la-419 and Hypertension--Pulmonary

la-419 has been researched along with Hypertension--Pulmonary* in 1 studies

Other Studies

1 other study(ies) available for la-419 and Hypertension--Pulmonary

ArticleYear
Treatment with LA-419 prevents monocrotaline-induced pulmonary hypertension and lung injury in the rat.
    Proceedings of the Western Pharmacology Society, 2011, Volume: 54

    We evaluated the therapeutic potential of LA-419, a hybrid organic nitrate that donates nitric oxide and thiol groups, to improve pulmonary arterial hypertension in an experimental model induced by monocrotaline in the rat. Treatment with LA-419 from the first day after monocrotaline administration prevented the increase in pulmonary pressure as well as the increases in ventricle/body weight and pulmonary artery wall thickness. Administration of LA-419 after establishment of hypertensive status also resulted in an improvement of these parameters. Both preventive and therapeutic treatments reduced mortality. The antioxidant effect of LA-419 was comparable to that achieved with a-tocopherol. Pulmonary remodeling accomplished by LA-419 could be attributed to a balanced antioxidant effect associated with its nitric oxide/SH donor capability. Thus, LA-419 might represent a new therapeutic approach in severe pulmonary hypertension in humans.

    Topics: Animals; Blood Pressure; Hypertension, Pulmonary; Isosorbide Dinitrate; Male; Monocrotaline; Nitric Oxide Donors; Rats; Rats, Wistar

2011