labdane and Dengue

labdane has been researched along with Dengue* in 1 studies

Other Studies

1 other study(ies) available for labdane and Dengue

Article	Year
Stachyonic Acid: A Dengue Virus Inhibitor from Basilicum polystachyon. Chemistry (Weinheim an der Bergstrasse, Germany), 2019, Apr-17, Volume: 25, Issue:22 Stachyonic acid A, arising from the first in-depth phytochemical investigation of the herb Basilicum polystachyon, was found to display potent inhibitory activity against dengue virus, with limited cytotoxicity. Andrographolide, a known dengue virus inhibitor and closely related labdane-type diterpene, is structurally more complex but displayed poor antiviral activity in the PRNT assay, and increased cytotoxicity in comparison. Furthermore, a Diels-Alder reaction with PTAD identified the active pharmacophore of stachyonic acid to be the conjugated diene. Topics: Antiviral Agents; Dengue; Dengue Virus; Diterpenes; Drug Discovery; Humans; Lamiaceae; Models, Molecular; Virus Replication	2019

Article

Year

Stachyonic Acid: A Dengue Virus Inhibitor from Basilicum polystachyon.

Chemistry (Weinheim an der Bergstrasse, Germany), 2019, Apr-17, Volume: 25, Issue:22

Stachyonic acid A, arising from the first in-depth phytochemical investigation of the herb Basilicum polystachyon, was found to display potent inhibitory activity against dengue virus, with limited cytotoxicity. Andrographolide, a known dengue virus inhibitor and closely related labdane-type diterpene, is structurally more complex but displayed poor antiviral activity in the PRNT assay, and increased cytotoxicity in comparison. Furthermore, a Diels-Alder reaction with PTAD identified the active pharmacophore of stachyonic acid to be the conjugated diene.

Topics: Antiviral Agents; Dengue; Dengue Virus; Diterpenes; Drug Discovery; Humans; Lamiaceae; Models, Molecular; Virus Replication

2019