labdane has been researched along with Dengue* in 1 studies
1 other study(ies) available for labdane and Dengue
Article | Year |
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Stachyonic Acid: A Dengue Virus Inhibitor from Basilicum polystachyon.
Stachyonic acid A, arising from the first in-depth phytochemical investigation of the herb Basilicum polystachyon, was found to display potent inhibitory activity against dengue virus, with limited cytotoxicity. Andrographolide, a known dengue virus inhibitor and closely related labdane-type diterpene, is structurally more complex but displayed poor antiviral activity in the PRNT assay, and increased cytotoxicity in comparison. Furthermore, a Diels-Alder reaction with PTAD identified the active pharmacophore of stachyonic acid to be the conjugated diene. Topics: Antiviral Agents; Dengue; Dengue Virus; Diterpenes; Drug Discovery; Humans; Lamiaceae; Models, Molecular; Virus Replication | 2019 |