l-764646 and Tachycardia

l-764646 has been researched along with Tachycardia* in 1 studies

Other Studies

1 other study(ies) available for l-764646 and Tachycardia

Article	Year
Human beta3-adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides. Bioorganic & medicinal chemistry letters, 2000, Sep-18, Volume: 10, Issue:18 Compounds containing a 1,2,3-triazole-substituted benzenesulfonamide were prepared and found to be potent and selective human beta3-adrenergic receptor agonists. The most interesting compound, trifluoromethylbenzyl analogue 12e (beta3 EC50 = 3.1 nM with >1500-fold selectivity over binding to both beta1- and beta2 receptors), stimulates lipolysis in the rhesus monkey (ED50 = 0.36 mg/kg) and is 25% orally bioavailable in the dog. Topics: Administration, Oral; Adrenergic beta-3 Receptor Agonists; Animals; Benzenesulfonamides; Biological Availability; CHO Cells; Cricetinae; Cyclic AMP; Dogs; Dose-Response Relationship, Drug; Humans; Infusions, Parenteral; Isoproterenol; Lipolysis; Macaca mulatta; Protein Binding; Receptors, Adrenergic, beta-3; Structure-Activity Relationship; Sulfonamides; Tachycardia; Triazoles	2000

Article

Year

Human beta3-adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides.

Bioorganic & medicinal chemistry letters, 2000, Sep-18, Volume: 10, Issue:18

Compounds containing a 1,2,3-triazole-substituted benzenesulfonamide were prepared and found to be potent and selective human beta3-adrenergic receptor agonists. The most interesting compound, trifluoromethylbenzyl analogue 12e (beta3 EC50 = 3.1 nM with >1500-fold selectivity over binding to both beta1- and beta2 receptors), stimulates lipolysis in the rhesus monkey (ED50 = 0.36 mg/kg) and is 25% orally bioavailable in the dog.

Topics: Administration, Oral; Adrenergic beta-3 Receptor Agonists; Animals; Benzenesulfonamides; Biological Availability; CHO Cells; Cricetinae; Cyclic AMP; Dogs; Dose-Response Relationship, Drug; Humans; Infusions, Parenteral; Isoproterenol; Lipolysis; Macaca mulatta; Protein Binding; Receptors, Adrenergic, beta-3; Structure-Activity Relationship; Sulfonamides; Tachycardia; Triazoles

2000