l-796449 has been researched along with Obesity* in 2 studies
1 review(s) available for l-796449 and Obesity
| Article | Year |
|---|---|
The PPARs: from orphan receptors to drug discovery.
Topics: Animals; Diabetes Mellitus; Drug Design; Humans; Hyperlipidemias; Hypertension; Inflammation; Ligands; Models, Molecular; Neoplasms; Nuclear Proteins; Obesity; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2000 |
1 other study(ies) available for l-796449 and Obesity
| Article | Year |
|---|---|
Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated receptor δ agonists as potent anti-obesity agents in vivo.
We have discovered and demonstrated the in vitro and in vivo PPARδ-selective activity of novel Y-shaped agonists. These compounds activated hPPARδ with EC(50) values between 1 and 523 nM. Surprisingly, compounds 10a, 11d, 11e and 11f were the most potent and most selective hPPARδ agonists with 10(4)-fold selectivity over the other two subtypes, namely, hPPARα and hPPARγ. The PPARδ ligands 10a, 11e and 11f showed good bioavailability and in vivo efficacy. Topics: Animals; Anti-Obesity Agents; Chemistry Techniques, Synthetic; Diet, High-Fat; Dose-Response Relationship, Drug; Drug Design; Humans; Mice; Models, Molecular; Obesity; PPAR delta; Protein Conformation | 2012 |