l-838-417 and Neuralgia

l-838-417 has been researched along with Neuralgia* in 1 studies

Other Studies

1 other study(ies) available for l-838-417 and Neuralgia

Article	Year
Enhancing neuronal chloride extrusion rescues α2/α3 GABA Nature communications, 2020, 02-13, Volume: 11, Issue:1 Spinal disinhibition has been hypothesized to underlie pain hypersensitivity in neuropathic pain. Apparently contradictory mechanisms have been reported, raising questions on the best target to produce analgesia. Here, we show that nerve injury is associated with a reduction in the number of inhibitory synapses in the spinal dorsal horn. Paradoxically, this is accompanied by a BDNF-TrkB-mediated upregulation of synaptic GABA Topics: Analgesia; Analgesics; Animals; Brain-Derived Neurotrophic Factor; Chlorides; Disease Models, Animal; Fluorobenzenes; GABA-A Receptor Agonists; Ion Transport; K Cl- Cotransporters; Ligands; Male; Neuralgia; Neurons; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, GABA-A; Symporters; Synapses; Triazoles	2020

Article

Year

Enhancing neuronal chloride extrusion rescues α2/α3 GABA

Nature communications, 2020, 02-13, Volume: 11, Issue:1

Spinal disinhibition has been hypothesized to underlie pain hypersensitivity in neuropathic pain. Apparently contradictory mechanisms have been reported, raising questions on the best target to produce analgesia. Here, we show that nerve injury is associated with a reduction in the number of inhibitory synapses in the spinal dorsal horn. Paradoxically, this is accompanied by a BDNF-TrkB-mediated upregulation of synaptic GABA

Topics: Analgesia; Analgesics; Animals; Brain-Derived Neurotrophic Factor; Chlorides; Disease Models, Animal; Fluorobenzenes; GABA-A Receptor Agonists; Ion Transport; K Cl- Cotransporters; Ligands; Male; Neuralgia; Neurons; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, GABA-A; Symporters; Synapses; Triazoles

2020