP) control, utilizing labetalol or nicardipine, but do not differentiate efficacy between the two agents." | 3.78 | Retrospective evaluation of nicardipine versus labetalol for blood pressure control in aneurysmal subarachnoid hemorrhage. ( Barletta, JF; DeShane, RS; Figueroa, BE; McAllen, KJ; Woloszyn, AV, 2012) |
| "Evaluate the ease of use and tolerability of labetalol (L) and nicardipine (N) for hypertension management in patients with acute stroke." | 3.74 | A comparison of nicardipine and labetalol for acute hypertension management following stroke. ( Coplin, WM; Janisse, J; Liu-Deryke, X; Norris, G; Parker, D; Rhoney, DH, 2008) |
| "In the case of hypertensive encephalopathy, the lowering of blood pressure is therapeutic as well as diagnostic." | 2.43 | [Antihypertensive management in acute cerebral stroke]. ( Ziliene, V, 2005) |
| "Hypertension that complicates preeclampsia in pregnancy is a disorder that requires special consideration in both prevention and pharmacologic treatment." | 2.43 | Pathophysiology and medical management of systemic hypertension in preeclampsia. ( Frishman, WH; Schlocker, SJ; Tejani, N; Veresh, M, 2006) |
| " The long-term use of short-acting nifedipine for 30 days was associated with a modest increase in the risk for ischemic stroke (OR 1." | 1.51 | Oral short-acting antihypertensive medications and the occurrence of stroke: a nationwide case-crossover study. ( Chen, PC; Hsu, CY; Huang, LY; Lee, JD; Lee, M; Ovbiagele, B; Saver, JL; Wu, YL, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (45.45) | 29.6817 |
| 2010's | 10 (45.45) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Carrera, JF | 1 |
| Sorace, BJ | 1 |
| Worrall, BB | 1 |
| Southerland, AM | 1 |
| Chiota-McCollum, NA | 1 |
| El-Ghoroury, H | 1 |
| Sudekum, DM | 1 |
| Hecht, JP | 2 |
| Richards, PG | 1 |
| Watson, K | 1 |
| Broscious, R | 1 |
| Devabhakthuni, S | 1 |
| Noel, ZR | 1 |
| Sharma, VK | 1 |
| Tan, BYQ | 1 |
| Sim, MY | 1 |
| Kulkarni, A | 1 |
| Seow, PA | 1 |
| Hong, CS | 1 |
| Du, Z | 1 |
| Wong, LYH | 1 |
| Chen, J | 1 |
| Chee, EYH | 1 |
| Ng, BSM | 1 |
| Low, Y | 1 |
| Ngiam, NJH | 1 |
| Yeo, LLL | 1 |
| Teoh, HL | 1 |
| Paliwal, PR | 1 |
| Rathakrishnan, R | 1 |
| Sinha, AK | 1 |
| Chan, BPL | 1 |
| Butcher, K | 1 |
| Anderson, CS | 1 |
| Sadeghi, M | 1 |
| Saber, H | 1 |
| Singh, A | 1 |
| Hanni, C | 1 |
| Parker, D | 3 |
| Desai, A | 1 |
| Mohamed, W | 1 |
| Hsu, CY | 1 |
| Huang, LY | 1 |
| Saver, JL | 1 |
| Wu, YL | 1 |
| Lee, JD | 1 |
| Chen, PC | 1 |
| Lee, M | 1 |
| Ovbiagele, B | 1 |
| Patel, V | 1 |
| Ramachandran, B | 1 |
| Omar, I | 1 |
| Mashour, GA | 1 |
| Sharifpour, M | 1 |
| Freundlich, RE | 1 |
| Tremper, KK | 1 |
| Shanks, A | 1 |
| Nallamothu, BK | 1 |
| Vlisides, PE | 1 |
| Weightman, A | 1 |
| Matlen, L | 1 |
| Merte, J | 1 |
| Kheterpal, S | 1 |
| Liu-DeRyke, X | 2 |
| Levy, PD | 1 |
| Coplin, W | 1 |
| Rhoney, DH | 2 |
| McKay, C | 1 |
| Hall, AB | 1 |
| Cortes, J | 1 |
| Martin-Schild, S | 1 |
| Potter, JF | 1 |
| Robinson, TG | 1 |
| Ford, GA | 1 |
| Mistri, A | 2 |
| James, M | 2 |
| Chernova, J | 2 |
| Jagger, C | 2 |
| Potter, J | 1 |
| Brodie, F | 1 |
| Wilson, E | 1 |
| Ford, G | 1 |
| Robinson, T | 1 |
| Woloszyn, AV | 1 |
| McAllen, KJ | 1 |
| Figueroa, BE | 1 |
| DeShane, RS | 1 |
| Barletta, JF | 1 |
| Lindsberg, PJ | 1 |
| Soinne, L | 1 |
| Roine, RO | 1 |
| Salonen, O | 1 |
| Tatlisumak, T | 1 |
| Kallela, M | 1 |
| Häppölä, O | 1 |
| Tiainen, M | 1 |
| Haapaniemi, E | 1 |
| Kuisma, M | 1 |
| Kaste, M | 1 |
| Harrington, C | 1 |
| Ziliene, V | 1 |
| Semplicini, A | 1 |
| Calò, L | 1 |
| Frishman, WH | 1 |
| Veresh, M | 1 |
| Schlocker, SJ | 1 |
| Tejani, N | 1 |
| Janisse, J | 1 |
| Coplin, WM | 1 |
| Norris, G | 1 |
| Fischberg, GM | 1 |
| Lozano, E | 1 |
| Rajamani, K | 1 |
| Ameriso, S | 1 |
| Fisher, MJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised Clinical Trial for Evaluating the Safety and Feasibility of Intensive Lowering of Blood Pressure in Acute Ischemic Stroke Patients Treated With Intravenous Thrombolysis[NCT03443596] | Phase 2/Phase 3 | 54 participants (Actual) | Interventional | 2014-12-01 | Completed | ||
| A Multi-center Randomised Controlled Trial to Explore the Ideal Individualized Anti-hypertension Strategies in Patients With Severe Stroke at Acute Stage[NCT02982655] | 500 participants (Anticipated) | Interventional | 2017-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for labetalol and Apoplexy
| Article | Year |
|---|---|
Focused Update on Pharmacologic Management of Hypertensive Emergencies.
Topics: Administration, Oral; Antihypertensive Agents; Blood Pressure; Brain Ischemia; Emergencies; Enalapri | 2018 |
Managing hypertension in patients with stroke. Are you prepared for labetalol infusion?
Topics: Aged; Antihypertensive Agents; Cerebrovascular Circulation; Contraindications; Critical Care; Dose-R | 2003 |
[Antihypertensive management in acute cerebral stroke].
Topics: Acute Disease; Adult; Antihypertensive Agents; Brain Injuries; Cerebrovascular Circulation; Emergenc | 2005 |
Pathophysiology and medical management of systemic hypertension in preeclampsia.
Topics: Adrenergic beta-Antagonists; Aspirin; Calcium; Calcium Channel Blockers; Cerebral Hemorrhage; Female | 2006 |
5 trials available for labetalol and Apoplexy
| Article | Year |
|---|---|
Rationale and design of a randomized trial of early intensive blood pressure lowering on cerebral perfusion parameters in thrombolysed acute ischemic stroke patients.
Topics: Administration, Intravenous; Adult; Antihypertensive Agents; Blood Pressure; Brain Ischemia; Cerebro | 2018 |
A prospective evaluation of labetalol versus nicardipine for blood pressure management in patients with acute stroke.
Topics: Aged; Antihypertensive Agents; APACHE; Blood Pressure; Female; Hospital Mortality; Humans; Hypertens | 2013 |
Controlling hypertension and hypotension immediately post-stroke (CHHIPS): a randomised, placebo-controlled, double-blind pilot trial.
Topics: Acute Disease; Aged; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Female; Humans; H | 2009 |
Controlling hypertension and hypotension immediately post stroke (CHHIPS)--a randomised controlled trial.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Cardiotonic Agents; Cost-Benefit Analysis; Deg | 2009 |
Community-based thrombolytic therapy of acute ischemic stroke in Helsinki.
Topics: Academic Medical Centers; Acute Disease; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Bl | 2003 |
13 other studies available for labetalol and Apoplexy
| Article | Year |
|---|---|
Delay to Tissue Plasminogen Activator in Hypertensive Stroke Patients: An Analysis of Delay Duration Across Agents.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Drug Administration Schedule; Female; Fibrinolytic Ag | 2020 |
Blood Pressure Control in Acute Stroke: Labetalol or Nicardipine?
Topics: Adrenergic alpha-1 Receptor Antagonists; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pre | 2021 |
Continuous-Infusion Labetalol vs Nicardipine for Hypertension Management in Stroke Patients.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Calci | 2018 |
Nicardipine Associated Risk of Short-Term Mortality in Critically Ill Patients with Ischemic Stroke.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Brain Ischemia; Critical Illness; Databases, Factual; | 2019 |
Oral short-acting antihypertensive medications and the occurrence of stroke: a nationwide case-crossover study.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Captopril; Cerebral Hemorrhage; Female; Humans; La | 2019 |
Posterior reversible encephalopathy syndrome, preeclampsia or stroke? A diagnostic dilemma.
Topics: Abdominal Pain; Adrenergic beta-Antagonists; Aspirin; Diagnosis, Differential; Factor V; Female; Hea | 2019 |
Perioperative metoprolol and risk of stroke after noncardiac surgery.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Analysis of Variance; Ateno | 2013 |
Time to Blood Pressure Control Before Thrombolytic Therapy in Patients With Acute Ischemic Stroke: Comparison of Labetalol, Nicardipine, and Hydralazine.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Brain Ischemia; Female; Fib | 2015 |
Blood pressure in acute stroke: lower it or let the CHHIPS fall where they will.
Topics: Acute Disease; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Humans; Hypertensi | 2009 |
Retrospective evaluation of nicardipine versus labetalol for blood pressure control in aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Critical Care; Female; Humans; Hypertension; L | 2012 |
Administering antihypertensive drugs after acute ischemic stroke: timing is everything.
Topics: Acute Disease; Antihypertensive Agents; Brain; Brain Ischemia; Cerebrovascular Circulation; Homeosta | 2005 |
A comparison of nicardipine and labetalol for acute hypertension management following stroke.
Topics: Acute Disease; Aged; Antihypertensive Agents; APACHE; Blood Pressure; Brain Ischemia; Cerebral Hemor | 2008 |
Stroke precipitated by moderate blood pressure reduction.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Emergency Treatment; Felodipine; Female; Humans; Hyp | 2000 |